Use of naturally glycosylated polyphenols as protective agents against the effects of ultraviolet irradiation

Abstract

Use of a naturally glycosylated polyphenol, not containing nitrogen, as protective agent against the effects of ultraviolet irradiation on photo-degradable substances of structures.

Claims

1. A method for protecting human skin from UV irradiation comprising applying a composition to the skin, wherein: the composition comprises a naturally glycosylated polyphenol not containing nitrogen selected from the group consisting of verbascoside, teupolioside, baicalein, silibin and leontopodic acid; the naturally glycosylated polyphenol is present in the composition at a concentration of at least 20 μM; the composition further comprises water which contains at least 500 ppm of .sup.18O and at most 1100 ppm of .sup.18O, and at least 20 ppm of .sup.2H and at most 90 ppm of .sup.2H.

2. The method according to claim 1, wherein the naturally glycosylated polyphenol is obtained from extracts of terrestrial plants, sea plants, sea organisms or plant cell cultures.

3. The method according to claim 1, wherein the composition comprises a mixture of two or more selected from the group.

4. The method according to claim 1, wherein a sugar moiety of the glycosylated polyphenol is rhamnose, arabinose or mannose.

5. The method according to claim 1, wherein the composition ameliorates natural photo-protection-related antioxidant properties of the skin.

6. The method according to claim 1, wherein the composition is a sun-protective composition.

7. The method according to claim 1, wherein the composition is a topical cosmetic composition in a form of a gel, spray, cream or lotion.

8. The method according to claim 1, wherein the composition further comprises one or more topically applied corticosteroids, non-steroidal anti-inflammatory drugs, antibiotics or anti-viral agents.

9. The method according to claim 1, wherein the composition protects skin against redness, swelling, pain or premature ageing of the skin.

10. The method according to claim 1, wherein the composition further comprises TiO.sub.2 and/or ZnO.

11. A composition for topical application to human skin for treatment or prophylaxis against aging of the skin caused by exposure to oxidation, the composition comprising an effective amount of a naturally glycosylated polyphenol not containing nitrogen selected from the group consisting of verbascoside, teupolioside, baicalein, silibin and leontopodic acid, wherein the naturally glycosylated polyphenol is present in the composition at a concentration of at least 20 μM, and wherein the composition further comprises water which contains at least 500 ppm of .sup.18O and at most 1100 ppm of .sup.18O and at least 20 ppm of .sup.2H and at most 90 ppm of .sup.2H.

12. The composition according to claim 11, wherein the naturally glycosylated polyphenol is present in the composition at a concentration of at most 500 μM.

13. The composition according to claim 11, wherein the naturally glycosylated polyphenol is present in the composition at a concentration of at most 80 μM.

14. The composition according to claim 11, wherein the composition further comprises TiO.sub.2 and/or ZnO.

15. The composition according to claim 11, wherein the composition further comprises one or more topically applied corticosteroids, non-steroidal anti-inflammatory drugs, antibiotics or anti-viral agents.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) The following examples clarify the invention further in more detail.

Example 1: Broad-Band Sun Protection Gel (SPF-B >50 and UV-A/UV-B Ratio >1)

(2) TABLE-US-00003 COMPONENT Weigth % AQUA 58.02 BAICALEIN (glycosylated flavonoid) 8.00 TAXIFOLIN (glycosylated flavonoid) 7.00 EXTRACT OF SCUTELLARIA BAICALENSIS (content of 6.00 glycosylated polyphenols >80%) EXTRACT OF MILK THISTLE SEEDS (content of 5.00 glycosylated polyphenols >90%) Excipients to provide product viscosity and fluidity 15.03 (e.g glycerin, cetylpyridinium chloride) Salts and buffers for pH control (f.e. sodium chloride, 0.95 sodium hydroxide, and potassium chloride)

Example 2: Broad-Band Sun Protection Light Cream (in Particular for Pregnant Women): SPF-B >50 and the UV-A/UV-B Ratio >0.5<1)

(3) TABLE-US-00004 COMPONENT Weight % AQUA 48.3597156 EXTRACT OF ROSMARINUS OFFICINALIS (content of glycosylated 6.0000000 polyphenols >90%) LEONTOPODIC ACIDS (glycosylated polyphenols) 5.2000000 EXTRACT OF LEONTOPODIUM ALPINUM MERISTEM CELLS 5.0000000 (content of glycosylated polyphenols >90%) EXTRACT OF SYRINGA VULGARIS MERISTEM CELLS (content of 4.5000000 glycosylated polyphenols >75%) Excipients for skin nutrition (e.g. fatty acids, long chain alcohols, 26.1694016 lipids, glycerin and its derivatives) Excipients to maintain cream viscosity and fluidity (e.g, 1.9500000 microcrystalline cellulose, cyclopentasiloxane, cellulose gum, acrylates) Excipients to preserve product against oxidative and microbial 1.5918000 decomposition (e.g. phenoxyethanol, retinyl palmitate, ANOGEISSUS LEIOCARPUS BARK EXTRACT, tocopherol, COENOCHLORIS SIGNIENSIS EXTRACT Excipients for skin moisturising (e.g. sodium hyaluronate, sodium 0.8020000 stearoyl glutamate, dimethicone, maltodextrin, soluble collagen) Parfume 0.29992440 Salts and buffers for pH control (sodium chloride, benzoate, 0.1280000 phosphate, and hydroxide, potassium sorbate)

Example 3: Broad-Band Sun Protection Milk in Particular for Babies and Children) SPF-B >50 and the UV-A/UV-B Ratio >0.5<1.0

(4) TABLE-US-00005 COMPONENT WEIGHT % AQUA 58.4755157 VERBASCOSIDE (PHENYLPROPANOID DIGLYCOSIDE) 6.5000000 EXTRACT of VERBENA OFFICINALIS (CONTENT OF GLYCOSYLATED 6.0000000 POLYPHENOLS >95%) KAEMPFEROL MONOGLYCOSIDE 5.0000000 EXTRACT OF SAMBUCUS NIGRA (CONTENT OF GLYCOSYLATED 5.0000000 POLYPHENOLS >92%) Excipients to provide viscosity and fluidity (e.g. paraffin, dicapryryl 12.0875000 carbonate, sodium polyacrylate, xanthan gum, lauryl glucoside Excipients to provide solidity and smooth/even distribution on the 5.6030000 skin surface (e.g. butters, lecithin, glycerin and its derivatives) Excipients to preserve product from oxidation and microbial 1.0120000 degradation (e.g. phenoxyethanol, disodium EDTA, tocopherol and tocopheryl acetate, ascorbyl palmitate) Perfume 0.2999843 pH control (sodium hydroxide) 0.0220000

Example 4: Broad-Band Sun Protection Spray (30<SPF-B<50 and the UV-A/UV-B Ratio >1)

(5) TABLE-US-00006 COMPONENT WEIGHT % EXTRACT OF OSAGE ORANGE (content of glycosylated 5.0000000 polyphenols >90%) EXTRACT OF MILK THISTLE SEEDS (content of glycosylated 5.0000000 flavonoids >75%) MORIN (glycosylated flavonoid) 4.6000000 EXTRACT OF SOPHORA JAPONICA FLOWERS (content of 3.5000000 glycosylated flavonoid rutin >90%) Excipient - solvent (distilled water) 1.6070614 Excipients - Organic solvents and gases (e.g. isobutane, alcohol 79.9201130 denat., propane, butane) Excipients to provide viscosity (e.g. PVP, isosteareth-20, PEG-12 0.3045000 dimethicone) Excipients to prevent oxidative and microbial decomposition (e.g. 0.0381136 panthenol, limonene, linalool) Perfume 0.0302120

(6) Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the scope of the appended claims.

(7) It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination or as suitable in any other described embodiment of the invention. Certain features described in the context of various embodiments are not to be considered essential features of those embodiments, unless the embodiment is inoperative without those elements.