INSECT, ACARINA AND NEMATODE PEST CONTROL

Abstract

The present invention relates to combinations of a compound of formula (I), wherein: R.sup.1 is hydrogen or fluorine; and R.sup.2 is: in which n is 0, 1 or 2; with a compound selected from a group consisting of mixing partners; and to methods of controlling or preventing damage to plants and infestations of animals; and to formulations, concentrates and seed treatments comprising such combinations.

##STR00001##

Claims

1. A composition comprising, as component (A), a compound of formula (I): ##STR00018## wherein: R.sup.1 is hydrogen or fluorine; and R.sup.2 is: ##STR00019## wherein n is 0, 1 or 2; or a salt thereof; and, as component (B), at least one compound selected from the group consisting of: B-1 (S)-N-[[2-fluoro-4-[2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropanecarboxamide (CAS 2044701-44-0) B-2 N-[[2-fluoro-4-[2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropanecarboxamide (CAS 1365070-72-9) B-3 spidoxamat (CAS 907187-07-9) B-4 fenmezoditiaz (CAS 2413390-32-4) B-5 3-(2-chlorothiazol-5-yl)-8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-8-ium-7-olate (CAS 2413839-57-1) B-6 (3R)-3-(2-chlorothiazol-5-yl)-8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-8-ium-7-olate, enolate tautomer (CAS 2413839-58-2) B-7 (3R)-3-(2-chlorothiazol-5-yl)-8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-8-ium-7-olate, diketone (CAS 2246757-58-2) B-8 1-[6-(2,2-difluoro-7-methyl-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-5-ethylsulfonyl-3-pyridyl]cyclopropanecarbonitrile (CAS 2408220-94-8) B-9 2-[3-ethylsulfonyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine (CAS 2133042-44-9) B-10 2-[3-ethylsulfonyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine (CAS 2133042-31-4) B-11 (3-ethylsulfonyl-2-pyridyl)-5-(2,2,3,3,3-pentafluoropropoxy)pyrazine (CAS 2095470-94-1) B-12 2-[3-ethylsulfonyl-6-(1,2,4-triazol-1-yl)-2-pyridyl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine (CAS 1808115-49-2) B-13 carbosulfan (CAS 55285-14-8) B-14 1-(2-cyanoethyl)-4-oxo-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate (CAS 2032403-97-5) B-15 2-(5-cyclopropyl-3-ethylsulfonyl-2-pyridyl)-5-(trifluoromethylsulfonyl)-1,3-benzoxazole (CAS 2128706-05-6) B-16 6-(5-cyclopropyl-3-ethylsulfonyl-2-pyridyl)-2,2-difluoro-7-methyl-[1,3]dioxolo[4,5-f]benzimidazole (CAS 2408220-91-5) B-17 azocyclotin (CAS 41083-11-8) B-18 pyrimidifen (CAS 105779-78-0) B-19 fluacrypyrim (CAS 229977-93-9) B-20 diflovidazin (CAS 162320-67-4) B-21 (R)-(2Z)-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (CAS 2377084-09-6) B-22 2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (CAS 1445684-82-1) B-23 (2Z)-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (CAS 1445683-71-5) B-24 4-dimethyl-2-[2-(3-pyridyl)indazol-5-yl]-1,2,4-triazolidine-3,5-dione (CAS 2171099-09-3) B-25 N-[3-chloro-1-(3-pyridyl)pyrazol-4-yl]-2-methylsulfonyl-propanamide (CAS 2396747-83-2) B-26 lepimectin (CAS 863549-51-3) B-27 milbemectin (CAS 1799297-76-9 and CAS 51596-10-2) B-28 cyproflanilide (CAS 2375110-88-4) B-29 thiocyclam (CAS 31895-21-3) B-30 guadipyr (CAS 1227849-60-6) B-31 5-[[(1R,3R)-3-[3,5-bis(trifluoromethyl)phenyl]-2,2-dichloro-cyclopropanecarbonyl]amino]-2-chloro-N-[3-[(2,2-difluoroacetyl)amino]-2,4-difluoro-phenyl]benzamide) (CAS 2220132-55-6) B-32 5-[[trans-3-[3,5-bis(trifluoromethyl)phenyl]-2,2-dichloro-cyclopropanecarbonyl]amino]-2-chloro-N-[3-[(2,2-difluoroacetyl)amino]-2,4-difluoro-phenyl]benzamide B-33 afoxolaner (CAS 1093861-60-9) B-34 fluralaner (CAS 864731-61-3) B-35 sarolaner (CAS 1398609-39-6) B-36 ivermectin (CAS 70288-86-7) B-37 tigolaner (CAS 1621436-41-6) B-72 oxathiapiprolin B-73 iprodione B-74 fludioxonil B-75 mefenoxam or metalaxyl-M B-76 metalaxyl B-77 penflufen B-78 fluindapyr B-79 penthiopyrad B-80 furametpyr B-81 pydiflumetofen B-82 sedaxane B-83 thiabendazole B-84 mefentrifluconazole B-85 prothioconazole B-86 triticonazole B-87 flutriafol B-88 difenconazole B-89 ipconazole B-90 azoxystrobin B-91 fluoxastrobin B-92 picarbutrazox B-93 amisulbrom B-94 cyazofamid B-95 hymexazole B-96 fluopicolide B-97 fluoxapiprolin B-98 cyprodinil B-99 thiram B-100 florylpicoxamid B-101 fenamidone B-102 famoxadone B-103 oxadixyl B-104 acibenzolar-S-methyl B-105 boscalid B-106 bixafen B-107 fluopyram B-108 fluxapyroxad B-109 isoflucypram B-110 flutolanil B-111 pyraziflumid B-112 pyrapropoyne B-113 inpyrfluxam B-114 carboxin B-115 zoxamide B-116 thiophanate-methyl B-117 ethaboxam B-118 dimethomorph B-119 metconazole B-120 prochloraz B-121 tebuconazole B-122 triadimenol B-123 fluquinconazole B-124 myclobutanil B-125 imazalil B-126 oxpoconazole B-127 cyproconazole B-128 pyraclostrobin B-129 picoxystrobin B-130 enestrobin B-131 fenaminostrobin B-132 mandestrobin B-133 metyltetraprole B-134 fluazinam B-135 quinofumelin B-136 cyflufenamid (CAS 180409-60-3) B-137 ipflufenoquin B-138 cymoxanil and B-139 copper or salts thereof.

2. A composition according to claim 1 wherein the ratio by weight of (A) to (B) is from 500:1 to 1:500, 100:1 to 1:100, 50:1 to 1:50 or 20:1 to 1:20, or preferably 10:1 to 1:10 or 5:1 to 1:5; more preferably 3.1 to 1:3.

3. A composition comprising, as component (A), a compound of formula (I): ##STR00020## wherein: R.sup.1 is hydrogen or fluorine; and R.sup.2 is: ##STR00021## wherein n is 0, 1 or 2; or a salt thereof; and, as component (B), at least one compound selected from the group consisting of: B-38 afidopyropen (CAS 915972-17-7) B-39 flonicamid (CAS 158062-67-0) B-40 fluxametamide (CAS 928783-29-3) B-41 spirotetramat (CAS 203313-25-1) B-42 triflumezopyrim (CAS 1263133-33-0) B-43 broflanilide (CAS 1207727-04-5) B-44 nicofluprole (CAS 1771741-86-6) B-45 spinetoram (CAS 935545-74-7) B-46 thiacloprid (CAS 111988-49-9) B-47 flupyradifurone (CAS 951659-40-8) B-48 imidacloprid (CAS 138261-41-3) B-49 sulfoxaflor (CAS 946578-00-3) B-50 acetamiprid (CAS 135410-20-7) B-51 nitenpyram (CAS 150824-47-8) B-52 clothianidin (CAS 210880-92-5) B-53 thiamethoxam (CAS 153719-23-4) B-54 tetraniliprole (CAS 1229654-66-3) B-55 flubendiamide (CAS 272451-65-7) B-56 chlorantraniliprole (CAS 500008-45-7) B-57 cyantraniliprole (CAS 736994-63-1) B-58 oxazosulfyl (CAS 1403615-77-9) B-59 indoxacarb (CAS 173584-44-6) B-60 cyfluthrin (CAS 68359-37-5) B-61 deltamethrin (CAS 52918-63-5) B-62 acrinathrin (CAS 101007-06-1) B-63 zeta-cypermethrin (CAS 1315501-18-8) B-64 bifenthrin (CAS 82657-04-3) B-65 gamma-cyhalothrin (CAS 76703-62-3) B-66 alpha-cypermethrin (CAS 67375-30-8) B-67 permethrin (CAS 52645-53-1) B-68 fenpropathrin (CAS 39515-41-8) B-69 fenvalerate (CAS 51630-58-1) B-70 esfenvalerate (CAS 66230-04-4) B-71 lambda-cyhalothrin (CAS 91465-08-6) B-140 isocycloseram (CAS 2061933-85-3) B-141 tefluthrin (CAS 79538-32-2) B-143 dimpropyridaz (CAS 1403615-77-9) and B-144 fipronil (CAS 120068-37-3) or salts thereof; wherein the composition comprises (A) and (B) in a ratio by weight of 500:1 to 1:500, 100:1 to 1:100, 50:1 to 1:50, or 20:1 to 1:20, 10:1 to 1:10; 5:1 to 1:5; or 3.1 to 1:3 by weight.

4. A composition according to any one of claims 1 to 3 further comprising one or more auxiliaries and/or diluents.

5. A method of controlling or preventing damage to a plant, which comprises applying, in any desired sequence or simultaneously, on the plant, the locus thereof or its propagation material, comprising, as component (A), a compound of formula (I): ##STR00022## wherein: R.sup.1 is hydrogen or fluorine; and R.sup.2 is: ##STR00023## wherein n is 0, 1 or 2; or an agrochemically acceptable salt thereof; and, as component (B), at least one compound selected from the group consisting of B-1 (S)-N-[[2-fluoro-4-[2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropanecarboxamide (CAS 2044701-44-0) B-2 N-[[2-fluoro-4-[2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropanecarboxamide (CAS 1365070-72-9) B-3 spidoxamat (CAS 907187-07-9) B-4 fenmezoditiaz (CAS 2413390-32-4) B-5 3-(2-chlorothiazol-5-yl)-8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-8-ium-7-olate (CAS 2413839-57-1) B-6 (3R)-3-(2-chlorothiazol-5-yl)-8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-8-ium-7-olate, enolate tautomer (CAS 2413839-58-2) B-7 (3R)-3-(2-chlorothiazol-5-yl)-8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-8-ium-7-olate, diketone (CAS 2246757-58-2) B-8 1-[6-(2,2-difluoro-7-methyl-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-5-ethylsulfonyl-3-pyridyl]cyclopropanecarbonitrile (CAS 2408220-94-8) B-9 2-[3-ethylsulfonyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine (CAS 2133042-44-9) B-10 2-[3-ethylsulfonyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine (CAS 2133042-31-4) B-11 (3-ethylsulfonyl-2-pyridyl)-5-(2,2,3,3,3-pentafluoropropoxy)pyrazine (CAS 2095470-94-1) B-12 2-[3-ethylsulfonyl-6-(1,2,4-triazol-1-yl)-2-pyridyl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine (CAS 1808115-49-2) B-13 carbosulfan (CAS 55285-14-8) B-14 1-(2-cyanoethyl)-4-oxo-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate (CAS 2032403-97-5) B-15 2-(5-cyclopropyl-3-ethylsulfonyl-2-pyridyl)-5-(trifluoromethylsulfonyl)-1,3-benzoxazole (CAS 2128706-05-6) B-16 6-(5-cyclopropyl-3-ethylsulfonyl-2-pyridyl)-2,2-difluoro-7-methyl-[1,3]dioxolo[4,5-f]benzimidazole (CAS 2408220-91-5) B-17 azocyclotin (CAS 41083-11-8) B-18 pyrimidifen (CAS 105779-78-0) B-19 fluacrypyrim (CAS 229977-93-9) B-20 diflovidazin (CAS 162320-67-4) B-21 (R)-(2Z)-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (CAS 2377084-09-6) B-22 2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (CAS 1445684-82-1) B-23 (2Z)-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (CAS 1445683-71-5) B-24 4-dimethyl-2-[2-(3-pyridyl)indazol-5-yl]-1,2,4-triazolidine-3,5-dione (CAS 2171099-09-3) B-25 N-[3-chloro-1-(3-pyridyl)pyrazol-4-yl]-2-methylsulfonyl-propanamide (CAS 2396747-83-2) B-26 lepimectin (CAS 863549-51-3) B-27 milbemectin (CAS 1799297-76-9 and CAS 51596-10-2) B-28 cyproflanilide (CAS 2375110-88-4) B-29 thiocyclam (CAS 31895-21-3) B-30 guadipyr (CAS 1227849-60-6) B-31 5-[[(1R,3R)-3-[3,5-bis(trifluoromethyl)phenyl]-2,2-dichloro-cyclopropanecarbonyl]amino]-2-chloro-N-[3-[(2,2-difluoroacetyl)amino]-2,4-difluoro-phenyl]benzamide) (CAS 2220132-55-6) B-32 5-[[trans-3-[3,5-bis(trifluoromethyl)phenyl]-2,2-dichloro-cyclopropanecarbonyl]amino]-2-chloro-N-[3-[(2,2-difluoroacetyl)amino]-2,4-difluoro-phenyl]benzamide B-33 afoxolaner (CAS 1093861-60-9) B-34 fluralaner (CAS 864731-61-3) B-35 sarolaner (CAS 1398609-39-6) B-36 ivermectin (CAS 70288-86-7) B-37 tigolaner (CAS 1621436-41-6) B-72 oxathiapiprolin B-73 iprodione B-74 fludioxonil B-75 mefenoxam or metalaxyl-M B-76 metalaxyl B-77 penflufen B-78 fluindapyr B-79 penthiopyrad B-80 furametpyr B-81 pydiflumetofen B-82 sedaxane B-83 thiabendazole B-84 mefentrifluconazole B-85 prothioconazole B-86 triticonazole B-87 flutriafol B-88 difenconazole B-89 ipconazole B-90 azoxystrobin B-91 fluoxastrobin B-92 picarbutrazox B-93 amisulbrom B-94 cyazofamid B-95 hymexazole B-96 fluopicolide B-97 fluoxapiprolin B-98 cyprodinil B-99 thiram B-100 florylpicoxamid B-101 fenamidone B-102 famoxadone B-103 oxadixyl B-104 acibenzolar-S-methyl B-105 boscalid B-106 bixafen B-107 fluopyram B-108 fluxapyroxad B-109 isoflucypram B-110 flutolanil B-111 pyraziflumid B-112 pyrapropoyne B-113 inpyrfluxam B-114 carboxin B-115 zoxamide B-116 thiophanate-methyl B-117 ethaboxam B-118 dimethomorph B-119 metconazole B-120 prochloraz B-121 tebuconazole B-122 triadimenol B-123 fluquinconazole B-124 myclobutanil B-125 imazalil B-126 oxpoconazole B-127 cyproconazole B-128 pyraclostrobin B-129 picoxystrobin B-130 enestrobin B-131 fenaminostrobin B-132 mandestrobin B-133 metyltetraprole B-134 fluazinam B-135 quinofumelin B-136 cyflufenamid (CAS 180409-60-3) B-137 ipflufenoquin B-138 cymoxanil and B-139 copper or agrochemically acceptable salts thereof.

6. A composition according to claim 1 or claim 2 or a method according to claim 5 wherein component (B) further comprises at least one compound selected from B-38 afidopyropen (CAS 915972-17-7) B-39 flonicamid (CAS 158062-67-0) B-40 fluxametamide (CAS 928783-29-3) B-41 spirotetramat (CAS 203313-25-1) B-42 triflumezopyrim (CAS 1263133-33-0) B-43 broflanilide (CAS 1207727-04-5) B-44 nicofluprole (CAS 1771741-86-6) B-45 spinetoram (CAS 935545-74-7) B-46 thiacloprid (CAS 111988-49-9) B-47 flupyradifurone (CAS 951659-40-8) B-48 imidacloprid (CAS 138261-41-3) B-49 sulfoxaflor (CAS 946578-00-3) B-50 acetamiprid (CAS 135410-20-7) B-51 nitenpyram (CAS 150824-47-8) B-52 clothianidin (CAS 210880-92-5) B-53 thiamethoxam (CAS 153719-23-4) B-54 tetraniliprole (CAS 1229654-66-3) B-55 flubendiamide (CAS 272451-65-7) B-56 chlorantraniliprole (CAS 500008-45-7) B-57 cyantraniliprole (CAS 736994-63-1) B-58 oxazosulfyl (CAS 1403615-77-9) B-59 indoxacarb (CAS 173584-44-6) B-60 cyfluthrin (CAS 68359-37-5) B-61 deltamethrin (CAS 52918-63-5) B-62 acrinathrin (CAS 101007-06-1) B-63 zeta-cypermethrin (CAS 1315501-18-8) B-64 bifenthrin (CAS 82657-04-3) B-65 gamma-cyhalothrin (CAS 76703-62-3) B-66 alpha-cypermethrin (CAS 67375-30-8) B-67 permethrin (CAS 52645-53-1) B-68 fenpropathrin (CAS 39515-41-8) B-69 fenvalerate (CAS 51630-58-1) B-70 esfenvalerate (CAS 66230-04-4) B-71 lambda-cyhalothrin (CAS 91465-08-6) B-140 isocycloseram (CAS 2061933-85-3) B-141 tefluthrin (CAS 79538-32-2) B-142 cyclobutrifluram (CAS 1644251-74-0) B-143 dimpropyridaz (CAS 1403615-77-9) and B-144 fipronil (CAS 120068-37-3) or agrochemically acceptable salts thereof.

7. A method of controlling or preventing damage to a plant, which comprises applying, in any desired sequence or simultaneously, on the plant, the locus thereof or its propagation material, comprising, as component (A), a compound of formula (I): ##STR00024## wherein: R.sup.1 is hydrogen or fluorine; and R.sup.2 is: ##STR00025## wherein n is 0, 1 or 2; or an agrochemically acceptable salt thereof; and, as component (B), a compound selected from the group consisting of B-38 afidopyropen (CAS 915972-17-7) B-39 flonicamid (CAS 158062-67-0) B-40 fluxametamide (CAS 928783-29-3) B-41 spirotetramat (CAS 203313-25-1) B-42 triflumezopyrim (CAS 1263133-33-0) B-43 broflanilide (CAS 1207727-04-5) B-44 nicofluprole (CAS 1771741-86-6) B-45 spinetoram (CAS 935545-74-7) B-46 thiacloprid (CAS 111988-49-9) B-47 flupyradifurone (CAS 951659-40-8) B-48 imidacloprid (CAS 138261-41-3) B-49 sulfoxaflor (CAS 946578-00-3) B-50 acetamiprid (CAS 135410-20-7) B-51 nitenpyram (CAS 150824-47-8) B-52 clothianidin (CAS 210880-92-5) B-53 thiamethoxam (CAS 153719-23-4) B-54 tetraniliprole (CAS 1229654-66-3) B-55 flubendiamide (CAS 272451-65-7) B-56 chlorantraniliprole (CAS 500008-45-7) B-57 cyantraniliprole (CAS 736994-63-1) B-58 oxazosulfyl (CAS 1403615-77-9) B-59 indoxacarb (CAS 173584-44-6) B-60 cyfluthrin (CAS 68359-37-5) B-61 deltamethrin (CAS 52918-63-5) B-62 acrinathrin (CAS 101007-06-1) B-63 zeta-cypermethrin (CAS 1315501-18-8) B-64 bifenthrin (CAS 82657-04-3) B-65 gamma-cyhalothrin (CAS 76703-62-3) B-66 alpha-cypermethrin (CAS 67375-30-8) B-67 permethrin (CAS 52645-53-1) B-68 fenpropathrin (CAS 39515-41-8) B-69 fenvalerate (CAS 51630-58-1) B-70 esfenvalerate (CAS 66230-04-4) B-71 lambda-cyhalothrin (CAS 91465-08-6) B-140 isocycloseram (CAS 2061933-85-3) B-141 tefluthrin (CAS 79538-32-2) B-143 dimpropyridaz (CAS 1403615-77-9) and B-144 fipronil (CAS 120068-37-3) or agrochemically acceptable salts thereof; wherein the composition comprises component (A) and the or each compound of component (B) in a ratio by weight of 500:1 to 1:500, 100:1 to 1:100, 50:1 to 1:50, or 20:1 to 1:20, 10:1 to 1:10; 5:1 to 1:5; or 3.1 to 1:3 by weight.

8. The method according to any one of claims 5 to 7, wherein the rate of application of component (A) is 1 to 2000 g/ha, especially from 10 to 1000 g/ha, more especially from 20 to 200 g/ha; and the rate of application of the or each compound of component (B) is 1 to 2000 g/ha, especially from 10 to 1000 g/ha, more especially from 20 to 200 g/ha.

9. A method of controlling or preventing infestation of an animal, which comprises applying, in any desired sequence or simultaneously, on the animal a combination comprising, as component (A), a compound of formula (I): ##STR00026## wherein: R.sup.1 is hydrogen or fluorine; and R.sup.2 is: ##STR00027## wherein n is 0, 1 or 2; as defined above or a pharmaceutically or veterinary acceptable salt thereof; and, as component (B), at least one compound selected from the group consisting of B-33 afoxolaner (CAS 1093861-60-9) B-34 fluralaner (CAS 864731-61-3) B-35 sarolaner (CAS 1398609-39-6) B-36 ivermectin (CAS 70288-86-7) and B-37 tigolaner (CAS 1621436-41-6) or pharmaceutically or veterinary acceptable salts thereof.

10. The use of a combination comprising, as component (A), a compound of formula (I): ##STR00028## wherein: R.sup.1 is hydrogen or fluorine; and R.sup.2 is: ##STR00029## wherein n is 0, 1 or 2; or a pharmaceutically or veterinary acceptable salt thereof; and, as component (B), at least one compound selected from the group consisting of: B-33 afoxolaner (CAS 1093861-60-9) B-34 fluralaner (CAS 864731-61-3) B-35 sarolaner (CAS 1398609-39-6) B-36 ivermectin (CAS 70288-86-7) and B-37 tigolaner (CAS 1621436-41-6) or pharmaceutically or veterinary acceptable salts thereof, in controlling or preventing infestation of an animal.

11. The use of a composition as claimed in any one of claims 1 to 4 or claim 6 as an insecticide, acaricide and/or nematicide or for controlling insect, acarina and/or nematode pests.

12. The method according to any one of claims 5 to 9 or the use of claim 10 or claim 11 wherein the combination is applied in succession or simultaneously or as a composition comprising (A) and (B).

13. The method according to any one of claims 5 to 9 or claim 12 or the use according to any one of claims 10 to 12, wherein the combination controls one or more pests selected from insect, acarina, nematode and fungal pests.

14. A composition as claimed in any one of claims 1 to 4 or claim 6, or a method as claimed in any one of claims 5 to 9 or claim 12 or claim 13, or a use as claimed in any one of claims 10 to 13 wherein the compound of formula (I) is a compound of formula (I) in which R.sup.1 is hydrogen and R.sup.2 is ##STR00030##

15. A composition as claimed in any one of claims 1 to 4 or claim 6, or a method as claimed in any one of claims 5 to 9 or claims 12 to 14, or a use as claimed in any one of claims 10 to 14 wherein the compound of formula (I) is a compound of formula (I) in which R.sup.1 is hydrogen and R.sup.2 is ##STR00031##

16. A composition as claimed in any one of claims 1 to 4 or claim 6, or a method as claimed in any one of claims 5 to 9 or claims 12 to 15, or a use as claimed in any one of claims 10 to 15 wherein the compound of formula (I) is a compound of formula (I) in which R.sup.1 is fluorine and R.sup.2 is ##STR00032## wherein n is 0, 1 or 2.

17. A composition as claimed in any one of claims 1 to 4 or claim 6, or a method as claimed in any one of claims 5 to 9 or claims 12 to 16, or a use as claimed in any one of claims 10 to 16 wherein the compound of formula (I) is ##STR00033##

18. A formulation comprising a composition as claimed in any one of claims 1 to 4, claim 6 or claims 14 to 17, the formulation comprising from 0.01 to 90% by weight of active agents, from 0 to 25% by weight of agriculturally or pharmaceutically acceptable surfactant and from 10 to 99.9 percent by weight of solid or liquid formulation inerts and adjuvants.

19. A concentrate composition for dilution by a user, the concentrate composition comprising a composition as claimed in any one of claims 1 to 4, claim 6 or claims 14 to 17, comprising from 2% to 80% by weight, preferably between about 5% and 70% by weight, of active agents.

Description

BIOLOGICAL EXAMPLES

[0420] The synergistic biological activity of combinations of component (A) and component (B) as disclosed herein was assessed using a Myzus persicae (Green peach aphid) feeding assay. Test compounds prepared from 10000 ppm DMSO stock solutions were applied by pipette into 24-well microtiter plates and mixed with sucrose solution. The plates were closed with a stretched Parafilm. A plastic stencil with 24 holes was placed onto the plate and pea seedlings infested with a Myzus persicae population of mixed ages were placed directly on the Parafilm. The infested plate was closed with a gel blotting paper and another plastic stencil and then turned upside down. The samples were assessed for mortality 5 days after infestation.

TABLE-US-00012 Component A Component B A-1 B-3 Mortality (%) [AI] (mg/L) [AI] (mg/L) Expected (%) Observed (%) 0.375 0.312 75 75 0.188 0.156 75 62 0.094 0.078 50 37 0.047 0.039 25 0 0.188 0.625 62 75 0.094 0.312 37 62 0.047 0.156 0 37 0.094 1.25 37 50 0.047 0.625 0 25 0.023 0.312 0 0 Component A Component B A-1 B-11 Mortality (%) [AI] (mg/L) [AI] (mg/L) Expected (%) Observed (%) 0.375 0.047 75 75 0.188 0.023 62 75 0.094 0.012 35 37 0.047 0.006 0 25 0.188 0.094 62 75 0.094 0.047 35 37 0.047 0.023 0 12 0.023 0.012 0 12 0.094 0.188 35 62 0.047 0.094 0 25 0.023 0.047 0 0 0.012 0.023 0 0 0.047 0.375 75 75 0.023 0.188 0 25 0.012 0.094 0 0 0.006 0.047 0 0 Component A Component B A-1 B-46 Mortality (%) [AI] (mg/L) [AI] (mg/L) Expected (%) Observed (%) 0.375 0.013 75 75 0.188 0.006 62 75 0.094 0.003 35 37 0.047 0.002 0 12 0.094 0.05 42 75 0.047 0.025 0 12 0.023 0.013 0 0 0.094 0.2 100 100 0.047 0.1 62 75 0.023 0.05 12 37 Component A Component B A-1 B-54 Mortality (%) [AI] (mg/L) [AI] (mg/L) Expected (%) Observed (%) 0.375 0.006 75 75 0.188 0.003 62 75 0.094 0.002 37 50 0.047 0.001 0 25 0.188 0.013 62 75 0.094 0.006 37 50 0.047 0.003 0 12 0.023 0.002 0 0 0.094 0.025 84 75 0.047 0.013 0 12 0.023 0.006 0 0 Component A Component B A-1 B-64 Mortality (%) [AI] (mg/L) [AI] (mg/L) Expected (%) Observed (%) 0.188 0.312 62 62 0.094 0.156 35 62 0.047 0.078 0 37 0.188 1.25 62 75 0.094 0.625 35 50 0.047 0.312 0 0 0.188 5 62 75 0.094 2.5 35 75 0.047 1.25 0 37 0.023 0.625 0 0 0.094 10 59 75 0.047 5 0 62 0.023 2.5 0 37 0.012 1.25 0 0 Component A Component B A-1 B-71 Mortality (%) [AI] (mg/L) [AI] (mg/L) Expected (%) Observed (%) 0.375 2.5 75 75 0.188 1.25 62 75 0.094 0.625 35 37 0.047 0.312 0 25 0.188 5 62 75 0.094 2.5 35 62 0.047 1.25 0 25 0.023 0.625 0 0 0.094 10 83 75 0.047 5 0 75 0.023 2.5 0 37 0.012 1.25 0 0