A COOLING PREPARATION

Abstract

Suggested is a cooling preparation comprising phenylalkenals and homovanillic acid esters.

Claims

1. A cooling preparation, comprising: (a) at least one phenylalkenal according to formula (I) ##STR00033## in which R.sub.1 and R.sub.2 independently of one another represent hydrogen, a methyl or phenyl residue, R.sub.3 stands for hydrogen, a phenyl, an alkenyl or a linear or branched alkyl residue with 1 to 5 carbon atoms, and the broken double lines represent, independently of one another, a single bond or a double bond, (b) at least one homovanillic acid ester according to formula (II) ##STR00034## wherein (i) R.sup.1 and R.sup.2 stand, irrespective of each other, for a hydrogen atom or an alkyl residue with 1-2 carbon atoms, R.sup.3 and R.sup.4 stand, irrespective of each other, for a hydrogen atom or a linear or branched alkyl residue with 1 to 5 carbon atoms, a phenyl residue, an alkylphenyl residue or a phenylalkyl residue or a linear or branched alkenyl residue with 2 to 4 carbon atoms or an alkenylphenyl residue or a phenylalkenyl residue, or (ii) R.sup.1 and R.sup.3 along with the carbon atoms linking them form a cyclohexyl ring, which may be substituted by an additional residue R.sup.5, wherein R.sup.5 is an alkyl residue with 1-2 carbon atoms, R.sup.2 is a hydrogen atom or an alkyl residue with 1-2 carbon atoms, R.sup.4 stands for a hydrogen atom or a linear or branched alkyl residue with 1 to 5 carbon atoms, a phenyl residue, an alkylphenyl residue or a phenylalkyl residue or a linear or branched alkenyl residue with 2 to 4 carbon atoms or an alkenylphenyl residue or a phenylalkenyl residue, or a physiologically acceptable salt thereof, wherein the phenolic hydroxy group in formula (I) is deprotonated, or a mixture, comprising one or more different compounds of formula (I) and/or one or more physiologically acceptable salts thereof, wherein each of the phenolic hydroxy group in formula (II) is deprotonated, or consists of a plurality of different compounds of formula (II) and/or salts thereof, wherein each of the phenolic hydroxy group in formula (II) is deprotonated, and optionally (c) at least one physiological cooling agent different from components (a) and (b).

2. The preparation of claim 1, comprising phenylalkenals of formula (I), in which R.sub.1 and R.sub.2 are different and denote hydrogen or phenyl, R.sub.3 stands for hydrogen, an alkenyl or a linear or branched alkyl group with 1 to 5 carbon atoms, and the broken double lines represent, independently of one another, a single bond or a double bond.

3. The preparation of claim 1, wherein the phenylalkenals of formula (I), which are selected from the group consisting of: TABLE-US-00056 No. Name Formula I-1 2-Phenyl-but-2-enal I-2 2-Phenyl-pent-2-enal I-3 3-Phenyl-pent-4-enal I-4 2-Phenyl-pent-4-enal

4. The preparation of claim 1, comprising homovanillic acid esters of formula (II), wherein R.sup.4 represents a hydrogen atom or a linear or branched alkyl residue with 1 to 5 carbon atoms, a phenyl residue, an alkylphenyl residue or a phenylalkyl residue or a linear or branched alkenyl residue with 2 to 4 carbon atoms, or an alkenylphenyl residue or a phenylalkylene residue, or a physiologically acceptable salt thereof.

5. The preparation of claim 1, comprising homovanillic acid esters of formula (II), wherein (i) R.sup.1 and R.sup.2 stand, irrespective of each other, for a hydrogen atom or methyl group, R.sup.3 and R.sup.4 stand, irrespective of each other, for a hydrogen atom or a linear or branched alkyl residue with 1 to 5 carbon atoms or a phenyl residue, an alkylphenyl residue or a phenylalkyl residue or an alkenylphenyl residue or a phenylalkenyl residue, or (ii) formula (II) corresponds to the following formula (lIa) ##STR00039## wherein R.sup.2 stands for a hydrogen atom, and R.sup.4 stands for 2-propyl.

6. The preparation of claim 1, comprising homovanillic acid esters of formula (II), wherein R.sup.1 and R.sup.2 each stand for a hydrogen atom, R.sup.3 stands for a hydrogen atom or a linear or branched alkyl residue with 1 to 4 carbon atoms or a phenyl residue, an alkylphenyl residue or a phenylalkyl residue or an alkenylphenyl residue or a phenylalkenyl residue, R.sup.4 stands for a hydrogen atom.

7. The preparation of claim 1, wherein said homovanillic acid esters are selected from the group consisting of: TABLE-US-00057 o. Name Formula I-1 2-phenylethyl-2-(4- hydroxy-3-methoxyphenyl) acetate 1 I-2 [(E)-cinnamyl]-2-(4- hydroxy-3-methoxyphenyl) acetate 2 I-3 1-ethylbutyl-2-(4-hydroxy- 3-methoxyphenyl) acetate 3 I-4 3-methylbut-2-enyl-2-(4- hydroxy-3-methoxyphenyl) acetate 4 I-5 [(E)-hex-2-enyl]-2-(4- hydroxy-3-methoxyphenyl) acetate 5 I-6 [(Z)-hex-3-enyl]-2-(4- hydroxy-3-methoxyphenyl) acetate 6 I-7 Isopropyl-2-(4-hydroxy-3- methoxy-phenyl) acetate 7 I-8 sec-butyl-2-(4-hydroxy-3- methoxyphenyl) acetate 8 I-9 Isobutyl-2-(4-hydroxy-3- methoxy-phenyl) acetate 9 I-10 1,1-dimethylpropyl 2-(4- hydroxy-3-methoxyphenyl) acetate 10 I-11 Isopentyl-2-(4-hydroxy-3- methoxyphenyl) acetate 11 I-12 2-methylbutyl-2-(4- hydroxy-3-methoxyphenyl) acetate 12 I-13 1-methylpentyl-2-(4- hydroxy-3-methoxyphenyl) acetate 13 I-14 Heptyl-2-(4-hydroxy-3- methoxyphenyl) acetate 14 I-15 1-methylhexyl-2-(4- hydroxy-3-methoxyphenyl) acetate 15 I-16 (2-isopropyl-5-methyl- cyclohexyl)-2-(4-hydroxy-3- methoxyphenyl) acetate 16 I-17 Propyl-2-(4-hydroxy-3- methoxyphenyl) acetate 17 I-18 Ethyl-2-(4-hydroxy-3- methoxyphenyl) acetate 18 I-19 Butyl-2-(4-hydroxy-3- methoxyphenyl) 19 I-20 Pentyl-2-(4-hydroxy-3- methoxyphenyl) acetate 20 I-21 Hexyl-2-(4-hydroxy-3- methoxyphenyl) acetate 21 I-22 3-phenylpropyl 2-(4- hydroxy-3-methoxyphenyl) acetate 22 I-23 4-phenylbutyl 2-(4- hydroxy-3-methoxyphenyl) acetate 23

8. The preparation of claim 1, further comprising as component (c) physiological cooling agents selected from the group consisting of menthol and menthol derivatives, menthylethers, menthylesters, menthylcarbonates, the semi-esters of menthols with a dicarboxylic acid or derivatives thereof, menthanecarboxylic acid amides, menthone and menthone derivatives, 2,3-dimethyl-2-(2-propyl)-butyric acid derivatives, isopulegol or its esters, menthane derivatives, cubebol or synthetic or natural mixtures containing cubebol, pyrrolidone derivatives of cycloalkyldione derivatives or tetrahydropyrimidine-2-one oxamates and mixtures thereof.

9. The preparation of claim 7, wherein said addition physiological cooling agent are selected from the group consisting of menthol, menthyl lactate, menthyl acetate and L-menthone glycerol acetal/ketal and mixtures thereof.

10. The preparation of claim 1, comprising: (a) about 1:99 to about 99:1 wt.-percent at least one phenylalkenal according to formula (I); and (b) about 99:1 to about 1:99 wt.-percent at least one homovanillic acid esters of formula (II), on condition that the amounts add to 100 wt.-percent.

11. The preparation of claim 1, comprising: (a) about 0.2:2 to about 2:0.2 wt.-percent at least one phenylalkenal according to formula (I); (b) about 2:0.2 to about 0.2:2 wt.-percent at least one homovanillic acid esters of formula (II), and (c) up to 97.8 wt.-percent additional physiological cooling agents others than components (a) and (b), on condition that the amounts add to 100 wt.-percent.

12. A cosmetic and/or personal care composition comprising the cooling preparation of claim 1.

13. An oral composition comprising the cooling preparation of claim 1.

14. A method of providing a cooling sensation to human skin comprising the steps of: (a) providing a cooling preparation according to claim 1, and (b) applying said cooling preparation topically to human skin.

15. A method of providing a cooling sensation to a human mucous membrane comprising the steps of: (a) providing a cooling preparation according to claim 1, and (b) administering said preparation or composition orally.

16. A method comprising using a preparation according to claim 1 for making cosmetic, personal care or oral compositions.

17. The preparation of claim 4, wherein R.sup.4 represents the linear or branched alkyl residue with 1 to 5 carbon atoms, which is selected from the group consisting of methyl, ethyl, 1-propyl, 2 propyl, 1-butyl, 2-butyl, tert-butyl, 2-methylprop-1-yl, 1-, 2- or 3-pentyl, 2-methylbut-1-yl, 2-methylbut-2-yl, 3-methylbut-1-yl und 3-methylbut-2-yl, preferably methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, tert-butyl, 2-methylprop-1-yl and 1-pentyl.

18. The preparation of claim 4, wherein R.sup.4 represents the linear or branched alkenyl residue with 2 to 4 carbon atoms, which is selected from the group consisting of ethenyl, prop-2-en 1-yl, prop-1-en-1-yl, prop-1-en-2-yl, 1- or 2-cyclopropenyl, but-1-en-1-yl, but-1-en-2-yl, 4 but-1-en-3-yl, but-2-en-1-yl, but-3-en-1-yl, but-2-en-2-yl, 2-methylprop-1-en-1-yl, 2 methylprop-2-en-1-yl, 1,3-butadien-1-yl, 1,3-butadien-2-yl, and the possible Z and E isomers in each case.

Description

EXAMPLES

Example 1

Long Lasting Cooling Sensation

[0326] Phenylalkennals and homovanillic acid esters were added alone and in combination to a standard toothpaste composition. A panel of 5 experienced testers evaluated the compositions with regard to initial cooling effect during brushing, directly after brushing and the long last effect after 5 and after 10 minutes. The evaluation was done according to a score card from 1=almost no cooling effect to 10=strong cooling sensation. The results are provided in Table 1. Example 1 is according to the invention, examples C1 to C3 serve for comparison.

TABLE-US-00003 TABLE 1 Cooling sensation Composition C1 C2 C3 1 Phenylbutenal — 0.02 — 0.02 Homovanillic acid propylphenyl — — 0.05 0.05 ester 5% in propyleneglycol Solbrol M (sodium salt) 0.15 0.15 0.15 0.15 Sodium monofluor phosphate 0.76 0.76 0.76 0.76 Saccharin 0.2 0.2 0.2 0.2 Mint aroma (Optamint ® 232772) 1.00 1.00 1.00 1.00 Dicalciumphosphate dihydrate 36.00 36.00 36.00 36.00 Aerosil 200 3.00 3.00 3.00 3.00 Sodium carboxymethyl cellulose 1.20 1.20 1.20 1.20 Sodium lauryl sulfate 1.30 1.30 1.30 1.30 Glycerol 5.00 5.00 5.00 5.00 Deionised water Ad 100 Cooling sensation Initial cooling during brushing 5 6 5 6 Directly after brushing 6 7 6 7 After 5 minutes 3 3 3 5 After 10 minutes 1 1 1 3
Phenylbutenal and homovanillic acid propylphenyl ester 5% in propylene glycol are obtainable in the market from Symrise AG.
Adding phenylbutenal to standard toothpaste improves the cooling sensation during and directly after brushing, but does not have any long lasting effect. Homovanillic acid propylphenyl ester 5% in propylene glycol provides a warming agent and does not have any effect when added alone.
Combining phenylbutenal and homovanillic acid propylphenyl ester, however, leads to a serious improvement in long lasting cooling sensation, both when determined after 5 and after 10 minutes.

Formulation Examples for Cosmetic Compositions

[0327] The following examples F1 to F59 show various formulations for cosmetic and oral compositions. Formulation 1 stands for a mixture of menthol 48%, phenylbutenal 1.6% and homovanillic acid propylphenyl ester 0.2% and 51.2% of a flavor or fragrance composition.

TABLE-US-00004 TABLE F1 Liquid soap; transparent (Amounts in % b.w.) Ingredients INCI Name Amount Tagat O 2 PEG-20 Glyceryl Oleate 2.5 Coconut oil diethanolamine Cocamide DEA 5.0 condensate Abil B 8842 Cyclomethicone 0.5 Sodium laurylethersulfate. Sodium Laureth Sulfate 35.0 28% Tego-Betaine L7 Cocamidopropy Betaine 5.0 Soap. 25% Coconut acid. Potassium 20.0 salt. Potassium Oleate Hydrolite ® 5 1,2-propanediol 0.4 Formulation 1 0.3 Water Water Ad 100

TABLE-US-00005 TABLE F2 Syndet soap. liquid (Amounts in % b.w.) Ingredients INCI Name Amount Elfan OS 46 Sodium Olefin C14-C16 Sulfonate 35.5 Armoteric LB Lauryl Betaine 8.0 Elfan SG 10.0 Elfacos GT 282 L Talloweth-60 Myristyl Glycol 3.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 4.0 Hydrolite ® 5 Green Hydrolite ® 5 Green 0.4 Preservative Methylchloroisothiazolinone 0.1 Formulation 1 0.4 Water Water Ad 100

TABLE-US-00006 TABLE F3 Cosmetic lotion for body wash (Amounts in % b.w.) Ingredients INCI Name Amount Lumerol K 28 Disodium Laureth Sulfosuccinate. 33.0 Cocamidopropyl Betaine. Magnesium Lauryl Sulfate Amphotensid B 4 Cocamidopropyl Betaine 10.0 Perlglanzmittel MIPA-Pareth-25 Sulfate. 4.0 GM 4055 Glycol Stearate Sodium Chloride Sodium Chloride 2.0 Avocado oil Persea Gratissima (Avocado) Oil 3.0 Water Water Ad 100 Hydrolite ® 5 Hydrolite ® 5 Green 0.5 Euxyl ® K727 Phenoxyethanol. Methyldibromo 0.3 Glutaronitrile. Isothiazolinones Formulation 1 0.6

TABLE-US-00007 TABLE F4 Cosmetic lotion for body wash with Triclosan (Amounts in % b.w.) Ingredients INCI Name Amount Texapon N 25 Sodium Laureth Sulfate 37.5 Lamepon S Potassium Cocoyl Hydrolyzed Collagen 28.0 Lamesoft LMG Hydrogenated Tallow Glycerides. TEA- 5.0 Cocoyl Hydrolyzed Collagen Lamesoft 156 Glyceryl Laurate. TEA-Cocoyl 5.0 Hydrolyzed Collagen Sodium Chloride Sodium Chloride 1.7 Irgasan DP 300 Triclosan 0.5 Water Water Ad 100 Hydrolite ® 5 Hydrolite ® 5 Green 0.3 Euxyl ® K703 Phenoxyethanol. Benzoic Acid. 0.4 Dehydroacetic Acid Formulation 1 0.4

TABLE-US-00008 TABLE F5 Intimate wash (Amounts in % b.w.) Ingredients INCI Name Amount Tegobetaine HS Cocamidopropyl Betaine. Glyceryl 15.0 Laurate Tagat L 2 PEG-20 Glyceryl Laurate 2.0 Arlacide G Chlorhexidine Digluconate 0.1 Rewoquat B 50 Benzalkonium Chloride 0.1 Lactic Acid. 80% Lactic Acid 0.1 Water Water Ad 100 Hydrolite ® 5 Hydrolite ® 5 Green 0.2 Euxyl ® K700 Potassium Sorbate. Benzyl Alcohol. 0.3 Phenoxyethanol Formulation 1 0.5

TABLE-US-00009 TABLE F6 Liquid soap (Amounts in % b.w.) Ingredients INCI Name Amount Deionized water Water 2.0 Soap bases mix Sodium tallowates/palmitates 95.8 Titanium dioxide Titanium dioxide 1.0 Hydrolite ® 5 Hydrolite ® 5 Green 1.2 Preservatives Phenoxyethanol 0.5 Formulation 1 0.5

TABLE-US-00010 TABLE F7 Shampoo (Amounts in % b.w.) Ingredients Amount Sodium lauryl ether sulfate (e.g. Texapon NSO) 12 Cocamidopropyl betaine (e.g. Dehyton K) 2 Sodium chloride 1.4 Citric acid 1.3 1,2-pentanediol (Hydrolite ® 5) 0.3 Phenoxyethanol. methyl-. ethyl-. butyl- and propylparaben 0.5 Formulation 1 0.5 Water Ad 100

TABLE-US-00011 TABLE F8 2-in-l Shampoo (Amounts in % b.w.) Ingredients INCI Name Amount Deionized water Water Ad 100 Plantacare PS 10 Sodium Laureth Sulfate. Lauryl 20.0 Glucoside Euperlan PK 771 Glycol Distearate. Sodium Lauryl 6.0 Sulfate. Cocamide MEA. Laureth-10 Sodium chloride Sodium Chloride 1.4 Citric acid monohydrate Citric acid 0.1 crystalline Hydrolite ® 5 Hydrolite ® 5 Green 0.5 Dragocid Liquid Phenoxyethanol, Parabens 0.5 Formulation 1 0.5

TABLE-US-00012 TABLE F9 Anti-dandruff Shampoo (Amounts in % b.w.) Ingredients Amount Climbazole 0.50 Sodium Laureth Sulfate 37.00 Cocamidopropyl Betaine 8.00 PEG-6 Caprylic/Capric Glycerides 2.50 Laureth-2 2.00 Water (Aqua). Glycerol. Thymus Vulgaris (Thyme). Flower/Leaf Extract 0.50 Rosmarinus Officinalis (Rosemary) Leaf Water. Water (Aqua). Butylene Glycol. 0.50 Pentylene Glycol Bisabolol 0.10 Panthenol 0.50 Polyquaternium-10 0.40 1,2-pentanediol (Hydrolite ® 5) 0.50 Phenoxyethanol. Methylparaben. Ethylparaben. Butylparaben. Propylparaben. 0.70 Isobutylparaben Formulation 1 0.30 Water (Aqua) Ad 100

TABLE-US-00013 TABLE F10 Hair conditioner with Crinipan. rinse-off (Amounts in % b.w.) Ingredients INCI Name Amount Lanette ® 0 Cetearyl Alcohol 4.00 Dragoxat 89 Ethylhexyl Isononanoate 2.00 GenaKDM-Pmin ® Behentrimonium Chloride 1.00 SF1550 Phenyl Trimethicone 0.10 Neo Heliopan ® Benzophenone-3 0.10 BB Crinipan ® AD Climbazole 0.80 Glycerol 99.5 P. Glycerol 6.00 Water Water (Aqua) Ad 100 Actipone ® Water (Aqua). Butylene 0.50 Glycol. Malic Acid. Alpha Pulp Actinidia Chinensis (Kiwi) Fruit Juice. Citrus. Aurantium Dulcis (Orange). Juice. Citrus Paradisi (Grapefruit) Juice. Pyrus Malus (Apple) Juice. Trideceth-9. PrunusAmygdalus Dulcis (Sweet Almond) Seed Extract Extrapone ® Propylene Glycol. Water (Aqua). 0.50 Butylene Glycol. Bamboo P Bambusa Vulgaris Shoot Extract Sodium Sodium Hydroxide 0.40 Hydroxide 10% solution Colour 1 Colour 0.60 Colour II Colour 0.30 Hydrolite ® 5 Hydrolite® 5 Green 0.40 Preservative Methylparaben 0.20 Formulation 1 Hydroxyacetophenone 0.70

TABLE-US-00014 TABLE F11 Sprayable hair conditioner with zinc pyrithrione. leave-on (Amounts in % b.w.) Ingredients INCI Name Amount Monomuls 60-35 C Hydrogenated Palm Glycerides 1.70 Cetiol OE Dicaprylyl Ether 7.20 Abil 100 Dimethicone 3.60 Dehyquart F 75 Distearoylethyl 4.00 Hydroxyethylmonium. Methosulfate. Cetearyl Alcohol Eumulgin Bl Ceteareth-12 3.50 Cetiol S Diethylhexylcyclohe xane 7.20 D-Panthenol Panthenol 0.10 Glycerol 99.5 P. Glycerol 1.50 Water Water (Aqua) Ad 100 Actipone ® Rosemary Water (Aqua). Propylene. 0.10 Glycol. Rosmarinus Officinalis. (Rosemary) Leaf Extract Frescolat ® ML Cryst. Menthyl Lactate 0.50 Dragosantol100 Bisabolol 0.10 Zinc Omadine Zinc pyrithione 0.10 Hydrolite ® 5 Hydrolite ® 5 0.40 Phenonip ® phenoxyethanol, methylparaben, 0.30 ethylparaben, butylparaben, propylparaben, isobutylparaben Formulation 1 0.5

TABLE-US-00015 TABLE F12 Hair conditioner with UV protection (Amounts in % b.w.) Ingredients 1 NCI Name Amount Renex PEG 6000 PEG-150 2.50 Hair Conditioner Base Cetyl alcohol, behentrimonium 3.00 chloride. Triticum Vulgare (Wheat) bran extract, linoleic acid PCL-Solid Stearyl heptanoate. stearyl caprylate 0.50 Dow Corning 5200 Laurylmethicone copolyol 0.50 Natrosol 250 HR Hydroxyethylcellulose 0.50 Benzophenone-4 Benzophenone-4 1.00 Neo Heliopan AP Disodiumphenyldibenz-imidazole 1.00 tetrasulphonate Amino methyl propanol Amino methyl propanol 2.00 Dow Corning 949 cationic Amodimethicone. cetrimonium 2.00 emulsion chloride, trideceth-12 Hydrolite ® 5 Hydrolite ® 5 0.80 1.2-hexanediol 1.2-hexanediol 0.50 Formulation 1 0.50 Water Water (Aqua) Ad 100

TABLE-US-00016 TABLE 13 Shower gel (Amounts in % b.w.) Ingredients INCI Amount Deionized water Water Ad 100 Plantacare PS 10 Sodium Laureth Sulfate. 20.0 Lauryl Glucoside Sodium chloride Sodium Chloride 1.4 Citric acid monohydrate Citric Acid 1.3 crystalline Hydrolite ® 5 Hydrolite ® 5 0.6 SymDiol ®68 1,2-hexanediol. 0.4 Caprylyl glycol Formulation 1 0.4

TABLE-US-00017 TABLE F14 Shaving foam (Amounts in % b.w.) Ingredients Amount Dem. Water 77.2 Triethanolamine 4.0 Edenor L2 SM (Stearinic acid. Palmitinic acid) (Cognis) 5.3 Laureth-23 3.0 Stearylalcohol 0.5 Sodium lauryl sulfate 3.0 Extrapone Seaweed (water, propylene glycol, potassium iodide. Fucus Vesiculosus 1.0 Extract) Dragosantol (Bisabolol. Farnesol) 0.1 1,2-pentanediol (Hydrolite ® 5) 1.0 Euxyl ® K220 (Methylisothiazolinone. Ethylhexylglyerol) 0.6 Formulation 1 0.3 Propane, butane 4.2 Bar 4.0

TABLE-US-00018 TABLE F15 Depilatory cream (Amounts in % b.w.) Ingredients Amount Cetearyl alcohol 10.0 Ceteareth-12 2.0 PCL-Liquid (Cetearylethylhexanoate. Isopropylmyristate) 3.0 Dragosantol (Bisabolol. Farnesol) 0.1 Edenor L2 SM (Stearinic acid. Palmitinic acid) 1.0 Dem. Water 52.2 Urea 5.0 Dem. Water 10.0 Calcium thioglycolate 6.0 Sodium hydroxide solution. 10 % 10.0 1,2-pentanediol (Hydrolite ® 5) 0.5 Neo Dragocid Powder (Methyl parabene, sorbinic acid. Dehydro acetic acid. Propyl 0.2 parabene) Formulation 1 0.4

TABLE-US-00019 TABLE F16 After Shave Tonic (Amounts in % b.w.) Ingredients INCI Amount SymSol ® PF-3 Water (Aqua). Pentylene Glycol. Sodium Lauryl 3.00 Sulfoacetate. SodiumOleoyl Sarcosinate. Sodium Chloride. Disodium Sulfoacetate. SodiumOleate. Sodium Sulfate SymSitive ® 1609 Pentylene Glycol. 4-t-Butylcyclohexan ol 1.00 Frescolat ® ML Menthyl Lactate 0.30 Glycerol 99.5 P. Glycerol 5.00 Water Water (Aqua) Ad 100 Extrapone ® Glacier Water Glycerol. Water (Aqua) 1.00 GW Sym Calmin ® Butylene Glycol. Pentylene Glycol. Hydroxyphenyl 0.50 Propamidobenzoic Acid Dragosine ® Carnosine 0.10 Hydrolite ® 5 Pentylene Glycol 5.00 Ethanol 96% Alcohol Denat. 5.00 Colour Pigment Colour Pigment 0.05 Hydrolite ® 5 1,2-pentanediol 0.15 Formulation 1 Hydroxyacetophenone 1.00

TABLE-US-00020 TABLE F17 Deodorant formulation in the form of a roll-on gel (Amounts in % b.w.) Ingredients Amount 1.3-butylene glycol 2.00 PEG-40-hydrogenated castor oil 2.00 Hydroxyethylcellulose 0.50 1,2-pentanediol (Hydrolite ® 5) 0.30 1.3-propanediol 0.50 3-phenylpropanol 0.40 Ethylhexyl glycerin 0.10 Formulation 1 0.50 Water ad 100.00

TABLE-US-00021 TABLE F18 Clear deo anti-perspirant roll-on (Amounts in % b.w.) Ingredients INCI Amount Methocel E4M Premium Hydroxypropyl Methylcellulose 0.50 Water Water (Aqua) Ad 100 Neo-PCL Water Soluble N Trideceth-9. PEG-5 Ethylhexanoate. Water 1.00 (Aqua) Solubilizer PEG-40 Hydrogenated Castor Oil. Trideceth- 3.00 9. Propylene Glycol. Water (Aqua) Deolite Dimethyl Phenylpropanol. Pentylene Glycol 0.50 Locron LW Aluminium Chlorohydrate 25.00 Aloe Vera Gel Concentrate 10/1 Aloe Barbadensis Leaf Juice 1.00 Propylene Glycol −1.2 99 P GC Propylene Glycol 4.00 Ethanol 96 % Alcohol Denat. 30.00 Hydrolite ® 5 l,2pentanediol 1.00 Formulation 1 Hydroxyacetophenone 0.25

TABLE-US-00022 TABLE F19 Deodorant stick (Amounts in % b.w.) Ingredients Amount Sodium stearate 8.00 PPG-3 Myristyl ether 70.00 1,2-propylene glycol 10.00 1,1-dimethyl-3-phenylpropanol 0.20 2-butyloctanoic acid 0.20 1,2-pentanediol (Hydrolite ® 5) 0.60 Heptoxy-1,2-propanediol 0.20 Phenoxyethanol 0.30 Formulation 1 0.50 Water Ad 100

TABLE-US-00023 TABLE F20 Zirconium suspensoid antiperspirant stick (Amounts in % b.w.) Ingredients INCI Amount PCL Liquid 100 Cetearyl ethylhexanonate to 100 Silicone Fluid 345 Cyclomethicone 10.00 CRODACOLC90 Cetyl Alcohol 8.00 SYNCROWAX HGLC C18-36 Triglyceride 8.00 CRODAMOL PTC Pentaerythritol Tetracaprylate/Ca prate 5.00 SYNCROWAX HRC Tribehenin 4.00 VOLPO N5 Oleth-5 1.00 Titanium Dioxide 1.00 Rezal 36GP Aluminium Tetrachlorohydrex GLY 20.00 Dry Flo C Aluminium Starch Octenyl Succinate 22.50 Hydrolite ® 5 1,2-pentanediol 0.60 Preservative Phenoxyethanol 0.40 Hexoxy-1.2-propanediol 0.10 Formulation 1 0.40

TABLE-US-00024 TABLE F21 Deodorant pump spray with SymClariol (Amounts in % b.w.) Ingredients INCI Amount SymClariol ® Decylene Glycol 0.50 Solubilizer PEG-40 Hydrogenated Castor 4.00 Oil. Trideceth-9. Propylene Glycol. Water (Aqua) Neo-PCL Water Trideceth-9. PEG-5 1.50 Soluble N Ethylhexanoate. Aqua Sym Relief ® Bisabolol. Zingiber Officinale 0.10 (Ginger) Root Extract Water Water (Aqua) Ad 100 1.2 Propylene Glycol Propylene Glycol 6.00 Hydrolite ® 5 1,2-pentanediol 0.40 SymDiol ® 68 1.2-Hexanediol. Caprylyl Glycol 0.20 Formulation 1 0.40

TABLE-US-00025 TABLE F22 Antiperspirant formulations (Amounts in % b.w.) Ingredients Amounts Reach AZP-908SUF 24.00 Cyclomethicone (Pentamer) Ad 100 Polydecene (Silkflo 364 NF) 17.50 Neo Heliopan OS (ethylhexyl salicylate) 2.50 L-Menthyl lactate (Frescolate ML) 0.25 Polyethylene 3.00 Hydrogenated castor oil 2.00 Promyristyl PM-3 7.00 PEG-8 Distearate 3.00 Silicon dioxide (Cab-O-Sil M-5) 1.00 Stearyl alcohol 15.00 Octyldodecanol 0.10 1,2-pentanediol (Hydrolite ® 5) 0.80 3-Phenylpropanol 0.40 Formulation 1 0.60

TABLE-US-00026 TABLE F23 Deodorant spray with Triclosan (Amounts in % b.w.) Ingredients Amount PEG-40-hydrogenated castor oil 3.00 Ethylhexylglycerol (Octoxyglycerol) 0.80 Ethanol 40.00 Citrate buffer 0.50 Triclosan ® (5-chloro-2-(2.4-dichlorophenoxy) 0.25 phenol) 1,2-pentanediol (Hydrolite ® 5) 0.75 Phenoxyethanol 0.40 Formulation 1 0.40 Water Ad 100

TABLE-US-00027 TABLE F24 O/W lotion (Amounts in % b.w.) Ingredients Amount Paraffin oil 5.00 Isopropyl palmitate 5.00 Cetyl alcohol 2.00 Beeswax 2.00 Ceteareth-20 2.00 PEG-20-glyceryl stearate 1.50 Glycerol 3.00 1,2-pentanediol (Hydrolite ® 5) 0.30 Methyl paraben 0.30 Formulation 1 0.60 Water ad 100.00

TABLE-US-00028 TABLE F25 Body lotion (Amounts in % b.w.) Ingredients Amount Cetearyl Alcohol 2.00 Ethylhexyl Isononanoate 5.00 Cetearyl Ethylhexanoate. Isopropyl Myristate 3.00 Glyceryl Oleate Citrate. Caprylic/Capric Triglyceride 4.00 Water (Aqua) 79.50 Carbomer 0.30 Sodium Benzoate 0.100 Propylene Glycol 5.00 Sodium Hydroxide 30% solution 0.30 1,2-pentanediol (Hydrolite ® 5) 0.30 Triethylene Glycol. Imidazolidinyl Urea. 0.30 Methylparaben. Propylparaben. Dehydroacetic Acid Formulation 1 0.20

TABLE-US-00029 TABLE F26 Cream (Amounts in % b.w.) Ingredients Amount Paraffin oil 10.00 Ozokerite 4.00 Vaseline 4.00 Vegetable oil 10.00 Wool wax alcohol 2.00 Aluminum stearate 0.40 1,2-pentanediol (Hydrolite ® 5) 2.00 Phenoxyethanol 0.50 Formulation 1 0.50 Water ad 100.00

TABLE-US-00030 TABLE F27 Cream (Amounts in % b.w.) Ingredients INCI Amount Dracorin ® CE Glyceryl Stearate Citrate 1.00 Lanette ® O Cetearyl Alcohol 2.00 Cutina ® GMS-V Glyceryl Stearate 1.00 Tegosoft ® MM Myristyl Myristate 1.00 Xiameter ® PMX-0246. Cyclosiloxane Cyclohexasiloxane (and) Cyclopentasiloxane 0.50 Dragoxat ® 89 Ethylhexyl Isononanoate 2.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 4.00 Neutral Oil Caprylic/Capric Triglyceride 4.00 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 0.20 Keltrol ® CG-T Xanthan Gum 0.10 Water Water (Aqua) Ad 100 Glycerol 99.5 P. Glycerol 3.00 Propylene Glycol-1.2 99 P GC Propylene Glycol 2.00 Sodium Benzoate Sodium Benzoate 0.10 Sodium Hydroxide 10% solution Sodium Hydroxide 0.50 Hydrolite ® 5 1,2-pentanediol 0.30 Euxyl ® K702 Dehydroacetic Acid. Benzoic Acid. 0.30 Phenoxyethanol.Polyaminopropyl Biguanide. Ethylhexylglycerin Formulation 1 0.70

TABLE-US-00031 TABLE F28 Hand and body cream (Amounts in % b.w.) Ingredients INCI Amount Dracorin ® GOC Glyceryl Oleate Citrate. Caprylic/Capric 2.00 Triglyceride PCL-Solid Stearyl Heptanoate. Stearyl Caprylate 2.50 Lanette ® O Cetearyl Alcohol 1.50 Cutina ® GMS-V Glyceryl Stearate 1.00 Dragoxat ® 89 Ethylhexyl Isononanoate 3.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 7.00 Isodragol ® Triisononanoin 4.00 Xiameter ® PMX-0345 Cyclosiloxane Cyclopentasiloxane (and) Cyclohexasiloxane 0.50 Water Water (Aqua) Ad 100 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 0.20 Keltrol ® CG-RD Xanthan Gum 0.10 Glycerol 85 P. Glycerol 3.00 DragoBetaGlucan Water (Aqua). Butylene Glycol. Glycerol. Avena 1.50 Sativa (Oat) Kernel Extract Potassium Sorbat Potassium Sorbate 0.10 Sodium Hydroxide 10% solution Sodium Hydroxide 0.50 Hydrolite ® 5 1,2-pentanediol 0.20 Euxyl ® K300 Methyl-. Butyl-. Ethyl-. Propyl. Isobutylparaben. 0.30 Phenoxyethanol. Formulation 1 0.30

TABLE-US-00032 TABLE F29 Face cream (Amounts in % b.w.) Ingredients INCI Amount Emulsiphos ® Potassium Cetyl Phosphate. Hydrogenated Palm 1.50 Glycerides Cutina ® GMS-V Glyceryl Stearate 1.70 Lanette ® O Cetearyl Alcohol 3.00 Tegosoft ® MM Myristyl Myristate 1.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 1.00 Isodragol ® Triisononanoin 3.00 Dragoxat ® 89 Ethylhexyl Isononanoate 4.00 Avocado Oil Persea Gratissima (Avocado) Oil 3.00 Abil ® 350 Dimethicone 0.50 Covi-ox ® T-70 Tocopherol 0.10 Edeta ® BD Disodium EDTA 0.10 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 0.30 Keltrol ® CG-RD Xanthan Gum 0.150 Water Water (Aqua) Ad 100 Glycerol 99.5 P. Glycerol 4.00 Propylene Glycol-1.2 99 P GC Propylene Glycol 3.00 Sym Matrix ® Maltodextrin. Rubus Fruticosus (Blackberry) 0.50 Leaf Extract Sodium Hydroxide 10% solution Sodium Hydroxide 0.50 Hydrolite ® 5 1,2-pentanediol 0.30 Euxyl ® K712 Sodium Benzoate. Potassium Sorbate 0.20 Formulation 1 0.60

TABLE-US-00033 TABLE F30 Moisturizing body care cream (Amounts in % b.w.) Ingredient Amount PEG-7 hydrogenated castor oil 6.00 Cetearyl ethyl hexanoate 10.00 Isopropyl myristate 5.00 Mineral oil 7.00 Shea Butter (Butyrospermum parkii) 0.50 Aluminum stearate 0.50 Magnesium stearate 0.50 Bisabolol 0.20 Quaternium-18-Hectorit 0.70 Dipropylene glycol 5.0 Magnesium sulfate 0.70 1,2-pentanediol (Hydrolite ® 5) 4.00 Preservative (Phenoxyethanol) 0.20 Formulation 1 0.40 Aqua dem. 58.90

TABLE-US-00034 TABLE F31 Anti-wrinkle cream (Amounts in % b.w.) Ingredients Amount Glyceryl Stearate Citrate 1.00 Glyceryl Laurate 1.00 Cetearyl Alcohol (and) Myristyl Myristate 3.00 Cetearyl Ethylhexanoate 4.00 Mineral oil 4.00 Cyclohexasiloxane 0.50 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 0.20 Water Ad 100 1.2-Hexanediol 2.00 Sodium Hydroxide 10% solution 0.10 Narcissus Tazetta Bulb Extract 1.00 1,2-pentanediol (Hydrolite ® 5) 0.30 Preservative (Phenoxyethanol) 0.50 Formulation 1 0.50

TABLE-US-00035 TABLE F32 Functional skin oil for disinfection (Amounts in % b.w.) Ingredients INCI Amount Neutral Oil Caprylic/Capric Triglyceride Ad 100 Sweet Almond Oil Prunus Dulcis 20.00 Dragoxat ® 89 Ethylhexyl Isononanoate 4.00 Isopropyl Palmitate Isopropyl Palmitate 6.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 15.00 Dragosantol ® 100 Bisabolol 0.20 Retinyl Acetate In Oil (1 Mio. le/G) Retinyl Acetate 0.50 Vitamin E Acetate Tocopheryl Acetate 0.50 Covi-ox ® T-70 Tocopherol 0.10 Hydrolite ® 5 1,2-pentanediol 0.30 Preservative Methyl-. Butyl-. Ethyl-. 0.30 Propylparaben Formulation 1 0.40

TABLE-US-00036 TABLE F33 Septic wound cream (Amounts in % b.w.) Ingredients (INCI) Amount Sorbitan Isostearate. Hydrogenated 6.00 Castor Oil. Ceresin. Beeswax (Cera Alba) Petrolatum 21.00 Cera Alba 5.00 Cetearyl Alcohol 7.00 Prunus Dulcis 7.00 Lanolin 5.00 Paraffinum Liquidum 12.00 Water (Aqua) Ad 100 Panthenol 7.00 Magnesium Sulfate 0.70 1,2-pentanediol (Hydrolite ® 5) 1.00 Tocopheryl Acetate 1.00 Octenidine dihydrochloride 0.10 Phenoxyethanol 0.50 Formulation 1 0.50

TABLE-US-00037 TABLE F34 Moisturizing and disinfecting face mask (Amounts in % b.w.) Ingredients INCI Amount Water Water (Aqua) Ad 100 Stabileze QM PVM/Ma Decadiene Crosspolymer 0.50 Biotive ® L-Arginine Arginine 0.75 Actipone ® Laminaria Glycerol. Water (Aqua). 1.00 Saccharina GW Laminaria Saccharina Extract Extrapone ® Cucumber Water (Aqua). Propylene Glycol. 1.00 Cucumis Sativus (Cucumber) Juice Glycerol 99.5 P. Glycerol 7.00 Neo Actipone ® Soap Sapindus Mukurossi Peel Extract 0.50 Nutshell Colour 1 Colour 0.01 Hydrolite ® 5 Pentylene Glycol 5.00 Solubilizer PEG-40 Hydrogenated Castor Oil. 0.60 Trideceth-9. Water (Aqua) Hydrolite ® 5 1,2-pentanediol 0.08 Preservative Phenoxyethanol 0.40 Formulation 1 0.40

TABLE-US-00038 TABLE F35 Sprayable disinfecting gel (Amounts in % b.w.) Ingredients INCI Amount Water Water (Aqua) Ad 100 Stabileze QM PVM/Ma Decadiene Crosspolymer 0.25 Sodium Hydroxide 10% solution Sodium Hydroxide 0.40 Coffein pure Caffeine 0.50 Extrapone ® Horse Chestnut Propylene Glycol. Water (Aqua). Glucose. 1.00 Aescuius Hippocastanum (Horse Chestnut) Seed Extract. Lactic Acid Hydrolite ® 5 1,2-pentanediol 3.00 1.3 Butylene Glycol Butylene Glycol 5.00 Biotive ® Esculin Sesquihydrate Esculin 0.30 Ethanol 96% Alcohol Denat. 10.00 Solubilizer PEG-40 Hydrogenated Castor Oil. Trideceth-9. 0.50 Water (Aqua) Octenidine dihydrochloride 0.10 Preservative Phenoxyethanol 0.70 Formulation 1 0.30

TABLE-US-00039 TABLE F36 Mineral wash and cleaning gel (Amounts in % b.w.) Ingredients INCI Amount Water Water (Aqua) Ad 100 Pionier ® NP 37 G Sodium Carbomer 1.50 SymSol ® PF-3 Water (Aqua). Pentylene Glycol. Sodium Lauryl 5.00 Sulfoacetate. SodiumOleoyl Sarcosinate. Sodium Chloride. Disodium Sulfoacetate. SodiumOleate. Sodium Sulfate Hydroviton ® 24 Water (Aqua). Pentylene Glycol. Glycerol. 1.00 Sodium Lactate. Lactic Acid. Serine. Urea. Sorbitol. Sodium Chloride. Allantoin Extrapone ® Silk GW Water (Aqua). Glycerol. Hydrolyzed Silk 1.00 Hydrolite ® 5 Green Hydrolite ® 5 Green 4.00 Actipearls Red Star # DH10402/6 Water (Aqua). Propylene Glycol. Algin. Gellan 1.00 Gum. Xanthan Gum. CalciumChloride. CI 12490 (Pigment Red 5). Mica (CI 77019). Titanium Dioxide (CI 77891) 1,2-pentanediol (Hydrolite ® 5) 1,2-pentanediol 0.50 3-Phenylpropanol 0.70 Formulation 1 0.30

TABLE-US-00040 TABLE F37 Anti-acne wash (Amounts in % b.w.) Ingredients (INCI) Amount Water (Aqua) 45.70 Polyquaternium-7 0.50 Cocamidopropyl Betaine 9.000 9.00 Coco Glucoside 2.000 2.00 Polysorbate 80. Glycerol. Gossypium Herbaceum. 1.00 (Cotton) Seed Oil. Water (Aqua) Trideceth-9. PEG-5 Ethylhexanoate. Water (Aqua) 1.00 Glycereth-90 Isostearate. Laureth-2 0.50 Sodium Laureth Sulfate 37.000 37.00 Glycerol. Triticum Vulgare (Wheat) Gluten. Water (Aqua) 1.00 Sodium Chloride 0.30 1,2-pentanediol (Hydrolite ® 5) 1.00 Phenoxyethanol. Methylparaben. Ethylparaben. 0.30 Butylparaben. Propylparaben. Isobutylparaben Formulation 1 0.50

TABLE-US-00041 TABLE F38 Cosmetic sun protection composition (Amounts in % b.w.) Ingredient Amount Ethylhexyl cinnamic acid 7.50 Benzophenon-3 2.00 Polyglyceryl dimer soyate 0.80 Sorbitane stearate 1.00 Tocopheryl acetate 0.50 Glyceryl stearate. PEG-100 Stearate 3.00 PEG-40. hydrogenated castor oil 1.00 Titanium dioxide, aluminum oxide hydrate. 3.00 Dimethicon/Methicon Copolymer Butyrospermum parkii (Shea Butter) 1.00 C.sub.12-15 alkyl benzoate 6.50 Butylene glycol 5.00 Xanthan gum 0.30 Disodium EDTA 0.10 Allantoin 0.10 Polyacryl amide. C.sub.13-14 isoparaffin. Laureth-7 1.00 1,2-pentanediol (Hydrolite ® 5) 5.00 4-t Butylcyclohexanol 1.00 Preservatives (Methyl-. Butyl-. Ethyl-. 0.30 Propylparaben. Phenoxyethanol) Formulation 1 0.60 Aqua dem. Ad 100

TABLE-US-00042 TABLE F39 Sun protection spray (Amounts in % b.w.) Ingredients INCI Amount Water, demineralized Water (aqua) 69.50 Glycerol Glycerol 4.00 1.3 butylene glycol Butylene glycol 5.00 D-Panthenol Panthenol 0.50 Lara Care A-200 Galactoarabinan 0.25 Baysilone oil M 10 Dimethicone 1.00 Edeta BD Disodium EDTA 0.10 Copherol 1250 Tocopheryl acetate 0.50 Cetiol OE Dicaprylyl ether 3.00 Neo Heliopan ® HMS Homosalate 5.00 Neo Heliopan ® AV Ethylhexyl methoxycinnamate 6.00 Neo Heliopan ® 357 Butyl methoxydibenzoylmethane 1.00 Corapan TQ Diethylhexylnaphthalate 2.00 Alpha Bisabolol Bisabolol 0.10 Pemulen TR-2 Acrylates/C10-30 alkyl acrylate 0.25 crosspolymer NaOH. 10% Sodium hydroxide 0.60 Hydrolite ® 5 1,2-pentanediol 0.20 Phenoxyethanol Phenoxyethanol 0.40 Solbrol M Methylparaben 0.10 Solbrol P Propylparaben 0.10 Formulation 1 0.50

TABLE-US-00043 TABLE F40 Sunscreen spray O/W. SPE 15-20 (Amounts in % b.w.) Ingredients INCI Amount Dracorin ® GOC Glyceryl Oleate Citrate. 2.00 Caprylic/Capric Triglyceride Corapan ® TQ Diethylhexyl 2.6-Naphthalate 3.00 Neo Heliopan ® HMS Homosalate 7.00 Neo Heliopan ® OS Ethylhexyl Salicylate 5.00 Neo Heliopan ® 357 Butyl Methoxydibenzoylmethane 3.00 Isoadipate Diisopropyl Adipate 6.00 Baysilone ® Oil M10 Dimethicone 1.00 Edeta ® BD Disodium EDTA 0.10 Vitamin E Acetate Tocopheryl Acetate 0.50 Dragosantol ® 100 Bisabolol 0.10 Pemulen ® TR-2 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 0.25 Water Water (Aqua) Ad 100 Glycerol 99.5 P. Glycerol 4.00 Butylene Glycol Butylene Glycol 5.00 Neo Heliopan ® Hydro (103089). Phenylbenzimidazole Sulfonic Acid 8.00 used as 25% aq. solution Biotive ® L-Arginine Arginine 0.55 Hydrolite ® 5 1,2-pentanediol 0.40 Sobrol M Methylparaben 0.30 Formulation 1 0.60

TABLE-US-00044 TABLE F41 Sun protection soft cream (W/O). SPF 40 (Amounts in % b.w.) Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 dipolyhydroxystearate 5.00 Copherol 1250 Tocopheryl acetate 0.50 Permulgin 3220 Ozocerite 0.50 Zinc stearate Zinc stearate 0.50 Tegosoft TN C12-15 Alkyl benzoate 10.00 Neo Heliopan ® E1000 Isoamyl-p-methoxycinnamate 2.00 Neo Heliopan ® 303 Octocrylene 5.00 Neo Heliopan ® MBC 4-Methylbenzylidene camphor 3.00 Zinc oxide. neutral Zinc oxide 5.00 Water, distilled Water (aqua) Add 100 EDETA BD Disodium EDTA 0.10 Glycerol Glycerol 4.00 Magnesium sulfate Magnesium sulfate 0.50 Hydrolite ® 5 1,2-pentanediol 0.30 Symdiol ® 68 1.2-Hexanediol. Caprylylglycol 0.30 Formulation 1 0.80

TABLE-US-00045 TABLE F42 Sun protection milk (W/O) (Amounts in % b.w.) Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 dipolyhydroxystearate 3.00 Beeswax 8100 Beeswax 1.00 Monomuls 90-0-18 Glyceryl oleate 1.00 Zinc stearate Zinc stearate 1.00 Cetiol SN Cetearyl isononanoate 5.00 Cetiol OE Dicaprylyl ether 5.00 Tegosoft TN C12-15 alkyl benzoate 4.00 Vitamin E Tocopherol 0.50 Neo Heliopan ® OS Ethylhexyl salicylate 5.00 Neo Heliopan ® AV Ethylhexyl methoxycinnamate 7.50 Uvinul ® T150 Ethylhexyl triazone 1.50 Water. distilled Water (Aqua) To 100 Trilon BD Disodium EDTA 0.10 Glycerol Glycerol 5.00 Neo Heliopan ® AP 10% solution, Disodium phenyl dibenzimidazole 15.00 neutralized with NaOH tetrasulfonate Hydrolite ® 5 1,2-pentanediol 0.25 Alpha bisabolol Bisabolol 0.10 SymOcide ® PT Phenoxyethanol. Tropolone 0.25 Formulation 1 0.25

TABLE-US-00046 TABLE F43 After sun gel (Amounts in % b.w.) Ingredients INCI Amount SymSol ® PF-3 Water (Aqua). Pentylene Glycol. Sodium Lauryl 3.000 Sulfoacetate. SodiumOleoyl Sarcosinate. Sodium Chloride. Disodium Sulfoacetate. SodiumOleate. Sodium Sulfate Glycerol 99.5 P. Glycerol 5.000 SymHelios ® 1031 Benzylidene Dimethoxydimethylin danone 0.100 Water Water (Aqua) Ad 100 Pemulen ® TR-2 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1.000 D-Panthenol 75 W Panthenol 0.500 SymFinity ® 1298 Echinacea Purpurea Extract 0.100 Extrapone ® Pearl GW Water (Aqua). Glycerol. Hydrolyzed Pearl. 1.000 Xanthan Gum Sodium Hydroxide 10% solution Sodium Hydroxide 2.500 Ethanol 96% Alcohol Denat. 15.000 Hydrolite ® 5 1,2-pentanediol 0.20 SymOcide ® PS Phenoxyethanol. 1.2-Hexanediol. 0.50 Decyleneglycol Formulation 1 0.50

TABLE-US-00047 TABLE F44 After sun lotion (Amounts in % b.w.) Ingredients Amount Acrylate/C10-30 alkylacrylate crosspolymer 0.4 Cetearylethyl hexanoate 15.0 Bisabolol 0.2 Tocopheryl acetate 1.0 Panthenol 1.0 Alcohol 15.0 Glycerol 3.0 1.2-Hexanediol 0.60 Formulation 1 0.30 1,2-pentanediol (Hydrolite ® 5) 4.0 Aqua dem. Ad 100 Triethanolamine 0.2

TABLE-US-00048 TABLE F45 Hair styling gel (Amounts in % b.w.) Ingredients Amount Water Ad 100 PVM/MA Decadiene Crosspolymer 0.60 PVP 3.00 Isocetyl Stearate 4.00 Ethylhexyl Methoxycinnamate 0.50 Aminomethyl Propanol 0.40 1,2-pentanediol (Hydrolite ® 5) 0.60 SymDiol ® 68T (1.2-Hexanediol. 0.30 1.2-Octanediol. Tropolone) Phenoxyethanol 0.20 Formulation 1 0.40

TABLE-US-00049 TABLE F46 Silicone emulsion (Amounts in % b.w.) Ingredients Amount Potassium Cetyl Phosphate. 1.00 Hydrogenated Palm Glycerides Cyclohexasiloxane 4.00 Cetearyl Alcohol 1.50 Phenyl Trimethicone 3.00 Stearyl Heptanoate. Stearyl Caprylate 3.00 Dimethicone 1.00 Xanthan Gum 0.20 Isoamyl p-Methoxycinnamate 5.00 Water Ad 100 Methylpropanediol 3.00 1,2-pentanediol (Hydrolite ® 5) 0.30 Diazolidinyl urea 0.10 Formulation 1 0.50

TABLE-US-00050 TABLE F47 Microemulsion gel (Amounts in % b.w.) Ingredient Amount Glycerol isostearate 1.80 Octoxyglycerol 1.00 Ceteareth-15 5.20 PEG-150 Distearate 1.00 Aluminium chlorohydrate 5.00 Isotridecylisononanoate 3.30 Cyclomethicone 6.60 1,2-pentanediol (Hydrolite ® 5) 0.70 Euxyl ® K145 (Methylchloroisothiazolinone. 0.10 Methylisothiazlinone. Bronopol) Formulation 1 0.40 Water Ad 100

TABLE-US-00051 TABLE F48 Chewing gum, free of sugar; all amounts in wt.-percent Composition A1 A2 A3 Gum base 30.00 30.00 30.00 Sorbit, powdered 40.00 40.00 40.00 Isomalt, powdered 9.50 9.50 9.50 Xylitol 2.00 2.00 2.00 Mannit D 3.00 3.00 3.00 Aspartame 0.10 0.10 0.10 Acesulfam K 0.10 0.10 0.10 Emulgum/Plasticizing agent 0.30 0.30 0.30 Sorbitol (70% water) 13.00 13.00 13.00 Formulation 1 0.50 0.50 0.50 Glycerol Ad 100

TABLE-US-00052 TABLE F49 Tooth paste; all amounts in wt.-percent Composition B1 B2 B3 Deionised water 36.39 36.39 36.39 Glycerol Ad 100 Solbrol M (sodium salt) 0.15 0.15 0.15 Sodium monofluor phosphate 0.76 0.76 0.76 Saccharin 0.20 0.20 0.20 Formulation 1 0.50 0.50 0.50 Dicalciumphosphate dihydrate 36.00 36.00 36.00 Aerosil 200 3.00 3.00 3.00 Sodium carboxymethyl cellulose 1.20 1.20 1.20 Sodium lauryl sulfate 1.30 1.30 1.30

TABLE-US-00053 TABLE F50 Mouth wash concentrate; all amounts in wt.-percent Composition C1 C2 C3 Ethanol 96% 42.00 42.00 42.00 Cremophor RH 455 5.00 5.00 5.00 Deionised water 50.67 50.67 50.67 Allantoin 0.20 0.20 0.20 Sodium saccharin 450 0.10 0.10 0.10 Colour L-Blue 5000 (1% in Wasser) 0.03 0.03 0.03 Formulation 1 0.50 0.50 0.50 Flavour 2.00 2.00 2.00 Water Ad 100

TABLE-US-00054 TABLE F51 Hard boiled candy, sugar-free; all amounts in wt.-percent Composition D1 D2 D3 Isomalt 94.98 94.98 94.98 Xylitol 2.40 2.40 2.40 Sucralose 0.03 0.03 0.03 Acesulfame K 0.050 0.050 0.050 Citric acid 0.050 0.050 0.050 Formulation 1 0.50 0.50 0.50 Water Ad 100

TABLE-US-00055 TABLE F52 Hard boiled candy; all amounts in wt.-percent Composition E1 E2 E3 Water Ad 100 Glucose 60.1 94.98 94.98 Glucose syrup 36.9 2.40 2.40 Formulation 1 0.50 0.50 0.50