DISINFECTANT LIQUID, PREPARATION METHOD THEREOF AND FILM LAYER

Abstract

The disclosure provides a disinfectant liquid capable of realizing long-lasting and effective disinfection and sterilization, a preparation method therefor and a film layer. The disinfectant liquid comprises: an active chlorine source accounting for 0.05-20 wt % of the total weight of the disinfectant liquid; an active chlorine stabilizer accounting for 0.05-20 wt % of the total weight of the disinfectant liquid; and a pH buffering agent accounting for 0.05-5 wt % of the total weight of the disinfectant liquid, so that the disinfectant liquid has a pH between 5.5 and 9.0. The disinfectant liquid can provide active chlorine at a stable concentration for a long time, or can sustainably release active chlorine for a long time, thereby providing the function of sustainably and effectively killing various viruses, bacteria, molds, fungi and spores for a long time.

Claims

1. A disinfectant liquid, wherein the disinfectant liquid is an aqueous disinfectant liquid, comprising: an active chlorine source accounting for 0.05-20 wt % of the total weight of the disinfectant liquid, which is selected from a group consisting of sodium hypochlorite, sodium dichloroisocyanurate, dichlorodimethylhydantoin, bromochlorohydantoin, chloramine-T and chloramine-B; an active chlorine stabilizer accounting for 0.05-20 wt % of the total weight of the disinfectant liquid, which is selected from a group consisting of a piperidine-type compound and a sulfonamide compound; and a pH buffering agent accounting for 0.05-5 wt % of the total weight of the disinfectant liquid, so that the disinfectant liquid has a pH between 5.5 and 9.0.

2. The disinfectant liquid according to claim 1, wherein the pH buffering agent is selected from a group consisting of phosphoric acid, boric acid, salicylic acid and citric acid.

3. The disinfectant liquid according to claim 1, wherein the active chlorine stabilizer is selected from a group consisting of piperidine, tetramethylpiperidinol, hydroxypiperidine, piperidinecarbinol, p-toluenesulfonamide, benzene sulfonamide, and any combination thereof.

4. The disinfectant liquid according to claim 1, wherein the disinfectant liquid further comprises at least one of the following ingredients: a film-forming protective agent accounting for 0.05-5 wt % of the total weight of the disinfectant liquid; and a synergistic enhancer accounting for 0.05-5 wt % of the total weight of the disinfectant liquid.

5. The disinfectant liquid according to claim 4, wherein the film-forming protective agent is selected from a group consisting of methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose, ethyl cellulose, benzyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, cyanoethyl cellulose, benzyl cyanoethyl cellulose, carboxymethyl hydroxyethyl cellulose, phenyl cellulose, polyvinylpyrrolidone, polyacrylic acid, polyacrylamide, polyethylene glycol, polyvinyl alcohol, polymaleic anhydride and polyquaternium salts.

6. The disinfectant liquid according to claim 4, wherein the synergistic enhancer is selected from a group consisting of sodium lauryl sulfate, sodium dodecyl sulfonate and sodium dodecyl benzene sulfonate.

7. The disinfectant liquid according to claim 1, wherein the disinfectant liquid satisfies at least one of the following conditions: (1) the pH of the disinfectant liquid is close to neutral, between 6.0 and 8.0; (2) the disinfectant liquid sustainably releases active chlorine for at least 2 months, or even for 6 months or more; (3) the disinfectant liquid has no strong smell or corrosiveness; (4) the disinfectant liquid forms a thin film on a solid surface after drying, and the thin film maintains the function of sustainably and effectively killing viruses, bacteria, molds, fungi and spores for at least 2 months, or even 6 months.

8. A method for preparing the disinfectant liquid according to claim 1, wherein the method comprises: (1) adding the active chlorine source and the active chlorine stabilizer to water and stirring it uniformly; (2) optionally, adding the film-forming stabilizer and/or the synergistic enhancer to the aqueous solution obtained in step (1), and stirring it uniformly; (3) adding the pH buffering agent to make the pH of the solution to be between 5.5 and 9.0.

9. A film layer, wherein the film layer is a thin film formed on a solid surface by the disinfectant solution according to claim 1.

10. The film layer according to claim 9, wherein the film layer satisfies at least one of the following conditions: (1) the film layer remains sustainably and effectively releasing active chlorine for at least 2 months, or even 6 months; (2) the film layer has the function of killing of viruses, bacteria, molds, fungi and spores for at least 2 months, or even 6 months.

Description

DETAILED DESCRIPTION

[0027] The sources of raw materials in the following examples are listed below.

[0028] Chloramine-B, sodium hypochlorite, sodium dichloroisocyanurate, dichlorodimethylhydantoin, chloramine-T, piperidine, tetramethylpiperidinol, hydroxypiperidine, piperidinecarbinol, p-toluenesulfonamide, methyl cellulose, hydroxyethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyquaternium salts, sodium lauryl sulfate, sodium dodecyl sulfonate, sodium dodecyl benzene sulfonate, phosphoric acid, boric acid, citric acid and other raw materials were obtained from Sinopharm Chemical Reagent Co., Ltd.

[0029] The detection methods in the following examples are listed below.

[0030] The detection of active chlorine content was carried out according to GB19106-2003.

[0031] The tests for Bacteria Killing Rate, Virus Inactivation Rate, Stability Test, Metal Corrosiveness Test, Acute Oral Toxicity Test, Single Complete Skin Irritation Test, and Mutagenicity Test were carried out according to Technical Specifications for Disinfection (2002 Edition).

Example 1

[0032]

TABLE-US-00001 Example 1 chloramine-B 10% tetramethylpiperidinol 0.2% phosphoric acid 0.1% citric acid 0.1% water balance pH value (freshly formulated) 6.87 pH value (180 days 6.96 after formulation) active chlorine 26800 mg/L (freshly formulated) active chlorine 26600 mg/L (180 days after formulation)

Example 2

[0033]

TABLE-US-00002 Example 2 chloramine-T 2% tetramethylpiperidinol 0.05% sodium dodecyl sulfonate 0.05% boric acid 0.1% water balance pH value (freshly formulated) 7.30 pH value (180 days 7.42 after formulation) active chlorine 2800 mg/L (freshly formulated) active chlorine 2830 mg/L (180 days after formulation)

Example 3

[0034]

TABLE-US-00003 Example 3 sodium dichloroisocyanurate 2% piperidine 0.05% sodium dodecyl 1% benzene sulfonate phosphoric acid 0.05% citric acid 0.05% water balance pH value 6.65 active chlorine 7420 mg/L (freshly formulated) active chlorine 7020 mg/L (180 days after formulation)

Example 4

[0035]

TABLE-US-00004 Example 4 chloramine-T 2% tetramethylpiperidinol 0.2%.sup. polyvinylpyrrolidone 2% boric acid 3% water balance pH value (freshly 6.82 formulated) pH value (180 days 7.07 after formulation) active chlorine 3100 mg/L (freshly formulated) active chlorine 2980 mg/L (180 days after formulation)

Example 5

[0036]

TABLE-US-00005 Example 5 sodium dichloroisocyanurate 20% piperidinecarbinol .sup.1% polyquaternium 0.6% sodium dodecyl sulfonate .sup.1% phosphoric acid 0.3% citric acid 0.3% water balance pH value (freshly 7.18 formulated) pH value (180 days 7.30 after formulation) active chlorine 72500 mg/L (freshly formulated) active chlorine 71800 mg/L (180 days after formulation)

Example 6

[0037]

TABLE-US-00006 Example 6 sodium hypochlorite .sup.2% tetramethylpiperidinol 0.2% p-toluenesulfonamide .sup.2% polyvinylpyrrolidone 0.5% sodium lauryl sulfate .sup.1% phosphoric acid 0.1% citric acid 0.1% water balance pH value (freshly 7.26 formulated) pH value (180 days 7.35 after formulation) active chlorine 10860 mg/L (freshly formulated) active chlorine 10520 mg/L (180 days after formulation)

Example 7

[0038]

TABLE-US-00007 Example 7 dichlorodimethylhydantoin .sup.2% hydroxypiperidine 0.5% polyvinyl alcohol .sup.1% sodium dodecyl .sup.1% benzene sulfonate phosphoric acid 0.1% citric acid 0.1% water balance pH value (freshly 6.85 formulated) pH value (180 days 7.02 after formulation) active chlorine 7360 mg/L (freshly formulated) active chlorine 7250 mg/L (180 days after formulation)

Example 8

[0039]

TABLE-US-00008 Example 8 chloramine-B 0.05% tetramethylpiperidinol 0.05% methyl cellulose 0.05% sodium lauryl sulfate 0.05% boric acid 0.05% water balance pH value (freshly 6.50 formulated) pH value (180 days 6.68 after formulation) active chlorine 116 mg/L (freshly formulated) ctive chlorine 108 mg/L (180 days after formulation)

Example 9

[0040]

TABLE-US-00009 Example 9 chloramine-T 10% tetramethylpiperidinol 0.2% hydroxyethyl cellulose 0.6% sodium lauryl sulfate 1% phosphoric acid 0.1% citric acid 0.1% water balance pH value 6.36 active chlorine 24800 mg/L stability test passed metal corrosiveness test no corrosion Acute Oral Toxicity Test nontoxic single complete skin irritation test non-irritating mutagenicity test no micronucleogenic effect Killing Rate against Staphylococcus 99.999% Aureus (diluted 10 times, action for 1 minute) Killing Rate against E. Coli 99.999% (diluted 10 times, action for 1 minute) Killing Rate against Pseudomonas 99.999% Aeruginosa (diluted 10 times, action for 1 minute) Killing Rate against Candida Albicans 99.999% (10 minutes of action) Killing Rate against Aspergillus Niger 99.999% (20 minutes of action) Killing Rate against natural bacteria 90% (20 minutes of action) Inactivation Rate against Poliovirus 99.99% Inactivation Rate against 229E Coronavirus 99.99% Killing Rate against Bacillus Subtilis 99.999% Black Variant Spores (60 minutes of action)

Example 10

[0041]

TABLE-US-00010 Example 10 chloramine-T .sup.2% tetramethylpiperidinol 0.2% hydroxyethyl cellulose 0.3% sodium dodecyl benzene sulfonate 0.05% boric acid 2.6% water balance pH value 7.10 active chlorine 3250 mg/L Killing Rate against influenza A 99.99% virus H3N2 (5 minutes)

Comparative Examples 1-2

[0042]

TABLE-US-00011 Comparative Comparative Example 3 Example 1 Example 2 sodium dichloroisocyanurate 2% 2% piperidine 0.05% 0.05% 0.05% sodium dodecyl 1% 1% benzene sulfonate phosphoric acid 0.05% 0.05% 0.05% citric acid 0.05% 0.05% 0.05% water balance balance balance pH value 6.65 6.62 6.60 active chlorine 7420 mg/L 7415 mg/L (freshly formulated) active chlorine 7020 mg/L 7030 mg/L (180 days after formulation) Killing Rate against 99.999% 82.68% 5.16% E. Coli (diluted 20 times, action for 1 minute)

Comparative Examples 3-4

[0043]

TABLE-US-00012 Example Comparative Comparative 7 Example 3 Example 4 dichlorodimethylhydantoin .sup.2% .sup.2% hydroxypiperidine 0.5% 0.5% 0.5% polyvinyl alcohol .sup.1% .sup.1% .sup.1% sodium dodecyl .sup.1% .sup.1% benzene sulfonate phosphoric acid 0.1% 0.1% 0.1% citric acid 0.1% 0.1% 0.1% water balance balance balance pH value (freshly formulated) 6.85 6.83 6.81 pH value (180 days 7.02 7.01 7.00 after formulation) active chlorine 7360 mg/L 7365 mg/L (freshly formulated) active chlorine 7250 mg/L 7260 mg/L (180 days after formulation) Killing Rate against 99.999% 81.50% 5.18% Staphylococcus Aureus (diluted 20 times, action for 1 minute)

Comparative Examples 5-6

[0044]

TABLE-US-00013 Comparative Comparative Example 10 Example 5 Example 6 chloramine-T .sup.2% .sup.2% tetramethylpiperidinol 0.2% 0.2% 0.2% hydroxyethyl cellulose 0.3% 0.3% 0.3% sodium dodecyl 0.05% 0.05% benzene sulfonate boric acid 2.6% 2.6% 2.6% water balance balance balance pH value 7.10 7.09 7.08 active chlorine 3250 mg/L 3250 mg/L Killing Rate against 99.99% 90.00% 1.26% influenza A virus H3N2 (action for 5 minutes)

[0045] In summary, the present disclosure prepares a disinfectant liquid and a film layer formed therefrom capable of effectively and sustainably killing various viruses (especially coronaviruses), bacteria, molds, fungi and spores for a long time. This disinfectant liquid or film layer can provide a stable concentration of active chlorine for a long time, or can sustainably release active chlorine for a long time, thereby achieving long-lasting and effective ability of killing various viruses (especially coronaviruses), bacteria, molds, and fungi and spores. Meanwhile, it is harmless to the human body, does not affect the environment, does not corrode items, and thus has advantages of a long expiration time, good stability and good safety.

[0046] The specific examples of the present disclosure have been described in detail above, but the disclosure is not limited to these specific examples. For those skilled in the art, any equivalent modifications and substitutions to the present disclosure are also within the scope of the present disclosure.