USE OF ADENO-ASSOCIATED VIRAL VECTORS TO CORRECT GENE DEFECTS/ EXPRESS PROTEINS IN HAIR CELLS AND SUPPORTING CELLS IN THE INNER EAR

Abstract

Provided herein are compositions that include at least two different nucleic acid vectors that, when introduced into a primate cell, the at least two different vectors undergo con catamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length target protein (e.g., a supporting cell target protein or a hair cell target protein). Also provided are compositions that include a single AAV vector that, when introduced into a primate cell, a nucleic acid encoding a full-length target protein (e.g., a supporting cell target protein or a hair cell target protein) is generated at the locus of the supporting cell target gene, and the primate expresses the target protein (e.g., a supporting cell target protein or a hair cell target protein).

Claims

1. A composition comprising at least two different nucleic acid vectors, wherein: each of the at least two different adeno-associated virus (AAV) vectors comprises a coding sequence that encodes a different portion of a supporting cell target protein, each of the encoded portions being at least 30 amino acid residues in length, wherein the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length supporting cell target protein; at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of the supporting cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length supporting cell target protein.

2. The composition of claim 1, wherein the amino acid sequence of one of the encoded portions overlaps with the amino acid sequence of a different one of the encoded portions.

3. The composition of claim 2, wherein the amino acid sequence of each of the encoded portions partially overlaps with the amino acid sequence of a different encoded portion.

4. The composition of claim 2, wherein the overlapping amino acid sequence is between 30 amino acid residues to about 390 amino acid residues in length.

5. The composition of any one of claims 1-4, wherein each of the at least two different vectors comprises a different segment of an intron, wherein the intron comprises the nucleotide sequence of an intron that is present in a supporting cell target genomic DNA, and wherein the two different segments overlap in sequence by at least 100 nucleotides.

6. The composition of claim 5, wherein the two different segments overlap in sequence by about 30 nucleotides to about 390 nucleotides.

7. The composition of any one of claims 1-6, wherein the nucleotide sequence of each of the at least two different vectors is between about 30 nucleotides to about 390 nucleotides in length.

8. The composition of claim 7, wherein the nucleotide sequence of each of the at least two different vectors is between 30 nucleotides to 340 nucleotides in length.

9. The composition of any one of claims 1-8, wherein the number of different vectors in the composition is two.

10. The composition of claim 9, wherein a first of the two different vectors comprises a coding sequence that encodes an N-terminal portion of the supporting cell target protein.

11. The composition of claim 10, wherein the N-terminal portion of the supporting cell target protein is between about 30 amino acids to about 390 amino acids in length.

12. The composition of claim 11, wherein the N-terminal portion of the supporting cell target protein is between about 30 amino acids to about 340 amino acids in length.

13. The composition of any one of claims 10-12, wherein the first vector further comprises one or both of a promoter and a Kozak sequence.

14. The composition of claim 13, wherein the first vector comprises a promoter that is an inducible promoter, a constitutive promoter, or a tissue-specific promoter.

15. The composition of any one of claims 10-14, wherein the second of the two different vectors comprises a coding sequence that encodes a C-terminal portion of the supporting cell target protein.

16. The composition of claim 15, wherein the C-terminal portion of the supporting cell target protein is between 30 amino acids to about 390 amino acids in length.

17. The composition of claim 16, wherein the C-terminal portion of the supporting cell target protein is between 30 amino acids to about 340 amino acids in length.

18. The composition of any one of claims 15-17, wherein the second vector further comprises a poly(dA) sequence.

19. A composition comprising two different nucleic acid vectors, wherein: a first nucleic acid vector of the two different nucleic acid vectors comprises a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors comprises a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; wherein each of the encoded portions is at least 30 amino acid residues in length, wherein the amino acid sequences of the encoded portions do not overlap, wherein no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

20. The composition of claim 19, wherein at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of a supporting cell target genomic DNA, and lacks an intronic sequence between the neighboring exons.

21. A composition comprising: a first nucleic acid vector comprising a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, comprising a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; wherein each of the encoded portions is at least 30 amino acid residues in length, wherein the respective amino acid sequences of the encoded portions do not overlap with each other, wherein no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

22. The composition of claim 21, wherein at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of a supporting cell target genomic DNA, and lacks an intronic sequence between the neighboring exons.

23. The composition of claim 21, wherein the first or second detectable marker gene is alkaline phosphatase.

24. The composition of claim 21 or 23, wherein the first and second detectable marker genes are the same.

25. A composition comprising: a first nucleic acid vector comprising a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, comprising a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; wherein each of the encoded portions is at least 30 amino acid residues in length, wherein the respective amino acid sequences of the encoded portions do not overlap with each other, wherein no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

26. The composition of claim 25, wherein at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of a supporting cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons.

27. A composition comprising a single adeno-associated virus (AAV) vector, wherein the single AAV vector that comprises a nucleic acid sequence that encodes a supporting cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length supporting cell target protein is generated at the locus of the supporting cell target gene, and the primate expresses the supporting cell target protein.

28. The composition of any one of claims 1-27, wherein the supporting cell target gene is gap junction protein beta 2 (GJB2).

29. The composition of any one of claims 1-27, wherein the supporting cell target gene is solute carrier family 26 member 4 (SLC26A4).

30. A composition comprising at least two different nucleic acid vectors, wherein: each of the at least two different adeno-associated virus (AAV) vectors comprises a coding sequence that encodes a different portion of a hair cell target protein, each of the encoded portions being at least 30 amino acid residues in length, wherein the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length hair cell target protein; at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of the hair cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length hair cell target protein.

31. The composition of claim 30, wherein the amino acid sequence of one of the encoded portions overlaps with the amino acid sequence of a different one of the encoded portions.

32. The composition of claim 31, wherein the amino acid sequence of each of the encoded portions partially overlaps with the amino acid sequence of a different encoded portion.

33. The composition of claim 31, wherein the overlapping amino acid sequence is between 30 amino acid residues to about 390 amino acid residues in length.

34. The composition of any one of claims 30-33, wherein each of the at least two different vectors comprises a different segment of an intron, wherein the intron comprises the nucleotide sequence of an intron that is present in a hair cell target genomic DNA, and wherein the two different segments overlap in sequence by at least 100 nucleotides.

35. The composition of claim 34, wherein the two different segments overlap in sequence by about 30 nucleotides to about 390 nucleotides.

36. The composition of any one of claims 30-35, wherein the nucleotide sequence of each of the at least two different vectors is between about 30 nucleotides to about 390 nucleotides in length.

37. The composition of claim 36, wherein the nucleotide sequence of each of the at least two different vectors is between 30 nucleotides to 340 nucleotides in length.

38. The composition of any one of claims 30-37, wherein the number of different vectors in the composition is two.

39. The composition of claim 38, wherein a first of the two different vectors comprises a coding sequence that encodes an N-terminal portion of the hair cell target protein.

40. The composition of claim 39, wherein the N-terminal portion of the hair cell target protein is between about 30 amino acids to about 390 amino acids in length.

41. The composition of claim 40, wherein the N-terminal portion of the hair cell target protein is between about 30 amino acids to about 340 amino acids in length.

42. The composition of any one of claims 39-41, wherein the first vector further comprises one or both of a promoter and a Kozak sequence.

43. The composition of claim 42, wherein the first vector comprises a promoter that is an inducible promoter, a constitutive promoter, or a tissue-specific promoter.

44. The composition of any one of claims 39-41, wherein the second of the two different vectors comprises a coding sequence that encodes a C-terminal portion of the hair cell target protein.

45. The composition of claim 44, wherein the C-terminal portion of the hair cell target protein is between 30 amino acids to about 390 amino acids in length.

46. The composition of claim 45, wherein the C-terminal portion of the hair cell target protein is between 30 amino acids to about 340 amino acids in length.

47. The composition of any one of claims 44-46, wherein the second vector further comprises a poly(dA) sequence.

48. A composition comprising two different nucleic acid vectors, wherein: a first nucleic acid vector of the two different nucleic acid vectors comprises a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors comprises a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; wherein each of the encoded portions is at least 30 amino acid residues in length, wherein the amino acid sequences of the encoded portions do not overlap, wherein no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

49. The composition of claim 48, wherein at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of a hair cell target genomic DNA, and lacks an intronic sequence between the neighboring exons.

50. A composition comprising: a first nucleic acid vector comprising a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, comprising a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; wherein each of the encoded portions is at least 30 amino acid residues in length, wherein the respective amino acid sequences of the encoded portions do not overlap with each other, wherein no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

51. The composition of claim 50, wherein at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of a hair cell target genomic DNA, and lacks an intronic sequence between the neighboring exons.

52. The composition of claim 50, wherein the first or second detectable marker gene is alkaline phosphatase.

53. The composition of claim 50 or 52, wherein the first and second detectable marker genes are the same.

54. A composition comprising: a first nucleic acid vector comprising a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, comprising a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; wherein each of the encoded portions is at least 30 amino acid residues in length, wherein the respective amino acid sequences of the encoded portions do not overlap with each other, wherein no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

55. The composition of claim 54, wherein at least one of the coding sequences comprises a nucleotide sequence spanning two neighboring exons of a hair cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons.

56. The composition of any one of claims 30-55, wherein the hair cell target gene is an OTOF gene, a TRIOBP gene, or a STRC gene.

57. A composition comprising a single adeno-associated virus (AAV) vector, wherein the single AAV vector that comprises a nucleic acid sequence that encodes a hair cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length hair cell target protein is generated at the locus of the hair cell target gene, and the primate expresses the hair cell target protein.

58. The composition of claim 57, wherein the hair cell target gene is a PJVK gene, an OTOF gene, a NDP gene, a CLRN1 gene, a TRIOBP gene, a STRC gene, a TMC1 gene, a VEGF gene or a HSPA1A gene.

59. The composition of any one of claims 1-58, further comprising a pharmaceutically acceptable excipient.

60. A kit comprising a composition of any one of claims 1-59.

61. A kit of claim 60, further comprising a pre-loaded syringe comprising the composition.

62. A method of correcting a supporting cell target gene defect in a supporting cell of an inner ear in a primate, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 1-29, wherein the administering repairs the supporting cell target gene defect in the supporting cell of the inner ear of the primate.

63. A method of increasing the expression level of a supporting cell target protein in a supporting cell of an inner ear of a primate, the method comprising administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 1-29, wherein the administering results in an increase in the expression level of the supporting cell target protein in the supporting cell of the inner ear of the primate.

64. The method of claim 63, wherein the primate has previously been determined to have a defective supporting cell target gene.

65. A method of treating non-syndromic sensorineural hearing loss in a primate identified as having a defective supporting cell target gene, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 1-29.

66. The method of claim 65, further comprising, prior to the administering step, determining that the primate has a defective supporting cell target gene.

67. A method of restoring hearing in a primate identified or diagnosed as having hearing loss, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 1-29.

68. The method of claim 67, further comprising, prior to the administering step, determining that the primate has a defective supporting cell target gene.

69. A method of restoring synapses and/or preserving spiral ganglion nerves in a primate identified or diagnosed as having an inner ear disorder, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 1-29.

70. The method of claim 69, further comprising, prior to the administering step, determining that the primate has a defective supporting cell target gene.

71. A method comprising administering to an inner ear of a primate a therapeutically effective amount of a composition of any one of claims 1-29.

72. The method of claim 71, wherein the primate has been previously identified as having a defective supporting cell target gene.

73. A method of correcting a hair cell target gene defect in a hair cell of an inner ear in a primate, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 30-59, wherein the administering repairs the hair cell target gene defect in the hair cell of the inner ear of the primate.

74. A method of increasing the expression level of a hair cell target protein in a hair cell of an inner ear of a primate, the method comprising administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 30-59, wherein the administering results in an increase in the expression level of the hair cell target protein in the hair cell of the inner ear of the primate.

75. The method of claim 74, wherein the primate has previously been determined to have a defective hair cell target gene.

76. A method of treating non-syndromic sensorineural hearing loss in a primate identified as having a defective hair cell target gene, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 30-59.

77. The method of claim 76, further comprising, prior to the administering step, determining that the primate has a defective hair cell target gene.

78. A method of restoring hearing in a primate identified or diagnosed as having hearing loss, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 30-59.

79. The method of claim 78, further comprising, prior to the administering step, determining that the primate has a defective hair cell target gene.

80. A method of restoring synapses and/or preserving spiral ganglion nerves in a primate identified or diagnosed as having an inner ear disorder, the method comprising: administering to the inner ear of the primate a therapeutically effective amount of a composition of any one of claims 30-59.

81. The method of claim 80, further comprising, prior to the administering step, determining that the primate has a defective hair cell target gene.

82. A method comprising administering to an inner ear of a primate a therapeutically effective amount of a composition of any one of claims 30-59.

83. The method of claim 82, wherein the primate has been previously identified as having a defective hair cell target gene.

84. The composition of any one of claim 1-26 or 30-56, wherein the second nucleic acid vector further comprises a destabilizing sequence.

85. The composition of claim 84, wherein the second nucleic acid vector further comprises a FKBP12 destabilizing sequence.

86. The composition of any one of claim 27-29 or 57-59, wherein the nucleic acid vector further comprises a destabilizing sequence.

87. The composition of claim 86, wherein the nucleic acid vector comprises a FKBP12 destabilizing sequence.

Description

BRIEF DESCRIPTION OF DRAWINGS

[0084] FIG. 1A is a representative image of Myo7a/Iba-1 immunofluorescent staining of cochlear tissue of a cynomolgus macaque (non-human primate) following administration of a single Anc80-GFP AAV vector directly into the inner ear through the round window.

[0085] FIG. 1B is a representative image of Anc80-GFP immunofluorescent staining of the same cochlear tissue of the cynomolgus macaque as in FIG. 1A.

[0086] FIG. 1C is a representative image of a merged immunofluorescent staining of Myo7a/Iba-1 and Anc80-GFP of the same cochlear tissue of the cynomolgus macaque as in FIG. 1A.

DETAILED DESCRIPTION

[0087] Provided herein are compositions that include at least two different nucleic acid vectors, where: each of the at least two different adeno-associated virus (AAV) vectors includes a coding sequence that encodes a different portion of a supporting cell target protein, each of the encoded portions being at least 30 amino acid residues in length, where the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length supporting cell target protein; at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of the supporting cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length supporting cell target protein.

[0088] Provided herein are compositions including two different nucleic acid vectors, where: a first nucleic acid vector of the two different nucleic acid vectors includes a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors includes a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the amino acid sequences of the encoded portions do not overlap, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

[0089] Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

[0090] Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

[0091] Provided herein are compositions including a single adeno-associated virus (AAV) vector, where the single AAV vector that includes a nucleic acid sequence that encodes a supporting cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length supporting cell target protein is generated at the locus of the supporting cell target gene, and the primate expresses the supporting cell target protein.

[0092] Provided herein are compositions that include at least two different nucleic acid vectors, where: each of the at least two different adeno-associated virus (AAV) vectors includes a coding sequence that encodes a different portion of a hair cell target protein, each of the encoded portions being at least 30 amino acid residues in length, where the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length hair cell target protein; at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of the hair cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length hair cell target protein.

[0093] Provided herein are compositions including two different nucleic acid vectors, where: a first nucleic acid vector of the two different nucleic acid vectors includes a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors includes a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the amino acid sequences of the encoded portions do not overlap, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

[0094] Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

[0095] Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

[0096] Also provided herein are compositions including a single adeno-associated virus (AAV) vector, where the single AAV vector that includes a nucleic acid sequence that encodes a hair cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length hair cell target protein is generated at the locus of the hair cell target gene, and the primate expresses the hair cell target protein.

[0097] Also provided are kits that include any of the compositions described herein. Also provided herein are methods that include introducing into a cochlea of a mammal a therapeutically effective amount of any of the compositions described herein.

[0098] Also provided are methods of correcting a supporting cell target gene defect in a supporting cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the supporting cell target gene defect in the supporting cell of the inner ear of the primate.

[0099] Also provided are methods of correcting a hair cell target gene defect in a hair cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the hair cell target gene defect in the hair cell of the inner ear of the primate.

[0100] Also provided herein are methods of increasing the expression level of a supporting cell target protein in a supporting cell of an inner ear of a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering results in an increase in the expression level of the supporting cell target protein in the supporting cell of the inner ear of the primate.

[0101] Also provided herein are methods of increasing the expression level of a hair cell target protein in a hair cell of an inner ear of a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering results in an increase in the expression level of the hair cell target protein in the hair cell of the inner ear of the primate.

[0102] Also provided herein are methods of treating hearing loss, e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, in a primate identified as having a defective supporting cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

[0103] Also provided herein are methods of treating hearing loss, e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, in a primate identified as having a defective hair cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

[0104] Also provided herein are methods of restoring hearing in a primate identified or diagnosed as having hearing loss that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

[0105] Also provided herein are methods of restoring synapses and/or preserving spiral ganglion nerves in a primate identified or diagnosed as having an inner ear disorder that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

[0106] Also provided herein are methods that include administering to an inner ear of a primate a therapeutically effective amount of any of the compositions described herein.

[0107] Additional non-limiting aspects of the compositions, kits, and methods are described herein and can be used in any combination without limitation.

Gap Junction Protein Beta 2 (GJB2)

[0108] The GJB2 gene encodes gap junction protein beta 2, a member of the gap junction protein family. Gap junction proteins are specialized proteins, also called connexins, involved in intracellular communication. Mutations in GJB2 have been associated with hearing loss and deafness (Amorini et al., Ann. Hum. Genet. 79(5):341-349, 2015; Qing et al., Genet. Test Mol. Biomarkers 19(1):52-58, 2015).

[0109] The human GJB2 gene is located on chromosome 13q12. It contains 2 exons encompassing ˜5 kilobases (kb) (NCBI Accession No. NG008358.1). The full-length wildtype GJB2 protein expressed from the human GJB2 gene is 226 amino acids in length.

[0110] Various mutations in the GJB2 gene have been associated with hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). For example, the c.35delG allele was found on 65.5% of patients from Eastern Sicily (Amorini et al., Ann. Hum. Genet. 79(5):341-349, 2015).

[0111] Additional exemplary mutations in a GJB2 gene detected in subjects having non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, and methods of sequencing a nucleic acid encoding GJB2 are described in, e.g., Snoeckx et al., Am. J. Hum. Genet 77: 945-957, 2005; Welch et al., Am. J. Med. Genet A 143: 1567-1573, 2007; and Zelante et al., Hum. Mol. Genet. 6:1605-1609, 1997. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

[0112] An exemplary human wildtype GJB2 protein is or includes the sequence of SEQ ID NO: 1. Non-limiting examples of nucleic acid encoding a wildtype GJB2 protein are or include SEQ ID NO: 2. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 2 can be codon-optimized to allow for optimal expression in a non-human mammal.

[0113] In some embodiments of any of the compositions described herein, the GJB2 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 1.

TABLE-US-00001 Human Full-length Wildtype GJB2 Protein (SEQ ID NO: 1) MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQAD FVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRH EKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAF MYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSG ICILLNVTELCYLLIRYCSGKSKKPV Human Wildtype GJB2 cDNA (SEQ ID NO: 2) atggattggggcacgctgcagacgatcctggggggtgtgaacaaacactc caccagcattggaaagatctggctcaccgtcctcttcatttttcgcatta tgatcctcgttgtggctgcaaaggaggtgtggggagatgagcaggccgac tttgtctgcaacaccctgcagccaggctgcaagaacgtgtgctacgatca ctacttccccatctcccacatccggctatgggccctgcagctgatcttcg tgtccacgccagcgctcctagtggccatgcacgtggcctaccggagacat gagaagaagaggaagttcatcaagggggagataaagagtgaatttaagga catcgaggagatcaaaacccagaaggtccgcatcgaaggctccctgtggt ggacctacacaagcagcatcttcttccgggtcatcttcgaagccgccttc atgtacgtcttctatgtcatgtacgacggcttctccatgcagcggctggt gaagtgcaacgcctggccttgtcccaacactgtggactgctttgtgtccc ggcccacggagaagactgtcttcacagtgttcatgattgcagtgtctgga atttgcatcctgctgaatgtcactgaattgtgttatttgctaattagata ttgttctgggaagtcaaaaaagccagtttaa

[0114] A non-limiting example of a human wildtype GJB2 genomic DNA sequence is SEQ ID NO: 3. The exons in SEQ ID NO: 3 are: nucleotide positions 1-156 (exon 1), and nucleotide positions 3336-5469 (exon 2). The intron is located between each of these exons in SEQ ID NO: 3, i.e., at nucleotide positions 157-3335 (intron 1).

TABLE-US-00002 Human Wildtype GJB2 Gene Sequence (NCBI Reference Sequence: NG_008358.1)  (SEQ ID NO: 3) 1 ggggtgcggt taaaaggcgc cacggcggga gacaggtgtt gcggccccgc agcgcccgcg 61 cgctcctctc cccgactcgg agcccctcgg cggcgcccgg cccaggaccc gcctaggagc 121 gcaggagccc cagcgcagag accccaacgc cgagaccccc gccccggccc cgccgcgctt 181 cctcccgacg caggtgagcc cgccggcccc ggactgcccg gccaggaacc tggcgcgggg 241 agggaccgcg agacccagag cggttgcccg gccgcgtggg tctcggggaa ccggggggct 301 ggaccaacac acgtccttgg gccggggggc gggggccgcc ttctggagcg ggcgtttctg 361 cggccgagct ccggagctgg aatggggcgg ccggggaagt ggacgcgatg gcaccgcccg 421 gggtgcgagt ggggccgggc gcgcgcggga ggggaaaaag gcgcgggcga gccgccagcg 481 cgaggtttgt ggtgtcgccg atgtcccttc ggggtactct agcgcagccg cctggctact 541 tgacccactg ccaccaaacg ttttaaattc accgaaagct tagcttcgaa gcaaagctcc 601 gtttcgccgg tgaagcagga agccttcgct gcaggaactg acctttacct cttggagcgg 661 cttctgcaga aaaatccccg ggcagagatt tgggcggagt ttgcctagaa ctaacgcgga 721 gccagccgat cccggcctac cccggggcca agatttcagt ggcttccctt tttcctaaac 781 acttcacgag ggtctgtttc cgggctgtgc tccccgccta gaaggaaaat ttttaggacc 841 cttgttcgcg aagaggtggt gtgcggctga gacccgcgtc ctcaggacgg ttccatcagt 901 gcctcgatcc tgccccactg gaggaggaag gcagcccgaa cagcgctcac ctaactaaca 961 gctgctgaga gctgggttcc gtggccatgc acctgggact gccttgagaa gcgtggtacg 1021 gccgtgtccc catgtgacct tagagtccct ttcgaaactg ctgtgcacag tcggtcacaa 1081 tttcagacac tggtgagaag ggtggaggaa ccctctgggg acagccaggc aaggtcgacc 1141 acccatcacc taagggtgga gaaatttaag gggtgaagag tcccttttgc cttttctgga 1201 tcctggtgat tcacctagtg tcttccctaa ggaactgaac caactcctcc gctggcctct 1261 ggcagccctc caggcggtgc aggatggcgt gggcccggta ggaagctgca tgtaaccgcc 1321 cagggtcggg aggccaggag ggcagctcct cctctgactt gaatattgaa aacaacttcg 1381 tcctgcttct gagcccctct taacccatga ccccctagcc cattggggag taaatcttaa 1441 tttactcctc ttcctgaaaa aggatcttta aaacaggtag cttcaactca agctttataa 1501 aataacaata tagggtttct cggaactgta tttttctcag ctgatggtaa ctggacaggt 1561 ctgtagaagg gtgtatgacc tgggtttggc aggtggaaga gggcaaagga taaacccctc 1621 ctcctgcagc cccatattct tggccaggtg tattgttgta aaccaggaga gagtttactt 1681 cggggagtat cctgttttcc actcagtgag ggccaatgaa gaatgtctaa ttccataaga 1741 tgcttttgtt aaaatcggaa tgttgctgtc ctcggtggtt ctgctgttgg gacgggactg 1801 gcctgagctg tgggtgctgt agcaggacaa ccagctcacc taagggcctc ccagtctgga 1861 ttatcaatgg gtcagtgctg aacctgggct aaaatattgt tttttccaat gatgttgtct 1921 ttcccaagct cagtgaagct aaatgtttca caggcctatg tcaatctgat gtaactttcg 1981 tggccacctc tctcctgtta gcctctgacc aaggtggcac tggatggttt ctgcctgacc 2041 ttggtgcccc gtggcagcga ctgtgggtca tgaaagacat tcactacgag cctgcttctg 2101 gagtccatca gaaaacggga tgcaacttgc ctaaaatgag gagaggagga tgcttttaag 2161 aaaaagaaga aggaggattc actaccagct ctgaagggtg gaaaagagat gattcatccg 2221 gattgtggag agggtggaat cttgtttagg agagcgttgg ttgtggcagg cagggtgtaa 2281 ctatgaatca gtgaagacaa ttcacatcct gggatgaaaa gaaggccatg ggctcacagg 2341 agattatcca ctggcctctc cacatccgct tgcagtaagg agtgtgggac tctcccaagc 2401 ttcagcgctg aactgcaatg cagtgacgtc gcttagctgg gccagtaacc gagggagttg 2461 aattttctgt cattttaaaa taatgtgtct tttaagaaac actttgaaat taaaaccaca 2521 gcccacaatt ataatgcact gttgcagcac ttatcaaaac agatatgcta actgagccat 2581 cagtgccagc ctgacagtga ggccaccaag ccatccacaa agcctacacg aaagtctgtg 2641 ctcacagtgg cttttctcca tgaagagggc attcctaacc tcttcctttc acgtaggagg 2701 aagcaaggtc ctttgtaaaa ttttaactcg gggtgcctca aatgtaaact taaccactgg 2761 taacaacagt ttcactgcta catgccacgt ctgtgaaaat tcattcaaga cattaaggaa 2821 agtggctcag cagagagact agacatctta tcctcacggt tctcctgtac ttggcctctc 2881 agcctttgag caaggttggc ccaagctagt atcggcccca gtggtacagc caaaacttga 2941 gactgcaaat ggatgcagct gttgaacgct gagtaacttc tgcagagtca ggaagaccca 3001 aggaagctct gcagaggatg caggggtacg gtcagaaccc ctgagtgcct ttcagctaac 3061 gaggacttta tgacactccc cagcacagca aatttttatg atgtgtttaa agattgggtg 3121 aattactcag gtgaacaagc tactttttat cagagaacac ctaaaaacac gttcaagagg 3181 gtttgggaac tatacattta atcctatgac aaactaagtt ggttctgtct tcacctgttt 3241 tggtgaggtt gtgtaagagt tggtgtttgc tcaggaagag atttaagcat gcttgcttac 3301 ccagactcag agaagtctcc ctgttctgtc ctagctagtg attcctgtgt tgtgtgcatt 3361 cgtcttttcc agagcaaacc gcccagagta gaagatggat tggggcacgc tgcagacgat 3421 cctggggggt gtgaacaaac actccaccag cattggaaag atctggctca ccgtcctctt 3481 catttttcgc attatgatcc tcgttgtggc tgcaaaggag gtgtggggag atgagcaggc 3541 cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac gtgtgctacg atcactactt 3601 ccccatctcc cacatccggc tatgggccct gcagctgatc ttcgtgtcca cgccagcgct 3661 cctagtggcc atgcacgtgg cctaccggag acatgagaag aagaggaagt tcatcaaggg 3721 ggagataaag agtgaattta aggacatcga ggagatcaaa acccagaagg tccgcatcga 3781 aggctccctg tggtggacct acacaagcag catcttcttc cgggtcatct tcgaagccgc 3841 cttcatgtac gtcttctatg tcatgtacga cggcttctcc atgcagcggc tggtgaagtg 3901 caacgcctgg ccttgtccca acactgtgga ctgctttgtg tcccggccca cggagaagac 3961 tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc atcctgctga atgtcactga 4021 attgtgttat ttgctaatta gatattgttc tgggaagtca aaaaagccag tttaacgcat 4081 tgcccagttg ttagattaag aaatagacag catgagaggg atgaggcaac ccgtgctcag 4141 ctgtcaaggc tcagtcgcta gcatttccca acacaaagat tctgacctta aatgcaacca 4201 tttgaaaccc ctgtaggcct caggtgaaac tccagatgcc acaatggagc tctgctcccc 4261 taaagcctca aaacaaaggc ctaattctat gcctgtctta attttctttc acttaagtta 4321 gttccactga gaccccaggc tgttaggggt tattggtgta aggtactttc atattttaaa 4381 cagaggatat cggcatttgt ttctttctct gaggacaaga gaaaaaagcc aggttccaca 4441 gaggacacag agaaggtttg ggtgtcctcc tggggttctt tttgccaact ttccccacgt 4501 taaaggtgaa cattggttct ttcatttgct ttggaagttt taatctctaa cagtggacaa 4561 agttaccagt gccttaaact ctgttacact ttttggaagt gaaaactttg tagtatgata 4621 ggttattttg atgtaaagat gttctggata ccattatatg ttccccctgt ttcagaggct 4681 cagattgtaa tatgtaaatg gtatgtcatt cgctactatg atttaatttg aaatatggtc 4741 ttttggttat gaatactttg cagcacagct gagaggctgt ctgttgtatt cattgtggtc 4801 atagcaccta acaacattgt agcctcaatc gagtgagaca gactagaagt tcctagtgat 4861 ggcttatgat agcaaatggc ctcatgtcaa atatttagat gtaattttgt gtaagaaata 4921 cagactggat gtaccaccaa ctactacctg taatgacagg cctgtccaac acatctccct 4981 tttccatgac tgtggtagcc agcatcggaa agaacgctga tttaaagagg tcgcttggga 5041 attttattga cacagtacca tttaatgggg aggacaaaat ggggcagggg agggagaagt 5101 ttctgtcgtt aaaaacagat ttggaaagac tggactctaa agtctgttga ttaaagatga 5161 gctttgtcta cttcaaaagt ttgtttgctt accccttcag cctccaattt tttaagtgaa 5221 aatatagcta ataacatgtg aaaagaatag aagctaaggt ttagataaat attgagcaga 5281 tctataggaa gattgaacct gaatattgcc attatgcttg acatggtttc caaaaaatgg 5341 tactccacat atttcagtga gggtaagtat tttcctgttg tcaagaatag cattgtaaaa 5401 gcattttgta ataataaaga atagctttaa tgatatgctt gtaactaaaa taattttgta 5461 atgtatcaaa tacatttaaa acattaaaat ataatctcta taataattta aaa

Solute Carrier Family 26 Member 4 (SLC26A4)

[0115] The SLC26A4 gene encodes the Pendred protein, and has homology to sulfate transporters. Mutations in SLC26A4 have been associated with hearing loss and deafness (Albert et al., Eur. J. Hum. Genet. 14:773-779, 2006; and Qing et al., Genet. Test Mol. Biomarkers 19(1):52-58, 2015).

[0116] The human SLC26A4 gene is located on chromosome 7q22. It contains 21 exons encompassing ˜57 kilobases (kb) (NCBI Accession No. NG_008489.1). The full-length wildtype SLC26A4 protein expressed from the human SLC26A4 gene is 780 amino acids in length.

[0117] Various mutations in the SLC26A4 gene have been associated with hearing loss. For example, point mutations V250A, D266N, E303Q, F345S, D697, K715N, and E737D have been reported in Chinese and U.S. patients with non-syndromic hearing loss (Dai et al., Physiol Genomics 38(3): 281-290, 2015).

[0118] Additional exemplary mutations in a SLC26A4 gene detected in subjects having non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, and methods of sequencing a nucleic acid encoding SLC26A4 are described in, e.g., Albert et al., Eur. J. Hum. Genet. 14: 773-779, 2006; and Qing et al., Genet. Test Mol. Biomarkers 19(1):52-58, 2015. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

[0119] An exemplary human wildtype SLC26A4 protein is or includes the sequence of SEQ ID NO: 4. Non-limiting examples of nucleic acid encoding a wildtype SLC26A4 protein are or include SEQ ID NO: 5 or 6. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 5 or 6 can be codon-optimized to allow for optimal expression in a non-human mammal.

[0120] In some embodiments of any of the compositions described herein, the SLC26A4 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 4.

TABLE-US-00003 Human Full-length Wildtype SLC26A4 Protein (SEQ ID NO: 4) MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPI LEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFP VVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVR YLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMA VKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGII SAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLG LLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKS TVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVD WNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFD DNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS Exemplary Human Wildtype SLC26A4 cDNA (SEQ ID NO: 5) atggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctacatggtgtcgcg gccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaagacgctgcggg agagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactcttgtgcccatc ttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcgggagttagtactgg gctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggatatggtctctact ctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttggaccttttcca gtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctcgtatccagcag caatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagtcctgattgcca gtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggattcatagtgagg tacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtctcacagctaaa gattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgctggttgagattt ttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcgtctgtatggca gttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagtaattgtgacgat aattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgttaaatccatcc caagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctgcatcattttcc atcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtatgattacaccat cgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctcttgttttgtg gccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttgctggcatcat ctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcagaagtcggtct tggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcgtctgtggaga cagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggctggatctcgg tttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttcttggaatggcc ttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaagaacctcaagga gtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaatgtatcaagtc cacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaatacagaaactaa taaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaataatgctttt gagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagagattcaagtgga ttggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtgcttgactgt ggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaattccaaagaat tgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcgggttctttg acgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacagaaccaagtg aaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaagatacccttga attaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacacttgcatcct ga Exemplary Human Wildtype SLC26A4 cDNA (SEQ ID NO: 6) ctcagccttcccggttcgggaaaggggaagaatgcaggaggggtaggatttctttcctgataggatcggtt gggaaagaccgcagcctgtgtgtgtctttcccttcgaccaaggtgtctgttgctccgtaaataaaacgtcc cactgccttctgagagcgctataaaggcagcggaagggtagtccgcggggcattccgggcggggcgcgagc agagacaggtcatggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctac atggtgtcgcggccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaa gacgctgcgggagagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactc ttgtgcccatcttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcggga gttagtactgggctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggata tggtctctactctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttg gaccttttccagtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctc gtatccagcagcaatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagt cctgattgccagtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggat tcatagtgaggtacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtc tcacagctaaagattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgct ggttgagatttttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcg tctgtatggcagttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagta attgtgacgataattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgt taaatccatcccaagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctg catcattttccatcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtat gattacaccatcgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctc ttgttttgtggccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttg ctggcatcatctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcag aagtcggtcttggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcg tctgtggagacagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggc tggatctcggtttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttct tggaatggccttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaaga acctcaaggagtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaat gtatcaagtccacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaata cagaaactaataaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaa taatgcttttgagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagaga ttcaagtggattggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtg cttgactgtggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaatt ccaaagaattgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcg ggttctttgacgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacag aaccaagtgaaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaaga tacccttgaattaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacac ttgcatcctgaaagtgggttcgggaggtctctatgagcaaggaatacaagacaaaacttcctcaatgcatt gactatttcttcagactcaaaacactcattcttttttctattaagccattgaaagagaagcactaagactg cttctaggctttatttataaaataaacaccttatccctaacatgggcaaaatggctagaattattcagacg atttggcagcgtccagggtaagctggtgttataatacgctgctgatctacatcacagatttgctaataatg ttcacgtgggccctggcatatctctgttcagttagagtgagtgctgacccaacagcctctgtggtcaagcg agtcacgaatgattaatcataaagaaaaatcagtttttgactgacctggatatccatgagctgcactgatc accatgtaaggtcacatttagtaaatgctgaaataaaatgattaatgcatttatcaataaaagcctttgaa aatactttggataataaattggagttttaaaaatgcaaatttgcttagtatctaataatgaagtgttatta catatagccggaattgaggatctctttgatcctggaaatggtttacctaaaagctacagaaccaggccaat atattttgaaatattgatgcagacaaatgaaataataaagagattttcatggtttataaaaatcttttttg atatgataataatcatgatcacaactgagatcaaaaaaatatatgacagattattttgtttaaaaatgcag ttttaattatcttagtctatagaaatgatcattgcatggaggcatgtataggtatgatctgtgtaaaatct gacataaaaacagtgctattctgagtgaaaatttttttgatgtgcttacataaccatggtgattaaaatga gtttatattttttctcaaaaattttagcagtgtgtaaagtaagtaatctttaactgaactctgaccactta aaaaaaaatctaaaaattgaactacctatagtagtctgtgtttaaagtgaatttttaaagacaaagcattc taaatgaactcaatataaaaacattcatttggaatgtacatactgaaaaatacaggtttttttgaccaaaa gtttttatatcttttctttttatttatttttttcctaagtgccaacaattttctagatattatatacaaca caggctttgatcttggggacttttcccatatatttcacactggagtgaatgaagttgtacttcatttctag agaaaagttatacccaggtccccaattgagaatgtcttgcttgattgaaaacgacatcatcccttggtata ctccagggattggtttcaggacccctgcatttaccaaaatttgtgcacactcaagtcctgcagtcacccct gcctaaagatagaatggcttctctgtttttcttctgaaatacaaccagaaacaatgtgtctatttctgaaa gaataggattaatgatcatacaaatgggttaatcctgaattctggttgtaaatctggttacagcataacta ggattataatgctgcctcattttcacagcactacttgcttatattgacaacaaatcatctcgctaaagagt gaatgtaggccaggcgcggtggctcatgcctgtaatcccagcactttgggaggccgaggcgggtggatcac gaggtcaggagatcgagaccatcctggctaacatggtaaaaccccgtctctactaaaaatagaaaaaaaga aattagcctagcgtggtggctggcgggcgcctgtagtcccagctatttgggaggctaaggcaggagaatgg cgtgaacccgggaggcggagcttgcagtgagccgaggtcgtgccactgcactccagcctgggcgacagagc aagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaagagtgaatgtaatagtcttgcagaaaatgaatg aatacctttgttcaataaaggaaatatgcactgctcacttttttgaaggaaatgccaaagttacgttttac aacaaggctagagtttgtaaattctgggttcatttgtgatgacataagtcagcaaactgcgggaatactgt ctcttctatgtattttgtgaatagtaagcataattttagttttgtattatcaatgaaaatttcacttgaaa ttaaagctgccttttgttatatttttaacctataggataagattccagtattgtatatgagttttaacaaa ttaaaaaatcaaatcatgtacatttgaaaatatttgcacacatttaaaaataaatgtaaagttgtctttta aactactcggatgtgtcctttctgaacaa

[0121] A non-limiting example of a human wildtype SLC26A4 genomic is SEQ ID NO: 7. The exons in SEQ ID NO: 7 are: nucleotide positions 1-221 (exon 1), nucleotide positions 1005-1171 (exon 2), nucleotide positions 2262-2801 (exon 3), nucleotide positions 11504-11614 (exon 4), nucleotide positions 13530-13714 (exon 5), nucleotide positions 14311-14475 (exon 6), nucleotide positions 22568-22720 (exon 7), nucleotide positions 22821-22903 (exon 8), nucleotide positions 28419-28566 (exon 9), nucleotide positions 29490-29603 (exon 10), nucleotide positions 33769-33846 (exon 11), nucleotide positions 33987-34082 (exon 12), nucleotide positions 35299-35405 (exon 13), nucleotide positions 37408-37477 (exon 14), nucleotide positions 39449-39541 (exon 15), nucleotide positions 40467-40562 (exon 16), nucleotide positions 41193-41423 (exon 17), nucleotide positions 43697-43751 (exon 18), nucleotide positions 49420-49565 (exon 19), nucleotide positions 51905-51988 (exon 20) and nucleotide positions 56348-57175 (exon 21). The introns are located between each of these exons in SEQ ID NO: 7, i.e., at nucleotide positions 222-1004 (intron 1), nucleotide positions 1172-2261 (intron 2), nucleotide positions 2802-11503 (intron 3), nucleotide positions 11615-13529 (intron 4), nucleotide positions 13715-14310 (intron 5), nucleotide positions 14476-22567 (intron 6), nucleotide positions 22721-22820 (intron 7), nucleotide positions 22904-28418 (intron 8), nucleotide positions 28567-29489 (intron 9), nucleotide positions 29604-33768 (intron 10), nucleotide positions 33847-33986 (intron 11), nucleotide positions 34083-35298 (intron 12), nucleotide positions 35406-37407 (intron 13), nucleotide positions 37478-39448 (intron 14), nucleotide positions 39542-40466 (intron 15), nucleotide positions 40563-41192 (intron 16), nucleotide positions 41424-43696 (intron 17), nucleotide positions 43752-49419 (intron 18), nucleotide positions 49566-51904 (intron 19), and nucleotide positions 51989-56347 (intron 20).

TABLE-US-00004 Human Wildtype SLC26A4 Gene Sequence (NCBI Reference Sequence: NG_008489.1) (SEQ ID NO: 7) 1 ctcagccttc ccggttcggg aaaggggaag aatgcaggag gggtaggatt tctttcctga 61 taggatcggt tgggaaagac cgcagcctgt gtgtgtcttt cccttcgacc aaggtgtctg 121 ttgctccgta aataaaacgt cccactgcct tctgagagcg ctataaaggc agcggaaggg 181 tagtccgcgg ggcattccgg gcggggcgcg agcagagaca ggtgagttcg ccctgaagat 241 gcccacaccg cccggcccgg gctccactcc cggggaggcc tcgagggttg cggatgggac 301 tcttaagtgg tcacggatca ggtgggcagg gggcagtaca gctttctttc tgagacgccg 361 agagcgaaca ggctgctcgg aaaacaggac gaggggagag acttgctcaa taagctgaaa 421 gttctgcccc cgagagggct gcgacagctg ctggaatgtg cctgcagcgt ccgcctcttg 481 gggacccgcg gagcgcgccc tgacggttcc acgcctggcc cgggggtctg cacctctcct 541 ccagtgcgca cctggagctg cgtcccgggt caggtgcggg gagggaggga atctcagtgt 601 ccccttccag ccttgcaagc gcctttggcc cctgccccag cccctcggtt tgggggagat 661 ttcagaacgc ggacagcgcc ctggctgcgg gccatagggg actgggtgga actcgggaag 721 cccccagagc aggggcttac tcgcttcaag tttggggaac cccgggcagc gggtgcaggc 781 cacgagaccc gaaggttctc aggtgccccc ctgcaggctg gccgtgcgcg ccgtggggcg 841 cttgtcgcga gcgccgaggg ctgcaggacg cggaccagac tcgcggtgca ggggggcctg 901 gctgcagcta acaggtgatc ccgttctttc tgttcctcgc tcttcccctc cgatcgtcct 961 cgcttaccgc gtgtcctccc tcctcgctgt cctctggctc gcaggtcatg gcagcgccag 1021 gcggcaggtc ggagccgccg cagctccccg agtacagctg cagctacatg gtgtcgcggc 1081 cggtctacag cgagctcgct ttccagcaac agcacgagcg gcgcctgcag gagcgcaaga 1141 cgctgcggga gagcctggcc aagtgctgca ggtagcggcc gcgcgggcct gcgtagagag 1201 aagcggagcg gggcgtccac gccttgggga gggaagggcg tccccagcgg gcgagagtgg 1261 ggtgcgggcg gcggagcccc tgggcgccag ctgcttctcc cagaggcccg actttcggtc 1321 tccggtcctc cacgccgccc ttctggtggg agggtggctc catcagtctc gggcccgaaa 1381 tgaacttacc tgggaaactc gcctttgggg agagtgggtt ctaggagccc cgtctctctt 1441 tttcctctct gaaggaaact tggagtgcct cttggggtac agtgggtccc tgttgccttc 1501 ttgggagctt gtttaaatga aatgaatagg gaaacccagc tcttgaccag gaggagtcct 1561 tgaaacactc aagctaagta ggcgggctac cattcagtta gagaccagga tgcaagctag 1621 aacccagggg agcgcggggt gtgccaagta cttcatcagc aggctgtggg acccctgggg 1681 aaagccaccc tcagtctcta aacccaaaca tgccgtaact agatgtcaca aacataaaga 1741 aattagagtt tctaaaacct ttcattatag aacatttcaa atatatgcat aagtagacgt 1801 agtagtataa tgaactcccc acccccaccg tttttaaccc atcactcggc ctcaactgtg 1861 atcaaatcca agttactctt gtttcttgta tctacaccta cttgctccct ccagtattat 1921 ttttaagcaa atctcatata gcatactgtc tttatgtatt ttactgcata tctttaaaga 1981 ctcttaaaaa atataaccac atttcatgat cacaccttaa tatctaaaaa taacctccta 2041 atatcaaaaa ttgagtcatt attaaaatgt ccaatcgtcc cataaatgcc ttaattaaaa 2101 aacaatttat tcaaatcagg agttatacca cctacttttg atatttttct ttcatctgta 2161 ggtcactgaa tttaaaaact accaagtagc aaggtataag gtatacattc ctcatgctaa 2221 gatttttgta aaaactagct ccaggcttgt attgccaaaa tatactcagt gtgtttatct 2281 tctttaaaga aaataataat aataaggcgc ctggattagg agtctgaaaa gtaatctcca 2341 tttagagact ccacatccat cagtctctgg ctggaccaga aaataggttt ttgtgtagga 2401 atattttttc agaggattaa aaatgtgagc gaggggtggg acacttaatc ctgtgttctc 2461 tagaagagtg catttaaaag gatagataca gttcttggca aaagcatggt aagcacttca 2521 gggttattat tttccaggaa atacttatcc tttttccaaa tagttataaa catcagcaga 2581 atccagttca taactttgtg atttgcaaat tggttgtgac tgagattgga ttgaaaaccc 2641 agttttcttg ctttttgaca gttgttcaag aaagagagcc tttggtgtgc taaagactct 2701 tgtgcccatc ttggagtggc tccccaaata ccgagtcaag gaatggctgc ttagtgacgt 2761 catttcggga gttagtactg ggctagtggc cacgctgcaa ggtaagatgt tggcagattg 2821 agagttctgg tctccagcag gagtttaaca cttctcccca gctaccatag gtctgtgaca 2881 gatggttgct tacccttcaa ggcctgtatc tttcctgtag agccccttag tggagagagt 2941 cacctctctt ctccccttcc ttagagttct cttcctggga aactgctgcc ccactaggtg 3001 cagaggtcca atttagaggc atatactagg cagtggcttc tcaatttttt taaattttat 3061 tttatttgag acgggggctc gctctgtcac ctaggctgga gtgcagtggc gcaatcctgg 3121 ctcactgcaa gctccgtctc ccgggttcac gccattctcc cgcctcagcc tccccagtag 3181 ctgggactac aggcgcccgc cactacgccc ggctaatttt ttgtattttt agtagagacg 3241 gggtttcacc gggttagcca ggatggtatc gacctcctga cctcgtgatc cgcctgcctt 3301 ggcctcccaa aatgctggga ttacaggcgt gagccactgc acccagccag cttctctatt 3361 ttcattgacc acaattcaat aagaaatgtg taaagagttt caagtcaaga tttaaaaaaa 3421 aaaaagaaat gtgttacatc ctgatatata catatatatc taaagttcct gtgaaatatt 3481 tattataaca atgtgctaat ctttcacttt gttctattat gcttaggttt tttaaatgat 3541 gattgcagca cattaaatta ttttatatcc acacgtggat cttttttgtt ggtttgtttt 3601 gctttgcttt ttagagatac agtcttgctc tgtcacccag gctggtgtgc agtggcacga 3661 tcttggctca atgcaacctc tctgcctctc gggttcaagt gattcttgtg cctcagcctt 3721 ctgagtagct ggggctacag gcatgtgcca ccatgtccag ctaattactg tatttttagt 3781 agagatgggg tttcgccatg ttggccaggg tggtctggaa ctcctaacct caagtgatcc 3841 gccctccttg gtatcccaaa gtactgtgat tacaggcatg agccaccatg cccagcctcc 3901 cacacgtgga tcttgaggtg tagtttgaaa ctggcttaag gaaaagtgaa gggagcttcc 3961 tagcctggac tccacatgaa tgttttgcct gcccctcatc cctttttaaa aaaattcatc 4021 ctcttatttt aatgtgtggg aaaatgtgcc aacataggtg gttatttgtt cttttataaa 4081 ctgagttcat accataatat tcccataagc atcttagaaa tctgttgtat agttggtgcc 4141 tagcagcatg gcattctcct ctgtccccta tccccaccat ctcgtttctg ccccaccccc 4201 aacaccctga ccaatttccc aaagaccctg aatcatgaaa acagaaatat cgttatttat 4261 tataatttgt gaaacaccta atatgttcca ggcactaggt atgctgacac gaataagatg 4321 catcctctgc ttccaaggaa ctcatagtcc aatggagaaa gagaaaacaa ttcaatgtga 4381 taagggctgt ggcaggggag tgcaaattac ttgctaaggg agtgcaaatg aggttcactc 4441 aaagcggtct taggggatct tgaatagctt cctggaagtt gaatgtcaaa gctgagtttc 4501 cctgatggct aagtctgagt ttgccaagtg atgggaagta gggtggggtg gggatggctt 4561 gaaaatagac tatttcagaa gctagtaatg aatgttgagc aatattgtga gctaaaattt 4621 ggctatggag ctttcaagat tgctcagatc aggccaggta gatgcccgaa gagaaggagg 4681 atggcctatg aacccagggt ggagcctcag cctgatcaag catgttctta atcacaaagg 4741 tggacgggag agagactagg atgggcbgtg tggttcctaa gttaaacaat gccaagtatt 4801 ctacactgtg ctctaagggc tgtgacatgg tgacaccctg tgactcctgg gggacaggaa 4861 ccatgcctca ttcatgtttg ttcagcaggt gcctagcaca gagacaggca cataatagat 4921 ggtatattta gtgaaaaaga ttgaattgca ttcctgataa tgaatcttct ttatatataa 4981 aaaatggtgg ttcatgctcc atgtctcccc agttttcata gacaagtatc ttataagaat 5041 tcattttgtt tataagcatg agacactatg ctaagtaaga atgttgccag ctatctcatt 5101 taatcctcat aacaatcctg ctaggtaggt ctattattat ttcattttca gtaggtgaaa 5161 aaatctatta aatcttgccc agggtcacgt ggctggtaag tggtacagct gggattttaa 5221 tccggtgtct attgtgtagt tccttacttt atgggtaaga tgcttttcta gaaacattat 5281 ctctataaag ttttctgtgt aaggtgaatt tctgggaggt taatctggct cagttacaca 5341 tccatttatc attcattcac ttaataaata tttataaact aattctgtag accaggtatc 5401 cagccatgtg cactcagtgg ttcattaaca ggcacaggtg ctgacttcat ggagctttgt 5461 aaaattattt tgaggggtag ggatgggaat taaataagta gataaataga aaaataatta 5521 tagattgcaa tatctattgt ggtggattaa atatactgca atagggatta atttgaaagg 5581 tggatcttta tttttatatt tttttgagac agggtcttgc tctgttgcgc aggctggagt 5641 gcagtggtga gatcacagct caccacagcc ttggcctcct gggcccaggt gatcctccca 5701 tctcagcctc gccagtagct ggaactacag gcatgtgcca ccatgcttgg ctaatttttg 5761 tattttttgt agagacaagg tttcaccatg ttgcccaggc tggtctggaa ctcctaggct 5821 caagttatct gcctgcctcg gcctcccaaa gtgctgggat tagaggtgtg agccattgtg 5881 cccagccagg aagggaggtc tattttagat ataatggtca aggaagaact tactgagaag 5941 gtgaaattta gtaaaagaca agagaatgag aaggagacag ccatgtgata agcagaaaaa 6001 aagagtgtac caggtaaagg tgcaaaggcc ctgaggccag aaaacttagc attttccagg 6061 gaggaagagg aagaattgta gtgtggatga gtgcagtggg ggagggtgag taaaccatga 6121 aataaactga ggcaggactg ggattaggat gaggtaaggg aggcactcac tctcaggatg 6181 cctctttaaa tattgtaccc taggaaactc atttgcctca ccctattcct ggccctgtgg 6241 ggatattgct gtgaattaaa gggagaatgg gtgtgtcagc ttgaaccaga tgatgcaggc 6301 tatgaagaga gctgcaagat aggaatatat tgtgcagcaa gaatcactga cacataatga 6361 tgagtgtgga tgaaaatcac tgatgcctcc aaggttgttg gcttgagcaa ccggatagat 6421 cattacatca tttatctaaa tggcaaagac aggctgagga gcaggtttgg gataggaaat 6481 caagtttcct tttggatatg ctaagtttga gacacagggt gagacatcta agtggagatg 6541 ccacctagag aagtgggagc tactgcaagt gtgaaggtta gaggagaggt ctaggctaga 6601 cataaaaatc aggaaagcat tgctgaagag gtgatattta caagagtggg aatgcctgtg 6661 attacctagg aagaaagggc aggtgtagaa gaaaagagag ccagagtact tagaagttag 6721 gaaggcaagg agaggggcag ccaagaacct gagaaagcct ggcgcaggaa gttgaagaca 6781 aagaacaacc aaaggaatgt gggatcagaa gccaagagag aaggtttaaa aaaaaaaaaa 6841 aaaaaaaaaa agcatagagg ggctgagagt gttgaatttg cctgaggggt ggggtatgat 6901 gaaggattac agactgcttt taagaagttt tgccatgaat cagagggaga taagagatga 6961 agacagagtg aagggagaat ttgtttttct taatatggga gatactagaa cgtatttgtg 7021 aaccgatagg aatgacctag tagaaagaaa gagatctgtg gtgcaagaag tacaagagaa 7081 ataactagaa gcaaagtagt aaaaaggggc aaacgtggag gggtttgaga atggaactag 7141 gagaactact ccttaaaggc aggagggata tttcttccat tttcaaagga agatagccca 7201 aatggtgcag atgcagacgg gtttgaaatt ttgatgaaaa gtaacttggg agcatctcat 7261 gcattctgtg ttttcgatta aatgcagaat atgtccctta actttgagtc tggtggagaa 7321 gggtttgggc agattgaggt aagtagggga ggtttgaata gttgtctcaa ggagaggaaa 7381 ggcacacccc ctgaggaaat gtaactgggt ccccaggcag tgttgagtgc ccatctagca 7441 cttgtggtca cacattttac atgaaattgg ttagcccaga tgtagatgcc ttcagtccag 7501 tttatctagc tgctcaaagg ctctcatgga taaggtagat gtttgaggtc agccaaattg 7561 gggttttgcc agacaagaaa aggaaggaaa gagagagtga aaaaagggag ttaagaatat 7621 ttgcaaaatt ccatggaatc tgtgtgggca agggtggaag tgaagacagg aaggtgtgga 7681 ggatagagag aaagtggatc ggttaattaa ttagaagcct cgtgagcaca aataaatgtt 7741 gcaataagga ttctgcagta gatgagctgg aaggtttgga ggctgtagct ggagagaggc 7801 tcaaaattca gattttggag gtggtggtgt ggtttccagt gatgacaatg tccatgccac 7861 aaccactggc tgagcagctg agtagtagaa caactccgag aagaccagct caggttactg 7921 ggaagccagg aagttgctaa ggatgatggg atctttgtga tttttgttat taaaacaaat 7981 tcccatcaga cagcaaaaga tcgatgcaac ccttgtagtg ctatttttat tcacaacttt 8041 aaggagtctg ctgtctgctt tctccttttg acttttatgt atttgtttgt ttaaacaaca 8101 gaaatttatt tctgcaacat gaaggtgcct gtagattcag tttctggtga cagcccgtca 8161 ccttgctgcg tcctcacatg gtggaaggct ttacctttag aagaaattta aatttaatat 8221 aaatttcaac tgtttattag cacctgcttt gccagtattt gtcaccatgc tataaatcat 8281 gactaccaac agagaaattc tatcatttaa atcaatggct cagatttctt ctaatttttt 8341 ttcttttttg agactctttc tcacacaggc tggagtgtag tggtatgacc ttggctcact 8401 gcaaccactg cctcctgggt tcaaactatc cttgtgcctc agcctcctca gtagctgaaa 8461 ttacaggcat gtaccaacac ccccagctaa tttgtgtatt tttagtagag acgagatttc 8521 accatgttgg ccgggctggt cttgaactcc tggcctcagt gatcttccca cctcagcctc 8581 ccgaaatgct aggattacaa tcatgagcca tcacacctag ccccagattt ctttacaaat 8641 tgtgtaattt taaaactgtt gtaccaagtt tctttataat aaagatgatt ccagtatatt 8701 tgagtagtag tggtccctaa atgggacact ctgtatgaaa actgaaaagt tccccttttc 8761 caggcatatt aagaactgca gagcccagtt tggggaaatg gaagtttgag aaggacttga 8821 aaaatgtcca tatgaaatag acaagttgtg ctttcatccc ctgctccttc ttttcttatc 8881 ttccttctgt ggagtcacct tcctatttta ttccatgctg ttgggactac tgactattgc 8941 aattcctgtt tgtaatttac atattaaaac aattgtacta atagatatat ttttctagaa 9001 tacaaactcc actagggcag agactttgtt ttaacagtgc ctgacacatg gtaggtgcat 9061 aatcaactgt tgttgaatga atgaatgctt attgtagaaa actagaaaat acatataagg 9121 aacatgaaaa aatacctcca ctacaaacta gaagtctcct ctgatcctac catacagata 9181 acccattgat atttcagtaa atatcttact aggcacataa atacttatct atataaaagt 9241 ataatgaaat gtctggaaat aataagcacc aaattcagga taattgttgc cttctgaggg 9301 tagagggagg aaagaggatg tgattgagga agagtatact gagagtttcc gctgcattgg 9361 cagtaattta tttcttaagc tagatgatgg atacatgaaa gtttattata ttattcattg 9421 tgtattgtgt ttcttgtata tgtaaattac ttcatatttt attcaaaata cctccagatt 9481 tttttttttt tttgagatgg agtcttgctc tgttgcccag gctggaatgc agtggcgcaa 9541 tctcggctca ctgaaacctc cgcctcctgg gttcaagcag ttctctgcct cagcctcctg 9601 agtagcbggg attacaggtg cctaccccca tgcctggcta atttttgtat ttttagtaga 9661 gacggggttt caccatcttg gccagggtgg tcttgagctc ctgacctcct gatccaccca 9721 cttcggcctc ccaaagtgct gggattacag gtgtgactca ccgcgcccgg tccctccggc 9781 tttttttaat gcgtacactc ccacaggctg gagtgggagt gtatttttta caaaagagga 9841 agcatacata cctatcagtt ttgaatcttg attttactca cttttttccc tcttacttca 9901 catctctcca cgttactgaa tgtacttctg agcatcacat caatttcatt tcatagaatt 9961 acgaagtatg aagcataact tagttaacca cttccctgct tggggacatt catctgataa 10021 gtaatattga gtgtgtgggg gccagcatat tcaggcbgtt gccattttta ataaactact 10081 ataaatgtaa ttccttatta atgactcaag agtgaaaagg cttgattttc tctcattgtg 10141 agtgagtgaa gggtgaggag gtaaaacgga gtaagatatg ctggctacct aagtatttaa 10201 ccaaggaaaa gaatgtcatt atcctcttct aaccctcatg taaactagaa tgttgatttc 10261 tctatagcca ggcattaatg ggtctggggg ctgctgccat tgcctagtgg aggagttggt 10321 caacttcatc agggtagagt tgtcttgtct gctgctgagt ataattatca tattttttct 10381 ttgggtctaa cttttcttcc ccaccaaaaa aggagaaagg gcagtgtaac aatgactgtg 10441 tccctcagaa cgcagagaaa tattgagctc agacacaact gcctctgtgc aaaactggtc 10501 tgagcctttg gagtgaattg accaaaactt ttttttttct tttttagaca taaggtcttg 10561 ctctgttgcc caggctggag tgcagtggca cgatcatagc ttgctgtaac ctcaaactcc 10621 tgggctcaaa caatcctcct gcctcagcct ccttaataac taggactaca ggcgtgaacc 10681 aatatgctgg gctcattcat tttattgtag agatggagtc ttgctatgtt ttccaggctg 10741 gtctcaaact cctgggctca actgatactc ctgcctatgg cttcccaaag cactgggatt 10801 ataggtgtag gacaccaggc ctgaccaagt ttttaatcaa catttgactt gattgttttt 10861 tcccactgat ctgattggtg gaagactgaa ttactgatca actgagtcca ttcatttgag 10921 caggtgatgt ttgtagatgc aatcattgtt ccaggtgatt tggatcctgt tctgcatcct 10981 agcatagcca gtctgtatgc aagataagga gaccaactca ggacaggctg atctgttgaa 11041 actgtaaatt gagagtatct gtgtaaaggc ccttctttct gcagtagaaa gacagatgct 11101 cctctacttc tcatgagtta catcctaata acccattgca agttgaacat attttaagtc 11161 aaaaatgcac ttaatacacc taacctatgg aacatcatcg cttaggctat cctacctgaa 11221 atgtgctcag aacacttaca ataacctaca gttgggcaaa ataatctaac gcaagcctat 11281 tttataataa agtattgaat atctcatgta gtttactgaa taatgtactg aaagtgaaaa 11341 acagaatggt tgtatggtta cttaaagtat ggtttctact gaatgcatat tgcttttgca 11401 tcatcataaa ggcaaagtca taagtggaac cattgtaagt tgaggacttt ctgcatactg 11461 taactttggt ttgtgaatgt aatcactttg catgtgcttt cagggatggc atatgcccta 11521 ctagctgcag ttcctgtcgg atatggtctc tactctgctt ttttccctat cctgacatac 11581 tttatctttg gaacatcaag acatatctca gttggtaatt ataagtatat tttacaatta 11641 tatttgctca tgtttaaagt gttttggcta tattaagtgc attatacctc tattaggttg 11701 gtgcaaaagt aattgcggtt ttcacaatta tacttttaat tgtgaaaacc gcaattactt 11761 ttgcaccaac ctaatatatc tgtgttaatg ttgtcaggga aatgggattt cagtgttttg 11821 cctgcttttt ctattcactg atgttaggta acttttttaa tgaagtggaa aaataaaaaa 11881 actgaaaatg acagcctact ttaacatttt agcatgtttt gctttttaaa aacgtgatca 11941 atttgactcc atttttggag tcataatgac agggaaaaaa tgacacaagg tctttgaacc 12001 taccatttta ctggattaac ttagaaatta ctaagtatgt tcatcaaata catgttcatg 12061 atttaattaa agagcatact tattttaaat cactaatatt agaagactgg caaaatctta 12121 ccaaaacaat ttagaagcta agcttggctt tctttcttgg tatggcttat aataagtttt 12181 cctgctattc ctaaaatttg aattctcgtt tgttagaatg tcctagtaaa tgagtgtttt 12241 aatgctattt tgtgactttg acatttatac tagagaaaat tttgctccta catccatctg 12301 ctggctagac atgtctacct cgatgatcct cttgaaataa atgcaaccat ctactttatc 12361 cccaacccat gtttttgtcc ttagttgtat ttccttagaa ggagatcaga aagaggtttt 12421 gattgaaaga acttccacac cttggagaat caatcagtgt tgagtgcttg actagatgag 12481 gaacatggaa gcbggttttt ctctttggta ttctatacat tgagatattc caggtgactg 12541 gggttgggtt ttgagacctc aaaaccataa agccttccat gatgagaggg tagaatcatc 12601 atcatcgtca tggataaaaa taacagtagt gaacggagca attgctgaaa aaaaaatatt 12661 ttttaaaata taaaatctta cagattgaca tttgatatga aaaaatgttt tgtcttacaa 12721 aaagagaaag aaacttcata ctccctttgc tgttttttta atcctaactt cgaccctgtg 12781 atattgatca aggtactcag atccacagag atcaggacat tggacactct aggaaattaa 12841 tgagattata tgaaataaaa gttgagcgga acaagtaaac actcaatgta tgtgctacct 12901 ttgccagaaa acctttcctg acaactctca tccctgtccc caccacccat acacatgagg 12961 atcacacaca gacaggttag acgacctttt gatatactca cgaagcatcc tgaatgttgt 13021 attctaataa ctacctacgt gtctctctcg cctatttcta ggtcatgaat gcctcgagat 13081 atctgcgttt ttagcttctt tttgttgttg ttgagacaga atctggctct gtcacctagg 13141 ctggagtgcg gtggcgtgat ctcagctcac tgcagcctcc acctccccag ctcaagcaat 13201 ccccccacct cagcctcccg agtagcbggg accataggca cgcaccacca cacccagcta 13261 atttttgtct tattttggta gagatggggt tttactatgt tgcttaggct ggtctggaac 13321 tcctgggctc aagcgatctt cccacctcag tctcccaaag tgctgcggtt acagatgtga 13381 gccactgggt ccggctcagc ttctttcgtg aacaaacaat attttcctag tcacagctaa 13441 atcttttata cattttttaa accctatgca gacacattga acatttgtga ttaataactg 13501 attaattgtt agagactttt tttccccagg accttttcca gtggtgagtt taatggtggg 13561 atctgttgtt ctgagcatgg cccccgacga acactttctc gtatccagca gcaatggaac 13621 tgtattaaat actactatga tagacactgc agctagagat acagctagag tcctgattgc 13681 cagtgccctg actctgctgg ttggaattat acaggtaatg aacttacaag taaaatatag 13741 atggatgtaa tttttatttg aaattaactt taaagcatat agacttaaag attctactaa 13801 aaacaaaaca aagtaatttc ctggaaccca aaattatttt ctaaattacg ttgttttagg 13861 tcaggtgcta aaatagtaag caagacccca cttattaagg ctcacttatc atcaaagtca 13921 gagacagaaa aaagcacaga agaacatgtg tgattcaatt gaggatgaga gaagggaaat 13981 atacgggaat ccataaagga gaaaaagtgt tctggtgagc ggagacacag gaccgaaagc 14041 cacataaata agctctgggt ttttgctttt ctaagtacat gtatagaaat acttcaaggt 14101 ttttattaca cttagttttc aaattttaga gtggtggagg aaggggagtg atagggtatt 14161 aagaaattca tatttttttc taccagtatt tttgtgctat aggcaggcta ctagtgtttt 14221 cattggtatt aagcttgatg taatatttcc agagagtagg tttctatctc aggcaaacat 14281 ttaatttttc tttccttttc cttatcgtag ttgatatttg gtggcttgca gattggattc 14341 atagtgaggt acttggcaga tcctttggtt ggtggcttca caacagctgc tgccttccaa 14401 gtgcbggtct cacagctaaa gattgtcctc aatgtttcaa ccaaaaacta caatggagtt 14461 ctctctatta tctatgtaag tgttgcttct tgctccaggg atgggtcact gttcattcca 14521 gaaacaattg tattcattct ctgagtctgg gccaggcgtg gtggctcaca cctgtaatcc 14581 cagcactttg gaaggccgag gtgggcagat tgcttgagcc caggagtttg agacgtgaga 14641 cctcatctct taaaaaaaaa aaaaaaaaaa aagaaagaaa gaaaagaaaa gaaaaagaaa 14701 gaaaaaatcc aaaaatccga aaatttgctg ggtgtggtgg tgcacacttg tagtctcagc 14761 tacttgggag gctgaggtgg gaagatctcc tgagccctgg aggttgaggc tgcagtgagc 14821 tgtgatcgcc ccactgcact ccaccctggg tgacagagca agaacctgtt tcaagcaaaa 14881 acaaaatcaa aacaaaacaa aacttgagtc tgggagcacc cacatttctt tctttctttc 14941 tttttttttt tttttttgag acagagtctt actctgtcac ccaggctgga gtgcagtggc 15001 atgatattgg ctcaccacaa cctccacctc ccgggttcaa gcgattctcc tgcctcagcc 15061 tcctgagtag ctgggattac aggcgcccgc caccacaccc agctaatttt tgtatattta 15121 gtagagacag ggtttcacca tttgggccag gcbggtcttg aactcctgac cttgtgatcc 15181 acccacatcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg cccggcctgg 15241 gagcacccac atttctctat gcatactttg ggagccattg aaaacatttg gttgcttctg 15301 tcagaaatac tattgtactt aaaaacatta atgaaaacaa agtggtctaa tgaagtaaag 15361 gctgctctgg aatgtaacag acttgatttc tagcctcagc tttgtctcta acaggtaagt 15421 gaccctggat acatcatgta gggtgctaat tgaaagctca gttttagaac tggatggacc 15481 ttgattcata ttctggctct actgtctact agccatgtga gccaatcacc atgcctcagt 15541 ttccttctct gcaaaattgg gttagtaata gtatatgcct cattggattg ttaaataaga 15601 atagataagc acttggccca ggggcbggta cataacaagt actctaaata aaggagttat 15661 tttgaaatga ttatttcaag ccatcttttc ttttttattg gtgaaatgaa atgattggag 15721 atgtatctct aaaagctttt tctaaccata agagtccgta aaatgcataa tgtaaatgtc 15781 tcaacaatta taaatgaaaa ggaacattag attcagagat gattcaccat gcaaaagaaa 15841 tgcaaaagca ggatgtagat cacactaatt agatttgaaa aaggttttgg atctaaaaat 15901 gtgttctaca taaagcatgt tattgatgct tgaaaaatgg tgataatagt aacatgatgt 15961 catcctagct tggggggaat gataccatac aaaaataacg tgtcaacatt aagaatggag 16021 tttgagtctt taaagaccca cctattagct tctaaaacaa tgtaaggcca tgtacacata 16081 tctaagaatt ggtgagtatg tcaataattg ctcaatttta taacggtgcc ataatcccat 16141 actattacac tccatccatt caacaaatat taccaagtgc ttactacagg ccaggtacta 16201 tgctaagcag tgagaataga cagaggaggc agaataacat agtgaataag atcatgaggc 16261 caggtgtggt ggctcatgcc tgtaatccca gcagtttggg agactgacac aggtggatca 16321 cttgatccca tgagttcaag atcagcttgg gcaacatgac aaaaccttgt ccctactaat 16381 aatacaaaaa taattagaca tgcattgtgg cacgcacctg tagtcccagc tacttgggag 16441 gctgaggtga gaggatcacc tgagctcagg aagttgaggc tgcagtgagc cgagatcatg 16501 ccactgcctt ccagcctggg tgatgggagt gagaccctgt ctcaaacaac aataacagca 16561 acaacaaaca aaaaaccaaa aacaaacaaa aaagatcatg gactttgaac ttcaacagac 16621 ttgagttggc atcttggttc tccacccact acccatgatg tttatactca acttccctaa 16681 gcctcagtgt cctcaattgt aaaatgggag tagtaatagt agctacctct tagagcagtg 16741 aggattgaaa aagaaaatac gtgtaaggca cttagcacaa tatctgtcac atagtaagaa 16801 ttgagtttat tattattatt atcacagatg aatagacctc atgaagctcg ccgttcattt 16861 cctcgggacc cagcctatta ggaaacatta gcaaaagttt ttgattcagc attatatggg 16921 tcattcttga tatgtttttt cctgtcaaat cctcagtttt ctattaaaaa agaatttttt 16981 tttttttttg agacagggtc ttgccccatt gcctgggctg gagtacagta gcacagtcat 17041 agctcactgc gacctccatc tccctgtgtc aagcgattct tccccctcag cctcatgagt 17101 agctggaact acaggtgtgc accaccacac ctggctaatt ttctttttct ttgttgaatt 17161 ttagtagagg caatgtcttg ctatgttgcc caggttagtc tcgaactcct gagttcaagt 17221 gatcctctca ctttggcctc ccaaagttct gggattaaag gagtgagcca ccatgtccag 17281 cccatatttt aaaattaaaa ttaaaatttt aagattttat tttggtagag acaggggttt 17341 tgcaatgtcg cccaggctgg tcttgaaccc ctggcctcaa gcagtcatct tactgcatgc 17401 ctcctaatgt gttgggatta taggtgtggg ccactgcacc tggccaatcc ttagttcttt 17461 ttgagacctc tgactgcctt attttgacag gctctgtaac ttttgcagct cctggcacat 17521 cttgctttta cttactttta cattttctcc atcaaatgtt cactcattta ttccttcatt 17581 ctcattcatt cagtttatct actcaataaa cacatattga atacttacca tgtgccaggc 17641 actgttcact ccctatacaa acccagtgac tcattaacct accaagacat ctcttactga 17701 gtattctcac ctcactgggc aaacattgct aggccttcat ctacacagat cgcaggaggt 17761 ccaaactaat tgttgacctg ggtccatggc catttcagga cccctgcaga acaggagaaa 17821 tagttcttct ggtctcatag gattatgttt aagaagaaac tttctgcaaa tgatttcact 17881 ttgacaggga caaaagtgag caggaaacac tagaccaagg tcaaaaatag tttttaaacc 17941 aagtgcagtc attatgtaac ttacttcctg ttgaatattt ttcttgaaat ctcagtttag 18001 catacagcat agaattttgc aagaaactcc tcacaggcca cccaagttgg aaaaggtatt 18061 tcagtcatcc ctatatggtg gtgaatataa gtttgctctt ctgaaaaaaa aaaaaaatca 18121 gcaggtctga aaacgattgc atagggttaa atgagccgct tagtctctga acagagaatt 18181 ttgcttatga cattaccatt gcaattatac atgaaagaat ccttcaataa atgcagagta 18241 gtagaggatt ctcccagaaa agactgtaag attgttgtaa aatactttac ctggagtgtt 18301 aacttatctt tgttctaagg ttgcactttg gtttgtcctg ccctctcccc caaaaaggtg 18361 ctgacaacta gaagtaacaa atgcaaagaa ataggggaga aaatattaga agaaaaagaa 18421 atcagttaat ttacaaatgt cagagatact ggatgtagga ggcagaaggg agaatgacag 18481 ggtattggca gcaatttaga attagtcaat acccttgatg ctaccatgta gctactcagt 18541 tatctaagta aatcccagtc cacttagggg ttgatttccc accactcaat ttgaatggtt 18601 tgtctcagta gacaagggtg agagctttga aagccaccac taagcttgat tagatttgtt 18661 actttgtacc tatttcagta tgtaaaattt atacattgta ttaaagtaac actttaagga 18721 ttgatctata catgtataca caaaagatat ggaaggaaat gcctgacagc aaaaggtggt 18781 cgtgaagcat ttgtgatatt cgtagagata aaataaacaa aaataaattc agttccaata 18841 gtaaactgat caattttctc atacacatta ttgggcataa ttttttctta cggtttcata 18901 aacacaggta atcctgggca agaacaaaga aattatctaa atgaaattgt cctaaaattt 18961 tccaaacaca gcaggaaata taataaaata ttatctatta ccaaaaagtt cattatcata 19021 atttgaatta tttggaatac taagctaaaa tacagaatta tatgtgtatc catactatta 19081 acatacttta tggtatttta acagtaaact aaattagaag tactgttcag tgtttttgta 19141 gagtctaatt tctatgtcgt taaatataat cttatattat tatataatat aatcttatat 19201 tattatataa tcttatatta ttatattata taatcttata ttatataatc ttatcttata 19261 taatcttata ttatatgctc ttatataata taatcttatt atataatctt atcttatata 19321 atataatctt attatataat ataatcttat tatataatat aatcttatct tattatataa 19381 tataatctta ttatataata taatcttatc ttattatata atataatctt attatataat 19441 atattcttat cttattatat aatcttatct tattatataa tataatctta tcttattata 19501 taatataatc ttatcttatt atataatata atcttatctt attatataat ataatcttat 19561 cttattatat aatataatct tataatataa tcttaactta ttatataata taatcttatt 19621 atataatctt atcttattat ataatataat cttatcttat tatataatat aatcttatat 19681 tattatataa tcttatctta ttatataatg ttatattatt atataatctt atcttattat 19741 ataatgttat attattatat aatcttatct tattatataa tcttatatta ttatataagt 19801 ataatctttt attatattat tacataatat ataagtataa tcttatatta ttatataata 19861 ttattattat acaataataa tgtaaactga ctattgcagt ttacatggtg agttttattt 19921 ctgcacagat taaactttct atcatagagc tcttcttaaa agattctgaa tgactactca 19981 atatgtaggc aacttattta catactcaga taccttgcat gatgcaattc tgtaatataa 20041 actgattttg gtttttgaac ctcgtgttac atttctaatc caccagacat actttttatt 20101 caaaggtcta attgattctc atggattaaa ctggaatcct gtagtgatta tttttgtaag 20161 gtaaaaatgt ttgtgtgatt gggataatga ttccaaatgt tttgtttttc aagttttaat 20221 ttttgcatct tgagttgaaa agtacacctt taatgaatag acaattcatc aaaatgttat 20281 acctagctcc tgaattaatt agggtcattc atcagaaaac tgattatgta aaggaccaaa 20341 cagcaatgat aaccttcaag cctctgggat aggtagggct gtttgctcct gtgctaaatg 20401 ccctaagttc ttgttatcgt gtctgcbggt ggtagttatc ccattttctt tttcactctg 20461 ctgtccctgg catcatcttg tttctgtcag tgtaaatgcc tttagcaatt ttcagtgact 20521 ctgaaaacca gacaaagtga atttgttagt actggatttc aagaaagagc aaaagtaccc 20581 tctgagtgaa agttcaagag tcttcctaca agttaaatgc ctgaactcta gtccaagtgt 20641 ttggtgggag gtattttgca tgcataatag cttctccccc atttccttac tcttcttgaa 20701 tgtgttccag agagctgagg ttgctggcaa agtgactcct agattactta aggttcatta 20761 agtacttaaa gttcattaag ctcatacata attgtcacca gattatcatt ataattattt 20821 taaaagtagt ttatctgtga aaataagtaa aatacatttt ataaatgtta taaactataa 20881 gatgctccat tattttatct tcctataaaa tatgtctata aaaaagctca tttaaagaaa 20941 agttaccttc actgtgagat tgtctcaaag aaatgtctca aagatacctt cttaaatcct 21001 gccttctaca ggactgaagt taatataaca aagatattag tgttcttcct tgggattctt 21061 ccttgctaat ttccttgaaa acacccttga ttcccagaag tctcctattt acaaaacaaa 21121 actagttttt cttgaattga ttcatctgtc tacttaaaga ttttttttgg ccagttgtgg 21181 tagctcatgc ctgtaacccc aacactttga gaggttgggc aggaggattt cttgaggcca 21241 ggagttcaag accagtctgg gcaacaaagt gagacaccat cccctgcccc cacctcctcc 21301 cgccccaatc tctacaaaaa ataaaatagc ctatttattg tactctctac aataaataaa 21361 ataaatatag atgcctgcct gtagctccag ctactctgga gggtgatgtg gaaggattgc 21421 ttgagctcag gagttcgagg ccactgtact ccagcctggg caagagagct aaaaaaaaaa 21481 aaaaaaaaaa aaaaaatttt ttttatgtta tcttagttca agtttgagaa ataaaattaa 21541 gtaccaaatt tattcccaaa aatgtatgct tgtcaggaga tatacctaat gttaaatgac 21601 gagttaatgg gtgcagtaca ccaacatggc acacgtatac atatgtaaca aacctgcacg 21661 ttgtgcacat gtaccctaaa acttaaagta taatttaaaa acaaaaaaca gaaaaaaact 21721 acagattcaa ttcagcttta ggaattaaaa aaaagatttg atgtaattat atcattataa 21781 aatcaaattt tttaaataaa acatgaaatt gttttaattt aaaaaaaagt atgcttggcc 21841 tatatgtcaa ttcaatagct tttctttgcc agaaagaatg aagtcagtct acctgtatcc 21901 acatatgaag tattttagga ttttttgtaa ttttttgtta ttatctatat cattcaggtt 21961 taggaaagaa ctttacctaa aatactggct aattgtgccc caaaaaaaag aaagctagaa 22021 agaaagaaca cacacacaca cacatacaca catatacaca cacaaaaaaa acaaccaact 22081 gatcaactgg gagtttcagg tttatcagcc tttagtctca atgctgtatc actgtagtaa 22141 aaatcaggct acttgatagc acctagaaac ccattttaaa atataaactt gtaaagcatt 22201 tctgtaagta aaagttagta tgtttataat gacatttttt cttttaagac atctttatta 22261 ttatcataaa aaatacagag aagcaaaaat aagaatgtag aaatcaccca gtttttcctt 22321 tccaagtaaa caatcataaa aaacttggtg tatatatata ttgcagcaat tgtatgtatg 22381 taatggtctc tgtatcaacc aacacatttt tatcatttta ctgaaacttt tgagtgttgt 22441 ttgatgctga tatcatggtt tttcatgtgg gaagattcat atgagaattg attgtgtgtg 22501 tgtgcgtgtg tgtgtgctcg tgtgcgtgta gcagcaggaa gtatataaaa ttattttctt 22561 tttatagacg ctggttgaga tttttcaaaa tattggtgat accaatcttg ctgatttcac 22621 tgctggattg ctcaccattg tcgtctgtat ggcagttaag gaattaaatg atcggtttag 22681 acacaaaatc ccagtcccta ttcctataga agtaattgtg gtaagtagaa tatgtagtta 22741 gaaagttcag cattatttgg ttgacaaaca aggaattatt aaaaccaatg gagtttttaa 22801 catcttttgt tttatttcag acgataattg ctactgccat ttcatatgga gccaacctgg 22861 aaaaaaatta caatgctggc attgttaaat ccatcccaag ggggtgagtg tggtgttcct 22921 cttagtacta atacattaag tcagtaagtc agtctttttt atttaaataa aaccttttat 22981 tacaagcttc atttcactga tactccttca atagtcctat ttgtgtgtga tctggaagaa 23041 acaaccataa gacaaacagt atgtgtgtag ataaacgtca agccatttgt ttaaaagcag 23101 cccgtatatg ctcttttttc ttcattttct taaaacatgg cagaacatgt acggttaaca 23161 ccagagtcct gatttaaact tatacataac attataatat aatataaata gaatcatttc 23221 tcagtaacat ctattgcact gtgaacaatc tgcttaagga atcagggacg tctggcctaa 23281 attctctatc atttagttta atcaattttg gataataatt atatcctcgt acccataagt 23341 aaaatgcatt atcttcaagg gaagttttag aaacatttgg tagtttggtg aattagaaga 23401 gtaaaagatc aaggtccttc attcatctct gtcaccttcc agttttgtga cctgaggaga 23461 ttctcctata taagacaagg ataatgaaaa cagccgaagc ctcaactcaa gcttattatg 23521 aaacaccagt gagatctctc atgaaatgaa gagtagtcaa gacaccctac accataattt 23581 tctcatatgg ggttacaaag gaggcctaga cgtttattat atttgtaaca tacactcata 23641 acatttaaga ctagacttgc tgttaatcaa gaagtactag ttttccctaa gactggaaga 23701 gtttggtacc ggtgtttcta ccaggaaagg gagtggaggg gagggaaggg cacggagcca 23761 ctgtttggta ccagtgtttg ttttccatgc tcttaataga aacttcctca ggcaagctta 23821 ttcccagagc ttattctaca gggaactgct gtattcccat ttgatgaatc ttataatttc 23881 ctctaatatc tgttccaaac tatttgaaaa agcacagctg gctacatggg acttaatttg 23941 catgctatcc attacagtgt ttctcaaact tacccttttg taagaatcac atgggatcct 24001 ttttcacaca gattcctggt tcccacccca aacctattga atcaggcttt ccagaggtgg 24061 ggctcaggaa ttaatatttt tcaaaagtgc ctcaagtgat tcttgccctc aaggaaactg 24121 gagaaactct ttaagagagg atcaacaaat ctaatctaac aactagataa tttcattagt 24181 tagaaacaat tacagaaaaa gatactttac agatctcttt tgtcaggctt cctaggatgt 24241 atcaagttat aggtggtcca cagagcaggc cctgtcccat ccatccgtgt tccattagtt 24301 ggtttaggga actcatttct tctgccctaa attatccctc caggtcctct gcagagcttt 24361 cctgtgctct cctcctgaga acagatttct agcctctcgc ccttgagttt aatgaagctg 24421 aatcctttga cagaccacct ggtcagcttg gtcagctaat ttaacctgcc tggccccagg 24481 gactttaagc tactccatga gggcagtgac cccattggtg ttgttcagct ctgtcccaga 24541 gcacagagct catctcacag taagctctca gaaaacactt gttgaaggaa taaaataccc 24601 aagcctatgt cattataaac aagccacaac aaaggccttg gttatctgat ctcacttggt 24661 agcacagaag caattctgat gatattaaca aacctgaaaa agaaagggag tggagagatt 24721 ggaaaaaagc aagcagagtt ttaaagtggc cctgaggtga gcacagtgaa aggaagaggg 24781 acagagagat tgtgatatgc ccccttttga tctcctccct gcttcaatcc tccattaagg 24841 ctgctgctcg tagttccctt tatcctattg agggtccata agttaggatc actcctaacc 24901 taggaccata cgttaggacc ataagttagt ccccaataac aatgccccat tggacagcca 24961 aaaacagtgg ctccatgccc ttccctctac tccctttcct ggtagaaaca tacaactttt 25021 ccttgtccag tcaacaccta agcgccccac taggattcac tcattctccc atcctgggtg 25081 ctttcttaac cagcagacac tatgagggcc agtcatgtgc ctctcttctc atgcaactgg 25141 tccttatctg caactcgtaa tctgcccagt tcctcactca tcctgcccag gcttctcttt 25201 tacctcttct gttatagtgg tgtgtgtgtg tctgtgtgta tgtgtgtgtg tgtgctcacg 25261 cacgtgtatg tgtaaaccca taacaagatt gacagctctg tcctctaaat tttaatccct 25321 attcactctc ttgcctcctg tccttgccag ttccagaggt ccccttgttg tcatgtttgt 25381 tactctcttt tttcttttct tttctttaac agagtctcac tctgtcaccc agcctggaat 25441 gcagtggcat gatctctgtg gtgtgtgtgt gtgggtgtgt gtgtgtgtgt ataaacccat 25501 aacaagattg acggctctgt cctctaaatt ttaatcccta ttcactgtct tgcctcctgt 25561 cttcgtcagt tccagaggtc ctcttgttgt catgtttgtt actctttctt tcattctctt 25621 tctttcttcc cttccttccc tcccttccct ccctttccta ccttccctcc cttccctccc 25681 ttccctccct ttcctacctg cactcccttt cctccccttc ctaccttccc tccctttcct 25741 ccccttcctt ccttccttcc tctctctctt ttttctttct ttctttcttt ctttctttct 25801 ttctttcttt ctttctttct tttctttctt tccttctttc tttctttttc ttttcctttc 25861 tttccttttc tgaaacagaa cctcactctg tcacccagca tggaatgcag tggcatgatc 25921 tcggctcact gcaacctctg cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 25981 gtagcbggga caacaggcac acactgccat gcctggctaa tttttagtag agacggggtt 26041 tcaccatgtt ggccaggctg gcctcaaact cctgacctca ggcgatctgc ctgcctcagc 26101 ctcccaaagt gcbgggatta caggcactgt tatagacccc ttttgtcagg tttcctagga 26161 tgtatcaagt tataggtggc ccgcagaaca tgccctgtcc catcaatctg ggttccattc 26221 attggtttgg ggaactcagg cctactgttg tttttaaagt atgtgctttg cagttgtact 26281 tgaaagtgtg gcacaggggc aaagccaaca aaaccacagg gtttttttcc tggctgcttt 26341 ctgagggcta ctcttctcct ctagctggag tggtggtgca tttgccaagt gttcagaccc 26401 agtctgaagt actctggtat tctgtttggt attctgttta tgacgctggc ctgtcgtttg 26461 tggaattttg ggcccttcag ggttcacttc tcccggtctt catcttttca gataagtgtg 26521 tgttcacatg ctcactccct tgggctcttc atagtgttgt cttatgatca ggcctgacat 26581 gcttggctgg ggccaaacag gcccactgag caaaaaattt ggagagttat atccacagaa 26641 ggagggcaag ggcaagggca aggacaaaag gcttacttac aggtcattag aagatatcca 26701 gacgggactt caattggttt ggggcaaata attggcacac ttagggttca gcaagacagc 26761 agacatgagt ggcaggagta tgacagactt agattctccc aatatatacc aagaacctac 26821 tatatgtgta gacactaatt acttacttac acaagtgatt cctcattgaa tcatatgaga 26881 agaatatata gtccccattt gacagctgag gaaactggga tgtggtgggt ttaaataaca 26941 tgcctaaagt catttgagag tgattctggt cctttgactt aagtctttgc actttacact 27001 ttgcacacct ggataatcaa ggatcaggtc atatttggag aactaggcag ccaggcaggc 27061 aaagtgcatt aggctgctat caaaactaag ctgtatgtga aactggaaag ttatcctgac 27121 aagtccgagt gacctgaagt agggttgact gggtctcagg agcaagtcag gagcctgttt 27181 tgagaagtgt ggtcccaagt cacatcccaa ctagcaggtg atgtcatgct gagtcgccca 27241 actgttggat cagggtttcc aacatcctgt ctgtctacag atggggttca ttccacagtc 27301 tcattgbggg gtaggatggg atataaggag aaaaggagtc tgaaaattaa cctcactggt 27361 agggagagta aggctacaag ggcagagaac cagacagatc ttgttaggta ggaaatcgtc 27421 taatatctaa catttagacc tggacccact aactgacatc aagcaaatca cttcacgttt 27481 ccaggtctaa gttcctttat caacaagaca agacaagagt ggtggattca acaataccta 27541 ggatgctttc tctatggttt tctctaagaa ccttatttct attttatttt taccactgtt 27601 ctctaattat aggggaaaat gtagtttcct tattaaagaa actttaggca taagtgatgt 27661 aggtcgggga gacctttcat ggcbgggggc ctctggaatt ataccatatg gatagtcatc 27721 aagatatagg tccatctccc aaattttcat atttgagaga acctcgtggt ataatgtgta 27781 ggttaatttt tttatatggt ttgtagggta gctctggttt tgtcaaacag tagtcattgg 27841 accccacaat cactgagata ttttagtcac tatggagcgt tgtgataatt acattaattt 27901 aatctttttt gccttaagaa gattttaaat gtcctggctc tcaaaggatt ttccactgag 27961 ctcttttagc ttcatacatt ctttgtctct ttaacagagc tgatacctct tcaaacacag 28021 taaatctcat attatggcta gaatctcttt taaattcaaa gaactttaag atggaattgt 28081 ggaaggagaa acactaacat gtgaaatggc atggatgggg ctgtatgata ttaaagaatc 28141 agtaacagca gatttattca tgtgagagat agagaagagt cagcatggct aggctcaaaa 28201 atagaggaca aagaaatcag ccagtaagat aacaccaact tctgattaaa cattataaaa 28261 gctgctacta tcatgtatgt atttcgtgtg ctttttgttc ttttggatca agtactttca 28321 tgtctaatat gtgactgagc agatatagca tttgatgaga tggggaaaaa ggatggtggt 28381 caaatcttca cagcattttt cacttaaaaa ctcactaggt ttttgcctcc tgaacttcca 28441 cctgtgagct tgttctcgga gatgctggct gcatcatttt ccatcgctgt ggtggcttat 28501 gctattgcag tgtcagtagg aaaagtatat gccaccaagt atgattacac catcgatggg 28561 aaccaggtat gggtgccctt ttgctgaact ggttttatag ggctggaaac aggaaaaaaa 28621 cataaatgga aaagattttg gtgtcagcta aagaaggggt tggattcttt caccagacct 28681 tattgggttg gttttcctct tgtgtttgct aattagaaat tattttggaa tagacacact 28741 gcatcacttt gcttttttaa gaaataagtt gaaataacac taattttaaa agagctaatt 28801 cagtcaggtc ataaataaca ttcaaagtga acatattagg tcagaaagag aattcttcat 28861 gtaacccagt acctcttggc aattattttt aacggcagtt ataatgtgac aaaacagtgc 28921 aacaaacatt aataatagtt gtgaccactt taaattgagg tggttcactg tgcagttaat 28981 atatacaggc aatttttgta ggcatgtgat acattgccag gtaagctgat ttcacactgc 29041 ttgcaaattt gcaagttctg tatctatatg tttctgaaaa tacagtatag caataacagt 29101 agttaaatgg ttagtaatca agcagaataa cagcactgct agtcataata tgcttcatag 29161 tgaatattca accacagaaa aacactttat gtgagagctg cagacattcc attcactagg 29221 cagtgaaaaa gcttagcaaa tgatcaggtg ctatttcttg tcaactttaa aaattatcga 29281 gagcaatgag acctctctca gatggtatgg cgtccaaact cctgatgtcg tacaaggacc 29341 ccaagtacct atcacggtaa aaattaaatt ggaccaccac gcagagtagg catgggagtt 29401 ttcattctta atgtacttcc tgaaatactc agcgaaggtc ttgcaaagat tcaatttgta 29461 ggatcgttgt catccagtct cttccttagg aattcattgc ctttgggatc agcaacatct 29521 tctcaggatt cttctcttgt tttgtggcca ccactgctct ttcccgcacg gccgtccagg 29581 agagcactgg aggaaagaca caggtaggaa caacagcctt atgatatcca tctcagagaa 29641 caagtcgagg aatggcaaca gaggaaggct cgcaccgagc ttagcaggac aatttgcctt 29701 tcagacttgt acttcctaat ctgattcacc tcaggcctat tcctcttgtt ccactccctc 29761 acctgaaatc tcttaaaaaa caacatgtat ggttttctga tacagtgatt ctcaaatcta 29821 tttgtcagtg cttacctgtc atgtagctac acttacctgc tgtggtcaat aacaactgac 29881 aaggaatcag taatgaagga tgctgatttt tgttaatttg ttacctgggg agacagatgg 29941 cctggtaaaa gcgcttcctg gctttaggag ctattctatt ttcaggaaag tgaaaagctc 30001 tattcacatt tcctttagaa ggatcaggaa cttcctccag gggcgtttgg tcccacagaa 30061 caacagtttg ctagccaaga atatttttgt tgtaacattt ttggcatttc ttcctgagta 30121 agatttatgt tgttgaagtt ctgcatgtgg gtttaatctt atcttttaaa tgtggtttgc 30181 agttgttgcc tttacaaggt ggccaaaaag ccagcatcct agttaatctc tggataatcc 30241 ctccttcagt gttcagaaag ctcaggagcc atactcaaag gccactcttt ccagcaggac 30301 acagtcgaag agaccacacc aagcagatgg gcacaagaga cagactcagg aattttgctt 30361 ctgtctctta tgccttgagg tccttatctt cccaacacag aaagaactat tatttaggag 30421 taagaagtgc attgagactc caaagaacaa caaacccaaa ctacatagtg caatacacac 30481 acacacacac acacacacac acacacacat gcacacacac atgcacagtc ttcacagtct 30541 tcaaatgggt tttactaagg cggggacact taaaaaataa atataagtcg ggcacagtgg 30601 ctcatgcttg taatcccagc actttgggag gctgaggtgg gcggatcaat tgaggtcagg 30661 agttcgagac taacatggcc aacatggtga aaccccttct ctactaaaaa tgcaaaaatt 30721 agccaggtgt ggtggtagat gcctgtaatc ccagctactt gggaggctga ggcaggagaa 30781 tcacttgaac ctgggaggtg gaggttgcag tgagccaata tcgtgccact acattccagc 30841 ctgggcgaca agagctagac tctgtgtcaa atatatatat acacacacac acacacacac 30901 acacacacac aaacatatat atatatatat attctcatat atatatacga gaataactga 30961 aaaaactaat gactccaaca gtgacttgcc cagggagggc tttaattgtc cccaatatgc 31021 atgtgatgct cctttcctat ttataatgga tcttgtgaca gacttggaag aattggcctc 31081 ttccagtttt ttggctgctt ttcaacaaaa aattttattt tcagaatttt tcttaatttt 31141 ttattttttt tgcaaatatt tccagctctg agggagcagg taaaataata cagctcatat 31201 ccggaggcat agccagagat ctgtggtcaa ggggaagagg tcagagccaa tttccaaagc 31261 tgtgcacatt tcaggctgca gcbgtcagca gcaggaactt ctgctgcttt catttgagac 31321 ggagcactga caagctctcc agagcacatg gtcttcagcg ggtgcaggca aatctcaaac 31381 tgctgatgtc cattctcctg atgttacctc caggctcaaa tgaggcatgg gctggctgtc 31441 ccagtaagta tgcccatgta aagtgacctc cttggcacag ggtttggggg ataatggtgc 31501 tctggtaagc taataccccc tgccacatac tggcatgtat tatatttagg aatgaaggat 31561 gccaggattt cagcattaaa gaatgaaacg agtaaagaaa tggcttcatg tttaattatt 31621 gaaatgtata ctaaattctg gggttaaaag tctaagtgcc tgaactgaaa tccagggact 31681 gatggacaaa taaactggca gggcttctct tgtgtggctt ctcgtgtttt ctcttatgtt 31741 ggaacttcag tttcagcatc tacaaaatgg aaatgataat tgcatccatt tcacagggat 31801 attgtgagga ttaggcaaga aaatgtaaag ccttagcaca tacttgtaaa tgctcattgt 31861 ttcactcctt taggcaagaa tagcatctta gcatctatga tacatatatt gtgcctggca 31921 cataagaagc acctggcata tatttgctga atgaatgaat ggaagaatga gtattggtgg 31981 acacgaactg tttttagcac atctacagat tgtagaagaa ttaaacattg gaaccttttc 32041 tttccctcac ccccatctga cttccactga ctcacagaaa agtaattctg attacaaacc 32101 actctttagc tctgattacc ccctccctta acagaataat tttttagtaa ctgaatctgg 32161 ttgtagatat aaagtctaca gagtttctca caaacaagcc ttatcaagta agtagaaata 32221 attgatcact caccaatttt aatatagtgg ccaaaatgag ccttggcctc ccataattgg 32281 agactcatta tgacatataa ttggcaagta ggtggccact ctcctggcat gagtttggca 32341 gctgactgtg gtccttgtcc ccaaatctcc atatctttct ccagttcaca gagctcccca 32401 tccacagtga gatgcaagtg gctcggtaaa tactggttga gtaattgcat gcaaggaagg 32461 aagggaggga taagggaagg aaagaaagaa gaaaatggaa ggaaggacaa gggagaggaa 32521 gggaagggat atgaaggaaa gcgaagagaa gggagggaag taggatatca gcttctctgc 32581 ttagtcagga gaagggaaag agcaccaggg tactgggaat ctaggatggg gataggaaga 32641 gcatagaaaa gccagccaga catacaaagc acgcttttta gtacctcata cacatcatat 32701 tgcctcaggc tgacccaact ataatctaaa tataaatgat caatttgcca ggtagagcaa 32761 gtgctttcta attttctgtt tatatttgct gtgtctgtct cccgtaactc agaccttttg 32821 cactagacag tacttgtgct caacaaaatc ttcccagttg tttcctctct gattgctttg 32881 cttgtagttc cctgtctcct tttcttcttt gtttcagagc ttctaatctt catcttggct 32941 ctgccccagc tgtctcaaca gagaattcat tggtcatcta atcaaacgag agagtagtcc 33001 ccaccccctc agcctctctc ctaactagta tggatcttag gagagctatt tttgccagcg 33061 aaggtaaagt ttctgaagct tccttttacc cctgctattg ccccgttact ccatagtcac 33121 tgtttcaggc tgccttgggg caaagctctg agcctgcctc cgtggaactg tcagaggagg 33181 caggagacac aatcccacct ctcaatgtgc aaatgtggca tttcgaattt gcaataggat 33241 gagtaaattt attttctctg agactttaat gagaccatgt gctacaagta cgaagtgtta 33301 tcagagttgc tattatagct gcagcttcaa taatgcagaa aaatcagcta tgtgccatga 33361 gaatttattt cccaagaata cgacaatgat ctctgttgtt gggaaagggg ggattggtcc 33421 atgtttcctg ccatggtaaa taactagaag cttggcctga atggacgccg aaaccgcagg 33481 tgtgtactat caccaaataa aatccctgtc aaactggctt taatttcata ggatcagtcc 33541 ccatattttc tttaacttct ctgccatagc atatatagat gccatttttg ttcagttttg 33601 tggcttgagc aaataactat cacttttctc gacagtattg agcagaaggg ggagacaggg 33661 aagtatgaag tgtgtctgtg aacaggctgt ctcatacaca catccagtga gctggaagac 33721 acaagggaga aggacgaatc cttttcatag gaggtgtgtg tcttccaggt tgctggcatc 33781 atctctgctg cgattgtgat gatcgccatt cttgccctgg ggaagcttct ggaacccttg 33841 cagaaggtat aaccctgctt ctctgcatac cgattgcata atttcccttc actactctgc 33901 taccagataa ataacaggag atttaacaat catcacatgg aaaaccattc cctgaataac 33961 acagccttct ctgtctctct tggcagtcgg tcttggcagc tgttgtaatt gccaacctga 34021 aagggatgtt tatgcagctg tgtgacattc ctcgtctgtg gagacagaat aagattgatg 34081 ctgtaagtca cctaccacct atatttatct gaaataagat ttggttctta tatgcttcct 34141 gccatatcac tatattcccc ccatccccta agtctcactt gtgctttggg aactccagag 34201 gagaaattag aattgbgggg ataaatcaaa gccatgaagt cttccatgtg aactgcattt 34261 tgtgaagatt ctgtatctct gggaaggtca atttccagca agaatcccat atgaggctca 34321 ttcatacacc tttggccttc taaacacaaa aagcaaaaaa atgtttaaac accctagttt 34381 agaaggacaa acaacataca aaacaatgca aaaacaaaat acaaaatgta aaaacccacg 34441 ctgactttaa ctctgactaa cataaccttt gcaactattc tgagaaacta aaaatcagaa 34501 gctaaatcct tcagagttcc tctctaattt aaaccataaa aagaatgaga agacttccta 34561 catattgata tggaaaattt tccaagacaa atcgttaagt gaaaaagaga ccagaataga 34621 aatgctgggg aaaagcacag acacaggcag aaataaaagc ggatacaagg agggagggaa 34681 gttgggaatg ggtggagaag ggggagggtt gtgagcaaga gttttcccct ttttaatgat 34741 aattccctta tgaaccatac aaatatatta gctattcaaa aatttagaaa taaataaaat 34801 gggacagttg gtcttaattg agaagcccag tttctacagc tacttaaata taaaatgaat 34861 gaagtcacaa tatttttaaa aagctgtgat ttggccaggc acagtggctc aggcctgtaa 34921 tcccagcaat ttgggaggca ggaggatcac ttgagctcag gaatttgaga ccagcctgcg 34981 taacacagtg agaccttgtc tctactacaa ataaaagatt aaaaattagc cgggtttggt 35041 ggtatgtact tgtgggtagt cccagctact tgggaggctg aggcgggagg atcacttgaa 35101 tccagaagat ggaggctgca gtgaactatc atggtgccac tgcactccag cctgggcaat 35161 agagtgtgac cctatctcaa aagaaaaaaa aaaatgtaat ttgtttgtgg atcattgatc 35221 ttatttttat aggtagttat cacatgatgg tacctgatac attaatataa ttcttttcat 35281 ttctattttt ttccctaggt tatctgggtg tttacgtgta tagtgtccat cattctgggg 35341 ctggatctcg gtttactagc tggccttata tttggactgt tgactgtggt cctgagagtt 35401 cagttgtgag taacgtaaaa cccagatttc ctataaacag aacaacacac tctgagcttc 35461 cttataccat tttgataaat atagtgaagc cactttcttt cgttatagtt actgtatatt 35521 gagtgcttct atgcattaag cagacagtgt tttacagaca tacttaatct tcaaaaatag 35581 cctatgaata gttttgatta gtctcattct acaggtgaga aaagagaaat tcagaaaagc 35641 taagaagcat ccctaagatc acacagctag tacgtggcag agctaagatt tgaacctatg 35701 tacctactca tgtcctctac tgcbgtgctc tccttttagt tgtggtaaga ctaaaaagta 35761 catagtttag ccaaaggctg aagttgcttt gtagtttctt ctttaaatga gatgaggaat 35821 gtaaggcgct cggccccagg cttgggacaa gacagcbgtt atatattata gttcattttc 35881 ttttttaaag ctagtaacca aaagttacat aacccagaac aggaggactt taaaatagct 35941 gatgacagcc aaaattcatt caaatctctc atataaccaa taaggcatat aaccaataaa 36001 ccacacaatt atgtgaagga aacaattagc tcatatgcag agtgaaggca gcaaagacat 36061 gatttaaata atggaaaaca gcctgtgagg gaaggtgagg agcctgaagg tggttttttg 36121 gttggttttg ttttgattct agagaggcct tagttaagtg ccctcctggg cctagagggg 36181 aacagagtct ttctctccct cctcaatgtg tccatcgtct ttccagactt ctggcccctg 36241 ctctgcctgt gcttgggccg tgaaagaaga agacacctgg aaaaacatca agatagatgt 36301 cttcagctta gcatccgctc acctctcctg tcccaccagc cagttctcct tcctgccctc 36361 cttccctacc ttggcatatt ggtgcctacc caaaaggctt gtgttttcta cctcagcatc 36421 ctaaatgatt gcccaagggc ctgagaaggt ttgcaggctc ccaaagttct caatttgctt 36481 ctaggacacg tctcagaaac gctccttaga agatgcbgtc tctcatgctg tatatgcctc 36541 agtgtctatt ttttcttgtg tggatgtggt tggaaaagaa gggttttaca gagagagatt 36601 agcttataaa cttttaagtt aaaaatcagc acaaacctgt aagccaagga ataactggtg 36661 gcacatttta gctgctagtt tggtatctag gcttttagcc aacaaaaagc agtatcctcc 36721 acagtattta atttccagta attatcatgc tgatccagag agcacaatgc tgaaagtaca 36781 ctaaacagat actctttctt caggaattgt atttagcatg tctctagtca cacatgaaga 36841 gtcacggaat ttatctgatt gcatcaggaa caagaaatca atagtctggt tgacaggaag 36901 gacttatttc tggtcctcca gtctcctatt tctataaaaa atgactaagt cacaaagaag 36961 cgccaggcac tggaagaccc aggggttaaa gacagaggct ctgctgccct ttacctccag 37021 gccttttctc acttctctta agaagtttag ttaacaataa aaatcaggat aatactgatg 37081 acctttcagg gttatggcag ggcttaaata agatttcaca tgcgtgaaag ctctatgctt 37141 atcctataac gtgttgtgca cgtgcaagta tgatgctcat tatttctctc agccatcaga 37201 agagaggcac agttctcccc tcccctgccg attccacaca aacaccagct gttcatttca 37261 gagttagcta caggaaaatg tcatctgcaa taaagacaga gtccaaaaca ccagaatgat 37321 gggctcttta gtagcbgttg tttttaactt tttattccaa aatacggctg ttccaaaaaa 37381 tcttgacctt gatatttttt cttctagtcc ttcttggaat ggccttggaa gcatccctag 37441 cacagatatc tacaaaagta ccaagaatta caaaaacgta agtacctttg tgagacattt 37501 gctggacttg ggtttactag cctgaagttt cagcagctcc attttacgta caaggtagcc 37561 aaagggagaa aatgcctatt gggaaagtct gttagtccac agggagtgtc atgaaaactt 37621 ttgatccagt gcaccttctg acacccatgg cttatgtgaa ttttgtctat gctagctgaa 37681 tgtctttttt tttttttctt tttagatgga gtctcactct tcacccaggc tggagtgcag 37741 aggcaggatc tcagctcact gcaacctctg cctcctgggt tcaagtgatt ctcttgtctc 37801 agcctccgag tggctgggat tacaggcagg tgccaccacg cctggctaat ttttgtattt 37861 ttagtagaga tggggttgca ccatgttgcc caggctggtc tcaaactcct gagctcaagt 37921 gatttgcccg tcttggcctc ccaaagagtt gggattacag gcgtgagcca ctgcacctgg 37981 ctagctgaat gtcattttaa tataaaactg ttgtaagagg aatttaaaaa taataggcaa 38041 tttctagatg ttcatccaaa attttgttta tctggtatat aattcttatc ttctgtaaga 38101 ttttctttat tcagttctaa caagagatta tcaagttctc tatgaccaag accttattat 38161 ttgacacttt gctttatcct tggtattaga agaaataaaa tatgacacag gaaatgaaaa 38221 acaaagaaat taaacatccc attgatggac ttgtgtcacc tgcaaataaa attgcttagt 38281 ggtgactagg ggaaacaaag ataaaaaagc agagaaagta aatcaagaaa atacaaattt 38341 agcaaataat aataataata atatcaaccc taggaagttg tagtctaatt ttaccttaac 38401 attaaaaaaa gttggacctt gaaactggga tttcagtagc tgctacttaa tttatttccg 38461 tgatctttct gttatgttga gccaagtgcc attaagagct aaaatgattt agagattttt 38521 ttggctttgg ggagggagct ctaagctgag ttagggaatt ctgacttcta ggctccatct 38581 tggtgagact ttgcccaagt cattcagcct ctcaggacct cagttttctc atctgaagca 38641 gctagactaa aattgctgat tcctgaagac tagaaaagtc tatgattctg tgattcctgg 38701 gttctatttt gggtgtggcc attgtatgtc agggtgagaa cagatgatat cataggcctc 38761 agttctgcaa atcccattga ttttgctttt tttctttgct acttttaaag aatgttagca 38821 aaatcaggag ggtcagtggt atgaacttca ggcaaatcat ggcactgttc taagcctcag 38881 tttcttttct ggaaatcaga gggttgaata aattgctttc taaggccctt tctaactttg 38941 accttctatg agactgtaga ggtccaagag tttttgtaac ctgttgtctc cctattcaag 39001 aaaagttgta gaggccgggc acggtggttc acacctgtaa tcccagcact ttgggaggct 39061 gaggcgggtg aatcacttga ggtcaggagt ttgagaccaa cctggccaat gtggcaaaac 39121 tctgtctcta ctaaaaatgg aaaaattagc tgggtgtggt ggcagcacct gtaatcccaa 39181 ctacttggga ggctgaggca ggagaatccc ttgaacccag gaggtggagg ttgcagtgag 39241 ccgacattgt gccactgtac tccagcctgc gcaacagagt gaaactccat ctcaaaaaaa 39301 aaaaaaaaag aaaagaaaga aaagttgagt gctgctaccc agctcctctg agcaactgtg 39361 acttgactcc ttgctaagta gccagaaatg taattaaata cttgaggctt gaaattattt 39421 aatcccagac aatttctttt aatgccagat tgaagaacct caaggagtga agattcttag 39481 attttccagt cctattttct atggcaatgt cgatggtttt aaaaaatgta tcaagtccac 39541 agtaagtatt ttatccctag aaatttgttt tctaacctct tttgagactt cattcattct 39601 acaagtattt actggggtcc aatcaggaat aggccctaga ccctcttccc tttgtgtagg 39661 gcaatgagaa ttaaaatata acatccttgc cttcaaataa tttacagtct atttggggat 39721 taaaaaaaca catatgttaa aacccaggta gtaataacta tgccagacaa aaacattaga 39781 gatgtttcta ggcagaattt gagtaagttt caaataagta gtatagacag ttgagagttc 39841 atagaaggaa gagatccagg ttagttggac taacaggctt tgtgcggcag ttggctgaag 39901 gaaagaaatc atgtcaagtg tttgagaact atgtgagctg agagacagtg gaaacatgta 39961 ttggaggtag ggttgcccag ttgcagcaaa aagtaaaata tactagtgga ataaataagt 40021 agaaaatcct ggcaccaaat gccatgctat gctttgaact tggagtttgc ctctaaatca 40081 gtgtttttct aagtgagttc cagggcaaac tgattcagag gaatgttcac agattttgca 40141 ataacaaaag ggctctgtga taccaaggga atttggaaaa cccagactta aactaaagag 40201 ggtattttgg ggtgtgtgtg tgtttctgtt ttgtctttta ctgtcttgga gcctttgata 40261 tgctactgtc ttctcagagc ttctgggtag gagtagggta gcctgggagt agacagagat 40321 ctactccatc agaccttaca atttcttttt tggcaggata gctcaaggaa ttataccctt 40381 tgagaaatag cctttccaga taacagttgc cattaataag ctttaggtgc caggcatttt 40441 aagtaacttg acatttattt ccaaaggttg gatttgatgc cattagagta tataataaga 40501 ggctgaaagc gctgaggaaa atacagaaac taataaaaag tggacaatta agagcaacaa 40561 aggtgagatg acatctttct tttccccctt aaattatttc ctttccctga tgagagcagt 40621 tagagggtct aaaattaaat ctatcctctt tagtatccag atgtgaatga acaaatgaca 40681 tgtacgtatc aaagaacaac tgagctattc ttataggcaa gcgggagtgg aagggaatga 40741 aataaaatca gcagcgctgc ctggaaacac aggatgtgat ttttttcccc accatgaaca 40801 gtgtctgcat tattttctat actttatttt tactgaaagg aacaaaataa gtgcaaattc 40861 aatgccagaa aactacccac catagaaggc agtctaagtc cataaacttt tggagctgtt 40921 aacttttact cagattcttc tggccagtgt atttcttggc aaagttccac aatcatccag 40981 aaaacaaaag tttcctggct cctctgttct cccagttttc ttcctagaca acatcaaagt 41041 ttgggctgag gtgaaaccca tccttaaaaa ttcatctcct tgatgtcttg cttaccaagg 41101 aacagtgtgt aggtcttttg gataatttga tatgaatggt tgaaagattt caaatctttg 41161 acaattaagt tgacagtgtt ttcttcgttt agaatggcat cataagtgat gctgtttcaa 41221 caaataatgc ttttgagcct gatgaggata ttgaagatct ggaggaactt gatatcccaa 41281 ccaaggaaat agagattcaa gtggattgga actctgagct tccagtcaaa gtgaacgttc 41341 ccaaagtgcc aatccatagc cttgtgcttg actgtggagc tatatctttc ctggacgttg 41401 ttggagtgag atcactgcgg gtggtaaggt tctggttttc tgaattatac atttggagct 41461 ttggcaatag taaaatgatg tgggttgtcc agtattgcaa cagggcaaat acatgggctt 41521 tgtaattttt ctaggtgaat gcttttgtaa aaaagtgtaa tattttaaag cataggctct 41581 ggagccagac tacctggggg agatactggc ttcaccactt actagcagta cgaccctggg 41641 caagttgctt aatctgtcta tatctcagtt tcttcatctg taatatggag gtaatgatgg 41701 tatctacctt cacaggttgt tacaaggatt aaataagcta atagatataa ggtgtttaga 41761 agagtgtctg gttcaggctg ggcatggtgg ctcacgcctg taatcccagc acttcgggag 41821 gctgaggcag gtggatcatg aggtcaggag ttcaagacca gcctggccaa tatggtgaaa 41881 ccccgtctct accaaaaata caaaaattag ctgggcatgg tggcgcacac ctgtagtccc 41941 agctcctagg aggctgtggc aggagaatcg cttgaacccg ggaggtggag gttgcagctg 42001 agattgtgcc actgtactcc agcctgggtg acagagtgag acttcatctc aaaaaaaaaa 42061 aaaaaaaaga atatctggtt caaagatact ccccagcaaa ttaattcaca tttattatgt 42121 tttatctttc tgagaatgta taacaagtgg tatatgaaaa gaaaaaaatg ggcaaaagtt 42181 tattaagtat tacatttcta tttgttatgt taacagcaac aggataagga ataccaggtg 42241 tatgttagga ctggaaaagc caggcattat taagaggtta gagtaggaag caggtcagac 42301 atctggaagg tcaaagcaag agttgaggag tatgcaggat agaaacatta atgatatcag 42361 aaaccagtta tgcaagctga agttcattaa ttctgtcaac aaatagatgt gaaatgccta 42421 atgtgtactg agcactctgc caggcacaag agactagtga tgaagtagac acagtttcta 42481 cctacgtggg acttagcagt ctggaggaga aggcaaacat taagtcatct tataaataac 42541 aattgtagta agtgctccaa agaagatgaa taggacatca cctgaagcat caagttcagt 42601 gaagcttcag gtaggtatca aaagggtcag gcagaaaagt aagcaggtca agacaccaac 42661 aatcagatgt aataatataa agctgactcc taactgaggt tccacttagc taaggcttct 42721 ttgctacctc tataagggga ggaaatgatt ccaggatgtg ggtactaggt aggtagggta 42781 gagaagtgat tgtgcttggc aaaagagtat gagaatatgc tgacaggttc tgttctagtt 42841 ctcttagcag attttgttat tagctcattt gaaatcactc ttgttctttg ttgtacattt 42901 cactctaagc attggctgag atccattgta gactatattg gccagagagt tcaatgaatt 42961 acttttgggg acagtcttaa catatttaat gccagaatat ttcccacaca acgaatattt 43021 actttcaaat attataatga cagttatgat agctaaagaa gactccaaac tttatacttg 43081 aacagaggtc ttgatttgtt ttcctccata attctcaaat tctcttttat tattgactat 43141 gggtcttgtg tcttgacttt ttaaaattaa atgtttattt tgacataatt gtaaattcac 43201 atgtagttgt aaggaataat atttagatcc tatatacccc ttacccagtt tctcccaatg 43261 agtaacatct tgtaaaactg tagcataaaa tcacagtagg acactgacat tcaaaataga 43321 ggccttgact tttaggtcaa tagtaacatt ttgaacccga taagcatagc cacacccata 43381 tctcttctcc aatcagcagg gcctatatta agaagcctcc tgtactctct tctttccaca 43441 aatgcttatt tagcacctcc acgctatcaa gtgcbgtgct attgagcgct ggatgttgcc 43501 atctcttgag atataatcct aattatacca ttactgtagt ttgaaaacct ccatggtttt 43561 gcaataataa cctttcctta aagtcctgat taaccatgaa agtaataatg tttctcctga 43621 gcaagtaact gaatgctact gaattatggg cagataaggt tgttaattgt tacaaactct 43681 ccttttttat ttttagattg tcaaagaatt ccaaagaatt gatgtgaatg tgtattttgc 43741 atcacttcaa ggtaaataca tatatctaca tatctacctg taagactttc ccgtaagccc 43801 tttctcctat ctgggactgt ggtcacatta tgtctgaagg cctttttttt ttttctttta 43861 aagatctcaa ttgtcattat ttgcagttct ggaatctggc actgcttcat tccataaaac 43921 agaataagtg ttccaaggaa ctaagcagga gttcagtatt atacacagaa aaggccaaag 43981 acagcaaaag caagcaacaa agagtatatt agtccattca aagttacttt cttgtaagtc 44041 agagacagtg agacagaaca ataggaaaat aatggattag ttaacatgag gtcatgtcag 44101 gatacttttt tgtatgagga ttattgcaga ggaagcttta ttattatgcc aactggaaat 44161 ttaaactgtc ctgttttagg aaatttgcta ttacctctct ctcctgattt cttcaagtat 44221 cagataacaa tttagtttag gtttgataac ttgaaacttt agcatgagtg actccatttt 44281 gatttttagt cttgtctgtt gtcgtctagt gcgggagctt agtctaaaac aatggccttt 44341 tatttttatt ttttatttta ctatgtgcct gtgccttgca tgaccccagg atgggcacag 44401 ctgcttggcc cctgagccac cgaaggctgc tctactcctt cgttctggct actaaaagct 44461 gcaaagctct gggagggcaa agctcaagaa gactaaaaca atggccttta ccatttttgt 44521 ttgatgattt tccccgtttt gatcaggctc tcacctaggt aagagtgaac aaaatgtagg 44581 agatcagtgc tactctgtta ccatcatttt gggtttctgg tctcaggagg tcatgtgtag 44641 cttatggtgc cctcctcatt atcatgtatg tctctgagtt tttgttgttt cagagagaga 44701 ccattcgatg tctgacaggt ggctttttgg aaacatttaa aactttgaga gggtataatg 44761 taccaggaag actgctatta tgactatcag ggagataata ccaagggttt atagtatgct 44821 ccttagccag gattctcatg aatcaaacca actaaaattg aatagcctga caaggagact 44881 acctgtttta accaagaagt cttctctgta gtacctgatg tatttatata tgtggaacaa 44941 gaagtgtcac ccaactgcac agatgcttcc ttgttgagtt agcaggtaat ctagcattcc 45001 atgactggtt aaattaaagc agaaagtgta agttacccaa agaagctact cattgtgaag 45061 ttttaactac agcactatcc tgccaagtga aagaggtagg cacaagtaag ggaaaattaa 45121 aagggataag catcttatga tagggagtct tgttctgaca gtcttggagc tgtctacagc 45181 atgaagttga caacttcttg ttttggtttg tagttttatt gtctctagtt gtggcatcca 45241 gcattctggc gaactctcta tgtggcccac agtttaagca tgagattcat ctcttgaaat 45301 ttacactgag ttgctcagct tcagcttaca gagcttcagg aactgagtag ttcttggtct 45361 tcattggagt gttgtagcca gatattagtg aaagctaaaa gaattaagaa tccagctcag 45421 tctacaggta gataataaaa actcataaat attgaacagg gctacagtct aagaacagtt 45481 ttactatgct tttcttttga accatatgtt tttctttcta tagtcacctc catttctatc 45541 aaagacgatc atggtagacc aatttgttta caaaataagt ttggtctcaa acttggcctg 45601 attgattatt tacacagtac agcaagaata actacatagg tgactccttt caaatttgct 45661 ttgccaagcc tggcgaggta ttgcttgcct gtgagcccag ctacttggga ggctgaggtg 45721 agaggattgc ttgagcccag gaattcaagg ctgcagtgca ctatgattgt gcctgtgaat 45781 agccactgca ctatagcctg gacaacacag tgagaccatg tctccaaaaa ataattgctt 45841 tgatagaaat tttgacaagg aatctcagat tggacttttt aaaacgtctt gatgctatga 45901 agtcaaacca aggcagacat taggctttgc ctgatgtatc taatatcttg aagttactgg 45961 gcctcccagg aaggaacgac tttttattca ctcattgtaa ggctagcagc ccttgaagcc 46021 aggaattctg tgcacatttt caaatatgat attctattca aagccttgat aatataacca 46081 atgttttcca attgtattct atttaaaaga acagattcta ttgaactttc atgtaaataa 46141 tcatattgcc ataaaaataa gaatactcac aaagagtttc caaattctgg aaggatcagg 46201 tagagaggaa aagcaaatgt ttcaattttt gtttatgaaa gtatgcttaa caaggctggg 46261 tgcggtggct cacatctgta atcccagcac tttgggaagc caaggcggac aattgctttg 46321 agctcagagt ttgagaccag cctggcaaca tggcaaaacg ccgttactac aaaaaataca 46381 aaaaattagc tgggcatgga gcctgaggct gagaatcact tgagctgggg aagtggaggt 46441 agcagtgagc ccagatggtg ccactgcact ccaacctggg tgacagagtg agaccctgtc 46501 tcaaaaaata aaaaaaaagt atgcttaacc aagtggctgt aaactgcaga tagctttaaa 46561 gaaaaatttt ctttagatct ggaaaacaaa tattaaaaga accagcaatg tttcaaataa 46621 aaaagccata aaacctgtaa ttcttctcca tcagttcatt cagtctcatg taattaattc 46681 ttgctctgtt tgatcttggc tggtagttta attccaacga atggtatgaa ttcaaagtta 46741 ttagaaacct gtatttgtca gagttctttt cattcttccc atataactct ttgaagtcac 46801 agcactttag aattataatg gcttacaaag agctttcaga aaaagtatca gaacaaaaca 46861 attaactgtg gacaacaaga cttaaagtgg ctatatttaa agatctgatg tgagttaccc 46921 aattgacaag gatatttgga tatttctgtg gcacacaaca atttaaaata accaaaatta 46981 tgactggtag catttatacc aagacctatc acatttctag gaatgttata taattttgga 47041 acatattaat aacatatcta taaaaatata gcacaaagaa agttaaacat catttcttat 47101 tttaacagtg cttcccatat aatttaacct atcagataag gccatttggt ttaacatctc 47161 tcttttacag attctttaag aaattccagg gtcctctgga acatcccaaa gttagttcaa 47221 ggtcaaaaag acttaatttt gatttttgag aagtttgtca aataccaaag gtttaaaaca 47281 tttgatcaaa atcggatcat aggtcactat gaaataaaac caaagtgaaa aaagagttca 47341 aaggcaaaaa gcacaagaag agttatattg atgaaacatg aaatctctgt tttctaggcc 47401 agttacctgg aagagaaaat cctctcacaa ttttctatta agagtaaacc aatcctctga 47461 gaaaactcta ttgttccaac acataggccc acactttagc cttccatcag tgtactttaa 47521 tattaatgct caatttttag aaaaacttat aaataattcc cttctacttt tagccaactc 47581 aatcacataa aatttttcat gatatttatc ttctacaaac cttctacaac ttgcttaaac 47641 cttcatttgg tcctatactt ccttttttaa aattggcatt gtaccttagg acaaagattt 47701 acttttcttt tctccttatc attttgacca tataaggtta tctcctatac aaaagaaaaa 47761 attactctct tttcaatttt ctttatctct tcatacttgt aaatttcttc tcacatcttt 47821 cctacctagt ggttccttcc tgccttgttt tgatttcctt cataagtcca tatttagaaa 47881 caacctttaa ataacctctg attgccaagc tagagttaag ttttaaataa ataaataggc 47941 cggtcatggc ggctcacatc tgtaatccca gcactttggg aggcaaaggt cagaggatca 48001 cttcaggcca ggagtttgag accagcctga gcaacatggt gagaccccgt ctctattatt 48061 ttttttttaa aaaacaaaaa gcataaaaac tctgagaaca ttttgaaccc agaaagatat 48121 tacttccaat ttgtgccaca gagctggtaa tgtatggaaa tgtgtatctt gacagtgggt 48181 gggggtgggg tgaatattga caatgggggg atgttgttat gaggagagca aagctggaga 48241 ttacttagat tccttagaac aggaggactc tcaagggtgt gagtctctgt gtgtttcttt 48301 atgaatgtat gtgtgtagga aagtgctaag gcttaggttg aattctttag cagcagagcc 48361 caagatgggg attcttgcac aagcgattta ttgagaatac atctgaggaa atttatgaag 48421 cagtgagggg agcaggatag ggaaggggaa gaagctgatc aaagacatgg tttctgaagt 48481 ccagcgtaga tccctgattt cacagggagc accaccacag gaagagtacc agaaggttat 48541 gcctccttga ggcaagagga cctgctttct cccccagtaa tgagtcagtc agtggctgca 48601 ggccagccat gtgtggggat gaaacctccc agttctcttt atttacttat ttatttgaga 48661 cagggtcttg ctctgtcacc caggctggag tgcagtggtg caactgtggc tcactgcagc 48721 ctcaaactcc tgggctcaag tgatcctccc atctcagcct cctgagtagc tgagactata 48781 ggtgcacaac cacacctggc taatttttgt atttttttat aaagatgggg tttcaccata 48841 ttgcccagaa gttctgggtt caaagtgatc tgccctcctc ggcctctcaa agtgctggaa 48901 ttacagaccc agtcctcttt agatgacaca gctcccaacg ggcaagggaa agtctccaga 48961 gaagggcaca gctgtgaaac attggcagcc tggcccacag cagcaggagg atggatacac 49021 tggcttggcc aaagggacgt gatcgtccac aaggttgact acgaccagtt atgggataac 49081 cattctatat actactggaa aagaaactgt catttcaaat ctgggtcaca ttttggataa 49141 gagaaaaata aataaataaa aggaggagct acaaaaactt agtataggtt gatgctttaa 49201 aatttctttt cttagcbggg catggtaggg tgtgccctgt agtcctagct aattgggagg 49261 gtgaggtggg gggatcactt gaacttggga cgcggaggtt gcagtgagca atgatgccac 49321 tgcactccag cctgggcaat agaatgagac tctgtctcaa aaacaaacaa aaatttcttt 49381 tcctaggaac taacaaaaca ttgtgtcttt cttttgaaga ttatgtgata gaaaagctgg 49441 agcaatgcgg gttctttgac gacaacatta gaaaggacac attctttttg acggtccatg 49501 atgctatact ctatctacag aaccaagtga aatctcaaga gggtcaaggt tccattttag 49561 aaacggtaaa tattcaacct ttctacagat gtatcttttc taaactatca tgatttctat 49621 aaatggcaaa cattacacaa gtctagtcta gcbgttgaat tttaagctac ctatataact 49681 tcatggagcc tcagtttttt catcagtaaa atggaagtaa aaacattaac cttgctaggt 49741 agatatgaag actaaataag atagtttata ggaaattacc tggtagtacc cagtactgaa 49801 tagttctaca atgtgtaggt ttattaataa aagtgggcat tagctataat gccttttaag 49861 aatattgaat cttggatctt ttgtgatctg ggatttgtgt acataaattc cacttaaatt 49921 ctcagcaatc tggaaaacct tgaattataa atgtctttaa acaggatcca ccaggccata 49981 agtgatcttt gaaaaagaaa tttaaaaatc aagccacaaa gaagcccagg gttaattttt 50041 ccctacaaaa tagaataggc cctgatggga ggcctcatgg cacaacagta gcgcatctgg 50101 ctccagaata ggccctgatt tcccatgggt attattttgt taatttttct gtcaaatacc 50161 cagaagaggt gagcattctg gtctggttca ttgggcttgg cctaatggtg ctcctggtgg 50221 tacaagaatc tcatttctca tagtgaattt aggaaactaa agcaaatacc tatcaagata 50281 taataacagt aatgattcca gtgacatcgt ggatatttta aattgcttcc catttttcta 50341 aaagtagaat aagtagatcc ttattgtaga ttggcagttg attgaagaaa actaacttag 50401 gaaatgatat tatattattc tttttaggca ctggtagtgg agagattgtt ctatttgatg 50461 ttccttggta aaatactagt cctaactacc aagcbgtgga tcttaaatat aaaaaaggaa 50521 aaaaaaaaaa gagtaaagct acaaatctaa agaaaaaaaa actgtttatc attgaaaatt 50581 cataaacttt ttctatccaa cttaaaattc tctaacccat aggtgataag aaagttggat 50641 catatgaagt atcctttaag agatccacat taaaagtaaa acagaaccaa ggtatcaagt 50701 tctttctcaa catgaaagca gttattttat ttgtttatac ccattcttac taagatttta 50761 ggctatgaat gtcataaaaa ccactaacca agagtgtatc tactaggtta gactcactct 50821 tgtttgcaat cagagaggta ttgtgagtgg ctgggatgga tttttttgga ccttaaacaa 50881 atagactaag cataacggaa tgcttgtatt acatacttac tggtccacta aaagtgggtt 50941 ggacattcct ggtggcctgt gagatcaaga ggcttatatt tctgtgtctt ctcagagtct 51001 agcacaaagc tttatatgtg ataagtaggt gaatgatgat aaactccttc aagagggagt 51061 ccctctgtat caaagatatt gtgactgcaa tgacacaacc ttcttcctat ccctttattt 51121 taccatcaca ggactatctc aggacacaac ttgtagttag acttatcctc tacctttccc 51181 attatgtcat accatttgca cagggactta accctctaat tcattctcat actagctaag 51241 agaattgggc tatttgtgag ttgaaaagta gctaagtagc atttcaaaat gttattttag 51301 cctggatata tatttggagt tgctttgaaa atgtcctttt ccatgcaaaa cacaaagcca 51361 aaattgtcgt tggtttcctc tgtgtagaag attaaattac atgccacctc taaacagtag 51421 agcttttctg aataaccaac ttggtccata gacattggtt tccatctcca atagaattaa 51481 tttccaccca attccatttg tggctgtttt ttgtcatcag tgacaagctc ttcactgtgc 51541 attcattgca cactcaacgc tgtgctaagt gctcttagct tagccattga gagatgcact 51601 attgactgct gaatcattta ggcagagggg gtgacttgtt aagaggcata cactcaagag 51661 gttggggaag agagctgaaa aggagtttac acaatggaga actataccag ttcacctttc 51721 aatgtgcaaa aaaatgatat acaaaaaatt ttagttggga aatataaaag aacaatacag 51781 ctgaagagga ttctgaagta tgtaaagaca gatgagaagc accaggaaag cttcaaatca 51841 ttttcagtgg agcatcaggt gggttgatgc tattctattt ctaccctgtg ttctcttttt 51901 caagatcact ctcattcagg attgtaaaga tacccttgaa ttaatagaaa cagagctgac 51961 ggaagaagaa cttgatgtcc aggatgaggt atgatcattt tcttctgaag aaaatatttg 52021 aattacattt tgaataatta gagtaataca aatagtgaat atatctgatt aagaactgtc 52081 agggaacata attcccccaa atgcagaaaa gatggcttca tagcagggaa aaagagaaaa 52141 taagaattct cccttgaaga cattaagtac ttggggatct tttgtcccag gcatttgggg 52201 atgatcagca actggcaaga gccaacacac tgctcctgat ttgataccta cacctctgca 52261 tactgctctt ctagagatgt aaggccatgg ggtaggaaaa aaatgaatag aggaaacttc 52321 taagctagga actttataag cctcaggaat agtatgtgag gaacagaaac cctatgacct 52381 tccttcatat gactgataaa ggctttaaaa acacactctc cccaccctag actgattctg 52441 tgtatttcag atgctcttgt gacatcagac tattcctagg aaacttgtct gaacttgtag 52501 catctgagta aattttgcag cttcgccact ggataagagg tgaacactga aggaagatca 52561 cagaattgta aaaagttgaa agatttctta gaatcaagta gtctaacatt ctagcccatg 52621 cagaaatcct tcctacacca tccttgatga atgttcattc agcttttatg tgaacatttc 52681 cagacattgg ccactagcgg cttctcaagg gagtttgtta catggttgga agtctctaaa 52741 tgttacttgt gcttacagaa ctcaatttgg cctttctgta gtaaccacct agtgaactga 52801 gatctgcctt ccttagcaac acagaccttc ccactgaaca gcccttcaaa tatttgagaa 52861 tagttctcat gtctccagca gactctcttc cagttgagac tcttctagtt ccttctattc 52921 cttacaaaca agcagtcagt gcttctctgg tcacgatggg gacacaaaac cctaaatgcg 52981 gccaggccag catggagatt attcaaccat gacctacctt gatctcatca agatattcct 53041 attactacag cttaaaaatg tgtttccttt cataatagca acatcagaat tttagcttct 53101 attgagcagg ggccaactaa agactggggc attttcatac aagctatggt ctagtagagt 53161 tccctagtta tatttattta attgagcttt gaccctaata cagaactaca cctatttctg 53221 ctggatttca tcttgttggt tcttgtttac tgacataatt ttgtattatt attagtatta 53281 ttattattat tattatttgt gactgagtct tactctgtca cctggactgg agtgcagtgg 53341 tacaatctca gctcactgca atccctccct cccaggttca agagattctc acgtgtgcct 53401 cagcttccca agtagttggg attacaggcg ctcgccacca cgtccagata attttttttt 53461 tttgtattct tagtagagac agggttttgc catgttgtcc aggctggtct tgaactcctg 53521 acctcaagta atccacctgc cttgccctcc cagattgctg ggattacagg catgagccac 53581 cacattggcc agttttgtgt tttgaatcta acatccagga tattgtctac cccagtaccc 53641 gttacctggt gtcataatca aatctgataa gcctgccttc tctgcctttt tctaggtctt 53701 gaaaaaatgt tgcaaagaaa acattcaacc ccctatagtg aaatcaggca gtaaggatga 53761 caggcagaga tttctgtgga ggaaatacat tgctagagtg aaaatcacag tacctgcatc 53821 ttggcccacc agcttagtga gcccaggaaa gtcattatcg acctgagaag tccttttagc 53881 tccagtagtt tatgactcta tggatatagg gtgccttagt ttgagtaaaa actcatatgt 53941 caacattaaa acttaagact gctatattat aggatattta ttggttgcca cgtaaaataa 54001 tcattcaggg agggtttcta tagatggtaa aacaatatag cacaatagtt tcaagggcat 54061 ggactttaga acaagacaga cctgggtgct agtcctcatt ctgctactta ctggctgtgc 54121 accccagggc aaattactta tcctgtcttc atattagtat cttcatgtaa agtagtaata 54181 ataccacaga gttgtgaaaa ttaaaggata aatgtaaagt aacaagagca gtgccttgta 54241 catagtaagt gctcaataaa tagtaatcat tgctcttaaa taaatccaat taaagtgtga 54301 tgaatacagg ccaggctcag tgactcaagc ctgtaatccc agcactttgg gaggctgagg 54361 cagggggatc acttgaggtc aggagtttga gaccagcctg actaacatgg taaccccccg 54421 accatctcta ctaaaaaaaa aaaaaaaaaa attagcbggg tgtggtggca ggcacctgta 54481 atcccagcta ctcgggaggc tgaggcagga gaattgcttg aacctgggag gcagaggttg 54541 cagtgagctg agatcacgcc acagcactcc agcctgggca acagtgagtg agattcagtc 54601 tccaaaaaaa aaaaaaagta taatgaatac gaaatgaagt ttttacccta tttctattgt 54661 gatgatatac acctaagatg agtagcagta agcaatcaat actataaaaa catatttata 54721 aaaaagataa tgcagactta aggagaattc agttgtatca acactttgtt ttccccttgc 54781 ttccacaggc tatgcgtaca cttgcatcct gaaagtgggt tcgggaggtc tctatgagca 54841 aggaatacaa gacaaaactt cctcaatgca ttgactattt cttcagactc aaaacactca 54901 ttcttttttc tattaagcca ttgaaagaga agcactaaga ctgcttctag gctttattta 54961 taaaataaac accttatccc taacatgggc aaaatggcta gaattattca gacgatttgg 55021 cagcgtccag ggtaagctgg tgttataata cgctgctgat ctacatcaca gatttgctaa 55081 taatgttcac gtgggccctg gcatatctct gttcagttag agtgagtgct gacccaacag 55141 cctctgtggt caagcgagtc acgaatgatt aatcataaag aaaaatcagt ttttgactga 55201 cctggatatc catgagctgc actgatcacc atgtaaggtc acatttagta aatgctgaaa 55261 taaaatgatt aatgcattta tcaataaaag cctttgaaaa tactttggat aataaattgg 55321 agttttaaaa atgcaaattt gcttagtatc taataatgaa gtgttattac atatagccgg 55381 aattgaggat ctctttgatc ctggaaatgg tttacctaaa agctacagaa ccaggccaat 55441 atattttgaa atattgatgc agacaaatga aataataaag agattttcat ggtttataaa 55501 aatctttttt gatatgataa taatcatgat cacaactgag atcaaaaaaa tatatgacag 55561 attattttgt ttaaaaatgc agttttaatt atcttagtct atagaaatga tcattgcatg 55621 gaggcatgta taggtatgat ctgtgtaaaa tctgacataa aaacagtgct attctgagtg 55681 aaaatttttt tgatgtgctt acataaccat ggtgattaaa atgagtttat attttttctc 55741 aaaaatttta gcagtgtgta aagtaagtaa tctttaactg aactctgacc acttaaaaaa 55801 aaatctaaaa attgaactac ctatagtagt ctgtgtttaa agtgaatttt taaagacaaa 55861 gcattctaaa tgaactcaat ataaaaacat tcatttggaa tgtacatact gaaaaataca 55921 ggtttttttg accaaaagtt tttatatctt ttctttttat ttattttttt cctaagtgcc 55981 aacaattttc tagatattat atacaacaca ggctttgatc ttggggactt ttcccatata 56041 tttcacactg gagtgaatga agttgtactt catttctaga gaaaagttat acccaggtcc 56101 ccaattgaga atgtcttgct tgattgaaaa cgacatcatc ccttggtata ctccagggat 56161 tggtttcagg acccctgcat ttaccaaaat ttgtgcacac tcaagtcctg cagtcacccc 56221 tgcctaaaga tagaatggct tctctgtttt tcttctgaaa tacaaccaga aacaatgtgt 56281 ctatttctga aagaatagga ttaatgatca tacaaatggg ttaatcctga attctggttg 56341 taaatctggt tacagcataa ctaggattat aatgctgcct cattttcaca gcactacttg 56401 cttatattga caacaaatca tctcgctaaa gagtgaatgt aggccaggcg cggtggctca 56461 tgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcacgaggt caggagatcg 56521 agaccatcct ggctaacatg gtaaaacccc gtctctacta aaaatagaaa aaaagaaatt 56581 agcctagcgt ggtggctggc gggcgcctgt agtcccagct atttgggagg ctaaggcagg 56641 agaatggcgt gaacccggga ggcggagctt gcagtgagcc gaggtcgtgc cactgcactc 56701 cagcctgggc gacagagcaa gactccgtct caaaaaaaaa aaaaaaaaaa aaaaaagagt 56761 gaatgtaata gtcttgcaga aaatgaatga atacctttgt tcaataaagg aaatatgcac 56821 tgctcacttt tttgaaggaa atgccaaagt tacgttttac aacaaggcta gagtttgtaa 56881 attctgggtt catttgtgat gacataagtc agcaaactgc gggaatactg tctcttctat 56941 gtattttgtg aatagtaagc ataattttag ttttgtatta tcaatgaaaa tttcacttga 57001 aattaaagct gccttttgtt atatttttaa cctataggat aagattccag tattgtatat 57061 gagttttaac aaattaaaaa atcaaatcat gtacatttga aaatatttgc acacatttaa 57121 aaataaatgt aaagttgtct tttaaactac tcggatgtgt cctttctgaa caaaa

Otoferlin

[0122] To date, several hundred mutations in the human OTOF gene have been identified to cause profound prelingual deafness DFNB9. Such mutations are the cause of deafness in 2-8% of people that are born with an autosomal, recessively inherited, non-syndromic deafness in different populations (Rodriguez-Ballesteros et al. (2008) Hum. Mutat. 29 823-831; Choi et al. (2009) Clinical Genetics 75 237-243; Duman et al. (2011) Genet Test Mol Biomarkers 15 29-33; Varga et al. (2006) J Med Genet 43 576-581; Iwasa et al. (2013) BMC Med. Genet. 14 95). For example, two substitutions in exon 15 at positions 490 and 515 in the conserved C2C domain of otoferlin cause DFNB9 (Mirqhomizadeh et al. (2002) Neurobiol. Dis. 10(2): 157-164). Migliosi et al. found a novel mutation Q829X in OTOF in Spanish patients with prelingual non-syndromic hearing loss (Migliosi et al. (2002) J. Med. Genet. 39(7): 502-506).

[0123] Additional exemplary mutations in a otoferlin gene detected in subjects having hearing loss and methods of sequencing a nucleic acid encoding otoferlin are described in, e.g., Rodriguez-Ballesteros et al. (2003) Hum Mutat. 22: 451-456; Wang et al. (2010) BMC Med Genet. 11:79; Yildirim-Baylan et al. (2014) hit. J. Pediatr. Otorhinolaryngol 78: 950-953; Choi et al. (2009) Clin. Genet. 75(3): 237-243; and Marlin et al. (2010) Biochem Biophys Res Commun 394: 737-742.

[0124] Otoacoustic emissions from DFNB9 patients are normal, at least for the first decade of life, indicating morphological integrity of the inner ear and proper function of outer hair cells. Apart from the lack of synaptic transmission and the subsequent loss of synapses, the morphology and physiology of the inner ear remains preserved in DFNB9, at least during the first decade in life in humans.

[0125] Studies in mouse models revealed that synapses are structurally normal, and IHCs preserve normal synapse numbers in mice within the first postnatal week. Between P6 and P15, about half of the synapses get lost (Roux et al. (2006) Cell 127 277-289). Animal models allowed studying the effect of mutations in otoferlin on synaptic transmission by recording the change in plasma membrane capacitance after vesicle fusion and the activity in the auditory nerve. In otoferlin knock-out (Otof−/−) mice, almost no exocytosis could be triggered in IHCs by depolarization induced Ca2+ influx through voltage gated Ca2+ channels (Roux et al. (2006) Cell 127 277-289). In profoundly hearing impaired pachanga (Oto.sup.Pga/Pga) mice with a random point mutation in the C2F domain, short (<10 ms) depolarizations of the IHCs elicited vesicle fusion of similar size as in wild type mice, however sustained stimulations uncovered a strong deficiency in replenishing vesicles to the readily releasable pool (Pangrsic et al. (2010) Nat. Neurosci. 13 869-876). The p.Ile515Thr mutation, found in human patients with only mildly elevated hearing thresholds but a severe reduction in speech understanding and a temperature-dependent deafening (Varga et al. (2006) J Med Genet 43 576-581), uncovered an intermediate phenotype when studied in a mouse model (Strenzke et al. (2016) EMBO J. 35:2519-2535). These OtofI515T/I515T mice showed a moderate elevation of hearing thresholds when assessed by ABR with a reduction in wave I amplitude, but normal auditory thresholds in behavioral tests and recordings of single auditory nerve units. Exocytosis of the RRP is again intact, but sustained exocytosis is reduced, although not as severe as in OtofPga/Pga. While in wild type mice at room temperature, during a sustained stimulus 750 vesicles can fuse per second at each active zone, this rate drops to 350 vesicles/s/active zone in OtofI515T/I515T mice and to 200 vesicles/s/active zone in OtofPga/Pga IHCs (Pangrsic et al. (2010) Nat. Neurosci. 13 869-876; Strenzke et al. (2016) EMBO J. 35 2519-2535). This correlated with lower otoferlin protein levels at the plasma membrane of IHCs, indicating that the amount of otoferlin scales with exocytosis and hearing (Strenzke et al. (2016) EMBO J. 35 2519-2535).

[0126] Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

[0127] The OTOF gene encodes otoferlin, a protein that is involved in synaptic vesicle exocytosis in cochlear hair cells (see, e.g., Johnson and Chapman (2010) J. Cell Biol. 191(1):187-198; and Heidrych et al. (2008) Hum. Mol. Genet. 17:3814-3821).

[0128] The human OTOF gene is located on chromosome 2p23.3. It contains 48 exons encompassing ˜132 kilobases (kb) (NCBI Accession No. NG009937.1). The mRNA encoding the long-form of otoferlin expressed in the brain includes 48 exons (Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000). Forward and reverse primers that can be used to amplify each of the 48 exons in the OTOF gene are described in Table 2 of Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000. In some examples, the full-length OTOF protein is a full-length wildtype OTOF protein. The full-length wildtype OTOF protein expressed from the human OTOF gene is 1997 residues in length.

[0129] An exemplary human wildtype otoferlin protein is or includes the sequence of any one of SEQ ID NOs: 8-12. Isoform e of human otoferlin protein (SEQ ID NO: 12) is encoded by an mRNA that includes exon 48 and does not include exon 47 of the otoferlin gene (Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000). In some embodiments, the active otoferlin protein has the sequence of SEQ ID NO: 12, but is missing the 20 amino acids including the RXR motif identified in Strenzke et al., EMBO J. 35(23):2499-2615, 2016). Non-limiting examples of nucleic acids encoding a wildtype otoferlin protein are or include any one of SEQ ID NO: 13-17. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 13-17 can be codon-optimized to allow for optimal expression in a non-human mammal or in a human. Orthologs of human otoferlin proteins are known in the art.

TABLE-US-00005 Human canonical (long) isoform sequence (otoferlin protein) (also called otoferlin isoform a) (NCBI Accession No. AAD26117.1) (SEQ ID NO: 8) MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKR HTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTL FLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPI IVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDPLAAFELLQIGPAGK ADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIH NYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTT GEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFAS IDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKID ELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIE ASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRL CKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRP LLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIF VRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQI WDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFEL TGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLL LLLLLALFLYSVPGYLVKKILGA Human Isoform 2 (short 1) (otoferlin protein) (also called otoferlin isoform d) (NCBI Accession No. NP_919304.1) (SEQ ID NO: 9) MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKR HTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTL FLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPI IVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK ADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIH NYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTT GEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFAS IDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKID ELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIE ASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRL CKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRP LLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIF VRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQI WDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFEL TGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALL GLLMLGLFLYSLPGYMVKKLLGA Human Isoform 3 (short 2) (otoferlin protein) (also called otoferlin isoform c) (NCBI Accession No. NP_919303.1) (SEQ ID NO: 10) MMTDTQDGPSESSQIMRSLTPLINREEAFGEAGEAGLWPSITHTPDSQEEGLNDIQEMIKTEKSYPERRLR GVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFL QKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAG WTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFA ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVETNLELYGEAHELRDDPPIIVIEIYDQDSMGKA DFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDR GPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKW FEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVALLARCRVLCNGG SSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWW SKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK KKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSRE AGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPS QILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEVALLALRHWEDIPRAGCRLVPE HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPA RLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNE NDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLK LLLLLLLLLLLALFLYSVPGYLVKKILGA Human Isoform 4 (short 3) (otoferlin protein) (also called otoferlin isoform b) (NCBI Accession No. NP_004793.2) (SEQ ID NO: 11) MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKR HTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTL FLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPI IVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK ADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIH NYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTT GEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFAS IDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKID ELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIE ASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRL CKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRP LLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIF VRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQI WDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFEL TGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLL LLLLLALFLYSVPGYLVKKILGA Human Isoform 5 (short 4) (otoferlin protein) (also called otoferlin isoform e) (NCBI Accession No. NP_001274418.1) (SEQ ID NO: 12) MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSK VFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEE EKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLG DGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKK YTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHK WAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRA EGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKV QIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRAR LLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGN YGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKP CIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKD QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRK EFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQ CTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYC PPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVE VLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVV DCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIK KLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPS GIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFD NFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPIN VLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVY DWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPP GRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRL ELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQD TDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGA IELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAE EAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPG YMVKKLLGA Complete cds (otoferlin cDNA) (encodes the protein of SEQ ID NO: 8) (SEQ ID NO: 13) atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca ggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgct gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcct ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct tcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacccgc tggcggcctt cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact gccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa tgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctgg ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca tcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaacta catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga ttgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactggga ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact tcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaagga gtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat ctgggatgcg gaccacttct ccgctgacga cttcctgggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaa agacagccaa gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctga ccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga accctctcaa gtcggctcgc tacttcttgt ggcacacgta tcgctggctg ctcctcaaac tgttgctgct cctgctgctg ctcctcctcc tcgccctgtt cctctactct gtgcctggct acctggtcaa gaaaatcctc ggggcctga Human Otoferlin Transcript Variant 1 (encodes the protein of SEQ ID NO: 8) (SEQ ID NO: 14) atggccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgcc aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat cgggaccttc cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc tcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccgg cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc cgactcggtg tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc taagccagac attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtgga ggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttc gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtg attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat cctgtctgac cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc caatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgct ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca gatccgagac tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt agacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggag agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg caactatggg aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg gccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggc ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc tgacaaggac cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa gcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaag gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt gctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaa gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa gatggcagac gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct gttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgag tgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa ccccaacttc aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct gcacccgccc ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa gaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggag gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac catgaaggag caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga gtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggat ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta cggcatgttc cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac ggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggag aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg cctctgcaaa gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg catcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcct ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag tgacatcttc gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt ctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagcc aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa cgatgagttt gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa ccggcccgac acgagcttca tctggttcct gaaccctctc aagtcggctc gctacttctt gtggcacacg tatcgctggc tgctcctcaa actgttgctg ctcctgctgc tgctcctcct cctcgccctg ttcctctact ctgtgcctgg ctacctggtc aagaaaatcc tcggggcctg a Human Otoferlin Transcript Variant 2 (encodes the protein of SEQ ID NO: 11)  (SEQ ID NO: 15) atgatcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca ggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgct gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcct ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct tcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggcctt cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact gccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa tgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctgg ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca tcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaacta catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga ttgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactggga ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact tcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaagga gtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat ctgggatgcg gaccacttct ccgctgacga cttcctgggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaa agacagccaa gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctga ccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga accctctcaa gtcggctcgc tacttcttgt ggcacacgta tcgctggctg ctcctcaaac tgttgctgct cctgctgctg ctcctcctcc tcgccctgtt cctctactct gtgcctggct acctggtcaa gaaaatcctc ggggcctga Human Otoferlin Transcript Variant 3 (encodes the protein of SEQ ID NO: 8) (SEQ ID NO: 16) atgatgaccga tactcaggat ggccctagcg agagctccca gatcatgagg tccctcactc ccctgatcaa cagggaggag gcatttgggg aggctgggga ggcggggctg tggcccagca tcacccacac tcctgattca caggaagaag gcctgaacga catacaggag atgatcaaaa cggagaagtc ctaccctgag cgtcgcctgc ggggcgtcct ggaggagctg agctgtggct gctgccgctt cctctccctc gctgacaagg accagggcca ctcatcccgc accaggcttg accgggagcg cctcaagtcc tgcatgaggg agctggaaaa catggggcag caggccagga tgctgcgggc ccaggtgaag cggcacacgg tgcgggacaa gctgaggctg tgccagaact tcctgcagaa gctgcgcttc ctggcggacg agccccagca cagcattccc gacatcttca tctggatgat gagcaacaac aagcgtgtcg cctatgcccg tgtgccctcc aaggacctgc tcttctccat cgtggaggag gagactggca aggactgcgc caaggtcaag acgctcttcc ttaagctgcc agggaagcgg ggcttcggct cggcaggctg gacagtgcag gccaaggtgg agctgtacct gtggctgggc ctcagcaaac agcgcaagga gttcctgtgc ggcctgccct gtggcttcca ggaggtcaag gcagcccagg gcctgggcct gcatgccttc ccacccgtca gcctggtcta caccaagaag caggcgttcc agctccgagc gcacatgtac caggcccgca gcctctttgc cgccgacagc agcggactct cagacccctt tgcccgcgtc ttcttcatca atcagagtca gtgcacagag gtgctgaatg agaccctgtg tcccacctgg gaccagatgc tggtgttcga caacctggag ctctatggtg aagctcatga gctgagggac gatccgccca tcattgtcat tgaaatctat gaccaggatt ccatgggcaa agctgacttc atgggccgga ccttcgccaa acccctggtg aagatggcag acgaggcgta ctgcccaccc cgcttcccac ctcagctcga gtactaccag atctaccgtg gcaacgccac agctggagac ctgctggcgg ccttcgagct gctgcagatt ggaccagcag ggaaggctga cctgcccccc atcaatggcc cggtggacgt ggaccgaggt cccatcatgc ccgtgcccat gggcatccgg cccgtgctca gcaagtaccg agtggaggtg ctgttctggg gcctacggga cctaaagcgg gtgaacctgg cccaggtgga ccggccacgg gtggacatcg agtgtgcagg gaagggggtg cagtcgtccc tgatccacaa ttataagaag aaccccaact tcaacaccct cgtcaagtgg tttgaagtgg acctcccaga gaacgagctg ctgcacccgc ccttgaacat ccgtgtggtg gactgccggg ccttcggtcg ctacacactg gtgggctccc atgccgtcag ctccctgcga cgcttcatct accggccccc agaccgctcg gcccccagct ggaacaccac ggtcaggctt ctccggcgct gccgtgtgct gtgcaatggg ggctcctcct ctcactccac aggggaggtt gtggtgacta tggagccaga ggtacccatc aagaaactgg agaccatggt gaagctggac gcgacttctg aagctgttgt caaggtggat gtggctgagg aggagaagga gaagaagaag aagaagaagg gcactgcgga ggagccagag gaggaggagc cagacgagag catgctggac tggtggtcca agtactttgc ctccattgac accatgaagg agcaacttcg acaacaagag ccctctggaa ttgacttgga ggagaaggag gaagtggaca ataccgaggg cctgaagggg tcaatgaagg gcaaggagaa ggcaagggct gccaaagagg agaagaagaa gaaaactcag agctctggct ctggccaggg gtccgaggcc cccgagaaga agaaacccaa gattgatgag cttaaggtat accccaaaga gctggagtcc gagtttgata actttgagga ctggctgcac actttcaact tgcttcgggg caagaccggg gatgatgagg atggctccac cgaggaggag cgcattgtgg gacgcttcaa gggctccctc tgcgtgtaca aagtgccact cccagaggac gtgtcccggg aagccggcta cgactccacc tacggcatgt tccagggcat cccgagcaat gaccccatca atgtgctggt ccgagtctat gtggtccggg ccacggacct gcaccctgct gacatcaacg gcaaagctga cccctacatc gccatccggc taggcaagac tgacatccgc gacaaggaga actacatctc caagcagctc aaccctgtct ttgggaagtc ctttgacatc gaggcctcct tccccatgga atccatgctg acggtggctg tgtatgactg ggacctggtg ggcactgatg acctcattgg ggaaaccaag atcgacctgg agaaccgctt ctacagcaag caccgcgcca cctgcggcat cgcccagacc tactccacac atggctacaa tatctggcgg gaccccatga agcccagcca gatcctgacc cgcctctgca aagacggcaa agtggacggc ccccactttg ggccccctgg gagagtgaag gtggccaacc gcgtcttcac tgggccctct gagattgagg acgagaacgg tcagaggaag cccacagacg agcatgtggc gctgttggcc ctgaggcact gggaggacat cccccgcgca ggctgccgcc tggtgccaga gcatgtggag acgaggccgc tgctcaaccc cgacaagccg ggcatcgagc agggccgcct ggagctgtgg gtggacatgt tccccatgga catgccagcc cctgggacgc ctctggacat ctcacctcgg aagcccaaga agtacgagct gcgggtcatc atctggaaca cagatgaggt ggtcttggag gacgacgact tcttcacagg ggagaagtcc agtgacatct tcgtgagggg gtggctgaag ggccagcagg aggacaagca ggacacagac gtccactacc actccctcac tggcgagggc aacttcaact ggcgctacct gttccccttc gactacctgg cggcggagga gaagatcgtc atctccaaga aggagtccat gttctcctgg gacgagaccg agtacaagat ccccgcgcgg ctcaccctgc agatctggga tgcggaccac ttctccgctg acgacttcct gggggccatc gagctggacc tgaaccggtt cccgcggggc gcaaagacag ccaagcagtg caccatggag atggccaccg gggaggtgga cgtgcccctc gtgtccatct tcaagcaaaa gcgcgtcaaa ggctggtggc ccctcctggc ccgcaatgag aacgatgagt ttgagctcac gggcaaggtg gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagt gggcctggcc cgcaatgaac ctgaccccct agagaaaccc aaccggcccg acacgagctt catctggttc ctgaaccctc tcaagtcggc tcgctacttc ttgtggcaca cgtatcgctg gctgctcctc aaactgttgc tgctcctgct gctgctcctc ctcctcgccc tgttcctcta ctctgtgcct ggctacctgg tcaagaaaat cctcggggcc tga Human Otoferlin Transcript Variant 4 (encodes the protein of SEQ ID NO: 9) (SEQ ID NO: 17) atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca ggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgct gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcct ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct tcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggcctt cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact gccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa tgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctgg ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca tcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaacta catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga ttgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactggga ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact tcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaagga cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctga ccccctagag aaacccaacc ggcccgacac ggccttcgtc tggttcctca accctctcaa gtccatcaag tacctcatct gcacccggta caagtggctc atcatcaaga tcgtgctggc gctgttgggg ctgctcatgt tggggctctt cctctacagc ctccctggct acatggtcaa aaagctcctt ggggcatga Human Otoferlin Transcript Variant 5 (encodes the protein of SEQ ID NO: 12) (SEQ ID NO: 18) atg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgcc aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat cgggaccttc cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc tcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccgg cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc cgactcggtg tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc taagccagac attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcttgga ggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttc gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtg attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat cctgtctgac cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc caatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgct ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca gatccgagac tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt agacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggag agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg caactatggg aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg gccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggc ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc tgacaaggac cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa gcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaag gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt gctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaa gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa gatggcagac gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct gttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgag tgtgcaggga agggggtgca gtcttccctg atccacaatt ataagaagaa ccccaacttc aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct gcacccgccc ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa gaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggag gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac catgaaggag caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga gtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggat ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta cggcatgttc cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac ggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggag aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg cctctgcaaa gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg catcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcct ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag tgacatcttc gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt ctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagcc aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa cgatgagttt gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa ccggcccgac acggccttcg tctggttcct caaccctctc aagtccatca agtacctcat ctgcacccgg tacaagtggc tcatcatcaa gatcgtgctg gcgctgttgg ggctgctcat gttggggctc ttcctctaca gcctccctgg ctacatggtc aaaaagctcc ttggggcatg a

[0130] A non-limiting example of a human wildtype otoferlin genomic DNA sequence is SEQ ID NO: 19. The exons in SEQ ID NO: 19 are: nucleotide positions 5001-5206 (exon 1), nucleotide positions 25925-25983 (exon 2), nucleotide positions 35779-35867 (exon 3), nucleotide positions 44590-44689 (exon 4), nucleotide positions 47100-47281 (exon 5), nucleotide positions 59854-59927 (exon 6), nucleotide positions 61273-61399 (exon 7), nucleotide positions 61891-61945 (exon 8), nucleotide positions 68626-68757 (exon 9), nucleotide positions 73959-74021 (exon 10), nucleotide positions 74404-74488 (exon 11), nucleotide positions 79066-79225 (exon 12), nucleotide positions 80051-80237 (exon 13), nucleotide positions 81107-81293 (exon 14), nucleotide positions 82690-82913 (exon 15), nucleotide positions 83388-83496 (exon 16), nucleotide positions 84046-84226 (exon 17), nucleotide positions 84315-84435 (exon 18), nucleotide positions 85950-86050 (exon 19), nucleotide positions 86193-86283 (exon 20), nucleotide positions 86411-86527 (exon 21), nucleotide positions 86656-86808 (exon 22), nucleotide positions 87382-87571 (exon 23), nucleotide positions 87661-87785 (exon 24), nucleotide positions 88206-88340 (exon 25), nucleotide positions 89025-89186 (exon 26), nucleotide positions 89589-89708 (exon 27), nucleotide positions 90132-90293 (exon 28), nucleotide positions 90405-90567 (exon 29), nucleotide positions 91050-91180 (exon 30), nucleotide positions 92549-92578 (exon 31), nucleotide positions 92978-93106 (exon 32), nucleotide positions 95225-95291 (exon 33), nucleotide positions 96198-96334 (exon 34), nucleotide positions 96466-96600 (exon 35), nucleotide positions 96848-96985 (exon 36), nucleotide positions 97623-97750 (exon 37), nucleotide positions 97857-98027 (exon 38), nucleotide positions 98670-98830 (exon 39), nucleotide positions 99593-99735 (exon 40), nucleotide positions 100128-100216 (exon 41), nucleotide positions 101518-101616 (exon 42), nucleotide positions 101762-102003 (exon 43), nucleotide positions 102669-102847 (exon 44), nucleotide positions 102952-103052 (exon 45), nucleotide positions 103494-103691 (exon 46), nucleotide positions 105479-106496 (exon 47), and exon 48 (the sequence starting with CCGGCCCGAC (SEQ ID NO: 89); see also the description of this exon in Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000).

[0131] The introns are located between each contiguous pair of exons in SEQ ID NO: 19, i.e., at nucleotide positions 100-5001 (intron 1), nucleotide 5207-25924 (intron 2), nucleotide positions 25984-35778 (intron 3), nucleotide positions 35868-44589 (intron 4), nucleotide positions 44690-47099 (intron 5), nucleotide positions 47282-59853 (intron 6), nucleotide positions 59928-61272 (intron 7), nucleotide positions 61400-61890 (intron 8), nucleotide positions 61946-68625 (intron 9), nucleotide positions 68758-73958 (intron 10), nucleotide positions 74022-74403 (intron 11), nucleotide positions 74489-79065 (intron 12), nucleotide positions 79226-80050 (intron 13), nucleotide positions 80238-81106 (intron 14), nucleotide positions 81294-82689 (intron 15), nucleotide positions 82914-83387 (intron 16), nucleotide positions 83497-84045 (intron 17), nucleotide positions 84227-84314 (intron 18), nucleotide positions 84436-85949 (intron 19), nucleotide positions 86051-86192 (intron 20), nucleotide positions 86284-86410 (intron 21), nucleotide positions 86528-86655 (intron 22), nucleotide positions 86809-87381 (intron 23), nucleotide positions 87572-87660 (intron 24), nucleotide positions 87786-88205 (intron 25), nucleotide positions 88341-89024 (intron 26), nucleotide positions 89187-89588 (intron 27), nucleotide positions 89709-90131 (intron 28), nucleotide positions 90294-90404 (intron 29), nucleotide positions 90568-91049 (intron 30), nucleotide positions 91181-92548 (intron 31), nucleotide positions 92579-92977 (intron 32), nucleotide positions 93107-95224 (intron 33), nucleotide positions 95292-96197 (intron 34), nucleotide positions 96335-96465 (intron 35), nucleotide positions 96601-96847 (intron 36), nucleotide positions 96986-97622 (intron 37), nucleotide positions 97751-97856 (intron 38), nucleotide positions 98028-98669 (intron 39), nucleotide positions 98831-99592 (intron 40), nucleotide positions 99736-100127 (intron 41), nucleotide positions 100217-101517 (intron 42), nucleotide positions 101617-101761 (intron 43), nucleotide positions 102004-102668 (intron 44), nucleotide positions 102848-102951 (intron 45), nucleotide positions 103053-103494 (intron 46), nucleotide positions 103692-105478 (intron 47), and nucleotide positions 106497-108496 (intron 48).

TABLE-US-00006 Human Otoferlin Gene Sequence (NCBI Accession No. NG_009937.1) (SEQ ID NO: 19) 1 gggagagcat gcgggctttt tcacccattt ggagactctg cctgcagaat cctcaagaca 61 ttcatttcat tcattcgttc actctttttt tcagacaagg gttcttagga tcattcattc 121 attctataca gatttgctga tactgtacag gttgcctctc agaatccagt gcctgttctc 181 agtacctatg ctgactggta ggagggataa agacagcctt acaccctggg agaggcggtc 241 cagagtagaa acatcagaca ctgtaggaga aagagccaaa gaacaggagg caacagccag 301 acttgcatgt tagatggttg gagtctgaaa atatccagag taaagaaagg taggtgtaac 361 ctagtatttg aaagtgctaa acagcaagcc agcgctcagg gcaagtggcc aggaagcttt 421 ccaagaaaaa cttctgggag gataaaggga ggtctgtgaa aggaccgacc gcaaagtcgg 481 gcgggtactg cacacatgac ccattaacta cggctcttcc ggccttgcca ggttcttcga 541 gcgggcaccc acccggtatc cttccctcct tcaaccaaca agtactgacc ttgcccgaat 601 gctgggtgct ggccctgtgc gccggacgga agggcctgat tttctcgcat tttctctaag 661 cgctggaggc tgcccgcctg gggcgtctcc aagcactaaa ccccacgtgg ctccatctcc 721 tcccccttcc ccggctacat ccatgcgagg tcccttatgc cctgctggct gtgccccact 781 tgccagggag cgccttcctg tgaaggggaa tctggggagg cccccgcccg tgcctgccca 841 cttcctactc tgaaaccaca aacctctagg aaggcccctc gccccgtcgg gtggaaaatt 901 ggctcctcgg ggttccttca accccaaagt ccgggggcag ggggctgaat ttcgatcacc 961 gaggagggcg ctagtggaag ggggagggga ggaggcgctc cctcggcctt acccgggcat 1021 gagtccaggg ggcacgtagg cggcattgaa ctcggtcagt agggtgcccg cgctgcggga 1081 ggccatggtg ggtgcgcgag tacagcgagc ctggcgctcc gctccgcccc acggtaaaca 1141 gcggcgggtc acctggcaac ggccacggcg gcgagcctgg caacgccagc tggccccgcg 1201 gtcctcgcgt tccgagacac tgcgcccccc tggcggccac ctcccggagc agccccatag 1261 ggcgcgccca gaaggcgcct cccatttccg cgagctctgc tgggtgaccc ctgtcacttg 1321 ccccggcgcg tcggggctct ctgccttgct gcctgcggga tgtgcagagg ctcagatgcg 1381 ggagggaggc agaacatcgc tggagaggcc tggcgggatc cgtcttgcgg tgacccggct 1441 tggaacgcga cgctaccaca aaggacaggc caggtcctga ctttggaggt cacgcacgaa 1501 gcagctgccc caccgtggct caggcccaga aacctgagtg gccttagggt ccccaggagc 1561 tatgtctctc caaggcttcc cctgcacccc agctccatgg gagttccagg aaggggctct 1621 gtagtgggcc gcgctgggcg aggttgccta ggacgctgtg tgtaattgtg tgtgtgcgtg 1681 cgtgcgtgca tgtgtgcgtg tgtgtgtgcg cgccttgcga agaggagcat ttttcatttt 1741 tcttcttaat ctctagctga tggcttcctt ctcacctcat catacctgta aactactcca 1801 caagaggcaa aaagaaaatc atagaacgtc tgggtgtgtg atttacattt gtccccaatg 1861 ctgccgttca ttttggggat ggcatccgca ggggtagcgc ttgccccaga gagcaggcct 1921 gctgaaggcc caccccctgt gtaatcctcc ctgtgactgc ttcagcctcc acatttgagt 1981 ttctccaggg acccttacac cagccttggt gcctagggca ggcacagggc cttcggcttt 2041 tccataaggg gtgagggtat ggggacagct tccacggtgc caggctcttg gtgactcggg 2101 tggaggccct gccaccccag ctccctctgc agcagtcctg gtgtcatgaa gaagcctggc 2161 agttcccact ttgtctccag gtcttgcttc ttcccttcag atgccggatg gagagcagtg 2221 ctcccctcgc acttcggttc tgtaaatggc agtggatgaa gaccgcagac gctactgggt 2281 tcacagaatg tggctgccac cagcattctc caaagacttc ccctggcaaa tgccaatgaa 2341 atgaagggga gccacaggct tcccagaggc tcaggaagca gaaacactga ggcctggttg 2401 gaaagagagc tgtaggcaaa ggaacggctg caaacaaact gggtggaagg aaaatccatc 2461 catccttcag aatgcagtca tgtctgtatt tttctaaatt ctcattgggg aacatgttct 2521 acaataagga aaacatgagt caaagacccc cagccctggt gaggttgacc gcctacttcc 2581 tcccccattc agggctgccc agccagtcct gctggtaaac ccaccaccct gccttccacc 2641 tgcctgtgtt ctagtccatc tgtctcgtct gattgggatc ctgtgccatc catatcatat 2701 tcatccctga atctcagcac ctggctctgg aaagaattca gtaaatgttc attacataaa 2761 ttatatactc agttaccaaa atgggtaaca gaagaatgga aattaaaaag tgggttctgg 2821 ctgggaacgg tggctcatgc ctgtaatccc agcattttgg aaggccgagg caggcggatc 2881 acttgaggtc agcagtttga gaccagccta gccaacatgg tgaaacccca tctctactaa 2941 aaatacaaac attagctggg catggtagca catgcttata gtctgaccta tttgggaggc 3001 tgaggcagga gaatcgcttg aacccgggag gcagaggttg cagtgagcct agatcactcc 3061 actgccctcc agcctgggtg acagagtgag actctctctc aaaaaaaaaa aaaaaaaaag 3121 agtgggatct gtctcttagg ttttcagaaa ggccagctga ctccattgag agctgctgag 3181 tggaattgct accattttat ggatgtggaa agtgagattc agcatagatc aatgccttgg 3241 ctagggcagg atcatgggct ttttcctaaa gatgcacagg gtctataaga ggcctcatga 3301 aattcactcc tttcagggga ggacctccag agaaccaagg aagaagatat tttctgttgt 3361 tgttgttgta ccttgtagtc accaagcctt aaaaacacag atcacctgat gacctcatgg 3421 atggaaaatg ctagtgaatt taggtgtttt tttttttaag acattaaact tatctagctt 3481 ttgaaaattt agcattcata cttgtattca ataaacagaa tactctaaga catttttaaa 3541 ttcaatatga ttagataaat gtgagaaagg taagcaagaa ttggttagga aaaagtgcaa 3601 aggaaaaaaa cgtaagtaga aaaagaaaaa tagggcacag tagcaaggaa atatctagaa 3661 ggaggaaaga aggctcttgg gacatactgt aggttatttg gaatgcagaa ttcaaaagaa 3721 gtaacctctt gttaccatgc tgtgaaaaat tagtatttct ctttttaacc tttagactct 3781 gtttcaggta gatccctgag ctcactcttt tatcctttca acagtaattg ggcatcctac 3841 ggtgcacagg ataccatgtg gggctctggg gtagagggat gctgtgctcc agggccctcc 3901 tgaggtcagg aggggaaaag gcaagggaag cagccccagg actcagtaag atgagaggag 3961 gcaggagcag cacagaggag gaccccaacc cagctggggt gcgggtacag aggcacctcc 4021 aggagcaggc actcaagctg agtccagggt ggggtggagg gcattccacc aagaatgaat 4081 agcaagaaca aggctgcaga tgaccctgca cagattccag catcagggat tctggccccc 4141 agcgtccctt tccttggtgt atgctgctgg aagacaggag ggggcagttc tcttttggtc 4201 cttagaaatt tccctataga catcccttct cctgccccta gcagcttata acagcagaag 4261 gccattcaat tctgctcctc tggctggaaa gcaaacatca gcctggctta ccttcgctag 4321 cctgcctgac ccccagcctt ggggtggggc taggttagtg ccctggatcc ttaaacatgg 4381 cccctggtag cacataagcc tctgctgcct ccacaaccag ccatctccat catgcatggc 4441 ctggtcctga gcctcccctc aggcagcagc cccagcctct ctgcttcctg agattcagaa 4501 acagggatcc cagggcaggg ctcagggccc agcctcttgg gggcacagtc tccagcaggg 4561 aagaggtggg cgtaggtgga caaatacatt cccttcttct tgtagtgtgc ccctgtgggt 4621 gggagtgccc cccgccccac atccacccta cctatgctca tgcccactcc tctgtgccca 4681 ctactggtgg cagggcttgc ttagcaggga agcagcagag ccctgcagag gggtgggcag 4741 agcctccctt ccaggagctg ggagaagaca cctgaagctg gacagagctt tatctgggag 4801 ccggcggctg ctgaataatg aattccaact ctgccgcact cccaggctgc acattgggtg 4861 cacacacaca cacacacaca cgcacacacc gatacacaca cgctgggctg acaacttgga 4921 ggggcggggg ctgtgaggct ctgtgagtcg ctgcaggagc agcttagctc ggcttggttg 4981 ccttggtctc tgtgggcagc atcggagggg ggtcgggagg aggaggagga ggcagcggca 5041 gagaagagag aggcgtgtga gccgtgctcc accggctagc tccttcccgc tgctcctgcc 5101 tggcagtgcc aggcagccca caccagcatg gccttgctca tccacctcaa gacagtctcg 5161 gagctgcggg gcaggggcga ccggatcgcc aaagtgactt tccgaggtag ggaagccgct 5221 gtctcagagg gacgccagct ctgagagctg gaccagccca tgctctggag gtggccgggg 5281 ataggacagg gctgggagga tgggtgggaa aagttctagc aggggctggg gcgacgagcc 5341 ttttcacagg tagtcatctg cctgggactg actggccatt gtgatttctg gaaaatcagg 5401 gtcccctgtt cttccatgcc tgtgtctcct tgtgcttgcc aacatgccag ttccccgggc 5461 agggcacaga gccctctgcc tggggaggca gaagtgagga ccacatccct gagctcaggg 5521 agacccagga ccccctcctt ctctctctct ccctctcctg caggttgatt tccttgagca 5581 cagggtgggg gccgggtatg gagcctgggg cacccagggt gactgggaga aaccaggcag 5641 ccagtagctc cctgggcccc agagtgatgg gggacactgt tggcttcttt tagatctatt 5701 catgggcggg aaccccggga gcccctcgcc tctcttctgt ctggtctttt ctcatccttt 5761 tcactcctgt attcagcgac catttattat gatctactgt gtcccaagga taggggtaga 5821 aacacagagc tgagcacaac ccagccccag ccccaaggag cctgcatctg ttgggcaggc 5881 gtggaacaag caggacaggt atgtgagaca gaaggtgggg gtgcagcatg caagctacag 5941 aagcagcacc ctcacccagg ctggtgaccg gtggtcaggg aaggcttccc ggaggaagta 6001 acactcagct aatacccgaa ggaccagcgg gtgggagcta ggagaggagg taaggactga 6061 ggaggcagag gaaacagtgt gcccagagct gagagaggag ctgaaactct ggaactgaaa 6121 gaggttccat gtgtctacag ctcagagagg gtgcaggagc ggaggccaga gagccaagca 6181 gggcaaggag gcgaggctgg acctgacccc ggggacagcg gagcccctga gcattttaag 6241 tggggaaagg cagggccagg ctgactctgt ccttcaccac ccacctctgc ctctccatgt 6301 ggttgctgcc cagccctgag ggttgggggt acttctcact agacatggcc ccttctcccg 6361 agagaggggt ctgagagtgg gatggggacg aggtggtgag aagggggcag agaggacccc 6421 cctatactaa agagcaaagt gagccttggg gcccaggctg gacacagtgt ctgcacctct 6481 gttggaaggg atgggagaga ccattggcag aacattccag caagagccct ggggcaccca 6541 catcacctac ccagaggccc tgggatgccc acattgcagc ttgtgttcat agggacaggc 6601 aggggtggag gtgatggcag tggccctgcc ggcaggcgga ggttaggcag gagggagagg 6661 gaggtgtggg ctgggctgcc ttttgcctcc caccccaacc cactgactgc tttctctgca 6721 gcaccctgga tctccctctg tgtgccacct gcaggctcat gctggcttta gaaaaagcaa 6781 atgtgtcctt tcatctgtga aatgtggccc tgagctccac gggcagcata gtgtggggcg 6841 gttaagctac aggttgccat cctgctgcag ctgtgctgga acggtccagg ctgcaccgga 6901 caggcccact tgcaggccga gaaaccaagg ttcaggggta gaacactgcg cgtggcattc 6961 acggaggagc tgaggcacgg tggtcccagc tctcaggacc tcatcctgag tactcaatct 7021 tgcaagctct ttatctgctc ctgggccacc tgggggccag caccttgtct gacacccatc 7081 ttctccttgg agcagtgaag ggctgggcct ttagcctcac tgaccacaca ggaattagtt 7141 tatttgcaac ccttgctctc tggactgagt ggagaaatcg cttccaagct ccacattggc 7201 aggaggtggc catgggcaga gctcctgggg aagggggctg ggcagcagga ataggcagat 7261 gacaagcagt ttccagaaag tacctttatt acaacgaaag atgcctcagc cgctcacctg 7321 tgtcatctag cagttcacag ttgtaggcgc cccaaaagac caacactgac cacaattcag 7381 agggaatgga cccgctctac aatgttcctt agcatctccc agcacatgca accactgggg 7441 gccaagcaag tcctctgcag ggggaaacaa gaaactggta aacacgcaga gggagacact 7501 ggccccaggc tccccaaggc ttttgagtga aagtcaatgc cgggggaggt ggtgagggag 7561 cccttggtga gctgtgccca ttggcagtgg ccctaggtag gccagagcag ctggttgaaa 7621 tatggcttga ccttctgtgc tgtgccatcc aagacactaa ggaaagagcc ctcctgggct 7681 attgtggaaa aagttctgga tatggagtca gaagccctag atcctacctg ggttctgcca 7741 ctcaccctca gtttcctcat ctgtaaaatg ggcatgataa taacactcac ttcactagat 7801 tgcttcaggg aaaccatagg tatggaagag tttgtgggaa gagtattcaa atggtcgatg 7861 tgtttgtgag gcagccattc ccattctcct tgggagcagc tgctggcccc tgaggtatct 7921 tctctccaga ccagcagagg gccccatgtg agatataaag ggaagaggag agcacgtcta 7981 aggggttcca gtctgccagg agaaggcaga gagcctggac tctgctctgt aggagcctct 8041 gctgagatgt tccgcaggaa cccaggcagg cagacccccg agactcctgt tctcatctgg 8101 ctgggtgtgc accagctttg cccgtggcca cctcttttcc cactgccctc aggccagtcg 8161 gcccctcggt cagtgctccc agccagttct gtatctagct cttagttctt actgcccctg 8221 gctgctccta agctggtgct gccctgttca tgcatttcct gaacatgcta atatttgtgc 8281 acaggcctgg gaccctgagg tgaaggggcc agcctggccc tccaggagtc acaatcccat 8341 tgggtcagac aggagatagg gagtcctggg cgaatctcta ttgtgcctgc aggccacagg 8401 gctcagctgg gtttctcatt aacaaaatgg agacagtggt cctcatttag ctcagaggcc 8461 tgcagttccc aggagtaatc aagagtgggc tatctaagaa ggagccatct tgaccacagg 8521 ttgctactca aagagaggaa gtattagctt caggtatttc ctttatcaac tcctgagata 8581 gttccctaca tcaatcacag agccacagaa cgcagggtgt gaagggtccc gaagttcttc 8641 tagtccaacc ttctgtccag tgctgagcac caaggctggg ggacctggac tgtaagggaa 8701 ccaagtgaca gacagtccag ggccaaccct gatgtctccc ttctctttct atcccctgag 8761 ccttcttgcc aagacatgag gtttggggat tttctgtgtg agataagaac atctaaaggc 8821 tggatctggc ttccacataa ttcactgtgg ctggaaattg gcacaaaggt ttgcagggca 8881 tccccctcca ccttttcatt cttactcttc ttcccaccct ccccctgatt cccaccctgc 8941 tatgttccca ctacattcaa cttccagcca ttcccaaaag ataccacacc cttttacacc 9001 tccaaacttt gagacatcga tcatatttct tctgcctgga atgaccaccc tccaccttga 9061 gaacgcccat taattctgct catccttcaa ggcccagctc atatgctacc tcctccatga 9121 aggagtagta ctttgcacac aaagtactcc tctagcagta ctttgcacac attcttccta 9181 ctgctctgcc aaggtacatt gcatttcaga aactggccac acctctgcat gctgcccaag 9241 cttttgagca tcttcaggac agacatcaga catggtttct gtctttgagg gattcactgt 9301 gtcatgggtt tgagttcttc cactgtggca ctgtcactct ttggctccat ttccccaact 9361 gtgagctctc accccagaac tttctatcca aggaggatca agggactgga agaggcctca 9421 agggccaaga accaagaacc ttggctctta ctccttccat caacttccct aacccagaga 9481 atcttctagg gctccagagg ggcctaacga tttttttttt tttttttttt tttgagtctc 9541 gctctgtcgc caggctggag tgcagtgcag tgcgatctcg gctcactgca acctccagct 9601 cctgggttca agcgattctt ctgcctcagc ctctggagta gctgggacta caggcacacg 9661 ccaccatgcc cgactaattt ttgtattttt agtagagacg gtgtttcacc atatttccca 9721 ggctggtctc aaactcctga cctcatgatc cgcctgcctc ggcctcccaa agtgctggga 9781 ttacaggtgt gagccactgc gcccagtcaa gcctaacaaa tattagcaag ttcagctcca 9841 gcccataggt gggaagcaag agggattgcg tgtgtaagcc agagtcagtt aggggaagac 9901 agaggaagga gaaagggcag acgggaaagg aggtgggagc aggctctgag ttggcccccg 9961 gagctcagaa gggaggcggg agtttttatt gagcagggga aatgggcggt atttaagaag 10021 ccaccgaagg gtcttagttc attggcagga tcaaaggcca tgaaagggcc aggcgtggtg 10081 gctcatgcct ctttccgagc cttactgcga ccacacgtgg ggcaggatct caccatctga 10141 cagaggagaa gaaacataca cacagaggtg aaatgagtgc agcatacagg agggccagcg 10201 gtgggggtaa atagcaacaa tgttcagagg atgacagctt acttagagct acagagacga 10261 gggaaaagga gcaggaggag gaagtgccta agctgggtct tgaaaaactg cccctgtttg 10321 tacctatgga gatgcaggaa gtgaggaatt ggtgatggag gaaggtgaag tctttttggg 10381 tgagggaccg accagaccag aggccagagg aggagaattg cagccaagtt ccatgtcggg 10441 gaagccacac catgtagctg gagcagaggc tataggaagt agaagaggga gaccagctag 10501 ggagggagca gtgggcctgc tgagtgattg tgcagggaag ggttgcagct gaggcactgg 10561 ggacaagatg tccccctact gttggctgca ggctccacct ctgactccac attacattta 10621 ttttccccag taaaatgagg gagccctccc tcttgatgat aaatatagct actatttgga 10681 aacttatctg ccgcccctgg taaaggaggc agaataccca gtgcacccac ccctgaaatg 10741 ctcctgcaat gcctaggcct gtctgtgggc tgtggtccag cctagcaccc cctctcttgg 10801 agaatgtgag gttggcattg tccctgctga aggcagcaat agaggggacc cttacgacga 10861 ccttggcagc cggtggctgg ctgtggacac agccctgcgc ttttgtttta gtcctaacgg 10921 atatgccccc tgcatcctcc attcttcaca gcacactcag tccccctcac cacacctgag 10981 ggaaatcttc tctgcctaat gccccacgta gtgaatgttc tcccctcctc cctcccccag 11041 agcaagccat tgcacaccag cgaagggcag acagagcaca cagaaaattc cccagacttc 11101 tgctttgata ggaagtgtat tttcatgtaa tggaaatgat tgtaaaactg ccttcccctg 11161 caaaagccct caggaatatg ctgctggaaa tgtgcttgag aacagacttg caaatcattt 11221 ctctgaattg ggaagtcttg gttatcttag ccacttttac cgatcatgtg aaagccacat 11281 ctctcgcacc cactcccatc cctgggtctc atttttttct tttttctgtc gcccacgctg 11341 gagtgcagtg gcacaatcat agttcactgc aacctcaacc tcctgggttc aagcgatgct 11401 cccacctcag cctcccgagt agctaggact acaggcacgc accaccatgc tcagctaatt 11461 tttgtatttt tagtagagat ggggtttcac catattgccc aggctggtct tgaactcccg 11521 ggctcatgtg agctgcctgg ctcagcctcc caaagtgctg ggattatagg cgtaagccac 11581 tgtgcctggc cttttttttt tttttttaac tttttatata taaaaaaact ctcaaataca 11641 tacaagagtg gggagaacag tatcatggcc ctatgttgta ccatccaatt tcagctacca 11701 tcaattcatg gccaatcttg cttcatttgc atcccatcct acttcctcac cccaaattat 11761 tttgaagaag atcccaaacc ccataccatt ccatctgtaa atattcagta cacagttata 11821 aaagataaga gctcaaataa ataccacata ctttgtcatt ttaaagaaat taataacaat 11881 tccttagtac tataaactaa tcaggcagtc atcaaattcc taattgtctc atcaatgtca 11941 taattttttt ccaatttatt aaaagcttca ttttaatgtg ttttgtaaat caggtattta 12001 atcatttatc cactcgttct gttgaagggc agccatgtgc cacgcactgg gggatggtgg 12061 ggaatgagac agatgtggtt cctgtcctca aagggggaag atgaccactg cacccatcat 12121 catgaggagc tttatggaag ggaggcacag gtgcccaggc agctcatggt gaggaaaccc 12181 acttagccca ggatgggggg aagccacccc agtgcgtgag ccagagtcag ttaggggaag 12241 actgaggaag gaggaagggc agatgggaag ggagggagga gcaggctcct agttggcccc 12301 tagagcccgg aagtgagtca ggagttttta ttgagcagga ggaatgggcg gtatttaaga 12361 agcccttgaa gggtcgcagc tcattggcag gaacaaaggc catgaaaggg ctgggcatgg 12421 tggctcacgc ctgtaatccc agcactttgg gaggccaagg cgggggggat catttgaggg 12481 caggagtttg agaccagcct ggccaacatg gtgaaaccac atctctacta aaaacacaaa 12541 aattagccgg gcgtggtggt gcacgcctat aatcccagct actcgggagg ctgaggcagg 12601 agaatcgctt gaacccagga ggcagaggct gcagtgagcc gagattgtgc cactgcactc 12661 cagcctgggc gacagagcga gactctgtct caaggggggg aaaaaagcca tgaaaggctc 12721 catcccaggc agaggggcta acactagtgc agacgtggtg gtgtggagat gcatcagggg 12781 agtgtggagg ggagaccgga aggcagggca cgggggacgc agccaaacac ggagggtctt 12841 tggtgtcaca ctcttagcag gagaatggga tgctaagatc ttgttttgga gagaaggctc 12901 tagaggtgag gactgcgggc agggacactg gggaggaagc ccggggcagg cggagggctg 12961 agtgcctcag caggcgccat gagagaggaa ggagcggcgc tgggatcagg ggagtgagtg 13021 acagggcagg gcaagagtca attgtggtcc tggggaccac cgcggaccca gggatttggg 13081 gtacagggcc ttagttgatt ctcatctaga caggtgccag ttgctgacac cctgaattct 13141 ggcaaacatg gagacatcag ggtggaaaca cctggagcca ctgccatcca ggtgggcgcc 13201 ttgagggcca ggccccttgg ctgctttccc agcagcagca tggagcctgg cacagaacag 13261 acctggcata gaagtgggag caaggaacac cgcctgtggg tgcaggagca gtgatcagtt 13321 agcaacaggg gcccccctgc agccagccat ccaggcagca ccagacagtg atccatttct 13381 ctcggtgaca gttctagaaa aggctccgga gacagggact atcatgtgat catttttacc 13441 ctagaccgct tgaccgcttt ctgtctgaac tgatccacct gctagacgct gcctcaacag 13501 tcctcgtttc tattttattt tcttttactt caaagcagaa gggctaatct gctgaggtgg 13561 agacgagttt tcacccactg gctttttttt ttttcagccg aagtttaagg taaagtcagg 13621 actgcagttt ccacaatatt tttaccctat cggagagtaa aagagtcacc ctcccattat 13681 acctcattgt attcccagtg cctggcacag aatgggtact ctacacactt gtggatcact 13741 gggaccacaa gctcctctgt caccgtaaca ggggaatcta ggacccagca gttgatgact 13801 gtgtgggtgg cactgtccaa ggctcaaaga caaataccac aggcccttcc tgcctcagtg 13861 ccagggtctg aaaaatggga accagcgctt tcagtcggtt gcagggcaaa gtcagagttt 13921 gagtgaggac ctggaagaag ggtttgagct gagccagaga gatgggattt atcatccctg 13981 ccctgcccct gcctctcaga tgaatccctg acccaagcct aagtttccat agtgtaaacc 14041 tggatgttag cagggtgggt taaggggaaa tacatgagtg gaggtagaaa tgatatttta 14101 gtacaatttg tggataataa agggttagag ttccatgggg cctccattta gctgagaaat 14161 ggggaaaatg gaaggggtaa ccttttccag tgggaggccc agggactctg cagtatccca 14221 agtctggctc tgtgagtcat tggtgatttt cagagagtat actatgtaag aaacatgagg 14281 aacagctgct ttcttggaca actctttgaa gtgaatttct ttcttctacc atgccatcaa 14341 ctgtcattat aaaattgaag atgtgtttct catggggaaa aaaattgtta ttacaagaga 14401 tatgggcaat tagacaagtc tcaatacatt tcaaaagact gaaatcttac agagtatgtt 14461 ctctgaccat agtggaattc agctaaaaat caataataag aagattatct ttgaaagttc 14521 caaatatttg gaaattaatg cctttcttaa cctatggtca aagaaggaag taaaagagaa 14581 attatgaaac atttttaact gaattataat gaaaatacaa catattaaca tttatcattt 14641 taagtactta cagcagaaaa gaagaaaagt gtaaaattgt aatctaggtt tctgccttaa 14701 aaagatacca aaagaaaagc aaattaaacc caaatcttga aaacattatg ttaaataaaa 14761 gaagccagac acaaaagacc acatactgta taacctcatt tacagtcagg catcgcttag 14821 tgataggagt acattctgaa aaatgcatca ttaagcgatt gtgtcattgt gtgaacatca 14881 tagagtgtac ttacacaaag ctagatggta tagccaacta cacacctagg ctacatggta 14941 tgacctactg ctcctaggcc acaaacgtgt acagaacgta actgtattca atgctgtagg 15001 caatcatagt acaatggtaa gtatttgtgt atctaaacat agaaaagata cagtaaatac 15061 aatattataa tcttatggga ccactgttgt atatccaagt ggtcgttgac caaaacggtg 15121 ttatgtggtg catgaatgta tacgaaatgc tcagaacagg caaatccata cagagaggag 15181 atttgtggtt gtcaagggct gtggggaggg agaatgggga gtgactgctc acgggtatgg 15241 agtctccttc cagggtgatg aaaatattct ggaattaggt agtggtgatg ggtgtacaac 15301 cttgggaata tactaaaaac gactgaactg tgcactttag aaggatgaat gttatggaat 15361 gtgaattata tttcaataaa taaaaatcaa acacccccca ccaaattaaa cccaaggaca 15421 gtataaaagg aaggaaatag aaaatagaca acagagaaat ttaacaaagc caaaagttgg 15481 ttcttcaaaa aaaattaata aaatagataa accctagcaa gacttatcaa aaataaaaag 15541 caagaaaaca caaattacca atatcaggaa taaaagaggg aatatcatta catttaaagg 15601 aaaatatggg aatattacca ataacttacc tcaataaatt ctacaactca gatgaaatga 15661 ataaatcttt tgaaaaacaa cttaccaaaa ctgacagaaa aagaaatgga aaatccaaag 15721 agcctccata tctattaaag aaattgaatt tgtaataaca atgatgatga tgacaataaa 15781 cttccttcca caaagaaaac ttcagatcta gatgatttca ctgctgtatt gtagaaaaca 15841 ttcttttttt ctttttttga gatggagtct cgcactgtca cccaggctgg agtgcagtgg 15901 cgcgatctca gctcactgca acctctgtct ccccagttca agtgattctc ctgcctcagc 15961 ctcccgagta gagcagctga gactacacgc aggtgccacc acgcccggct aatttttgta 16021 tttttagtag agacagggtt tcaccatgtt ggccaggctg gtcttgaact cctgacctca 16081 agtgatctgc ccatatcggc ctctcaaagt gctgggatta caggtgtaag ccaccacacc 16141 cggcctgtag aaaacattga aaggaaaacg taataacaat cttacacaaa ctctttcaga 16201 aaatagagaa ggaagagcac atctcaattc attttttatt atcaaaacct gacaaagacc 16261 ttacacaaaa agaaaattac agcccaatat ctctcatgaa cacagatgta aaaatcctta 16321 acaaaatatt agccaactga atagcaatat atgaaaagaa taacacatca tgacaagtga 16381 gtattatccc aggaatgcaa tgttaattta aaagtagaaa atcaaaatat tttaccatat 16441 taacacagta aaggaaaaaa ttcatgatta tatcaataga tgcagaaaat gcatttgaca 16501 aaattcaaca cccattcatg ataataacta tcagcaaact accaataaaa ggagcttcct 16561 caatctgata aaaatcatcc agctaacatt atacttaatt cagaaatatt gaacattaag 16621 atcatgagtc aggcaaagtt ttctactctc accacttctg ttcaacactg tgctagaatt 16681 ctagccagta caaggtggca aggtaaaaac aactcctaca gattggaaag gaagaagtaa 16741 aactatcttt attcacagaa aacctgattg gttatgtaga aaatcctaag gaatctatta 16801 aaaagctact acaattaatg aatgaattta gcaagttttc aggatatatg attaatacac 16861 aagaaaataa attttaccaa agacaggaaa gacttccacc ctaaaaacaa aacaacacaa 16921 aatgctgaga gaaataaaaa aaaaaaaaaa ccaaacatgt agaaaataga ttatgtttat 16981 ggactgaaga ttcataattg ttaagatgac aattctccac aaaatgatct atagactgaa 17041 tgcaatccta ataaaaatca caacaaacta ttttgtagaa attgaaaact actttaaaat 17101 ttatgtggac atgcaaatga tctagaatag ctaaagcagc cttgaaaatg gagaagagaa 17161 ttggagggtt cacaccacag ctgacccctg aacaacatgg gtccacttat atgtggattt 17221 tttttttttt tctttttgag acagagtttc actcttgttg cccaggctgg agtgcaatgg 17281 agcaatctca gctcactgca acctccacct cccgggttca agcgattctc ctttctcagc 17341 ctcccgagta gctgggatta caggcatgca ccatcactcc cagctaattt ttgtattttc 17401 agtagagacg aggtttcacc atgttggtca ggctggtctc gaactcctga cctcaagtga 17461 tccaccagcc tcggcctcct aaagtgctgg gattacaggc atgagccact tcgcctggcc 17521 atggtttctc ttccttatct tttttcctaa cattttcttt tctctagctt actttattgt 17581 aaaagtacag tacataatac atatacaaaa tatgtgttaa ttggctgttt atgttatcat 17641 taaggcttct ggttaacagt agtctattag tagctaagtt tttggggagt caaaatttat 17701 atgcagcttt tcaactatat gaggggctgg tacctctaat ccctgtgttg ttcaagggtc 17761 aactatattt aattataagt ctaactataa agttaaagga attaagaaag tgtggcattg 17821 gtctaagaat agacatatag accaatggag cagaatagtg tccagaaata aactctgtac 17881 atataaaatc aattgatttt caatcaaggt gttggatatc tagaactagg tatctatatg 17941 gagaaaaaat gaacttcaaa ctcctacctc ataccatcca caaaaattaa tgtaagatgg 18001 attatagaat taaacattaa aaacttataa gcttctagaa gaaaatatag aacatctttt 18061 tttgtattct tgggttaggc aaaggtttct taaagaaaaa ttttaaaaga ctaaacataa 18121 gaaataaatt tcactaaaaa cttgcatttc ttaaaaattg gaaactctct ttggctagtc 18181 acagagtaaa aaaaattgaa aactcctatt cataaaaaaa tcacatttaa gaaggcaaga 18241 gaaggcaagt cacacacagg aagaaaatat tcacatttat ctgacaaagg acttgtagcc 18301 agaatatata aagaatccct ataagtcaat aataataaga caaattatga aattttttat 18361 gtaggcaaaa gacttgaaga gacactccat agaataagat agacgtatgg ccaataaaca 18421 tgtgaaaatg tgatcaacat cctgagtcat tagagaaatg aagatcaaaa ttacaaagag 18481 atattatttc acatgctcta aaatagctaa aatgtaaaag tctgacagta atcaaatgtt 18541 gatgaggatg gaacaactga aatttttttt acattgctga taagagtgtg aaatgatgca 18601 atccccttag aaaactattt ggcgatttct ttcttttctt ttcttttttt ttttttttgg 18661 gatggcatct cgttctgtca cccaggctgg agtgcagtgg tgtgatcttg gttcaatgca 18721 acctttgcct cccgggttca agcgattctc ctgcttcagc ctcccgagta gctgggacta 18781 caggttcgca ccaccacgcc tggctaattt tttttttgta tttttagtag agacagggtt 18841 tcaccgtgtt agccatgatg gtctccatct cctgacctca tgatctgcct gcctcagcct 18901 cccaaagtgc tgggattaca ggcatgagcc attgcgcccg gccagcaatt tcttataaag 18961 ctaagggtac ctatcctgtg acataaccat tctgttctta ggaatttcct caagagaaat 19021 aaaattatat tttcagaaaa agactcacat gaatgtttac agcaactttg ctcatatagc 19081 ccaaccctag aagcacccaa aagtttatca tcaacagaga aatggaccaa gaagttgtgg 19141 tataggcatg caacgggcta ttactctaca ataaaaatca atacattact tatatatgca 19201 acaacatgga tgaatcacaa aaacattacc ttgaccaaaa gaagccagac acacaaaaag 19261 tacattctgt aggatacctt ttatatgaag tttaaaacag gcaaactgat ctttggtgct 19321 agaaatcaga gcactggtta ctaagggact agaaatcgac tggaaaggga catgagagaa 19381 catgtggaac aaatggaaat gttctatgtc ttgattgtgt ggcggtatac agggaaatgc 19441 atttattgaa actcattgaa ttttacactt aagatccatg aatgtaagtt tcacctagtt 19501 ttaaaaaaag aagagagact cacatctaaa atacctaaaa cttgaaaaat attatataag 19561 atgaggaaaa aaattatttc tgattccatg ctactaaaaa taagctacaa atgtgattca 19621 taatagaaga agccattttt atatttagca cataacttaa aggtctaaag gacaagcaag 19681 ctgggcgcag tggcccacgc ctataatcct agcattttgg gaggccaagg caggaggatc 19741 acttaaagtc aggaatttga gaacagcttg gccacatgct ggtgaaaccc tgtctctcta 19801 aaaatacaaa aaaagttagc caggcatggt ggcacacgcc tgtaattcca gctacttagg 19861 aggctaatgc aggagagtca cttgaaccca ggaggtggag gttgcagtga gcggagatta 19921 cgccactgca ctccagcctg ggtgacagat caagactccg tctcaaaaaa ataaattcaa 19981 aacaaaatag aatgaaggag aaacaagact atttagtaga ctgagaatag ctgtttctta 20041 ttgagggata aactgcacca aatgctattg taagcattat tatttccttc attttaaggg 20101 tgaggaaaca agggcaaaga gaagttaatt agcttcatcc agggcacgca aactaggaag 20161 aggcagctgg gatttgaact cagggactct ggcccaagag ccttaacctc tatcccatgc 20221 cccctcgtgc ttgtaaagga cttgatgctt tacttagact ttcccacaac agtttcttgt 20281 catcctcgtg atggtcccag gacacaggct ggtccaggat aatgaccccc ggctaacaga 20341 tggtgagtct gagaccccaa ggggttggat ggccagctcc caggcctcca gaccatgggc 20401 cgttgtgccg ggccgcacac ctgagtgggc ctggcttttt cctgcacgca ggggtgcttg 20461 ggccctgctt cctggtgctc catgggagta tctggccttc aaaaggaaca gatcgatctg 20521 aagtggggag agagaaaata cagcaggacc atcactcaga gagtcgctgt agaggaagag 20581 agggagagga gacgccagga catgggagct ttgtgggagg gaatgggact atttgctgag 20641 ctttgtacag cccagcccag gcagtgcata caacaaggct ttgctgattt taaataacac 20701 aaggaaatag cagccccagg tctgagtcac cagcagagtt ttactctatt tctcagctca 20761 cacagggaca atagcaatgg caggcactgc tgggagatag gctagtgggc tgggccctgg 20821 caaaatcacg acgtccttga aaacagtccc aggaccttct ccttcccctt cggatggccc 20881 accacctcac cctctgccct ttcgggaccc cagcccctct ccagtcttgc ttccacaggc 20941 tgctccctga gggcagacca ttcttgcttt tcccttcacc atcgggactc ccctgtcctg 21001 tgtccagctc cttggaggct ctactctctg ctctacgctt tcaaacattt ccttacactg 21061 ttctctctgc ctggatttcc ctccttctcc ttgcttccca gtctctctga atatccagat 21121 ttcttctggt cttctagcgt caatgcgtgt gcctctgcaa tgcctcctta atccactaca 21181 ttgagagtca ttgctccttt tcctgtgttc tcactttatt tacacttttt gcatgccaat 21241 gacaaaattc tgccttgtat catcggcaga attttccatg tctgatatat ctccctctgg 21301 attgtaatac gctcttaaag gcatcgttca gattcgaatg atcttagtac aactcccctc 21361 tgtgaaggcc aaatggcaca caagccagga gctagaaagc cctggttgcc tgtggaaatg 21421 aatgaacaca catgggctgg cagccgtgtc cctgcacacc tgccttttct cagaggtgtg 21481 gccctagcag ggtaagctgt ctggaagagg gagctatttt gtgcagatgg aacattttgt 21541 ccccttaaat catgtcccat gaaaggccag catggcatcc tgcttctgaa acaagcactg 21601 agctcgtctc catttggaga agatctgtcg tgtgggtatt tttaaatggt gaaaggagaa 21661 atgggtatat ctgataccat ggcacttgtt acactttaag cacagactct gttattcata 21721 ctccatctat tgactcaggg aggagtttat ttcaaaccaa acagctcagc tatcccagga 21781 gcagctgcct cagaaggaag gaggatgctg ttctatttcc cccatcgaac ctccttctca 21841 ctcgatccac aacagccttt ccatgcaagg aagaggctat tttctttcaa gctttattct 21901 ccattttccc tgtggcaaga aaggtgattg gatattggga tttgtaatgg ttttatctga 21961 aagccattta aaatgaagct ggaatgtcaa caagactgac gctgaatgga gtagatgtga 22021 agtggaaatg aacttgaaac aagagatggg gttagtcatc cccctgatca cttggaacag 22081 atgatggagg tcccctgcct ctgctccagt gaacagaaca gaaccacttg aatactgcca 22141 gccactgttt gtacataccc tcctgaaacg gctcttccaa aatgctgaag gacattttgt 22201 tttcttaata atttggcctt tccactgttt ctgtatgatt gatgtgtttc agcaaacctt 22261 ttttaaaaaa gaatatctac aggtaaattt agctcatcat gtttgagaat attcaccatc 22321 tctaaatccc cagggcctaa atcaatgagg ttttagcaca ttttgaaaca gaaccctgat 22381 gtataaattc tgcaatggct gatttcacgt attttacttc ctctctaaca aagctatgga 22441 aaaatgcaca agcaggggag ggtttgatcc tcggtgtttc ctgcagatgt gaatctgaca 22501 ccaccttgga gcagggcccc tccccacctt ctcccaatcc tccgctgggt tgctgcattt 22561 ttcactccaa gagaccccgg aggacagcta tatccgaggc ttattaaaat cttctaggat 22621 gcaaaggcct ttggttattc agagcagcag gtctttaggg gaagccccca tacacaaaca 22681 tgctcagctg attctcaatt tatattgtgt gttacctgcg gggaaaatta aaagctcaaa 22741 cctcaggcac tttccctctc ctcccttgat tgcccggggg cttgttgttg agatatttct 22801 tgttgatttt tttgtttttt atgtctctgg ctggtgctaa acattctttc tttcccatca 22861 tgtttacttc acatctcttt gccgtataga tagcttctgc tttatggttt tttcctcctt 22921 atctcagatg cagccagccc ttccccacct gcccccgccc caaaacacac acacgaacac 22981 acaccctttc agactgcatc cacactctct gtttcagtgg atctgacatc aacgaccccg 23041 ccacccccgg ccctcgtcag aggggagctc tgcattgaac taggactagc tcctgggtca 23101 taaaagttgc taggaccctg gagagctctt actaaacaga tgaggccacc actgacagag 23161 gagagaggtc agttcccgga gggaacgagc ctgctttgct gagccccctt ccttgcccag 23221 cccccagacc catcacaggg aaggttcaga ggagctctga cccctccagt acctccttgg 23281 cctgacgccg ctctagcccg ggctcccagg ttttctgtag ggagaggagc acagtccgct 23341 ccacccatgc catgggcttc atcagtgaca acccaaactc acccccaaat aggaatggct 23401 tcaacctgga gacagccctt caatgaaatg gtttatgctg gtggagattt aaaggtattc 23461 gtctttcggc tgggcgcggt gactcacacc tataatccca gcactttggg aggccgaggt 23521 gggagatcac ttgaggccag gaattcgaga ccagcctgac caacatgcga aaccccatct 23581 ctactaaaag taaaaaaatt agctaggcac agtggcgcat gcctgtaatc ccaactactt 23641 gggaggctga ggcacgagaa tcatttgaac cccggaggca gagtttgcag tgagccaaga 23701 ttacactact gcactccagc ctgggtgaca gagcaagact ctgtctcaag acaaacaaaa 23761 agggtgtttg tctttcaatt gcaaaaatca agcatggtca ctgaaaaaaa attcaaattc 23821 acatttcatt ttgttttgtt ttgttttgtt tgtctttcag ccaggtgcag tggctcacat 23881 caaagtatgc tgctttcaat atcttctcac tctccctccc cagggataac cactttcttt 23941 tttattttat ttatttaact tttttgagat ggagtttcac tagttgccca ggctggagtg 24001 caatggcgca atctcggccc accacaacct ccgcctcctg ggttcaagcg attctcctgc 24061 ctcggcctct tgagtagctg ggattacagg catgtgccac cacacccagc tatttttgta 24121 tttttagtag agacggggtt tctccatgtt ggtcaagcag gtctcgaact cccgacctca 24181 ggtgatccgc ccgcctcggc ctcccaaatt gctgggatta caggcgtgag ccactgcgcc 24241 caggggggta accactttca gtggtttgag atgtttgtct cttcatagaa gaaatatatg 24301 catatagttt gggttttggt atttttttta attaatggag ttctaatata catgctgcct 24361 tttttccctt accatggaat tgacacagga taataaatta attctaagca acaaattttt 24421 ctttaaccca tcctgtctct aggtttctcc tcacagaaat tacaacccct tctcttgtgg 24481 ttccatccca tccctaaaac agtatttatc ctcccttctc tgtaccatta ctgtttcttg 24541 tgcgaaattg taccttggag tatgtactga atggtgttgt actggaggcc tggcgcggtg 24601 actcatgcct gtaatcccag cactttggga gaccaaggtg ggcgggtcat ttgaggtcaa 24661 gagttccaga cgagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaat 24721 tagctgggca tggtggcggc gcctgtaatc ccagttactc aggaggctga ggcaggagaa 24781 tcgcttgaac ccaggaggcg gaggttgcag tgagccgaga tcgtgccact gcaatccagc 24841 ctgggaacag agcaagactg catctcaaaa aaaaaaaaaa aatggtgttt cccttgcact 24901 ggtgccctgt tggctcctgg cctcccttct agaccatcag ctacctgtgg gtgggagcct 24961 gtgcctttgt cattggtcca tcctctatcc cgaggccccg ggacatggcc tagaacatca 25021 gagactccag cggctgtttc tcaaagtgaa ctgaactagc tggtgtttcc cacacgatgg 25081 agccccctcg acctgccctc gattctctcc tgacttattt ctccccacat cttgggccag 25141 ttccagctgg actagcaaag agggcagctt tacctctgtg ctcccaacat gccctagtgg 25201 gtggcgtatg gatgggggag cctgggacaa tgtgtgtcca tctcacacac tctctacttc 25261 ccatgccagt ggggaaagtg ggggcaggaa tagagcccgg gagggaactg ccagagactg 25321 tcttctctgc taaggctgac aggaagacgg acaaccatga cagtggtgga aggggaaggc 25381 ccttggccca cggggaatgg ctgtctggaa gctgacttgt tgttgggggc ctggtttggg 25441 caggaacccc tggggtggct gcagaaggag gctgggcttc acagacccct gtcggcaggc 25501 aggggctacg ccccctatac taggcttctg ctcagggcag cagggcccgg agccaccagc 25561 agagctgagg aggctgcaga ggaggctgag agatccatgg aggaagaaca tggtggaaaa 25621 gagtgcctga ggtccgcttc cacggccact ctgaccagcc tgggccttct gtgccttagc 25681 attcccgttc ctaacatgga actcatggcc tttgacccgc ttccctcacg aggctgctga 25741 gagggtcaga gaagaagccg catggggact ggcctcaccc tgggagaggt gagcaagcca 25801 cgaggtccca tgttgcatga aaagtcaaat gctgttagga cgactcccag gatgaggagg 25861 tctgacccca tgctcatcgt ctggacagct ctgaccctag aatttatttc ctctttcccc 25921 acagggcaat ccttctactc tcgggtcctg gagaactgtg aggatgtggc tgactttgat 25981 gaggtaggag gcccaagact cccccctccc tcagccctga gcccagaggg gaacagccac 26041 ccttcgctgc ctcttgcggg cacacactgg ccccaaatcc caggcactgg cctgctctga 26101 gcccctcacc tctcagctgc ttcctgaagg aggtggtaag gagggtgtgc aggaactccc 26161 tcccccatgt tccccccaga aacctctgca caggtgaggc ccgtgtgcaa atgacacggg 26221 gaacagcagc ctcgcccacc tcgacggccc tgctgggtct gggcctgtta ttccctgtgg 26281 agaaagagcc cacaggtgct gtagacctga atgtgagcca ccagctgagg gcccaacgag 26341 gcaggcgagt gttggggacg tcgcaaaggc cagtctgtgt cagtccccag gggttgaaga 26401 gcagggcagc cccgggcact gaggtaggag ccccagtcac cagggaaaca ttgtcaagca 26461 ccccacctga gtgagggcgc catctccaga ccttgagggg aagcataggg aacagaagac 26521 agtctggatt ttcagaaaca gctctggggg ttccatgaga aaagacgtga gctgctggtc 26581 tattgacaac gatttttctc aatcctcact ccagctgggc tgttgtcaca attttatcag 26641 caaaggagca ggcgacacca tcccacaggg gtgcccagga gcagtgagag gacttacaac 26701 gcttccctct ccctgccctt cccctcggta cctggccggg ctgggagccc tatcctcaca 26761 cacacacacc agctcgagca gcctgcggcc tcctccgcct cctcacattc tttcgtctat 26821 gtgtttgctg cttccagaat ctatattccc ctctggctgc tgtaggttct ccagggatga 26881 ctttggagtg agggccagca gtcatccgtc accatcttag cacaaactgg aagccatgta 26941 gtgaccctca aatagtgtac cccctctctc ctggggttgg ctctcccgct tggctctgtg 27001 ggggctggga agggcctcat agcagactgt gcctcttgag gttggctgct ggcgttcggc 27061 tgagcagcca ccaggctgac acttggcacc agctgtctcc ccctcctcca gaaaccaggc 27121 cacacgatgt ggctgtgtcc atcgacccag agctggagac acagggagca aaacctcgct 27181 cctcactcag gcttaggcac agccatcaac catcgcggcc cagcaccaca ccctccccaa 27241 ccacttcagg gcgcagttgc cacgacctcc ctggtacgtc cccactgcta tgcaggacag 27301 gtgaatcact catttaaagt gaatcactag agctaaggaa gtttctgtcc ttaccttctc 27361 cccctcctgg ctgtacaatg acctcagttt ctaaacctgc caccatcttt gtcaaatggg 27421 gttggtgatg ggtgtgaagg tctctgtgaa atgatgaaca aaatgaaggg ttatggtgag 27481 agtggaatca tggctgccca ctgagacagc tgtcatagat gcttcaggct tgccccatta 27541 cacacccggc ctgctccctc ccctccccat ttcctcagtc agggcactgg gctggctggg 27601 agaagatgcc agcagcctgg cccagtttcc catagtccta cctccctggg cttctgccca 27661 ctaatccacc aggcacagca tctgactccc tcctcccaag actcccaggg gatatgtcag 27721 cccaggcgtt cagccagggg gcaacctgat gccccttcca agggcactgc cacccttttc 27781 catgcccagc gccttggaca cctgagccac aggtatgcac gacattcaaa gttaatcacc 27841 atgtcgttcc tcttcccaac tccgcccagc ctgcctcagg gggagagtct gtctctgctg 27901 gccctgaaca aggggccaca ttccgagcat ctagtgcatg ccaggccggg cttgagatat 27961 cccagaggca ggaacctggg ctcaacaccc catgatgatt tgtatgggag cttagggatg 28021 gggtagccag agtcagtgtg gagagactgg ggcagggcag aagcagttat ggaagaagca 28081 catgactagg gtcagagagc agggcacgcg atggggagaa gaggctcctg cccggggaaa 28141 gtgctgcccg cccactgggg agacagggaa gtttctggtt gttgcaatga ggagcctact 28201 ggcatttagt ggggtgggga gcaaggatgc agaatgactt gcaatgctca ggccatcccg 28261 cacttcccac ctgggagccc cgtgggaaga tggtggcagc cccagcagca gcactgagct 28321 gcttcccgag ccatgcccct tccactcaat ctccgaaatc atccacagac gaaattaggc 28381 tcagatggta actacccttc cccaggtgac agagctggaa gcggccaagc cagggttctg 28441 aattcatgca tagattagac ctaagccctc tctggataca gtgatagggc ctgactccca 28501 ccacccctgc aaggcccgtg ttggagtctc tccacacccc ctgcctccat ttctccctgg 28561 gcaaagtggc ctcagccctg gccaccaatg gtcagcagtg cacatcccac aaagcaggaa 28621 ggccaccctc ccattccctg ttcaggaacg gcccggaggc ctgggtcagc ccagtcccaa 28681 aggtagcctg gagccatacc ctggctttaa cctttctccc tagacccagt ggacaagttg 28741 taaacttccc tggcttcccc ctgaaagaat ctgcctgcca gtggttccag aatatcctgg 28801 gaaagagccc tttcaaatcc ccctgaacct tcttgacttt ccagaaagcc tcttctctcc 28861 gtcttactct gcccagggcc tgccggagcc agcttagtga gacacactgg cctgggagtc 28921 atgagaccta caccacagtc cttgctgagg aacctctttg ggctttggat tccccttctg 28981 taaaagagag atatgctccc tgctctatct gccccacggg actgtcacaa ggctaaaaaa 29041 agatgaaatg agagacaaga aagcaaatgt ctctcacagc tctactaggt aaggggttcc 29101 aagcaaggga ggggcccctc ctctgctcag gcatgggtga gaggggctgc agcagctggg 29161 cttaggaacc tgagtgggga ggaggatgcc atggaagaaa gacaatgctc tctacaacaa 29221 tgggtggaaa cagagcctgg acatggtgtc tcctttccca gaggctggaa cctgagcccc 29281 tacatttaac ctacaactct ggaaaagcta gggagagaca gagaaagacc cagcctttgt 29341 gacctgggga aacaggagta gccaccttta gccagtttgg tttggctcta acacaggccc 29401 tgtgtggagc aggccccagg ggagaggcca gagtaacaat agtacttgtg ccaatgataa 29461 gaagaactgc tgctatttac tgagcactta gtgtgtggca agatgggctg agagcttgac 29521 acaagcatta gactcactag aacttgctgg attggtagca tcctaggtga taaggagcca 29581 caacaggatt taaacccgag tctatctgat tccaggacct atggtcattt gtaaagtaga 29641 caagactcag ccctgccctc aaggggctca gtctagcggg cagatggacc cactacaaac 29701 aaggagggac cctgggcctt ctgagccaag aggaagaaga ggtctccagc ctgggggatg 29761 acagggcagg ggagtttggc cttatctgcc cctttctgct tgtaccagga agtcatggct 29821 gttacctcct ggaggccaga aacgcacctg tcttgttcgt cattggcctg gcacccagca 29881 tggagttgag aaaatgttgc cgagtgaaag aatgaaaaaa acagtgacgt tcactaggac 29941 tggcacctgt caccgcaggc ctgtgcccag accgagtggg ctcagcaggg ctagtggtac 30001 atcaagccct ttgctgtggc ctggatagaa aggaagcagg caaggcacag atgagatcac 30061 ctaaagggac tttagatcac cttgatctct aaggttagag atcatctagt ttaaccctct 30121 tgtcttgcag ttgaagaaac aggtcttaga gtggggaaga gaattgccca agaagaccag 30181 ctgagatctg agatcctaca tttaacttac aactctaaag aagctgggga aagagacaga 30241 gacaaagaca gaaacagaga gagagagaca gagacacaga gacccagcct ttgtgccctg 30301 ggaaagtgaa atagccacac tcgggatact gagcccaggc ctttaagctt gcaaatccgt 30361 ctctttccat tgtactctaa agcagcagtc cccaaccttt ttggcaccag gggctggttt 30421 cgtggaagac agtttttcca cagactggga tggtggtggc tgggggttat ttgggatgaa 30481 actgttcctc ctcagaacat caggcattag attctcttaa ggagtgcaca gcctagatct 30541 cttgcatatg ttgttcacag tagggttcac actcctatga gaatctaatg ctgtcactga 30601 tctgacatta gatggagctt aggcgggaat gctcgctcac ccgcggctca cctcttgctg 30661 tgtggctctg ctcctaacag gccatggact ggtactggtc tgtggcccgg gatatgggga 30721 cccctgctct aaagctttgt agtgcatctc aatattttcc cccaaaccta tagccctgtc 30781 cctttaagga tgctaccttg ctgatttagg atggttccag gcccactcag cggccaagct 30841 ggacataatc cagatcattc tccaaggtac atcagggaaa ccttttttgc agagtcctag 30901 atcactgggg ctgataggat gcagaaccct gtgccccggc cagcaccagc caggtcaggg 30961 ctaagcctag accaggaaac tgggtcagga ctcagcactc cccgggctcc tgagatcact 31021 ccctccaaca gaggccctct ttccctccct atctgtacta cctaccacct tgcttctgtc 31081 aacagtccta tcccaggctg ctattccagg tctgtgtctg tctccagaac tatccaggac 31141 catccccagg actgagaaac aaccctgcat ccctgcgttc tgcacagcgt catgcacaga 31201 gcctggcaca cagcaagtgc tcagcaaatg ttcgccccca gcatggggct tgctggctcg 31261 tgacatcttg agtgactgtg tttggcttaa ctgctacttg agtcccccag cagtaccagg 31321 cttcaggaga ggattcagtg tagtggatta agccctgagg actgaactcc agactaagca 31381 tcctgagact tgagtttgaa tcctgcctct gccaccaacc agccttgtgc ccgcgggcaa 31441 ctctcgcctc tccactttcc cacttgtaaa aggagcacat ctttgccatg ttgctgtgag 31501 cttggttatg ggtaaatgtg ctctggaagt actaagtcct acccagatga aattcttcct 31561 tcagaagccc ttttccttca gtcttttttt tttttttttt ttttttgagg tggagtctta 31621 ctctgtcacc caggctggag tgcaatggtg ccatctgggc tcactgcaac ctctgcctcc 31681 caggttcaag cgattctcct gcctcagcct cccaagtagc tgagattaca ggcatgcacc 31741 accacacctg gctaattttt gtattttagt agagaccgtg tttcaccatg ttggccaggc 31801 tggtatcaaa ctcctaacct caaatcatct gcccactttg gcctcccaaa atgctgtgtt 31861 tgcaggtatg agccactgcc cccagccccc tttccttcaa tctaatagct cacaagttca 31921 ataccatagt caggagagga gtgtagctcc caaaccctca aaatcctcat ctcgtcttgc 31981 tgtgttctca gcatatcacc ccaaatggag gaaaggacat aaccacaaaa atgaggagac 32041 aatgaaaaat gaaattaggg aagagaagat gcagtgaaag agacacgtga aatccacagg 32101 ccgaggcaga agaggaaagt gatggcggcg aaggggaggg aggtggcatg acaaggagac 32161 aaggcagttg cagacctgca cagagttccc actgggaaga tctaaactaa acacattctg 32221 ccgtgctgtg tcacttacga ctgctgtcac ctgtgagatc ccatttgatt ctctcaatag 32281 ccctctaagg tagatattgt cacccccctc ttttcacaga tggggaagct gaggcacagc 32341 tagtgagtgg cagagccagg gctagaactc aagtctcctg actcaaactc agagtttctg 32401 caacaccacg gagactccca gtctgcgtga gatacaagcc tcggtgttgt cagaagaaca 32461 aaaaagaagc aaagggtggg catgtccttt ggagctctgt gaggtgccca gagctcacag 32521 aggctgcctc agcaaaggaa ggtgtcagca atgggagatg gggctggaaa tgctgtctgg 32581 gcacagcaag ggggcctctg ggtgctagga aggggaatcc ccacctcttt cagggagctg 32641 tagaggagcc actgaaaagt tttaacaaag gagagataaa aagagaggaa aattcaaccc 32701 caaaagtctc cttcttacag cccatgcctc tacttccagg gaggccaaat gggagtaacc 32761 cccagtccca gaccctgagt cacttccctc cagccaagag gcccgtcacc ctccgaggcc 32821 ccacactgat gccaggaccc cacctagagg tgccggcttg atcggtctcc aggctgggcc 32881 ttgggatttt taaaagcttc tggaatggat tgcagttcca gccaagatga agaacccctg 32941 agaaagacag agggagacag agacaaaggg agagatagag acagagagag aaactgatga 33001 aagaaaacag atgtggtgag gagaagaaag cagacgaatg atgcgggagg gaaggaaaag 33061 aaatgagggg aaagcctcgt gtgggtggaa aatgcgggag ggagacaggg gaggaaagaa 33121 aggaaactgt aaggtgggag caagtcagag accgaagaag ctgctgtgac tcagtgagga 33181 ccctgtcttc tccctcaccc ggaaagcctc caagaagaac attccccgct gacataggca 33241 tggactgccc agacccggct gacgaatttc tgaaagggca cctgagccac acacctacac 33301 acgcttcccc tgattattct catctgcagt caggggcccc ggaagccccc tgtctcctgt 33361 gccctccctg tcccccgact ctcactcaac aaactggccc tcgccccgca gccaggcagc 33421 ctccctcccc aggtccctta gcctcagcct cccgccaccg ttcaacaccc cacctccctt 33481 tcacagggcc atctccaaag tcatgtcctt tttctcctga tctttctctc cttccaatgc 33541 caaaatccca cccacagacc ctcaggggga ccaatcaccc ctcccctctt catccccagt 33601 aaaccaaatc tcggtggctc ctgcggcccc ccgactccca cacagcgccc tggctgatga 33661 gctgggcctt cctgggctgc tttatttccc tgcagcccca taaaagcagc ttcattaaga 33721 aaaccacaca ctctgctgag ctgccagagg catccagaag ctggagccgc agccgctgaa 33781 tgaggcctgt gggccgggct gcctccactt cctgggactc tcagcgcacc cctccgccct 33841 gtgcccacct cgcctctgaa gccctcccta ggccctgctc agaaccctcc ccaccccacc 33901 ccgcagaccc ctctcccgct cctctgcttc ttcctccctc tcatgccaag gccaggtcct 33961 cccttgccag tcctgaaggg agatgtcaca aaggccgttt tcctgagaca ggccctgccc 34021 acactgggca gtgacccgcg gtgctggccc agtgtgccca agccctccaa gtccccaggc 34081 tgggagaagg aatctcagct ttgggaatgg caaacgtgca gggtgggctc acagaagcct 34141 cctcccgagg gcctgctcag ccagcaacag agtgctccaa gtcatgcatc tgctctgagg 34201 ccgagttcct tgtttataga gcacagaagc cattacccac ctctccggcc attggaaaga 34261 ctaaatgaat gaatatgcac gtagagcatt cagacctctg cataagaaaa agttccccag 34321 aaatggcagc gattattact attattattt attactggac tattgagcag tctgaatttg 34381 gtagggtata aaaatggaac taaaaaataa aaagtcactg ccttctacca gatctgtcaa 34441 aatcctccct gacacggtct ctccacagcg tcttgagcag acctcagcgt tgtctggtcc 34501 tgtccagaag ggcttcctac tccagtctgg catcctgttc acccctggcc atcctccttc 34561 cctcatgctt gtggctcagg atgtggagtg ggacagggac ccctgctgag gccctccaca 34621 tcctcccctg gtgggcagcc catggaaaaa ctgtcctcat atcactctac cccacttggc 34681 caatggagcg caaatagatg acttgccaca gccaacagtg gcaggctggg ctccttgccc 34741 tgctgtactc tatgggtctc ctgccagtcc actgccctgc agatgccact ggggatttgc 34801 atgccatgct gcccctcttg caggtatcta atcaccatga gctgtttccc caagaagtac 34861 cacaaaaaca ctacgcctag gacagaattc ttcccacctt tcccttgccc agtcttcttt 34921 cccatcccag gaaggtgggc tgggtgatgg ttggaggtaa cagggccttt gaggaagccc 34981 taggaagatg tctggctctg cccattggca gctttttaca gaatggggca ctgggccact 35041 ttagcctctg ttttgagcca ttgttgccac ttctagggca ccaggaaaaa tcccaatcaa 35101 attcctactc atcattaaca ttgagttagg gaggaagcaa cgaagaagtg gtaagggtga 35161 atctagaaac aatgagttgg ggacaggctg tgggcctgac cccaataaca ctaatcagct 35221 caaacctgtc cccagtgtta ccactggcag agtgaggagt ggtttgaact caacacagga 35281 gtctggggca gagcctgtgc cagtcagggt gattctgatg agagagagct ggaagctcac 35341 agctccattc agcacccacc aaaaaccagg ctcacaccca cattccttgc tgtctccctg 35401 ggacccgacc accaccctgg ttgcaccacc ctctcccaac ccccctcagg agctgggagg 35461 ccatggaagc agcgctgtgt agggagtcaa aagtcctggt aggtccaggc tcttcaccta 35521 ccacatgacc ttgggcaggt cctccaacat ctctgagcac catctttgaa agaggagtgg 35581 gcaacaatgc cggctctaca aggtggttgt tggaactaaa tgagattcca ggtgtcaatg 35641 ctttgtccct ggggagcact gggcccaagt gaggggccac tctgactgtt ggagatcccc 35701 acaagagatt cccctcccac accccacggc tcctacctgt tattgccacc gaagccgcag 35761 ttgtccctct ctccccagac atttcggtgg ccggtggcca gcagcatcga cagaaatgag 35821 atgctggaga ttcaggtttt caactacagc aaagtcttca gcaacaagta agtgtgggat 35881 ggggcaggag gggctgggcc tggacgggct gggagcctgc tcttctcctt gggctaccct 35941 ctgtttgggg cttaaaaagg ggacctacac tcccaacctg ccctggattg atcttcaaag 36001 accgaagaaa tcttgggctg gtctttgatc cccattttga tccctcttct tgtcttcaga 36061 atcccccagt tctcccagct gctgtcagcc aagaacactc caccctccta tcacctctgc 36121 tgtctccaac cccatcaaag cttcctgtct taaagactta aagctttaag tctccctcaa 36181 tgccacgctg gggtacagtt acccactgga gaggcgaaag gtggaggggc tgatgatctc 36241 ctccaagaga cactctgtag ccctgagggc aggcttgaca gtttggggtg gtggtttagg 36301 agtcaggcaa gcctgatctc agacactcag gtcagtcatc tactgtgtga ccctggaaag 36361 gttacataac ctctctgatt tcaatgtgct catgtgtgaa aaggacaagt atttacctca 36421 aagggcagct gtgtgaatta aatgagatag atattcactc actcattcaa caaatgttta 36481 ctaagcgtcg attgtgtatc aggtactgaa ttaggtgatg cagagggcgg ggtgcctacc 36541 ttcatggagc ttgcactcca caagtgaagt acacctgcca tacgagcgtt atcactataa 36601 ggtgttcaat aaaagtagtt gtcatccttc tctctgggcc atgagaagaa ttcagaagga 36661 tttgaacacg ctggaacagt ggctaagtaa tatcttgggt taaaaaatca cagccaggtg 36721 tggcacacac ctgtagtcct aggtccttgg gcagataagg cgggaggatc atttgatccc 36781 agtaatttga ggctagcctg ggcaacatag tgagatccca tctctttaaa aaaaaatcgg 36841 ttgctcttat acaagctgga ggtcatggct taactgtaac atgtccaaga aggtatggag 36901 gtgttagctc actgaggact cagaatgact caacagtggg aggagactac aaacaaaaga 36961 aaagtaggcc tcatcctaaa tcatactaat agaattaaag cactcctgat ctgagcagga 37021 gagacaagga gtccactgct ctgatactag tggcagagaa ttcctgtagg caccacccta 37081 tagtttccag gaggaaaggg actttaagtg ttaccttata acaaatggat gagagcctga 37141 aagggaaaat catagaggac atattcatcc attcatccat ccattgatcc attcatccat 37201 ccatccatct atcattcctg ttattcatcc atctgcctat ccatttgtct gtccatcaat 37261 tgatttatcc acccttcctt tctttcatcc atccttccat cctttcatcc atccattcat 37321 caatccatcc ctccatccat ttatcaattc atttatccac ccatttatcc atctatccat 37381 tcatccgtcc atcctttcat tcatcctatc catccactca tccatccatc catccatcca 37441 ttcacccatc cttcctttca tccattcatt catcaaccca atccttccat ctttccatcc 37501 attcatccac cacttaccct ttcatccttt ccattcatcc ttccatccac tcatccatcc 37561 attcatccat ccttccacct tttttctttt cctttttttt tttttttttt ttgagacaga 37621 gtcttgctct gtggcccaca gtggagtgca gtggcctgat ctcggctcac tgcaacctcc 37681 gcctctctgg ttcaagcaat tatcctgtat cagcctcctg agtagctggg attagaggtg 37741 ctcaccaccg tgcccagcta atttttgtat ttttagtaga gatggggttt caccatgttg 37801 gccaggttgg tatcgaactc ctgacctcaa gtgatctacc ctcctcggcc tcccaaagtg 37861 ctgggattac aggcgtgagc caccactttt ggcccatcct tctatctttc cattcactga 37921 tccatctatc gatccatcca ttctttcatt ctttcatcca tccttccatc catcatcctt 37981 ccttccatcc attcatccat cctttcattc ttccatccat tcatccatcc atccatcttt 38041 tcacccaact ttgcagtcac tcatcataca tatagtgaac aaatgctttc tgccagtcag 38101 acactatgct agtcactgga gatactgaga tgaggtattg aggcacagtc cctgccccta 38161 ccctcccaga aggctttttg ccacaggaag aggaaagaaa ggtgtgtacc tagaggcagg 38221 atgaggaaca ggctgctgga agacagcaga caactgaaag atagccagta ttttccagcc 38281 aatgtgctgt cttaggaggt agtgagctcc ttgccactgg gagagggtga gcaaagagtg 38341 gaccacattg tagaggggat ttctgagtca ggaaaggccc caccatatgg gctccaagga 38401 gtctctgatt ctgtgggttt tattaggagc tttcaaaatc tcagctgagt atggggcaag 38461 ggcatttcag aaatgctgtc agggccacag ggaggatgtt tagtgcacaa aggccttccc 38521 tttgcctctc atggcatcac accattcagg cagctgcttt tggcacccac aagcaaggtt 38581 ggtgagacac cccccaccag gggcccccaa ggtgaagcag agccttcttc cctggggtga 38641 gataccatga gggtgtgacc tatgaggaca ggagaaacag gaacaagtgg aaggctcaca 38701 cacagaccaa gtgggtgtga aaaaggaagg agaatcggaa gtcaagcacc agggagggca 38761 cctgagagcc cctgaaggaa cccaaccata ggtgccaaag catccaggag ctttacagct 38821 cagccactac agccctagct gtgcaggagg ggaaaccaag tctcagaggg gaacctgagg 38881 tcacatgggt agacaatggt agagccaggg ctagaatgca tgtctgttaa cttctcttcc 38941 taatccaact cccagaaacc aaaatatttg agcagtgatg gtggaaactg agggcatgga 39001 agacattgtt aaatcattta taatgaaagc caccagccta accactgaaa tgctggaaac 39061 acttgagccc atcaaaagac tgctacaaac aaatcagaag tatttgggaa atcgggaaat 39121 tgactcccat gcagtgaata tgttgaaagt tacagcttct attaggtgtt tttggttttt 39181 gttttgttca gagacagaat ctcactctgt cacccaggct ggagtgcagt ggcctagtct 39241 cggctcattg caacctctgc ctcctgagtt caagtgattc tcatgtcttg gcctcccgag 39301 tagctgggac tacaggtgca tgccaccagg cctggataat ttttgtattt ttagtagaga 39361 cagggttttc cccatgttgg ccaggatggt ctcgaactcc tggcttcagg taatagacct 39421 gcctcagctt cccaaagtgc tgggattaca ggtgccagcc accaaatcca gcctgtatta 39481 gatgttctta agtgccaata agaaggaaga cagaaagggg aatagttcct atcctaactc 39541 tcctcttctt ccctccctgc ccccatccaa gagaaggcag gaaaccccac aaggggaggc 39601 ccaggcctgg tgggagaggt tctggcattt ctttggaagc ctagagaatg cccagggcac 39661 tgctggctgc agagctgaga tgggaaagaa gaggtcccct tgtggagagc acaggcccag 39721 gctgacacag gccagcttgt gggggtcaga gtgggagaga ggtgtttgga atgatgtgag 39781 actcaagtct ccccatcctg gcatttgcct gggccaggcc agaggagcaa tgaggccact 39841 gccctcaacc cccacatggc ccagttcaga ccccaggctc cttctcatgg ggcagctgag 39901 tggaaggggt ctttggggtc tgcactaggc ttagcaatga gcaaagccat ggccactgct 39961 ggggacagtg cctggcacat ggcaggctcc tgattatttt gtggaataaa agaatgaata 40021 aatgcccctg tggtgttagg aggcagaggg taggtataca aggtgggaga gcctttgaga 40081 gggaatcgga gtggcccctc ttctctgaag gactcagggc actcaagggt gacactcagc 40141 atcacatgac cgatgcattt ggggaaattg agctaaaaga ggcatggagg agctgcctgg 40201 gagagtgggt cccaggacga gaaatgagcc tgatcccatc actgccatct cagagagaga 40261 gacttgtcct agaagcagag agtagcttgg aaactggccc ctcacccagt ggttctagag 40321 gctgccagga ggcagagaca tggtatgaag gaaggaggca tcctaggcag aaaccaggag 40381 acctccaggt ctgcttggcc ccgtttggaa caaagacctg tgtccaggaa ccttgggctt 40441 ccccatgaga aagaaatgtt cggttcagaa gattttgtgc atccagctct gcctgtccgg 40501 gacctctgag ggtccatggc ctggcctcca gcctcctgcc tgctaaggat gccagggacc 40561 ctgaataatt caggagccag gacagcagga gaggcctcgc agggcccagg acacctgaca 40621 cgggctccca ggggaaagtg atgaattatt gacaggattc tggtgcccag ttgccgctct 40681 attgtgatca gtctgtgggc ccatctgggc tggaggcctt ttcctgccgg ctaattacgt 40741 ggggatctta gctctgccca gccgcccagc ccctcgtggg gccagacagc ctcctgtgag 40801 gggtgtcctc tttgccatgg tgacctggat ggccctgtaa ggcaagtagt cagaggacat 40861 ggagttagcc ccagatcctt tgcctgacag ccccagggaa actgaggccc agagaggcct 40921 cttgtccagg gtcacacagc aggttcagga cagtcaggtc ttcaccccag gcctcctgac 40981 acccgggcca gtgctccttc ccacagaaca catggcctca caactccatt tctagggaaa 41041 tgactcagct gtctaaggag catatgagcc cacccttcct caatcgtcct gggccccact 41101 ctcccaggca gctcctccat gctgacccat gcagaggagt aagaacctac tatgtgtgca 41161 gccaggatgc acaaaggcca gctgcggcgg gcagggtcgc ctctggggtc accacaaggg 41221 ccagagccag gggcttctcc tacctcttcc tgtcccagct tcttcccaaa gaatatctat 41281 agaagacggg ctgagggatg gcatcctaga agcagtgcca gggcctttgt tttgaaactg 41341 ttttcatggc aagcactgtg tttttgctta aatggtatgt tacagacctg tagaaagagt 41401 caaggtttat aaaactgctt ttctttatac tttacataag gctgagataa tatcaattgt 41461 ccatgtcaaa aaatataatt tttactttta tttgagagag gttggggggt gaactgttag 41521 gagttaaaac cccccaagcc actcttggag gtgtggcaaa ttgattcctt taatcttgca 41581 agctcctagc gtcccagtcc caccctccag gccatagaca agctctggct gtgcgaggct 41641 gtgcacagct tgaagggtgg gggactgcct ggacctgccc ctgaagccca tcctgcaaag 41701 gagactcgcc ctgtgtaggc tctccagatg gccagccctg ctcattatta gggagggagg 41761 aggggctggc atccgagtgc cggtgttggt agaggaattt cacatgagca gtctcctcac 41821 cactgtccgg tggaagtcgg agggctatag cagaaggagc caaaaccaca ctgctgccag 41881 gaggtggaat ctcccttggg tcctgctgag tgagcccaca tctgtctgac tccagagccc 41941 aggctcctca ctgtctacac cgcttccctt tagggatgga attaatctgc atgtggacag 42001 ggcttggacc agggtaggaa gagtagggga tttgcctgga ggccaatctt gctcagcaca 42061 ctgtgtgatt aaggcagtgg ctgaatggac taccagtgac agccccatca ctgtcaccac 42121 caccggagta tctagcaggg acttaaaagc acatgtcagg gaggttgttt cagggattcc 42181 tcctggaagg ggcgctggac aaggtctctc aggttcttcc caagtataag atctgagatt 42241 caggcaggtt aagcctagaa ggcaccagac gcctctgtga gcacttgcag ggggaatagc 42301 tccaccctgc cccctgggag tgtcttgtca cattgcagca cctctgcgga tcctggggag 42361 ctgccttggc tgttcttagg catctaattc tggagaaaga tgtgcctgat cgccccacgc 42421 tcaacaggtg ctcgacaggt cctaggggaa tcaaggcagc tgaatagcca tccacaaagg 42481 gtaatagtag agcagggatt ctcaaagtgt ctccccagcc agcagcttca gcatcacctg 42541 gaaacttgtc agaaatacac attctcaggc cctctcccac ccactgaatc agagccctgg 42601 ggtcggggcc agtggtgtga actgaagtcc ggtggaccca gtttggtgac ttcacattag 42661 aagcttgaag ttggccatgg cgggagtatt tatatctcag aaaccagcaa atgctacaga 42721 tgagcacctc tcctctccca ccagtgacac attttccagc atatccacag aagaggatat 42781 cccagccgtg catgttttca caagccctcc aggtgattct gctcatgctg aagtttgaga 42841 accactgatt tagaacaaaa aggggtgagg ctgcaaaaag atgagtgtat tttttcgtgc 42901 ccgtggtcta ctgttagaat gtctacatgg tacggaagct aaaagtcccc ttccctcttc 42961 attttataaa gaccaaattg agactcaggg gcagcagctc cagggctcct ggcccccagc 43021 ccagcacttc tgtctctggg gcactgcctg agctgggaga ggtgcatgca gctatggaag 43081 aaggcttcca tgggctgctc taagggccca gaagcccagt tcggctttag agtgaaggag 43141 tggcgtggtc agtttcatcc tcagggaggt ggggcacaat ggtggttggg gctctgagct 43201 ccaaagggga gcatttcata tccattcctc atggctgccc ctaccacttc ctcccctcac 43261 acagatggga agatttttaa aaaatcaatg ttcaccctcc acagacctca gggtggtaga 43321 gacatgaagc atgtctgagt cagaattcat ctgatacctc acctcaccca gatctaccat 43381 taattagctg tgtcccttcc ccttccatgg cctcactgtc ttcctctata aatctcaggc 43441 agcatcagat gatgcccaag gtcccttcca gctctcacac gccctggatg cttccctccc 43501 ctttgtgcct tcagctagaa atggtgtgtg tattctaatc cactctatgt ggaagcacca 43561 tgtaagaacg tctgtctgag ttccctgttc tctcccagag caacaaacag ccttctgact 43621 gtggggtgca atggggttga agtcaactcc atcagcattt attgggcacc cactgttgtt 43681 cattaattca gccagcagat attgagatct ctagtgtgct agaaatgtca aacagaggct 43741 agaataaaaa gcaccaccca tgcccttgag aggttcacag tttagaggca gtacatgaat 43801 cacgacaaaa cggactgctt tggagtgctg gctgtgtgct gggggctttg acaagaacac 43861 tcgcagatga tctcattcag tcctccaaca acaactctgt gaagtagggc ttatcagctc 43921 atcttatgag aaaaccgaca ctgagagagc ttaaggaagt tgcccaggaa gcaggtagct 43981 tgctagtcag tgtcagagct gggttcagat ccctgtctct ttgatgccag gactgtgctg 44041 ttaaccaaag cattgcaccg cctctcccct gctgtgcagt tccatgggct ctgccatcac 44101 acaggttcct gccatccagg aacttacagg ctgcagatgt ggaatggatg agtgagtgct 44161 gttggtgtgg gctggaaacc ttggtcatgg ttaggcgggt agaagccgga ggagctactt 44221 gtccatccag gaaactcagg tcctttccca gcctccacac tgagcatctg gaagcttctc 44281 tgcaagggct cagctaaagc tggatttcat gcacctttcc ccgcagtctg tagacatccc 44341 ctaagggtgc tcactgcccc ttggagctct cccaaggaaa tgggcctccc acaaacaacc 44401 atccacagtg ggacatgctg ccctggctgc aaccagtcct ggctcctggg ccaccttctc 44461 cagcccagcc cagagctgga gcaagcccac ctgagtcctc cccaagcagt cacagccctt 44521 gggatgtcag tcttgctcct caccctggtc tcttccatgt taccaccgtg ccccctctgc 44581 catccccagg ctcatcggga ccttccgcat ggtgctgcag aaggtggtag aggagagcca 44641 tgtggaggtg actgacacgc tgattgatga caacaatgct atcatcaagg tgggtatgcc 44701 ccacggagtt cctggacttt cccatatggg gccatctggg ggtctgttct ccctgcctca 44761 cacatggggt ggtctgggga atgcctctca tgcatggcga ggtgtcgcag gaggaggaga 44821 ctcaggtcag actctgctgg aatggctcaa tctgtggcca tggctggagg ccctgtggca 44881 tggcagggtc tgctgcccca cagtaggcac ccctgccctt cctacggtgg gaatgcacca 44941 actggtcctt ccatttggac ccagctcagg agtcactaaa gaggctcctt ttgtcatcca 45001 aaggccagac tgagccctgc tggcactcga gggcatgacc ttcactctgc acatctggct 45061 cgggtcctcc ctgggagggc agggacctca tttcctattg tttgtcacat cccagcactt 45121 ttgcgtgagc acgcgtgcac tagtgatgca cagtctagag gcacctgaca catgttctaa 45181 caaagaagga agcaacccta ccaggacagc ctggccccag gctctgctct gattcttcag 45241 tcctcttgag ctcagccgtg gccactcatg ggcagttggc atgatggtga ggaacaggga 45301 ccctgagtat gaatcttagg ctgctcacta actgtgtgac ttaggcaagc tacatatcac 45361 ctcaaagtga gcacaattac attatccacc tcccaggact attctgagga ttaaaggaca 45421 atacacagaa agtacttagc acagatatgc acaataaatc tataatattg ttagctatta 45481 tttcctgacc tcagtttacc tatgtataaa atgggactgt gccatggtcc cccagtgggg 45541 tcctgtgtaa tatatggccc tatgtagtgg ccaagagaaa cagcctcaga agccaggact 45601 gcagccacag ggagctagaa cagaaggaac cctcttctcc catgggcagg ggtggcaggg 45661 agggcttctt aaagttaccg gggtctcagc caccacagca aggggagaag gggtgcagaa 45721 taagctatgt atggacaccc atgggaaggc gggctgggag gagaacacag aaacctggat 45781 gaagagtgta gtgtgggaag tgagataaga gaattgggga gtgagcaggg atggacagac 45841 agcacagccc atgccctgga ttttcagaat cagacttaag atgtcagcag aggaaaggac 45901 tcacggatct cctagcccac ttgccaccca tctccgctac ccattgttat gaatgggaac 45961 aatgaagtcc tggatgggga atggattcgg ccacagttga cagcagggcc agcacggaga 46021 cccaggactt ccaatgccag agaccaccat tttcccataa caacatactt ggttccacca 46081 agagggtccc atttgttcca gaaaggacat ggggcttgga gttaggcagc ctgggctcag 46141 atcccagctc cagtacttcc tagctgtgtg acttaaagca agtaacttaa cctcctgata 46201 tgctaggtaa ggtaggttgc aatgttgaaa agatcaaatg agtgtacatt aaagcatctt 46261 agcatgatgc ctagcacagt gaggattcag aaaatatgtg cacctttccc ttcccttggg 46321 aaatctaagc ctgggtgctg gagcatccaa gcactgagtg agggccgcct gtctggggca 46381 caggaccaag tcacctctag accagtgagg aagggtgatc cctgtgcact gggggggaaa 46441 ctagagctgc aagaaagtaa tggctccagg acgcagagca ggaagcccaa tcatgactct 46501 ccactgctaa gcctgagccc ggttgagtgc tctacttttt gccagaggaa aaccctaggg 46561 cagctcccaa gattccctcc ctctccaggg taggaagggt gagtgtgagc ctgggccctg 46621 ggctcctctc ccggaggcca ctttcagctc attctgtcca tttccaacaa gccgatttct 46681 ggcgggccgc gcctcatgcc tgcaggcagc ccttgttctg aggagaggag gtggcctgat 46741 catggggatg ctgaacgaca ctctcggtta tgtagacagt ggactcgggg ggtgagtcca 46801 ggctcagttg tcctgggcag gccaggcccc tccaccttga gcaccaggga ggagtggaac 46861 caccagcagc gggacctgga gccaggtacc agtaagctga cccggtctgc acaagtcagc 46921 ctttcagagc ctctgttttc tcatcagcaa aatggggcag aggggatcat accatcctga 46981 cctcctccag tgaggcaagg gtgtggaagc gctgtgtaaa caccaccaag cagccacata 47041 tacggggtgg agattgctgt caccatccca gctgctcacc accgcctccc tcccttcaga 47101 ccagcctgtg cgtggaggtc cggtatcagg ccactgacgg cacagtgggc tcctgggacg 47161 atggggactt cctgggagat gagtctcttc aagaggaaga gaaggacagc caagagacgg 47221 atggactgct cccaggctcc cggcccagct cccggccccc aggagagaag agcttccgga 47281 ggtaacaggc aggacccctc tggctgccca ctgctcccaa gacacgggga agagacctgg 47341 ggcctggtcc tactgacagg cctctctagg cctagcbggg ctcagagtac agggctgagc 47401 ttctggagag acatccaagg ggtgggaaga tgtttctgta gccccccacc cagccgtcca 47461 cccccgaggt cactgggcag ggagcaggag actcagatgg agctgcaagg ccaaggcctc 47521 cccagtggcc ctgagggagg tggagctcta acacagggat ggggctagat ctcctgcctt 47581 tctcagagaa ggggagttgg ggataggagg gcccctggcc tctctggttc aagacccagc 47641 agtgtccacc aggtgccggc agcctgacct ctaccctggc ccagtgagga ggcccaagag 47701 agggcagctc ttcctgccag agtgaagcca aagatcctgg ctgggccctg gcctttcttc 47761 ctcttgagaa gggagggtac ccgggaaccc ccagaatcca gcgtcacgcc ctgcaagtgt 47821 cctgccacct atggatcaca ggaagctgga tccaggacag ctcattccac gtgcactatt 47881 tttacaaaac agaaaatgca attgtattac tattagagac caaggggaca gaatctgggc 47941 tagtctagta agatgttgtc catgggttcc taagtcacta ggaattatgt gttaaatgcc 48001 agtaagtcaa gggtgcatct gaaggaccag ggtgtgtttt gagaagggac cctccgtgcc 48061 actggaaaca tatccctgta agctccttcc acgctttcct ttccaagtaa agtttactca 48121 gtccctctgc tgaagaaacc ataggttcta aattagtgta attgaactga catactttta 48181 tgggacaaat atgttttctc ctttgcactt gaatgagttc acaccccctt aagcacccct 48241 cacacacagg tgcatgagtg cacacgtgtg cacatacaca tacacacaca cacacaagct 48301 tcagaaaccc tgggagccag atgagtaata gtaacaaggt caaagtgacc aggcctgcaa 48361 caaacatggc gggactgtct actccaggcc agccacgggc atggggcagc cccaggctag 48421 cttaaagcct gtcccctcag actcctggct ctttagcaga aaacccaggc ctgagtccta 48481 gctctgcctc ttactagtcg tgtgaccctt ggcaagtctc tgaccctctc tcctcacctg 48541 caaagaagga catagcaagg aaatccccct gccctgctgc tgggagagcc ggagggatca 48601 cagaggaaca ggtggcaatg gaggtgctga gcgctgccca tgtccaggct ggtgacagac 48661 aaacaggttt cttgtagcac aacaatgcaa agagtcagga atcgggttgg aaattgtgag 48721 aagaggagca gtgctcagac ggggagtgaa gggatgctga ctcagtgggc accacctggt 48781 cctcctcgac tgtctccatt cagaaaagag gttggcaggg ctggtccaga aaccagaagc 48841 cgggctctaa gaaagagctt ccagagaaca agatcggaag ccacacaagg gccatcagtc 48901 acagggaaag gaatgctgac cccaaatcag gagagctaag gcccattaag tcccatcttg 48961 actgtgccac tcattggctg agtgacactg ggcatgtcac cagcccctgt aggtcagtga 49021 caggaatggg ttcagcaagt tacatctggc tcccctccaa ctctgaggtc ctaagggacc 49081 catggatgct ccggacctgt gggtcacatc catgggaaac aacatcctgg gagcccttag 49141 cagccacgaa ggcaacctcc ctggggtggc gtagcaacac agagccagtt tctcactcag 49201 tcctaagaga gtgggccagg gtgctgatgg gggctctgga gagcttagag tcccagagag 49261 ccctaggcac caggaatctg gagataagag ggctcccccg acccttcctc acagcctggt 49321 ggcttcccca cctctcccca tcttcgtgtg gcccctccca gggtagcagc aagaagcggg 49381 agcaaaagga ggggcttcac cccggactgg gaattgggag agggtgacag ccgaagccag 49441 gcacccccac cctgcattgc aggggcagtg tgcaggagca cagtttccct gctgccactg 49501 gggctgccag cccaggtttg agagcacatt ggggacaggc atcgctgcta caccttctcc 49561 cgccaggcct agccatgcag ccagcaggcc tggttgtgga aaagaggggt tgagaaaaat 49621 tctagagatg ggccatttgc tggtgaggag aaggtggagc gggttcaaga acttggggtt 49681 ttcctgtagc ttaatcctgg ctgcccatat ggggccattg agttctgggt caaggagtgc 49741 tgaggtgagg agggggacct ggaagctggc cccgcagccc tagatgttgc atctcaccct 49801 tgtcacatag tgtgggttct gggaggaagc cagagagctc tccagaaggg acttggccaa 49861 ccttttatca ggaaaacacc tactccttaa agaggacaac accggggaag gggtgtcagt 49921 gcctcacctc tgaccccgtt aggagcccag gcaggcttcc cctgcatctg ctccctgccc 49981 tccatcctct cctgggaagg ccaatcccct tatagatcag ggtattcaat aaccacagtt 50041 ccctcttgtt cctgctttag ccacaatgag caagaggaaa atcccgttgc tggcaagcag 50101 cagtgtctca ccggccatct tgaccgttag ggtccggcgt ggggatcagc cgctccctgg 50161 ctgatggggt gaaatgaagg cctgctgggg gctgcgggga ggtagactga gtgggcagga 50221 aacagcctca gcccagacag gccccgggca gcccaggctg gaatcttcca cggatggagg 50281 ggaggctgat gccaggagat cctctgggca ctcctcacct ctccctccag ggcctgggtc 50341 caccccccag ccctgccctg cctggcctgc ttctctggga cttcacccac attcatcctg 50401 tcctcactct gggggtcaga tggttctaag caggggcagt gtggacctca ggcctcagct 50461 gctgtgacac tcactcctaa gaccctaaga atctgccatg aagttacccc gttcctcctc 50521 agggaatcag tatgggggct ctgcctgaat gaccaccaac cccaccgccc actgactctc 50581 tgccccaacg attccacctc ccctaggccc tggtcagccg catgccctct gagccactct 50641 gcccacttct ctagttcctg ccacgaagcc ctgatttctg ccggcttttt gcacaatgcc 50701 cccggtaatg tgccaggaag ctgtgctgtg tgacagagca caggctccac tcacagctct 50761 gctattggga acccccctcc ccatttgtga gatggggctc aaggatgcct cacagaagtg 50821 ccaggattga gtgaggtgca cctgcgagtc atccacccct gtgcctggca tgtggcaggt 50881 gctcagccag tgttcacttc cttcctcttc actgactcca tgttaccctg atgtcaactt 50941 ctaccccgag cagcacctga ccctcttgtt caggtgctgt ccaagcacct tctcagctct 51001 tgctccccac cctataccaa gggctctgca gaagctgccc acacaggagc cttactggcc 51061 caggggcagg tatagggagc tcatttactc aaagttcccc tcacctcccc aggctctcag 51121 tgttgcagag atgtaatgaa tccctaacct catgggcgct ccactctcag cagcacaaaa 51181 tcagtgttcc agacccttgc atggcagcgt atgcctgccc tagtctctgg agagaaagtg 51241 acttcggccc tgaccacact cacatgcaca cacatgtgta cacaagtgcc catgtgtttg 51301 cacacactca catgcactgc atgacaccag ggaggactct ggattctggg ctctgctgtt 51361 gatgctgtct ttaggagtca catcttagag aggacaaaga aagaaatccc agctttagtc 51421 ttgcagctaa actgtagaga cctgagcctt tcctcctgag tcccagtatt ctgcgactat 51481 ctcctcttct cattttctcc acctggcctg gctctcctgc cctccacgac ccccacctcc 51541 ttctgctgcc caaaccctct tctgctggtc tcctctctgc tgggtctcat ctgggaggag 51601 tttggggcag gagccacttt tctcattctc cttattgatc attcttccac tccagtggag 51661 gcctgcagaa gccaggtaac ttcctcctat gctggggcca gagggcagtg gggcacgtgt 51721 gcatggtggg gctctgagac agaggggcag agagtgggca tgcagaagtg tgtgcatgtg 51781 gggccagtac atgcagcctt accccaagag tgtttttaaa tcggtttcca cagcccctag 51841 agagctagaa aatcctctgc tgccttcctt ctccaggctg agccccagag ttgcagcagc 51901 tcccaaagct gctcagatga gccggggcag ccgggcgcac tgggattttg tgcttgagac 51961 acattcctcc tcctatgctg tgagctcttc tccgcttagt agtctcagct gatgtgggca 52021 gccgaggcct ggctgatgtt aacacctttg aattacagac tgacctgctt gcccaacgta 52081 aaggttagct ggccagcgct ggactgcagc tgtgctgtgt ctaggccttc aggtcttgag 52141 ccatcaggat atgcagtcaa gtctacctgg gcaaggcctg tgccagaaca gggtgtgagg 52201 agaggaataa tttgctaatt gttattcact ttcctgtctt catcctcatt gccacagcac 52261 tgggaaagca ttgagagaac attccagaaa agttttctgg aagcctccct aaagtgagat 52321 aggggggccg tttttccctg ctctgagccc tggagtggta gctcacttac cgccccacct 52381 acacccctag aactgccccc aaccacccgt gtgcactcca tagcaggacc cccagccctg 52441 cctcaccctc acagagcagg cttagcccac tgttccccta gaggccccca gagcctggga 52501 gctcccaccc cattggaggg gagcagggga gcaggggagc cggtgggcag aggagcaggg 52561 tggcccaggc cgggagggtg gccaggctca tctaaccctg tgttccctga ggaagctgcg 52621 acccacattg tggaatcatc agatcttagc ctggtagggg cgatgagctg aggccctgag 52681 gtatcagagc ttggggttgg aatagtggcc acccaggccc agcactgtgg gcccctccca 52741 tctcccccaa ggcagaaccc agggccatgg gacccctttt ctgcagacct aggcttgcta 52801 ccgtgcgaag ctgtggggtg agaggtctgt gggacaagga ggcccccggg gagcgtgcag 52861 gcccgtgggg ccggggctga ggccagtgtc tctggtccac agcccctcac acgtgtcccc 52921 ttgtctcctc atttcttccc cctactcagc aaaggcagag agaagaccaa gggaggcaga 52981 gatgacgagc acaagtaggt gtcccaggcg agggcagacg caacagcgtc tctggggaga 53041 cagaggcctc ctccccacag gctgtggagg gcgggatggg ctcggctgag agggctcagg 53101 agtgggctgt cgtggtagag ctggcacggg tcatggaggc ccagggaggc cttttcacct 53161 ggccacgggg gtgagggatg aggaggggtt agggtcgcgg gggaggtggc cagaccttct 53221 ggtttccact ctgggctctc gggggtgacc atcctcctct ccgtgtcttg ttcctcctcc 53281 actgttcagc ccccatcctg tggccttcgg gcttccctgg gagggagggg acagctaaag 53341 gctaagggga gaggggcatg aggacctcag ggatccctct cccaacaggg gcgaggtagg 53401 gccaggcagc tggaggcata aggaggagga actctgggta ccctttgcag ctgcaggtcg 53461 tgggtggagt tggagacccc cagaaagctt aggagaggcc accatttggg cggccctctc 53521 tatcttcatc tccccaaaag gcttcctgga aaaatgaggt cagggtgctg tctggagagg 53581 acaggagaag ggtcctgcag gtgggagggg ctggtcacaa gggtctggaa agattcgaag 53641 gctgggagtt gtgaatgggt cttgtaggca cccctagaag cacactgaca tctggaggac 53701 tctagcatta cgggatctca taagggcagt ggtagccaag gtggaccata ctggaggagg 53761 cctctggtta acacctgctc ttacagatga caaatctgtc tcagaacagg ggcagagctg 53821 gaaccagaag acagggaagc tgacttctga cccagagctc accatagacc caggaaattt 53881 agagaacttg actgtatcta aatttaatct aattctccaa acataccaat gagagctgaa 53941 aagccaggag tgtggtcttt tttatcttcc agataagcaa cctgagcccc agagatctta 54001 agagatttgc tcaaaactgt ggcctcaata tattaagaat tagttcatct gaagatatca 54061 tggaaatatc aggattgtgt gttgaggggt ctgaactgat caacactggt gtgggcttgg 54121 gatatccact ggcattaaga tcctggggaa ctcacagcct cattcattgc ttcaaaaaaa 54181 ggtatgagtt ctaactcgca tttgttacgc acaagcaaaa gcaatgatga tgcagtgtta 54241 actctgtagt gatggaggaa atggcgctgt gtaggaagag ctccagccca gagacctgaa 54301 ggatggagga gtttgccagg ttcccagtaa gggaagacac gtaggcagag catgtgtcaa 54361 ggctcagagc cagggaactg aatccagggt gggtggcgat gatggggaat gctgagctgg 54421 ggagtcctct tagggagtcc tcaagggttc aggtttctcc atagatgctt agatgtaaag 54481 ggcatatgaa tgagatacaa gcagcctgtc catccccagc ttctctgcct gagatcagcg 54541 atgctctaag gcccttcttg atgcccagct tcccagtctg tcccaggcca gacccacagg 54601 gacacagact ggcctgatcc ctttgactgg ctacagttgg agtaagaggt acctcacagt 54661 gccagcacat agtaggtcca ccaaaatact ggtttcctag cacttctctg tcctaatttc 54721 ttaccatctc taattagcac atgagataaa gtaaactggc atatagtatt gttattatta 54781 ttatgtgtag agcaatagga ctattgaaag aataggaaaa tgagatttct aagaagagat 54841 tgaacaaatt taaactcttt agcctggagg agagaaaact gtggagacag atttcaatct 54901 ctgaaatgtt aatgtgtggc aaagctggtt ggtatctatc tccactgaga agagataaat 54961 ggaaataaat ttaagttgaa gttaagttga agtagagaaa caagattcaa cccacgaaag 55021 aactcatagt gtgtgacatt ctgggatagg ctggtttggg gagatgagaa aacacccatc 55081 atcttccatg atgctgcttg cttgagcctt gcaaagggct gggccgccag caagaactga 55141 agagccagct tccctgacaa tcctggggtc aggacaagtg tgtgtgggtc ccccaagcct 55201 tctggtacaa cgtgggcaca tgtgcaaacg ggccagtttg gagacagggt ggttcttgta 55261 taaagggtca gcctatcctg cccacctatg gaaagctatt caaaaactaa ctgacattca 55321 acacactttc aaagacacct gtaaagacca aaattatgaa attccctgtg ccttggggca 55381 tggaaaattt ttaaaataaa cccatttagg ggcgcttgga taacatgctc cgaggttttg 55441 aaaattgggc tgtttgagca atgcaaagaa ggaccacaga ccctatttct catagacagg 55501 agtctttatc ctgattgatt acctgaggcc tgagctaatg agcctagtag ttccagttga 55561 agccagtcat ggggcagaag ccctgggcag tgaatggact cgacctgcag ctcatttatg 55621 gtcaggtctc tattagcttt cagaataatc cagagacctg aattaatgaa acactcgggt 55681 cactaaattt agtttggtga atgttcccaa gtcattatga atactaagct ctacctagga 55741 ccctgtgtgc accacacagc aacacgcttc taaatctggg ccataaaatg agcggagaaa 55801 tcatcagatt tatagtttac aataagtgaa ctaattttag catttttttc ctctagagat 55861 aaataccagt ctagattgta ggtgcatttc attctgacca tggtgaatgt agccacagga 55921 aactcaaacg gattctaaat cctcagaggg tcctgggata ctggcctccc cttggctctc 55981 acttctcaag ctttaatacg cccaagaata aggagccatt tgattgtaaa gtgagttttc 56041 actgagttga ttattggctt gttttctttg tctgtttctc accatatcct gtttttggta 56101 attgtagaac tcaactagac caaatgcaga attttacttt gaaaacaaaa aaaggccagg 56161 acaacggaca cctcaacagc aaattacatt ttttgaaatc taagtctttc agacaaatag 56221 ataatcttca aaattccctg attaagttga catttatttc aaaactctcc tttacagttt 56281 gccaagagaa gtaggcatac tgctttctgg gaactggtgc tgcaatcagg cagaaaggct 56341 ttttctatag tgaacttctg atgtgttact gatcagaaaa ttacaaaggc tagtggcagt 56401 gatgacatca tgctgtactg atcacaattc agattcattg aagagcaagt ctaggagaat 56461 cagaggtaca gagcctgtag taagaattct ggaaattaca tccttcacta cacatttctg 56521 catttttaat aaagggacaa agacaatatc cttttgagat attcccaggc acacaggagt 56581 gctaccagta ctaccacttc agacagctaa aactatgcag ggttggaagg gagagatttc 56641 tcctttcaat tgcttcaagg tgtagtagag atagttggac aagtatagtt tttgtttgtg 56701 tgtttgtttg agacagagtc tcactctgtc gcccaggctg gagtgcagtg gtgcgatcgt 56761 ggctcactgc aacctccgcc tcctagttca agcgattctc ctgcctcagc ctcccgagta 56821 actgggatta caggcatgtg ccaccacacc cagctaattt tagtagagac ggggtttcac 56881 catgttgacc aggctggtct tgaactcctg acctcaagtg atccacctgc ctcggcctcc 56941 caaagtgctg ggattacagg tgtgagtcac cgcaccggac caggacaagt atagtttttt 57001 aaagcctcaa tcatttcttt caaatctgtt tgtgttaaga aataaagtga ctttcaaatt 57061 caagggccat aagtgcccca gggatgcctc aggtcctttt ccacctgggt gagtccatgg 57121 gaccagcctc tgaaagccac tatttcttgc taccttgcac tccccccggg actcaggcag 57181 cagggccaga tcccatccca gcaggccggg cagccggctt ctccaggcag ggcctgcttc 57241 taacctacca tctcagagca cttcccctct ggggaagtgg ggaaggggca ggggagaggg 57301 aagtctgtgg ctggagcagg ctgcaatggc aaaggctaac tatgtaggtc acacatgcgg 57361 aagggccaag gactccaaga ataacacagc ctaggaatgg ccaagaagta atggtgcaaa 57421 gtcaaacgct gagccctgca ggagactcct gggtaattca ggagagacat agttgagcag 57481 cacggctggg caaaaaggaa tcccaagcac tgagacagga agtgacccac gaggaggccc 57541 acaaaaacta cacttctgaa gctgggccta tggcaggggt caggacagcc agcacccctg 57601 tccttggggc cagcaggtgg ggcaaaatcc cacaggatgc ttcagggcaa gccagccagg 57661 gtggtccttt ccccaccatc acacgattat ttctggtggg ttcattgatc tgttcaatgt 57721 tatgtcacca gcaatttaac atgcacagca gtcccttccc aaatgtttgg gtgctcaggt 57781 tctttttgaa tgagcccctt ctttgtaaac atgggtatga tctgtgagat tccacagatg 57841 acagcatcct gatctgtaaa ctatgctggc acacagacca tacctgtacc tatgggtgcc 57901 agccctgggg ccttttagct aaaatcccaa atggtcagga atggatggga ttcttgccca 57961 cagaaaagtg cagtcctacg gcatcgaggc aaaggacctg agatgcagta aaaatattgc 58021 tggcctagaa cacaggagct ttctgcttca atcccagttc tgccactcac cgtgtgacct 58081 cgcgattatt gtcccctctc tgagcctcag tctttttatt ggttgaatga ggagaagtat 58141 gtggccctca gaggattgcc aggaagatga aatgagcaga catctgcaga cattgcagac 58201 atctagaaag gcctttggcc ctatgtagtc tctttttggc ctgtatgtgt gtgtgtgtgt 58261 gtctgtgtgt gtgtgtgtgt gtgtgtaact cacctccccc atcagaaggg aggaagcttt 58321 tgaaaataat tccaaaggca tcagctttga ttttagagcc tctttctttc cctttcttct 58381 cattgtcgta tttcagatgg tatgctactg aagagtgcag acacatcagc cttcttccat 58441 tcctttttag gaattcaaag aacatgctaa tgttccctaa attgtgagct gctgccacgt 58501 gaaaagggtg attctcaatt gctccctcac tgggatatga acgtgctttg tcctgcatat 58561 gaacagtaaa gaaaggtcct ggggttggga tagggccagg tttggggaat aagattggcc 58621 ccacaatcct gaggagaggg gcttgaggtt tctaggtcat ctgcctgagg acagaaaggt 58681 tttccccaac ctcctattgc ccagcataaa gaacaaggat ctggggtctt agaaaccata 58741 gtcaagcctc cacagggaga tgtgtgaccc aaaaagggtg gactctgctg taagcgagct 58801 ccaggttgga gcctacacct ggctccacct ggacctacag gatgatgggg ccatacccag 58861 gaggagggag aacgggaagt ggagagagtc aggtatccac tcatgcaata tggatggggt 58921 aatggaacac tgcactttac cctctgctga tcctgctcct ggggcttcct ggtgccagga 58981 accacaggct cggctgcagg gacatcactg aaggacagtg aggacccctg ccccttttcc 59041 tcagccccgc tgactgcaag gcccttcacc tgggggcaca aggtcgcagc aagccagagg 59101 aagaggtagg aactatggag cctgccataa gttcctgggg ttgggggaaa ggggaatttg 59161 gcagtgagag gggacaggta gaaggggcaa aatccaggac cgaagataga tgggaaaggg 59221 cctatctccc cctttttcat ggggaccaag gagcatccca gaacacggag aggttggaga 59281 aagacaagtc aggctttgag caccagggcc atctgagaac tgaacagctc gtttcaacca 59341 catctcccat ctcctcatcg gcctctgccc ctgagtcctc tctggtccct gccccgccgt 59401 tctgatgctc tgtctccagt cctcgggctt tctctccaac cagctgagcc ggggaggatg 59461 agcgtgggga cactggcagg gctcggagct ctgaggagac tagactgagg ggctgggatc 59521 agactgaaaa gtccaagacc cagaggagct ccagttaaaa cggctctttc cggctcaaga 59581 ccacgttccc tgcttgctgg ggaccccatc cctctcctcc gtgtgtgaaa ggatggcaaa 59641 ggcggaagtg gaggggtctc tcactgccct gattccccct cctggctccc aatttgggaa 59701 gacagatccc gatctgtctc gggaccagta ggtgaggggc cgggtccatc tcccttctct 59761 gatgtgttct ctcatgtttg gctcttctgt gtttgtgtgt tttcctccat gcgtccctct 59821 ccctgcacct cattctggtg gcccccctca cagagccggg aggagcgtgt tctccgccat 59881 gaagctcggc aaaaaccggt ctcacaagga ggagccccaa agaccaggta ggacaggtgc 59941 cgcgtgagcc ccgcagcccc gcgcctcgcg gcgccctccc gccgctttcc agcccctgcc 60001 cggctgccaa aaggccctcc tgggataggt cgtcccaggg ccaggcccca cccagtgatg 60061 cgtggccctc taggaaggag acgccctagg gccgagggag ggaaacgggc agcgccctct 60121 gtcgggggtg cctggttaca aggctcctcc cgccctcgtt gctcccggtt cttccttctt 60181 cacgcagaag cccagtgttt taattagagc agagaatatc catcaagaaa cgctgtttgg 60241 ccaactccct atttctgggg ggaaaccgtt gtcccactag tacggggtcg gcggcaggcc 60301 tcgcccaagc gctctcacca ggctgcagcc tggcctttgg ggaggtcctg gggccgctgg 60361 agggcgcggc agggccgggc ctgggaggct ggagcagcag gtggcactgg gccctcccgg 60421 aggagcgact ggagagggga agacagctgc tgcagaggag gcgggaggcc tggaggaaga 60481 caaggggaga aatggagagg acaggggagc tgggaggggg ccatcttctc catcacgggc 60541 ccaccatcgg ggctcccggc tgccctcccc cagcatcccc tctgtggcct actggccctc 60601 aggctctctc ccccaccctc ttgcccccat gccaattcca gccgtgccct tcaccttctt 60661 aaatggagag agtacagctg ctggctgagg accaaaccca gcatccttgg gtggctgttc 60721 ggaatccaca tgtctgcatc tcattagatg aatacacacc aatgcattag gttctgaatt 60781 ccatcagctg tttgatatgg ataagttact tcctaagcct tcgtttctgt acctgtgaca 60841 tgagaataac gcccatcttg gcagggcaca gctctaagga ctagagatag tcatgtaaag 60901 tcctggtgtt gtgcctggaa cagagagtat ccacccaaca aatggtagct atttattgag 60961 aggtgcaaaa gtatggattc tttattccct accttcttcc ataagagata ttcagtgcct 61021 aagtaagtgg tatacaataa aagagcattc aattaaaata aaaaggcaag accagacata 61081 atggccattc aaatccaaga tcgggattag gtagaaaaac actgcagtta ttcaggccat 61141 aatattctaa gcggtagcaa ctaagtaaac ctcgaattta actctcagct ttctggatgc 61201 cagagtaaaa ggagaaatgg tcactatctc accatcagtc agcccaccta accagtcttt 61261 catcttcccc agatgaaccg gcggtgctgg agatggaaga ccttgaccat ctggccattc 61321 ggctaggaga tggactggat cccgactcgg tgtctctagc ctcagtcaca gctctcacca 61381 ctaatgtctc caacaagcgg tgagtggacg ggagccctgc aaccccagct gcccccaccc 61441 tgtcaggcag gacctggctt gccatgattg gaatttgggt agggaagaat cagggctcat 61501 ggacggcttc ttcctaacct aaccttaccc ttttctgctt ttccttgggt gtttttctca 61561 cctctctccc tgcaaaagca gagcacagca gctgcaggcc tgttctcagg tccttgaata 61621 cctcccagcc caaggaagcc acagacctgc ccaccccata tttgaaccta ttgaccccat 61681 gtctgtctct ctgttacttc tgcctttgat tagttctctg tgttgaggcc tctgaagaca 61741 actaatcctc actattcttg gcagtgcttg agtgtttaaa gaccatgatt ctgtccctct 61801 gcccactccc aggtctaacc actgccagtg tcctcctccc caacaagcag tccccatacc 61861 ccaggcctga tggtacattc tcttcctcag atctaagcca gacattaaga tggagccaag 61921 tgctgggcgg cccatggatt accaggtagg tgggcacctg gaggcctcat gtctttcaga 61981 ctctgctcta gtgggggatt ctagccggat gtgcattatc cactatactg aggcatggat 62041 ccaggggtca tagagaacaa caagctgaat ataagttccc aaagtaagct tgttcctggg 62101 aggcattcct agaagtatca tcagtagaga gatacaaacc caaagaaaag cttgagaact 62161 ctgcctatgc taatcaaagc ccttccagta tttcatgttc agtattggac ttcataaagt 62221 gagaagcacc tagaaaaacc ataaagagac caagaactac aaaaaagtat tcaaacagtt 62281 aaaataaggg cctttgaaga aagttttcct ggcatgattt ttaaattgtt gttttgtatt 62341 atttgattgc tggaagtaat gacgattctg tttatctctg gatggtgaga ctgtgagtga 62401 tttttttctt ctttttgctt ctctgtattt tctgagatta acacaacttt tttatttgtg 62461 tgcttctaag accagagaca aaagactgag acaaagagag gttgacagct gtaagaatgt 62521 gaatgtggcc aacagtgcag gcaggacagg tgatgagcat gtctggtggc tgctgggaca 62581 ccatctctca ggaagggccc agggaccctc cattgctcca gaccctccct tggaggctaa 62641 caggactcag ctataaatca gaagactgct gggctttcct aggattgagt tagaatgctg 62701 gctgctcaga ggggacaggg cttgcaagag atctcacctg gctgccactg cacttctgtc 62761 ctggggatgt tcggtctggg tatcagcacc aggccccaga atcagagtga gccccatcta 62821 ccagggtaga gctttatctc tgatgcctag ttccagaccc caagcacact aacccttctt 62881 tacggacaac cccacctccc ctcactcagg tgatgatgga aaggataaga tggcactttt 62941 ctatgtaaaa ggtacatctg gccatgtttt ctccagaata tacttcatct cccttcatct 63001 ttgttttagt tagtttccat ctactcaggc aactgtcttc ccaggtgcct gaaaaacagc 63061 cccaggcaat gtcaaacgga cctgcccctg tggttttaaa taacttcaag ccattggatt 63121 ccttaggggt ttgagaatgc cggcccctca cctctgccaa aacccaaaca caaagtgtcc 63181 tgagacttcc gagggctttt ccaagggatt gggctcaggg ctttgtttct ctgtgtgctg 63241 agaactggag aattccaaag aacaacgacc ccaactcagg tatcatgtca ctggcctaag 63301 aggtaaggac acatcaaaaa tagagtcatt attgttcatg aaacttattt ttgaaggttt 63361 attctatgcc aggcactgtg ctaggagcta tatatgtatt tccattgaag ttaatgtaat 63421 tcttcaacca cccaaatata ggtgttactg catttatagg taagaaagtg aggccccagg 63481 aaggtcagga acttgtccca ggtcgttgcc actaagttag ccaaggttag agccagggtt 63541 caaggccagg ggtgtctggc catagccata agagcaattg acttctctat atcaagcctt 63601 ctagacagct gctcccttcg ggtccctggt tcatcttcat cttgctactt agtgcttgtt 63661 ttccaaacct tttcaaactg cctcctacca gagactttta ttaactggac cagacattgt 63721 cccctccaaa gactttttaa accgaactga acaaaacggt tgttgtattt aacctggtag 63781 catagtgttt cccgacaagt tcattcacaa ttaaccttgc aaacatttga gtgagagcta 63841 tgaggatgca aatgtgaaat tattttcact tccaatacat acagtgtata atgcaataaa 63901 agcaggccgg gtgcagtgac tcatgcctgt aatcccagca ctttcagagg ccgagatgag 63961 tggattgcaa gaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa 64021 attagccagg catggtggtg gcgcatacct gtaatcccag ctacttggga ggctgaggca 64081 ggagaatcac ttgaacccag aaagtggagg ttgtagtgag tcgagaccgc accactgcac 64141 tccaacctgg gcaacagagg gagaccttgt ctcaaaagaa aattaaaaat aaataaataa 64201 ataataaaaa gcaataaaac cagatacgac ttcactctct tggagacttt gggtttgatg 64261 agatataaag accgcaggaa ggacacctcg ttggtgagat gtggggagac ttagctgaac 64321 tcagatccag gaagggttgt gagggctcag gaccattcta aaggttatgg cactgaaaga 64381 agcctggagg taaaaggacc gcggcgtacc catgctcttt gtttcttcca tttagaatgc 64441 acgtcacgtg taaactcttt cctgattatt gccatctcca aggcaagaaa ccacagtcac 64501 ccccctgtga atgtgcagtt tccccaccag agtgagcaac gcttggcact tggcagagat 64561 gttcttggtg gatcaagggg tcttgagtct ctttattacc atctcttcct ggcaccaaga 64621 cttaatacat tgtcacccaa catctctcca gttttcacct ccatttcatg cccctgccac 64681 tgacctgagg tccccagcct caactgcatg gttgtaccta ctttctacct ggtctccctg 64741 ccctcatatt gcctcctcca ctccaaactc catgccacca ctggagcaaa cttctgaaaa 64801 tgcaaatctg gtcatgtcac atctctgcca cctggaaaag tggggagtgg gtaatggatg 64861 ttgcagaagg acagtactaa agggcgcacc aactctcatc tctggctccc agcagatgtt 64921 cctgaagctg gatcaggtcc ctgggaagca ggtcacaaag cattattact ctcgggtttt 64981 cccaggacag gggtatagat ttaccactca gcattattcc ttgtgatcgc tttcatgaag 65041 ccactgggga gtatgtccct tatcttgaaa ggagatggtg gaatagtcag ctggtcagtt 65101 ggtcccagct gtggctccgt ttgcctcttc atcttccacc ctggaaaaat tgagtcctct 65161 gctgatgatt ggagagaagg atggccaagc ccctccccca gaaccctgga gaatgaccag 65221 ccatttttta ttttttattt caagtgcatc atttcccctt cctagagccc caggaggggt 65281 gggaggcagc aggaatggca ttccccttcc cccaacacca tgcgcctggt ggtctttctc 65341 cagcgccctc agcttcctct cggggctgcc cttcaaccag caatgagcac cctctggagc 65401 ttctcttccc tccgttgctc cttcaagcct ctgcccacct tcccctccac cctccgcctc 65461 tactgccaga gcttctgccc aggttgtcac cttcactggc tctgctacat ggaggaaggg 65521 agaaacgtat gaggcctgaa aagggggaca gggagaagta gcctgtctta tggccatgcc 65581 tcgagatgga aaacataaaa accaaccact ctcttggcag tgggaagagg acttgctgct 65641 ggcttatctt cggtagatgc caaaactatg tctgtccgct tcccagtcct gagttataga 65701 aagccttttt tattgttggt gggggcatta gttgtggaaa aattcatggg gtttttaaaa 65761 atctttggca aaaaagggtt cgtggaagtt aaaactctac aaactattgt gcaaagaagg 65821 acttctagtg tccgtttgct ctcttcatag taaacttctc agagctaagt tagttagtcc 65881 tatttccttt ttagctccct gaaggagcag tgaatattga acttctgtga agctccagat 65941 tctaagcttt tacttccgtc cctttgtcac ttcacgttcc aaacggaaat gtttgcttcc 66001 tagttcaagt gtcacttcat ttgtaaatat cccctttcct ggcaatgttc tcattaacat 66061 tggaatttct atttccttaa catgattact tctgatgtgt agatttttaa tcaccctcag 66121 gttatttttc agactttgat ggacactgga tgatcatttt agtggttatt ctttttcatg 66181 gaaagggaag ataattctct caagtaaagt cgtatttaga agttgcatca aagcacaact 66241 aaaatatgaa atctccaaga tgacaggcat gaaaagcaac cttcggagtc gcattagaag 66301 aatgtgccgg gctcagtggc tcacgcctgt aattccagca ctttgggaag ccaaggcagg 66361 tggatcacga gggagactga gaccatcccg gccaacatgg tgaaacctcg tctctactaa 66421 aaatacaaaa attagccgtg cggtggcagg cgcctataat cccagctact cgggaggctg 66481 agtctggaga atagcttgaa cccgggaggt ggaggttgca gtgagcctag atcgtgccac 66541 tgcactccag ccggggcaac agagtgagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa 66601 aaaaaaaaag aagaatgtac agaggtccat gcttattcta gctggggaaa ggcttttctt 66661 gttaaaacac acgtttgaga gaggcaagtg aatcaatcat tctaagtatc atgcacaagc 66721 tccctacttg agagatcaac cgcttagctg aagggagatt ctgttggggt cactcacatt 66781 ttgtagagct ttctgctgtt taggatgcat tttgacacac atgatctcat ttaacctgca 66841 tacaacctta caggtagctg gtgtctctgc ttgtaactga aaaacacaag gctatgtggt 66901 catttgccct cacacctggc aacatgtcag gtctggggtt caatcccaag ttcagcaacc 66961 cccagtacat gcctctgtct atcttaacat ggccaccctg acaggaactg acacctccaa 67021 atccaaatga gacctgatgg cttaaaatga gggttcggga aaagtagtag tgatgtcaaa 67081 aattactggt gctctggctc tctctctctc tgtctctctc tctgtcctta tatcttttta 67141 gcttaaaaag ccaataattg gctggtcaca gtggctcgtg cctgcattcc cagcactttg 67201 ggaggccaag gcaggcagat cacctgaggt caggagttca agaccagcct ggccaacatg 67261 gtaaaaccca atctctacta aaaaaaaaat acaaaaatta gccgggcggg gtggcatatg 67321 cttgtaatcc cagctacttg ggaggctggg gcagaagaat cgcttgaacc caggaggtgg 67381 aggctgcagt gagctgagat catgccactg cactccaggc ctgagtgaca gagagagact 67441 cagtgtgaaa aaaaaaaaaa agccattaat catttgtggt aagctccaca aggaagaatt 67501 tgttgcaatc ccacctgtgc ctggctccag caggtttcca ggaaacattt gttgcatgaa 67561 tgaacaactg aaatagggct tcccaggata taagtaagat tgcagagctg gacgccacat 67621 aaaggacaca gcagagtgca cacaacatac aatcagtagg ctgaaaaagg cggctcaggc 67681 aggcaccaaa gccgcactgg ccatacaaac aaagaaattc agcaaacaat gtggaaaggg 67741 gggggagcca aattccagaa atgcaaagac gtatcagagg cctgcaggct tacatgagaa 67801 ttcctggagc aggaaattaa atgcaagtta atgaagactt tgaaagcttt attcctgagt 67861 gcatgaaacc tgtgacatgg gtttggcagc tctttctgaa gcagagccat cgacgctggg 67921 gaagaacgca gggcacttgg catcacctag gagctttaaa aatacagatt ccagcctggg 67981 cacggtggct catgcctgta attccagcac tttgggaggc cgaggcagac agatcacttg 68041 aggccgggag tttgagaaca gcctggccaa catggcaaaa ccccatctgt ataaaaaaga 68101 caaaaattag cccggtgtgg tagtgcatgc ctgtaatccc agctactcag gaggctgagg 68161 cagaagaatc acttgaaccc aggaggcaga gggttgcagt gagccgagat catgccactg 68221 cactccagcc tgggcaacag agtaagactc catcaaaaaa ataaaaatac agatgcctga 68281 gctgcatgtc caggattgga ttggattggt ctggaggtgg cctgggcatc agtgttttta 68341 atgcctctcc ctcccttcgg cccagcaagt taagtctagt gaacactgac ttagaggtta 68401 gccaactcat actcctctat aaatgaagac acttgaggca tagaaggaga aagagccagg 68461 atcacccagc agatgagagg cagtggtcag aatggagccc aggaggccag tgctggctcc 68521 cgggccctcc ctctgaccct gctgccccag cccctggacc cctgcgggac caggctccta 68581 ggctcaggca gctttccttc tggctccccc ttctcctgcc tgcaggtcag catcacggtg 68641 atcgaggccc ggcagctggt gggcttgaac atggaccctg tggtgtgcgt ggaggtgggt 68701 gacgacaaga agtacacatc catgaaggag tccactaact gcccctatta caacgaggtc 68761 agtggccctg tggggaaagg agcctctgta aatatggcag gagggtggcc ccagccctcc 68821 ccaggagaaa taggagtggc tggaagtcaa ggagcacaca gggctaccag caggggtgat 68881 ccaccctgtt acaaccccca ggacactgac aaacagagcc acatcttctg aatcctctga 68941 accccccagt ctagagcaca ggccgacact ggtctttgaa gcgtacacca cccgggtgct 69001 cctgggcaga ccccagcagt gcctgtgaaa gaaccccccc ccaccccact ccccaagagg 69061 cctggttccc actgtttccc aggccagagc ccaaggacag ggctgcctca ttccaaccca 69121 tggtggcact ggcaccatta gtaagcactt tctaccagcc aggcatgctc ctaaatgctt 69181 ctgaactgga ccatccaaag ttgtcactat caattccctt ttacacaagg ggacagtgag 69241 acttctgaag gcagaccttg tccaacctca cagtgccagc atcgcccttg gcgtgctagt 69301 ggggttctgc cctcttggct cggctccttc atggttgcct aaacttctgc gggcttctct 69361 ccagagcact ggccttgatt ttagggtgtg aaagagaaaa catttggtac ccactcctat 69421 tctttccagc catttgaggc cacatcaagg gtgagggacc tcagagacct tctactttaa 69481 tctccccatc ttacagagga ggatactgag gcctccatat ggaagggcct tgcccacaat 69541 ctcagagagt gttgctgata gagcaggggc caggctgccc acccagcttc cagcccaggg 69601 ctctggccac catcacaaat atggcacctt ggttcccagg ctccagatgg gaccccatca 69661 taatcagctc tggggaggga tgtgagaaat agagaaatac actcactcat caaaacccaa 69721 agaatgactt agaggcatga agaacagcga aagtgagact tttaataacg gtcttgcaag 69781 atggagtgtc tggtaggcag gcacccctgg ggcagtcaca acaggaattt atctcctagt 69841 gtgcaagtcc ctcccccact tccccattgg ttgagcacta tggggttaca atcttccctg 69901 acgtcgccta agtttcattt tcccccttac aaggttatac cccgctcccc ttcgatttcc 69961 ccacttaagt ttcgatttcc caataacaaa actttcttcc ctttcatggg ctgacccctc 70021 ctctacattc tgttcgctta ttgtgtcctt ctaggtgcat gagccgtgtg gtttgttgca 70081 ttcgcaggtt ggatgccagt acttagactt atcctgcctt gaaaatggac cattgaaaat 70141 gttttctcac caggatgccc aggcctttcc cagatgcctg atcacacatc agactaaccc 70201 agaagccaca ggcctgggcc ctgccatccc tttcctggag ggttccccag tctgtttctc 70261 ctggtggctc caggcagtga ggggtgccag gctgtcccaa gtaaggcagc tgagtcccgt 70321 accctgaggt gggtgagggc tgaggtgccc cctgtagctt gggggagggc atttctcagg 70381 cagctctgag agtcctcaga ctgtgcacct gcaggaagaa aacccaggcc cacctctgcc 70441 cttcagccca ggcctggccg aactctcctt tgtgaccaca aattgactct gctctcccag 70501 ctgctttccc acaggccccc cgagctggac aacctgctca ggacccctcc agccccaagg 70561 acattcagga ttgacatctc tggccttacg ttaggacaca tcctgactgg acaagtctcc 70621 gcctagataa gcatctatgt ccccaagaca ggcatggaga caggtccctg tggccccggt 70681 ggttacttga tagcagtgaa gccacttctg ctaacttaag ggatctccct ccaccaggcc 70741 cacacacctt ggctttcatt caaattactt cctctttccc aagggcacag agctgctctc 70801 cctactctgt ggctccccca gaaaactcct actcacccgg cagggcccag ctcaaatgtt 70861 cttgctactg agcagccttg cctgctctgt ctgggtcaga ggtcagcact cccctttctc 70921 tgcagtgtta atgtcctgga gttgaggttg gtcctccgtg tctctgtcct gctggtggac 70981 tggaggctcc cagtctcctg cctcgctatt tgttcagagc caggcatgta ctcggagggg 71041 ttcagtaaca ctcacccaaa ggaagacaca aacatccact gagcatctgc cgcacaccag 71101 acagtggcac gtggggcaac atggaggctg ccgagatgaa ggaggcacag tttccgccct 71161 gcgcaggtcc cctccttgtt tcagcctaga atctttctaa attccctatt tacttcctct 71221 aagactgact attcattctg ctcatctttg gacaatctta aatgtgtttc tgatcacatt 71281 tttgttcttt ttcacaaacc caaatagctc tgattttgtt tctgtttcct ctaaactagg 71341 gtttctcaaa ctcagcacta tggtatcttg gactggataa ttgtggtggg atcgtcctgt 71401 gctgtgtagg atgtgagcag catccctggc ctctacccag tagatgccaa tagcaactcc 71461 ccttagttac agctaccaag tttccagaca tgccaaatgt cccctgaaat cgccctcagt 71521 tgagaccacc attctaaact atcttactat gattccttcc agccccaaat cagcctttcc 71581 agccccaaag ctttgtttcc cttttcttct ctttctatgc cacattcctt ttcaatgaag 71641 gacatcctcc tcgtcgtggg aatgtattat ttctgactaa ttatctgagc tggtaggaac 71701 cttcctttgg ctccattaaa acaacagagg gaggtgggaa caatcaacat gacttaggta 71761 tctaagctat tacaaaagga aaatatgctc aggaaataac aggaatttga ttgcagacag 71821 ctcagagagt tcgggattct ggctctagct cagctagctc gctcccctgg ggctggcaca 71881 tctgcgggca cctggcctga tcaccctgcc tggccctgag cctgcctgtg tgcagggaag 71941 ctcaaaacct ttgcccttcc ggaacaagct ggccattcac aaaccagact aaggctcctt 72001 tcctgtgtgt cctgtgtgtg catctggccc cgccctgggc atcttgggag cgccaccatc 72061 cttcctcctg ctgaaaatcc acctctcccc tttgccttgg atccttctct ttctacagct 72121 caaagaacct ggcattgcac agcccaactc tgtctttgtt tttcttccag ccccttcttc 72181 cttgcctata aggtgttcta ctccagcata tgctaagtac aaccatgaag acccatgtgt 72241 gctcaaggac aggaactagg agtctgtcac ctctctctgg gcctttcctc attcccacac 72301 acttctccag tgacctcctt tttccctcca cccctccaca gtcagaccac ttgggttgtc 72361 ctcacttcct ccccccagtc acccctcaat ctctgcaggg tttctgcctc cagatgtcat 72421 tgacactgct ctcctcaagg tcaccaagga cattgctgtt cctgagtata atgtccatgt 72481 catcctcctc tcccttgatc acccagtttc tttcatcccg ctgcctgctg ctcctcttgg 72541 gggcccctca cgccactctc ctgcttcccc tgtctctcca gctccatctc cccggcctaa 72601 cttcttggct gaaaggctgt gtcttcttgg agccctgacc tgggcctgct tcccctccca 72661 tgctctcccc aggtatctcc tccatctcca aggtgtcagt taccatcttg tgctgacgat 72721 tcccaaatcc atatccccac ccgcctcccc agagcttcag aactctggcc agcacaccct 72781 gggcctgtta gtgtcatgca cagctgtcgc tgcttgctat gtgcttaccg tggtgcacac 72841 ctgtgttaaa gacttgacca gggtgtctca ttgcaacttc acaaccacac cttgaagccc 72901 cccaagtgaa tggcacccct ggagcagttc agcacgacag ccctggatca tatctccaca 72961 ttcataggat aataggtaaa ctgaggctca ggcaagaaag tgagtgatct agcagtaaca 73021 gccaggtggg gctggctctg aagctggctt taccctcagt gctcaagggc cagcccccag 73081 cagccaggag cacgttctct tcggacattt accccaagca cattggaaat atttctccct 73141 tctcccccac cacagttcac caaagcagca gcccctctac tcactgcccc acaccctcat 73201 cctcagcacc tgcacaccca ggccagggga agagatgggg actgcaaatg tgcatggcag 73261 cccacagcac caaaggacag tgcacaccca tggcatttca catcgactgc caactaagtg 73321 cttggcacac catggttcat ctgctctgag gcttgcgtta ttttacagtt tcacctctct 73381 gaatttggga tgtgtctcct aggcagcctt gtggcttcat ggcaatgtcc atgtggctta 73441 ttaaaccgta gtatatctta cagccagtag ccactttaga tttggtaaaa tatgttacac 73501 tgtctcatca gagcctcata acaagactct gaggtgggtg tcattatccc catttcacag 73561 ctcaaaaaac tgaggttcag agaatgtgtt gctcaaggcc acacagttaa gaaggtgcag 73621 agcggggact agaacccagg tctgcttgct ccctggccct gtgcctcttc tgagcacagt 73681 acaagggcat gggctgtccc acctactgtt ccaagttcct ttcccacccc acactagcca 73741 gcaccagccc cacctagggg atggggctct gcttcctacc acccaccacc agggtcaatc 73801 aggatcagat gagttgcctc tgctgctcct ctgaactttg gggctcaggg caaatgtctg 73861 gggtgcagac aggccctgcg aggagggagg ggcccaacac tgcctgggct gttgctgctg 73921 ccctcagtga cagcaggcct ggatccttcc ccctccagta cttcgtcttc gacttccatg 73981 tctctccgga tgtcatgttt gacaagatca tcaagatttc ggtgagtggg gagcagcccc 74041 tggccggcag ggccactccc tcaaactgca cctttgtgca gacttgagag gggccccctc 74101 tgtctagacc catgataaag aggcagcgcc gtgcctggac acacggctgg gcaagtaggg 74161 acaggctgga ttctggcccc cacccacccc tttcattgga tgcctctgaa tagtgcattc 74221 gcccgtaaac agtggccagc aagaaactgg cgtgggcagg aggagctgat gctgagcctc 74281 agtgagccac cccactctgc caacgccctc ccacttcacc acaaagctcg ggtcccacca 74341 ctgccccatg gaaagcctca cccttgctgg gcctgacggg tgggctgtgg ttctgcctga 74401 aaggtgattc actccaagaa cctgctgcgc agtggcaccc tggtgggctc cttcaaaatg 74461 gacgtgggaa ccgtgtactc gcagccaggt gagtacctgc gcatggccag tcagtcgagg 74521 tgtgcatggc tcagggagcg tggtgcacgg ggcccttccc actgtggcag ttcctgggaa 74581 aaggctggca aggaccacag tctggcgact gttagtacac acagccatct ggcctgcgga 74641 gaagtggcgc gcacagtctg tacacaaatg cagtgagcaa ctgcgcaccc agtctggtgg 74701 gttctcactc ataattaggt gagtaactct gcacagagcc tggaaggagc ttcatcacac 74761 gctctggagt gcatggcagg ctggtgcatc actggccata ggcaggctga ccagtagtgg 74821 tagaggatgc ggtgagggag acccgtcaca gcctgcagag aggctgcgcc cagactcctg 74881 cctcctgggc tggcacctgc tgagcagaaa agaacccctt tccacccctc acaggaccct 74941 gccgtcccct tttacagttg aggctcagag ccagggcttg ccccagccac acagctggcc 75001 gggggtgaag tcaggctgtg tgtccccaga gcctcactga gccacactat ccaatctgaa 75061 aggggtgatg ctggtcaatg ccagatgtag tgcggcggcc tctgagggac tctggtctct 75121 gaaaacactt cttacaagag ccccaggctt ttgggcagcc atgtgtgctc cgtggcgtcc 75181 tgtagggtaa cagcaatggt gttggcaagg gaaccccaag gggtggccca gagggcttgt 75241 gaggtgggcc aggcagagga agtgcctcag cctgccagat gacagctcac cacgtgggca 75301 ggttagggac caccctgtgt ccctgaagtg aatgcactgc tcagagtgct gtaatgaccc 75361 cattaggcgc tttgacagtg agaacataat ttcacccaat tgtcacattg ggccctcaca 75421 aaacagtaat gtaggcagca gcatttcttc ccattttgca catgagataa atgaggctaa 75481 gagaaatgaa ggggcttaga gataccacta aactagtagg ttgaacaaat tggcgatcgc 75541 ttgtggttca acctaagaga cgtccagctg gtgcacatta caactatgac ttagaccagg 75601 gaatctgagt ccaaaaccaa gattatacac ataaaaatca caagatcata gaacactcaa 75661 gctgcccaag acctgaaaaa catctagtcc agcctctgtg aagataaact gaagcccaag 75721 gtgatgaagg ggtttgtcca ccatctagga gtagcacccc tgtctccagc tcccaggcca 75781 gtgcctttgc caccacccca cacatgccat agccctcagc ggagggcagc cctgctgacc 75841 atcagtgcca tggggagcag ggaagagtcg gcctcctgcc atgttgcttt ccaggaagca 75901 tgcatagccg tggactactt gcttggaatg actggcatcc ctgaggataa gctcctccca 75961 gggctgagca gtggccctgg taccactggc aggcctgagg ccgagagcca agagaaagtc 76021 agggggtgga gaaaaaggca gatattagtc taatatggac ctctgggctt ctgggtagta 76081 aagtcctggt gaggaaacca ccagggcatc agtaagtgcc agatgttggg ctaagctcac 76141 tgtcccagca ggcctcaccc tcacgacccc atataggcat cattcccatt tcaccataag 76201 gaaactgagg ctcagcaggc ttaaacagct ggtccagggc cacattgtga gtaagcggca 76261 gaaacaggat gtgggccgag gtctccactt gggtaaccta gctcgagatt tgctgcttct 76321 gctgaatcca gccctgagcc tggtgccctc ccagggacag gagagcctga agtcacatgg 76381 gtcctggagt tgagacccaa tgtctttact ctgatatctc cagtttggcc tgaacttctt 76441 gatgagtcgt tggttccagc cagggcattg ttggacagca tgctcccaga gacactcctg 76501 ggtgctgctg ggaagctttg ggtggtgtcg atatctcttg gaactggaag gggtttcccg 76561 agagaacctc ttctcaccct ggcaggacca cattttgtca tttgtaccac cagatgcaac 76621 atcaggaaac tgtttactgt ttgctactct ctgttggggg tgaggacggg ccatacactc 76681 atcctcatag atcatagagg aagtcagggg catacactca tcctcataga tcataaagga 76741 ggtctgggat gcagcaactt ccccagctgg gctacccttg actggcaggt gtcagcccca 76801 ggctgaaggg aggtgaaatg atgtttcagg ctggtaagca tatagctcag gatctcatgt 76861 ggtccttgta tctctagcct gagatcacac agtattagga ctagaagggc ctcagaagtc 76921 atgagtcaag tgttaacctg atgtagggac ccccacagca ccatctctga ttggtcctct 76981 aaccttgctt agtcctccca gaaatggggc actcactact tcttatttta gatatcttca 77041 ctttctttag gtcatctcaa aatctgtcac cctgtaacct tcacccactt tcacacgtct 77101 ctctttcagg acaaaaagaa aaatagcctt taaatttgaa ggtaaatttt acattcctcc 77161 tgaaccgtat tctctttctt tgctaaatgt ccccaattca tctaaccatg cacacctcta 77221 tacatctacc cctgtatcca tccatccact cacccaccca tctacaaatc catccaccca 77281 cctgtccaca gatccaccca cccatccatg tatccatcca ttcacgcacc aatccatata 77341 tccattggtc cacccaccca cccatccgtg aatccatcca cccacccacc cgcctgtcta 77401 cagatccacc cactcaccca tatatccatc catccaccca cccacccatc catatatcta 77461 cccacccatc tatccacaga tccatccacc tacccaccca tccacagatc cacccaccca 77521 tatatccacc catccaccca cccatccata tatctaccca cccacctgtc cacagattaa 77581 tggctccttc tatccagtaa tccattcacc atctgtccgt ctatctctca gccggccagg 77641 cagctcacca cccatccctc tgcccattta tgcacccatt cattgagctt tctgtccatc 77701 tcctcatccg acacacatct gctctggcaa gacctgaagc tcctgggatt cctgggacat 77761 ggcccctccc tggaggcctg ccagcctggc tgaggttctc cagtgactcc tcatccacgt 77821 gccttcctgc cctctcacct tgcttgtccc tctcttcaga ctctactgtg gcattatctt 77881 ttctgagaca caggtggcct ggctattccc agaaaggcca acctctgtac acagccccta 77941 acatctccgg gagcccacca gggccacagg cttgcaggac acaggcctgg gctacggtag 78001 aaggtggaag aggagggagt gaaggaggga ggtgctgagt ccctgagagt tcagtgccca 78061 cctaacatcc cgggaagcag attcctaagg cacagtgatg cgcttccctt tgcttgccca 78121 ctgggcttaa agtaaacctg aaggggcaaa tccttcctaa agcgcctcct tccctgacat 78181 ccgtcctttc ctccacacag tcataggtca tgggacactg ggatgagact gacaatccct 78241 gtctttagga gactctcagt ctaaaatcag agccaaacaa tacccagatc agcacagtga 78301 gatgggaggt gtgcatggag agcacagaga acaaacacta aagagcccag gatcaactct 78361 tccgaggaag tcagggaggg ctgcatggag gaggagagac ttgagcaaaa tgagtagaag 78421 tttacaaatt gaatagggag aaagacaggt ggaggtggag agaacaggaa tgagggcatt 78481 ccaagctcaa agagcagcag atgcaaaggc atggaggtat aaaagggcat ataaaaccgc 78541 aacacctgtt cagcaaggag gaacacaggg ctgggtgggc tcagcagagt gagtcaggga 78601 gcactaaatc aggagcctgc aggccatgcc ttttgtcttc accccaaggc actgggaagc 78661 cccagagggg ctgaagatgg ggagcaggag catgagcctc cacctgggaa ggccctgtgt 78721 gcagctgtgt ccttcacagc tatgtgaagg ctggctgact ggggtggggc catagaagag 78781 gccacaggca gaaaaaccca attaggagga ggctgtcgtg cttccaagtc acaccactca 78841 tgggatatat gtccatgggc aggccatgca cccactgccc cagctccaga ggacctcaga 78901 ctctatcaca ccctgggcta gggacaggca gagctgtggc cccaggtccc gggactctag 78961 ggaccaagac agcatttggt tctgccaccc cttggcctgc cctgagcact gggagacgct 79021 ctgggtgggg gtgtctggtg cagtgcccac ccctcatcat tgcagagcac cagttccatc 79081 acaagtgggc catcctgtct gaccccgatg acatctcctc ggggctgaag ggctacgtga 79141 agtgtgacgt tgccgtggtg ggcaaagggg acaacatcaa gacgccccac aaggccaatg 79201 agaccgacga agatgacatt gaggggtgag gcccagctac cccagcccct ggagtctgag 79261 ccagcccttc cttcccccag ggagcccccg gtgagggttt gctgagagca cctgccaccc 79321 gtctccctca ccctgctctc gctcactctc ccaagcagcc ccactcttcc gaggcagggc 79381 aggggcaggg ggtgatggag gatggctgag aatatcagtc ctttgacatc ctttctgcca 79441 gtgagaaatg ggttgagaag agtcgatgct ggcagaccag aaccagcagc tgctgggtcc 79501 tgagtatagc agcaggaagt gctgggagag ccaaggtttc ttctggtgtg ccaattccag 79561 gcagctgata gcagctgttg agaaatattc tgtgaccttg tctggagtca gtgggtaaaa 79621 gtgctgggaa tcaatgaatc ctgtcttttg tgagctgggg gagagagagt ggctactgtg 79681 aagtttttgt ctacgaaaca aaagatacgg cacaaaacta taaaacactg acaataatac 79741 taagatcata tcccaatgta caatctacaa agcactcata tgttttagcg tgcttgagcc 79801 gatcatgttc ttgggaggtg ggtattatta cagccacctc aacagtgagg aaacggcagc 79861 tcagtgagat gggaagattt gcccagaatc ccacaagggg caagttccgt gaacacaagt 79921 gtctaatcct agccttgctc cctcagctgt cccttagaga ctgtgccagg acccaggagt 79981 gtgtagatgc caggatgggg gttggggacc tggacctggt gaccatggcc ctggctgtat 80041 gtgctggcag gaacttgctg ctccccgagg gggtgccccc cgaacgccag tgggcccggt 80101 tctatgtgaa aatttaccga gcagaggggc tgccccgtat gaacacaagc ctcatggcca 80161 atgtaaagaa ggctttcatc ggtgaaaaca aggacctcgt ggacccctac gtgcaagtct 80221 tctttgctgg ccagaaggta ctggggtatg aggtacagga ggctggggct gggtgacagg 80281 tatcacaagg gcaggctgat gggtgtgggg cctggggcag ctgggcaggt aagacaaggc 80341 tggaaatcat gttggccagg gacggactta gaggatcctc actgcctcct ggagtcctta 80401 gactgagagc tgcgcagggg gcatgagagg gaggagaggc tgggggtgtg ggaagagtgg 80461 agacaagtcc acacacaggc acgcacacac acatgcaccc actcatacac gcacgcatac 80521 caactcacac acgcacgcat accaactcac acatgcagac acgcacccac tcacccgtgc 80581 acacgtgcac ccacgaatac acacacacat gcacccattc acacacgcac acacacccac 80641 tcacacatgc acacatgcac ccactcacac acgcacacac acccattcac acatgcacac 80701 atgcacccac tcacacacgc acgcataccc actcacacgt gcacacatgc acccacgaat 80761 acatacatgc acccactcac acgcacacat gcacccatta acacacgcac acatgcaacc 80821 actcacacac gcacacatgc atccactcac gcacacatgc acccactcac gcacacatgc 80881 acccactcat acacacacat gcatccactc acacacgcac gcgcacccac tcacacatgc 80941 acccactcac acacgcacac atgcatccac tcacacacgc atgcacaccc actcacacat 81001 gcacacatgt gcccactcac gcacacatgc gcccactcac acacacacac atgcacccac 81061 tcacacacac atgccacgcc ctcacctgtg ctcccccttc caccagggca agacttcagt 81121 gcagaagagc agctatgagc ccctgtggaa tgagcaggtc gtctttacag acctcttccc 81181 cccactctgc aaacgcatga aggtgcagat ccgagactcg gacaaggtca acgacgtggc 81241 catcggcacc cacttcattg acctgcgcaa gatttctaat gacggagaca aaggtcagca 81301 gcgggagacc cggtgtgctg gggggcagag ggagtggcct gaagggaagg aatatgtgag 81361 atgccctctc ttcacaccac cgtcatcagc tctggtcctc agcctcacag gtgcttccag 81421 ggccttgcca gcagcccctg cctcaggggg agggtgagga tttgtggctc aggtcggctc 81481 agagctggcc tgagcccagc tgactggatt tgtcagctag tagttgtgtg acctgttttc 81541 ccatttgtaa agtgaaaata ataatgatta tatgatatga taattatagt atgatatgca 81601 cattatagca gtgtatatac tgcatttgta tataattaca gtgtgtgtgt atatatatat 81661 gatacctaat agtagtgcct atctgcagaa tcgcagggat tgactacctc ctaggatccc 81721 tgccctgtgc tgggttccaa ggacatagag tgagataaga atctattcct ggatcaaagt 81781 gctcactgtg tattgaggag atagatgtgc taccaaatgg tcaaaacata aggcagaaga 81841 cacaaaaggc cacatgttgt ctgatccatg tatgtgaaac atccggcaaa tccacagaga 81901 cagaaagtag attgccggtt tccaggtgct aaagggaggg gattgggact aactgctaaa 81961 taggtgcaga gtttcttttg agggggtgga actgctctgg aagtagatga tggtttatag 82021 cacagtgaat atacgaaaaa ccactgaaat gtacacttta aaagggtgaa ttttatgtca 82081 tgtgaagtat atctaaattt ttaaaatgct ataagtgtgt tttttaaaaa aaggcagaat 82141 aaaaaggaaa tgaaccaaaa aaactggatc atgagacccc tgtcagaggc ctgacaaatc 82201 ttagccataa gagaagggac ttgtgcctag gaattgggaa ggcttcgtga ggaagcagca 82261 tttcacaggc agagatggag agggatggcc ttcagcaagg aggggagggg tctgcactgg 82321 cagggtcacc gtggtgggac agagctgcaa aaatggcaca gggcccaagg tcatgctgcg 82381 gacttggaag gactggctct gtcctacaag tagactgttg acaattcctg ctctaagttc 82441 caggaagcag ggagctagac tttgccttcc cactgcttcc agctcaggcc cccgcaggga 82501 agaaatagac ccaagagagt gctccacccc agcgcagtgt aagaaggctg ccccacacct 82561 gaatggcaca catgaagttc tcagctcagc acccaggagc tggaggccag ggacccccaa 82621 aagaggcccc tcttccccag ggaaactgga tgtgacgctg ccccctcatt tttgttccca 82681 ctgccacagg cttcctgccc acactgggcc cagcctgggt gaacatgtac ggctccacac 82741 gtaactacac gctgctggat gagcatcagg acctgaacga gggcctgggg gagggtgtgt 82801 ccttccgggc ccggctcctg ctgggcctgg ctgtggagat cgtagacacc tccaaccctg 82861 agctcaccag ctccacagag gtgcaggtgg agcaggccac gcccatctcg gaggtgagac 82921 cccaggcact gtgctgtccc ccagggcctc cagctcagcc cccttctccc tgagtcacct 82981 gggtcccagg ctttgcctgt tgctgccctg tctacctgag gagtcatacc tcaggataag 83041 gcttctcccc aggaagcaga ggcccccact cagccccgca acaggactct gccctcgtcc 83101 actgcctgcc tgtgctctgt ctcacaacgg ccgccaggtc tcacgatggt gcctcccctc 83161 tgcccctctt cccagccacg gctgtccctg tggtgtctgc agccagccct gcttccatgg 83221 atatccaggc tggggggccg ttggggtgtg ggctgcctgg ccccaaagcc gggtgggatg 83281 cccccaccat ccacccccac ggcctgtctg tgagacggaa ggaggcctgg cccccgacct 83341 gccaccctta ctcaagctca ggaacgcttt gaactgcctc cccacagagc tgtgcaggta 83401 aaatggaaga attctttctc tttggagcct tcctggaggc ctcaatgatc gaccggagaa 83461 acggagacaa gcccatcacc tttgaggtca ccataggtga gtgctgggcc cacgggggct 83521 tcgggcctag gtgagtgctg ggcccacggg ggcttcaggc ctaggctgca ggtggtaagt 83581 gtgaggctct gcacctcagc cctgtcctca ctcttgtagg gaacgttgac ccctttcccc 83641 tgagaggcct caagcaccca caaaacacct ttgtgtgtgc atggggtgga ccacgcccca 83701 taaaggggcc aaccctcagc tccacctaca gggtgaggct gtgtttggga cctggggcag 83761 agggcaggga gaagcccttc ccggggctgg agaggagaga gtgggaactc aggccacagc 83821 ctgggccagg gctgggcctc gcactcaggc gtcatgagga ctccctgact ctcagcggag 83881 tggggacacg ggctaatgct ctctggctaa tgatgtgtca cgtctgagcc ccattccctg 83941 actctccctc tcccctttcc caaacccaag gcagcaccgg attggacggt gggaggggcc 84001 tggtggggaa tgcactctag gccttctggg cccattctgc tccaggcaac tatgggaacg 84061 aagttgatgg cctgtcccgg ccccagcggc ctcggccccg gaaggagccg ggggatgagg 84121 aagaagtaga cctgattcag aacgcaagtg atgacgaggc cggtgatgcc ggggacctgg 84181 cctcagtctc ctccactcca ccaatgcggc cccaggtcac cgacaggtgg gcccagcctc 84241 ccatcctcct gtggcctggc cctcccacct ccctgggccc ccaagacctc acctcccgcc 84301 tctgcccacc ccaggaacta cttccatctg ccctacctgg agcgaaagcc ctgcatctac 84361 atcaagagct ggtggccgga ccagcgccgc cgcctctaca atgccaacat catggaccac 84421 attgccgaca agctggtcag ggccaggcca ggggccagca ggggtggggt cctgggggag 84481 acggcgctgt cagagggcct tccctggaac acacaaagct ggtctgccca gggggctgca 84541 ggaacggccc cagcaggacc tctgttccca ttctcagccc caggtcccag ggcacagaca 84601 aggacaggag ccacctctag tcactcagcc tccagtgaat cctggggcag gagtgttggg 84661 ttccctgatt tttccagaaa tcttaaaagc aaggctaggg agacaggtgt ggtggctcac 84721 gcctgtaatc ccaacacttt gggaggccaa ggcaggtgga tcacctgagg tcaggagttc 84781 gagaccatcc tggccaacat agtgaaatgc cgtctctact aaaaatgcaa aaattagcgg 84841 ggcttggtgg cgggcacctg taatcccagc tattcgggag gctgaagcag gagaatcgct 84901 tgaacccgtg aggcggagtt tgcagtgagc caagatggcg ccactgcact ccagcctggg 84961 caaccgagca aaacttcatc tcaaaaaata aaataaaata aaataaaaca aaataaaaaa 85021 gcaaggctag ggaagggaaa tggggaaaag ggagaagcga gcagtgtctg aagctcagga 85081 gctgccccct cctcctctgc ccacccctct ccccccatga gccatgggca ctgactgggc 85141 gaggagtgca gctgttggca tgagacctcc ttctccccag cctggggaag cagggaccag 85201 cagataatcc cgcccttccc tgagctgttg ctgttccctg ttgaagttcc ctgaagctca 85261 gccagctcat attttataaa aatgaattaa aacctccaaa aaaatcaagg ctaatatgag 85321 gtctgctccc agccccctgc caatgtcctc cttgtcatcc ctgtcttgtg actataacca 85381 caattaaagc ccatagcctt tgcagtgtga cctgggtctg cagttatctg caaggcttcc 85441 ccctaaggag ctggggtaca agctgacctg tgtttcctgt gggacctggg tctcacagcc 85501 ctcccagtgc tctcagagcc agagccactc cctcttcccc caggcatctg ttcccatccc 85561 ctgccacagg ctccagcatt ctggagtgac gtcaggatct tggcacatcc agtcctaggg 85621 tttccctctg tctctggcca gccctgagcc ccgtagccgt gagttctgcc caggccctgt 85681 gagctcacca gagccacaga ctcacagccc agaggtggct tcttccttca ggaactgaag 85741 aacccccatg aacaccaaca tctccaggtt ctgagaacag aacctgggaa attgatgact 85801 tcctcatgat gaccgatact caggatggcc ctagcgagag ctcccagatc atgaggtccc 85861 tcactcccct gatcaacagg gaggaggcat ttggggaggc tggggaggcg gggctgtggc 85921 ccagcatcac ccacactcct gattcacagg aagaaggcct gaacgacata caggagatga 85981 tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct 86041 gtggctgctg gtgagaaggg aggggcggca ggtgggggga ggatgaggcg gaactggaca 86101 aaggggaccc tgccagggct gggcagatga ggaagaatct acagagcccc tgctggtcag 86161 gctcgctaaa ccccggctcg ccctaccccc agccgcttcc tctccctcgc tgacaaggac 86221 cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg catgagggag 86281 ctggtgagga cgcaactgga cggcgggggc tggagggagg gcctggttgt gagaaggtgt 86341 cacaaccccc tttgtcatgg cccgagctgt cccccagttg ctgggttcac tgacaccccc 86401 tccttcgcag gaaaacatgg ggcagcaggc caggatgctg cgggcccagg tgaagcggca 86461 cacggtgcgg gacaagctga ggctgtgcca gaacttcctg cagaagctgc gcttcctggc 86521 ggacgaggtg cggcccaagg ggtcggggct ttgcctcatc cagggctggc tctctggggc 86581 ccctcaggat cagggggctc aatcaggagg ctagaccccc ttacccactg cccctggcca 86641 ccccccaacc cccagcccca gcacagcatt cccgacatct tcatctggat gatgagcaac 86701 aacaagcgtg tcgcctatgc ccgtgtgccc tccaaggacc tgctcttctc catcgtggag 86761 gaggagactg gcaaggactg cgccaaggtc aagacgctct tccttaaggt gctggagggg 86821 gcaggatgga tgggggcctg ggtcctttca ggggagcagc agcccccacc tggggctgga 86881 agcctgagtg acagggtggg gccttcaagc agcaggtgct cagagaagag ccaagaatgg 86941 gaaggacgtg ggggaagggg tggggaagga ggtgggggaa ggggtggggg aaggggtggg 87001 gaaggaggtg ggggaagggg tgggggaagg ggtgggggaa ggggtgggga aggaggtggg 87061 ggaaggggtg ggggaagggg tggggaagga ggtgggggaa ggggtgaggg aaggggtggg 87121 ggaaggggtg gggaaggagg tgggggaagg ggtggggaag gaggtggggg aaggggtggg 87181 gaaggaggtg ggggaagggg tggggaaggg ggcatgacgg ccccctgccc atcctcctgc 87241 ctccaccgga ccccagccca gcgggatggc tgtgaagggg cagggcagct ctgaccaggg 87301 cctctgccgg cccctgcccc ttccccacct cttgggccct ggcagccgtc aggctcctgg 87361 tgaccccatg cccaccccca gctgccaggg aagcggggct tcggctcggc aggctggaca 87421 gtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc 87481 ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat 87541 gccttcccac ccgtcagcct ggtctacacc agtgagtgag gacccctcac tcgaagcctc 87601 acctgggagg gggccggagg ggctgcccat cctggaacct caggctgccc ttccccacag 87661 agaagcaggc gttccagctc cgagcgcaca tgtaccaggc ccgcagcctc tttgccgccg 87721 acagcagcgg actctcagac ccctttgccc gcgtcttctt catcaatcag agtcagtgca 87781 cagaggtgag ggcctgggag gagggagtgg ctctggcttt gagagcacca gaagcctgtg 87841 agcctgtggg gactggagcc tgtggggcct gtgagcctgt ggggcctgga gccacaggtc 87901 agccagtgcc ccggtttctc aggggaagcc ctgcagataa ctgcagcaga cgcgggtcac 87961 actggaaagg ctacgggctt tagctgtggt tatattcaca agacagggac gacaaggagg 88021 acattggcag ggggcttggg ccaaacctca tattagcctt gattttaaga tttctggaag 88081 aatcaagaca cctgtcactc ctgcccccag gttccgtgga agctgagtga gtaggggtgg 88141 cttctgtttg tgcatctgcc cccccctctg tcacttgtcc cctgtctccc catcccatgc 88201 tgcaggtgct gaatgagacc ctgtgtccca cctgggacca gatgctggtg ttcgacaacc 88261 tggagctcta tggtgaagct catgagctga gggacgatcc gcccatcatt gtcattgaaa 88321 tctatgacca ggattccatg gtatgggtgg gctctggtgc cagggacccc agcagcacca 88381 cacctggccc ttgttccctg cactccacct gcgctgaggc tgtgccctca cctccgccac 88441 ccacctgcag agctccttgg ccaggtgctg gctgggaagc tgggagtggg ggctgacatc 88501 tagctcctcc tgcctgcttg cggcagcctg accccttccc aggccagcac atcctcacct 88561 cctgtctcct acagactgag ccctggaggt gtgccagcaa gtcctgctgt cactagcctc 88621 cccaccccag ggctccccga cccctgccct cacctaccac aaccagtaac agccttgcca 88681 tcctccgtgg aggttctgga gcagggagta agggattggg gtgacccccg agagttagcg 88741 agccaccttc tcacatacca cctcagctgc tgaggtgccc agatagccct ggactagagg 88801 taggaggacc tcatgtctag tcctgagccg ggcatctgcc atttactgac tgcttggcct 88861 tgaacaagtc tttggtgggc cctgagactt ggtttcctca tctgtaaaat ggggtgatca 88921 cacctgtccc ttacaacaac tcatggcgct gtggtaagga ccaaacgaga tcacaggtgt 88981 ggacagcaag caccaagagg cttctgggtt gtctgttgcg tcagggcaaa gctgacttca 89041 tgggccggac cttcgccaaa cccctggtga agatggcaga cgaggcgtac tgcccacccc 89101 gcttcccacc tcagctcgag tactaccaga tctaccgtgg caacgccaca gctggagacc 89161 tgctggcggc cttcgagctg ctgcaggtgg gactgcaggg aagaggggct gaggcctggg 89221 gactggaggc tgggagttgg ggcctagggc tgggggctgg accctgaagg ctggggcctg 89281 gggtctgggg cctgggggtg gggcctgggg gctggaggct ggggcctggg gctgggggct 89341 ggggctgagg gctggggcct ggggcctggg gggttagggc ctgggcgtta ggtcctgggg 89401 gttggggcct ggagctgggg cctgggggct ggggcctagg ggcctctctc ctacccatcc 89461 tgaccaaagc tgggggcgtg gtccttaggg ggtttccctg tctccccaga tcatggcaaa 89521 caactcatgg ggaaagagac cctgtccctg ggctccccag tgtgtgacct gtgaccccca 89581 ttccccagat tggaccagca gggaaggctg acctgccccc catcaatggc ccggtggacg 89641 tggaccgagg tcccatcatg cccgtgccca tgggcatccg gcccgtgctc agcaagtacc 89701 gagtggaggt gcgagggctc tgtgtggccc ttcccttttg gatgaggagt ctgaggaccc 89761 aggaggggaa gtggcttgtc atccccctcc caccaccatc accaggagcc agcagcagac 89821 ccaggctcct gccccagccc agggcctgcc cccatctgca ccaagtcgca ctcccatgtc 89881 ccaggaccat gcccagccct cctgtctgca cccctgaccc tgcacccctt ctccgggcag 89941 ccccaccctc atccctggag aacgcctgcc cctcctctgc tctcctggcc ctgctcccac 90001 cctttgaaat ctggggtgaa ctactgccca tcccactgcc cggttcccta ttggatggtc 90061 cagcaccccc atggctggct cccttgacta aggggctctc ttctctgcac ccaccctcca 90121 acctctccca ggtgctgttc tggggcctac gggacctaaa gcgggtgaac ctggcccagg 90181 tggaccggcc acgggtggac atcgagtgtg cagggaaggg ggtgcagtcg tccctgatcc 90241 acaattataa gaagaacccc aacttcaaca ccctcgtcaa gtggtttgaa gtggtgagtg 90301 caggccctgg cggaggacat cctgtggcca gtgtggctcc actcagccag ccggcttcct 90361 ctgccccttc ttggaggctc aggctcctgt cgccaacacc ccaggacctc ccagagaacg 90421 agctgctgca cccgcccttg aacatccgtg tggtggactg ccgggccttc ggtcgctaca 90481 cactggtggg ctcccatgcc gtcagctccc tgcgacgctt catctaccgg cccccagacc 90541 gctcggcccc cagctggaac accacgggta tggccacatc caccctgcca ccaagcctgg 90601 ctccacgccc cccagggaag ggctccaggt ctccgcccag tccaagccgc gaccagagtt 90661 tgctctttgg ggccgagggg gtgggcatag aagaaggtca ccctggtggc caaggaaggc 90721 tgcccaaggt gacgccagct ctacagccag agagggcaga actggagaca gcctgggggg 90781 gcctgagggc agaaagcccc ttgcgctggt tgatggagaa gacccaggcc tccccgccac 90841 ctccctccca ccggcctccg cagcttcccc ttatctcggg ctctcttctt ccctccccat 90901 gcccatattt tctcccttga ctgcctgtcc ccctctccct cagaaagttc cagaatcagc 90961 tttagttctc cgcaccttcc tgccccgcca atctcactgt tcctcttgct ccttcctctg 91021 cctgtctgtc catctatcca tctgtccagt caggcttctc cggcgctgcc gtgtgctgtg 91081 caatgggggc tcctcctctc actccacagg ggaggttgtg gtgactatgg agccagaggt 91141 acccatcaag aaactggaga ccatggtgaa gctggacgcg gtaaggcggg tggggtcagc 91201 cccctgctgg ctgggaacat gcaacttcgt gtgacacatc ctgtgaacca gactatctgc 91261 cccgagagaa aaggacacta agagcctcct ttggcatgtg actgtcgggg gctgagcttg 91321 attgtgtgtc caaacagctc cctcctaata ctatcctgga atgcacacgc gtgcgtgtgg 91381 tatgtaaatg tgcatgtgtg tgcgcatgtg tgtggtgtgc atatgtgcat gtgtgtgtgc 91441 atgcatgtga tgtatgtgca tttgtgcgtg catgcgtatg tgtggtgtgc atatgtgcat 91501 cgtgcatgta tgcatgtggt gtatgtgcat gtgtgtgtgc atgtatgtgg ggtatgtgca 91561 tatgcacgtg cgtgcgtgtg gtgtgcacat gtgcatgcat gtgtggtgta tgttcatatg 91621 cacgtgcatg catgcatgtg gtatgagcat gtgcatgtat gtgtgcatgc gtatggtgtg 91681 catatgtgca tgtggtgtgt gcatatgtgt gtgcatgtgg tgtgtaaatg catatgtgca 91741 tgtgtgcagt gtgcatgcat gcgggtggta ggtaaatgtg catgagtgtg gtatatatgc 91801 atatatgtgt gcatgtgcgc ttgtgtgcat atgtgcatgt gtgcatgtgg tatgtaaatg 91861 tgcatgtgtg catgtgtgca tgtggtgtat gtgcatatat gtgtgcatgc atgcttgcgg 91921 tgtgcttatg tgcacatgcg tgcatacatg tgggtgtgtg catgtgcact ggcatgtggt 91981 atgtgtgtat gagagacaga gtgagccatc acagtttatt ataatcacct gctataattt 92041 ttactccaac aaatgacacc ataggtaatg attccttatg agatcatcag tgtcctttcc 92101 aaagagtccc tggttttcca tcccagccat tcacaaatga cacttccctg gcctgggtca 92161 gaggaggatt tccaggtgga agctccttat tcctcctggc tttgggccta ggactgttca 92221 tctgccagag agagaactgc catctggggg ttgggtgtgg aagtggcgta caagctgtag 92281 accctacagg gaagggcaga acgtgggcca gcctggaaca cagcccactg ttcctttggc 92341 cacccaaaga aacatcctca ctcagaccct ttgcagactc accagtcaga gtgctcttat 92401 taatgcaaag ttggccttgc gggcacaggg gctgccagca cacagtaatt tccatctcgg 92461 ctcctccaca caccctgtgc taggccactg cctgccactc caggccccag tggctgattc 92521 tgcccctgtc tccttggttc ctctgcagac ttctgaagct gttgtcaagg tggatgtggt 92581 gagtgtgggg gccatgcagg ggctctgggg tgagagggtc ctttattggc aatgatgtca 92641 ggccaaaggg tccagcatca gggacagagc cagccccagc ccccgcatgc ttgggccagc 92701 acacctcccc taagatgcag tggaaaagag ctgggtgagt gcaggactcg gtgccagtcc 92761 tgcttgggcg agtggatcgc actggcaggt cacaacactc tgtggcctgt ggcaccttct 92821 ccataaaata aggccctgcc ccttggacat gggtggcccc acagagcctc atggagccca 92881 aggcttcctg ctgacagatg gcggaatggg tggaggctct cgggattgtc caggcaggag 92941 gagtccatgt aggactctgg acctggccaa cctgcaggct gaggaggaga aggagaagaa 93001 gaagaagaag aagggcactg cggaggagcc agaggaggag gagccagacg agagcatgct 93061 ggactggtgg tccaagtact ttgcctccat tgacaccatg aaggaggtga gacctcgggt 93121 agggtgaggg gaggtgaccc cctccacact cagaccctcc tgtccagctt ctttcccacg 93181 gcccccaaga gctggatccc aactccattc atgtgagttt gggatggttt tgtctcacat 93241 ccttgaaatc ctagctcaga actcaccttc caagatgatg gtcccatcta ccttccctgc 93301 ttggttttct tttgtcctca ttgactcatt ccacaaatgc ctcttgggta tatgcgatga 93361 gccaggctcc atactaggtg ctatgggagc caaaagatgc cacacctgcc ctgatgggcc 93421 tccggtttac tgggcaaaat ggacatgtaa acagagactt agagaggact atgtgataac 93481 aaaggcaaat catggcttgg gggaatcagg gaaggcgtct cagaggaggt gacctttgtg 93541 gaaaaggaga aacatgttct cagaggccat aagggaacaa ctgcttatca gtagtcctta 93601 cgactcttct tcataatgtt ttattttaca catcttggtc atcggcacgt gaatgattct 93661 tcccctatta cacatatgtg ggttccatct gtttggccag attgcaagtt ccagaaagcg 93721 catttctctg ctttcttgtt tgtgtcctct ccacgctgcc tacctagctc agggtgctct 93781 gactggccac ctgaccagga gggacacatg cctgcagttg tgtttcctca gtggggccag 93841 agctgatcca gccacatcct ctcccaggcc ctttctgtga cccaagctag gtgtgatatt 93901 tattagagca cacattaagc tgctgtagca agttagagtg aagtgaacaa gacagcagtt 93961 tatttctcac ataacatctc agagagtggg ggttaggctg gtatggtggc tcagtggtgt 94021 caaggactaa gatcctgacc tcttgtttgt cacatctgta aggttggagg tgactcaaca 94081 tcatgttcta attcaagtgc acaggaaggg ttaaagagga gatgaggcat atgcttttct 94141 ttttcagggc ccaatccaga agctgcacat atgacttcca ctcacattga tcagaatcta 94201 gtcccttagc tacacttatc tgcaaaggag gctgggaaat gtaatctttc acaaggtggc 94261 tgtgtgctca gcaaaacttg taaaaatagg agaacagatc attgaggaca actggtagtc 94321 tcgtctccca ccatcaagtt ggccaggctg gagctgcaag aggctgcctg ttgtcgtctc 94381 tactcctgca attttcacag actgccacca ggtggcggtg gcgacttagt tgaaacctgg 94441 tttctagttt ctagtaagat ttattctcgt ttccagtaag atggggtgtg ctgagtgaaa 94501 gaaaatatag tacattttct tactgttata cttttgtaca ttaaaacaat ttattaatat 94561 cactaaaagc aacattaaaa tgcactgtac ttttttaagt agaaaatgta aatatttatt 94621 gcaaggtgtt atttcttttt tttttaaatt atactttaag ttctagggta catgtgcaca 94681 atgtgcaggt ttgttacata tgtatgcatg tgccatgttg gtgtgctaca cccattaact 94741 cgtcatttac agtgggtatt gctcctaatg ctatccctcc cctctccccc agcaccacca 94801 caggccccgg tgtgtgatgt tcccctccct gtgtccaagt gttctcattg ttcagttccc 94861 tcccatgagt gagaacatgc agtgtttggt tttctgtcct tgtgacagtt tcttcagaat 94921 gatggtttct ggcttcatcc atgtccctgc aaaggacatg aactcatcct tttttatggc 94981 tgcatagtat tccatggtgt atatgtgcca cagatgcata aacccctaag taccactagt 95041 cacactgtac acattataaa ctttttttaa cccacttaag cagagcacat ggtggacttg 95101 aaatgcagta gggaagattt tctacttcta gtgcattaag actggtctgg gcccacaatt 95161 tggggtcaac agactcctcc ccaggaaacc caccttctgt ccttttcatc tcatcttttg 95221 gcagcaactt cgacaacaag agccctctgg aattgacttg gaggagaagg aggaagtgga 95281 caataccgag ggtgagccct ggaacctgga actctgcctc ctcctccccg cccctgggtg 95341 gtcagctctc ctgcccacct catcacctgc ttctcttttc cctcctgcca gccctcccag 95401 ccttagtagc cagggaagca gcatcagtaa tccatgggca gtactgggca ggctaaggcc 95461 cttgtccagg gaggctttta ctctgaccag ttcagcaccc acagtgatgg gcagacattt 95521 agagccacag aacatcagag ctagaaggga cctcagagct cattccatcc agcattttcc 95581 agactctttt ccatgaagaa aattgatgga tgttctagaa ggaacaaatt agttttggtc 95641 aaattagttt aggaaaagct gattgaaaca gcttgttttg gtgcaggact tttcataccc 95701 tttactgtgc aaatgttatt atacatctct aaaaggaaga cacagtataa aatatttccc 95761 cagcttattg gatcacagta ccctttcttc taaagcatgc cagcagcatc tgcaccaggt 95821 gctccactga atgaggtttg ggaaatgcta atacagagtg ttattattat ggacaagaag 95881 agggaagcta gtgaggaaag tgagtgggca aggaactgcg cagcaacagg cctccacccc 95941 caaacccatg ctccttcctg cccctctctt ccaaagggca tgaagacagt cttcagacac 96001 cttcccgggc ataaacccac tggggccccc agcacctcca tgaggcgggc atgctaggga 96061 gtattatctg catttgacag cacatggaca tccgagagtt aagttagtaa agcaaattag 96121 cgacagagct gggtctcgaa tccaggcctt cctgctctgc tcatttctgc tccacctcct 96181 tttctgcttc tggccaggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc 96241 caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc 96301 cgagaagaag aaacccaaga ttgatgagct taaggtgaga gcctaggagc agacccttct 96361 agggtgtgtg ggggcgggaa gaggggggcg cagtgatcct gcaggtgggg caggacaaaa 96421 gccagagacc aggcagccgc cccctaacag cctggtctgt ctcaggtata ccccaaagag 96481 ctggagtccg agtttgataa ctttgaggac tggctgcaca ctttcaactt gcttcggggc 96541 aagaccgggg atgatgagga tggctccacc gaggaggagc gcattgtggg acgcttcaag 96601 gtcaggccag gagcacgggc ccagcctgag cacccgccag cccttgcccc ccccacaggt 96661 tcccccactc acctcccacc actgccccgg ccactgcctc cagaagccct ggactctccc 96721 atgactcagc agttaaaggg tgaaggccct gccacatcag ggtccagccc tcctggtgct 96781 gttagctatt ttgaatgcca cccttgccag gcaaacctac accctgaccc acatttgtct 96841 tgcccagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt cccgggaagc 96901 cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc ccatcaatgt 96961 gctggtccga gtctatgtgg tccgggtgag actcccgtcg ctttccctcc ttgcaagtct 97021 cctcatcctc ccatctggga gagagcaaag aagctgcata ctggccaggt gcaatggttt 97081 acgcctgtaa tcccagcact ttgggaggcc aaggcaggag gatcacctga ggtcaggagt 97141 tcgagaccag cctggccaac atggttaaac cccgtctcta ctaaaaatac aaaaattagc 97201 caggcacagt gccacgcacc tgtaatccca gctactgagg aggctgaggc aggaaaatcg 97261 cttgaacctg ggaggtggag cttgcagtga gctgagatca cgtcattgca ctccagcctg 97321 ggagacagag cgagactctg tctcaaagga aaaaaaaaag aagaagaagc tgcatactga 97381 cagccccaga ctgggaggca ccagggagat catttggtct agtctttatc ttttctagag 97441 gaagaagtca acgcccagag aggggtagcc acttgcctag ggtcacacag caagcctcct 97501 gaggggtcca gtgctcctgc ccctgccctt cactgtcata ggaccctcag gcagcctggc 97561 aggggcactg aagatgagca gggcatggga gcctgctcag gcagcccttc tccccattcc 97621 aggccacgga cctgcaccct gctgacatca acggcaaagc tgacccctac atcgccatcc 97681 ggctaggcaa gactgacatc cgcgacaagg agaactacat ctccaagcag ctcaaccctg 97741 tctttgggaa gtaaggcttc ttggtgccct cccctgccac acccctactt ctccaaccca 97801 gaacacctcc caccctagcc aatccttaag cccttctcct aactccaccc caccaggtcc 97861 tttgacatcg aggcctcctt ccccatggaa tccatgctga cggtggctgt gtatgactgg 97921 gacctggtgg gcactgatga cctcattggg gaaaccaaga tcgacctgga gaaccgcttc 97981 tacagcaagc accgcgccac ctgcggcatc gcccagacct actccacgta tgtggggcat 98041 ggggcagagg gcgggggcag tgtgcctgct ttgcctccac tctaaaatga gattcagatc 98101 ctggtgattt gagaggttag acattgtggt ttctgtccca ggccaggcct ctgcccctac 98161 agtccctggg cacagtcttc aggggacagg actgcagatc ccaaaacaag gagagggaca 98221 gtggattcca ggacagagga ggcaggacga ggagagacaa gtgggctagg gaaggtgggg 98281 gctagcaaga ggaggacaga aagagtcccc tggggatctg ggccagctct gccacttata 98341 ggctgtgtga ccctggccaa gtcccttcac ctctctggtt ttcagtttcc tcatgggagt 98401 ctctgaggtt ccagaggagt gggcacagtg aggggatgca gtggggctag gctggggaca 98461 ctgatatgtg gtccaaggcc cagggcagga aggttcagcc tccagcagcc ctagtgtctc 98521 aggtgagcct ggggcccagg gcaggaggaa tcaggctcac ttgctgatga gggcaacagc 98581 caactttaga gaactggcca cgaccagctg tcatccagga tggcttagtc ccacccagcc 98641 cctccaagcc tgtgtgtccc ctcccacaga catggctaca atatctggcg ggaccccatg 98701 aagcccagcc agatcctgac ccgcctctgc aaagacggca aagtggacgg cccccacttt 98761 gggccccctg ggagagtgaa ggtggccaac cgcgtcttca ctgggccctc tgagattgag 98821 gacgagaacg gtaatggggc actggatgca gccgcctgcc ccctctccag ggggtttcag 98881 aggccaggag gggcccacac ttccctgggg aacctcacag cctagcctgg ggtgtcctca 98941 gcctaaacct ggtcttagtg accctctgct catcacccca gagccccgtt cctgtctgcc 99001 cagcctctgt gcttccaccc ctcctacagg gcagccccac ctgctttctc tctgtccaaa 99061 tcccagtgag gtagagaggc tatctgcatc ccattctgca gataaacaaa ccaagatcct 99121 acttctagtg actcgcccaa ggtcatgtgg ctctttagag gcagagcgag ggcatcggcc 99181 caggtccatc tggctctaat ccttaaactc tccttacttc tctgtccatg aggcacttcc 99241 cagagaagca gagaattggg aggtgtctgt gctggtatct gatcactttc aggtgctggg 99301 acaggaagtg gattctcccc tccctgaccc ttctctcagc ccagcagggc tctccagtca 99361 acttccccaa gcagaggacc aagggcacag acctctcttg gccctgtggg gcagctgaga 99421 ccctgggcaa gccacttctc cttctgtgcc tcagtttccc caacagtgaa aaggaggtgg 99481 ggtagacagg tgatggcata gaggcttctt tgtgctccta agtccctagt cccagcaaag 99541 gtcttctggt tctgctgagc catgtgtgca gctgagccgc cggcacccac aggtcagagg 99601 aagcccacag acgagcatgt ggcgctgttg gccctgaggc actgggagga catcccccgc 99661 gcaggctgcc gcctggtgcc agagcatgtg gagacgaggc cgctgctcaa ccccgacaag 99721 ccgggcatcg agcaggtgac acttgcatgg ccaagactgg ggttcttggg tattggggac 99781 cagggatccc caacctgagt cagtaaaggt agaagccagg cctcacgctg tccgctgcat 99841 tccagaaagc ctggcaggca ccttcccacc aaggcccctc agggtaactt gaatggcaag 99901 ggtctttgct ttgagtgaga attacatcag ctcaggcaga gacctgggtt gtctccctca 99961 gaagctgtga ttggctattg gtgacatcat aggaattcct ggcatccaaa gatggaaact 100021 gatgaactgg gtccttgaca gaacaaaggt taggagggag aggagagctg atcttcctgg 100081 gcagagggag aaggccctgg gagatctgcc acaaccctct tcctcagggc cgcctggagc 100141 tgtgggtgga catgttcccc atggacatgc cagcccctgg gacgcctctg gacatctcac 100201 ctcggaagcc caagaagtga gcggcctggg gcccagcgct actcccttcc ggcccacccc 100261 acccacttcc caccacggcc caacccttcc tgcggggggc tcaggtccag atggccttgg 100321 ccagttggca tccctggggc ctgggtgtgg ccactgggcc ttatagggga gaaactgacc 100381 aaccaatcga tagagtttag ggcctgccct ggagagtccc cacgtgctaa ggcaggacaa 100441 cgccttccac cctgcatcag tgagcgagac aagccccaca cagcacactc cggtgcattg 100501 tatctacacg gtctacgcgc ccatacacat gcatctcatg cacacacaca cacacagcat 100561 agcactccca cggacaccca cacacatgcc cacactgacg cactccttca caacacacag 100621 aacccctggg agccggccct gcgtcatcct cacatccagg ctagtgtgat gttccgccaa 100681 gttttctttg gagtgcctgc cagtgatgaa tccaggagtg agtgcctgga agaggcagga 100741 ggtggtagag tgaaaagaac ccgggtttcc catccataaa gcggcaggtt caagtccagc 100801 tgtcagacag tgactggatt cagggccagc ttcagggatg gaggaagcca cacagggtcc 100861 cactcttgtt tccatgctcc tatgttgcca tcttgaaatt ctttatgaca agtgaccctg 100921 catttccatt tggcgctggc cccagcaaat catgcagcaa attctgccag gaatgtcctg 100981 gaaacctgag gccatgagtc agctgttcca gggcctgtca ttagggggca cccaactcac 101041 tgggccactc tgggctcgca gccctgtctg caatcccagg agagccatgc tcagatcaat 101101 ttttagtgaa tgactcagcc tcactcttaa tgattgaaat gaactacatc attcataatt 101161 acaattaaac cttgagggga aaatcctctt tggggacagg gacatacagc ttccatgggc 101221 ttccattgct ggctactggg cttaaatgca gacttctctt ggaactagca tctgagacag 101281 agggtggctt cctcccctca ccccaccccc accgcccaca gccatgtgcc tggtgggcct 101341 tctcactcat gcctctgctc ccccaacccc aaaccactcc tccagcccca gcctggccca 101401 ggccctgtgc tgaccccaag accccagggc ttctctccgc ctgccccatc ccagccctgg 101461 caccctggca taacccccac ctggggctgc taaccagcct tctctccctg ggcccaggta 101521 cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg acgacttctt 101581 cacaggggag aagtccagtg acatcttcgt gagggggtgg gtgagcagtc cctgcatggg 101641 agggactgag ctgggtgggg cttgcttccc ggggggcagg agaggaggca gagggaaggt 101701 ggctgtgggt gggagaggcc ccaccagcct ggctgcgggt ctggagatgt ggcgcccaca 101761 ggtggctgaa gggccagcag gaggacaagc aggacacaga cgtccactac cactccctca 101821 ctggcgaggg caacttcaac tggcgctacc tgttcccctt cgactacctg gcggcggagg 101881 agaagatcgt catctccaag aaggagtcca tgttctcctg ggacgagacc gagtacaaga 101941 tccccgcgcg gctcaccctg cagatctggg atgcggacca cttctccgct gacgacttcc 102001 tgggtgcaga gcagggcagg gatgggggtt caggatccag aactgagaag aggcaggggc 102061 cgggttggcg gggacaggga gagccctgcc ttggggggac aaggggtcat tgcttccagt 102121 ccatcagagc caggggtgtc cgacggggtt ccgcccccaa ggacccacct aaccgtccct 102181 aggcagatgt tctcagtgtc ataaccaggc tgacaacaag ctttggacac accaaggagg 102241 gggcagtcag tgatgatggg ggaggggaga ggctccctaa gggagtcggg aaacctccct 102301 gggcctcagg ttgcttctct gtaaagcagg gattctccct aaaactctaa tctgcatctg 102361 caaaagcttg tgggattagc aggactttga cagaatggat gcatggcagg gagtggcagg 102421 ggagacccca ggagagaccc tctggggtga aagaaggacc tgagtaaagc atgggggctg 102481 gggctgccta gcaagcccac gaggatgcct gcattgaggc cagttgctgg gagtgaggca 102541 ggaggatgag atgtgggctc agggaggtct gcactcagca aacaaggggc cgaggagccc 102601 agacccccac ccccaccccg ccccacccca gccctgttca ctctgagctg acactgaggt 102661 tgccacaggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaa agacagccaa 102721 gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa 102781 gcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga 102841 gctcacggtg cgcacccctt cctgctcggg cagtaggcag ggctgggact ggctggggtg 102901 ccaagggccc agcacgcagc ctggacgctg ggacctgtct gtcctctgca gggcaaggtg 102961 gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagt gggcctggcc 103021 cgcaatgaac ctgaccccct agagaaaccc aagtgagtgc cctgccggcc cagcccctcc 103081 ccactctggc tcttggaggc gctggaacag gaaggagacg atccccagac accccatctc 103141 ttcctgggcc acagcctcat tacaggggag cctcctccct gccctctgcc aaccctgaat 103201 cccacaacgt ccctttgaac cagaggatgg gctaggaata ctggagagca ggaccttccc 103261 tgggaaaggc cccatctagc ggagagaaac tatgctcttc ccttcctagc ttttgcagaa 103321 gagccagctc cagtggtggc ctctggggcc atggccagcc ttgatggcca gaggggtgcc 103381 tagaactgca cacacagccc aggacagctt ccctcttggt cttggcccct cgccacaccc 103441 aatcccttct cctccctgtc cctcctctgc gctctctacc cttcatactc cagccggccc 103501 gacacgagct tcatctggtt cctgaaccct ctcaagtcgg ctcgctactt cttgtggcac 103561 acgtatcgct ggctgctcct caaactgttg ctgctcctgc tgctgctcct cctcctcgcc 103621 ctgttcctct actctgtgcc tggctacctg gtcaagaaaa tcctcggggc ctgagcccag 103681 tggcctcctg ggtctgatat ttcttacttc ttcctctgga ccaagggcta ggcaggcgcg 103741 tgcacacaca cacatataca cgcacacatc cacaaacaca aatatgcata catgtgcaca 103801 caaacacaca caagcatgta tgcacacatg tgccacgcac aagtgcatac acatgcactc 103861 aagcacacac aggcacacac ttaagcccac acaaacatgc acagcaactt tcaagctttc 103921 atgacagaat agactctcag aactagaaat gactatttta cacttttcca cattaagcca 103981 aagaggtgaa gtagcttgct caaggttacc cagcaaatta gggtagagcc gggactcaag 104041 ccaaggtttc caaatttcca atcctgtgtt ctttgcacac cacctctgct cccagccatg 104101 tttctcccag actgtaaccc aatttttttt tttttttttt ttttttggag acagagtctc 104161 gctctgtcgc ccaggctaga gtgcagtggc acaatcttgg ctcactgcca gctccgcctc 104221 ccgggttcac gccattctcc tgcctcagcc tcctgagtag ctgggactac aggcacccgc 104281 caccacgcct ggataatttt ttgtattttt agtagagacg gggtttcact gtgttagcca 104341 ggatggtctc gatctcctga cctcgtgatc cgcccatctc ggcctcccaa agtgctggga 104401 ttacaggcgt gagccaccgc gcccagccga ctctaaccca atttcattgg cagaaagaag 104461 ctgagctatg gacagggaaa agggaagggt gtggccaggg ttagccaaca ggtctggaaa 104521 tggctctcac ccgtgtgtga cctcccagtc cagggctgtt gttttctgcc cttcaggata 104581 ataattccat tcaactcaaa catttcatag ccaccatggc ctgaacaccc aactgcaggt 104641 gctcagagct ccccaggcac tggctcactg tgccattgcg ccaaacccag gaggtaggta 104701 ctgcttgtaa ccccatttta tacatgaaga aaccgaggtt gatagaggtg cctcacttgc 104761 ctgtgaaaac cattcaaaac caggtgccct gcacccaagc cccggctctg tgtccccacc 104821 aatactgagc tcagctctgg ggctgcacgc catgtcctct gggaggcagt agtttgaaaa 104881 tgcatatgca gtactttcac ttgtatcttg acattttaca aaacctattg tttttataac 104941 acaaacgaca gatagtgagg ctggccaggt gcttctcggc tgggaggctc tacagaaggt 105001 ggagtgggtc ttcatcctga gagtgggcag gtcggtgagg gcagcttgca ccccacaggg 105061 gctgctcaga ccctcagcag ggcccggtgg gaacagccat ttatgtccat cagaaaggaa 105121 gaggttgtga agcaccagtc ttaccaagga cgtggggcag cacatagaac gagctaaccg 105181 caggagcttc ctaacgatga gaactgcctg cagggccaag gctgccccat gctgcaagta 105241 gctcccatct aggccttagg aggagattcg ggccccaaag gtgctgcagg gaggatagag 105301 ttttgtaagc agcaagtcgg gtacttagaa atgggtttaa accctggctc cagcattcac 105361 tgcttttggg gctggggcca tggcagggct tttgggggtc cagaaggaca gaggatgggg 105421 tgcactggga ggcagctcct gcccactggc tgaccggctc ctctcttcca cttcccagcc 105481 ggcccgacac ggccttcgtc tggttcctca accctctcaa gtccatcaag tacctcatct 105541 gcacccggta caagtggctc atcatcaaga tcgtgctggc gctgttgggg ctgctcatgt 105601 tggggctctt cctctacagc ctccctggct acatggtcaa aaagctcctt ggggcatgaa 105661 ggccgccagc tcccgccagc cgctccccag ccctgccgca tttcctttca gtggcttgga 105721 ctctttccca tctcccctgg ggagcctgag gagcccagcg tccactcttc atgccttggg 105781 ccgagcctgc ctcctgcttg cgggggccgc ctgtcctcac tgccccaggc tgcggcttgc 105841 ccagtcccgc ccctctgacc cctgcctgtg ggctggggag ccttggatgg ggtggggacc 105901 tggaatgggt ctctcttgcc ccacctggct gaggcgccac ccttcttcag gcccaggctc 105961 cagaggaaga ctcctgaaac cctccccagg tcttccaagt acaggattga agctttagtg 106021 aaattaacca aggaccatgg gtcagtgccc agggctttaa aaagaatgaa cgagcaaaag 106081 gtatccccgc cgtgacccct gcagatagca ccggtctttg atccgcagca ggggccagac 106141 cctgcccaca agtcccagcg cggctgcttc tgccactgct gggctccact tggctcctct 106201 cacttcccag ggggtcgcct gtcctgcctg tgggtttcca tggcttccca gagctccctc 106261 tgccccagcc agcgcctcca ggcccagctg aggagctgtg agaagcagca gaggggactc 106321 cccatcccgg gcacaccctg tcctcccacc cctgccccct tgcccttcca gccctttcag 106381 ctgcagctgg gagctggccc gtcaagtgct gcccctgcct gtgtctgggt ttctgttggc 106441 tgtttttctt ttcttgagtg gtgatttttc tctaaataaa agaagtcaag cactgagctg 106501 acaggtctgc actggtcaag ctgagaggag cagccgcagg tgcggggcag aggcagcagt 106561 tctctaggct ggcagattca gtaccagcag ggctcccatg gcctttcccc ttcaagtggc 106621 ctctggtggc ccagggttca aggcaggcct caggcacagg gctgcccacc caggctgccc 106681 acaggaggag tcttacacca tagcccaaag ggcacaccag cctgggccca ggggccccca 106741 aagcaccgaa agaatccttc aggtctgggg ccagtctgaa ggcttaaggc cccacaaggg 106801 cccaaaagct ctagcctcca cccacagaaa ccagttcccc tgaaagcaag aaaggagccc 106861 cacgctactg gcctcggcct ctgactcaca ccactatctg agcctggggc aaagtcccct 106921 catgacacag aggtaggggc aagggcctgg tcttgctaga cctgacctct ttaaagagat 106981 tcagccacaa ctttaaaagg ctttaatcat aatgcaggac acaggtaact cctctggctc 107041 cttatttcga caggctataa agacagccct ggaaaatcca gagagcaggc ccaggtgcgg 107101 cccagtgggt gatatgagct ggctccggca cagacaccag catcaggcca gccctaacac 107161 atcagccttt ggcggtccag ctcattttgt gggtacccgc aacacctgag tgggaggaac 107221 ttgcagttca gagttgatct ggaaaagaaa gggtgaaagt cgttacattt ttcccagggc 107281 cctccttctt tgccaccctt gcgagccacg ctggctctcc catgggcctc caaagccctg 107341 cacgcatctc ctctccaaag ctgagagatg ctgaacaccc acagactgcc tccctgcagg 107401 agacacgcct gagccttctt gctcagcttc tgctccagct gtgacctctg gtagcgttct 107461 tcatctcccg cccgtccatt ctctgcagtc ttcccctctc ctctctccac gcacccatgc 107521 catccccaat ctagcctgcc ccacctcttc ctcccccagc ctcttgtata cagtagcatc 107581 tgtggaagcg ggaaccatac cgtccagaat gtctgggtcc tgtcacaggc caagggtcat 107641 tatgaggcca aggttcacta caacatccca ctttcagctg tggcctggga cctgggactg 107701 tgctggggcc acgcagcccc tgtggctgga cttggagctg gcctcagtca cctcacacgt 107761 gtgcaactaa cagctgcgtc acgaccttcc tggcctacag ccccagctgc aggtgcccac 107821 acccgcagag caggaaatgt cagcaatgga ctttttcctt cctcctcttg ccaggccatg 107881 gggaagttgt ccacaactat tgcagggttg ggcacagatg ggggccaggg aatatctgcc 107941 ccagcagagc ctccttcccc atgcgaggat gaccctccag tcatatccca ggcagggaac 108001 cggggctggt gggtggaaag agcccaggct ctggacgagt tgcaaactct gcaagttgtg 108061 attgtccttt gtgtgaaatg aggagcattg tttccgccct gtccacctca cacagcgggt 108121 gtgaggatgg aagaagagag cacagctgga ggctctgtag ctggggagct gctcctggct 108181 gtggcactgc ttcacacaga gcagtcccag ctggccactg gcaccagaaa ccacagtatc 108241 aaagagacac tgtcacacct gagctgtcct ggaggagact tcaggcaaga tctactcctt 108301 tggccagtag ttgtctcaag gtgccactct tgatttttta catcatatca caaagctccc 108361 ttgcctctga cggggagggg actcctcgtt ccctaatccc agctccagtg cccctgcccc 108421 acccgtgtct cccgctgccc ctccttggaa ggccccgccg cccaccttgg agttcagata 108481 ctgctgcagt agcgcc

Norrin Cystine Knot Growth Factor (NDP)

[0132] The NDP gene encodes “norrin cystine knot growth factor” (NDP). The human ND gene is located on chromosome Xp11.3. It contains 3 exons, encompassing kilobases (kb) (NCBI Accession No. NG_009832.1). NDP encodes secreted norrin protein that plays a role in retina vascularization of Wnt signaling pathway through (FZDA) and (LRP5) coreceptor. Mutations in NDP have been associated with Norrie Disease Pseudoglioma, an X-linked recessive syndromic hearing loss that is characterized by early childhood retinopathy. About one third of individuals with Norrie disease develop progressive hearing loss, and more than half experience developmental delays in motor skills.

[0133] Various mutations in the NDP gene have been associated with hearing loss (e.g., Norrie Disease Pseudoglioma). For example, the p.His4ArgfsX21, p.Asp23GlufsX9, p.Arg38Cys, p.Ile48ValfsX55, p.His50Asp, p.Ser57*, p.Cys93Arg, p.Lys104Gln, p.Gly113Asp, p.Arg121G1n, and p.Cys126Arg mutation have each been associated with Norrie disease pseudoglioma. See, e.g., Musada et al., Mol. Vis. 22:491-502, 2016; Chamney et al., Eye (Lond) 25(12):1658, 2011; Liu et al., J Chin. Med. Assoc. 79(11):633-638, 2016; and Parzefall et al., Audiol. Neurootol. 19(3):203-209, 2014.

[0134] Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

[0135] An exemplary human wildtype NDP protein is or includes the sequence of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 25, SEQ ID NO: 26, or SEQ ID NO: 27. Non-limiting examples of nucleic acid encoding a wildtype NDP protein are or include SEQ ID NO: 21, SEQ ID NO: 22 or SEQ ID NO: 24. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 21, SEQ ID NO: 22 or SEQ ID NO: 24 can be codon-optimized to allow for optimal expression in a non-human mammal.

TABLE-US-00007 Human Mature NDP Protein (NCBI Accession No. NP_000257.1) (SEQ ID NO: 20) MKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCH CCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS Human Mature NDP cDNA (SEQ ID NO: 21) atgaaaacggacagctcattcataatggactcggaccctcgacgctgcatgaggcaccactatgtggattc tatcagtcacccattgtacaagtgtagctcaaagatggtgctcctggccaggtgcgaggggcactgcagcc aggcgtcacgctccgagcctttggtgtcgttcagcactgtcctcaagcaacccttccgttcctcctgtcac tgctgccggccccagacttccaagctgaaggcactgcggctgcgatgctcagggggcatgcgactcactgc cacctaccggtacatcctctcctgtcactgcgaggaatgcaattcc

[0136] A non-limiting example of a human wildtype NDP genomic DNA sequence is SEQ ID NO: 22. The exons in SEQ ID NO: 22 are: nucleotide positions 1-87 (exon 1); nucleotide positions 88-468 (exon 2) and nucleotide positions 469-1719 (exon 3).

TABLE-US-00008 Human NDP Gene Sequence (NCBI Reference Sequence: NG_009832.1) (SEQ ID NO: 22)     1 aagatgctcc gtggaaggga gccgagcggt gggcagaggc tgagtccccg ataacgagcg    61 cctcacattt ccgtggcatt cccatttgct agtgcgctgc tgcggccgca cgcctgattg   121 atatatgact gcaatggcac ttttccattt gacattctct ctctctctct ccctctctct   181 ctctccctct ctctctccct ctctctctct ccctgtgtcg cttaaacaac agtcctaact   241 tttgtgtgtt gcaaatataa aaggcaagcc atgtgacaga gggacagaag aacaaaagca   301 tttggaagta acaggacctc tttctagctc tcagaaaagt ctgagaagaa aggagccctg   361 cgttccccta aggtaagcag gaaaacaagc gctgccggct tgcctaggaa atcgcttctt   421 tccaaaccga gcatttcatc ctcctctcag acaaagagac aacctttaaa taccacttaa   481 atttgcatta ctttaatttg cattaatctg tagcatgcta gcattgtgtt tcttaaatga   541 acgggtcttt gaagtctgtg acagagcagg gagcctccta gaaaagcttg aaaatatctt   601 ttggtttgac ttaaagagat ttttcttttc aaactctctg cgtagttaga tgtaactttg   661 tgatggttct tatagttgac cccgtgaaag ggggctgcga agcagcaact tgccaacatg   721 gattcatgga gcccagtatc ttccccagca ccctcatccc acttacaatg ggggcactat   781 taacgcaggc aagactgcga gtttaaaagc gcactgttta cttttattac tacttatgta   841 tgctgctgat ctcctgccag ggctctgccg gagtgctcag aatgacttca aacaataggc   901 aacatttatt tctagctttc tgtgtcacgc tttgcaggaa tcctgctccc ttgcactctt   961 ctttcagcgt gcaggtcttc gcttccatag atgcattggg gagcaccggg aggagatgag  1021 gatggattta ctgtatgatt ttgattgggc aaaaagtccg aggaaatgca tgctgtttgc  1081 cttggactta ttgcaggggg ttatttttag tcatcagctc gtccctgcag catgatgttc  1141 aaggagtgac cgggaaagga tgctcccacc agcacagaga ccaggacctg taggaatgac  1201 tcctacctgc gggatattcc gaggtttctt tcaaactttg gaatacaagt tctctcttta  1261 aatgaacaat tgagctgtag gaggcctggg cataactctt tcttggggga cgggaagttt  1321 gattgtgtac agaatgttaa tgactcagaa cgcccagtaa ctgaggctca ttgtaataga  1381 caaacccaga taagcctcca tgagaggcag actcccatct ttactgagat tcaggtgcgg  1441 gaaaggaagc tatttggcaa gatgggagtc ccttgtacag ttctttgtaa ctcattaata  1501 acagatatgg ctgctgtgaa acatgtctct tttcatttct aatattagtg tattttaatt  1561 acaaggagct ggcattggca aattacccca acacataaga ttaaatacca ggtgcatttg  1621 aaaacagaga gatgactgaa atggggagtt gctgtgggtg tcaaccaaat acagcgggga  1681 cggcacaatg cttctcaact gagcgtttaa accagatgca aatatctgct cattttcttc  1741 tcatcagtct tactaattca aggaaacttt atggtcctgt ttgccagttt tcattgcaaa  1801 ttggtacaca gtttatgcaa aacttttctg attttctctg ataaccagcc caataagcat  1861 cgctgaatga aaatctgata tttgaatagg ttaatttaca actttggggt attcattagt  1921 caagaaagcc ataaaagaca ctatggattc cattgctgta aaattttatt gtaatttttt  1981 tttaaaaaaa ctgcggttag caaagcattt agctgaatca aaacaatttt cttagactat  2041 tattcagatc attacatgag agtatttgaa cacaaaatgc aatgttttgc atcatttatt  2101 ttaaaataca tttggttcag gtaacgggag aactggctga ggccttctta cgactgtgta  2161 ccaagcagct gacacccaca gatggaaatg tgcctgtgga gttttcaatc ttaattcgag  2221 ttccaatgac actgtcaagg gaaaaataaa tcatttttca atacatttaa caatttccaa  2281 ctcatttatt ttcctgggcc cttgaaaaat gtggtgagtt tcttggaatt atagccacca  2341 atggtggcca gcaatcttta ttttaagaac tcacaattca agtactatta ttctctggtt  2401 aattatttat ttcatcaatt tttaaataaa tatttattaa gcattttcta gatgcccagt  2461 gctatgctag tcccgatgga tgcaaaggtg aatgagacat tgtcccatac tctaattctc  2521 agtccatatg ccatctctag ttagattttg gaactgaaat gggcattgcc aatgggtaaa  2581 gtgggcaata actttcctgt tataaagaat tatttaaaac agctactggt ttctagattt  2641 acttgaaatg attctcactc atcagtgggt tttctttcca tttatgatta agggattccc  2701 ctttggcctt tttcaccaga tcctgggtac acgtcatttg cacagctaac acggctagat  2761 ctttccagcc tgggtagaag aatcccggaa aaagacagta gtttatcctt tctctgctct  2821 cctgagcacc ctgtggaaag gaccatatgc tgtctctatt ggggatgggt gtgagtcgcc  2881 tactcagtag ctaacatcag ggccacttga tgaatcatcg aattagaaac atgcatatgg  2941 aggaagatgc agtcactatc cctcaccact tacttgtccc acccccagta tcaaaacaaa  3001 tgacctctgg gcctggccta aattcaagag gcccctggga agaagctgtt ggaaactctt  3061 ccccaaaccc aggtctccat catagccaca cagtgttgct ttcaaataac ccagtatggt  3121 gttttatcac gtgtttaggt tactggggga aaaaaaaaac cctgaaaaca gcatcaccag  3181 ggtccttgac ttggtcctta tcagcagata atcccccgtg gttggattaa aatgcctctg  3241 actccctggg gtgcctgact caccctagcc agccctcagc ttcttggcca gcggccttcg  3301 agcccatcct cacctcttcc catgacggcc agtgactgct tctttgccca ggccctctgc  3361 actaggccag cagccagtgg gagcagaggg gatgggaagg caggtggaca gactgtgaag  3421 tgctaaggca gagcggggaa gcagggctgt gagacagggt gggtgagctc cagggcctgg  3481 gttgctgtgg cctgccctgg ctgtgatcag ctgtcatttc ctctttgtgt atgacactgt  3541 ggaacatatt aaaatttctc tgggatggta tgtttggaat tcctctgatg ccccacctca  3601 ccaacttacc cggacaataa aagcaaggtt gtaagccttt gaacagctgg ctggctatat  3661 atttcccttc tttctttcgc ataatctaat tcagaaaaga atccagctag actggcagtg  3721 ccatgtctgg gtacttgttt cctgcaagtc cttcctcctc cacctcctcc cgccagtcct  3781 ggaatcttcc tgggtggcat gtggcttttc ttttcttttg ctcaccactg ctcccagccc  3841 gccccctttt cccttcgcct gagctccttc ctttgtcagc tggctctttg ctctgcctgt  3901 tttccagaca gcttgggtcc tgttccatcc ggggagaaca gcccatggga tctccccatc  3961 tccatagtat tcccaggatg tcattcttgg caccagctct gccgggctga taggactggg  4021 gggctttttg tagtcccgag cctgaatcca ctcacagaga ggagcagcca catggcttag  4081 ctgccctttg ggctgccgag agcggggctg gagtgaccgg gttggcagga acgagcatac  4141 catcacagtg acccgaacat ctccggcaaa ggccttgggg tgggagcgct atgggaatgc  4201 ctggatgcac ttcggcctac attaagagaa atgtggttat tctctgtttc gggggagaga  4261 caagcggctt gaaacaaagc cctctggatc cttggcccct tccctgcccc ctttcccggt  4321 ctgtccttcc cacatccctc cctccccaaa cagaaagaaa gagagacagg acttctaatt  4381 tggccagcac agacccgaat gtctttatga aacccattta gtgaaagaaa gaggggagaa  4441 atatattctg ggttgatccg aactaaaaaa tgcatggggc tttggagatg gggcgggatt  4501 ttttctttct ttctttctgt ctcttaagag cagaacaaca gtttcgttga tgagttgcaa  4561 atggaaggaa gtggacctct caattagaga ttcccattta agagcctcaa tgtaaacctc  4621 cctgtgacat ccttaaaaga tgctgctaat gtccctggga ccaaaaggta ttaaacagca  4681 agccaccagg cggcttccta ttccttttct ttttctgggg gctttggtcg tctttttcaa  4741 attagctaaa attcattaaa ggacccaaaa ggaaaaattt aaagcagctg aattaaaatg  4801 agtctttccc tgttagcctg acaagaagaa aaaaagaaag gaagaaaggg aaagaaagag  4861 aagaaagaac caattcccct ccactaccac ttcttgggtt ttaatatgaa ttattccata  4921 caagtcccta ggctagagga tctatttaaa gacgcctggc agcatgaagg gagagggtaa  4981 aaatacaacc actcttttgt ccatcaaagg ttttctttgg gaggacatta agagcattcc  5041 tgttttcttg tctgcccctg ccagtggcaa tgttccagct ggtagtatcc actcctcgcc  5101 catcaggtca gcaatcatga acttctgtgt ttaatttcag gagaaaacaa agggtgggaa  5161 atccttccga aacccctatg tgtgtgcagc agggcagggg aggctggaac tggaatcagt  5221 actctcttgg ctgtgcaggt tgcatgctgc aaattcacac acccacacag ttgagttgtt  5281 gaggaagatt gtgccgatgg cattatttct gatgccagct tcccttgcat ctgcaaagct  5341 tttttcttgt gtctctggca gtcatttgct tgtcaccatt catgtgcact gtccccttca  5401 tcagaggttc tcagagcctg atggtcaagg atatgtcact agagtcttac ccccagaccc  5461 attttcaaca gtaagaacgt gaaaccctgg atggggtttg caatctgaag caactacttt  5521 cttgttagga agagtgctga ctcagaaaat tcaaagaatg ggtaacttcc gttggcgaca  5581 tatccccagt gctcataatc aggaattcat ccagttgggg tccatttcac cctcatggca  5641 aaatctggac ataaacattg actagtagct ttaaactggg tataagattt gcaacagata  5701 acatttttgt cttttctttt ttcttttttt tttccacaaa agctaagaat ttttcagaca  5761 atttgctctc ttccaaggcc tggatcaatc ccaacttttt cttttaagcc atgatccaac  5821 caattgcagt atcctttaaa aatgaaaggg caacaggcta agacattcaa gaaagttgat  5881 aagcbgtcag aaaatgctca agggtggcct ttctacagtg ccacaaacca acaacagccc  5941 taaacgtgga gtcctcttcc atcctttcat cagtagggaa taaaaatagg gagagagcag  6001 gtcaggggag aagtaacaaa agagaagtaa gaaggattat ttttgatgtt caaaatctgc  6061 tgctgccctt tcaatatttt caaatatcac aatttcagaa agggaaggat ccctttattt  6121 cacccactct ccctcccagg aaggtgtttg aagttgctgt ctttacctga aaaggaggtc  6181 aactcctcaa gtgaaaaaac atcccctatc ttcaactcga agtaaaatgg aggtacacac  6241 atttgtacct aattatgtgg gtacaaatat aatttgtatc cacaaactat aaaggatgta  6301 aagaatcaaa gaaatccaat ccttaatcaa agtccaattt ttctttaaaa cttgagagga  6361 tattttaggg ctcattgcat tgctgtgatt tcactgcccc ccaccaaatt atgaaaaatt  6421 actccttttc agaatttaaa tttttctttt gagatgtgga atccaaaggc agcagaatag  6481 tattgttaca gggaagctgg cagtcaaaag acatagacat agctgcagca tgcatggttt  6541 aagcaaatca agacaagcag aaaaccacca ccccaacaag ttcagggtta tcagcaatat  6601 agggacacgt atttttatgt gatttttatg agaaccttgc ccctttgaca tatgtctgag  6661 tctaggagca ttccggattg caacgggatt gaattcagta ttcaaatccc accattgggc  6721 agaaaaggca aattgaatgg ggaatggaaa gactgagttg ctcctattgt ttatgcccca  6781 ttcctaacta agggctctac agctgttagg tgagatcact acccaccatt ccaaagtgtt  6841 gttgcjggtg aggaggttca aacgcagctt tggaaacact ttgctgcact ctttgaagaa  6901 aggccaacat gctcatttgg ctctagggta aaagagagcc tgtaccctga gctaacattg  6961 gtcacctctc ctcctgaggc cataccacag ccagcagtac agcagcagaa caagtgttta  7021 gttgtttcag cacaggtatc cccagaacac ctggcacctt ttcttttcca cagggagaat  7081 gtacattcat gcattttggc aagactgagt cctctgagtt gggtgtctcg gaactctcct  7141 attttccttc taaagggtct tatgtaaggt gagcagtaga gbitgtctca ttcctcataa  7201 aaaatcccct tcctgggagg gagtgggtga aatgaaggga tccttccctg actgaaattg  7261 tgctatttga aaaaattgaa agggcagtgg cagattttga acttcaaaat gaatccttcc  7321 tcctcctcct cctcttttgt tacttctccc atgacctgct ctctccctac tttaattccc  7381 cattgaagaa aggatagaag aggactctgt gtttagggct actgttgatt tgtggcacta  7441 tagaaaggcc acccctaagc attttctgac agctcatccc catctcagtc acagctttta  7501 tttgggtagc tggatttaca gaaataatca aatccctaga ggaaaagact tcaacagaaa  7561 agtacctcct gacacttggg taacctgact tggtcatttc caatttatgc aagatttgta  7621 ttctaaaagt caattagtta tgtcaactgt taaaaactca gaatgagtct ttccattctt  7681 cagaatgact cttttctgat tatctgtggg ccatagaagc ccacagatac tcagcacagg  7741 atccaagtgc cataccaagt ggtcaactct tttagacgta agtctcagcc cagggcttct  7801 ggaatgtacc tcccctagca gagaagctct gtagtagata ctttaccaag cacagggcct  7861 cgctcttgac cccaagacta ctgattctac ttgcagagaa gacaactttt ctaatcaatc  7921 tttctcttct atcctgaacc agagtatcag agattgtccc attagggcac gaggatctgt  7981 ggctcaagct cagttaagaa ataagcgtct ttcaaaagaa aggtgcaaga gggtggaact  8041 cagcctatat tgtcattatc aaatgcaaga agtctaatcc tagcatgatt tattaatatt  8101 agcctttctt ctctccccgt ttatgctttg gtgggtactg gacagaaacc ccacaaattt  8161 taagacagtt ttaagagaaa tagtaactgg ttaaatatcc tcactacttc aaattattat  8221 tattattatt gatattactg ttaacttttg tttttttgag acagggtctc actctgatgc  8281 ccaggctgga gtgcagtgat gcgatcacag cccactgtag gctcaaccac ccatgctcag  8341 gtgatcctcc cacctcaacc tcccaagtag ctgggatgac aagcgtgtac caccatgcct  8401 ggctagtatt tttttattat ttttgtagag atgaagtctc cctgbittac ccaggatgat  8461 cttgaactcc tgggcttaag tgatcctccc aacactgcct tctaaagtgc tgggtttaca  8521 ggcatgagcc gctgcacttg gcccacttcc tatgattaac aggatattat taatttagaa  8581 actatttagt acatggcaag cactcagtca aatggttatt aacggcbgtt tttatttcag  8641 gccaccaata tagcttcatc aaggggcaaa tacttatagc ttgggcttca gtgttggatc  8701 agacaccacc ttagaagttt tttgcaatca ttaactcctt aagtaagaag ggaactcttt  8761 ttgtaggatt gctttgggga atatgtagcc ccaaggcagg ggctgtactc tgagaagctt  8821 gggtagagtt ggagactgtt agaaatggat agacacataa aagcatttag accaatctgt  8881 tcattttgca gatgaggaaa ttgagtccta gaaaaggcaa gtgacttgtt caagatcaca  8941 cagccaatga tgggagggta ggactcaggg cttgaggatc agtttcagaa tgcagtgaaa  9001 ttgttatccc atatttcttt caaatcagta tagggacacg gaacactaac aacataggcg  9061 accaatgggt ctagggagga aaagatgaaa gctgtaggta agtgggagtt tggataacaa  9121 tgagatgttt ttctggagtt cctgacaatg cctgaaaaaa aaagtcagga ttttaagctt  9181 cagtcaggct caaggtcgag tcctcccact ccagtccctc ctcagacagt aaaacttttc  9241 aagccaagga catacatata ggtgggggca tttgacagtt ggctcatctc cccaccctcc  9301 aaattattta tatttctagt ccttcagttt agcactccta tttaccccag gattgtaatt  9361 cattgcctct ttccctggcc atattcctcc atcctttttg tttctcccat ctcttttctt  9421 cctccatcac ccccactgct gagcttggct acacttggct agtagtgcag gttgggagaa  9481 cacagagtcc tatcacagac tggaggacta ttatttaatc acaagaatgt tgtctttttt  9541 ctcctaaggt agcactctgg ggacggtcat tgctgtcttt attccctcac ccccccacca  9601 cccctgcact ggattagaca catgaaatgt gcctatctct gagatgaaag gagcaagaac  9661 tgcttcctcc ccactgacct tttgcctgcc catccttgga gatacctgga gttggcaggc  9721 tggaggccta gcagcatttg cagtcagtgc cgctgcctct gggtcagccc aggcttggct  9781 ccttggctgc tactgatgtg ctgccagcta ggaatattaa aaaccattca ttgaacgcac  9841 aggatgcttt ataaaatcca acatgcbgtt tacagtttat aaattaactg ccttgggaag  9901 aggcatttga cttattctcc aaggcatcta gttgactaga tccaattgga atcctttgag  9961 ttcctgggaa ggggctactt aacacttcac actttctaaa ttagacctag agtttcttgc 10021 ttttctgatc ctagtactgt atgaagtttt atctagggtt atctagcaag ctttcttcca 10081 cttataaatc tttgatgttt ttgcaatttc tttgatagag gctttatgtt ctactatctt 10141 cactttattt atgcttcata ccataatttt ttaaaaaatt acaataaata tcaagtaatt 10201 ctggctgata tactgactcc attccaaggt cattatattt tatttgctta acttggtctt 10261 cttagaaatg atgcaatgaa tactggatac aaattagatg ttcagagagt ttatcaatgt 10321 gtctaaaaac catccaggaa aacaacaggc caagactctg cctgcagagt cagtgagcta 10381 gaagagggat cgaggatagg aactatattt ttcccctgac cctatctctt atctgctaga 10441 gcaaaaggag acacacagta ggtgctcaat aaatacatgt taaaaaatat ttgttgaaag 10501 aagccacaga agggaatatc agtatacatt agtattgaaa acagcctagg gggaaatatg 10561 gatactgaag caccaccctc ctgtgcctgg caagcaaggc aagaataagg ccattcttgg 10621 cacataccac ttagcctgtt gctgagataa cttgcgtgaa accagcactt taccctctgc 10681 cagccagaag gtcagcccaa gagtgagctg atctgtgggc acaacaccat ctctcaccca 10741 ggaggcbjgg cccgctgtaa gctctgctat attatttccc tgaggatgac aggtggggaa 10801 atctgggcac cagttgttct tttccactgg tatcatttgg aaggtagctc caaagtcggg 10861 cacgccagcc tacgtgcctc tcctgccggc agaggctcca cattggagct attagaatgt 10921 gggctctgta cgtcjgccaa gtccatgtct cagagactgt atccagagca tagcgtggcc 10981 acagggctac tgagttcagc aagagagtca ttctcttgtt caatccatta ttgcctgggc 11041 caaggttcta agtcttcgta ggcagcattt gattttatga cacgtcttaa aaaattaagg 11101 caaactggaa ttaatttagt tttgagaaaa caacagaagc tgctacaagg cagagataat 11161 tctaggctgc cagaaagtgg tgatctcagt ggtgtacatt ttcttaattc ctgattttcc 11221 tctttgtgag gtcttcctcc cactcccata ctttgcacat tctcacctat gcacaccctg 11281 agcaacacaa tgttgacaac ttgacttagc attgctcttt tcttaagctt tgttttcatt 11341 tcttcttcaa tacaacagtg ttggttcatt caatttgaac actcaaggca aaaaaaaaaa 11401 aaaaaatccc aggttatgtt ttcagaatct tacctttttg tttttgtttt gagggttctg 11461 tgagttttgt ggcatattta cattgttgct tacattctta tttcagaatt taagataaaa 11521 actgggcaac aactctcacg ttttctgagt gtgttgaaat gaaaaatctg tttcttagaa 11581 ttaatggtaa agcaacattt cctgtcaatc tttcattctt taatattact tctgggttca 11641 gctcaccatc tctaaagaga aagccagatg atcaagttac attgtatgtg acattaacta 11701 tctctttatc tgtgtaaatg tcataatatc tgcttgcaaa gtgttttatt catttttagg 11761 aaaaaatttt aaactgtgct tgcaattcag gatggtgcta ctaggtggca gtaatgtaca 11821 agaactatgt ggtcgccctg gaagagtatt tgactaagag actagcatgc cttcccgtaa 11881 ttataagaaa taaaaatata atatttttaa aatactcaaa ctggcacaaa cagtaaacat 11941 ccattaactt agttaccata tttaagctga gcttttaaaa gagaaagcct tattttttaa 12001 tgaaatttta aataaagtat acattcacaa gctcaaaaat ctaaaaatac gaaaagatat 12061 atagtgaaaa gtctttctct catgcctgtc cctcaactac cacaggtaac taattttgtt 12121 agtttcttgg gtatcctttc agagctttgc tatacaaata tgtgttttta tctctctcca 12181 ttttaactca aatcaataca tagagtttct gcatccttcc atatatagtt ggttagtata 12241 ttgttgtgtg aacattttag aatataatta accagtcccc tattaatgga tatttcatgc 12301 tgtttccaat tttatgctat ttcagccatg tgctcatgtg atttcacatg taggataatt 12361 cacagaagtg gaattgctgg gtctaaatta tatacatttg catttttaaa aggtattgcc 12421 agattggcct ctacagagtt tggaccaatt tatactgaac tttctccaaa atggacttgt 12481 tttcccacag ccttgccaat agggtgcatg atcagacttc ggaatctttg taaatctgat 12541 tggttgaaca atgtatttca aagtacttta attttcattc tcttaaatga gacttttatt 12601 ctcttaaatt ctcttctatc tttaagggcc ctttatattt cctttttctg tggagaaagt 12661 ggaaatgcca ataaatacaa cgatgcatac acatgtatag ggttttgtta ttgatgtagc 12721 ttgtttttgc catcatgctg tacatgatgt tctttaattt gctttgctca tttaaccata 12781 cctcctggcc atggctctga agagaagttg ctggcagtgc agaagaaggg ccaggactgg 12841 aatgtctgct tctctcttca tccttttgcc attgactcct gggggaaata tctgtagacc 12901 gaagcagtga aatctaatca attctctttc tgacactaat taaggcttca aagagacaga 12961 taaccacttg ggataattta gtcacagtga aacttgggaa atggtcagta atatttcatc 13021 ctctgaaagt ggaccccaag aaagttctgg ctctttgagt tgttgtcttg gtaattttca 13081 gggtaacgtg tataggaaaa cccagattat gcagatgaaa agaaaacaaa catgctcttc 13141 tgcatccttt gcagatttga aactttgggc acaggtttga tttatttcaa tgagatgttg 13201 ctattagcat gaacataaag tggtgcaaag ttgtgctgga atatggtctc gtcaactttg 13261 ggctcactgt ctgcatatgg agatgatagt aactgaatcc atagttatca agtggtggca 13321 ttttagaaca caaagggaca gcagatgcca tctctgtcaa ctccttccct ctacagatga 13381 ggaaacttgg gctagaggag gttgaatgac ttgtgtaagg cttccccagc taattaatgg 13441 cagtgccagg actcaagtcc aggtgggttc cctcattact ggtccttgcc cttcctgcaa 13501 tttataggac ttccctgagg cacatgtgct gaggctttgc tattgccagg gattctgtgc 13561 tctgaaacag ccctatctca cacacccctt tccacttagg atcccctacc tcacacttcc 13621 aagacagcta attgaggcta aatgggtctg atgccattct attagtgcaa aataaattgg 13681 cttatgccaa cttgaactcc taatcttgat tttatcaaca ctttgccctg tttattcaga 13741 ctgttcatga gtaggaagtt aaggaaaatg ttgcctatga acaaaatgat caaactttta 13801 tctgaaatac ctttgaaagt tttcccgaag ctttaattat catgttcctt ttgttttgga 13861 tgtaatagca ggccctccca attttcctaa atgtttgaaa atatttttga tactttctgt 13921 cttctgttgt ggttaaaaaa aagaaggcac cagtgttggc tatgcctggg gagttagtga 13981 ggtaatctgg agagatctct ggaccccagt cctttgtcca agaggtatgg tcaaaagaac 14041 aaagcaaatt tcagaaaaac cggtataata tgatcctatt ttaatggtaa gtctgttcca 14101 acaactgctt tctttttcga attacaccat gtgcccaggc tacaaaggct ctgcagaaat 14161 gtgactctgt tggcaaatac gcgtgtgata ccttaaccat gctggaggcc agttagcata 14221 atgbitattt cagatgcagt ttgtcatcag tgcbgggtgc tatggggctt aaaacaaaaa 14281 caggatgagc ctagagcaca gaagtggaaa attaggtggg tgggtgagta tggacttgga 14341 aatggaaaat gtgcttccct gtgggacatg gcttgtgttc attagtgctg acctgcctcc 14401 tctctagccc tgtaagctga cgctgacacc aaagcttgct gagaaactga atagaccctc 14461 ccgccccgac caaccaagga caaagatgag accacccaat tcggttacgt tgttgccaga 14521 acaacatgtt taatctttaa catgggttca aactattctt ggccctagga acatggactt 14581 cagcaattaa agtcaacatg tgcttccatt aaaccattgt gtccacctcc aaatggttat 14641 aaatatgtag cataagctat gggagttggg gtggaatgga tgacagcctt tgctaatgac 14701 gctctagaaa ccaatattct cctctcaaaa taacatggaa aaattctact taatacctcc 14761 tgggttccat tagtggttct gggtaaataa ttctggggaa agtaatttct gttttcattc 14821 cagctgtgca gcagatactg tgatgatgga ttgcaagtgc aaagagtaag acaaaactcc 14881 agcacataaa ggacaatgac aaccagaaag cttcagcccg atcctgccct ttccttgaac 14941 gggactggat cctaggaggt gaagccattt ccaatttttt gtcctctgcc tccctctgct 15001 gttcttctag agaagttttt ccttacaaca atgagaaaac atgtactagc tgcatccttt 15061 tctatgctct ccctgcbggt gataatggga gatacagaca gtaaaacgga cagctcattc 15121 ataatggact cggaccctcg acgctgcatg aggcaccact atgtggattc tatcagtcac 15181 ccattgtaca agtgtagctc aaaggtaaga ccaaggtctc tgtgaggaga gcatttccct 15241 cagaaacagg caagaagcca tatttctttg tcaggggatg gagaactaag atcatagccc 15301 aaacttaagt gatgtggctg gcccacaggg cttgtgggag aatgaggctt ttagaatttc 15361 cccccgtgct ttgcactgtt atcagtaaaa gtgcctaatc aatcatgtgc acacccatcc 15421 agtgggacag gtgtcctttg tccctggctg tgatgtttat gagtggtagt gtgcttttcc 15481 aaaaaagaaa aatggagttt acaagtcatc ataactctct agctccatca tcaataaaga 15541 ggaagagaat gcaaagaatg cgattgagca gtggaacata cttcttggag ggctctttaa 15601 agagattctt ggtgaaataa ctggctttgt ggtctgagcc tttcttcagg tgctacattt 15661 ctgttcaaat gatttcaaaa gataagatgg caatatgatc atttatcatt tttacattgc 15721 ttatccaaat cgttctcatt tggaaaagga tgcabitttc ttgcagaggc agtccgtgcc 15781 tcagtggtgt gcaagggaat atcatgctta aaaggccacc aagagtggcc agctacatgg 15841 accacccaga agggaggcac attgtagggt ggaacatacg agatctcacg actgtcactg 15901 cccctaaaca ggcacaatga atgaaatttg tccacacttg gtaaataata atttgtttag 15961 cccaacctca gagattttta catttagttt tgagatgaaa atcacttaaa cattctcgta 16021 tggcaagtaa tttttgaaat taccagtata attaagaatt ttttatagta tcaatcacca 16081 gaattaagac catataagcc aatccctcca ctctccattc aaaaacatta tgacttttgt 16141 atgccttgaa aatttccatt aatttctctg attatagctc agtgatgatg attcatttta 16201 gtttaggagg atcagaattc gagttaaatc attttaacca ttatattaat aagatctatg 16261 actgbjggaa aaaatagaga ttttccactt aataaaaact ttctggctct tatttgtgct 16321 tgtagaacca aaaaaaaatg gagtaaatag atgaacataa atttttgcag ggccacaatt 16381 ccttcttagg aaagggaaac taaaacaaat tgagaaaaaa catgagaagt gcttttacaa 16441 gtgtgattgc tcagaaattg tgggcccatg taaggttgac tgcagcaatt attagtttct 16501 ccttccctcc cccttcagaa acagacagca tgaatattta gtgattttat tccatggata 16561 atttctttcc gtattgagtt gtcctccata atcgtgattc ttttttaaaa aaaggaatta 16621 aaattatttc aaagaaagtg tcactatgat gatagaaagg aacaaagaaa taggagcatc 16681 tataaaaact agaaaacaat ctggaaagac tggacaaaat gatggaggag tactttggca 16741 acaatcacat taatctagcg aaggtcaaag aagagacatc atgaactcaa accgaagaaa 16801 ttcacatgtg aattctgagc atgagtctta gaaacagact ttagtgtact gttattcacc 16861 tttgtttctt ccagaaagcc atggcaaata acagcgcaaa attgtgatag caggagaaat 16921 gtttgtaatt tcatgggaac aatctgtttt caaacatccc aaactatccc aaatatagca 16981 atagttttat gtaaatggtg cttgcaatta taaacctttc ttccctggcc ataaaatatg 17041 cctggcaaaa tctcaactac ccagaccttt tctaggttag atttttctct atgtatccag 17101 gagcaaaact gttttcattt ggaaatgttc tataattctt aactcttaca ttctcgggct 17161 gatcttttct ctaatgggtc tcacttaatg aaattgtttg cctttagaga cttggataaa 17221 acatttagcc tatgtctaga aaagaggcaa caacaatcta ccctagcttc tttttacaaa 17281 gaaaagactg ggatagattt ttttgtctct ataaaaatta tcccttgaca tcatgttcaa 17341 gggtcattat ttattaaaca tgtgcctact gtttgcctgc caattgttaa tgctttctga 17401 ctcacattta tccattatct ggccttgtaa aggcaagaaa gggagaatgt gacccaggct 17461 cagggaaggg agtgtacctg cttgaacacc taatatatgt gtcaggcacc tcatattgta 17521 tattataatc attgccaaga aacctgtgat ggcaggcatt attattccca ttatcctggt 17581 aaggaaaact gaagcccaaa ataattagat tgcttgatat catatagcca gggagtggca 17641 atgtctgcct tacagcattc atcttcccac tacttggatc ttcatattgg aggaacacaa 17701 gtagaatgta ggagccatca catagaagtt caggctctgc ttctgatctg ctggcagtaa 17761 taatttatac tcagcaatgt ttctagaaaa aataaataat agtgaaagcc tttctgggag 17821 ctttcaatga gactgttcat cccagccctg aacttgcagc tggccagtcc taggtccctg 17881 ctgcccatct cctagcaatt ccggaaagga ctgagaggga gtcaggcaga aaagactggc 17941 cacagtggcc caccaaagag gacagtgtgg ccacagatta ggatgtgcct gatagtttta 18001 agtggtggca cctcctgggt ttgggtacaa aagatcctgg gagtagcagg ttcatttata 18061 atcttcatgg aagactaagt ttctctaaaa tttggagtaa aggctgtaga gcaaacaggc 18121 aaaagaccag ttgatagtgg aaacagactg cctggtggaa tctctatgag aactgaggca 18181 tgccaggctt tgaagtgaga gagacctggt ttccaattcc agctccatgg cttgccgaat 18241 gagtgacttt gaggaagttc agtaacttcc ttctttgtgc ctcagtttct tcccatgcaa 18301 aatagagctg tctacctgag ggtatgggta tgggtgttgg tgatttgtaa agcatccagc 18361 ggtgtccagc acataatagc catttaatag aagatattat gatcttgatg ataaagttat 18421 aaactaagca ggtgtttaga ctcaattttc tatttcagtc acaactgaga tctcaataac 18481 tgctgggatc tcctatagcc ttaaaagatt aggaaaatga accttattgt agttcttgtt 18541 aagcacaggg tggggcagaa gagcaaagta aatgtaagcc actgtgctgg gtgctaacag 18601 ggaggataaa agtaaaagag aaacagcccc gatatctgtc taaccttcct tcccagatga 18661 gtggaggaag gaggggctgg agggggatga gttttggact tgggccaggg aggggatttc 18721 aggaatggag ggtgggaaag caaactggca gggaagacct ggaaagtctc agttgggtga 18781 ggagtggggg atgctggccc caggccaggg catggaacca gggcatgact atctgaaccg 18841 gtaagggcca caggagcagg tggggaactg gaagagcaac aacaaaggat aaggaggaag 18901 aggtttggga gacaaaacct aggaaaagag gacctggtat gctaagggct gagtcctaac 18961 agcttcctaa caggaccccc aagccatctt ctactgctac ccaccaagct catggtgtga 19021 taggagaaat ggagggagtc aggaaaattg tgtttataat acaatagact tcttgagaga 19081 tataatttga tttttttaaa aggaacaaat ttatactgag tgcctaccat gtccaggtgc 19141 tgtggaaggt gctggagact ctaaagtgga aagaaagaaa aaagagacaa tttttttgcc 19201 ttcatgatgc ttacaagaaa atggggagag agggaggagg ggtgttctgt gcacaaagat 19261 cagtttgtat ctgtttgatt catgaccgga gtgaagggac cagtttctag ttggagtgag 19321 ctgagttccc atccaccctt tcaaagcccc caccatctct ctgctgcttt gttccctggt 19381 tgcaattttc ttggtgccct cagcctagca cagatctttt ggaggttgac ctgggtccct 19441 gaagatgagc ggagttatga ggctgcccgt ggggaaagaa tgggagaaga agcatgggtg 19501 aatcttgttc ctgaggttat agagggtgtt tcaagaggtg ccatggaaat aagggtgcat 19561 agtgttcact gctgcgaaaa aggcaaaata cttttccact cbitcggagt aaaatcgcaa 19621 aaatgctctt ctagggtggg acaggtgggt ctttattctg atgctaatgg tgacatctgg 19681 tcagtcaagg ctcttggaag attcagctct gcataagctt ggggatggtg aagctaatgt 19741 cccaagaagc ccacaagaaa aagttagact tgtatgtcta tggatatggt caggggtttc 19801 tgaggcaaat caatgtagat aaggaagtct gtgagttggc atatgcttga ggaaaacatg 19861 gtatcaggag gcaggtatta tactggttta ggtcagggct ttggtttcag atagaccttg 19921 gtttgattcc agctctgcat tttaccacct atgtgagttt gggcaagtta ctggaactct 19981 ctaaagcttg agtttcctta tctgtcctaa tagtgtagat cataacagta ctttcttgta 20041 gggttgttgt aaggatgaaa taactcacat tgcaagtgct caataaatgt tcttattagc 20101 gaaatgatgg ttatctagtg attcatctag agcacagccc tcaaacttga atgggtccag 20161 agacctgcta ctcaaagtgt gggcaccagc ccagtaggac tgacatcaac tggaatctga 20221 tgggaaatgc agaatctcag gctctaggcc agaactactc aatcagaact tgccttttaa 20281 caagatccta gatgattcac acgcacattc cagtctgaga agctctgatc cggaagagat 20341 caggagatgt tcaagtgctg aaacacaagt aaggcatggc agaagctaaa atgtgaagta 20401 ttgagagtaa accaggagag cagatggtta ttccttccat cccttaagga tcttatcttt 20461 caaacttctg ctttaccact tcaacacaca aaacagagat agatttcctt ctaggagtgt 20521 gtgtgtgtgt gtgtgtgtgt gtgtgtgttg agaacatcaa tggttcaata attgcttcat 20581 agtcttttct tccaggaaag agcatttgaa tttggctaca gagaatagat aggtgggatt 20641 ttattaggca gagcaaggtg gaaaggacat atttgggaga cagaagacat aagcaaaggc 20701 aagaggcagg agaattcagg gcactttctt ggactcctaa gtagttaagt ttgactggag 20761 tagggagtgg gtagtagagt gatgagaata gttgtaagta agactggaaa tacatgtgaa 20821 acctgggtca tgaagggcct tgactcctct tcaagatttt ggattttatt ctgaactact 20881 gaaggcattt attgtacatg tctgtgcatt cttcttgcac aaacagtcca gctcccaagg 20941 aagaggggcc cagcccattg gaggtggccc cacgtccttc agtgcctgga gttcttgtcc 21001 ttcagagtgg gcbgggggtg gagctggaca tcctgaaaac ttttagtgag attgcaatca 21061 gatgagctca tttacaaatg gccctacgct gttgacttgg tcattttatg gacagtgcta 21121 atggcccagt cagttaggcc tacgtttggt tcacctgtgt atacatcact tggatattat 21181 gtcccatatc attgttggcc cttctgagtt aagttcgttg gcacagattt actttgtcca 21241 cccagactga aactgcacct ctgaagactc catcacggaa ggtgactctg tgaataactg 21301 cttagtcaac ctaatagatg atctagatga gagattagca aatttaacac tactccaagg 21361 tgaggtatca agcagctctt cccacataca gggagatggg gggagaacag actaaggaag 21421 atcttggact ctctctctca ttagagaaat gggggtggga attagggact agcctgtgta 21481 ctactgacct atggcatagt ctctcaaaac ccatttcaga gccaggcaca gtggtacatg 21541 cctgtagtcc tggctacaca ggaggctgag gcaggaggat cccttgagct caggagttta 21601 aggctgtagt gtgctatgat catgcctgtg aataaccact gcactgcagc ctggacaaca 21661 tagcaagact ctgtctctaa aaacaaaaca aaacaaacaa acaatcattt ctgatagttt 21721 actttgcctg tcaaaatgaa gagcaggtag gatagaatca aaagctttaa aaaaatcaaa 21781 acagcttaca gctgctattt tctctctgcc tctgcgatca ttcagagaaa ataaattcac 21841 tggtctagtc caacttattc ttccctaagc cctgctgttt tttttttcta gtatttcata 21901 ttgccttggt ggttgctaag tgattgttgg atttagcccc agtatattct cagataacta 21961 tgccaataat ctataattac cagaattcat cttttctccc ttttggaaag atggactggc 22021 tatttttttc ttgtaaacct tgggtgttta attctgccct acaggatgat gtcagagata 22081 atagctggtg agtctttaat aataactgcg aattcctaca atattgtaag gtaaacgtca 22141 aaaggtttca tgcatatata tgtatctttt aatctttcat ttgaacagtt tcacttttta 22201 tgatcttgct gttggttctg gaattatagg acaaattttt cttttctttt cttttctttt 22261 tgagacaggg ccttgctctg tcactcatgc tggagtacag tggcttgatc atagcttcct 22321 gcagcctcta attcctgggt tcaagtgatc ctcctgcctc agctgccaaa gtagctggga 22381 ctacaggtgc acatcaccac gcctggttaa ctttttattt ttttttttag agacacggtc 22441 atgctatgtt gcccaggctg gtctcaaact cctggggtca agtgatcctc ctgcctcaga 22501 ctccaaagtg ttgggattat aggcatgaga caatacacct ggcccagggg atttttttct 22561 ccatcactta acatgaaatt caccaagcaa aacctcttac ataaccatgg gaccaataat 22621 ctcagattct ccattcccct ccccaccttg atattaggat tatgcagctt aatgagtcaa 22681 gctgtcccac cctacccacc tattactccc actcccagga taccaggagt tttgtatggg 22741 atacataaat gatccttttt tccattccgt taagctgtat gcaaattgtg tgtgtgctta 22801 tgtacatttt tctggggata actttggtag ttttcatcag attcttaaag gtgtctgttt 22861 gctaaagcca gattaagagc tactataaag aacacatagc ctccgttatt ccagcccaat 22921 ctttggaaat agagattatc agaatgggta catcctaata tttgccgcaa atgactctga 22981 agatgcggat gcaattacat aaatcccagg ctccttcaac atataaaccc agaagtgtga 23041 tttcagggcc ccagacatgc cctgtctcta cttcattctc ttgtcccaaa ttgcagcacc 23101 cagaatattt cttcctaagc attactcagg ctatcctatt ttcttattca gaaactatat 23161 tcctgttctt tagctatttc ctgcacaaat caatttcttt tttttttttt tttttttggt 23221 agtcatttta atttacttct tggtttcaat ttggattgac tttctgcatt ttgctactgg 23281 tagaattgca atgcattggg ccagtggtag accactacct gtcaggagaa atttcttttg 23341 ttctttggtt tttactcgca catcacagtg atgggcgtca ttcagtggtt ctaaaccctc 23401 agtacactta gaaatcacct aagaagcttt gaaaaccatg aaagcctggt ccctatctcc 23461 aaggatttta attcaatcga tctgaatgag gcctgggtgt tgacttaaaa aaaatgcaac 23521 atgcattgag ccactggtct aatctagcag gaattggcaa cgagtgtgag ggtctttcaa 23581 aagatgctgt tttacctggc taaggttgtg gcatgcccac agagtaacca cctccttttc 23641 tttccccaga tggtgctcct ggccaggtgc gaggggcact gcagccaggc gtcacgctcc 23701 gagcctttgg tgtcgttcag cactgtcctc aagcaaccct tccgttcctc ctgtcactgc 23761 tgccggcccc agacttccaa gctgaaggca ctgcggctgc gatgctcagg gggcatgcga 23821 ctcactgcca cctaccggta catcctctcc tgtcactgcg aggaatgcaa ttcctgaggc 23881 ccgctgctgt gtgtggcttc tggatgggac aactgtagag gcagttcgac cagccaggga 23941 aagactggca agaaaagagt taaggcaaaa aaggatgcaa caattctccc gggactctgc 24001 atattctagt aataaagact ctacatgctt gttgacagag agagatactc tgggaacttc 24061 tttgcagttc ccatctcctt tctctggtac aatttctttt ggttcatttt cagattcagg 24121 cattttcccc cttggctctc aatgctgttt gggtttccaa caattcagca ttagtgggaa 24181 aaagtgggcc ctcatacaca agcgtgtcag gctgtcagtg tttggtgcac gctggggaag 24241 aatttacttt ggaaagtaga aaagcccagc ttttcctggg acatcttctg ttattgttga 24301 tgtttttttt taccttgtca ttttggtcta aggttgccat tgctgctaaa ggttaccgat 24361 ttcaaagtcc agataccaag catgtggata tgtttagcta cgtttactca cagccagcga 24421 actgacatta aaataactaa caaacagatt cttttatgtg atgctggaac tcttgacagc 24481 tataattatt attcagaaat gactttttga aagtaaaagc agcataaaga atttgtcaca 24541 ggaaggctgt ctcagataaa ttatggtaaa attttgtaag ggagcagact tttaaagact 24601 tgcacaaata cggatcctgc actgactctg gaaaaggcat atatgtacta gtggcatgga 24661 gaatgcacca tactcatgca tgcaaattag acaaccaagt atgaatctat ttgtgggtgt 24721 gctatagctt tagccgtgtc acgggcatca ttctctaata tccacttgtc catgtgaaac 24781 atgttgccaa aatggtggcc tggcttgtct tctgaacgtt tggttcaaat gtgttttggt 24841 cctggaggct caaattttga gttattccca cgttttgaaa taaaaagagt atattcaaaa Mouse Mature NDP Protein (NCBI Accession No. NP_035013.1) (SEQ ID NO: 23) KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPERSSCHCCR PQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS Mouse Mature NDP cDNA (SEQ ID NO: 24) aaaacagacagttcatttctgatggactctcaacgctgcatgagacaccattatgtcgattctatcagtca cccactgtacaaatgtagctcaaagatggtgctcctggccagatgtgaggggcactgcagccaggcatcac gctctgagcccttggtgtccttcagcactgtcctcaagcaacctttccgttcctcctgtcactgctgccga ccccagacttccaagctgaaggctctgcgtctgcgctgctcagggggcatgcgacttactgccacttaccg gtacatcctctcctgtcactgtgaggaatgcagctcc Rhesus Monkey Mature NDP Protein (NCBI Accession No. NP_001253901.1) (SEQ ID NO: 25) MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQ ASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS Rat Mature NDP Protein (NCBI Accession No. NP_001102284.1) (SEQ ID NO: 26) KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCR PQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS Chimpanzee NDP Protein (NCBI Accession No. XP_016799622.1) (SEQ ID NO: 27) KTDSSFVMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHC CRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS

Trio Rho Guanine Nucleotide Exchange Factor (TRIO) and F-Actin Binding Protein (TRIOBP)

[0137] The TRIOBP gene encodes “trio Rho guanine nucleotide exchange factor (TRIO) and F-actin binding protein” (TRIOBP), a protein that is expressed along the length of the stereocilia actin filaments and in the stereocilia rootlets of the inner hair cell. TRIOBP is important for the stability and rigidity of the stereocilia of specialized hair cells in the inner ear (see, e.g., Kitajiri et al. (2010) Cell 141: 786-798; and Zhao et al. (2015) Curr. Opin. Neurobiol. 34: 172-179).

[0138] Stereocilia, which are about 10-50 μm in length, are important for hearing and balance. Stereocilia play a mechanosensing role in hearing. By bending in response to sound, they form a structure for mechanoreception of sound stimulation.

[0139] The human TRIOBP gene is located on chromosome 22q13.1. It contains 24 exons encompassing ˜80 kilobases (kb) (Hirosawa et al. (2001) DNA Res 8:1-9; NCBI Accession No. NG_012857.1). To date, there are three known families of TRIOBP splice isoforms: TRIOBP-5, TRIOBP-4 and TRIOBP-1 (see, e.g., Kitajiri et al. (2010) Cell 141: 786-798). While TRIOBP-1 is ubiquitously expressed, TRIOBP-5 and TRIOBP-4 are expressed predominantly in the inner ear and in the eye. TRIOBP-5 gene (NCBI Accession No. NM_001039141), the longest isoform, contains 24 exons, and the translation start site for the TRIOBP-5 isoform is found in exon 3. The TRIOBP-5 protein has a molecular mass of ˜218 kDa. The TRIOBP-4 is gene encoded by exons 1-6 and is expressed from the same promoter as TRIOBP-5. The TRIOBP-4 protein has a molecular mass of ˜107 kDa. TRIOBP-1 (NCB1 Accession No. NM-007032) is encoded by exons 11a-24, has a molecular mass of ˜72 kDa, and is translated from a start site in exon 11a (see, e.g., Siepel et al. (2001) J. Cell. Sci. 114: 389-399).

[0140] Various mutations in the TRIOBP genes have been associated with non-syndromic hearing loss (e.g., profound, prelingual deadness DFNB28 (MIM #609761) (see, e.g., Riazuddin et al. (2006) Am J Hum Genet 78: 137-143) and age-related hearing impairment (see, e.g., Hoffmann et al. (2016) PLoS Genet 12(10): e1006371)). DFNB28-causing mutations have been predominantly found in exon 6 of TRIOBP, an exon that is present in both TRIOBP-4 mRNA and TRIOBP-5 mRNA. DFNB28-deafness can be modeled by generating TRIOBP-4/5 deficient mice, in which mouse exon 8, the ortholog of exon 6 of human TRIOBP-4 and TRIOBP-5, is mutated/deleted (see, e.g., Kitajiri et al. (2010) Cell 141: 786-798). Nonsense mutation (c.5014G>T (p.Gly1672*) in exon 9 of TRIOBP-5) and frameshift mutations (c.2653del (p.Arg885Alafs*120), c.3460 3461del (p.Leu1154Alafs*29), and c.3232dup (p.Arg1078Profs*6) in exon 6)) were found in Dutch families with congenital and moderate hearing impairment (see, e.g., Wesdorp et al. (2017) Hearing Research 347: 56-62). The nonsense mutation found in exon 9 was the first disease-associated mutation that was present only in TRIOBP-5.

[0141] Additional exemplary mutations in a TRIOBP gene that have been detected in subjects having hearing loss and methods of sequencing a nucleic acid encoding TRIOBP are described in, e.g., Shahin et al. (2006) Am J Hum Genet 78:144-152; Diaz-Horta et al. (2012) PLoS One 7: e50628; Gu et al. (2005) Clin. Genet. 87: 588-593; and Table 1 in Wesdorp et al. (2017) Hearing Research 347: 56-62. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

[0142] An exemplary human wildtype TRIOBP protein is or includes the sequence of SEQ ID NO: 28, SEQ ID NO: 30, or SEQ ID NO: 31, SEQ ID NO: 32. Non-limiting examples of nucleotide sequences encoding a wildtype TRIOBP protein are or include SEQ ID NO: 29, and SEQ ID NO: 33.

[0143] In some embodiments of any of the compositions described herein, the TRIOBP protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 28.

[0144] In some embodiments of any of the compositions described herein, the TRIOBP protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 30.

[0145] In some embodiments of any of the compositions described herein, the TRIOBP protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 31.

[0146] In some embodiments of any of the compositions described herein, the TRIOBP protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 32.

TABLE-US-00009 Human Full-length Wildtype TRIOBP Protein Isoform 5 (SEQ ID NO: 28) MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGC QSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSAT PDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGG GGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRI TQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPR TSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRD NPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATR DNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPN RATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSP NRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQADDPRASS PNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTS SPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQAD RTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLAPTQSDGPRTSS PSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSP VYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCI GHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLF QDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLH GSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPP PRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLARQSSP APSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQAPLESGQAGP RQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQP EAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDL LGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGW AEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQ PEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLAWARP DLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVT EYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLK AGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRK WFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRG PPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQ RHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRE LQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCG RSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLK EHLRLAMAALQEKESMRNSLAE Human Wildtype TRIODE Isoform 5 cDNA (SEQ ID NO: 29) atggaggag gtgcctgggg atgccctgtg tgaacacttt gaggccaaca tacttaccca gaaccgctgt caaaactgct tccaccctga ggaggcccat ggagcaagat accaggagct caggagccct tcaggtgctg aggtgcccta ctgcgacctg cctcgatgtc cacctgcccc tgaggaccca ctcagcgcct caacctccgg ctgccagtct gtggtggacc caggcctcag gccagggccc aagaggggcc catccccctc agcagggctc ccagaagagg gtcccacagc tgcccccagg agcaggagcc gggagcttga ggcagtaccc tatctggagg gcctgaccac ttccttgtgt ggcagctgca acgaggaccc cggctctgac cccacctcca gccctgactc cgccacccct gatgatacca gcaactcgtc ctctgtggac tgggacactg ttgagaggca ggaggaggag gcccccagct gggacgagct cgcagtgatg atcccgagga ggcctcggga ggggccgaga gctgacagct cccaaagggc tccgtctctc ctcaccaggt cccctgtggg aggagatgct gcaggccaga aaaaggagga caccggcggt gggggccgga gcgcaggaca gcactgggca aggctccggg gagaaagcgg gttgtccctg gagcggcacc ggtcaacact gacccaggct tcctccatga caccacacag tggacctcga agcaccacgt ctcaggcttc tcctgcccaa agggacactg ctcaggctgc ctctacacgt gaaatcccca gagcctcctc tccccatcga atcacccaaa gggacacctc cagggcctca tccacccaac aggaaatctc cagggcctca tccacccaac aggaaacctc cagggcctca tccacccaag aggacacccc tagggcctca tccacccaag aggacacccc cagggcctca tctacacagt ggaacacccc cagagcttcc tctccctcac gaagcaccca actggataac cccagaacct cttctaccca gcaggacaac ccccaaactt cttttcctac ttgtactccc cagcgggaaa accccaggac accctgtgtc cagcaggacg atcccagagc ctcctctccc aacagaacca ctcaacgaga gaattccaga acatcctgtg cccagcggga caatcccaaa gcctccagaa cctcctctcc caatagagcc acacgagaca accccagaac atcctgcgcc cagcgggaca atcccagagc ctcctctccc agtagagcta cacgagacaa ccccacaaca tcctgtgccc agcgggacaa tcccagagcc tccagaacct cctctcccaa tagagccaca cgagacaacc ccagaacatc ctgtgcccag cgggacaatc ccagagcctc ctctcccagt agagctacac gagacaaccc cacaacatcc tgtgcccagc gggacaatcc cagagcctcc agaacctcct ctcccaatag agccacacga gacaacccca gaacatcctg cgcccagcgg gacaatccca gagcctcctc tcccaataga gctgcacgag acaaccccac aacatcctgt gcccagcggg acaatcccag agcctccaga acctcctctc ccaatagagc cacacgagac aaccccagaa catcctgtgc ccagcgggac aatcccagag cctcctctcc caatagagct acacgagaca accccacaac atcctgtgcc cagcgggaca atcccagagc ctccagaacc tcctctccca atagagccac acgagataac cccagaacat cctgtgccca gcgggacaat cccagagcct cctctcccaa cagaaccacc caacaagaca gccccagaac atcctgtgcc cgacgggacg atcccagagc ctcctctcct aacagaacca tccaacaaga gaaccccaga acatcctgtg ccctacggga caatcccaga gcctcctctc ccagcagaac catccaacaa gagaacccca gaacatcctg tgcccaacgg gacgatccca gagcctcctc tcctaacaga accacccaac aagagaaccc cagaacatcc tgtgcccgac gggacaatcc cagagcctcc tctcgcaaca gaaccatcca gcgagacaac cccagaacat cctgtgccca gcgggacaat cccagagcct cctctcctaa cagaaccatc caacaagaga acctcagaac atcctgtacc cgacaggaca atcccaggac ctcctctccc aatagagcca cacgagacaa ccccagaaca tcctgtgccc agcgggacaa tctcagagcc tcctctccca tcagagccac ccaacaggac aaccccagaa cttgtattca acagaacatc cccagatcat cttctaccca acaagacaac cctaaaacct cttgtaccaa acgagataac ctcagaccca cttgtacaca gcgggaccgc acacagtcct tttcctttca acgagacaac cctggaacct cctcatctca atgctgcacc caaaaggaga atctgagacc atcatctccc caccgctcca ctcaatggaa caatcccagg aattcatctc cccatcgtac taacaaagac atcccctggg cctcgtttcc cctccggcca actcagagtg atggtccccg aacctcttcc ccatctcgct ccaagcaaag cgaggttccc tgggcatcca tcgccctccg gccaacccaa ggtgacaggc ctcagacatc ctctcccagc aggccagccc agcatgaccc accccagtcc tcctttggcc ccacccagta caacttgcca tcccgggcca cctcttcctc ccataaccca ggccaccaga gcacctcccg aacttcctca cctgtgtacc ccgctgccta tggggctccc ctgacctctc ctgagccctc ccagcctcca tgtgctgtgt gcattgggca ccgggatgcc cctcgagcct cttcgccccc tcgctatttg cagcacgacc ccttcccctt cttcccagag ccccgcgccc ctgagagtga accgccccac cacgagcctc cctatatacc acctgctgtg tgcattggac accgagatgc cccccgggcg tcctcgcccc cccgccacac ccaatttgac cccttcccct tcctcccaga cacatcagat gccgagcatc agtgtcagtc cccccaacac gagccccttc agctccctgc acctgtgtgt attgggtacc gagatgcacc ccgggcctcc tccccaccac gccaggcccc agagccttcc ctcttattcc aggacctccc cagggccagc acagagagcc ttgtcccttc catggactct ctgcacgagt gcccccacat ccccacccct gtgtgcattg ggcaccggga tgcaccctcc ttctcatccc caccacgcca ggctcctgag ccatccctct tcttccagga tccccctgga actagtatgg agagcctggc cccctccact gactctctgc atggctcccc agtgctgatc ccccaagtgt gcatcgggca ccgggatgca ccccgagcct cctccccacc ccgccaccca cccagtgacc tagcgttcct ggcaccctca ccttcaccgg gcagctctgg gggctcccgg ggctcagcgc ctcccgggga gaccaggcac aacttggagc gggaggagta cactgtgctg gccgacctgc ccccacccag gaggctggcc cagagacagc cagggcccca ggcgcagtgc agcagcgggg gccgcaccca cagccctggc cgtgcagagg tggagcgcct cttcgggcaa gagcgcagga agtccgaggc agcgggggcc ttccaggccc aggacgaggg acggtcacag cagcccagcc aaggccagag ccaacttctc cgaagacagt ccagccctgc ccccagcagg caggtgacca tgctccctgc caaacaggca gaactgaccc ggcggagcca agcagagccc cctcatcctt ggagtcctga gaagagacct gagggagatc ggcagctcca ggggtccccg ctgcccccca ggacatcagc caggacccct gagagggagc tgcggacaca gagacctctg gagagtggcc aagcaggccc aagacagcct ctgggggtgt ggcagagtca ggaggaaccg ccagggtccc agggccctca tagacaccta gaaaggagct ggagcagcca ggagggaggc ctgggccctg ggggctggtg gggatgtgga gagcccagcc tgggggcagc caaagccccg gagggagcat gggggggcac ttccagggag tacaaggaga gctgggggca gccagaggcc tgggaggaga agcccactca tgagctcccc agagaactag gaaagagaag cccactcacg agcccccctg agaactgggg aggccccgca gagtcctcac aatcctggca ctctgggaca cccactgctg tgggctgggg ggcagaggga gcgtgtccat acccgcgtgg ctctgagagg cgacccgagc ttgactggag ggatctgctt ggccttctcc gggcaccagg agagggggtc tgggcccgtg tccccagcct ggactgggag ggcctcttgg agctcctgca ggccaggctg ccccgcaagg acccagctgg acacagggat gacctggcca gggctttagg gccagagctg ggtcccccag gcacaaacga tgtccctgag caggagtcac acagccagcc agaaggctgg gccgaggcca ccccagtcaa tggacacagc cccgcactgc agtcccagag cccggtccag ctgcccagcc ctgcctgcac ctccacccag tggccaaaga tcaaagtgac aagaggacca gcgaccgcaa ctctggcagg cctggagcag acgggccccc tggggagcag gagcactgcg aagggcccca gcttgccaga gctgcagttc caaccagagg agcctgagga gtcagaacca agcagaggcc aagaccccct gactgaccag aagcaggcag actcggcaga caagaggcca gcagagggca aggctgggag cccgctcaag ggccgactgg tgacctcatg gcggatgccc ggggaccggc ccacgctgtt caatccgttc ctgctgtctc tgggggtcct caggtggcga aggcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga gcctggagag cctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca ttggtttgtg ctgacagatt caagtctcaa atattacaga gactccactg ctgaggaggc agatgagctg gatggtgaga tcgacctgcg ttcctgcacg gatgtcactg agtacgcggt gcagcgcaac tatggcttcc agatccacac caaggatgct gtctatacct bitcggccat gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtac gtccaacttc agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacag cacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg gggtggccct cggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc gctgacccag gcttccccgc agcgggcccg caccccagcc cgcactcctg accgcctggc caagcaggag gagctggagc gggacctggc ccagcgctcc gaggagcggc gcaagtggtt tgaggccaca gacagcagga ccccagaggt gcctgctggt gaggggccgc gccggggcct gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcg agaagaagtg gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgct caaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa ggaggttcag gctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca gagtgcactg agatcccagg aggatggcca catccccccg ggctacatct cacaggaggc atgtgagcgc agcctggcag agatggagtc ctcgcaccag caggtgatgg aggagctgca gcggcaccac gagcgggagc tgcagcgcct gcagcaggag aaggagtggc tcctggctga ggagacggca gccacggcct cagccattga agccatgaag aaggcctacc aggaagagct gagccgagag ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagca gcaccagtca gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc gcagaagtgc ctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct gcgccgctgc cagcaggagg gccaggagct gctgcgccac aaccaggagc tgcatggccg cctgtcagag gagatagacc agctgcgcgg cttcattgcc tcgcagggca tgggcaatgg ctgcgggcgc agcaacgagc ggagttcctg cgagctagag gtgctgcttc gcgtaaaaga aaacgaactc cagtacctaa agaaggaggt gcagtgcctc cgggacgagc tccagatgat gcagaaggac aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagcca catcaagaca cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat ggccgccctc caggagaagg agtcgatgcg caacagcctg gctgagtag Human Full-length Wildtype TRIOBP Protein Isoform 1 (SEQ ID NO: 30) MTPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKG PLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEE RRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGE RRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVME ELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEAL KRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGN GCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIE QLKEHLRLAMAALQEKESMRNSLAE Human Full-length Wildtype TRIOBP Protein Isoform 4 (SEQ ID NO: 31) MIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQA SSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASS TQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQ DDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCA QRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPR TSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNP TTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQ ENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQ RDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQ QDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSS PHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPS RPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAP RASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAE HQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCI GHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDL AFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVE RLFGQERR Human Full-length Wildtype TRIOBP Protein Isoform 6 (SEQ ID NO: 32) MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGC QSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSAT PDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGG GGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRI TQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPR TSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRD NPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATA DNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPN RATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSP NRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASS PNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTS SPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRD RTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSS PSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSP VYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCI GHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLF QDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLH GSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPP PRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSP APSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGP RQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQP EAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDL LGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGW AEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQ PEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRP DLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVT EYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLK AGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRK WFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRG PPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQ RHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRE LQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCG RSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLK EHLRLAMAALQEKESMRNSLAE

[0147] A non-limiting example of a human wildtype TRIOBP genomic DNA sequence is SEQ ID NO: 33. The exons in SEQ ID NO: 33 are: nucleotide positions 1-102 (exon 1), nucleotide positions 601-709 (exon 2), nucleotide positions 4319-4492 (exon 3), nucleotide positions 13440-13579 (exon 4), nucleotide positions 16223-16424 (exon 5), nucleotide positions 18776-18947 (exon 6), nucleotide positions 26198-29516 (exon 7), nucleotide positions 36311-36425 (exon 8), nucleotide positions 37412-38455 (exon 9), nucleotide positions 41655-41732 (exon 10), nucleotide positions 43908-44045 (exon 11), nucleotide positions 54785-54841 (exon 12), nucleotide positions 57890-57997 (exon 13), nucleotide positions 58114-58203 (exon 14), nucleotide positions 58563-58672 (exon 15), nucleotide positions 60626-61151 (exon 16), nucleotide positions 62167-62277 (exon 17), nucleotide positions 68683-68830 (exon 18), nucleotide positions 71087-71189 (exon 19), nucleotide positions 72041-72200 (exon 20), nucleotide positions 72275-72388 (exon 21), nucleotide positions 74663-74749 (exon 22), nucleotide positions 75614-75777 (exon 23), and nucleotide positions 76796-79569 (exon 24). The introns are located between each pair of these exons in SEQ ID NO: 33, i.e., at nucleotide positions 103-600 (intron 1), nucleotide positions 710-4318 (intron 2), nucleotide positions 4493-13439 (intron 3), nucleotide positions 13580-16222 (intron 4), nucleotide positions 16425-18775 (intron 5), nucleotide positions 18948-26197 (intron 6), nucleotide positions 29517-36310 (intron 7), nucleotide positions 36426-37411 (intron 8), nucleotide positions 38456-41654 (intron 9), nucleotide positions 41733-43907 (intron 10), nucleotide positions 44046-54784 (intron 11), nucleotide positions 54842-57889 (intron 12), nucleotide positions 57998-58113 (intron 13), nucleotide positions 58204-58562 (intron 14), nucleotide positions 58673-60625 (intron 15), nucleotide positions 61152-62166 (intron 16), nucleotide positions 62278-6862 (intron 17), nucleotide positions 68831-71086 (intron 18), nucleotide positions 71190-72040 (intron 19), nucleotide positions 72201-72274 (intron 20), nucleotide positions 72389-74662 (intron 21), nucleotide positions 74750-75613 (intron 22), and nucleotide positions 75778-76795 (intron 23).

TABLE-US-00010 Human Wildtype TRIOBP Genomic Sequence (NCBI Accession No. NG_012857.1) (SEQ ID NO: 33)     1 cttccacctc ccgagcatcg ctctgattca ttgttaaaat aaagaggcca tgaccctggc    61 actcccaccc cggcagcccc tgtgcgtgga aacccagcca aggttagcac tgggcctcag   121 aaaagaggag ctggtagggg gaggcctaca ggaggggtag gggtcgaggg atccggggag   181 gaactggctg aatgcctgga tggagagggt cccgggtcca ttctctgggt ggggcatgtg   241 tagctgctta aggttttgat tattatatcc acatctcaag tgcattttag agaaggattc   301 tgcctattgg ttgtgggtag gggaggaaac gggagcagcg aggggcacgt ggagtagagc   361 cccctaccca cccccaggaa aatgagcggc gttctcctgc taggcgacgc tcctttatgt   421 ggccagacca ggagagaaac gcccaggacg ggcggggccg atgcgcccct cttccaccac   481 caggagtcgg gaggacgacc gcccggggag gatcagagac cctggggcca cggaaggacc   541 agtgggtagc cctctcccca ccgtgccttg ctgtcgcccc caccgcattc ccttctccag   601 gtctgatgat ggaggagcct tggccctggc tgtcccaggg gaggaggtga aattcctcag   661 ctctccacca agattggcca caaaagcctg atcccctgga acacagcagg tgaggatgga   721 tgtgggcagg tgacctgggg gcaccaaaag ctgcaggtgt tttgggatgt tgggttcctc   781 ccacccccca ccctccccct ggggctctgt gtgagtgggg aggccatctt taagtgattc   841 tcctgaccca gctccactcc agggcatgga tgttggtggc cttaggggca cccagaaagg   901 agaacccttg cacaagtaag ataccagggc ggccgggcgc ggtggctcaa gcctgtaatc   961 ccagcacttt gggaggtcga ggtgggtgga tcacaaggtc aggagttcga gaccagcctg  1021 gcccatatgg tgaaacctcg tctctaccaa aaatacaaaa aaattatccg ggcatggtgg  1081 cacatgcctg taatcccagc tatttgggag gctgcggcag gagaattgct tgaatccggg  1141 aggcagaggt tgcagtgagc cgagatcgcg ccactgcact ccagcctggg tgatagaccg  1201 agattctgtc tcaaaaaaaa aaaaaaaaaa agaaagaaag acaccagggt ttcagaaggg  1261 tatgatgctt cacacctgta atcccagcac tttgagggaa ggaggaggat tacttgaggt  1321 caggagttca ggagttcaaa accagcctgg gtaacactgc aagagccttt tttttttttt  1381 tttttttttt tgagacacac tgttgcccag gctggagtgc agcggggcga tcttagctcc  1441 actgcaacct ccacctcctg ggttcaagca attctcttgc cccagcctct tgagtagctg  1501 ggattacagg catgcgcacc acgcccagct aatttttata gttttagtag agacagggtt  1561 tcatcatgtt gggcaggctg gtcttgaatt cctggcctca agtgatctgc ctgcctcagc  1621 ctcccaaagt gctgggatta taggcgtgag ccaccgcacc tggccaagag cccattttta  1681 caaaataaaa aagaaaaaaa ttagctgggc gtggtggcgt acacctgtag tcccagttac  1741 tcagtcccag agactgaggc aggagaatca tttgagcccg ggagtttgag gttgcaagga  1801 gctatgatcg agccactgca ctccagcctg ggtgacagag caagaccctg cccccacctc  1861 cccaaaaaag acattagggg ccggatgcag tggctcacac ctgtaatccc agcattttgg  1921 gaggccgaag ggggcggatc acctgaggtc aggagttcac ctggccaaca tggcgaaacc  1981 ccgttgctac taaaaataca aaaattagcc aggcatgacg gtgcatgcct gtgatcccag  2041 atactactgg ggaggctgag gtagaattgc ttgaacccag gaggcggagg ttgcagtgag  2101 ccgagtgagc caagatcaca tcacggcact ccagcctagg tgacagagag agacttcgtc  2161 tcaaaaaaac aaaacaaaac aaaacgaaaa cacattagga tttctttttg gctaagttct  2221 gccacaaact tgctgtgtga ctttaggctg ttcacgtttg tcaaagacgt cgtcctcaac  2281 tctgaaaata cctggccagc tttttgcctc cctcgctgtg cttcccaagg gacctgtgcg  2341 agttggcagt atgatccagt gctcctcact tccacctccg agagagcagg gacacacaca  2401 gccctggatt tgaatcagcc actgcgacct tcagtgaccg aaggaacctc tctgagcctt  2461 agttgcctga tctaaaattg gcattaattt gatctacaat gcagctataa gacaaggaca  2521 ctcaaacttt ggggcgcact agaatcacct ggggaatcac tttttttttt taagacagag  2581 tctcactctt atcacccagg ctggagtaca gtggtgcaat cttggctcac tgcaacctcc  2641 gcctcctggg ttcaagtgat tctcctgcct cagcctcccg agtaactggg actacaggtg  2701 cataccacca tgcctggcta attttgtatt tttagtagag acagggtttg gcaatattgg  2761 ccaggctggt ctcgaactcc tgacctcagg tgatctgccc gcctcggcct cccaaagtgc  2821 tgggattata ggcgtgagcc actgcgcctg gccaggaatc gcttctttat tttcattttc  2881 atttatttat ttatttattt atttattttg agatggagtc tcgctctgtt gctcagtctg  2941 gagtgaagtg gcgtgctctc cgctcactgc tacctctgcc tcccaggttc aagcgattct  3001 cgtgcctcag cctcccaagt agctgggact acaggtgcgt gctaccacgc ccagctaatt  3061 tttgtattta gtagaggcgg ggtttcacca tgttggccag gctggtcttg aactcctggc  3121 ctcaagtgat ctgcctgcct cagcctccca aagtgctggg attacaggcg tgagccaccg  3181 ccctcggctg gaatcacttc tttaacatgc acagccccag acctcagtct cttggagatt  3241 ctaactgtgt gaattgggag agagaaaggg gaatctagat tttttttttt tttttttgag  3301 atgtggtctt gctatgttgc ctaggctgga gtgctgtaac tattcacagg tgcagttata  3361 gcacactacc acctcaaact cctgggctca agagatcctc ccacctctgc ctcccgagta  3421 gcttggactg caggtgcaca ccatcttacc cagctgaaat ctgctttttt tttttctcag  3481 tgcagtggca cagtcatggc tcactgcagc ctcgacctcc cagactcagg tgatcctccc  3541 aacttcagcc tcctgagtag cagggaccac aggcctgcac caccttgccc agctaatttt  3601 tgtatttttt gtagagacgg agtttcgcca gttgcccagg atggtcttga actcttgggc  3661 tcaaatgatc cgccgcccgc aatgggccca gctggaatct gcattttttt gttttttgtt  3721 ttgagatgaa gtctcactct gtcgcccagg ctggagtgca atggcgcaat cttggctcac  3781 tgcaacctcc gcctcctggg ttcaagccat tctcctgcct caggctccca agtagctggg  3841 attacaggca cgtgccatca cacttggctg atttttgtat ttttagtaga gacagggttt  3901 taccatattg gccaggctgg tctcgaactc ctgacctcaa gtgatcggcc cacctcggcc  3961 tcccaaagtg ctgggattac aggcatcagc cactgtgcct ggcctggtat ctgcattttt  4021 atgaacagcc caggagggtg taatgcagag tccttggcgt gcactttcag caacactgca  4081 gtaaggacta gaaatcgcac atcaaatgct ggcagagtgc ctggtgctta gtaggtgctt  4141 agtgagtgtt tgttgagtga ataaatgaac aggaatggat ggagaacagg aacccaaagg  4201 aatggatgag taaccttatt tccttggtcc ttgtctggaa actggggcaa ctggggctgg  4261 ggttcaggtg agtggccagc cagtcatctg gtctttgcct ccccctcatt tttgccaggc  4321 ctcacataga cggtcagcca ttggatcata ggaactgccc tggcctgact cacccaatat  4381 ggaggaggtg cctggggatg ccctgtgtga acactttgag gccaacatac ttacccagaa  4441 ccgctgtcaa aactgcttcc accctgagga ggcccatgga gcaagatacc aggtgggcca  4501 gttttccacg tggttggggt ggtttgtgat gggggcatgg gtgaaggact gggcctgtgg  4561 tgtccgctaa ctcgcagttg aacccagatg ctggacttcc tcctgtcgag agcctcggtt  4621 ttcccacatt gcagggaagt ggttgaacca tgtgaatgtt tcacaatctt cagtcacttt  4681 cctcctgctt atatgatacg attgttacca tagccttatc taatctgtta cttactttgt  4741 tattctttaa atcaacatct ttttcccctt ctattgaaac aaaacttcac atcatcaaca  4801 caagtagaaa actagaatta cttcctgtta agaagaagag gttaagaaga aaggtagagg  4861 ctgggcacgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg tgggtggatc  4921 acccgaggtc gggagtttga aaccagcctg gccaacatgg tgaaaattag ctgggcatgg  4981 tggtgcatgc ctgtaatccc agctacttgg gaggctgagg caggagaatc acttgaacct  5041 gggaggcgga gattgtggtg agccgagatc gcgccattgc actccagcct gggcaacaga  5101 atgaaactgt ctcaaaaaac aaaacaaaac aaaacaaaaa agagaagaaa ggtagaaaaa  5161 gaaaaaacaa aacagaaatg tcgttacacc ctaacttgag agtgttttct ttttcttttt  5221 cttttttttg agacagagtc tcactctgtc gcctgggcta gagtgcaatg gcaatggtgt  5281 gatctcagct cactgcaatc tctgcctcct aggttcaagc gatcctcccg cctcagcctc  5341 ccaagtattg ggattacagg tgcctgccac catgcccagc taatttttgt atttttagta  5401 gaaacggggt ttcgccatat tggccaggct ggtcttaaac tcctgacctc aggtgatcca  5461 cccgcctcag cctcccaaag tgttgggatt acaggcgtga gccaccgcgc ctggcctcga  5521 gagtgttttc tatggaaggc tctgagcttg catcctgctg tctctttgtc aaaaagggag  5581 attagcagat gttagagaga tgttaagaat acaccagcat catctagaga ttttctttct  5641 ctctctcttt tttttttttt tttttttttt tggagatagg gtcttgctct gtagcacagg  5701 ctggagtgca gtggtccaac ctatagtaca tggctcactg tagcctcgac ctcccaggct  5761 caaatgatct tcccaccttg gcctcctgag tagcagggac tacaggcaca tgccaccatg  5821 gccagctaat tttcttgtaa agatgggatc tcactatgtt gccagggctg gtctcaaatt  5881 cctgggctca ggtgatcctc ccacctcaac ctctgtaact gcagggatta caggtgtgag  5941 acactgcacc tggtctcaag attttcttct tcaagttatt gaaggagtga agaagaatcc  6001 ttttttttct ttcttttttt ttcatttgag acggagtctc tctctgtcgc caggctagag  6061 ttcagtggct caatctcagc tcactgcaac ctccgtctcc tgggttcaag caattctcct  6121 gcctcagcct cctgagtacc tgggattaca ggtgcccacc accatgccca gctaattttt  6181 gtatctttag tagagacagg gtttcaccat gttggtcagt ctggtctcga actcctgacc  6241 ttgtgatctg tctgcctcgg cttcccaaag tgctgggatt acaggtgtga gccaccgcgc  6301 ctggccgaga ttttcttctt caagttattg aaggagtgaa gaagagtcct tttctgactt  6361 tgtgattgat gtagtctgct gccaagcccc catgcatgta aacacagagc acctgataca  6421 cacgcaatga gaaacctggg actcacgaac ctccgagggc ccttccaacc ttgaccacca  6481 tggcttcgtc attcccattg gggtctgaag gtcctctttt tttttttttt tttttgagac  6541 agagtctcgt tctgttgccc aggctggagt acagtggtgc gatctgggct cactgcaagc  6601 tcggcctccc aggtttatgc cattctcctg cctcagcctc atgagtagct gggacaacag  6661 gcacccggca ccacgcccag ctaatttttt gtctttttag tagagacagg gtttcaccat  6721 gttagccagg atggcctcga tcttcctgac ctcgttattc gcccacctcg acctcccaaa  6781 gtgctgggat tacaggcatg agccaccgcg cccagcttct accagtcttg atacctccaa  6841 taatagctct cttgtgctca cctgcaagtt caggttcagg gaacagatgc ctgggagtcc  6901 atctttcatg caaatgactt tcttccagtg gttgggaaga tggcaagaat ggaacaggag  6961 agccgtggat tcaggctcgt ctgagttcta gtctcaatcc caccatttcc cacccgagac  7021 cgtgggtcag ctcacaaatt catacgtact gaataggtgc ttaaaatgtg ccaggcatta  7081 tgctagatga tggggaaatc atgataaatc agaaaggcac agccaggcac agtgactcac  7141 tcctgtaatc ccagcacttt gggaggccaa ggtgggtgga tcacttggag tttgagacca  7201 tcctggcaac atggcaaaac cccatctcta caaaaaattt aaaaaattag ctgggcgtag  7261 tgggatgcgg ctatagtctc agttactcag gaggctgagg tgggagaatc acctgagact  7321 gggaggcggg ggcttcagtg agccgtgatc gcattactgt atttcagcct gggtgacaga  7381 gttggaccct gactcagaac agaacagaac agaacagaac agaacagaac agaacagaac  7441 agaacagaac agtacagaaa acagggagaa ggaggggaag ggggagggga agggggaggg  7501 ggagagagag gaggagagga ggagagaggg acacatccct ggcttgtctt catggggctt  7561 atattctagc aagagaaatg cacatgatta tttaatcttg gttgtgataa atgtataaag  7621 gaacagtaag tggcatgaag gtaaaggata gggcattagg gaaagtttct ccaaaaaaaa  7681 aaaaatgaca tttcagctgc ttagtaaagg ctgtgcaggc attagcatta gtgaaattgc  7741 aggaagagga gaggaaggaa ggagaatgtg caaaggccag cctggcacgg cagctcacgc  7801 ctgtaatccc agcactttgg gaggaagtgc ttggattgag gcaccgaagc aggaagatca  7861 cttgaactca ggagtttgag accagcctgg gcagcacagt gagaccccat ttctaccaaa  7921 aaaaaaaaaa aaaaaattag ccaggcagga tggtgcacac ctgtagtccc agctagtcag  7981 aaggctgatg tgggaggatt actggatccc aggagttcaa ggttgcagtg agccatgagc  8041 atgccaatgc actccagcct gggcaacaga atgagacctt gtctcaaaaa caaaacaaac  8101 aaacaggtca ggtgcagtgg ttcatgcctg taatctcagc actttacgag gccgagacgg  8161 gtggatcacc tgaggtcagg agttcaagac caccctggcc aacatggtga aaccccatct  8221 ctattaaaaa tacacaaatt agctacatgt ggtggtgggt gcctgtaatc ccaggtactt  8281 aggaggctga ggcaggagaa tctcttgaac ccaggaggca gaggttgcag tgagccaaga  8341 ttgcaccact gtactccagc ctgggcaaca gagcgagaat cctctcaaaa caaaacaaac  8401 aaacaaagaa tatgcaaagg ccctgaggca gaaaggaggc tgcacatcgg gctggagagg  8461 acaggcaaga ggggggcaca gaggagctat aggacaagga tggagaatgg ggggaggcct  8521 ggtctcactg gccttgtgcg gctttgtgga catgttgagg acttaggatt ctgaggtttt  8581 tttctgtttt gtttttgttt ttttttgaga tggagtctcg ctctgtcgca caggctggag  8641 tgcagaggcg tgatctcggc tcactgcaac ctctgcctcc caggttcaag cgattctcct  8701 gcctcagcct cccaggtagc tgagactaca ggcatgtact accaaaccca gttaattttt  8761 gtatttttag tagagatggg gtttcaccat gccgctcagg ctggtcttga actcctggcc  8821 tcaagcaatc tgccctcctt ggcctcccaa agtgctgaga ttacaagtgt gagccacctc  8881 gcccggccaa gccacggaag atttcaaata agggagtgac gtgctctgat ttgcattttt  8941 cacagtcact ctgattgctg ggcagagaga atggagggca gggtggtgag agtgaatcag  9001 gtgacccgcc aggaaaaggt gcacgtactc atcggtgcca gagatgattg gggctttgag  9061 atggaggcaa atggacacat ttccgaacta attgagcagg cacgtctaca ggatttgggg  9121 gtgagggagg ggagaaaccc atggctgact cctgtaattt cttcaggcag ggtacttggg  9181 ttgggaggtc tgtttggagt tgtctggggc atggtgtggg gtgtcggcag gatacagtgg  9241 agatgagggg gaagttagtg aattggtggg gctggagctc agagccagac catcacagga  9301 gatggaggcc tgcgagtctt caggatctgt cactgaccaa agtcttgctc acggatgagc  9361 ctatcatctg tggaagaaag tgtggaatga gatgagaaca ggcctgggtg gaggccaggg  9421 aatcagcaga gacagccaag aaggccagag gctaggaggc aaaccccaca gtgtgcccct  9481 cctccccagg agccaagacc agagatggtt tcaagagagg gggccaggca caatggctcc  9541 cgcctgtgat cacagcactt taggaggctg aggctaaagg atggcttgaa accaggagtt  9601 taagaccagc ctagttaaca aagtgagatc ccatctctac aaaacaaaaa atgaactggg  9661 tgtagtggtg catgcctgca gtcccagcta cttgggaggc tgaggcagga ggattgtttg  9721 agcccaggag attgaggctg cagtgcactg tgatcatgcc actgccacag caagactatc  9781 ttaaaaaaaa aaaaaaaaga tcagagaggg gcacgacatc aaatcctcca ctttcttgag  9841 cttccagttg ctctgatgat gatcaaggct gtgaaactct cctttggcaa atgcatgagg  9901 ggtgactgtt gtgtctccga gccaggccct gggacccaac tctgggcagg tagcagctcc  9961 ctgtgtatac cagatgtgat agtaaaaaac tgacactggg ccgggcgcgg tggctcacgc 10021 ctgtaatccc agcactttgg gaggccgagg cgggtggatc acttgaggtc aggagtttga 10081 gaccagcctg actagcatgg tgaaatcctg actctactaa aaatacaaaa atacaaaaat 10141 taacagggtg tggtggcgga tgcctgtaat cccagctact cgggaggctg aggcaggaga 10201 atttcttgaa tccgggaggc ggaggttgca gtgagccgag atctggccac cgcactccag 10261 cctgggcgac aagagcgaaa aactccatct caaaaaaaac aaaaaaacct cctgggcccc 10321 agaagatggc aactgcctct tccagcctct tccacctgcc tgcctgtgca ctcctctgcc 10381 actctggacc tattccatgg tgccacgtgg tcaggcattg aaggaatggg tgggtttttt 10441 ttccatcacc ctcagatgct gctgctgggg ttggggcggg tcttccctgg ctgactctgt 10501 ctgcctcacc cactctctcc ccatctctct gtcaccacag gtctccaggg accaaattta 10561 gcccattttt cctccaagga ttctggaccc ttggccatat ttgcctctag ctttaggtca 10621 acagatttct aacatggagt caaaaaatct gtatgtttaa aaaaaaaaaa ttggctggga 10681 gtggtggctc acgtctgtaa tcccagcact ttgggaggcc gaggcaggtg gatcacctga 10741 ggtcaggagt tcgagaccac cctggccaac atggtgaaac cccgtctcta ctaaaaatac 10801 aaaaattagc tgggtatggt ggcggacccc tgtagtccca gctactcagg aggctgaggc 10861 aggacaattg cttgaacccg ggaggcagag gttgcagtga gctgagatcg cgccattgca 10921 ctccagcctg ggtgacagag tgagactctg tctcaaaaaa aagaaaaaaa aaaaaaaggc 10981 cgggcgtggt ggctcacggc tgtaatccca gcactttggg aggccgaggc gggcggatca 11041 cgagatcagg agatcgagac catcctggct aacacggtga aaccctgtct ctactaaaaa 11101 tacaaaaaat tagctgggca tggtggcggg cgtccatagt cccagctact cgggaggctg 11161 aggcaggaga atggcatgaa cccgggaggc ggagcttgca gtgagccaag atcacgccac 11221 tgcactctag cctgagcgac agagtgagac tccgtctcac aaaaaaaaaa aaaaaaaaaa 11281 attgaggcca ggcacagtgg ctcatgcctg tgatcccagc actttggccg aggcaggcag 11341 atcacctgcc atcaggagtt cgagaccagt ctcgccaaca tggcaaaccc ctgtctctac 11401 taaaaataga aaaattagcc gggcatggtg tcgggcacct gtaatcacag ctactggggt 11461 ggctgaggca gaagaattgc ttgaacccag gaggcgaagg ttgcagtgag ccgagactgc 11521 accattgcac tctaacctgg gctataagag cgagactctg tctcaaaaaa aaagcccttt 11581 acaaatatta actcgtttaa ttctcagaac acccctagga ggtgggtcct gctatcctgc 11641 cggttttgta gatgaggtaa ctgaggcaca gagaggataa gtcacgtggc ccaggtcttg 11701 gtcgcttctc agcctccatt tccgagagga gaaaacaatg ctccgaaagg ggaagtcatc 11761 ggcctgaggt caccagccgg gaaccggagg agccaggatg gggcccgagg tccatctgag 11821 gccagagcca gtgctgaccc gccagacagg aaatcagagc tggggactga ccgtggggcc 11881 cactcaagtg ggtggtgtgg ggtggtgacg ggggctgggg tgaaagccag gatgaggtgt 11941 cacattaggc tagggttcct gctgggcctg gcggggcaga gacccctggt tgatgcctgg 12001 caagtctctc ctcatttctg ctgtgctgtc ccctgggtgg ccaaggcgcc aggcccggct 12061 gtggatctga cacctcctgc tgccgagctc tgatcagaat ctggctgcag ggcagggggt 12121 gaaactgaat cccaccaggc ctcccctggc ctggatgtca cggcagacat cccaacccca 12181 cttcttggca ctgcctgacc ccagcagtgg ccttcttgga acctggagag cctgtgccca 12241 ccctgtggtg ccgaccaggc tgctgccttg gccctgggct ctgggctcca gggtccccag 12301 ggatcccagg cccaggctct tgcccctccc ggctctcagg tgagctgctg ggatcgggtt 12361 cctgcggttt catgtctttc attgttcttg gctggggccc ggcttatgaa actgtaatga 12421 ggggcccctg ctcccgaagc cggcccctct aaggtttcca ctgcctcggc ggctgctgcc 12481 accacagccc ggagtcgggg cctgggaggg cagcagtgtg ggggcctgag ccggagcccc 12541 ccggggacga gggtgctgac agtcgacagc caccaccacc accagagccc gcagcccagg 12601 taatccgaga ggaggcgggg cgcagggtgc catggccgct gtctcccacc accaggggag 12661 ggaactgccg ctctccagag gtggggagga attggggggg gccctggagg tgagcagccg 12721 ttcccccctg gtgagcccag caccagacca gccttcacag gtgtggcctt gccaaaggtg 12781 gagggagaga ggagtgggca gctggctcta gcccccgccc ttttcctggg gccttgaccc 12841 tccagccctg gatcccctgc ctctccttta gtggggcaaa tctcttctgt cctccaagac 12901 cttgctttcc catctcctct accatcaaac tgcctcttcc tccctcagac ctctcccttc 12961 tctcagccag cctaatcctt cctcctcgcc cttgtctttt ggccgcaaaa gaccctggtg 13021 gatccttcta tccacctcgt tctggggcgc acgcacatac atgcatgtat acatgaagtt 13081 gcactcatgc aaacgtacag atcggtgtac ccgcgggacc tgcgtagaca cgcatgcgca 13141 agagctcgct ccacctatgt gcacacatgt gcccccaata ccaggccttt atccacacac 13201 atacctgctc caaggcccat atgtgtacac tcacgtgtgc aggcacacac caggtacctc 13261 agccagccct cggcttgagt cccaaggggt gcttctagcc tgatgggcag ctccttgaga 13321 agtgcaggat cccccgagga gatgcctgga gactcccacg ccaccgggag gggctgtgca 13381 gggggagggg agcccccacg tgggcgctga gctgtctcct ctctccaacc ctggcccagg 13441 agctcaggag cccttcaggt gctgaggtgc cctactgcga cctgcctcga tgtccacctg 13501 cccctgagga cccactcagc gcctcaacct ccggctgcca gtctgtggtg gacccaggcc 13561 tcaggccagg gcccaagagg tgggtagagt cccagggccc aggaagggct tcatggggtg 13621 gaatgccctc acccttccca tttgcactcc ttccccaagg cagcacctgt ctctaatggc 13681 tgctggcatg ggtcacgtgg tcagtcctct aaacctaggc acaggtgggt ggtgggcatg 13741 ctccttgggc ccacaggaag aactcagatc acaccaccct gtttgcactt cagtggctga 13801 gcctcccctc cccagtcctg gctgtctctc ccaggggccc tgcccacccc ataacctccc 13861 aagaccgagc tcagctttgc cccagggtgt gtggctgctg tacactcacc ttgcagtggg 13921 catggccaca gcctactcac atttcctggt tccctttgca cagctttaaa agattaaaca 13981 gtccctgcac ccaggggcac ctgctgtcac ccacctacgt gggtgtgcac tgctccaggc 14041 tctggggttc cttccaccct caggcctgag tggcagtccc cctttaaggt catggtacct 14101 tgggaggcca tggtctgaga gtctagaaac ctgggttcca gcttcagatc catccctgat 14161 gggtcttgag caagttactc tgtctttctg tgtctcagtt tccctctctg taaaataaga 14221 gggattgaat taaatcagca ttgtgctggg atcattcatg tgctcctcac aggtaggcat 14281 attaaaacaa acaaacaaac aaaaaaacag cctgggtgca gtggctcatg cctgtaattc 14341 cagaactttg ggaggccaag gtgggcggat cacttgaggt caggaggtcg agaccagcct 14401 gaccaacatg gcgaaaccct gtctctacta actatacaaa aattagccag gcatggtggc 14461 aggtgcctgt aatcccagct gctcgggagg ctgaggcagg agaaccactt gaacccggga 14521 ggcagaggtt gcagtgagtt gagatcgtgc cattacactc cagcctgggt gacacagcga 14581 ggctccgtct caaaaaaaaa aaaaacaaca aaaaaaaaaa acaaaaaaaa acccacaaaa 14641 aaacgaaaaa aaaaacaaag acagctttgt tatcaagtat gtttcagaaa gtctgggata 14701 aatgaagttg aatagctttc ctgcaggact tgtcagagcc tttagcttgc ctgcgtgcat 14761 cgtggctttt gggtaacgga agtagagaag tatgtcattt gactacagag ctctttttta 14821 tggccatcac ttattatcat cgtgtaggcc agtctgtggg tcactctttg gggatactgc 14881 cagcgctaag ccttcttgag cctgtgactt cttttaaagc agagccttct ctgcagctcc 14941 ctccctcagc atctgggcta gtgaacccgt caatgcctgt ggagccatgc tgcctctcac 15001 atcctcgtta gccaagcatg agtctgtctt cttagactta ctgaacttgg ggtcagtaga 15061 ctaagactaa gacttaaagt tggggctggg gcaatagttt tggttcataa cacagctctg 15121 ccctttccta tctcggtgac cttggccagt ctcttgacct ctctgagcct cagtgtcttc 15181 ctctgtgaaa tgggaattat tattattatt attattttga gatggcatct tgctctatca 15241 cccaagctgg agtgcaatga cacgatgttg gctcactgca acctcagcct cccgagtagc 15301 tgggattcca ggcatacacc accacacccg actaattttt gtatttttat ttatttattt 15361 ttgagataga gtctcgtgct gtcacccagg ctggagcgca atggcacgat cttggctcac 15421 tgcaacctcc acctcctggc ttcaagcgat tatcttgcct cagcctcctg agtagctggg 15481 attacaggtg tgtgccacca ccatgcccat ctaatttttt tatttttagt agagacgggg 15541 tttcaccatg ttggacaggc tagtctcgga ctactgacct caggtgatcc acccaccttg 15601 acctcccaaa gtgctaggat ttcaggtgtg agccactgcg cccggcctaa aatgggaatt 15661 attatactta ctttaaaggg atgctgttgc tgggcgcagt ggctcacgcc tgtaatccca 15721 gcactttggg agtccgagac gggcggatca cgaggtcagg agatcgagac catcctggct 15781 aacacggtga aaccccatct ctactaaaaa atacaaaaaa ttagccaggc gtggtggcgg 15841 gcgcctgtag tcccagctac tggggaggct gaggcaggag aatggcatga acctgggagg 15901 cagagattgc agtgagccga gatggtgcca ctgcactcca gcctgggtga cagagcgaga 15961 ctctgtctca aaataaataa ataaataaat aaataaataa ataaataaat aataaaatta 16021 caaaaaaaaa agggatgctg ttttagctca atgaggcaat ccatataaaa agtctgacac 16081 agaggcagct ctcaccattg gctccctttc ccacaccagc gtgtgggccc caggctccct 16141 gtgtgagtga gtgcatatgc ctgggtgggg tgggggatgc tcctaactcc ccattacttt 16201 ttgggtctgt ctcctctccc aggggcccat ccccctcagc agggctccca gaagagggtc 16261 ccacagctgc ccccaggagc aggagccggg agcttgaggc agtaccctat ctggagggcc 16321 tgaccacttc cttgtgtggc agctgcaacg aggaccccgg ctctgacccc acctccagcc 16381 ctgactccgc cacccctgat gataccagca actcgtcctc tgtggtgagc caggagtggg 16441 agtttggggg acaagagtgg ctcacacctc catctgcagc cctgggtccc acctaaacct 16501 ccaggccagg gctgagcctc acaccaggga atccgacgag gtcctctgga ccattagctg 16561 gcagctcggg ccaccccggc gaacccctgg agagtgggga tttctgcaca ggctggccca 16621 gggcagctgg ggtctggctg tgaaaagaca gggaaaggag tttcagccga caggagctct 16681 gggtgaatca ccagcaggct cgggctgcca catgctctca gatcccagag tgttgggttt 16741 ggtgtctagc gcaagagtgg cacagggccc cagggccctg ccctcgacac acagtgctga 16801 gtcccatggc cagccctgga atagatttcc aagagacaga ggaaagggag caggctgcgg 16861 gggtcattta accacgaaaa gagaagagcc agcagtcttt cctccagcat ttgcattttg 16921 aggggctgcc gcagagcaga agagacaggc ttgtcccagg agacccccca aaaggaaaat 16981 gacagggggt ggtgataaga ctcagaataa aacaacccag cctcacacgc ttcatggcca 17041 gctccatgct aagggcttgg tgggtgtggg ctcaggggag actcaccaca gcctcagaag 17101 tggagatttc agtcgcccca tatggggctg aggctcagcg gggggagcaa cttagtggag 17161 gccacacatc tgggaagtag tggggctagg atttgaaccc acttttctct ggcccctggg 17221 gctacctcac acagtcccac atgcggaact ctgggactct gggcaaagct cttggcttca 17281 atggatgtac atgcctccta ggtccgttga agatgagcga cttggcactt agcacctgct 17341 agagcccagc acagtgccag gcaaacagca catgctttta atttaattga ttgattgaag 17401 actgggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccaag gtgggcggat 17461 cacctgaagt caggagatcg agaccagcct ggccaacatg gtgaaactct gtctctacta 17521 aaaatacaaa aattagcagg gtgtggtggt gggcacctgt aatcccagct acttgggagg 17581 ctgagacagg agaatcgctt gaacccggga ggttgcagtg agcttagatt gcaccattgc 17641 actccagcct gggcaacaag agcaaaactc cgtcttaaat agagaaaaaa aaaaaagttg 17701 attgattgag acagggtctt gctccattgc ccagactgga atgcaatgat gtgaacatgg 17761 ctcactacag ccttgacttc ctgggctcaa gtgatccccc cacctcagcc tcctcagtag 17821 ctgggactat aggcatgcac aaccatgcct agttattatt atttttttta attttgtaga 17881 gacagggtct cactgtgttg cccagcctgg aagtgctttt tactgaggcc atggagcgga 17941 gtctacacca cagaaggtgt ggcaccactc actgtcacct cttggggaca gaacttgaca 18001 gtttaggaag tgctttttat tttttattta attttattta tttttgagat ggagtcttgc 18061 tctgtcacct gggctggagt gcagtgccac aatctcagct cactgcaacc tctgtctccc 18121 aggttcaagc gattcgcctg cctcagcctc tcgagtatct gggattacag gcgcccacca 18181 ctatgcctgg ctagtttttg tatttttaat agagacaggg tttcaccatg ttggccaggc 18241 tggtttcgaa ctcctgccct caggtgatcc acctgcctca gcctcacaaa gtgttgggat 18301 tacaggcgtg agccactgcg ccctgcaggg aagtgctttg tttttttttg ttttgttttt 18361 ctttttgttt tttgagacag agtctcactc tgtcacccag gctggagctc agtggcgcga 18421 tctccactca atgcaagctc cacctcccag gttcacacca ttctcctgcc tcagcttccc 18481 aagtagctgg gactacaggt gcccgccacc acgcccagct aattttttgt attttttagt 18541 agagatgggg tttcaccatg tttcccagga tggtctcgat ctcctgacct cgtgatccac 18601 ccacctcgtc ctcccaaagt gctgggattg caggcgtgag ccacagcgcc tggccaggga 18661 agtgcttttt aatgccaatt cccttccctt ccttctgccc ctctcatttg gagagtatat 18721 gtcctgcagc cttttttctc ccgcaaacat actttctcct ccccttctct ggcaggactg 18781 ggacactgtt gagaggcagg aggaggaggc ccccagctgg gacgagctcg cagtgatgat 18841 cccgaggagg cctcgggagg ggccgagagc tgacagctcc caaagggctc cgtctctcct 18901 caccaggtcc cctgtgggag gagatgctgc aggccagaaa aaggagggtg agtccttctg 18961 ccaggttggt tcccatggtg atggcctggg gccccccaga tagccatctc actggccatt 19021 tgggactctg ggcacggctt actttggtgg cctgagtgtt aataatagta acagtttgca 19081 tgtcatgatg gagcagccac aatgagttat gctacccact ttaattatta ttattattat 19141 ttgggatgga gtcttgctct gttgcccagg ctagagtgca gtggtgtgat ctcggctcac 19201 tgcaaccttt gcctccccag ttcaagcgat tctcctgccc cagcctccca agtagctaag 19261 attacaggct cccgccacca tgcccagcta atttttgtct ttttagtaga catggggttt 19321 caccatgtta gcccagctgg tctcaaactc ccaaccttca gtgatctgcc catcttggcc 19381 tcctaaattg ccgggattac aggcgtgatt acaggcacgc ctagcctgtt attattatta 19441 ttattactat tattattttg agataagagt ctcacactgt tgcccagact ggagtgcagt 19501 ggtgccctct tggctcactg caacctccgc ctcctgggtt caagagattc tcctgcctca 19561 gcctcctaag tacctgggat tacaggcacc cgccaccaca cgtggctaat ttgtgtattt 19621 ttagtagaga cagggtttca ccatgttggc cgggcttgtc tcaaattcct ggctggggat 19681 tacaggagtg agccactatg cctggcctta gccaaggagt ttggacttct ctaaatagta 19741 gggagccacc gaaggttttt gaggaggaaa gtcatgtaat taaacctgtg cctcaggaag 19801 ttccctagat caaagatgca aaggatgaat tggagcaggg aggggttgaa ggatgagaaa 19861 ccagttaaga gactgttgca ggcactgtag caataactgg ttcaggcatg aatcactggc 19921 ggatgcaaaa tccctagggt gataatttgt cagcaaacag gatagtcatg gtttcaaagt 19981 attgtgtccg gaattggtgg gttcttggtc tcactgactt caagaatgaa gcggcagacc 20041 ctcgcgatat tacagttctt aaaggcggcg tgtctggagt ttgttccttc tgatgttcgg 20101 atgtgtttgg agtttcttcc ttctggtggg ttcgcggtct cgctggctca ggagtgaagc 20161 tgcagacctt tgtggtgagt gttacggctc ttaaggagac gcgtccgcag ttgttctttc 20221 ctccctgtgg gttcatggtc tggatggctt caggagtgaa gctgcagacc ttcgtggtga 20281 gcgttacagc tcataaaggc agtgtggacc caaagagtga gcagcagcaa gatttattgc 20341 aaagagcgaa agaacaaagc ttccacagca tggaagagga cccgagcggg ttgccagagc 20401 tggctggggc agcctgcttt tattctcttg tctggcccca cccacatcct gctgattggt 20461 ccattttaca gagagccgag tggtctgttt tgacagggcg ctgattggtg catttacaat 20521 ccctgagctt gacacaaagg ttctccacat ccccactaga ttagctagat acagtgtcca 20581 cacaaaggtt ctccaagtcc ccaacagagt agctagatac agagtgtgga ttggtgcatt 20641 cacaaaccct gagctagaca cagggtgctg attggtgtgt ttacaaacct tgagctagag 20701 acagagtgct gattggtgta tttacaatcc cttagctaga cataaaggtt ctccaagttc 20761 ccactacact caggagccca gctggcttca cccagtggat ctcgttctgg ggctgcaggt 20821 ggagctgcct gccagtccca tgccatgcgc ccacactcct cagcccttgg gtggttgatg 20881 ggactgggcg ctgtggagca ggggcggcgc tcatcgggga ggctcgggct gcacaggagc 20941 ccacggaggc ggggggaagc tcaggcatgg cgggctgcag gtcccgagcc ctgcccggtg 21001 ggaaggcagc taaggcccgg cgagaaatcc agcgcagcgc tggtgggcgg gcactgctgg 21061 gggacccagc acaccctccc cagccgctgg cccaggtgct aagcccctca ttgcccgggg 21121 ccggcagggc cagccggccg ctccgagtgc ggggcccacc aagcccacgc ccacccggaa 21181 ctccagctgg cccacaagcg ccgcgcgcag cctcggttcc cgctcgcgcc tctccctcca 21241 cacctccgtg caagctgagg gagccagctc cggcctcggc cagcccagga aggggctccc 21301 acagtgcagc ggtggcctga agggctcctc aagtgccgcc aaagtgggag cccaggcaga 21361 ggaggcgccg agagtgagcg agggctgtga gggccgccag catgctgtca cctctcagta 21421 tcacccctca gattctgcat cgattactga gagaaaggca cccttaggct ggggagagcg 21481 ggaagatacc actttcacca agaggctgct cagcatcccc agagtggggc aaaccaacat 21541 aatatgcccc ctgatatgat gcatggggtc aggggagggg atgctggggt gggcacagaa 21601 tcccttccct tctaaatcgt cctgctgaaa atgcattgcc tacacctaac cccagtgaaa 21661 catcagacaa acccgaattg aaagacattc tgcaaaatga ctgggctcct cataggacaa 21721 aaagcggcta ggggactctt cttgattaaa agagactaac aggatgagga cgtggaatgc 21781 catgtgtgag cccattggga tctgggacag gaggacacag agctgtgaca ggcattactg 21841 ggacaactgg ggcttgtttt tttttttttt tttttttgag atggagtctt gctctgttcc 21901 ccaggctgga gtgcagtggc gcgatctcag ctcattgcaa cctccacctc ctgggttcaa 21961 gcgattctcc tgcctcagtc tcctgagtag ctgggactat aggtgcctgc caccacgccc 22021 agctgacttt ttgtatttct agtagagaca gggtttcacc atgttgagcc tgatgggatc 22081 cgggacacgc ctatagtccc agttactcgg gatgctgagg caggaggatc gcttgaactt 22141 gggaggtgga ggttgccgtg agctgagatc gccccactgc actcccgcct gggcaacaga 22201 ataagactcc atctcaaata aataaataaa taaataaata aataaataag ggccatggtt 22261 gtggggtgag gaggggacag agaaggagag aggtttagga ggcagacttg atggtacttt 22321 ggacaggagg atacacagtc acagctcctg gcctgggtgt ctgggtagat ggtgtgccct 22381 ttgctgagag caggtggctg gggagcggat gggcccagcg ctggctgtgc tgtgtgggat 22441 ttgcgagccc tgaggaagag gttttgaggc ttcagatgct cagggaagca ggggatggag 22501 atgtggcatc ttcaactgag gagcaatgtt cactcaggca ctcagcagac gtttacttac 22561 tgcccacaag tcaatcatgg ctgaatagat gaggcagcaa tgagaacagc agcagcatta 22621 cagcagtgac ctgttttttt gatgttccag gccttgtgct aaataaatgt cttgcacaga 22681 atcactctgg gctccccgat ccctcactcc tggtctgcct ccttcctcac gggccactcc 22741 acctcgctct cctttgctga ggccgcctcc tctgcttcac ttttaaatat ctgatgcccc 22801 acatcccagt cctgggcccc ttctgtcttc tccctgcaca cttagctgct tggctttcgg 22861 tactgtctgg gaaaaaccat gactccggag tccacatctc tggccttgat ttctcccctg 22921 aacctgccaa tttatacaac ccagccctct actgcgttaa tcacacctca ggccccacac 22981 tgcactcact gtttcactca tccccccccg cccttttttt tttttttttt tttttttttg 23041 agacagagtt tcactcttgt tgcccaggct ggagtacaat ggcgcagtct cggctcactg 23101 caacctccac ctcccaggtt gaagccattc tcctgcctca ggctcccaag tagctgggat 23161 tacaggcatg caccaccacg cccggctaat tttgtatttt tagtagagac ggggtttctc 23221 catgttggtc aggctggtct cgaactcccg acctcaggtg atccgctgat ccgcctgcct 23281 cggcttccca aagtgctggg attacaggcg tgagtgaccg tgcccggccc actgctacaa 23341 tactattaac taagctacag acgtgatggg attcaccagt ttttctacta atatcctttt 23401 tctgttccag gatccattcc aggatcccac attgccttta gtccctctcc tcatctcctc 23461 cgtctcctcc aatctgtgac aggtttccca tctcttccag tttcccctga aggctggggg 23521 cacagcgatc tgctcacctt tgactttaaa aaaagtctcc ctggatgaac aatgacattg 23581 gccccagagt gcccaggctt gggggctact gcaaccatcc aggagagaaa tagtggtggc 23641 ttggagtagg aagtgggtgt agatgagaga aacaggtgaa tatggaatgt atttatttta 23701 tttttcgtag agatgggggc tcactatgtt gcccaggctg gtctccaact cctgggctca 23761 agcaatcctc ctgcctcagc ctcccgaaat gttggaatta caggtgtgag ccactaccag 23821 gcatgaaacg tattttagaa tgccatggga catcagccac cagcaatttt ttttgttttt 23881 tgttttctga gacagagtct cgctctgtca cccaggctgg agtgcagtgg ccagatctca 23941 gctcactgca acctccacct cccgggttca agcaattctc cagcctctgc ctcccgagta 24001 gctgggatta caggcatgca ctactgcatc cggctaattt tttttttttt tttttgtatt 24061 tttagtagag atggggtttc accgtgttag cagggctggt atcgatctcc tgaccttgtg 24121 atccgcccgc ctcggcctcc caaagtgctg ggattacagg catcagccac tgctcccggc 24181 tgcatccagc taatttttgt atttttagta gagactggtt tcaccatgtt ggccaggctg 24241 gtctcgaact cctgacctca gatgatccac ccgccttggc ctcccaaagt gttagcatta 24301 caggcgtgag ccaccgtgcc tggcaacctt gcaaattttg aattccctgc taggtgctgg 24361 gaactcagac tttcaccaac accagcccag agaggctgga cgaggcagtg gctgcaaagg 24421 gagaggacag gggatcttaa gaaggcgtga agggagggga tctgcatgaa ggcaactgtg 24481 gctacttttt tgtttcgttt tttgttttaa gacaatgtct tgctctgttg cccatgctgg 24541 agggcaatgg cacattcttg gctcactgca acctccacct cctgggctca ggcactcctc 24601 cggcctcagc ctcctaggta gctgggacta caggcacgta ccaccaggcc ctgctaagtt 24661 ttaaaaaact tgtagtagag acagggtctc gccatgttgc ctaggctggt ctggaactcc 24721 tgagctcgag tgatcctccc accttggcct ctcaaagtgc tgggattaca ggtgtaagcc 24781 accacaccca tagttgtggc tcctttaaga tgaggccatg atacccttta ctcttcacct 24841 aaagcagtag ccaagggaca tgtacatagg ggtgctcaac acctgcttgg tgaccgaggg 24901 attgagcggg gtggagggtg acacaccaag gtcatggcaa ctctgtcatg aggctaggag 24961 ttgcaaagag ggtcactact gaggacagtt acattaatcc tttaggccag tgcttctgaa 25021 actataaggt gtacaaatca ccagacagtt ttgttaaatg cagatccaga agcagtgcat 25081 ctgggctggg acctgagatt ctgcatttct ggcaaactcc cagctaccag tttataaaag 25141 gttgtccatc cctgcacctt tcctatcctc atggcagccc taggagaagc ctcagggtag 25201 gaacatttgg atacaaaaaa acaggggctt tctagagctg tcgcacagga aacaggctca 25261 ttagaacctg tctctactaa aaacacaaaa atgagctggg catagtggtg catgcctgta 25321 atcccaacta cttgggaggc tgaggcagga gaatcatttg aacccaggag gcttaggttg 25381 cggtgagccg agatcgcgtc attgcactct agcctgggtg acagaacgag actctgtctc 25441 aaaaaaaaaa aaaaaaaggt cgggcatggt ggctcacgcc tgtaatccca gcactttggg 25501 aggccgaggt gagcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt 25561 gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc atggtggcgc atgcctgtaa 25621 tcccagctac tcgggaggct gaggcaggag aatggcttga acctgggagg cggaggttgc 25681 catgagccga gatcacgcca ctgcactcca gcctgggcga cagagcgaga ctctgactca 25741 aaaacaaaac aaaacaagaa atggggggaa ttccttggat tctgattgaa ggaaatagaa 25801 ctgggaaggg aagactgtca ggtggctgct gttgggccca cctctccctc cctggggtca 25861 cacaggccat tgtcaacact tctctccaca aatttgcttc ttctctgtct tgtccgtgga 25921 tccccagacc ctgtggcctt ccagttcttg aacccatctc ttgagtgagt cagggtctca 25981 atttcaaatt cttgacctca gcttgagaga ggcatccaag cccttgtcta atcagccttg 26041 gtcagagagg tggagtcact tggtacagac agtgagacct gtaggaggag ggtgtggggt 26101 ttgccctaat cactggtcct aagggacaaa gaaaggtaga atatgagagc tgcctggacc 26161 tctcccctta ccttgagccc ctctcttctc tctccagaca ccggcggtgg gggccggagc 26221 gcaggacagc actgggcaag gctccgggga gaaagcgggt tgtccctgga gcggcaccgg 26281 tcaacactga cccaggcttc ctccatgaca ccacacagtg gacctcgaag caccacgtct 26341 caggcttctc ctgcccaaag ggacactgct caggctgcct ctacacgtga aatccccaga 26401 gcctcctctc cccatcgaat cacccaaagg gacacctcca gggcctcatc cacccaacag 26461 gaaatctcca gggcctcatc cacccaacag gaaacctcca gggcctcatc cacccaagag 26521 gacaccccta gggcctcatc cacccaagag gacaccccca gggcctcatc tacacagtgg 26581 aacaccccca gagcttcctc tccctcacga agcacccaac tggataaccc cagaacctct 26641 tctacccagc aggacaaccc ccaaacttct tttcctactt gtactcccca gcgggaaaac 26701 cccaggacac cctgtgtcca gcaggacgat cccagagcct cctctcccaa cagaaccact 26761 caacgagaga attccagaac atcctgtgcc cagcgggaca atcccaaagc ctccagaacc 26821 tcctctccca atagagccac acgagacaac cccagaacat cctgcgccca gcgggacaat 26881 cccagagcct cctctcccag tagagctaca cgagacaacc ccacaacatc ctgtgcccag 26941 cgggacaatc ccagagcctc cagaacctcc tctcccaata gagccacacg agacaacccc 27001 agaacatcct gtgcccagcg ggacaatccc agagcctcct ctcccagtag agctacacga 27061 gacaacccca caacatcctg tgcccagcgg gacaatccca gagcctccag aacctcctct 27121 cccaatagag ccacacgaga caaccccaga acatcctgcg cccagcggga caatcccaga 27181 gcctcctctc ccaatagagc tgcacgagac aaccccacaa catcctgtgc ccagcgggac 27241 aatcccagag cctccagaac ctcctctccc aatagagcca cacgagacaa ccccagaaca 27301 tcctgtgccc agcgggacaa tcccagagcc tcctctccca atagagctac acgagacaac 27361 cccacaacat cctgtgccca gcgggacaat cccagagcct ccagaacctc ctctcccaat 27421 agagccacac gagataaccc cagaacatcc tgtgcccagc gggacaatcc cagagcctcc 27481 tctcccaaca gaaccaccca acaagacagc cccagaacat cctgtgcccg acgggacgat 27541 cccagagcct cctctcctaa cagaaccatc caacaagaga accccagaac atcctgtgcc 27601 ctacgggaca atcccagagc ctcctctccc agcagaacca tccaacaaga gaaccccaga 27661 acatcctgtg cccaacggga cgatcccaga gcctcctctc ctaacagaac cacccaacaa 27721 gagaacccca gaacatcctg tgcccgacgg gacaatccca gagcctcctc tcgcaacaga 27781 accatccagc gagacaaccc cagaacatcc tgtgcccagc gggacaatcc cagagcctcc 27841 tctcctaaca gaaccatcca acaagagaac ctcagaacat cctgtacccg acaggacaat 27901 cccaggacct cctctcccaa tagagccaca cgagacaacc ccagaacatc ctgtgcccag 27961 cgggacaatc tcagagcctc ctctcccatc agagccaccc aacaggacaa ccccagaact 28021 tgtattcaac agaacatccc cagatcatct tctacccaac aagacaaccc taaaacctct 28081 tgtaccaaac gagataacct cagacccact tgtacacagc gggaccgcac acagtccttt 28141 tcctttcaac gagacaaccc tggaacctcc tcatctcaat gctgcaccca aaaggagaat 28201 ctgagaccat catctcccca ccgctccact caatggaaca atcccaggaa ttcatctccc 28261 catcgtacta acaaagacat cccctgggcc tcgtttcccc tccggccaac tcagagtgat 28321 ggtccccgaa cctcttcccc atctcgctcc aagcaaagcg aggttccctg ggcatccatc 28381 gccctccggc caacccaagg tgacaggcct cagacatcct ctcccagcag gccagcccag 28441 catgacccac cccagtcctc ctttggcccc acccagtaca acttgccatc ccgggccacc 28501 tcttcctccc ataacccagg ccaccagagc acctcccgaa cttcctcacc tgtgtacccc 28561 gctgcctatg gggctcccct gacctctcct gagccctccc agcctccatg tgctgtgtgc 28621 attgggcacc gggatgcccc tcgagcctct tcgccccctc gctatttgca gcacgacccc 28681 ttccccttct tcccagagcc ccgcgcccct gagagtgaac cgccccacca cgagcctccc 28741 tatataccac ctgctgtgtg cattggacac cgagatgccc cccgggcgtc ctcgcccccc 28801 cgccacaccc aatttgaccc cttccccttc ctcccagaca catcagatgc cgagcatcag 28861 tgtcagtccc cccaacacga gccccttcag ctccctgcac ctgtgtgtat tgggtaccga 28921 gatgcacccc gggcctcctc cccaccacgc caggccccag agccttccct cttattccag 28981 gacctcccca gggccagcac agagagcctt gtcccttcca tggactctct gcacgagtgc 29041 ccccacatcc ccacccctgt gtgcattggg caccgggatg caccctcctt ctcatcccca 29101 ccacgccagg ctcctgagcc atccctcttc ttccaggatc cccctggaac tagtatggag 29161 agcctggccc cctccactga ctctctgcat ggctccccag tgctgatccc ccaagtgtgc 29221 atcgggcacc gggatgcacc ccgagcctcc tccccacccc gccacccacc cagtgaccta 29281 gcgttcctgg caccctcacc ttcaccgggc agctctgggg gctcccgggg ctcagcgcct 29341 cccggggaga ccaggcacaa cttggagcgg gaggagtaca ctgtgctggc cgacctgccc 29401 ccacccagga ggctggccca gagacagcca gggccccagg cgcagtgcag cagcgggggc 29461 cgcacccaca gccctggccg tgcagaggtg gagcgcctct tcgggcaaga gcgcaggtga 29521 gcccgggggt ggggtcagcc aggtgggctg gggaggaggc tcggcagcag gacaggtgaa 29581 gggttagggt gccaaaagaa agtgttcaaa tccccctggc ttgccattta ccggctgtgt 29641 gaccttgggc aaatcgctcc atttctctgt ttctgcatat tgggagtttt ctgttttgtg 29701 tgtgtgtgtg gttaagtgat gtcatgcaca gcccagtggt taacagcaaa gactgcagtc 29761 aggagggctg agtccaaatc ctgggtcaaa gccacatgtc aactcgtatg acctgatata 29821 gtgagttaac ctacctgagc ctcagtttcc tcatctgtaa gggaggggaa catgagcaca 29881 ttcattcaaa taagggtgaa ctgtcttttt attttttatt ttttgttttt ttttttgagg 29941 tggagttttg ctcttgttgc ccaggccgga gcgcaatggt gcaatctcgg ctcactgcaa 30001 cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagtag ctgggattac 30061 aggcacgtgc caccacaccc ggctaatttt tttgtatttt tactagagac ggggtttcgc 30121 catattggcc aggctggtct cgaactcctg acctcaagtg atccacccgc ctcggcctcg 30181 caaagtgcta ggattacagg agtgagccac cgtgcccggc caaaatgaga gtgaactctc 30241 aaaccctttg atccagactc atgggttttt tttttttttc ttccgtgcat gagggagaag 30301 aagaaagtac ccatgatttt ttcctgcctt ggcaaagaaa actcatgggt ccctatgcat 30361 ttcagaaaac agttatgtca atttaaaatg tatggccagg gccgggcacg gtggctcatg 30421 cctgtaatcc cagcacttgg ggaggccgag gcgggcggat cacaaggtca ggagatcgac 30481 agcagcctgg ctaacacggt gaaaccccat ctctactaaa aatacaaaaa attagctggg 30541 catggtggcg ggcgcctgta gtcccagcaa ctcgggaggc tgaggcagga gaattgcttg 30601 aacctgggag gcggagcttg cagtgagccg agatcgtacc actgcactcc aacctgggtg 30661 acagagtgag actccatcta aaaataaaaa taaaataaaa atgtatggcc agagctacct 30721 attttaagaa agaaagctca cagaattatg gatttttagc agtcaaacat cctgggacac 30781 ctgaagtcca ggtgtctttt gagtctcctt ggtcagcagc actggccccc tggaagggga 30841 gcatttcctc ctgatcaggc tgaggtttct ctccccagaa gttccagccc tcgagttttc 30901 aagaatcaga gctagaattc cattagttag ggtcaagaga acaacagcaa caaaaagcag 30961 tctggaagtc tcaaaacttt ccatgtatat aattcaacga atttttagtt tatttaccaa 31021 gttgtccaac cattgccaca atctaacttt agaacatttt catcacccta aagggtatgg 31081 aatattttgt atctaaaatt cctctttgct gctccttggg aaagttttct cctggatttg 31141 aatctgcatg agaaacctta tcagtcttgg ctgggtgcag tggctccctc ctgtaatccc 31201 agcactggag cttgcagtga gccaagatca tgccactaca ctccagcctg ggtgacagag 31261 tgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaatta gccgggcata gtggcacacg 31321 cctgtagtcc cagctactca ggaggctgag gcagcagtat tgcctgaatt tgggaggtgg 31381 agtttgcagt gagctgagat tgcgtcattg cactccagcc tgggcaacaa gagtgaaact 31441 ccatctcaaa aaaagaaaaa aaagaaactt tatctcttgt tcttcaaatt tccttttcca 31501 gtaagcttga tcatttaata tccagatgac aaccgtgtgg tctccagcat tagtataatt 31561 ctttctttgg ccttaaaaac aaaaacccag agcagtttta ggtttacagc aaaattgagc 31621 agaaagtgca gtgttccatg cacagcctct cccactacca atatcctgta ctagataggt 31681 atgcttgttt ccagctcctg gcctcaaggg atcctccttt cttggcctct caaagtgctg 31741 gtgagccact gtactgggca gtagggtgat acatttgtta caatccatga acctacacta 31801 tgaaatcacc caaagtttag ggttcactct tggtgatgta cagcctatag gcttgaatga 31861 atgtatgaca agtatccacc attgtaacat catggagtag tttcaccctg aaagtcttca 31921 gtgtctttaa cttttttttt tgtttggaga tggagtctcg ctctgtcacc caggctggag 31981 tgcagtagtg caatcttggc tcactgcaac ctctgccttc tgggttcaag cagttctcct 32041 gcctcagcct cccgaggagc tgggactaca ggagcatgcc gccacatccg gctaattttt 32101 ttgtattttt agtagcgaca gggtttcacc ctgttgccca ggctagtctt gaactcctga 32161 gctcaggcaa tctacccacc tcggcctccc aaagtgctgg gattataggc gtgagccacc 32221 gtgcctggtc tgaccttttt tttttttgaa acagggtctt gctttgtcac ccagcagtag 32281 tgcagtggcg tgatcatggc tcactgcggc ctcaaactgc caggctcaag cgattctctc 32341 acctcagcct cctcagtagc tgggactaca ggcgtgtacc actataccca gctaattttt 32401 ctactttttg tagagatgga gtctcacttt gttgcccagg ttggtctcaa actcctggcc 32461 tcaagcaatg ctcccacctt ggcctcccaa agtgtctttg acctttttat gattactatt 32521 tcttgtctaa tgtcaatttt cctaactttg tcttaactaa taactcagca gggacattaa 32581 ggtctttaag ccaaagttaa ttaattttct ttcctttttt ccaggataat ttcagagaga 32641 taaggtgttt atattaataa tagaaatgag aaatatgttt acacttttat taaccatttg 32701 tttttacacg atcactccta tacatttaat tctactctct ttgaaatagc ttatttacct 32761 tttagggaag ttttcataat tttactgaat aattaaaatt tttcctctta tctggcacct 32821 tttccaagta gaaaaccatt catcctctga atatggaaaa ttttaaaact gtgcagtgtg 32881 tgtgtaaggg acagactgga gcttatgagc gggtggctgt aggagtgtgc ttttattttc 32941 tcctatttcc tcatcgatat gtatttattg agcatctact ctgtccaagc attgtcccga 33001 gtctggaaaa tttttcttaa agggttgtca catcaaagca ttgggagttt tggcttgatc 33061 ttaatttttt tttccttaga tgcctttggc atctcttaga gtcacgtagc atcctgtggt 33121 catttgaatt caaaacctag ccttcactgg atttgctaga cttgatggct ttgctccttt 33181 aattctctct ggaggtcgaa gaacccatct aagcttccga aggaaacgtt tcctttgtca 33241 tgcttggtgc ggccacatca accctcggga acaggtggcc ccgaggagac gctgttgctt 33301 cagcatcgga caagccaggt ctctgttggg gtttcagaat cttcttgagt ccctcactct 33361 tttctctcag ttctacatgg gggaaaaaag gaaggcgagt tctcaggagg aatgctcatc 33421 aagcaagctg gagttcgtat ggaaaatgca tccatccgga agagaacaca caagtgcctt 33481 gcttccctgc accgggtgtt tccactattg tcctcctggt cctccccatt agggaggaac 33541 agcccactgg gtcacgtctg ggctcttgct tcatcgaagc tcctataccc cagttcgggg 33601 gaaaattcac tctaaggcct tcagctctca cagagtaagg aaacgcactc acctccaatt 33661 agattacaaa ttggctgggt gcagtggctc atgcttgtaa tgccaagact ttgggaggtc 33721 aaggcaggtg gattacctga ggtcaggagt tcaaaatgag accagcctgg ccaacatggt 33781 gaaaccccgt ctctactaaa aatataaaaa ttagctgggc atggtggtgg acacctgtaa 33841 tcccagctgc tcagcaggct gaggcaggaa aatcacttaa aaccagaagg cggaggttgc 33901 agtgagctga gattgcacca ctgcactcca gcctgggtga cagagcgaga ctccatctca 33961 aaaaaaaaaa aaaaaaaaaa gttacaaaca gcctgcccag ggagccctca agctcagaaa 34021 cacttcctcc agggaacttt ggttcctctc cgaaccagct gccaataact gctaacaact 34081 aacattattg tgctttatgg ctctgattct aatgacattg gcaaaagaca tgaaacaaca 34141 aaaaactcca accccatact ttttttttga gacaggatct tgctctttca cccaggctgg 34201 aatgcagtgg catgatcatg gctcactgca gcctcaacct cccaggctga agcgatcctc 34261 ccacctcagc ttcccaagta gctgggacta cagccacgta ccaccatgct cggctcatta 34321 aaaaaatttt tttttcctag aacaaggtct cattctgttg ccagggctgt ctcaaactcc 34381 tcgactcaag tgatcctctg acctcagcct ccccaagtgc tggaattaca ggtgtaaaga 34441 cactgtacct ggcctcccaa ccccatatat atatatatat attttttgag acagggtctc 34501 actatgtcac ccaggctgga gtgcagtggc gcgatctcag ctcactgcaa cctccacctc 34561 ctggggtcaa gcgatcctcc tgcctcagcc tcctgagtag ctgggattac aggcacgtgc 34621 caccacgcct ggctaagttt tgtattttta gtagagattg ggtttcacta tgttgaccag 34681 gctggtctcg aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctgtg 34741 attagaggca tgagccacca cacctgggct aatttttgta tttttagaga ctaggtttca 34801 ctatgttgtc taggctggtc ttgaactcct gagctcaagc catccgcctg cctcagcctc 34861 ccaaagttct gggattacag gcgtgaccca ttgcgccctg cccaatccca tacttttgaa 34921 ggtgtcgttc cagcatggct cctcaggcac aggcccacca cagacagcag ggcctatgga 34981 ggcctgagca gagtttcctc atacttccct ttttgctgcc tcactctggg tccaccacag 35041 ggtggccttt ttcaggcttc tcttcctggt tcagttcatc gaccaaagac atggctccat 35101 ttgctaactg agacccaacc aaaataaaca ttcatggagt ggttgggcct tttgttgtga 35161 ccccttaggt agaggaaggg agagatatgc ccaggttctg tttggtgttt ctacctgtca 35221 atagagatac cacgttaatc attaacagcc atgcctccca gttagtaagc aagacaacta 35281 actggaacta gactttttac acaagttaga gatgatcttc atcggatgcg tcaacaatgc 35341 ctgaagccca gtgtcttaga aacaacactt gcccagggtc aggcgtggtg gctcatgcct 35401 gtaatcccag ctacttggga gattaaggca gagaatcact tgaacccggg agatggaagt 35461 tgcagtgagc cgagatcgcg ccactgcact ccagcctggg tgacagagcg agactccatc 35521 tcaaaaaaaa aaaaaaaaaa aagacacttg cttggacagt ttatgttggc ctctctgaag 35581 ttgtcaggga gaatgtttct ttcttctgat cttgctcaga gctcttttgc caacagctag 35641 gatggcctgg agttttcaag gctaagcgct gggattctgt tggttaacag tgatgggagg 35701 gaaaaaggaa aagaaatcca aaatttacaa tatggacagg aaaaggcaga aagaatggaa 35761 cacgggggca cacagcagtc tggctctgtc gtcccacctc gtgggctgcg atcatgatac 35821 aagtgcttgg cccctggaac ataagaagca ctcaataaat gctttgtcat aatgattatg 35881 tgtgcccagt gcctggtaca cagtaggtgc tcaataaatc ttaattcccg caaagaccag 35941 tctaaccttt gtctgggggt ggctcttggg ctgctggtgg ggtggtggtt agtcatagga 36001 agtactggat gagacaggag agggccatgg ccagggccag atccccctcc ccacccaacc 36061 gcctctactc cccacttttc tcgtcatgtt cgcaagagcc tcatgaggca gaatagagca 36121 gtgttaacca tccccatttt tcagaagggg aaactaaggc cctgagagtc atcctcactt 36181 agggcccttc aacgagcttg cagtgggtcc ctggctgtcc cacatctcct cctgttggag 36241 gtgggagcag aggggctggg gtgctgggag tgggacagtc cctcagagga gtggctgcat 36301 ttgctcatag gaagtccgag gcagcggggg ccttccaggc ccaggacgag ggacggtcac 36361 agcagcccag ccaaggccag agccaacttc tccgaagaca gtccagccct gcccccagca 36421 ggcaggtgag cactgccagc tgtctggggc cccgcacccc aaggggcggc cactgcctct 36481 tccctcccgc tagaagccag gcagggggct tggacaggaa ggtcctctat gaaagggtcg 36541 gagtccaatc atggggatcc agctctcccc tctccccaac ggccagcagc tcttggcaaa 36601 atgcacaaga ccccacatta atcctttgaa gatagcccct ctcccacgct atccccttcc 36661 tttactaagc actgctgtct tttttttttt tttttttttt tgagatggag tcttgcactg 36721 tctcccaggc tggagtgcag tgggacaata ttggctcact gcaacctctg cctcccaggt 36781 tcaagtgatt cttctacctc agcctcccaa atagctggga ttacaggcgt gtgccaccac 36841 acccaactaa ttttcgtact tttagtagag acagggtttc accatgttgg ccaggctggt 36901 cactcctgac gtcaagtgat ccgcccacct tggcctccca aggtgctggg attacaggcg 36961 tgaaccacgg cacctggcca atactgctgt cttgagcaga tttcagggaa agccttgaag 37021 caagaatctg gctctaaggg ccctctcttt cagggtaatt tgtatcttta accaaaccca 37081 gagggctagg cccgcctcag tggaatgggg tattggtggt ggaggttctg gcacctgata 37141 gcccaagttg gaatcagtat ctttgagagg ggtgagaagc caagaacggg ggcaggtctt 37201 tgcagatctt tttctggaac tgaggaaagc gggtgaaagg gaggagctga ccccggaggg 37261 gtggggcaga gaccctgtgt actttttggc ctgctttgat tcaggctgct gtgtggacac 37321 agccttgact ctctgggggc ctaagaaagg cagagctggc agccaggtcc ccagagagag 37381 agcctcacct accccctcac ctcatcccca ggtgaccatg ctccctgcca aacaggcaga 37441 actgacccgg cggagccaag cagagccccc tcatccttgg agtcctgaga agagacctga 37501 gggagatcgg cagctccagg ggtccccgct gccccccagg acatcagcca ggacccctga 37561 gagggagctg cggacacaga gacctctgga gagtggccaa gcaggcccaa gacagcctct 37621 gggggtgtgg cagagtcagg aggaaccgcc agggtcccag ggccctcata gacacctaga 37681 aaggagctgg agcagccagg agggaggcct gggccctggg ggctggtggg gatgtggaga 37741 gcccagcctg ggggcagcca aagccccgga gggagcatgg gggggcactt ccagggagta 37801 caaggagagc tgggggcagc cagaggcctg ggaggagaag cccactcatg agctccccag 37861 agaactagga aagagaagcc cactcacgag cccccctgag aactggggag gccccgcaga 37921 gtcctcacaa tcctggcact ctgggacacc cactgctgtg ggctgggggg cagagggagc 37981 gtgtccatac ccgcgtggct ctgagaggcg acccgagctt gactggaggg atctgcttgg 38041 ccttctccgg gcaccaggag agggggtctg ggcccgtgtc cccagcctgg actgggaggg 38101 cctcttggag ctcctgcagg ccaggctgcc ccgcaaggac ccagctggac acagggatga 38161 cctggccagg gctttagggc cagagctggg tcccccaggc acaaacgatg tccctgagca 38221 ggagtcacac agccagccag aaggctgggc cgaggccacc ccagtcaatg gacacagccc 38281 cgcactgcag tcccagagcc cggtccagct gcccagccct gcctgcacct ccacccagtg 38341 gccaaagatc aaagtgacaa gaggaccagc gaccgcaact ctggcaggcc tggagcagac 38401 gggccccctg gggagcagga gcactgcgaa gggccccagc ttgccagagc tgcaggtaag 38461 gaggtttcca ccctcccaag ggtagccaga aagtcagccc cactcagcca agtctccttg 38521 gaaaagcctc cccttggagt agcctaagct cctgcatccc cctccaggct cagacctcag 38581 cctccctgct gaccacaacc catcccgatc accaaactgg cccaacaatg atgatgagca 38641 acacagtttt aagcgtttat gggccaagcc ctgatctgaa tgtttgacgt gtgcttttcc 38701 catttagtct ccttagcaac caggtgagaa atacactatt tacagataag gaaactgatg 38761 cgcagggtga agccacttgc tggtggggca tgggcaaaac ccaggtctgc tcagtgcaga 38821 ccacactgag gcctcaagca agatgctctg gccagggcct attcccctcc tggctccacc 38881 atacctggtt tatgttgtgt ctggtggcac acacctgacc ccacctggga ctgtagccag 38941 tgtgggcatg ccccttcccc tggtggtact caggtacctg agtccaggac agcctcgctt 39001 accctctctg gcccctacag ctcctctcag acacagagaa gagggtgcat caatgctcac 39061 tgggttcagc tagctgccaa gacaggctgc ttaaatgagg gtcgtgtgca aagtgggccc 39121 agcgccgggc acacagtagg tgctcgccct tcccctgctt cactggtgct ttggtgctgc 39181 cttgaagccc agaacattct tcatctgaag atggtgggca gggagggtct tggaggccag 39241 aatcctgcac cctggcaata gctcattggg aggacggcat gtggttttga acaccagcct 39301 ctctctctct ctgtaagatg gaccaaccac ttctctgacg ggcagcgctg gggtgccgtg 39361 ggggttcctg cttgtttctc caaagcctcc tcatctccta gatgcaaagt ccaacgccac 39421 ctgccccagg atgagcaggg cttccaggca tcagggtgca ccccgtgctg ggcccagggc 39481 cttgccatat gtgcctcaag tggataggag gcagctgcca cttgacagat ggggaaactg 39541 aggctcagac tccttaggca tttgctgggg gtcacacatg cataggtcgt gagaaatgag 39601 atcaaagcat ccactccaaa gtttgtgctt ttatttttat ttatttattt acttattgag 39661 acggagtttc gctcttgttg cccagactgg agtgcaattg cacaatctca gctcactgca 39721 acctccgccc cccaggttca agctattctc ctgcctcagc ctcccgagta gctgggatta 39781 caggcatgtg ccaccatgcc cggctaattt tgtgttttta gtagagatgg ggtttctcca 39841 tgttggtcag gctggtcttg gactcctgac ttcaggtgat gcatccacct tggcctccca 39901 aagtgccggg attacaggtg cgagccacca tgcccggcct aagtctgtgc ttttagccac 39961 cacgtcacaa agctcctgag cccatgggag gactggagaa ccctctcccc tgtatttccc 40021 tgtggctttg atgagttgac cctccaatca actcaatgcg tggacatcag agaagcaggg 40081 ataagtcagc tcgtcctgcc ctcagattgc tgtcaggctt gttaggaagg cacacagaca 40141 gctcaaggag gacacggtgc tgtgtcccgg ggcatgctgg gtgccacagg ccggccaggt 40201 caagaaggaa gttagaaaga ttcttcagtt tcatggtgaa gctcagggtt ctcaggaggc 40261 taggagatgg tggctgggaa gggatgggag caccatgtac tgaaaggaat ttcacagatg 40321 acaaaacgag taaccaccag gtcctgctgg ggctccagct gctcctctct atgaaaatcc 40381 ttggcttggc acagctgggt gcagtggctc acatctgtaa tcccagcact ttgggaggct 40441 gaggcaggca aatcacgagc tcaggagatc gacaccagcc tggctaacac ggtggaaccc 40501 cgtctctact aaaaatacaa aaaattagcc gggcgtggtg gcgggtgcct gtagtcccag 40561 ctacttggga ggctaagaca ggagaatggt gtgaacccgg gaggtggaag ttgcagtgag 40621 ccgagatcac gccactgcac tccagcctgg gtgacagagc gagactccat ctcaaaaaaa 40681 aaaaaaaaaa aaatccttgg catggcactc aaggccggct tcccttcctt ccactccgga 40741 tttgcctcat tggtgctgag ctggctgcag ggcctgtgag cacatatccc tgcctttgca 40801 catgctcttc cctgttcagc caccaaacgc ctgttcattg tcgaagtctt aggtcaggct 40861 ccctgtcctg agaagccttc cctgaacagt cactcctagt aatggtcccc ttctgggctt 40921 ggcagttttg cttccatttg tccatgcaac atccatctaa tagggttgtc atttccccat 40981 aagctccaca caggcaggat ctctacctgc tttatctctg taactctagc tctggcccag 41041 ggcctgacat aaaggagggg acagctcagt ggatgcatgc aagatggagg acacaggggt 41101 cagtgggtga acaatgaatg aatggagggt gaatgtgtga atggatgatg gatcaatgat 41161 gcatgttgaa tgaataatag acatcttttg gatggatgac agatgggtga tgatggatgg 41221 atagctgggt gatgaatata tggtggtggt ggatatatga tggatgttgc ttaggtgatg 41281 gatggatgaa ctttgggtgg aatatgaatg gatagatgtg gcatgggtgg atgaatgtca 41341 gatgatagat gttggagata tgggtagatg gatgatggat ggagagaggg atatgtaggt 41401 attgggtaaa tggatatgtg atggatcaat ggagggtaga tacatgaatg ggtgatagac 41461 aatggatgat gggtacatga gagggtgagt catgtgatag acactggatg gttggatgga 41521 tacatggatc tactgatgct ggacgttaga tgggtgttgc atggacagat gatagaatgg 41581 atggatgagg tggacagatg catgcatcct ggagaataag ttgggctaag ctgtgttctt 41641 tttttaatct ccagttccaa ccagaggagc ctgaggagtc agaaccaagc agaggccaag 41701 accccctgac tgaccagaag caggcagact cggtagctgg gtcatgggtg tgggtacata 41761 cggtggggaa gggaggggga agcaggttgg agatgggctt cattcctcag aagagcccta 41821 gaatcaacca gaccaaagtt ggcattgcca tggggtcatc tatgtgcatg gtggggcctt 41881 aagaagaggg gctctgcagg agccaccttc tggcttgggg acctgggtag gtgggcgatc 41941 ctggggtcag aaccctaggc catgcttctc atttgctggg actgaaaagg tcaatgtctt 42001 tccctgcgca aatgatggtt tggccccagt ggtctctgtg ggaagagatc cttccggttt 42061 gaaagggcca ggccaggctg aaagagcagg gcttccacga gcaggagcca gagagctgag 42121 gatgtaccca gtcagccagg cctggagggt ctccagggtc ctggaggcgg gagagatatg 42181 tgcgggggtg ggacccacgg atgctgctct gaggcctggc tgcagctggt gagcacaact 42241 ctgcccgccc ctccccgtga cctaccaaac agactgttct cgtcaccctc agcctccaga 42301 gaggtgagat cagagttgag ggccgtgggg cagtgggagg tgggggagga ggagacagac 42361 tgtttggggc tgtgttttcc ggtcctgctc ttcctcccgt tgcctcctga agccaggggt 42421 ggcagggagc gtccattggg cagcatagcg ccccccaagt agggccctgc cgtgagtcaa 42481 agctggggga attctgccca aaccctcact gtgcagatga ggaaatggag gcaggggagt 42541 cgtcccaggt tatacagtca gtggctagct ggactgggac tagaacccag ggcccaggaa 42601 ccacccagcg ctctctctgc acctccacct ggcacccatg ctgcccccgt ccctgccccg 42661 atttcttgcg tggcttcgaa cggcagtgct gtaacttcga gcagtccagt cttcccatct 42721 gtggaatggg cggggacagg ggacactggt cgctaaaggc gctgccagcc ctcccaggga 42781 ctctgacaac tttgctcttc ctctttctgg gttatttctt catatcctgg agccagagta 42841 gtgaacgagg cggaaacagc aatgccgggg tgcccctcta gtctccatga aacgggcccg 42901 gcccatcaac gtggaaaata tctcaaccta cccccacccc taggcagcct tgactggtca 42961 gaactgataa ccacctcatt catgcattct ttcacacaca cttagtgagc accttctgta 43021 tacccaggtg tgggtcacag gtgagtcgga gcgccatcaa agagttcagt ctagtgagat 43081 ggttgcatgc ctgtggtcag gactgtgatg gggaatgtgg tagcagggtc gggggcaccc 43141 ctacccccaa agccctcctg gacctgtgct ttgatgcttc aagttccact tccaaagagt 43201 ctgcagattc cagagcgagg accctgggct ctctcctacc ttcccagtaa cccatgtgtg 43261 gctttggaca agtgcctctg cttcacaggg gccttggttt ccccaacgag gatgactcca 43321 aagagggagc atttgggggc tctgctagga atgtgtgtag aagtccacaa ctcattccct 43381 ttgcttaagc tggggtcaca aacctaacgc cctgaaggcc aggcaggtaa caatggtgag 43441 aaggtggggg ggcaccgagg gcacttgtgt gactcctcgg ttccagatag ctgttgccat 43501 ggggaagacg ggcccagagt ttccacatct ttcgatattt caagaaacac tggagatatg 43561 tatttatatg tgaaatctct aacctaatgt gaaatactct gaaaacacta tgtgggcaga 43621 aacatacctg tggtctgcac cccctccagc tggcgcccgt ggtttgactt tagggtgatg 43681 acgtgcacac cttcaaaggt gctgagccct gggagccttg tcagtccaac acgatgtagt 43741 gtgaacaagt taaccagctc gtctcggcag ttctgggagg agagaaagat gggaaccctg 43801 gggctccatg gtggggggca ccacagaatg ggcaggggag gctgtagcca ggggtgcccc 43861 catcctgcca aagggacctg gggccaacac tggaccctgt ttgacaggca gacaagaggc 43921 cagcagaggg caaggctggg agcccgctca agggccgact ggtgacctca tggcggatgc 43981 ccggggaccg gcccacgctg ttcaatccgt tcctgctgtc tctgggggtc ctcaggtggc 44041 gaagggtagg ctggctccag tggggactgg aggggtgagg gtggatagag acggggatgg 44101 gagggaggag ggggctgtta agcaaaggag agagagtggg ggctgaggag gaggcaccta 44161 gggccgtcgc atgacaggag aggtgggagc agagctctta agctcatcct ggtctcagca 44221 agcgagtggg tttcccactt ccggggcagg cttgggggct gctttcagct tttggagtga 44281 ggggtgatgg aataatctac acagctgaaa gcttccaatc agcagcctct cgccagccct 44341 gggccaacgg ggagccaggt atgggggaag ggaaggcgag cttataagtg gctctgggat 44401 tgcaaagtgt gtctcagacc tgggcctgag ccagtttcac aaacatctgg cgttacgtaa 44461 cccatcccct gcccagagag gcctggaaac actcaagcct ctggctgggt tttccacaag 44521 ggcaggcagc tgagacccgc tccctcccac ccgcttcaca gcaggacaga aggggcctgg 44581 ccatctccag cagccacagg ctggctcatg gggtctcttc tctctttgag aggctgactc 44641 tcttactcac cgctgttggc tctgagtcca gcactaggct gggcacctca gagacagtgt 44701 gcccatttta cagatgaagg gactgaggcc cagggaggtg agctgacttg cctgaggtcg 44761 cacagcttgg ggtataaagg agctgatttt cctcattctc agatgagaga agggttgtag 44821 ccaaacttac tgagcctcgg ttgccacatc tgtctattag gaaaaagtct gtggagactc 44881 agggctgcag agagggctca gggagatcag gatgcatgga ggttgcgggg ctgttgtcga 44941 aacactaact ttcccatcca cttcagaatt tccttttttt aaaaaattaa gacggagtct 45001 cgctctatcg cccaggctgg agtgcagtgg caccatctct actcactgca acctctgcct 45061 cccgggtcca agtgattctc ctgcctcagc ctccagagta gctggaatta taggcgtgcg 45121 ccactgcacc cggctaattt tttgtatttt tagtacagac agggtttcac catgttggcc 45181 aggctggtct tgaactcccg acctcaggta atccgcccac cttgacctcc aaagtgctag 45241 gattattggt gtgagccacc acgccaggcg tttttttttt ttttttttta aattaagata 45301 gagtctcgtt ctacccccag actggagtgc agtggcacca tctcggctca ctgcaacctc 45361 tgcctcccag gttcaagcga ttctgccatc tcagcctccc gagtatgtgg tactacaggc 45421 gtgtgccacc acacctggct aatttttata tttttagtag agatggggtt tcaccacgtt 45481 ggccaggctg gtttccaact cctgacttca agtgatccgc ccgccctggc ctcccaaagt 45541 gctgggatta caggcgtgag tcacccagct gagcccagaa tttcctttcg ctgctctttg 45601 tggttaaggc accgagggtg agcaggcaag catggttatc tgagtagtgt ggtaccttta 45661 agccatgggc aggaattacc ttgtctaact aaaggtcacc aacacacagc acgtctggca 45721 ggagggggca ggtaagtcct tggtagagcg aaggaggagc gaagcaggga aagcactctg 45781 gggtaatgat gctggctaac cagcacttat tgtatgccta ctacatgccc agctctgtgt 45841 tcactgcatg gcgccaccta attgcatttg atccacactc ccaggtgcag ttagacgcct 45901 actgtccatt ttacagatga tgaagtgaag ctcagagagg gagggtcact tgctccaggt 45961 cacacaggga gcaaggggca gaactgagat tcagaccctg ctctggctga cctcagagcc 46021 cagtgcttcc aacacgcccc ctacaccact gccttcacat cctgatctct ctgagccctc 46081 ctgcagctct gggagtcccc acagattttc cccattagaa agatgcggca accgaggctt 46141 ggtgaggttg gctacagtgg ttctctcatg tgggagtgag ggaaatgaag agctagggat 46201 ggaactgcca gcagggcctc ccagttacac agagcagatt taaacttctc ttgggctgaa 46261 gcagtgaaat tagcccaagg ccaagagcca gaaagcctgg agtcgagttc tggcttggca 46321 cctaacttgt gtgcccttct ctgagcctta ccttattatt ctcagtagag taacggtttg 46381 agactggata acctcgaagt ttggtagctc tggtctttgc cagtttaata actcacccct 46441 gggtccctga ggctgtgctg tctctgacct gccaggatga gttgtggttt cttcattggt 46501 gcattcattc attcgagccg tgcttacgga ggatgtgctg tgggcttagg ccctaggctg 46561 gtttccaaga tgtagacaaa aaacattcca gccctggcca ctggagccca gttaggtaag 46621 gacactgaca tgtaactgat gagaacagtg tggtcaccac tttagtgggg aaaggtacag 46681 atgtagggag cactgggcca gcagttccta agtctgctgg ggacactttg gcttcctttg 46741 gtctgagact tcaaggaaga aattttccag gccaacaagc attgggaggg ggaaggggag 46801 aaagagagag agaatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgct 46861 gggtgtgtgt gagtgtgtgc tgggtgtgtg tgtgtgtgtg tgctggggta cagaagacag 46921 gaagagaagt gttccaggca cagcagagaa ccatcagggg gtagaaggac ctgtcttatc 46981 ctgggaattc ctagtagtcc agtgctgtgt atcttttttt tttttttttt ttctgagatg 47041 gagtctcgct ctgttgccta ggctggagtg gaatgcagtg gtgtgatctt cactcaccgc 47101 aacctacgcc tcccaggttc cagcgattct cctgcctcag cctcccaagt agctgggatc 47161 acagccatgt gccaccacgc ccggctaatt ttttgtattt ttaccagaga cggggtttca 47221 ccatgttggc cagcctagtc tcgaactcct gacctcaggt gatccacccg cctcggcctc 47281 ctaaagtgct gagattacag gcataaacca ccgcgcccag cctccagtgc tgtgcatctc 47341 tttatttact tattgtattt tgcaaaattg accaaagtat gtgtctctcc agcctgtcaa 47401 atgagaatct ggaaggccag gatgacaggc aggagccagg ttgtgatggt tcctgactgc 47461 ctagaagagg aatgtagcac tgatctgtca gcattggtga tgtgtggaag aactttgagc 47521 agggaagtgg tctggtcact gtgttgcggg tactaggagg agtcgcaggg gccagaaaag 47581 cctggaggag gctggtgctg ttaggtgccc agggcactgg accaggaccc tggtggtagg 47641 tgaggtctcc tgcgtgttca ttcactctcc caaggactga ctgcctgagt gaggtgcaag 47701 ggtagggtga gaaaactcag cccggggtgc cagaaggcca gtttctagag ttagatggac 47761 ttaaccttgg cctcattcct catggtggag agactcctgg cagcaaatgc tgggaaagaa 47821 cttcagctcc ctgggcctcc atttctttat ctgcaaaatg ggaacagtaa ttataaaagc 47881 aataattttt ttttttgaga gggagtctcg ctccgtctcc caaggtggag tgcagtggca 47941 caatctctgc tcactgtaac ctctgcctcc cgggttcaag cgattctcct gcctcagcct 48001 tttacatagc tggattacag gcgcctgaca ccacgcccgg ctaatttttg tatttttagt 48061 agagacgggg tttcaccatg ttggccagtc tgctcttgaa ctcctgatct caatgatcca 48121 cccacctcag cctcccaaag tgttgggatt acagacctga accaccgcgc ccggcaaggg 48181 caataatttt tgaaccccaa atcaagatga cagaataatt gaaatgccaa ttattccaag 48241 cttccctgcc tccttgccta aggatagcta atgagggata aagaggttgt cctaggtgcc 48301 ttacttgaat taacacttaa tccttccagc aacctcatga ggtaacagca ttaccccatt 48361 ttacagagag tgaaattgag caccgagagg tgccttgctt aaggtaacac taggctggaa 48421 tccccgtgcc acacgaactt cctagtgcat ttagcaacca attccaccac ggtccctact 48481 cacctgcagg aaaagagcat ctaacaaacg gcccagcgtt ctgggaacct gagcaacggg 48541 tgcacgccca cacctgaaaa accccaaacc aaaaaagacc catttgtgag gagtgggcat 48601 ttgggagaga ccctgccatc caagaactca ctttgtgtcc agcttactcg ctaggaattc 48661 cgcctcttcc tgtgtgacct cgggcaaatc ggctcacccc tctgagcctc cgttttctca 48721 ttagcaaaat aagacctccc tcccaagtct gtggtgagga cgaaaatcga ctcttggcga 48781 gtgggacccg ctgagtcgtt agtactgggt gctttgcccc ggtccccgcc aaatcacggc 48841 gccgagccct agcggaccca tcgctccggg gccgggtcgg gaagcgcagc ctgggcgagt 48901 cgtgcccacg cccggccgcc cgcatcctcc gcccccgcgc cattgccgga gtcacctgca 48961 ccctgggccc ttccttcctc ccagcgcgcc cgcggcccgg gcccgcccgc cctccggccg 49021 ccaccgccct cccttccctg cggccccatc cgcccacccc gccgtcccgc cgtcccgccg 49081 ccccgccgcc ctagcgcgcc cgtcccgttg cggcaggtcc cgcccccggc ccgtctcgcg 49141 cttccattgg cccgccgcgg cccccgccgc tgtttgtctc ggcttccccg ccacccattg 49201 gcccgctcgg gtcctcccag gaagtttgaa aaaaaaaaaa aaaaagtttt atgggcggat 49261 ggaaggggcc ggggcagcgt cggggaaagg aagggccgga ggcgcggcgg cgggcggccg 49321 agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc gcggagcccg gcccgagagc 49381 cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg cgccgccatg acggtgagtg 49441 ccccagtcag ccgcccgcgc ccgaggccgg gagaagggcg acgacccgag gcagagccca 49501 gcctctcccc tccggggcag ccccctcctc atttcccgaa ggcgagagga gggctgggcc 49561 ggaagacggg gccacctccg aagcgctttc ggccagaccg gcctcaccct tcccgcaggc 49621 tcctcctcgc cttccctcgc ccactcgccc ccgggagccc aggcgaccct gaggggacgg 49681 aacgacccgt ctcgggcgcc ccctcctcac acttgcggca ccagtcacgg gtggattcgg 49741 ggcgaccctt tcccacctcc cctccagccc cctagacgaa gacccgattc cccaaggcgg 49801 ccaggggccc cagggaggag cggaggtggg cctgggctgg ggaggggcgc tcgtgggtgc 49861 ggatgggtcg cgctgacccg ggcctgggca agccagccct ccgtgtggcc gctggcccga 49921 ggtcgggtgg gcgagaagtg gccggaccgc cccacccaca gcccgggagg cagtcccggg 49981 acgtctgaag cagcgggata ccacgtcttc ctgggcttgc actttgcagc ggtcctgggg 50041 ccttgggaca agcctgcgag tctgagtagg gggcatgatg gcaggggttt gcctttctca 50101 tgggggtgag ctgtacccaa gccccatcaa ttacctgtgc catagttagc atattgagcc 50161 tcacagctgg gttcgctgga ctccccactt cacagccaga taaactgagg cttggggagg 50221 ggcgctggtg agttgcccga ggtcacccca agtataagag aaggagtagc tcctttccct 50281 gtccttctgg cccactgacc gtgatgttcg ggaagggagg ggtggggctg cttttggttt 50341 ctggctagtg cttcagggag gctctgacag cccagtggcc ctcctggggg aggatgagca 50401 gggtgtgtgt gtgcacaggc ggcagtaggc ctctttcagg ggagtggaga ccctgcggag 50461 gagtgggtgg gctgctgggg gcgggctggg ctgctggggg gcgtggcacg cctagcccct 50521 gccctgtgag tgtgatggcc tggacttcct cggcgtcctc ctggacatcc tgccacctcc 50581 ctgctggccc ttcctgtcgt cagcagcctc cccttttctg tcaggagcag aagggatgtg 50641 gggggaggag ctgagtcagt gtcctggggc caggaggaga gaagttgcct tgcccaccgg 50701 gtgcctgccc ggccctcagc cgggtgcttt cacgttacca gatttgatcc ttgaaggttg 50761 gtagtaacat cttaatcaaa cagatgagga aaccaaggtg tggcgaggtg aagtgtcatg 50821 ccccaggtaa ctcagtgagt cccaggctaa gccagaattt gtatccaggt ccgttccagc 50881 tttctttcac agttgcctgt cctgggggca gcacgtgctg agcaagggta aggctgccgg 50941 aagcagcgtg tggggtgctt ggaagatgga cagcacatcc ctgctggtgg cagcagcctt 51001 cctgagggag gtgtcctcct gtgattatag ggccttgtca ggtggagatg gactagcgag 51061 gagacagcag tgtggacaga aacgggtggt catgtttgag aagtagcaag agcgtaggga 51121 aggggtctgg ggaggagggc ctcactgcta gggcttggac aggggcaata gagagccatg 51181 aaagctttta gagcagagag gaggctatga tcaccattaa tagtgttcat tgagttcatc 51241 ctggctgcca tgcagacctc agcctgctct cagctggtgc tcctcctgta cccacctcac 51301 accctcctcc cctggccccc gtgccctgaa tcagggatcc atacagagca agtggcacag 51361 gtgtgtgagt gtgtgaggct ccggggcttc agggagttgg gattctcttc cacccctttt 51421 gcctttgcct gggtgcagct ttgctcccgg atcagccttc cccctcgcct gctgggcatc 51481 aaattatatt tggtcccttg tttactgtct ctttcctaca gtccaccagg gcaggggcca 51541 cagctcttgg tcacagctaa tttcctggcc tagaacagtg cctgataact ttaaaaaaaa 51601 attttttttt ctgcaaacac tccctgagcc cctatctgtg ctgggtcctg gcaggtaaac 51661 agtgtatgtc cctgactgtg agttgcatct aatctagcct gtgaaggata agtaaagggc 51721 ctcaagatag tcacggatgc aacagaggcc tctgagaggg gccatgggag ggcaggacgg 51781 gggcggctgg tggtgcggtg agtggcatga actgtgaagg gacctcagag gtggccatta 51841 agctgggtct taaggcctga gtagccgctt gcctagtcat cggaggagga ggaagcatag 51901 tgtttcaggc caaggacatg gcacatatga agggcccgga gtcctggtgt gttgtgatcg 51961 gcaaggaata tgcagtggta taaacagggg cccctcagca aggggaggcc aggctggaag 52021 agtgtgatga ggcttccctg ccatcctgag gcagctggac tttgttttaa agccacctgg 52081 agaccgggtg tagtggctta tgtgtgcctg taatcccagc attttgggag gctgaggtgg 52141 atggatcact tgaggtcagg agttcgagac cagcctggcc agcatggtga aatcccatct 52201 ctactaaaaa taaaaaaatt tgctggacat ggtggtgggt gcttgtaatc tcaggtattt 52261 gggaggctga ggcaggagaa acgcttcaac ccgggaggtg gaggttgcag taagccgaga 52321 tggcgccatt gcactccagc ctgggcagca gagactctgt ctcaaaaata aagcaagcca 52381 cctggagccg tccctggaac tgttaagcaa gcctgggata ccaagccttt ttgagtgagt 52441 cccgccagcc cgagggtgtg tagaggggtt gtgtgcctgg ccaggtagga ggcggggctg 52501 tgagaacctg ccagtactcc cgaaaggcgg aaggagaaac tgagcttcta gcaggtgaag 52561 aagaggtagc tgggcctgaa gagccctgta tgaaggggca tcgtgggaga tttagatgat 52621 cggacctttt gaccctgggg acaggtttcc ctgccagttt aaaaactcac attggttggc 52681 cgggcacatt ggctcacacc tataatccca gcatttttgg aggccgaggt gagcggatca 52741 cttgagctca ggagtttgaa accaacctgg gaaacatagg gagaccccat ctctacaaaa 52801 aaaaaaaaaa aaaaaaaatt agctgagcat ggtggagtgc ttatgtcgtc ccggctactt 52861 ggaagctgag gtggaaggat cgcttgagcc caggaggttg agtcagcagt aagctgtgat 52921 cacaccacca cactccagtc tgggcagcag agcagggccc tgtctcaaca aaacaaaact 52981 caaattggtg accttctatc cccaaggtca ctgtgtcatg gcgtgcctga catggtatgt 53041 gatgtgtctg tactgggctc tggaggatca ctaggtttct ccttgtacag acacgttcag 53101 tcctgtcgga agctgcggga ggggaggacc gccccgtcat ttgccacatc aggcagccag 53161 gactcagaga ggggatgtga cttaggaagg tcacagtgac tccacttccc aggcagccct 53221 agaggttcca gcctgacagc ttgtcattcc tgccccaatc tcccagccct ggcccaggga 53281 ctttcgcctg ggactgccca gtggtgccag ctctgtgggc ccaggaagcc tggctcctcc 53341 gggctaggtg ggggtagggg agatggccca aaaagcacag aaatttagac cagggggtag 53401 atatttcctc agcaagtttt tcctgagcct tgctgtggtc aagccccctg caaggccctg 53461 gggccacagg aggtcccaga ctgaggggaa gtggagccag gtgtggtcac caatcttcat 53521 tcttagcttg ggatcgccct gggcagcctc cgtctcaggt ggaagacggg gtgggcagaa 53581 tacagagcag cgggacaaac gcagccccag gggttctcgg ccgtgagcag agcctgtgtc 53641 tctcccttag acaggtatac agggaggggc tgggatgcca acctactggg tcccccgact 53701 gtggctgtgg aaggttctgg atcttcagct gtcccaagcc ccggttggtc cacttcctat 53761 acctgagaag gggctccgtg ggtggagagt gggtcgggag aggtggccag gcagggtggc 53821 tgtggtttcc agctgccact gtcaccgccc actccactga gccatgccac ccgttctctg 53881 caggcaacca gacaccttgg cctggtgagg cctcgatgta ggggctgata ggtaggctca 53941 gagccatggc aaccggtggc cacctcctcc ctgccggcgc caggagcgga gactgcagag 54001 ggaccgggac ttagatgaga gaggtctccc cagcaggaag ggagggtctg gtggttggca 54061 cccactagat gagcatggtc agaaaaatat caggatgagc aacttcttta tctaggcctg 54121 ggtgggggtg cctggcacag gtctccatgg gacatgctgc agctggtagc ccccagaccc 54181 cggggctgtg cccccctggg cggcacccag aaggtagggc ttgccaggac tgacccttcc 54241 caaagagatc taggcgggga ccagagggtt tctgacccca gcctgtgact ggctccacct 54301 cccatagtct cctggagccg aggaaaggac aggactggcg ggcccatggg agggtccgtg 54361 gggcacttgg tcctcgtcag agggaggaac tggacagttc gcgcagtgct gctggtctgg 54421 actgccctct gagctctcag ggggtctcta tgcaggcaga gtcctcccag cccctctctc 54481 ccattcttgg gcgaggggtc ggctggagag aggcccctgg gacatctggg tgtgtgtgcc 54541 agccacccag cccaacttct tggctctctg agtgccacta tcaggaaagg ggccagggct 54601 gcctcagtgg ctgggaggcc tgcttggact tgggggttac ctagggcctt agccctcttg 54661 gctggcttcc caggagctcg gtcccacagg acttggggac agggtgggtg cagcacgctc 54721 ccctcaccag cccccattgg cttcctgctg gacccaactc acctccctcc tcatctcccc 54781 acagcccgat ctgctcaact tcaagaaggg atggatgtcg atcttggacg agcctggaga 54841 ggtaagagga ctgaggccgg aggggaggaa gctggcttgt gctgctgctg ggcccctggg 54901 cagcccagga gtgggggtgg ggctggggct ggtgtgagaa ccctgggggt ggggctggga 54961 ggggtggagg ctgcccatta ggcttctgcc tcctggagca gtctgcagtg tgtaaaaggg 55021 atcacagcaa ggggccgtct agcccctcac acccagtgcc ccatcccttg atctcatcaa 55081 gagtctcttg gccctgccac ctcagtagga gcctgggtgg gagtcaaggg tcttgggtgg 55141 aagggctcgt agaagctgtc tggcccgaga cacagattcc taaagcctgg tctgaggggg 55201 gtggggctca gggcgcaggt gctggggttt cacccacctg gatccccact ggttgagtca 55261 aagcctcctc tagtcctcag tggccacgtc tgtgacatgg gcataatgga taatggtgat 55321 tctttctaga gtggataaca aggtcagaga gatcaagcac gtacaggtgc cacaaagctc 55381 ctggcactta ctgtgggctc agctaaagac ccttcccttc ctctggcata tgtgtccttg 55441 gaaccagcag ggacagtggc tgtttcctca gctctgttct ttcggctgcc aggctggctc 55501 cctgcccaca ctgcctgggc aggagcgtct ccccacccct gccctgcatg cgcctgctgc 55561 tctggtctgc gtgcagcctg catgccggag agggctttga gccagagggg atttcattgt 55621 gtttccggcc cacatgtttt attccctcca gcccacagcc ttccctaccc gctgcctgcc 55681 cgctgtccct ggtggctgct ctctaggctc acacaaagcc cggcaccccg ccagtgaccc 55741 cttcctggcc tccccaccca gggtccccgg agggcagagg gattacaggc cccacccaga 55801 gctggccatt agtcatcctc tatcacaggg ttctggaatg tccgaactgg aagggccctg 55861 ggaattcagc cagcccaacc ccttggtgca cagacaggag acgggcccat gagggtgttg 55921 gtctcttcca ggcctaggag cacctggggc agacccaggc tcagaactca gcgcacctga 55981 ggcccatgga gctccaccca gcttccatct cagacagtca taggctaggc ctggaagagc 56041 taaagaaacc tcttggcata gaacccctgt cctactttac agagaggcaa ttgaggtctg 56101 cagcagcaac tccgtttact tagtgagagg aaaatgcttc taagaggcct ggcctcccag 56161 aacaaaccca gcaacctggt tggtgtccat ccctatgcca agggccatga cagccatcca 56221 cacaagagag gatgggcgcc gctcgcctca ccagaaggtc taggcacttc tttttttgtt 56281 ttttattttt gttttttttt ttctgaggca gagtttcact cttgttgccc aggctggagt 56341 gcagtggcgc aacctcggct cactgtgtct tccgcctccc gggttcaagc gattctcctg 56401 cctcagcctc ccgagtagcc gggattacag gcatgcgcca ccatgcccat ctaatttttt 56461 tttgtatttt tagtagagac agggtttctc catgttggtc aggctggtct cgaactcctg 56521 acctcagatg atccaccctt ctcagcctcc caaagtgctg ggattatagg cgcgagctac 56581 cgcgcccagc tatagggact tcttagtagc cctactttat ggttcagaag actgaagctc 56641 agaaaagtgg agacacttgc ctaaaggcac acagagagaa agggaactct tggatacaaa 56701 actccttttc tcagggaggc aatgtggaaa gaagcagaag gtatcgtcgt tgcatgcccc 56761 ttgagaactt accatcttct tgaggagaga aaactaagta cttgaaacaa ccaacagcac 56821 agacagggct tggtgatgtg agggaaccct gggagggctg gggaccgggt gatatgcact 56881 gaccctggca gtgggcgggc cgcgactggc attccagtgg agtgaccaga agcccagagg 56941 tgggctgggc ttggcatact atcaggctgt tctggcgccc ccaccccttt cctacatgtc 57001 ctgccaatct aaccccagct ggagcagaga caggcactgc aggaaggcac ccaatcacaa 57061 atcctaaact tacagcttag ggcgctctca cctgctgcgg atgtgggtag ccagcctaca 57121 gttcaagaag cagaccgtgc atctgggcgc ggtggctcac gcctgtaatc ccagcacttt 57181 gggaggccaa ggcaggtgaa tcacctgagg ccaggagttt gagaccagcc tggctgacat 57241 gatgaaaccc tatctctact aaaaatacaa gaaattagct gagcatgatg gcgggcgcct 57301 gtaatcccag ctactcggga ggctaagaca ggagaatcac ttgaactcag gaggaggggg 57361 aggttgcagt gagtggagat tgcaccattg cactccagcc tgggcaacaa gagcaaaact 57421 cctccatctc aaaaaaaaaa aaaaaaaaag gcagcagatt gtggctggca ctcactccta 57481 ctccagggct ccatccagtc ctacttccca ggggaccatt gtccctgacc atggtgatga 57541 tctgggggaa tatggaaaaa gacgtaacgt cctggccccg ctgagtccct gacttgctta 57601 cacaggtcat cacccctccc tgtctgcact gggtccgggg tgcctgagga gccttggcaa 57661 tcttaaaagg agctccaaga aggaaaggga gggtgtggtt acggagggga aaccaatcca 57721 tttcacagat gctacccctg aggctcagag aggaaatgga ggggccaggt ctcaaattgg 57781 cattttccgc ctccccaccc ctcctgtgtg cagcatagtg agtttggcag ccacacagga 57841 cacctgtaca atcacacaca ctggctcttt cattccatcc tccttgcagc ctccctcccc 57901 ctcgctcacc accacctcta cttcgcagtg gaagaaacat tggtttgtgc tgacagattc 57961 aagtctcaaa tattacagag actccactgc tgaggaggtg aggccatggg tgtactgatg 58021 aacccccgga agggcctggg gtggcctggc tgggttcact ggggtgggtc acaccagggc 58081 ccacacggac catagtgggc cctcttgctc caggcagatg agctggatgg tgagatcgac 58141 ctgcgttcct gcacggatgt cactgagtac gcggtgcagc gcaactatgg cttccagatc 58201 cacgtgaggc tgtgtgcagc ttgggggctg gtggtgggca gcatggctgg aggtccctgg 58261 gggaggtttt ggtgttgaac atggctcacc atggagactg gatcccttca ctcatttacc 58321 cagaggccct atcttcagag ccagagctgt gatgccaaca cttagcatat ctgggggaga 58381 cgctggagcc agcagggctc ttcccaggcc aatggaaggg aggttttgta ccccctgccc 58441 accccagact caagacctta gatgcatcct gggaaggaag ggccaccctc cctggggtcc 58501 atagtgggga gggagtcatg cggctggcca tgtggcaacc tacccatgcg gtggccttgc 58561 agaccaagga tgctgtctat accttgtcgg ccatgacctc aggcatccgg cggaactgga 58621 tcgaggctct gagaaagacc gtacgtccaa cttcagcccc agatgtcacc aagtacgtac 58681 taagctggac tggggccttg agggaggcac ttacccttgc gtccccgagt gggtttctag 58741 gtactcacct gagggctgca cctttctggg ccctcgtttc tctgtcaaca acatgggaag 58801 agagtagtga gcattctcgg tatcatccag aagtacactg agggtttgag gtttgatctg 58861 tcttctcaaa tgtgatgggg cctcttctct ttggaggaga tgcctgtgag tcaaaagccc 58921 ctgccaggtg gctgttctgt ctctgtgtct gtgccgtggg ggccgtgtct aagcctgtgt 58981 taggaagggg tggttaggta gttcagcctt ggcgcccaca cctcccggga tggggagctc 59041 actccttctg gaggctgcca cgggcactgg ggcaggaggg ctgagttacc gagtggcaga 59101 gccccccaca gtttataccc agatgcccat ggcgggctgg gacttggagc tgctgggcag 59161 cgggaacaga gtgtggtatt aaagggggct gggctgggtg tagtggctca cacctgtaat 59221 cccagcgatt tgggaggctg agatgggagg atcacttgag ctcaggagtt caagaccagc 59281 ctgggcaata tagtgagacc tcgtccctac aaaaaattta aaaatcagct ggccgtggta 59341 gggtgcgcct gtcagctgag gtgggaggat cacctgagcc cggaggccga gtcccccaga 59401 ctggccacac cgcggctatt cagccttagg ccagaggctt tcctgtctag gtttcagagt 59461 ccccatctgt cacgttagca tgtcatgtct gtacatgtgc caggatgtgc ccagagcact 59521 ttgtgaactc tgaagcactg tgcagttgga ctgttattta gcatctaggc ccagctgctt 59581 taagaaagaa accccgggca cagtaacttc atcgagatag atgttcatgt ctcccttcag 59641 aacagccccg aggtatgcag tcctggcctg gtggggctcg ctctgccgtt tcaggggagc 59701 cacctgccac acccactcgg cagcctatag tcacatggct acaagtagct gtgggaatac 59761 tgcgagtgta gtttttggca gggtgaccac gtacccagct atgactgtgg ataaagagaa 59821 ttgccatagt tgttcagagt ctctgcaact tgtgttctgt gcaccccgag gtcccgcctt 59881 caccccatca gcagtgactg ggcatccccc ttgccactgt gagcctcggg aacctgggac 59941 attggtctcc tacatcacct cattgatcac catttgcaaa aagccccctg cctgctttcc 60001 acgttcgccc accctgtcct cacatccatc ctgtgagagg cgtcgctgtc ccacattaca 60061 gatgaggtca ctgaagctca aagagggcaa agagaccagt gtggtggttc acgcctgtaa 60121 tcccagagct ttgggaggct gaggtgggag gagcacgtga gcccaggagt tcgagaccaa 60181 cctgggcaat atattgagac cccatctcta tcaaaaattt aaaaaattag ctgggcgtgg 60241 tggtgcatgt ctgtagtccc agctactcca gaggccgagg caggaggatc acttgagcta 60301 aggagtttaa ggctgcagtg aactatgatc acaccactct acttcagcct gggcagcaga 60361 gtgagaccct gtcccttgaa aaacaaaaac aagaacgggg gcgagggaag ccgggcatcc 60421 tggtgggtcc ctgggctgtc aagaggtgga gctgggatgt tcctggggtc tgttaaccag 60481 gaagctcagg tcgggctgct tccttccctg gggtctgtct ccagcccctg gcacagggcc 60541 tggcacacag gtgtcgctcc aaaagtgctc attgtgggac tgcaggggtg aggacccacc 60601 tgacgtggct ctgctggtgc cctaggctct cggactctaa caaggagaac gcgctgcaca 60661 gctacagcac ccagaagggc cccctgaagg caggggagca gcgggcgggc tctgaggtca 60721 tcagccgggg tggccctcgg aaggcggacg ggcagcgtca ggccttggac tacgtggagc 60781 tctcgccgct gacccaggct tccccgcagc gggcccgcac cccagcccgc actcctgacc 60841 gcctggccaa gcaggaggag ctggagcggg acctggccca gcgctccgag gagcggcgca 60901 agtggtttga ggccacagac agcaggaccc cagaggtgcc tgctggtgag gggccgcgcc 60961 ggggcctggg tgcccccctg actgaggacc agcaaaaccg gcttagtgag gagatcgaga 61021 agaagtggca ggagctggag aagctgcccc tgcgggagaa taagcgggtg cccctcactg 61081 ccctgctcaa ccaaagccgc ggagagcgcc gagggccccc aagtgacggc cacgaggcac 61141 tggagaagga ggtaggcacc acggctggct ctctaggagg ccccttgccc cagcgcccct 61201 ccagtccctg cattcatgcc ctggcatttg tcttgcactc ctacagtgat ggggagctca 61261 cccctgatct gctgtgagtg tgcaccccac actcctgcga actagaatct tcttccttag 61321 accttagtag tttggtttgg ttttgttttg ttttttccta gttctgccct tagcagccat 61381 agagaagaga agtgggaaga gaagggagag acctgccagg ctcacacctg taatcctaac 61441 attttgggag gccaaggtgg gagggtccct tgaagccaag agtttgagac cagtctgtgc 61501 gacatggcaa aaccccatgt ctacaaaaaa atacaaaatt tagctgggcg tgctggtgca 61561 tacctggagc cccagctact tgagaggctg aggtgggagg atggctggag cccgggaggc 61621 agaggatgca gtgagccaag atcaagccac tgcactccag cagtctggca atagagcccg 61681 actttgtctc agattaaaaa aaaaaaagaa gaagaagaag ggcgagaccg tttattgttc 61741 atcttctgcc cgtggcctcc ctgcctgcac tgactcgtgg aatcctcaca gcggcctcta 61801 cccctagggt ggacttcagc agttttactg acgggaaaac tgaggctcaa agatgtttcc 61861 tctgtcacct ccatgatgtg taaacatctg tgaccacagt ttccttttcc tatccctgtc 61921 tagccttctc tgggccaagg ctctcccagg tcattgacct ggccatccag gaaacagccc 61981 agcgtgtccc ctggctacat ctcactccag ggctgcttgc ccttctcaaa ccctgaggca 62041 ttcctaagcc ttccagggac gctgggcttg tatccgtgtg gagctggaag cctgcgggct 62101 cctcactgcc ttccaccagc cctgccccag cttccaggtc ccactgacca cccttctccc 62161 tcgtaggttc aggctcttcg ggcccagctg gaggcgtggc gtctccaagg ggaggctcct 62221 cagagtgcac tgagatccca ggaggatggc cacatccccc cgggctacat ctcacaggta 62281 aggccggggg gctgtttttc agggggaggg ggcagatttc tgcttgccgt gttatcagga 62341 aacagctgag attttgggag cccttcctgt gtgtgctgga acctgtgtgg ggcatttgac 62401 atgcgtcatc tcatttactc tccccacagc tggtgggcgt gatcactgtg cccgttttac 62461 agacaaggcc actgagctct gagaggttat gtgacttgcc caaggtcacc ccgcctgcag 62521 gtctcaaagg tgggatttga gcgagggtcc ggctgactgc agagcctgtg tgtgagtccc 62581 cgtgtgacac tctgcacttg gacccttgcc ccggggaagt ggggggctag tggccccgag 62641 agtcactccc tgaacacagg gaaatcctgc cgaggcccac tgggccaagg ccccacacaa 62701 ggaggtctgc aggacagggg agcctccagt agccctcaga gaatgcaccg tccgcctagg 62761 acagcggttc tcaacggggt ccattttgtc ccccttgggg acatttggct gtgtctggga 62821 atacttctgg ttgtcacaac taggacaaac taactctcta gaaaaaacgt gtgtgtgtac 62881 acatatataa gtttattata aattttacca ataaaaacaa tgcttagtac acaatttaca 62941 aataaaaata tataatttta ttgtgaattc cgtacagcaa atggattttt ctcagaatgc 63001 tttcagtgat tttttccata ctcttgtatc cacaactgat taacaaaggg ggttgttcta 63061 acgtgtgctg gttgacattt ttgtttatgg taatgagtaa gatgagaaga catttgtcga 63121 aactttactg gtccatgttg tcagctactt ctttgctaga tcggatagta gttttctatt 63181 gagaatattt gagaatattc tattaagaat atttttgcaa ttttttgttc tatttacaat 63241 gtaatggtta tagatgtgag atacttctaa gtttaatctg cattattagc attttcttat 63301 cacttgctta agtctagaca atcaacaaaa caataaatca agccctgatg tgtaatgttt 63361 accaattctg cagtgtaaat actcccgctg tggccaatgc tgcattacca gcacaaagtc 63421 cctggacaga gagttgggaa gagatgtcac actattcact aggatttcca ccatgcggat 63481 acagtagatg tgattggccc caagagcacg cataatacaa cacagtgaaa tatttaggaa 63541 gtaataaatt tgagtatcta ttgccttgtc tttaacatag ttaatttaaa gtatataaat 63601 ttaattgtta atggctgtgc ttaacaacta catcacagaa ttactaaaaa tttgacaatc 63661 agctgtctgt agttatcaca ccattatcta aagtagaaaa gaaggggcca ggcgcagtgg 63721 ctcacgcctg taatcccagc actttgggga ggccgaagtg ggcagatcac gaggtcagga 63781 gaacgagact aacctggcca acatggtgaa actccgtctc taataaaata caaaaaatag 63841 ccgggcgtgg tggtgcgcac tgtagtccca gctacttggg aggctgaggc aggggaccca 63901 ctggaaccca ggaggcgcag gttgcagtga gccgagattg cgccacggca ctccagcctg 63961 gcgacagagt aagactccat ctcaaaaaaa aaaaaaaaga aagaaaagaa aagaaggctg 64021 agatctaggc cctaggcagg aggagccttc taaaaatttc caaggggagg tcacgtcatg 64081 agggggctct caggaaggca ttggctgggg catgagaagg aaggctggtt ggtgcgtatt 64141 gtggatgcct ccagtgctga gctaatagtt agaagctctg gcctggtacg gtggctaatg 64201 cctgtatctc agcactttgg gaggtgaggt gggtggatca cttgaggtca aatgttcgag 64261 gccagtgtgg ccagagtggt gaaaccctgt ctctactaaa aaaaaaaaat acaaaactta 64321 gcagggcatg gtggtgggcg cctataatcc cagctactcc agtggctgag gcaggagaat 64381 cgcttgaacc cgggaggcag aggttgcagt gagctgagat cctgccactg cagcctgggt 64441 gacagtgaga ctctatctaa aaacagcaac aaaaaacaaa acaaacaaaa aaagagaagc 64501 tcattccaca gacttttgga ggtttggggt cagacagtga catcaggaaa gtgatgttgg 64561 agtggagggg gcttgggaga gggccaggtg taaggcatta ggaaatggct gaaggagggt 64621 gaatgtcaag ggtctggagg gaggagaatt tgggactgga tgaccagatc tacggaaggc 64681 agaggggcct ttgggggccc tgaggctggg gctgctgctc cagggaagcc cggagaccgt 64741 cctggggcca agtagtggat ggagtttcca ctgatagagg agcaggcagg ggaattgggg 64801 tgggacgcag agggtgaggc tgggggctta ccttgtcctg gggaggggca ggggaggagc 64861 cagtgttgtg ccctgtagcc tcccaccctg aggcagagaa gggagctggg ggcccaacac 64921 cccagctgag gcaggtggga gggcctccga ggcccccagc cagggggctt ctgcctgcgt 64981 gctctgctct aagaagctgc aggggctgct ttctgggtgg gtggggctgg gacccattcg 65041 tacccaccta taatcagagt ggcttcatct tcctccattt tattttattt taattttttt 65101 agagatgagg tcttttactg tcacccaggc tacagtgcag tggcacagag gctcactgca 65161 gcctcgaact ctagggctca agcagtcttc ccacctcagc ctcctgagta ggaaccacag 65221 gctacaccac catgcctggc taattaaaaa aatttttttg tagagacaag gtctcactat 65281 gttccctggg ctggtcttga actcctgggc tcaagtgctt ctctcatgtt ggcctcccaa 65341 agtgctgggg gtacaagtgt gaccactgca ctggcccacc tttgtccgtt ttactcatag 65401 agccagcttt agatttcctt tagataaagg ctctgccact acaatgacgt ttaaaaggca 65461 ctgctttggc ttctcagctt actggtggca aaactgaggc ccacagaagg gtgtgacctt 65521 tgagctatag gcagacctgt gtctggagtt caggcggtct ggtccccagg tgccccattg 65581 ggtgcaccaa agtctgtcag tgtttggtcc cgttagggtg ggatgggcac ggggagcagg 65641 tgggagggga gaagggaata actggggagc agagctgaag accaggcagg tggaggagtg 65701 accccagatg cggaaggcag cagagaagaa gagctgagtc atctgtatcg ccctcaggca 65761 cgggaggagg cggatggaaa ttcggtggac ctggaggagt gacagctggg agggattccc 65821 cagctggtat ctcgggctga gtgggtgccc ttccttcagg ggttgggggc ttgctgctgc 65881 acgacagctg tcgggtggtc tggggcttca cccactggac atctggtaaa gagaaccttt 65941 ccccactatt gcagtgggga cagaggcatt tctttatcta ctttgatgtc catgtcaaag 66001 gtggcagcca ggatcaggac accttgggcc actcaggaag gtaggtgaga gaggccctag 66061 gagcccctgt tcgtcagctg agtcccacct cctgatgtca gcccctgcac ccctgagctg 66121 ctgggtctgc ctgcctggtc tggccctctt cagaagagca gtgcccaccc ccacattgct 66181 gggctcccca ctggtggatg ctggcgtacc gtctccctct gtgcacaggg ttcccgtgcc 66241 cagggagcct cgggggctgg tcctgtgagg cctgctttac ggatgccaag actgaagctc 66301 agagggggcg aggggtttgt tcaggttcac tccaaggcgc agccagggtg aagaccgcct 66361 ctgaggtcca aagtcatgtt ctgttgtcct aagccaggag acacatagag ggcaggaaca 66421 gaagccaggg gacagacacc cctgtcgcca catgaagctc ttggccctcg ctcctccatc 66481 aaatcgtccc caggtgtggc tgctggagag gcggggaggt ggcctttgcg tgggggagac 66541 agtccctcat ctggtcctct gtgccttagt ttcttccctg gctcttcttc cccttccctt 66601 tttaatgacc ttaaacattt ttttaattat ataaaagaaa tgtttacatt ttcaaaaata 66661 atttaaacaa attgaaaggc tggaaatcaa caccctcaca ctccttctgc tgccagctgc 66721 caccccaggg tcctgtcggt ggctgctgcc gcctgcctat cagtttctgg tggcagctgt 66781 aacctgtaac cacagctacc taaataatgc acatgtatta cctcacgctt ctgtaggcga 66841 gaagtctaac gcgagtcttg ccgcgctgca gccaaggcgt gggcaggact gtgttcctct 66901 gcaggcaccc gttgtatccc ttgcctgctc cagcttctgg tggccgtccg cgtcccttgg 66961 ctctcggccc cttccttcat cttcaaagcc tgcagagggg aagtcgagtc cttctcctgc 67021 cacgtcactc tgaccatccc ttcctggtca cacctccctt gaactcttcg cttctgcccc 67081 cttcgtccac ttttaaggac ccttgtgatt acactgggct tgagggataa tctgggataa 67141 tctcccgatt ttaaggtcag ctgattagca accttgattc cctctgcagc ctgaattcct 67201 ctttgccatg taacatgatg tagtcacaga tcctgggagt aagatgtgga caactttgag 67261 gggctatcat tctgccccct acaatatcct ccctaccttt tctgtgtttt ctgtgttttc 67321 cattcactgg gacggacagg tctgcacgtt tgttcccgtg agtgagatca taccacgtgt 67381 atgtcagaag ccaactttca ccacctcatt ttgggatctt tttccacagc atccacacaa 67441 aaactctgtc tagcagctgc ctgtgtccca ttgtcaagct cgatcccatc atttattcaa 67501 gagttcccct gatagggatt tagattgttt ccagttttca tctgttacca acctggctgt 67561 agggaatacc cttgttccaa aagtctctgt acacatacga ctttctgtgg gatcatttct 67621 gggagtgaac ctactaggtc aaccagtggg gtcgcaaaat gtgatgatgc caccggacca 67681 cccccaacac acaccgttgt ggcggacact cccagcagtg ggtattatta gtctgagata 67741 cttgcccatc ttgtctacta agcattattt tgtattacat catcagtttc agctcattta 67801 ctgagcacct gccacatgtc aggccctggc ctagaccctg gggactgcgc cagtcagatg 67861 ttctcagtct tcagggaatt tatggtttgg cagaggtaga accttttgag gcaggggaga 67921 ggctgcccag agacagagct aggagagaca tttaaactgg gctgcaggtc agtaaattac 67981 ccagggaggt aaagttgcca aaaaaacatt ccaggccggg cacagtggct catgcctgta 68041 atcccagcat tttgggaggc caaggccggc agatcacaag gtcagaagtt caagaccatc 68101 ctggctaaca cagtgaaacc ccatctctac taaaaataca aaaattagct gggcgtggtg 68161 gtgggcacct gtagtcccag ctactcacga ggctgaggca gaagaatcac ttgaacccag 68221 aggtggaggt tgcagtgagc tgagattgct ccactgcact ccagcctggg tgacagaaca 68281 aaactctgtc tcaaaaacaa aaacaaaaac aaaaaaacca caaaattcca ggcagtggga 68341 atagctaaag ctcagaggtg tgaacgtgct gcaaccgtaa ctgtgagatt gcttggcaga 68401 gaaaggccag ggatgagaac gtaaaggtca gccatgggaa cggggacttg actctgtagg 68461 acgaggaatc cctggagggc ttgaggcagg agcgacaagg tgaggtttgt gaatgaggag 68521 ccgtggggtg ggggtgggag caggagcagg tgcagactgg aggtgctggg acccaggagg 68581 aggtggtgta cctgcccctg agccttctcc tctggaggct ggggaagggc cgctgtccag 68641 aggaacgggg cagcctgtga caccctggcg tccggcccac aggaggcatg tgagcgcagc 68701 ctggcagaga tggagtcctc gcaccagcag gtgatggagg agctgcagcg gcaccacgag 68761 cgggagctgc agcgcctgca gcaggagaag gagtggctcc tggctgagga gacggcagcc 68821 acggcctcag gtatggaccc tggggggggc acagtgggct gggctctgag cctctgtgct 68881 gaggttcctc ctagccaaac tggggaggat tttatcaaat aagatgtagg ggtctcagtg 68941 ccacatttgg ggtaaagggt cagcaggtgt tagaagctcc aagaactggc ctgtagccct 69001 acttaaaaag ggaaactgag gcagtaaaag ataccctccc cacccccaac accaccacta 69061 ccataggtgg tgactcttcc tgctcagggg cctgcagcca ccatagagtc tgcctaaagg 69121 cacatgctac ccacgtgcgt gggggagagg ctgatcagct gcatcccctg tcctcatagg 69181 agtgcctcct ccctgggcac atgggccaga ccctggggag agcaggggaa ggtgtgagca 69241 ttgtccatgc cagctgtgtg ccaggcactg ggccccacat gtttcccaca ggagcaccct 69301 tcatcctgga caattccctc ccctcctgcc accgcacacc tgctgtgtgc ctggcacatt 69361 cctaggcatc actaggggtt tgcagaacaa tagaaatgct ggccaatgtc acatgatctg 69421 aagctcacaa cctgccagtg ctgtgccaag tgctcatgca ctcgaaccca gccttggggc 69481 cagtgtgctc tgcatttcag gaagatcgcc tttgcagccg cgtgtgttag agaccccttc 69541 cccctcagca gagtctggac ttcgccctgt aatctggcac taaggtttct gctgtgaaat 69601 ggataaaaat cacacttaag tggaataata aagaccataa atagcctcat gtccgttcag 69661 ggtggggatt gccaccaaaa gatttaccag aggcccggtg cagtggctca tgcctgtaat 69721 cccagcactt tgggaggctg aggcgggcag atcacctgag gtcaggagtt cgagactagc 69781 ctggccaaca tggtgaaacc ccatctctac taaaaataca aaaattagct gggcgtgatg 69841 gtgggcagct gcaatcccag ctactcagga ggctaaggca ggagaatctc ttgaacccag 69901 gagacagagg ctgcagtgag ctgagattgc accactgcac tccagcctgg atgacagagt 69961 aagactccat caaaaaaaaa aaaggccagg cactgtggct catgcctgta atcccagcac 70021 tttgggaggc cgaggcaggt gcatcacgag gtcaggagtt caagaccagc ctggccaaga 70081 tggtgaaacc ctgtctctac tatgaataca aaaattagcc atgcgcggtg gcaggcgcgt 70141 gtaatcccag ctactcagga ggctgaggca ggagaatcgc ttgaaagtgg gcggcaaagg 70201 ttgtagtgaa ccaagattgt gccactgcac tccagcctgg gtgacagagt gagactccgt 70261 ctcctgggtg acagagtgag actccgtctc ctgggtgaca gagtgagact ctgtctcaaa 70321 aaaaaaaaga aagaaaaaaa ggagagaaac tttcaatgtt cagaagtttc ggattttaga 70381 attgtgggta aaaccatggg tggccctgag tgggaaaaaa aaagcctcgg tctcagtcct 70441 taggagctca caatctgaga ataaagccag caggagctaa tgttggggca tttactctga 70501 gccatgcttt gttctaaatt cttcacacac cttccaataa ccccatggag gaaaggtact 70561 gttgttatcg atccctgttt tccagataag ggatctgagg cacaaggggt taagtcacct 70621 gtgcaaagtc acatcggttt atgctgactg tggagcctga gctcttgacc acgaggctgg 70681 tcaaagcaga taggccttgt ttgagagccc tcagagtctg cagggggggt gtactaggtg 70741 gggtcctacc tggaaatcac tagaacagga ggtaccaatg gtcagaccct gagctgtctc 70801 cccagtaggg tccatccaac aggattatct tcccttaata gatgggctga gagaggttga 70861 gagcttaccc caagccactc agtttatgac acaacctggg ctactctaga ctcctggttc 70921 ggtgctcttt gcatagcact ccttggtcca agtccatagt acttgcatag tactatgtgg 70981 agtccacata gtactccacc agtacatgtg gcgtctcaga gctggtggca cttggtgctg 71041 ctgacccccc tccagtctct cttgtgcctc tctgccctgc ttccagccat tgaagccatg 71101 aagaaggcct accaggaaga gctgagccga gagctgagca aaacacggag tctccagcag 71161 ggcccggatg gcctccggaa gcagcaccag taagatgatg ccggggccca actgcccacc 71221 ctgatggtta tgggttgagg aactttgctg aggccccttg gcagcggaca catcagtttg 71281 cccctagctg agattcctgc tccagtctca tggatgcaag aaacagaagc agaaggtcct 71341 caggcagacc ccatgccagt cctcacagac agtccttcag gcagcttctt gtcttggctg 71401 gtcccagcct ccacccacct cttcacccct ttagtctccc ctggagctgg gctgcagtgt 71461 cactgttgac cactaggcct ctccctgccc cagagcacag ttttggaatg ttgaggtttc 71521 aggggcttta actttaaaga tgggcccctc cagccgggca cattggctca tgcctgtaat 71581 cccagcactt tgggaggctg ggatcaggag ttcgagacta gcctggccaa catggtgaaa 71641 ccccatctct actaaaaata caagctagct gaatgtggtg gcgggagcct gcaattctag 71701 ctacttggga ggctgaggca ggagaatcgc ttgaacccag gaggcagagg ttgcagtgag 71761 ccaagattgt gccattgtat tccagcctgg gcaacaagag tgagagcaag actccatcta 71821 aaaaaaaaaa aaaagatggg ctcctccaag ccaccctcac ttagggtaaa cacctgtagc 71881 ccagagaagc tgtcactggt tcacagcccc acagcaggct aaaggcaaac ctagagaggg 71941 aaccccagag tcctgggatg ctttaagtct acctgactgg actccaggct tggcaggagc 72001 aagacaacct atgctctcct ctgctcctcc tctggggcag gtcagatgtg gaggcactga 72061 agcgagagct gcaggtgcta tcggagcagt actcgcagaa gtgcctggag attggggcac 72121 tcatgcggca ggctgaggag cgcgagcaca cgctgcgccg ctgccagcag gagggccagg 72181 agctgctgcg ccacaaccag gtgggcctgg ccccaggttg gggggacacg ggtgggtccc 72241 ggcacccctc ccctgaccac cgtgcctctc ccaggagctg catggccgcc tgtcagagga 72301 gatagaccag ctgcgcggct tcattgcctc gcagggcatg ggcaatggct gcgggcgcag 72361 caacgagcgg agttcctgcg agctagaggt gagtgtcctc actagcacca ggcagcccag 72421 tggttctcgg ggcccggggc tatggggcac ccccgccata ggctgggtat cacctgtggc 72481 aggaaagcca agtctcccag tggctgggcc agcctgacta ggctagaaca cctactgtgc 72541 atccagtagc cagcattctg ccctcccacc tgcattgtgt cacctacctg ccgtgtacca 72601 tagcaaatca ctccactttt ctgagtccca gtagctcatc tgtaaaatgg caccagcacc 72661 ttccttactg ggaaatattg gggtaagaaa atatgtgtgt atgtgtgtga tgccagtatc 72721 actgtagtat tttctttctt tttctttctt tctttttttg agacagagtc tctctctgtc 72781 acccaggctg gagtgtagtg acacgatctc agttcactgc aacctctgcc tccctggttc 72841 aagcgattct cctgcctcag cctcccaagt agctaggatt acaggcctgc accaccacac 72901 ccagctaatt ttttatattt ttggtagaga caagtttcac tatgttggcc aggctggtct 72961 cgaactccgg acctcaagtg atctgcctac cttggcctca caaagtgctg ggattacagc 73021 atgagccacc acacccggcc ttagtattta tttctttact tttttttttt ttttgagaca 73081 gagttttgct gttgttgccc aggctacagt gcagtggcgc gatctcggct caccacaacc 73141 tccgcctccc aggttaaaac gattctcctg gccgggcgcg gtggctcacg cctgtaatcc 73201 cagcactttg ggaggccgag gcgggcagat cacgaggtag gagatcaaga ccatcctggc 73261 taacacagtg aaaccccgtc tctactaaaa atacaaaaaa attacccggg cgtggtggcg 73321 ggcgcggtgg cgggtgcctg tagtcccagc cactccggag gctgaggcag gagaatggca 73381 tgaacctggg aggcggagcg tgcagtgagc cgagatcgtg ccactgcact ccagcctggg 73441 tgacagagcg agactccgtc tcaaaaaaaa aaaaaatatt aaaaaaaaaa agcgattatc 73501 ctgcctcagc ctcccaagta gctaggatta caggcatgtg ccacctcgcc tggataattt 73561 tgtattttta gtagagacag ggtttttcca tgttggtcag gctcttctcg aactcccaac 73621 ctcaggtgat ccgcccactt cggcctctca aagtgttggg attacaggcg tgagccaccg 73681 tgcccagccg atattttatt tctctttttt tttttgagac ggagtcactc tgtcacccag 73741 gctggagtgc agtggcacca tctcggctca ctgcaagctc cgcctctcgg gttcatgcca 73801 ttctcctgcc tcagcctccc gagtagctgg gactacaggc acccgccacc acacctggct 73861 aattttttgt atttttagta gagacggggt ttcaccatgt tagccgggat ggtcccaatc 73921 tcctgacctc gtgatccgcc cgcctctgcc tcccaaagtg ctgggattac aggcgtgagc 73981 caccgctcct ggccccaata ttttatttct tcaacaaaca cttaggtgag gctcactctg 74041 tacctagaaa ttctggaagc cctttttgtc tgttaactca tctaatcttc ctgacagctc 74101 catacattag ctactatgac tgtccccatt tacagatgag gaaactgagg cacaggaagg 74161 tcaagtacct taccaaagct tttatagctg gactgggatt tgaaccaggc agtctggctc 74221 cagtctgagc ttttaagcct ccccagtcct ggctgaactt gtttcctcct tggtcaagtc 74281 agcagcacct agccctcggg gttggggagg ggttaatgag gtgccttgtg gagtggttca 74341 gcctgctcag gtttatgtag ggcttctttt catccatctc actcccgagg tgagagcctg 74401 gtgctgcatg agggctgcag cagacttgac cgtgagatat ccactcacac gggctggaca 74461 ggggtgagag taagggaagg caaagcaggg gaatcggaga gggcttcctg gaggagtccg 74521 cctccaggat gtagagggtt tttgtgcaga taggggctgc attctagggg cctgaggcag 74581 agagaacccg ggctgcaggg cactatgggc cagggtagct ctggcttctg gccctgggtc 74641 agtccagcac ctatatcccc aggtgctgct tcgcgtaaaa gaaaacgaac tccagtacct 74701 aaagaaggag gtgcagtgcc tccgggacga gctccagatg atgcagaagg taggtccttc 74761 cgctgggctg ggggccgtcg gggactctgg agccatctgg atgccatcct gtgagcacct 74821 gctctgtgcc aagccctcca ctcgcttcat ccttcctcag gctctcctgt gcttctccca 74881 tgtaggtgtc atcatcccca ttcactgaca gggaaactga gactaagaaa ggggaagtga 74941 cttccccaag gctgtacttg gcttctgttt atttagcatt atttaattta ttgattatta 75001 ttgagcacct actatatcct gggcactgtg ctaggtgctg ggaagacaga tgtgaacaaa 75061 ataaccccaa atctctgctg tggggagctt gcactccagt gagaataacc acgttgctag 75121 gagttgggtg ggtcagggtt cagcccaggt ctgagtctgc agcccgcctg gcccaccctt 75181 ggctgctatg tcactgcctg gtgcgctctg tcagtttggg gcaggaagtg gacatgttgg 75241 tggctctgta agtgcacgtg agccagaccg tgtttaccgc acttgaagaa caggtggcgt 75301 gaactcacag gaagggcccg agcacccagc caggctgacc tggttctcat cccagccact 75361 cactgccctg cggtcttggt caaaatcttc tcccccgaaa caggatgagg atgacaatga 75421 cgcctgtgtc cctgggtggt accagggagg tgggaggggt aagcccagaa cccacggcca 75481 tcttggggag ccacctggag ggatgaagcg aggtatctgc ggggaggtct ggctgctggt 75541 gctgcccatg tgcccggttg gcagggctgg agggagagac ttcatgccct catacctgcc 75601 tcctgccccc caggacaagc gcttcacctc gggaaagtac caggacgtct atgtggagct 75661 gagccacatc aagacacggt ctgagcggga gatcgagcag ctgaaggagc acctgcgtct 75721 tgccatggcc gccctccagg agaaggagtc gatgcgcaac agcctggctg agtagaggtg 75781 gatgccgagg cgtgtgccct gcagggtggg caggggctga ggctctccca cacccgggac 75841 tccctggacc accccagcca ggccacttcc ttcttctggc ctccaattcc cgttctgtaa 75901 aaaggacaat gaaaccagca acacggggtt gttgcagaga tcccatcaga cccgggccac 75961 aggctgcttc atcagcttaa gcctgttcct ccagagctgg gcggcacagt gcagagccac 76021 agcctactca gtgcaccccc cttcttgggg ctggaggcaa atgcagcgtg cacatccctg 76081 acccccacag tgaatctcca ctgagcttca cacacacaca tcgcacgctg aggccgggct 76141 tctatcccag ttagtcttaa cactccttct tgacttagca gggctcaaag tggttggttg 76201 gttggttggt tggttggttg gttggttggt tggttggttt tggttgcttt gagaaaggtc 76261 ttactctgac acccaggctg gagtgcagtg gtgcaatcac ggctcactgc agcctcaacc 76321 tcctaggctc aagggatcct cccacctcag ccttctgagt agctgggacc acaggccctc 76381 accaccatgc ccagataatt tttgcacttt ttgtataggt ggggtttcgc cgtgatttcc 76441 caggctggtc tcgaactcct gggctcaagc aatacacctg cctcagcctc ccaaaattct 76501 gagattacag gtgtgagccg ctgcacctgg ccaaagtgtt cttatttttg ctttttcaac 76561 gccacatcta cctggagcat cctctttctg ataagtcctc atggacttcc tatggcatgc 76621 aggagaggcc accctatggc tgagctgctt gggaaggagc caggaagagc ggatctggct 76681 gtaccttagg ggctgagagg tggtggaagg acccactcag cacccttgct tggccttggg 76741 gtggcctcgc agcccctcag cccaggcctc agccctgccg caccttgtct ttcaggtccc 76801 gcccagctgc agaccctcca ggctggagga ccagccgccc tccttccctc ctggatggaa 76861 gtaaaaagcc aagctttctc cccaccctct gtgggccaca cgtgcacttg cacccaccac 76921 acacacacac acacacacac acacacacac agacacacag acacatacgc acacacgtgc 76981 acacatgtac acacggatac acacacacac acacacactg catatctgag cgcgcccctc 77041 gcactgggtc tcaccttgca ccttcttcag gattttatat gtgaagagat ttttatatag 77101 atttttttcc tttttttcca aaacacttta tactttaaaa aaaaaaaaaa aaagcaattc 77161 ctggtggctg tgtgcctcca accctggtcc ccctctgtct ccagccaccc tctgcttggg 77221 cttctgagct ggtggccctg gcccagaggt ctggcggagg cccaggcagc agccatggcg 77281 gggtgtctct acaggggaga ggcgggagcc tgccaccctc ttcctgccct acctcctact 77341 aacacttcct gccccatttg gacccgtacc atggggctca ggacagaggg agctagcagc 77401 tggcctccat ggccccacag cctccttcga ggctgtgctg ggtgcagaac cgccagagcc 77461 acccaaaagg tgtttctctt ctgctccctg aacctcttaa cttaataaaa cgttccagca 77521 gctctggtgt cctagatggc tggcagaaca ggaatggaga ttggggtttc ttgaagtggc 77581 ttccccactc acaccctacc cacaccccac ccttcctaaa gcagcggcct ctaggcttct 77641 gagggtgggg ctgaaaatcc aaggtctccc ttagtacaga ctgtgacgcc cccagtgtgg 77701 cttgcaggct agtggcagcg gaagcatgtg ggaaatagca agtccagtcc caccccaacc 77761 tactgaacca gcgtctgcat tttaacaggg tgccccagtg attcacgtga ccttcaaagt 77821 ctgaggagcc ctggagtagg gcccagggcc caggcctgag agagaggcct ggggctaaga 77881 ctagccctga ccatgacctt gggcaagtca cacccctcac tgagcctcag tttgcttctc 77941 catcaaatgg gtgtttttct ttcagtccca gtcctctcct gaggcttttc ccagaggtca 78001 tgcccagccc tgggcagggg tgagggcagg gttgtggctg ccaggcacag gtccagcggg 78061 ctgggagtcc tcaccatggc tggctgtgct gattatggtt gcatggggct gggaagaggt 78121 cccatttctg agccacagaa acaggccaca tccagtaggg gtcctggaag gctgtgagaa 78181 cccagaggag accctgaccc agcctgcagg tagaagactg cctttggagg cagctttgaa 78241 agatgactct tccagatgga agaatcagga agggccttcc cacgtggagg caccagcagg 78301 agcaaacgtc cctggtgtgt tcaggcaaag agccacagga gagtgacctc gtggagtggg 78361 aagagattgt ttcccattcc cttgccaggg attggttgag gaatggacaa ggcttgcagt 78421 tcacgcaagc cagtgaaatg cgaggggaag tcttgggagt ggggtggagg aggtcatctg 78481 ggaagggtgt ccttggtctt aaaaagaggc acaagaggcc gggcgcggtg gctcttgcct 78541 attatcctag cactttggga ggccaaggca gggggatcac ttgaggtcag gagttcgaga 78601 ccagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccagac 78661 gtggtgccaa gcacctgtaa tcccagctac tcaggaggct gaggcaggag aatcacttga 78721 acccaggagg cagaagttgc agtgagccaa gatcgcgcca ctgcactcca gcctgtgtga 78781 caagggcgaa actccatctc aaaaaaaaag ggggagggtg gcgcaaggag aggacacctc 78841 tctcctggcc ctgtcgccat cttccctcat caatagctaa aaatggcaaa gaagaaagag 78901 ccaggacccc gtgccatcaa atcctccggc cttgtgctgc cctgtctcgg cactgcttgc 78961 cttaggagat caggagtgtt cctagccact gggagatggg atgcctgcca ctggcagctc 79021 tgccgtccat cctcaccatc ccaccgtccc cccaagacag ctctccatcc catcctctgc 79081 ctcccttcta gcctcaacct aactcagggc tcccccgtct cacacctggg ttgcaggaac 79141 atcctcttca ccaacccccc tcccatccct cctcagggct gcctagggca gctacaaaaa 79201 ccaggccagc ctctgaaagg tgctccacat ctcattaaaa accgtgaaat cgcactgccc 79261 cactatcaga atagctcaga ggagaaggtc tgccagtacc aagtgctggt ggggatacgg 79321 agaagagcag ctcccaggcg ctgctggtgc aaatgtgctt tgttgcaccc acggcaggaa 79381 actgaccagc ttctcatcaa gttaaatacg catctaccct atggcctagc atttccactc 79441 ttgcttacac atccaggaga aatgagtcct tacatgcaca aaaggatgag taccgtaata 79501 ctcacatcag caaataaaca atacagctgt gtgtcagtag tagaatgaat aaattgtggt 79561 cgattcata

Stereocilin

[0148] The STRC gene encodes stereocilin, a protein that is normally expressed in the inner ear and is associated with the stereocilia of specialized hair cells in the inner ear (see, e.g., Verpy et al., Nature 456: 255-258, 2008; and Zhang et al., J. Med. Genet. 44: 233-240, 2007). Stereocilia, which are about 10-50 μm in length, are important for hearing and balance. Stereocilia play a mechanosensing role in hearing. By bending in response to sound, they form a structure for mechanoreception of sound stimulation.

[0149] The human STRC gene is located on chromosome 15q15. It contains 29 exons encompassing ˜19 kilobases (kb) (Verpy et al., Nature Genetics 29(3): 345-349, 2001; NCBI Accession No. NG011636.1). The gene is tandemly duplicated on chromosome 15q15 in a telomere-to-centromere orientation, with the tandem copies located less than 100 kb apart on the chromosome. The coding sequence of the second copy is interrupted by a stop codon in exon 20, meaning that it is a “pseudogene” that encodes a nonfunctional truncated protein. (Hereinafter, references to “the STRC gene” mean the gene that does not have that stop codon in exon 20, while references to the “pseudogene” or the “STRC pseudogene” denote the gene that does have that stop codon in exon 20.) In some examples, the full-length STRC protein is a full-length wildtype STRC protein. The full-length wildtype STRC protein expressed from the human STRC gene is 1775 residues in length, and contains a signal peptide and several hydrophobic segments. When the signal peptide is cleaved off during processing of the wildtype protein, the resulting mature wildtype stereocilin protein is 1719 residues in length. In some embodiments, a full-length STRC protein can include a heterologous signal peptide positioned N-terminal to an amino acid sequence of a mature wildtype stereocilin protein.

[0150] Various mutations in the STRC gene have been associated with hearing loss (e.g., non-symptomatic sensorineural hearing loss). For example, a homozygous 1-bp insertion was identified in exon 13 in a consanguineous Pakistani family with autosomal recessive non-syndromic sensorineural deafness-16 (DFNB16) (Verpy et al. (2001). Another example found in a family with DFNB16 includes both a 4-bp deletion in exon 5 and a larger deletion encompassing exons 17-29. The two deletions were inherited from the father and mother, respectively. The 4-bp deletion was predicted to result in the translation of 5 out-of-frame amino acids and a premature stop codon in exon 5.

[0151] Additional exemplary mutations in a stereocilin gene detected in subjects having non-symptomatic sensorineural hearing loss and methods of sequencing a nucleic acid encoding stereocilin are described in, e.g., Verpy et al., Nature 456:255-259, 2008; Verpy et al., Res. Systems Neurosci. 519:194-210, 2011; Hofrichter et al., Clinical Genetics 87:49-55, 2015; and Mandelker et al., J. Mol. Diagnostics 16:639-647, 2014. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

[0152] An exemplary human wildtype stereocilin protein is or includes the sequence of SEQ ID NO: 34. Non-limiting examples of nucleic acid encoding a wildtype stereocilin protein are or include SEQ ID NO: 35 and SEQ ID NO: 36. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 35 can be codon-optimized to allow for optimal expression in a non-human mammal or in a human.

[0153] In some embodiments of any of the compositions described herein, the STRC protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 34.

TABLE-US-00011 Human Full-length Wildtype Stereocilin Protein (Signal sequence shown in bold) (SEQ ID NO: 34) MALSLWPLLLLLLLLLLLSFAVTLAPTGPHSLDPGLSELKSLLSTLDQAPQGSLSRSRETTFLANISSSFE PGRMGEGPVGEPPPLQPPALRLHDFLVTLRGSPDWEPMLGLLGDMLALLGQEQTPRDFLVHQAGVLGGLVE VLLGALVPGGPPTPTRPPCTRDGPSDCVLAADWLPSLLLLLEGTRWQALVQVQPSVDPTNATGLDGREAAP HFLQGLLGLLTPTGELGSKEALWGGLLRTVGAPLYAAFQEGLLRVTHSLQDEVFSILGQPEPDTNGQCQGV FFLTLSLLGNLQQLLLWGVRHNLSWDVQALGFLSGSPPPPPALLHCLSTGVPLPRASQPSAHISPRQRRAI TVEALCENHLGPAPPYSISNFSIHLLCQHTKPATPQPHPSTTAICQTAVWYAVSWAPGAQGWLQACHDQFP DEFLDAICSNLSFSALSGSNRRLVKRLCAGLLPPPTSCPEGLPPVPLTPDIFWGCFLENETLWAERLCGEA SLQAVPPSNQAWVQHVCQGPTPDVTASPPCHIGPCGERCPDGGSFLVMVCANDTMYEVLVPFWPWLAGQCR ISRGGNDTCFLEGLLGPLLPSLPPLGPSPLCLTPGPFLLGMLSQLPRCQSSVPALAHPTRLHYLLRLLTFL LGPGAGGAEAQGMLGRALLLSSLPDNCSFWDAFRPEGRRSVLRTIGEYLEQDEEQPTPSGFEPTVNPSSGI SKMELLACFSPVLWDLLQREKSVWALQILVQAYLHMPPENLQQLVLSAEREAAQGFLTLMLQGKLQGKLQV PPSEEQALGRLTALLLQRYPRLTSQLFIDLSPLIPFLAVSDLMRFPPSLLANDSVQQGYRGSEENSLEEDK GLRPMTPRSLAAIRDYSPGMRPEQKEALAKRLLAPELFGEVPAWPQELLWAVLPLLPHLPLENFLQLSPHQ IQALEDSWPAAGLGPGHARHVLRSLVNQSVQDGEEQVRRLGPLACFLSPEELQSLVPLSDPTGPVERGLLE CAANGTLSPEGRVAYELLGVLRSSGGAVLSPRELRVWAPLFSQLGLRFLQELSEPQLRAMLPVLQGTSVTP AQAVLLLGRLLPRHDLSLEELCSLHLLLPGLSPQTLQAIPRRVLVGACSCLAPELSRLSACQTAALLQTFR VKDGVKNMGTTGAGPAVCIPGQQPIPTTWPDCLLPLLPLKLLQLDSLALLANRRRYWELPWSEQQAQFLWK KMQVPTNLTLRNLQALGTLAGGMSCEFLQQINSMVDFLEVVHMIYQLPTRVRGSLRACIWAELQRRMAMPE PEWTTVGPELNGLDSKLLLDLPIQLMDRLSNESIMLVVELVQRAPEQLLALTPLHQAALAERALQNLAPKE TPVSGEVLETLGPLVGFLGTESTRQIPLQILLSHLSQLQGFCLGETFATELGWLLLQESVLGKPELWSQDE VEQAGRLVFTLSTEATSLIPREALGPETLERLLEKQQSWEQSRVGQLCREPQLAAKKAALVAGVVRPAAED LPEPVPNCADVRGTFPAAWSATQIAEMELSDFEDCLTLFAGDPGLGPEELRAAMGKAKQLWGPPRGFRPEQ ILQLGRLLIGLGDRELQELILVDWGVLSTLGQIDGWSTTQLRIVVSSFLRQSGRHVSHLDFVHLTALGYTL CGLRPEELQHISSWEFSQAALFLGTLHLQCSEEQLEVLAHLLVLPGGFGPISNWGPEIFTEIGTIAAGIPD LALSALLRGQIQGVTPLATSVIPPPKFAVVFSPIQLSSLTSAQAVAVTPEQMAFLSPEQRRAVAWAQHEGK ESPEQQGRSTAWGLQDWSRPSWSLVLTISFLGHLL Human Wildtype Stereocilin cDNA (SEQ ID NO: 35) atggctctcagcctctggccoctgctgctgctgctgctgctgctgctgctgctgtcctttgcagtgactct ggcccctactgggcctcattccctggaccctggtctctccttcctgaagtcattgctctccactctggacc aggctccccagggctccctgagccgctcacggttctttacattcctggccaacatttcttcttcctttgag cctgggagaatgggggaaggaccagtaggagagcccccacctctccagccgcctgctctgcggctccatga ttttctagtgacactgagaggtagccccgactgggagccaatgctagggctgctaggggatatgctggcac tgctgggacaggagcagactccccgagatttcctggtgcaccaggcaggggtgctgggtggacttgtggag gtgctgctgggagccttagttcctgggggcccccctaccccaactcggcccccatgcacccgtgatgggcc gtctgactgtgtcctggctgctgactggttgccttctctgctgctgttgttagagggcacacgctggcaag ctctggtgcaggtgcagcccagtgtggaccccaccaatgccacaggcctcgatgggagggaggcagctcct cactttttgcagggtctgttgggtttgcttaccccaacaggggagctaggctccaaggaggctctttgggg cggtctgctacgcacagtgggggcccccctctatgctgcctttcaggaggggctgctccgtgtcactcact ccctgcaggatgaggtcttctccattttggggcagccagagcctgataccaatgggcagtgccagggagtt ttcttccttactctttccctcctaggtaaccttcaacagctgctcttatggggcgtccggcacaacctttc ctgggatgtccaggcgctgggctttctgtctggatcaccacccccaccccctgccctccttcactgcctga gcacgggcgtgcctctgcccagagcttctcagccgtcagcccacatcagcccacgccaacggcgagccatc actgtggaggccctctgtgagaaccacttaggcccagcaccaccctacagcatttccaacttctccatcca cttgctctgccagcacaccaagcctgccactccacagccccatcccagcaccactgccatctgccagacag ctgtgtggtatgcagtgtcctgggcaccaggtgcccaaggctggctacaggcctgccacgaccagtttcct gatgagtttttggatgcgatctgcagtaacctctccttttcagccctgtctggctccaaccgccgcctggt gaagcggctctgtgctggcctgctcccaccccctaccagctgccctgaaggcctgccccctgttcccctca ccccagacatcttttggggctgcttcttggagaatgagactctgtgggctgagcgactgtgtggggaggca agtctacaggctgtgccccccagcaaccaggcttgggtccagcatgtgtgccagggccccaccccagatgt cactgcctccccaccatgccacattggaccctgtggggaacgctgcccggatgggggcagcttcctggtga tggtctgtgccaatgacaccatgtatgaggtcctggtgcccttctggccttggctagcaggccaatgcagg ataagtcgtgggggcaatgacacttgcttcctagaagggctgctgggcccccttctgccctctctgccacc actgggaccatccccactctgtctgacccctggccccttcctccttggcatgctatcccagttgccacgct gtcagtcctctgtcccagctcttgctcaccccacacgcctacactatctcctccgcctgctgaccttcctc ttgggtccaggggctgggggcgctgaggcccaggggatgctgggtcgggccctactgctctccagtctccc agacaactgctccttctgggatgcctttcgcccagagggccggcgcagtgtgctacggacgattggggaat acctggaacaagatgaggagcagccaaccccatcaggctttgaacccactgtcaaccccagctctggtata agcaagatggagctgctggcctgctttagtcctgtgctgtgggatctgctccagagggaaaagagtgtttg ggccctgcagattctagtgcaggcgtacctgcatatgcccccagaaaacctccagcagctggtgctttcag cagagagggaggctgcacagggcttcctgacactcatgctgcaggggaagctgcaggggaagctgcaggta ccaccatccgaggagcaggccctgggtcgcctgacagccctgctgctccagcggtacccacgcctcacctc ccagctcttcattgacctgtcaccactcatccctttcttggctgtctctgacctgatgcgcttcccaccat ccctgttagccaacgacagtgtacagcagggctacagagggtcagaggaaaacagtttggaggaagacaaa gggttaagacccatgactcctcgcagcctggctgccatccgggattacagcccaggaatgaggcctgaaca gaaggaggctctggcaaagcgactgctggccoctgaactgtttggggaagtgcctgcctggccccaggagc tgctgtgggcagtgctgcccctgctcccccacctccctctggagaactttttgcagctcagccctcaccag atccaggccctggaggatagctggccagcagcaggtctggggccagggcatgcccgccatgtgctgcgcag cctggtaaaccagagtgtccaggatggtgaggagcaggtacgcaggcttgggcccctcgcctgtttcctga gccctgaggagctgcagagcctagtgcccctgagtgatccaacggggccagtagaacgggggctgctggaa tgtgcagccaatgggaccctcagcccagaaggacgggtggcatatgaacttctgggtgtgttgcgctcatc tggaggagcggtgctgagcccccgggagctgcgggtctgggcccctctcttctctcagctgggcctccgct tccttcaggagctgtcagagccccagcttagagccatgcttcctgtcctgcagggaactagtgttacacct gctcaggctgtcctgctgcttggacggctccttcctaggcacgatctatccctggaggaactctgctcctt gcaccttctgctaccaggcctcagcccccagacactccaggccatccctaggcgagtcctggtcggggctt gttcctgcctggcccctgaactgtcacgcctctcagcctgccagaccgcagcactgctgcagacctttcgg gttaaagatggtgttaaaaatatgggtacaacaggtgctggtccagctgtgtgtatccctggtcagcagcc tattcccaccacctggccagactgcctgcttcccctgctcccattaaagctgctacaactggattccttgg ctcttctggcaaatcgaagacgctactgggagctgccctggtctgagcagcaggcacagtttctctggaag aagatgcaagtacccaccaaccttaccctcaggaatctgcaggctctgggcaccctggcaggaggcatgtc ctgtgagtttctgcagcagatcaactccatggtagacttccttgaagtggtgcacatgatctatcagctgc ccactagagttcgagggagcctgagggcctgtatctgggcagagctacagcggaggatggcaatgccagaa ccagaatggacaactgtagggccagaactgaacgggctggatagcaagctactcctggacttaccgatcca gttgatggacagactatccaatgaatccattatgttggtggtggagctggtgcaaagagctccagagcagc tgctggcactgacccccctccaccaggcagccctggcagagagggcactacaaaacctggctccaaaggag actccagtctcaggggaagtgctggagaccttaggccctttggttggattcctggggacagagagcacacg acagatccccctacagatcctgctgtcccatctcagtcagctgcaaggcttctgcctaggagagacatttg ccacagagctgggatggctgctattgcaggagtctgttcttgggaaaccagagttgtggagccaggatgaa gtagagcaagctggacgcctagtattcactctgtctactgaggcaatttccttgatccccagggaggcctt gggtccagagaccctggagcggcttctagaaaagcagcagagctgggagcagagcagagttggacagctgt gtagggagccacagcttgctgccaagaaagcagccctggtagcaggggtggtgcgaccagctgctgaggat cttccagaacctgtgccaaattgtgcagatgtacgagggacattcccagcagcctggtctgcaacccagat tgcagagatggagctctcagactttgaggactgcctgacattatttgcaggagacccaggacttgggcctg aggaactgcgggcagccatgggcaaagcaaaacagttgtggggtcccccccggggatttcgtcctgagcag atcctgcagcttggtaggctcttaataggtctaggagatcgggaactacaggagctgatcctagtggactg gggagtgctgagcaccctggggcagatagatggctggagcaccactcagctccgcattgtggtctccagtt tcctacggcagagtggtcggcatgtgagccacctggacttcgttcatctgacagcgctgggttatactctc tgtggactgcggccagaggagctccagcacatcagcagttgggagttcagccaagcagctctcttcctcgg caccctgcatctccagtgctctgaggaacaactggaggttctggcccacctacttgtactgcctggtgggt ttggcccaatcagtaactgggggcctgagatcttcactgaaattggcaccatagcagctgggatcccagac ctggctctttcagcactgctgcggggacagatccagggcgttactcctcttgccatttctgtcatccctcc tcctaaatttgctgtggtgtttagtcccatccaactatctagtctcaccagtgctcaggctgtggctgtca ctcctgagcaaatggcctttctgagtcctgagcagcgacgagcagttgcatgggcccaacatgagggaaag gagagcccagaacagcaaggtcgaagtacagcctggggcctccaggactggtcacgaccttcctggtccct ggtattgactatcagcttccttggccacctgctatga Human Wildtype Stereocilin cDNA - Codon Optimized (SEQ ID NO: 36) atggctctgtctctgtggcctctgctgctgctcctgttgctgcttctgctgctcagcttcgccgtgacact ggctccaacaggaccccactctctggatcctggcctgagctttctgaagtccctgctgagcaccctggatc aggctcctcagggcagcctgagcagatccagattcttcaccttcctggccaacatcagcagcagcttcgag cctggcagaatgggagaaggacctgtgggagaacctcctccactgcaacctccagctctgcggctgcacga ttttctggtcacactgagaggcagccccgactgggaacctatgctgggactgctgggagatatgctggccc tgctcggacaagagcagacccctagagatttcctggtgcatcaggctggcgtgctcggaggactggttgaa gttctgcttggagcactggtgcctggcggacctcctacacctacaagacctccatgcaccagagatggccc cagcgattgtgtgctggctgctgattggctgcctagcctgctcctgcttctggaaggcacaagatggcagg ccctggtgcaggttcagccttctgtggatcctaccaatgccaccggcctggatggaagagaagccgctcca cactttctgcagggactgcttggactgctcacacctactggcgagctgggctctaaagaagccctttgggg aggcctgctgagaacagttggagcccctctgtacgccgcctttcaagagggactcctgagagtgacacaca gcctgcaggacgaggtgttcagcatcctgggacagccagagcctgacaccaatggacagtgtcagggcgtg ttctttctgaccctgagcctgctgggcaacctgcagcaactgcttctgtggggcgtcagacacaacctgag ctgggatgtgcaggcactgggctttctgtctggaagccctccacctccaccagcactgctgcattgtctgt ctactggcgtgccactgcctagagcctctcagcctagcgctcacatcagccccagacagagaagggccatc accgtggaagctctgtgcgagaatcacctgggacctgctcctccatacagcatcagcaacttctccatcca tctgctgtgtcagcacaccaagcctgccacacctcagcctcatcctagcaccacagccatctgtcagaccg ccgtttggtacgccgtttcttgggctcctggtgctcaaggatggctgcaggcctgtcacgatcagttcccc gacgagttcctggacgccatctgcagcaatctgagcttctctgccctgtccggcagcaatcggagactggt caaaagactgtgcgccggactgctgcctcctccaacatcttgtcctgagggactgcctcctgtgcctctga ctcccgatatcttttggggctgcttcctggaaaacgagacactgtgggccgagagactgtgtggcgaagcc tctctgcaagccgtgcctccatctaatcaggcctgggtgcagcacgtttgtcagggccctacacctgacgt gacagcctctcctccttgtcacatcggaccttgcggcgagagatgtcctgatggcggcagctttctcgtga tggtctgcgccaacgacactatgtacgaggtgctggtgcccttctggccttggctggctggccagtgtaga atctccagaggcggcaacgatacctgtttcctggaaggactcctgggaccactgcttccatctctgcctcc gcttggaccctctcctctgtgtcttacccctggacctttcctgctggggatgctgtctcagctgcctagat gccagtctagcgtgccagctctggcccatccaaccagactgcactatctgttgcggctgctgaccttcctc cttggacctggcgctggcggagctgaagctcaaggcatgcttggcagagccctgctgctgtcatccctgcc tgacaactgcagcttctgggacgccttcagacctgaaggacgcagaagcgtgctgaggaccatcggcgagt acctggaacaggatgaggaacagcctacaccaagcggcttcgaacccaccgtgaatcctagcagcggcatc tccaagatggaactgctggcctgcttcagccccgtgctgtgggatctgctgcagagggaaaaaagcgtgtg ggccctgcagatcctggtccaggcctatctgcacatgcctccagagaacctgcaacagctggtgctgtctg ccgagagagaagctgcccagggattcctgactctgatgctgcagggaaagctgcagggcaaactccaggtg ccacctagcgaagaacaggcccttggcagactgacagcactcctgctccagagataccccagactgacctc tcagctgtttatcgatctgagccctctgatcccattcctggccgtgtccgacctgatgagattccctccta gtctgctggccaacgactccgtgcagcagggatacagaggcagcgaggaaaacagcctggaagaggacaaa ggcctgcggcctatgacacctagatctctggccgccatccgggattacagccctggaatgaggcccgagca gaaagaggccctggctaagagactgctggctcccgagctgtttggcgaagttccagcctggcctcaagaac tgctgtgggctgttctgcccctgctgccacatctgcctctggaaaacttcctgcagctgagcccacaccag attcaggccctcgaggattcttggcctgccgctggactcggacctggacatgctagacacgtgctgagaag cctggtcaaccagagcgttcaggacggcgaggaacaagtgcggagacttggacccctggcctgttttctga gccccgaggaactgcagagtctggtgcctctgtctgaccctacaggccctgttgaaaggggcctgctggaa tgtgccgccaatggaacactgagccctgagggcagagtggcctatgaacttctgggagtgctgagatctag cggcggagccgttctgtcccctagggaacttagagtgtgggcacccctgtttagccagctgggcctgagat tcctgcaagagctgtctgagccacagctgagggctatgctgcctgtgctccagggcacatctgtgacacca gctcaagccgtcctgctgttgggcagactgctccctagacacgatctgtccctggaagaactgtgcagcct gcacttgctgctgcctggactgtctcctcagacactgcaggccattcctcggagagtgcttgtgggagcct gtagctgtctggcccctgagctgtctagactgagcgcctgtcaaacagccgctctcctgcagaccttcaga gtgaaggatggcgtgaagaacatgggcaccacaggcgctggacctgccgtgtgtattcctggacagcagcc cattcctaccacctggccagattgtctgctcccactgctgcccctgaaactgctgcagctggattctctgg ctctgctggctaaccggcggagatattgggaactgccttggagcgaacagcaggcacagttcctgtggaag aagatgcaggtccccaccaatctgacactgcggaatctgcaggctctcggcacacttgctggcggaatgag ctgcgagttcctccagcagatcaacagcatggtggactttctggaagtggtgcacatgatctaccagctgc caaccagagtgcggggaagcctgagagcttgtatttgggctgaactgcagcggcggatggccatgcctgaa cctgaatggacaacagtgggccccgagctgaacggcctggactctaaacttctgctggatctccccatcca gctgatggacagactgagcaacgagagcatcatgctggtggtggaactggtgcagagagccccagaacagc tgctggcactgacacctctgcatcaagctgctctggccgaacgggcccttcagaatctggctcccaaagaa acccctgtgtccggggaagtgctggaaacactgggacctcttgtgggcttcctgggcaccgagtctaccag acagattcctctccagatcctgctgtcccacctgagccagctccagggattttgtctgggcgagacattcg ccaccgaactcggatggttgctgctccaagagagcgtgctgggaaagcccgaactgtggtcacaggacgaa gtggaacaggccggcagactggtgtttaccctgtctaccgaggccatcagtctgatccccagagaagcact gggccctgaaacactcgagaggctgctggaaaagcagcagtcttgggaacagagcagagtgggccagctgt gtagagaacctcagctggccgctaaaaaggccgcactggttgctggcgttgtcagacctgctgccgaggat ctgccagagccagtgcctaattgtgccgatgtgcggggcacatttcctgccgcttggagcgctacacagat cgccgaaatggaactgagcgacttcgaggactgtctgactctgtttgccggcgatcctggactgggaccag aagaactgagagccgccatgggcaaagccaagcaactttggggacctccaagaggcttcagacccgaacag attctgcagctcggccgcctgcttatcggactgggcgatagagagctgcaagaactgatcctggtggactg gggcgtgctgtctactctgggacaaatcgacggctggtccaccacacagctgcggattgtggtgtccagct tcctgaggcagtctggcagacatgtgtctcacctggacttcgtgcacctgactgccctgggctacacactg tgtggactgcggcctgaggaacttcagcacatcagctcttgggagttcagccaggcagccctgtttctggg aaccctgcatctgcagtgctccgaagaacaactggaagtgctcgcccatctgctcgtgctgccaggcggat ttggccccatctctaattggggacccgagatcttcaccgagatcggcaccattgccgctggcatccctgat ctggccctgtctgcactgctgagaggacagatccagggcgtgacaccactggccattagcgtgatccctcc accaaagttcgccgtggtgtttagccccattcagctgtccagcctgacatctgcccaagccgtggctgtga cccctgaacagatggcatttctgtctcccgagcagcggagagctgttgcttgggctcaacacgagggcaaa gagagtcctgagcaacagggaagaagcaccgcttggggactgcaggattggtccagaccttcttggtcact ggtgctgaccatcagctttctgggccacctcctgtga

[0154] A non-limiting example of a human wildtype stereocilin genomic DNA sequence is SEQ ID NO: 37. The exons in SEQ ID NO: 37 are: nucleotide positions 1-142 (exon 1), nucleotide positions 445-1230 (exon 2), nucleotide positions 1319-1343 (exon 3), nucleotide positions 2111-3368 (exon 4), nucleotide positions 4325-4387 (exon 5), nucleotide positions 4489-4605 (exon 6), nucleotide positions 4748-4914 (exon 7), nucleotide positions 5570-5756 (exon 8), nucleotide positions 5895-6010 (exon 9), nucleotide positions 6292-6424 (exon 10), nucleotide positions 6777-6959 (exon 11), nucleotide positions 7264-7302 (exon 12), nucleotide positions 7486-7653 (exon 13), nucleotide positions 7817-7882 (exon 14), nucleotide positions 8364-8489 (exon 15), nucleotide positions 9467-9525 (exon 16), nucleotide positions 10598-10721 (exon 17), nucleotide positions 10826-10938 (exon 18), nucleotide positions 13402-13537 (exon 19), nucleotide positions 13955-14151 (exon 20), nucleotide positions 14350-14440 (exon 21), nucleotide positions 14649-14805 (exon 22), nucleotide positions 15390-15559 (exon 23), nucleotide positions 17250-17405 (exon 24), nucleotide positions 17787-17929 (exon 25), nucleotide positions 18119-18267 (exon 26), nucleotide positions 18509-18605 (exon 27), nucleotide positions 18694-18841 (exon 28), and nucleotide positions 19041-19238 (exon 29). The introns are located between each of these exons in SEQ ID NO: 37, i.e., at nucleotide positions 143-444 (intron 1), nucleotide positions 1231 to 1318 (intron 2), nucleotide positions 1344-2110 (intron 3), nucleotide positions 3369-4324 (intron 4), nucleotide positions 4388-4488 (intron 5), nucleotide positions 4606-4747 (intron 6), nucleotide positions 4915-5569 (intron 7), nucleotide positions 5757-5894 (intron 8), nucleotide positions 6011-6291 (intron 9), nucleotide positions 6425-6776 (intron 10), nucleotide position 6960-7263 (intron 11), nucleotide positions 7303-7485 (intron 12), nucleotide positions 7654-7816 (intron 13), nucleotide positions 7883-8363 (intron 14), nucleotide positions 8490-9466 (intron 15), nucleotide positions 9526-10597 (intron 16), nucleotide positions 10722-10825 (intron 17), nucleotide positions 10939-13401 (intron 18), nucleotide positions 13538-13954 (intron 19), nucleotide positions 14152-14349 (intron 20), nucleotide positions 14441-14648 (intron 21), nucleotide positions 14806-15389 (intron 22), nucleotide positions 15560-17249 (intron 23), nucleotide positions 17406-17786 (intron 24), nucleotide positions 17930-18118 (intron 25), nucleotide positions 18268-18508 (intron 26), nucleotide positions 18606-18693 (intron 27), and nucleotide positions 18842-19040 (intron 28).

TABLE-US-00012 Human Wildtype Stereocilin Gene (NCBI Accession No. NG_011636.1)  (SEQ ID NO: 37) 1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac  61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg  121 ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga  181 gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag  241 gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac  301 ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca  361 ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt  421 gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc  481 ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc  541 tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga  601 gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc  661 atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag  721 gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg  781 caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc  841 ctaccccaac tcggccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg  901 actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg  961 tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc  1021 actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggc tccaaggagg  1081 ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcc tttcaggagg  1141 ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttg gggcagccag  1201 agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgg gactgggatg  1261 tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttc cctcctaggt  1321 aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagg gattgggcct  1381 ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaa ctgatgggag  1441 gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccag ctccacctct  1501 tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagt ttccccattt  1561 ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggtt aaatgagttg  1621 atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaat aatgttagct  1681 agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccc cttactactt  1741 cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcaga tttcctaaca  1801 tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tacgaagaaa ggagacagaa  1861 gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgat tttggacctt  1921 ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaa cgcctaaact  1981 ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagg gctctgagtc  2041 agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcct gctcctccct  2101 ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctg ggctttctgt  2161 ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggc gtgcctctgc  2221 ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagcc atcactgtgg  2281 aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttcc aacttctcca  2341 tccacttgct ctgccagcac accaagcctg ccactccaca gccccatccc agcaccactg  2401 ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcc caaggctggc  2461 tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgc agtaacctct  2521 ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgt gctggcctgc  2581 tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcacc ccagacatct  2641 tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgt ggggaggcaa  2701 gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgc cagggcccca  2761 ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaa cgctgcccgg  2821 atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgag gtcctggtgc  2881 ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaat gacacttgct  2941 tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactggga ccatccccac  3001 tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgcca cgctgtcagt  3061 cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgc ctgctgacct  3121 tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgcbgggt cgggccctac  3181 tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgccca gagggccggc  3241 gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcag ccaaccccat  3301 caggctttga acccactgtc aaccccagct ctggtataag caagatggag ctgctggcct  3361 gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaa ggccctccag  3421 gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagc acacagctct  3481 agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaa tgagttattt  3541 aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgat aatggtatat  3601 gagataatac atgcbgtggg cttagcacag tgcatgatac acaaacatgc aataaatatt  3661 accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaa agaaaaagga  3721 tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggc tggcagaata  3781 caggaagata aggtaggaat gagaaagatt cagggacact accaatcaga agactttggt  3841 tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttc atttagtttt  3901 tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaa acaccataat  3961 taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtag gatatataaa  4021 gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagta aaatggaatt  4081 agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaa ctatggacct  4141 ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaa agagcttaat  4201 atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggag ctggaatgcc  4261 tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtc tttcttccca  4321 ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccc tgcagattct  4381 agtgcaggta acaggtggag ggcacatggg tgggcbgggt gacagccatg gctggaggtc  4441 cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggc gtacctgcat  4501 atgcccccag aaaacctcca gcagcbggtg ctttcagcag agagggaggc tgcacagggc  4561 ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgag cactgagaaa  4621 ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgg gaggaggaac  4681 tccagagagg aaatggcagg gatactgagc atctccagag gcagaatcca ttcctgtgcc  4741 cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccc tgctgctcca  4801 gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactca tccctttctt  4861 ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgaca gtgtgtaagg  4921 ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatcca cctggagcag  4981 ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaat gtgccaacat  5041 cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaaccca atcattatgc  5101 taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggag aggatgggcg  5161 tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtgg atcactaggt  5221 ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccccgtct ctattaaact  5281 acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactct ggaggctgag  5341 gcaggaggat agcttgaacc tgggaggcag aggttgcagt gaaccaagat cgtgccactg  5401 cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaa acaaaacaaa  5461 acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacaga gggtcagagg  5521 aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagc ctggctgcca  5581 tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggca aagcgactgc  5641 tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctg tgggcagtgc  5701 tgcccctgct cccccacctc cctctggaga actttttgca gctcagccct caccaggtat  5761 gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaa agagtcaatg  5821 gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagt gcgagctaac  5881 cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggt ctggggccag  5941 ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggat ggtgaggagc  6001 aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaa gaggtagaga  6061 gaggaaggca cagcbgtcac gcbgggtcgg tgttctagga agaaaggggc aagagagtag  6121 gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggt gcccctgtgt  6181 agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgc caggcctgcc  6241 ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctca ggcttgggcc  6301 cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac  6361 ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg  6421 acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctggg tctgtgtgga  6481 tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatccc acttttgcaa  6541 cctccattcc ttactccatg gccattctta cctgttacca cctcttcctg gcccttctct  6601 atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatc tactccagtc  6661 caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgg gattagagag  6721 gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttgg ttacaggtgg  6781 catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagc ccccgggagc  6841 tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcag gagctgtcag  6901 agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttaca cctgctcagg  6961 tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagcccc agtcaagaga  7021 atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtag aggtaaactc  7081 tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacc tgagtcactg  7141 aggatggtta ctagggatgg ttaagaggca gcgggaagtt ttggagggtt tgccttagga  7201 acccacttag gacctggctg ctgggtcctg agagcbgttg ttttcggtcc catcccaaca  7261 caggcbgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtag cagcaacttc  7321 tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatc tgcccctcct  7381 ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgt cttccccaac  7441 acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatc cctggaggaa  7501 ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactcca ggccatccct  7561 aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacg cctctcagcc  7621 tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaagg aggatgagat  7681 aatcagggat accggctctt tctggttggg aggaaggcat cttccctgag gccagggaag  7741 gcctttcata cctccccact tacacacaca cacacacaca cacacacaca cacacacaca  7801 accaattctc atgcaggtta aagatggtgt taaaaatatg ggtacaacag gtgctggtcc  7861 agcbgtgtgt atccctggtc aggtaagtgt gagatctccc aactgagctc ctctccccat  7921 tctggggcag tttcatatgg ctggtgctac ctcccacact accctgcagt ggccctgaga  7981 gttctggtta gctctgtgcc cattagcagc cctccccagt gccagatgca ggacagcatg  8041 atccactcac attgtcctag actaatgtca aagctggaag ggcctgagaa atcttccagg  8101 ccacccaccc tgctttcaga tgaaaagacc aaggcbggga gaagctaagg gactttgttt  8161 gcctggtgcc taactagcag caacacttga ccacagcagc ctgcagtgtg aggctcttag  8221 gcgtttattg ctacagtggc aaatgccatt ccacttctgt cctagctttg gtccctttcc  8281 acccccatgg ttccttttct ctgagtgcta agtacagact ctctcaccta tcactacact  8341 gctataccca tcaccgccag cagcctattc ccaccacctg gccagactgc ctgcttcccc  8401 tgctcccatt aaagctgcta caactggatt ccttggctct tctggcaaat cgaagacgct  8461 actgggagct gccctggtct gagcagcagg taattctccc cacttaattt cagaacttcc  8521 tccctcaatg tagtctacct tctttaccta tcccttagcc ctatttggcc agcttatccc  8581 tactatcctt tatttgattg tttgagatac agtctcactc tgttgcccag gctgcagtgc  8641 agtggcatga tcagagttcg ctgtaacctc aaactcctga gctcaggcaa tctttctgcc  8701 tcagcctcct gaatagctag gacgacaggt ggttaccacc atgcctggct aatttttaaa  8761 tttttttttt gttttttgag atgaagtctt gctctgtcac ccaggcttga gtacagtggc  8821 acaagcttgg ctcactgcaa cctctgtctc ccgggttcaa gcgattctcc tgcctcagcc  8881 tcccgagtag ctgggactac aggcactccc cacaatgcct ggctaatttt ttttttgttt  8941 tagtagagac agggtttcac catattggcc aggctggtct cgaactgctg accttgtgat  9001 ctgcctgcct ctgcctctca aagtgctggg attacaggtg tgagccacca tgcccggcca  9061 atttttaaat tttttgtaga gacagacaat acaaaaatgt ggacactatg tggagacact  9121 atgttgaggt actatgctgt ccagattggt cttgaactcc tggcctcaag caatcctcct  9181 gccttggcct cccaaagtgc tgggattaca gacctgagcc actgcaccca gccccctagt  9241 atctcttata atgtgacttg cttttctttt tctttctcct tcccttttct ttcatttctt  9301 tctcactctc gagagaagag tgggcatctg ggagagtggg aggctggtgg gtcccacaga  9361 gtgaggaggc aggactgggt ccaaggcagt cctgcctctc cactctaggg ggtatccttg  9421 gacagtgtct cttctgggaa ggggctcgtc tttctttctc ttgtaggcac agtttctctg  9481 gaagaagatg caagtaccca ccaaccttac cctcaggaat ctgcagtgag taacttgtgt  9541 tgagcagtgc gctgaattcg accaacattt ttttgagtgc ttactatgtg ccaggcacca  9601 tgtgatatgg aatgggggat atagggatga atgatgcata gtccctgcct cgtggacgtt  9661 ctcctagcac ctccctttgc cctcctttcc ttccacagtg ccatgcctat cctgactaga  9721 gccaaaggac tcagaaaacc tggattcagg ttccagtcct gtcacctact tgtcctcttg  9781 ggcaagtcat ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaa ttacaatggc  9841 accagcctca taggtagtta ctgtgaagat taaatgaggt aggtcatgta agatatttaa  9901 cacagtgttt ggtccattgt aaagtcccag tagtcatttg ctactgttag tttacttcag  9961 gatgacttca gaggcactgg ccaagcaaga ataaatagga ataagaaggt atcactttac  10021 ttacacccac attagaagaa caatgggctt cagaatcttt tttttttttt ttttttcgag  10081 acagtcttgc tctgttgccc aggctggagt gcagtggcgc gatttcggct cactgcaacc  10141 tctgcctccc aggttcaagc gattctcctg tctcagcctc tggagtagct gggattacag  10201 gaatgtgcca ccatacccag ctaatttttg tatttttagt agagatgggg tttcaccatt  10261 ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acccgcctca gcctcccaag  10321 ggcttcagaa tctaagacat ggctctagtt tcagtttacc acatttctag cagaatgatg  10381 ttgggaatgt cacctgactt ccataaatcc ttattttctc ctctgataaa cagcagtgat  10441 gttatgggga gctgatgaga tatctatgta aaaacatttc tcaaaccata aattacggtg  10501 gatgaacatc tgtacttgtg ttgagagtac tgatatcaag gagcaaacag gctgttgtat  10561 gtgttgaatg agcctctccc cactcacaca cccacagggc tctgggcacc ctggcaggag  10621 gcatgtcctg tgagtttctg cagcagatca actccatggt agacttcctt gaagtggtgc  10681 acatgatcta tcagctgccc actagagttc gagggagcct ggtgagaggg ggtgcctgga  10741 ctttagtggg agcagggagg ctgggaccct aggtatagaa cccagctcct atgttctgct  10801 ctggcctcac actgcttccc tacagagggc ctgtatctgg gcagagctac agcggaggat  10861 ggcaatgcca gaaccagaat ggacaactgt agggccagaa ctgaacgggc tggatagcaa  10921 gctactcctg gacttaccgt aagtactgca gctagagata ttggcccctc agaaagctca  10981 atctggggtg aagatctgcc cttagggaat gccctggagg aggtagtttt tctgtctggt  11041 agttccctga cataatttat agcccaaagc agaggatttt attcaaagtt gctctatgta  11101 ttgactggtt cccagaatat gctccagcac agggcagctg agggtggcaa cactgtattg  11161 aagcctgcca agtaatctta caataaccta gtccacatta attgagattg agacagagca  11221 tctgaagtga gggaggcaat gctccaaatc tgccccagag gattgtagtt tgctcagggc  11281 actgtgttct tagtgcattc agaggagtag atcgagagaa aaatatatga aaaatgtgat  11341 aaataccttc aaatacctga ggggctatca agtagaaatt agattgtcat atttatgagt  11401 ggccccattg ggcaagacta agagtagtta acggagatca gatttttaca tagtataaga  11461 aaaactaagg tagtgagttc ctggtccttg gagcbgttcg agcctaagcc agatggcccc  11521 atggcaggaa tgttgtagag cacgttcata tacaggttgt gggaagaaaa ggctatagga  11581 acccaaggct cctccctacc catggagaaa tttattagta tgttactcat atgctgcttt  11641 tctcatttta cccctaccac caccccgttg ccatccgcac tgtaagtcag gataggaaaa  11701 tgcbggtgtt acagtcttcc tggggaatat ggagctgaag tggagtaaaa gcagttgact  11761 tcattcctac ttttttcttt tttttctttt tttttttttt tgagacagag ttttgctgtg  11821 tcaccaaggc tggagtgcag tgacgtgatc tcggctcact gcaacctcca tcttccaggt  11881 tcaagcaatt ctcctgcctc agtctcccga gtagcbggga ctgtaggtgt gcaccaccat  11941 gccaggctaa tttttgtatt tgttgtaggg acgagctttc accatgttgg ccaggctggt  12001 cttgaactcc tggcttcaag tgatctgccc acctcggctt cccaacattc ttatattttt  12061 ataggccttt ccacagattt cagctcttgt atgacttagc ccagttccag aactggtaat  12121 cctaggtagg gtacaggtta tcacctctga tttcgggtaa aagggattta tttatttatt  12181 tgtttattta tttatatttt tgagacagag tctcgctctg tcacccaggc tggagtgcaa  12241 tggtgccatc tcggctcact gcaacctctc cctctggggt tcaagcaatt ctcctgcctc  12301 agcctgctga gtagcbggga ttacaggcgc gtgccaccac acccggctaa tttttgcatt  12361 tttagtagag acggggtttc accatgttgc tcagggtggt ctcgaatttc tgaccctgtg  12421 atctgcctgc ctcggcctcc caaagtgctg ggattacagg catgagccac tgcgtccggc  12481 ctgtttttac ttttttttaa tgccattcag atctgtttaa atatgtgggt tctgtgagat  12541 aatttagaat cccaaggtta cagatgaggt gaaagatcct agaccatgca tcaaaaaact  12601 tgagtttctc atttgtgaaa gaaggataag agaaacacct attttgtctg ggtgcagtgg  12661 ctcatgccta taatcccagc atttggggag gccaaggtgg gtggatcacg gaggtcaggt  12721 gttcaagacc agactggcca acatggcaaa acaccatctc tactaaaaat acaaaagtta  12781 gcbgggcgtg gtggcacgtg cgtgtaattc cagctattcg ggaggctgag gcacgagaat  12841 tgcttgaacc tgggaggtgc gggttgcagt gaactgagat cgcagcacca ctgtgctcca  12901 gcctgagtga tggagtgagg ccaggtcttg ttgtaggatc aaatgagata acacctgaaa  12961 gaactttgta aattgtatag cacgtacaaa caagaaggga cctcttcaca agcagaggaa  13021 gggtggtcct gtggaaaaaa acgggaattg ggagtgagag acctcaacat ttgatctctg  13081 tgaacctcag ttttttaatc tataaaatgg ggaaatgtta atggtactta atatttggag  13141 cttttgagtc cattagatca ggtaggattg ttcgttattt ttttttttta ggaagactag  13201 aaatatgttg ctcccttttt ctcccccact caagcttgat ggtgggaatt ggccctggag  13261 ctgtttacta tcagttcctg tccagcttca ctaaatttgg tctggggtca catcttagct  13321 gcggactgtg gggttttgtg gtcccttctc gacttggccc agctccacct gaatcctgtt  13381 gttgtcaaat tgctgtaata ggatccagtt gatggacaga ctatccaatg aatccattat  13441 gttggtggtg gagctggtgc aaagagctcc agagcagctg ctggcactga cccccctcca  13501 ccaggcagcc ctggcagaga gggcactaca aaacctggta agagtccacc ctaccagact  13561 cagatttgct gccctgggca attcttgctc ctcagacaat gctctctgac tgtcccccaa  13621 ccctctactt cttgctttct tgctgccaaa cagattcctg tctacaaggc ctggcccctg  13681 ttttgcctct gggttctgtt ccttgataat atgcttcacg ttacttgtcc atacctcttg  13741 gagtccgaga aatctcttgg agtccacctc tcagtctttc tgcctgctcc tatctgggct  13801 cattgcttaa ggaagtgaac aaaggtagtg agcatcatag ggtgctgagc tgggagcagg  13861 agggagggaa ggttaggggg cttggtgtct tgatcaaggt gtctggtatt ctgagtcaga  13921 agtgcattgt ccaagttctg atgctcttct ccaggctcca aaggagactc cagtctcagg  13981 ggaagtgctg gagaccttag gccctttggt tggattcctg gggacagaga gcacacgaca  14041 gatcccccta cagatcctgc tgtcccatct cagtcagctg caaggcttct gcctaggaga  14101 gacatttgcc acagagctgg gatggctgct attgcaggag tctgttcttg ggtatggacc  14161 ttcgagaact tcagattcta actcattcta tacccagtcc ctcagccacc atcatcagtg  14221 gcagcctgtt ccatattctt aaggtcccct ggagccctgt gtccgaaatc ctagcatgtc  14281 ctcttttccc cttccttttc ctcacagttc cctcagctcc ccagcccccg attttcttcc  14341 tgtccccagg aaaccagagt tgtggagcca ggatgaagta gagcaagctg gacgcctagt  14401 attcactctg tctactgagg caatttcctt gatccccagg gtgagatgaa ggaagaaggg  14461 aagggagtaa atgcatagag gggactggtg agctggttat ggggacccgt ggccaaagag  14521 ggcaaaggat atgaagccta gatctggggg gagactgcaa aacagagaca ggactttgga  14581 cttagagcta tagcagcagg tcctgatctg tccagatctc cccactctcc ttctaccttc  14641 tcatgcagga ggccttgggt ccagagaccc tggagcggct tctagaaaag cagcagagct  14701 gggagcagag cagagttgga cagctgtgta gggagccaca gcttgctgcc aagaaagcag  14761 ccctggtagc aggggtggtg cgaccagctg ctgaggatct tccaggtgaa actacccaaa  14821 tacttatatg tccagcagga tgtacaggga gtatcaaacg gtctgggttc tacatgtgct  14881 cttccctggg actgggtttt ctaatttata aagcaaagag tttagaggga tgatcttcaa  14941 gcctcttgta gttctagaat tctgtagttc tgggagtttg taaactatta agttttcttt  15001 tagcccagaa cttccatttt cctgctctct cgtgtctgct ctagactcag ctctagctcg  15061 gctaagtgtg gagctctctg ctggggagat ccctagaagc tttgaaggag acattgtgag  15121 gctggagaac tgggttcaaa ttcagtgcta ccattaaatc tctgaataac atcctcagtc  15181 ttccatctat aaaagtcttg gcatctccaa tcacttcttg ttctattatc tcctaagccc  15241 tatacatatt actctgtaat actcctttga tccctatttc tcacagtgct ctatcctcca  15301 aaggttggaa gactcactct atctacagat atctctctgg gcatatttta ttactgcgct  15361 gacctcctgg ccctgccttc ccccttcaga acctgtgcca aattgtgcag atgtacgagg  15421 gacattccca gcagcctggt ctgcaaccca gattgcagag atggagctct cagactttga  15481 ggactgcctg acattatttg caggagaccc aggacttggg cctgaggaac tgcgggcagc  15541 catgggcaaa gcaaaacagg ttagggatgg agagccaact ggggttggcc atgaggaagc  15601 tatttgggtg tgatgtagga cacaaagaga atggagagtt ggatgagagg tgggggaagc  15661 aagagataga agagttagaa gatttgggtc acaagtagga ggtgaaggga gataaatatt  15721 gaggaaagag agctagtata atgaatagag ggacgaaagc agtggttacc aaattttaat  15781 gcatatcacg atcatcaagg gaacagattt ttttctttat ttttttttct ttcttaaaaa  15841 aataatggca tgcttcggct gggtgcagcg gctcacgcct ataatctcag aactttggga  15901 ggccaaggcg ggcagatcac gaggtcagga gatcaagacc atcctgtcta acacggcgaa  15961 acacggtctc tactaaaaat acaaaaaagt tagccgggca tggtggtgca cacttgttgt  16021 cccagctact tgggaggctg aggcaggaga atggcgtgaa cctgggaggg ggagcttgca  16081 gtgagccgaa gtcaagccaa tgcactccat cctgggtgac agagcaagac tccatctcaa  16141 aaaaaaaaaa aaaaaaaaaa ggcatgcttc atgaatttgc gtgttatcct tgcacaggcg  16201 ccatgcaaat ctctgtatca ttccaatttt ttggggtatg tgctgctgaa ctgagcatgg  16261 gaacagtgcc agtgccagat taccatgctt cactgactta ataaaaacct ttggggaggc  16321 tgggcgcagt gactcatgcc tgtaatcaca gcactttggg aggcggaggc aggtggattg  16381 cttgagccca ggagttagag accagactgg gcaacatggt gaaaccctgt ctctactaaa  16441 aatagaaaaa acattagctg ggtgtggcgg cacatgcctg taatcccagc tactcaggag  16501 gcbggggtag gagaatccca tgagtgcagg aggtggaggg tgcaatgtgc caagatcgca  16561 ccactgccct ccagcctggg tgtcagagca agaccctgtc tcataaatta aaaaataagc  16621 ctctggggga aagagtctag acatctgcat ctcctttttt tttttttttt tttttttttg  16681 agacagagtc tcactctgtc acccagcatc caggctggag tgcagtggtg tgatcttggc  16741 tcactgtaac ctctacatcc tgggttcaaa cgatcctcct gcctcagcct ctcaagtagc  16801 tgggactaca ggtgcaccac acctggctaa tttttgtatc tttggtagag atggggtttc  16861 actatgttgc ccaggatggt ctcgaacttc tgggctcaag caatcctccc acctcagcct  16921 cccaaagtgc tgggattaca gcbgttagcc actgtgctgg gccctaggca tctgttttaa  16981 taagcgtctc tgtgtctgat gcacataaaa gtgtggaact catggactag agttagtttg  17041 ctcttctttt ccactgattg taatgtcttt caaaacacct tagaggaact gtaaggcaac  17101 ggtctcattt tatagtggag gaaactaaag aaaaggcaaa tgatttacct agagttatac  17161 agctaagggc agaggcaaga cttaaaaccc agcagtatga ctcccaatcc actgcttttc  17221 cactcacatt gttcctgtct ttctcctagt tgtggggtcc cccccgggga tttcgtcctg  17281 agcagatcct gcagcttggt aggctcttaa taggtctagg agatcgggaa ctacaggagc  17341 tgatcctagt ggactgggga gtgctgagca ccctggggca gatagatggc tggagcacca  17401 ctcaggtaac acttttcctc ctccctacgg cttcccaaac acccatccca cagacccagc  17461 cctatagatc atctaaagcc caaggaattt ttttcctgtg accctacctg gtccttcttt  17521 ctatcttttg ttgatacccc atactagtga ccttcaggac tctgatttat tcactctgag  17581 gccctggaca cataatactg tctcctacct cttttcctgg aggcttcctc tttttctttc  17641 cttttctttt ctgagtcctc agccttcccc atgactcctt aggtcttaat agtaacagaa  17701 tataacccag taacacctat cacttccctg tccattaatt ctccataact ttcctccttc  17761 ccctcttctc ccacccccca ccccagctcc gcattgtggt ctccagtttc ctacggcaga  17821 gtggtcggca tgtgagccac ctggacttcg ttcatctgac agcgctgggt tatactctct  17881 gtggactgcg gccagaggag ctccagcaca tcagcagttg ggagttcagg tcatttgtga  17941 aggggctgag ggtggtggtg ctgaggtaaa ggtggactta ctggggaaag aaggatcatg  18001 aaggtctggt cccatggagg aagggaactc atttgaagcc atctcttcct ttgtctcatg  18061 accacagccc ctttcactga agccgaattc ttcttccttc cttcctactg ttctacagcc  18121 aagcagctct cttcctcggc accctgcatc tccagtgctc tgaggaacaa ctggaggttc  18181 tggcccacct acttgtactg cctggtgggt ttggcccaat cagtaactgg gggcctgaga  18241 tcttcactga aattggcacc atagcaggtg gggagctggg ccactgctgg tgcaagttgg  18301 tttggtttct ataccatggg tggactggat ggaagactgc cctgcaattc ttaaggtggg  18361 ggcctgaggg tgtttaaata aggggctaga gacatattgg ggaaggtcta tgatagggca  18421 ctttgggagt agttagagaa ggtctatagg tttgaagaga gggaaggtca gtctaagaca  18481 atgtttggat gccacttgct tcaacagctg ggatcccaga cctggctctt tcagcactgc  18541 tgcggggaca gatccagggc gttactcctc ttgccatttc tgtcatccct cctcctaaat  18601 ttgctgtaag tattaatgga ctggggtgac cacaggagag ccagggccca atggggacta  18661 catgcatgca ctgattccta cccctgccct caggtggtgt ttagtcccat ccaactatct  18721 agtctcacca gtgctcaggc tgtggctgtc actcctgagc aaatggcctt tctgagtcct  18781 gagcagcgac gagcagttgc atgggcccaa catgagggaa aggagagccc agaacagcaa  18841 ggtgagttcc cagctgcaca gcttgatcct ccatctcctg acccagaatc aaacccctaa  18901 tttggtgctg tctggctctt agagtgcacc cagggagatc cctggagtga aggagtctac  18961 aggcagagcg ctaatttcca agtatcaatg ctcctggaga gctgagttgt gatattactc  19021 ccattccctg tctattatag gtcgaagtac agcctggggc ctccaggact ggtcacgacc  19081 ttcctggtcc ctggtattga ctatcagctt ccttggccac ctgctatgag cctgtctcta  19141 cagtagaagg agattgbggg gagagaaatc ttaagtcata atgaataaag tgcaaacaga  19201 agtgcatcct gattattttc agaagctgat gaggaata 

[0155] The nucleotide sequence of the human STRC pseudogene is shown in SEQ ID NO: 38.

TABLE-US-00013 Human Stereocilin Pseudogene 1 (STRCP1) (SEQ ID NO: 38)  1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac  61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg  121 ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga  181 gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag  241 gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac  301 ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca  361 ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt  421 gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc  481 ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc  541 tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga  601 gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc  661 atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag  721 gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg  781 caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc  841 ctaccccaac tcagccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg  901 actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg  961 tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc  1021 actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggc tccaaggagg  1081 ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcc tttcaggagg  1141 ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttg gggcagccag  1201 agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgg gactgggatg  1261 tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttc cctcctaggt  1321 aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagg gattgggcct  1381 ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaa ctgatgggag  1441 gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccag ctccacctct  1501 tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagt ttccccattt  1561 ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggtt aaatgagttg  1621 atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaat aatgttagct  1681 agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccc cttactactt  1741 cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcaga tttcctaaca  1801 tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tatgaagaaa ggagacagaa  1861 gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgat tttggacctt  1921 ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaa cgcctaaact  1981 ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagg gctctgagtc  2041 agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcct gctcctccct  2101 ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctg ggctttctgt  2161 ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggc gtgcctctgc  2221 ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagcc atcactgtgg  2281 aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttcc aacttctcca  2341 tccacttgct ctgccagcac accaagcctg ccactccaca gccccatccc agcaccactg  2401 ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcc caaggctggc  2461 tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgc agtaacctct  2521 ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgt gctggcctgc  2581 tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcacc ccagacatct  2641 tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgt ggggaggcaa  2701 gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgc cagggcccca  2761 ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaa cgctgcccgg  2821 atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgag gtcctggtgc  2881 ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaat gacacttgct  2941 tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactggga ccatccccac  3001 tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgcca cgctgtcagt  3061 cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgc ctgctgacct  3121 tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgcbgggt cgggccctac  3181 tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgccca gagggccggc  3241 gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcag ccaaccccat  3301 caggctttga acccactgtc aaccccagct ctggtataag caagatggag ctgctggcct  3361 gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaa ggccctccag  3421 gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagc acacagctct  3481 agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaa tgagttattt  3541 aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgat aatggtatat  3601 gagataatac atgcbgtggg cttagcacag tgcatgatac acaaacatgc aataaatatt  3661 accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaa agaaaaagga  3721 tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggc tggcagaata  3781 caggaagata aggtaggaat gagaaagatt cagggacact accaatcaga agactttggt  3841 tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttc atttagtttt  3901 tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaa acaccataat  3961 taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtag gatatataaa  4021 gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagta aaatggaatt  4081 agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaa ctatggacct  4141 ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaa agagcttaat  4201 atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggag ttggaatgcc  4261 tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtc tttcttccca  4321 ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccc tgcagattct  4381 agtgcaggta acaggtggag ggcacatggg tgggcbgggt gacagccatg gctggaggtc  4441 cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggc gtacctgcat  4501 atgcccccag aaaacctcca gcagcbggtg ctttcagcag agagggaggc tgcacagggc  4561 ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgag cactgagaaa  4621 ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgg gaggaggaac  4681 tccagagagg aaatggcagg gatactgagc atctccagag gcagaatcca ttcctgtgcc  4741 cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccc tgctgctcca  4801 gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactca tccctttctt  4861 ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgaca gtgtgtaagg  4921 ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatcca cctggagcag  4981 ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaat gtgccaacat  5041 cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaaccca atcattatgc  5101 taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggag aggatgggcg  5161 tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtgg atcactaggt  5221 ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccctgtct ctattaaact  5281 acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactct ggaggctgag  5341 gcaggaggat agcttgaacc tgggaggcag aggttgcagt gagccaagat cgtgccactg  5401 cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaa acaaaacaaa  5461 acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacaga gggtcagagg  5521 aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagc ctggctgcca  5581 tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggca aagcgactgc  5641 tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctg tgggcagtgc  5701 tgcccctgct cccccacctc cctctggaga actttttgca gctcagccct caccaggtat  5761 gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaa agagtcaatg  5821 gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagt gcgagctaac  5881 cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggt ctggggccag  5941 ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggat ggtgaggagc  6001 aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaa gaggtagaga  6061 gaggaaggca cagcbgtcac gcbgggtcgg tgttctagga agaaaggggc aagagagtag  6121 gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggt gcccctgtgt  6181 agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgc caggcctgcc  6241 ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctca ggcttgggcc  6301 cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac  6361 ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg  6421 acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctggg tctgtgtgga  6481 tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatccc acttttgcaa  6541 cctccattcc ttactccatg gccattctta cctgttacca cctcttcctg gcccttctct  6601 atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatc tactccagtc  6661 caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgg gattagagag  6721 gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttgg ttacaggtgg  6781 catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagc ccccgggagc  6841 tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcag gagctgtcag  6901 agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttaca cctgctcagg  6961 tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagcccc agtcaagaga  7021 atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtag aggtaaactc  7081 tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacc tgagtcactg  7141 aggatggtta ctggggatgg ttaagaggca gcgggaagtt ttggagggtt tgccttagga  7201 acccacttag gacctggctg ctgggtcctg agagcbgttg ttttcggtcc catcccaaca  7261 caggcbgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtag cagcaacttc  7321 tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatc tgcccctcct  7381 ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgt cttccccaac  7441 acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatc cctggaggaa  7501 ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactcca ggccatccct  7561 aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacg cctctcagcc  7621 tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaagg aggatgagat  7681 aatcagggat accggctctt tctggttggg aggaaggcat cttccctgag gccagggaag  7741 gcctttcata cctccccact tacacacaca cacacacaca cacacacaca accaattctc  7801 atgcaggtta aagatggtgt taaaaatatg ggtacaacag gtgcbggtcc agctgtgtgc  7861 atccctggtc aggtaagtgt gagatctccc aactgagctc ctctccccat tctggggcag  7921 tttcatatgg ctggtgctac ctcccacact accctgcagt ggccctgaga gttctggtta  7981 gctctgtgcc cattagcagc cctccccagt gccagatgca ggacagcatg atccactcac  8041 attgtcctag actaatgtca aagctggaag ggcctgagaa atcttccagg ccacccaccc  8101 tgctttcaga tgaaaagacc aaggcbggga gaagctaagg gactttgttt gcctggtgcc  8161 taactagcag caacacttga ccacagcagc ctgcagtgtg aggctcttag gcgtttattg  8221 ctacagtggc aaatgccatt ccacttctgt cctagctttg gtccctttcc acccccatgg  8281 ttccttttct ctgagtgcta agtacagact ctctcaccta tcactacact gctataccca  8341 tcaccgccag cagcctattc ccaccacctg gccagactgc ctgcttcccc tgctcccatt  8401 aaagctgcta caactggatt ccttggctct tctggcaaat cgaagacgct actgggagct  8461 gccctggtct gagcagcagg taattctccc cacttaattt cagaacttcc tccctcaatg  8521 tagtctacct tctttaccta tcccttagcc ctatttggcc agcttatccc tactatcctt  8581 tatttgattg tttgagatac agtctcactc tgttgcccag gctgcagtgc agtggcatga  8641 tcagagttcg ctgtaacctc aaactcatga gctcaggcaa tctttctgcc tcagcctcct  8701 gaatagctag gatgacaggt ggttaccacc atgcctggct aatttttaaa tttttttttt  8761 gttttttgag atgaagtctt gctctgtcac ccaggcttga gtacagtggc acaagcttgg  8821 ctcactgcaa cctctgtctc ccgggttcaa gcgattctcc tgcctcagcc tcccgagtag  8881 ctgggactac aggcactccc cacaatgccc ggctaatttt ttttttgttt tagtagagac  8941 agggtttcac catattggcc aggctggtct cgaactgctg accttgtgat ctgcctgcct  9001 ctgcctctca aagtgctggg attacaggtg tgagccacca tgcccggcca atttttaaat  9061 tttttgtaga gacagacaat acaaaaatgt ggacactatg tggagacact atgttgaggt  9121 actatgctgt ccagattggt cttgaactcc tggcctcaag caatcctcct gccttggcct  9181 cccaaagtgc tgggattaca gacctgagcc actgcaccca gccccctagt atcccttata  9241 atgtgacttg cttttctttt tctttctcct tcccttttct ttcatttctt tctcactctc  9301 gagagaagag tgggcatctg ggagagtggg aggctggtgg gtcccacaga gtgaggaggc  9361 aggactgggt ccaaggcagt cctgcctctc cactctaggg ggtatccttg gacagtgtct  9421 cttctgggaa ggggctcgtc tttctttctc ttgtaggcac agtttctctg gaagaagatg  9481 caagtaccca ccaacctgac cctcaggaat ctacagtgag taacttgtgt tgagcagtgc  9541 gctgaattcg accaacattt ttttgagtgc ttactatgtg ccaggcacca tatgatatgg  9601 aatgggggat atagggatga atgatgcata gtccctgcct cgtggacgtt ctcctagcac  9661 ctccctttgc cctcctttcc ttccacagtg ccatgcctat cctgactaga gccaaaggac  9721 tcagaaaacc tggattcagg ttccagtcct gtcacctact tgtcctcttg ggcaagtcat  9781 ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaa ttacaatggc accagcctca  9841 taggtagtta ctgtgaagat taaatgaggt aggtcatgta agatatttaa cacagtgttt  9901 ggtccattgt aaagttccag tagtcatttg ctactgttag tttacttcag gatgacttca  9961 gaggcactgg ccaagcaaga ataaatagga ataagaaggt atcactttac ttatacccac  10021 attagaagaa caatgggctt cagaatcttt tttttttttt ttttcgagac agtcttgctc  10081 tgttgcccag gctggagtgc agtggcgcga tttcggctca ctgcaacctc tgcctcccag  10141 gttcaagcga ttctcctgtc tcagcctctg gagtagctgg gattacagga atgtgccacc  10201 atacccagct aatttttgta tttttagtag agatggggtt tcaccatttt ggccaggctg  10261 gtctcaaact cctgacctca ggtgatccac ccgcctcagc ctcccaaggg cttcagaatc  10321 taagacatgt ctctagtttc agtttaccac atttctagca gaatgatgtt gggaatgtca  10381 cctgacttcc ataaatcctt attttctcct ctgataaaca gcagtgatgt tatggggagc  10441 tgatgagata tctatgtaaa aacatttctc aaaccataaa ttacggtgga tgaacatctg  10501 tacttgtgtt gagagtactg atatcaagga gcaaacaggc tgttgtatgt gttgaatgag  10561 cctctcccca ctcacacacc cacagggctc tgggcaccct ggcaggaggc atgtcctgtg  10621 agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcac atgatctatc  10681 agctgcccac tagagttcga gggagcctgg tgagagggga tgcctggact ttagtgggag  10741 cagggaggct gggaccctag gtatagaacc cagctcctat gttctgctct ggcctcactc  10801 tgcttcccta cagagggcct gtatctgggc agagctacag cggaggatgg caatgccaga  10861 accagaatgg acaactgtag ggccagaact gaacgggctg gatagcaagc tactcctgga  10921 cttaccgtaa gtactgcagc tagagatatt ggcccctcag aaagctcaat ctggggtgaa  10981 gatctgccct tagggaatgc cctggaggag gtagtttttc tgtctggtag ttccctgaca  11041 taatttatag cccaaagcag aggattttat tcaaagttgc tctatgtatt gactggttcc  11101 cagaatatgc tccagcacag ggcagctgag ggtggcaaca ctgtattgaa gcctgccaag  11161 taatcttaca ataacctagt ccacattaat tgagattgag acagagcatc tgaagtgagg  11221 gaggcaatgc tccaaatctg ccccagagga ttgtagtttg ctcagggcac tgtgttctta  11281 gtgcattcag aggagtggat cgagagaaaa atatatgaaa aatgtgataa ataccttcaa  11341 atacctgagg ggctatcaag tagaaattag attgtcatat ttatgagtgg ccccattggg  11401 caagactaag agtagttaac ggagatcaga tttttacata gtataagaaa aactaaggta  11461 gtgagttcct ggtccttgga gcbgttcgag cctaagccag atggccccat ggcaggaatg  11521 ttgtagagca cgttcatata caggttgtgg gaagaaaagg ctataggaac ccaaggctcc  11581 tccctaccca tggagaaatt tattagtatg ttactcatat gctgcttttc tcattttacc  11641 cctaccacca ccccgttgcc atccgcactg taagtcagga taggaaaatg ctggtgttac  11701 agtcttcctg gggaatatgg agctgaagtg gagtaaaagc agttgacttc attcttactt  11761 ttttcttttt cttttttttt ttttttttga gacagagttt tgcbgtgtca ccaaggctgg  11821 agtgcagtga cgtgatctcg gctcactgca acctccatct tccaggttca agcaattctc  11881 ctgcctcagt ctcccgagta gcbgggactg taggtgtgca ccaccatgcc aggctaattt  11941 ttgtatttgt tgtagggacg agctttcacc atgttggcca ggcbggtctt gaactcctgg  12001 cttcaagtga tctgcccacc tcggcttccc aacattctta tatttttata ggcctttcca  12061 cagatttcag ctcttgtatg acttagccca gttccagaac tggtaatcct aggtagggta  12121 caggttatca cctctgattt cgggtaaaag ggatttattt atttatttgt ttatttattt  12181 atatttttga gacagagtct cgctctgtca cccaggctgg agtgcaatgg tgccatctcg  12241 gctcactgca acctctccct ctggggttca agcacttctg cctcagcctc ctgagtagct  12301 gggattacag gcgcgtgcca ccacacccgg ctaatttttg catttttagt agagacgggg  12361 tttcaccatg ttgctcaggg tggtctcgaa tttctgaccc tgtgatctgc ctgcctcggc  12421 ctcccaaagt gcbgggatta caggcatgag ccactgcgtc cggcctgttt ttactttttt  12481 ttaatgccat tcagatctgt ttaaatatgt gggttctgtg agataattta gaatcccaag  12541 gttacagatg aggtgaaaga tcctagacca tgcatcaaaa aacttgagtt tctcatttgt  12601 gaaagaagga taagagaaac acctattttg tctgggtgca gtggctcatg cctataatcc  12661 cagcatttgg ggaggccaag gtgggtggat cacggaggtc aggtgttcaa gaccagactg  12721 gccaacatgg caaaacacca tctctactaa aaatacaaaa gttagcbggg cgtggtggca  12781 cgtgcgtgta attccagcta ttcgggaggc tgaggcacga gaattgcttg aacctgggag  12841 gtgcgggttg cagtgaactg agatcgcagc accactgtgc tccagcctga gtgatggagt  12901 gaggccaggt cttgttgtag gatcaaatga gataacacct gaaagaactt tgtaaattgt  12961 atagcacgta caaacaagaa gggacctctt cacaagcaga ggaagggtgg tcctgtggaa  13021 aaaaacggga attgggagtg agagacctca acatttgatc tctgtgaacc tcagtttttt  13081 aatctataaa atggggaaat gttaatggta cttaatattt ggagcttttg agtccattag  13141 atcaggtagg attgttcgtt attttttttt tttaggaaga ctagaaatat gttgctccct  13201 ttttctcccc cactcaagct tgatggtggg aattggccct ggagcbgttt actgtcagtt  13261 cctgtccagc ttcactaaat ttggtctggg gtcacatctt agcbggggac tgtggggttc  13321 tgtggtccct tctcgacttg gcccagctcc acttgaatga tattgttgtc aaattgctat  13381 aatagaatcc agttgatgga cagactatcc aatgaatcca ttatgttggt ggtggagctg  13441 gtgcaaagag ctccagagca gctgctggca ctgacccccc tccaccaggc agccctggca  13501 gagagggcac tacaaaacct ggtaagagtc caccctacca gactcagatt tgctgccctg  13561 ggcaattctt gctcctcaga caatgctctc tgactgtcct ccaaccctct acttcttgct  13621 ttcttgctgc caaacaggtt cctgtctaca aggcctggcc cgttttgcct ctgggttctg  13681 ttccttgata atatgcttca cgttacttgt ccatacctct tggagtccga gaaatctctt  13741 ggagtccacc tctcagtctt tctgcctgct cctatctggt ctcattgctt aagaaagtga  13801 acaaaggtag tgagcatcat agggtgctga gttgggagca ggagggaggg aaggtcaggg  13861 ggcttggtgt cttgatcaag gtgtctggta ttctgagtca gaagtgcatt gtccaagttc  13921 tgatgctctt ctccaggctc caaaggagac tccagtctca ggggaagtgc tggagacctt  13981 aggccctttg gttggattcc tggggacaga gagcacacga cagatccccc tacagatcct  14041 gcbgtcccat ctcagtcagc tgtaaggctt ctgcctagga gagacatttg ccacagagct  14101 gggatggctg ctattgcagg agtctgttct tgggtatgga tcttcgagaa cttcagattc  14161 taactcattc tatacccagt ccctcagcca ccatcatcag tggcagcctg ttccatattc  14221 ctaagggccc ttggagccct gtgtccgaaa tcctagcatg tcctcttttc cccttccttt  14281 tcctcacagt tccctcagct ccccagcccc cgattttctt cctgtcccca ggaaaccaga  14341 gttgtggagc caggatgaag tagagcaagc tggacgccta gtattcactc tgtctactga  14401 ggcaatttcc ttgatcccca gggtgagatg aaggaagaag ggaagggagt aaatgcatag  14461 aggggactgg tgagctggtt atggggaccc gtggccaacg agggcaaagg atatgaagcc  14521 tagatctggg gggatactgc gaaacagaga caggactttg gacttatagc tatagcagca  14581 ggtcctgatc tgtccagatc tccccactct ccttctacct tctcatgcag gaggccttgg  14641 gtccagagac cctggagcgg cttctagaaa agcagcagag ctgggagcag agcagagttg  14701 gacagctgtg tagggggcca cagcttgctg ccaagaaagc agccctggta gcaggggtgg  14761 tgcgaccagc tgctgaggat cttccaggtg aaactaccca aatacttata tgtccagcag  14821 gatgtacagg gagtatcaaa cggtctgggt tctacatgtg cttttctctg ggactgggtt  14881 ttctaattta taaagcaaag agtttagagg gatgatcttc aagtctcgtc tagttctaaa  14941 attctatagc tctgggagtg tgtaaactat taagttttcc tttagcccag aacttccatt  15001 ttcctgctgt cttgtctctt taaacagctg actcagctct agctcggcta agtgtggagc  15061 tctctgctgg ggagatccct cgaaggagac attgtgaggc tagagaactg gtttcaaatt  15121 cagctctgcc atgaaatccc tgaccaacat cctcagtctt ccatctataa aatgagggac  15181 ttggcatctc caatcacttc ttgttcaatt cacttctaag ccctatacat cttaacctgt  15241 aatactccct cgatccctac ttcccacagt gctccatcct ccaaaggttg gaagagtcat  15301 tccatctaca gatacctcct ggccctgcct tcccccttca gaacctgtgc caaattgtgc  15361 agatgtacga gggacattcc cagcagcctg ctctgcaacc cagattgctg agatggagct  15421 ctcagacttt aaggactgcc tgacactatt tgcaggagac ccaggacttg ggcctgagga  15481 accacgggca gccatgggca aagcaaaatg ggtcagggac ggagagccaa ctgaggttgg  15541 ccatgaggaa gctgtgtggg tgtgatgtag gacacgaaga gaatagagag ttggatgaga  15601 ggtgggggaa gcagaagata aaagagttag aagatttggg tcacaagtag aaggtgagga  15661 gagataaata ttgaggaaag agagctacta taatgaatag agggactaaa gcagtgatta  15721 ccaaatttta atgcatatca caatcatcaa gggaacagat ttttttcttt tttctttttt  15781 tttctttctt aaaaaataat ggcatacttc atgaatttgt gtgttatcct tgcgcaggcg  15841 ccatgctaat ctctgtatca ttccaatttt tttttgtata tgtgctgctg aaccgagcac  15901 gggaacagtg ccaatgctgg attaccatgc tagactgact taataaaaac ctttgcggag  15961 gctggacgga gtggctcgtg cctgtaatca cagcactttg ggaggctgag gcaggtggat  16021 tgcttgagcc caggagtttg agaccagact gggcaacatg gtgaagccct gtctctacta  16081 aaaatagaaa aaaaattagc tgggtgtggc ggcacatgcc tgtaatccca gctactcagg  16141 aggcbggggt aggagaatcc cctgagcgca ggaggtggag ggtgcaatga gccaagatca  16201 caccactgca ctccagcctg ggtgtcagag caagaccctg tctcataaat taaaaaataa  16261 gcctctggga gaaagtctag acatctgcat ctgctttttt tttttttttt ttttttgaga  16321 cacagtctca ctctgtcacc cagcatccag gctggagtgc ggtggtgtga tcttggctca  16381 ctgtaacctc tacatcctgg gctcaaacga tcctcctgcc tcagcctctc gagaagctgg  16441 gactacaggt gcacaccact acacctggct aatttttgta tttttggtag agatgaggtt  16501 tcgcbgtgtt gcccaggatg gtcttgaact cctgggctca agcattcctc ccacctcagc  16561 ctcccaaagt gcbgggatta cagctgtgag ccactgtgct gggccccagg catctgcatt  16621 ttaataagcg tctctgtgtc tgatgcacat aaaagtgtgg aactcatgga ctagagttag  16681 tttgctcttc ttttccactg attgtaatgt ctttcaaaac accttagagg aactgtaagg  16741 caacggtctc attttatagt ggaggaaacc aaagaaaagg caagtgactt gcctagagtt  16801 atacagctaa ggtcagaggc aagacttaaa acccagcatt ctgactccca atctactggt  16861 tttccactca cattgttcct ctctttctcc tagttgtggg gtcccccccg gggatttggt  16921 cctgagcaga tcctgcagct cggtagactc ttaataggtc tgggagatca ggaactacag  16981 gagctgatcc tagtggactg gggagtgctg agcaccctgg ggcagataga tggctggagc  17041 tccactcagg taacactttt actcctccct accgcttccc aaacacccat cccacagacc  17101 cagccctata gatcatctaa agcccaagga attttttcct gtgaccctac ctggtcattc  17161 tttctgtctt ttgttaatat cccatactag tgaccttcag gactcttgat ttattcactc  17221 tgaggccctg gacacataat actgtctcct acctcttttc ctggaggctt cctctttttc  17281 tttccttttc ttttctgagt cctcagcctt ccccatgact ccttaggtct taatagtaac  17341 agaatataac ccagtaacac ctatcacttc cctgtccatt aattctccat aactttcctc  17401 cttcccctct tctcccaccc cccaccccag ctccgcattg tggtctccag tttcctacgg  17461 cagagtggtc ggcatgtgag ccacctggac ttcgttcatc tgacagcgct gggttatact  17521 ctctgtggac tgcggccaga ggagctccag cacatcagca gttgggagtt taggtcattt  17581 gtgaaggggc tgagggtggt cgtgttcagg taaaggtgga cttgcbgggg aaaggaggat  17641 catgaagtta tagtcccatg gaggaaggga actcatttga agccatctct tcctttgtct  17701 catgaccaca gtccctttca ctgaagccga attcttcttc cttccttccc actgttctac  17761 agccaagcag ctctcttcct gggcaccctg catctgcagt gctctgagga acaactggag  17821 tttctggccc acctctttgt actgcctggt gggtttggcc caatcagtaa ctgggggcct  17881 gagatcttca ctgaaattgg caccatagca ggtggggagc tgggccactg ctggtgcaag  17941 ttggtttggt ttctatacca tgggtggact ggatggaaga ctgccctgca attcttcagg  18001 tgtgggcctg agagggtgtt taaataaggg gctagagaca tattggggaa ggtctatgat  18061 agggcacttt gggagtagtt agagaaggtc tataggtttg aagagaggga aggtcagtct  18121 aagacaatgt ttggatgcca cttgcttcaa cagcbgggat cccagacctg gctctttcag  18181 cactgctgcg gggacagatc cagggcgtta ctcctcttgc catttctgtc atccctcctc  18241 ctaaatttgc tgtaagtatt aatggactgg ggtgaccaca ggagagccag ggcccaatgg  18301 ggactacatg catgcactga ttcctacccc tgccctcagg tggtgtttag tcccatccaa  18361 ctatctagtc tcgccagtgc tcaggctgtg gcbgtcactc ctgagcaaat ggcctttctg  18421 agtcctgagc agcgacgagc agttgcatgg gcccaacatg agggaaagga gagcccagaa  18481 cagcaaggtg agttcccagc tgcacagctt gatcctccat ctcctgaccc agaatcaaac  18541 ccctaatttg gtgcbgtctg gctcttagag tgcacccagg gagatccctg gagtgaagga  18601 gtctacaggc agagcgctaa tttccaagta tcaatgctcc tggagagctg agttgtgata  18661 ttactcccat tccctgtcta ttataggtcg aagtacagcc tggggcctcc aggactggtc  18721 acgaccttcc tggtccctgg tattgactat cagcttcctt ggccacctgc tatgagcctg  18781 tctctacagt agaaggagat tgtggggaga gaaatcttaa gtcataatga ataaagtgca  18841 aacagaagtg catcctgatt attttcagaa gctgatgagg aata 

Clarin 1 (CLRN1)

[0156] The CLRN1 gene encodes “clarin 1” (CLRN1), a protein that is expressed in hair cells of the inner ear (e.g., inner ear hair cells, outer ear hair cells) and in the retina.

[0157] The human CLRN1 gene is located on chromosome 3q25.1. It contains 7 exons encompassing ˜47 kilobases (kb) (Vastinsalo et al. (2011) Eur J Hum Genet 19(1): 30-35; NCBI Accession No. NG_009168.1).

[0158] Various mutations in the CLRN1 genes have been associated with Usher syndrome type III (e.g., Usher syndrome type MA (MIM #606397) (see, e.g., Fields et al. (2002) Am J Hum Genet 71: 607-617, and Joensuu et al. (2001) Am J Hum Genet 69: 673-684) and retinitis pigmentosa (see, e.g., Khan et al. (2011) Ophthalmology 118: 1444-1448). Usher syndrome type III-causing mutations have been predominantly found in exon 3 of CLRN1. Usher syndrome type III-deafness can be modeled by generating CLRN1-deficient mice (see, e.g., Geng et al. (2017) Sci Rep 7(1): 13480). Exemplary mutations CLRN1-associated with Usher syndrome type III include: T528G, M120K, M44K, N48K, and C40G.

[0159] Exemplary mutations CLRN1-associated with retinitis pigmentosa include L154W and P31L (see, e.g., Khan et al. (2011) Ophthalmology 118: 1444-1448).

[0160] Additional exemplary mutations in a CLRN1 gene that have been detected in subjects having hearing loss and methods of sequencing a nucleic acid encoding CLRN1 are described in, e.g., Fields et al. (2002) Am J Hum Genet 71: 607-617, Joensuu et al. (2001) Am J Hum Genet 69: 673-684, Adato et al. (2002) Europ J Hum Genet 10: 339-350, Aller et al. (2004), Clin Genet 66: 525-529. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

[0161] An exemplary human wildtype CLRN1 protein is or includes the sequence of SEQ ID NO: 39, SEQ ID NO: 41, SEQ ID NO: 43 and SEQ ID NO: 45. Non-limiting examples of nucleotide sequences encoding a wildtype CLRN1 protein are or include SEQ ID NO: 40, SEQ ID NO: 42, SEQ ID NO: 44 and SEQ ID NO: 46.

[0162] In some embodiments of any of the compositions described herein, the CLRN1 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 39.

[0163] In some embodiments of any of the compositions described herein, the CLRN1 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 41.

[0164] In some embodiments of any of the compositions described herein, the CLRN1 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 43.

[0165] In some embodiments of any of the compositions described herein, the CLRN1 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 45.

TABLE-US-00014 Human Full-length Wildtype CLRN1 Protein Isoform D (SEQ ID NO: 39)  MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGV  RQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSF  ISVALWLPATRHQAQGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHF  LNGLLIRLAGFQFPFAKSKDAETTNVAADLMY  Human Wildtype CLRN1 Isoform D cDNA (SEQ ID NO: 40)  atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagt  tgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtca  atgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtg  aggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagt  gagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttct  tcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttc  atttcagttgccctttggctgccagctaccaggcaccaggctcaaggctcctgtggctgtcttgtcatgat  attgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatg  tctacaaaacgcaaagtgaaaaatataccacctcattctgggtcattttcttttgcttttttgttcatttt  ctgaatgggctcctaatacgacttgctggatttcagttcccttttgcaaaatctaaagacgcagaaacaac  taatgtagctgcagatctaatgtactga  Human Full-length Wildtype CLRN1 Protein Isoform A (SEQ ID NO: 41)  MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGV  RQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSF  ISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHFLNGLLIRLAGFQF  PFAKSKDAETTNVAADLMY  Human Wildtype CLRN1 Isoform A cDNA (SEQ ID NO: 42)  atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagt  tgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtca  atgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtg  aggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagt  gagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttct  tcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttc  atttcaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcaga  aaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattct  gggtcattttcttttgcttttttgttcattttctgaatgggctcctaatacgacttgctggatttcagttc  ccttttgcaaaatctaaagacgcagaaacaactaatgtagctgcagatctaatgtactga  Human Full-length Wildtype CLRN1 Protein Isoform C (SEQ ID NO: 43)  MQALQQQPVFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSC  GCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWLTKGHS  Human Wildtype CLRN1 Isoform C cDNA (SEQ ID NO: 44)  atgcaggccctgcagcagcaaccagtttttccagatttgctcaaagcaatcccagtgagcatccacgtcaa  tgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgctt  ttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcaggctcctgt  ggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaatta  taaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctggctgactaaaggcc  acagctga  Human Full-length Wildtype CLRN1 Protein Isoform E (SEQ ID NO: 45)  MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGV  RQCGLGARPFRFSCYFLDPFMGLPTGVPHLLSLPCSTSCRREHTSERVQEPAGCFSAVRSKLHAGPAAATS  FSRFAQSNPSEHPRQCHSLLCHPYCVNHGGDSLLHVQCFWKTF  Human Wildtype CLRN1 Isoform E cDNA (SEQ ID NO: 46)  atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagt  tgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtca  atgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtg  aggcagtgtgggttgggagcaaggccctttcggttctcatgctattttcttgaccccttcatgggactccc  aacaggggtaccccatttactcagcctgccctgctcaacctcttgcaggagggagcacacgagtgaacgag  tgcaggaaccagctggctgctttagtgctgtgaggagtaaactccatgcaggccctgcagcagcaaccagt  ttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatcctta  ttgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttga  Human Wildtype CLRN1 Genomic sequence (NCBI Accession No. NG_009168.1)  (SEQ ID NO: 47) 1 aggagatact tgaaggcagt ttgaaagact tgttttacag attcttagtc caaagatttc  61 caattaggga gaagaagcag cagaaaagga gaaaagccaa gtatgagtga tgatgaggcc  121 ttcatctact gacatttaac ctggcgagaa ccgtcgatgg tgaagttgcc ttttcagctg  181 ggagctgtcc gttcagcttc cgtaataaat gcagtcaaag aggcagtccc ttcccattgc  241 tcacaaaggt cttgtttttg aacctcgccc tcacagaagc cgtttctcat catgccaagc  301 caacagaaga aaatcatttt ttgcatggcc ggagtgttca gttttgcatg tgccctcgga  361 gttgtgacag ccttggggac accgttgtgg atcaaagcca ctgtcctctg caaaacggga  421 gctctgctcg tcaatgcctc agggcaggag ctggacaagt ttatgggtga aatgcagtac  481 gggcttttcc acggagaggg tgtgaggcag tgtgggttgg gagcaaggcc ctttcggttc  541 tcatgtaagt agcaattgca tttgagttat ttaatgcttt aggcagactc ttcccagtgt  601 tgcgaggaat tatatttgag aattttgccg tgtttactgc aggacttttt aaatcggtgt  661 gaaccatatg aaaaacctat gactctgagc aatttcttct tcctagtttt tattatttta  721 tacttgcttt ttattataat atagagttaa ttcattgtta cataattaag gtttttggaa  781 atattggcaa ttaagatgct taagtattaa tatttatgta aaaaattatg gagtcttttt  841 aaaaaagtaa acttggggaa ataggaaagc tgtaaagaat gatctttatg ctttttgttc  901 tttataaaaa gaaccaaggt catgggctcc gtatttaacc aggttgccac ctttctcatg  961 attttgtttc ctgctcccca ctccctccca ttattcctgc taagaccttt cctgctgcta  1021 aatattcagt tttcattttt aactaatttg gaatcatttg gctatagaaa tttaaaatga  1081 tctgcbgtgc taactgggaa agaaatggat gcctatttag tatagaacat tttaaactga  1141 ttgacctgca aatcatgtag agaatatgag agagattttc ttgttgtgat ttttgtgaaa  1201 tggaagtgta atccacagta tttataacct gtttatctta agaagagaat ttttaaaaat  1261 taccatgtga ataggcaact cattaaatga aaattaatag gaagtcattt gttatatctc  1321 ttacaacaca cattcagaag ttattattat ttcagaaggg ctggtttgga acaaccttat  1381 gaagacacag tcagtaaatt actgcataaa tcactcttca ggaaaggagg ttaccaactg  1441 aagcatttaa aatgaattat tattttgccc aggttttttt tttctttcta gtataggtag  1501 aaggctaaat taattgaatt tattattaac atatgcagtg cctaattaaa tttcagtgct  1561 ggtctattta tatttctgca acattcctta tatcttctta gcagtcattg gacaccaacc  1621 ttcagctcac ataggttact aagtgatatg aattttcata gggctccaga aaatttccaa  1681 gaattggttg ttagcttttt aattgatgaa gtggatacca gttcttttca ctgaatggct  1741 tttattcatt aaggtaatgg ggcbgttaga gttgcttagt tttcctgggg aaggggaagg  1801 aagaaaacaa agcagaatgt catgtgatat gcaactgtat taaaaaaccg aaaaggaaaa  1861 aagttgagag agatgattta accgtgagtc accggcagcc aaagcgtgag taaagcttct  1921 cacagatgaa tttagacaaa agcggagaag gtactggtga attttctgga gcctttacat  1981 tttctacagt gaaatggaga taaactttac tcatgccata ggacatgttt caaaacaata  2041 ataagatgtt ttctgaacac ttactacata ctaagcactt tatatgcttt gtctcattta  2101 atccttacac agccacattc ttctggggtt tagcgaatga tttttgtggt tgtgtcctat  2161 gcttgtcctg tctaaggatg aagttgttct aattgggtgc ccctcctttt gctttctgtg  2221 aggacttgca gaactggtgg ggtttaaaca gtaccctcac ttatctcaca gaatttcatt  2281 agctcccaga tacccctgac attctccccc tagcctagtg aagaaaatct tccatttact  2341 tgttcattct gcagtgacag ctccatcaat atacaataga ctatacatat taagtgtact  2401 gtatatacta tacatgttaa aaatctcatt cattttggtg aggcccagct aagaatactt  2461 acagtagagc tttttttttt ttcctaagca taaaagtatc tttttcaatg cagcatgaga  2521 cagagttggg aaaaccaaaa taaatagatc caatggactc cccaaagagg ataatattca  2581 tttaaataaa cacccctctc agtgttaaaa ctttctaatc aacatgcctt tgggacacat  2641 tgcaccctca aagtttacac tcccattgca acgcagcttt gtggttcacg ttttttccat  2701 tcagaatgtc attaccctgt caatgatgtt tcatcaacgt ttgcttggat gagaatcctc  2761 tgatattctt cctgatagaa atgtataagc cctgttcata taaatgaata aaagatctaa  2821 ccttactttc tcagtagtgg cttccttgga gcaaaaagca gggacctcca gagagctcag  2881 gtggatgact cttttctgtt tcttccagag ctcaacttac aattagtgca caattcattt  2941 cccagaatgt cttctttctt attgtgcctt tagaaagtta ttaagcaaac atttgaattc  3001 acagaatctt accagtgtaa gaggaatgga aaaggtaact tatcaaggta acaatcactt  3061 cgtggccagt tttttcggct cactgcaact acccctcctg ggttcaagcg attctcctgc  3121 ctcagcctcc caagtagctg ggactacagg cgtgcaccac catgcccagc taattttttt  3181 tttgtatttt tagtaaagac agggtttcac catgbgggcc aggctggtct catggcaagt  3241 tttctttgtg ttgtcatgtt attatcaatt aataggaatt tatatttcag ttctgttagg  3301 tggataaaca ctattttgca tacctaaatg tttcatttat atcagcactg gccaataaaa  3361 atatactata agcaggccgg gtgcagtggc tcacgcctgt aatcccaact tttgggaggc  3421 caacactttg ggaggacaca gggtcaggag atcgagacca tcctggctaa cctggtgaaa  3481 tcccgtctct actaaaaata caaaaaatta gccgggcgtg gcgggggcgc ctgtagtccc  3541 agctacttgg gaggctgagg caggagaatg gcacgaaccc gggaggtgga gcttgcagtg  3601 agccgagatc tcgccactgc actccagcct tggtgacaga gcaagactct gtctcaaaaa  3661 aaaaaaaaaa aaaaaaaaaa aaaaaatata tatatatata tatatattac aagccacaag  3721 ccacatatgt acttttaaat gtcctagtag ccatattaga aaacaaaagt aaaaaggaat  3781 agatgaaatt aattttaatg atttttttaa acccaagata tccaaaatat tatcatttta  3841 acatataatt aaaaatttat tgagatgttt tacattgttt ttttttttct tgacgctgtc  3901 ttggaaatct agagtgtatt ttacatttac attacatcta attcagtcta gccacatttc  3961 acatgctcat ttttttgtgt gtggttttat ggagcagaga gtttaatagg caagaaagaa  4021 aagagaaggc agaagaaaat ggctcccctg tacagagacg cgggggtggg gcgctccaaa  4081 gccaaaagag gaggtcccta agtatggtag acaccagcca ggaatatatg cagtgtctgg  4141 aggaggggat gtctgatttg catagggtca catgctcatt tttatggcta ctgtattggt  4201 cagtacagat ttagatgggg atttgctctg aacaagttgg tgattgatgg tgttcatatt  4261 ttaattgaat ttttcctggg ttctgctgta cacttgtatg tgtgttagtt tcatgtgcaa  4321 tgcttgtgtc acttttaaaa cccagatata tggcataaca tgagaatgaa aaatggacca  4381 gaaaaatagt ttggcaatgt agtcatgttt gttcctatta aatgttccct attgaccact  4441 ctatctcttt taattataac aagaatctgc cctgccagca tgcccagtta cgctgggaaa  4501 acttctgcct catttactct ggctgattct catccactta tgggtcagtg gttcattttc  4561 tagaggtcac cagcattcat acctagcata caatttcatt cattataatg aaggaatgtt  4621 ttcccttcaa agagacacaa ctagtgggct taatttttct tgatatgtca cctgtaaaat  4681 tttaatgatg atgtttaaac tctaaatgta gccatcaaga caaaaactgc aaattttgag  4741 cctcagtgtg tgtgggtggg tttctgtttc ggtaatttga aacattgcag aatatcatca  4801 aaatatgata cccaagaatc atatggtatc aatcattcct agatatactg atctattcat  4861 tgccaagata gttcaatgag ctggcaaaaa catatggaat tattttctta aaatgtgaaa  4921 aataaaattt aaccaatcat gtatcacagc ttgcaacttt agtcatactt tgaaaagcat  4981 tttaatttgg acctcatgat tgaaaattta taaaaagctg aacagaaatt agttcacttc  5041 atattttaga aaagcagagt ttctttacta aatgaggcat ttgacccaaa ttggagagaa  5101 aatgttgaaa ctacttctgt gagcaagcag gtggcttctc aaacacatgt tgggatgaaa  5161 tggttgggcc tcagggtctc agtgcctgtc actgagagtt ggcactctct atctccatgg  5221 tctcctccaa gtgtgactct tgtctcttgc tgacctgacc tgccccaagt gactcactgg  5281 tcatgaccct gcacaccttg cgtctctcct atcaccctgc cgatggcaga gctacaaagg  5341 tctttgatgt agctctgtct gatatcctgt gtttccccct atggtctgtg tggaagcagg  5401 tatgggggtg tgtaaagggg aagcctatga agttcatctg caaagactac ctggttaggg  5461 gaggagagga agaagctata tgcaccattt caccagcaag catgggctct tctgcctttt  5521 agcttagggg tcctgttgtc tagtctcact cacctattaa aacagtccag caaatagagg  5581 ttttgtttac ctcccattaa aaaaaaagca attaatggaa tagaagataa taatgtatga  5641 gaagcactat tgtgaaagaa aaaccttcaa cttctctcag ccaaataatt gcttcctcct  5701 ctgtccttcc cagaccttga tgtttgctct attatttcaa aacaactata ttataaatat  5761 ttgagaatgt gtatttccct gcaaggagat cttaatcccc aagaaggcag gagctgtgta  5821 ttattcatcc cagtgctcct tcaaaccagg gcctcagaca gtgcatggcc caaagaggta  5881 cttaataaac gtttggtaaa ctgacactat tgaaattaag caacctggat ttgaggtggg  5941 tctctgccac tcacaagaga ttacgctttg agaaaattcc atcacttcat tgattttcag  6001 ttcttgcatc tgtatatggg agacgatact aggtgatttc tgacatctct caccgtttaa  6061 atgctctgtg atctatacaa cgaggggctc gcbgttctag acaagttcct tccagcttta  6121 cagttgcata acccttctaa tcttagtcac atgatgactc cactgacaga tttttggcca  6181 ccatcattag acatgctgag ttacgtgtgc ctttgctctg atcctcaaaa ctcatgattt  6241 ttaaagtttt ctgaaatatc taccatttat caggatccag atggatttca tgaccaaagt  6301 ggatgtttct tttctctccc attacaatct tttacttttt gtgtgggaaa ttgcatgtta  6361 aagaaaggga aattgaagaa tgggatgctt tggaattctg gcaagatgga ttagtgggtt  6421 ccagaaagta ggggcagcca caaataccga aataaatgag atcgtattat tgagaaagca  6481 caaatggaag aaggtcaaaa gcaagaagaa gctgacatcc tgcttcctcc aatttttgct  6541 ttctctgttt ttccaagaaa ctcctcttcc aagccttgct gaaaaactcc actttcctaa  6601 atctaacttc ttaaactgat aatggcaaga agttaggaat gaccaatatg tttaacactc  6661 caagagtatt tgttttgttt tgttttgaga ctgggtctca ctctgtcgtc cagcctggag  6721 tgcagtggtg tgatcacagc tcactgcagc cttgacctct cctgcccaag gaatcctccc  6781 acctcagcct cctgagtaga agggaccaca ggcatgtgcc actacacctg gctaactttt  6841 aaaaaatttt tttgtagaga tggggttgcc caggcaggtc tcaaactgct gggctcaagc  6901 aatcctcctg cattggcctc ccaaagtgct ggaattatgg gcataagcca ctacgcctga  6961 cctctccaag ggcattcttt acccagaaga ggaacttggc agaacttatc ctccaattgg  7021 tgaggaatat ggagaaaatg actttaagca aaggaacttc tggttctgcc tacctaatcc  7081 agaaaaagaa gttttatttc tcccttcccc tagtaactat cttcccatat tcacataaaa  7141 aagtacagaa tcaacattgt tcaagaatta taattttact tgtaagcaca tgtgcacacg  7201 cacacccata taccttcctt ccctttaaat catcccacac cctaatagta gtaaaatcat  7261 tgacccgagc atacctggga gaggaagagg agtctgacag gggcaggttc taagtggcac  7321 tcctggaact taaccctggt gtatatgaac tttacctatt gaaggatgac tcctcaactg  7381 ttctcacaat ttgctgctct gctttctttt ctaatttctg aaggtgactc atcttcccca  7441 aggactttca gacttctcag aagaaaaaaa tattgggtgg gtctctgcca ctggcaaaag  7501 attagacttt gagaatcata aaagtatatc agtatatact cattaatatt gaattactat  7561 aattaatatt atgatattga tataatgata gaatgatatt gataaaagca atattcaata  7621 atgaatatta tttcagctgc ccacttattg ggtgcctcat aggtgccagg cattttgtat  7681 gtattatcta caacccttac atgggacata ttatgatgct gtttctcttg aagaaatatg  7741 gaaactggaa acagagaggt caccacaatt ttccaaagtc acatagctaa taggtagcag  7801 acttgggatt caaattcata tgcatatggt aaatcatgct cttcctctgc tacattttgc  7861 ccccttagaa tatgaaaaag ggatacaaag agatgaagaa aatatgtaag attatccttc  7921 aatttcacta tcttttttaa agtttttttt attatacttt aaattctgaa atacatgtgc  7981 agaacatgca ggtttgttac ataggtatac acgtgccatg atggtttgtt gcacccatca  8041 acctgtcatc tacattaggt atttttccta atgctatccc tcccctagtc ccccacccac  8101 cgacaagccc cggtgtgtga tattcccctc cctgtgtcca tgtgttctca ttgttcaact  8161 cccacttatg agtgagaaca tgcggtgttt ggttttctgt tcctgcgtca gtttgctgag  8221 aatgatggtt tccagcttca ttcatgttcc tgcaaaaggc atgaactcat tttatggctg  8281 cataccattc tatggtatac atgtgccaca ttttcttaat ctagtctatc attgatgggc  8341 atttggctta gttccaagtc cttgctattg tgaacagtgc tgcaataaac atatgtgggc  8401 atatgtcttt atagtagaat gatttataat cctttgggta tagacccagt aatgggattg  8461 ctgggtcaaa tggcatttct ggttctaggt ccttcaggaa ttgccacact gtcttccaca  8521 atagctgaac tagtttacac tcccaccaac agtgtaaaag cgttcctatt tctccacatc  8581 ctctccaaca tctgttgctt cctgactttt taatgattgc cattctaatt ggagtgagat  8641 ggtatctcag tgtggttttg attagcattt ctttaatgac aagtgatgat gagctttttt  8701 tcatgtttgt tggccgtata aatgtcttct tttgagaagt gtccgttcat atcctttgcc  8761 cactttttaa cggggttttt tcttgtaaat ttgtttaact tccttgtaga ttctggatat  8821 tagtcctttg tcagatgggt agattgcaaa aattttcttc cattctgcag gttgcccgtt  8881 cactctgata atagtttctt ttgctgcgca gaagtttttt tagtttaatt agatcccatt  8941 tgtcaatttt ggcttttgtt gccattgctt ttggtgttta gtcatgaagt ctttgcccac  9001 gcctatgtcc tgaatggtaa tgcctaggtt ttcttctagg atttttatgg ttttaggtct  9061 tatgtttaaa tctttaatcc atcttgagtt aatttttgta taaggtataa ggaaggggtc  9121 cagtttagtt ttctgcatat ggctagccag ttttcccaac accatttatt aaatagggaa  9181 tcctttcccc gttgcttgtt tttgtcaggt ttgtcaaaga gcagatggtt gtagatgtgt  9241 ggcattattt ctgaggcctc tgttctgttt cattggtctc tgtatctgtt ttgatacaag  9301 taccatgctg ttttggttac tgtagacttg tagtataatt tgaagtcagg tagcgtaata  9361 cctccagttt tgttcttttt gcttaggatt gtcttgacta ttcaggctct tttttggttc  9421 catatgaaat ttaaagtagt tttttctaat tctgtgaaga aagtcaatgg tagcttgatg  9481 ggaaaagcat tgaatctata agttactttg ggcagtatgg ccattttcat gatattaatt  9541 cttcctatcc gtgagcatgg aatgtttttc catttgtttg tgtcctttct tatttccttg  9601 agcagtagtt tgtagttctc cttgaagagg tccatcacat cccttgtaag ttgtattcct  9661 aggtattttg ttctctttgt agcaattgtg aatggaagtt cactcataag tttgctctct  9721 gtttgtctgt tattggtgta taggaatgct tgtgattttt gcacattgat tttgtatcct  9781 gagactttgc cgaagttgct tatcagctta aggagatttt gggctgagac gacagggttt  9841 tctaaatata caatcatctc atctgcaaac agagacaatt tgacttcctc tcttcctatt  9901 tgaatacgct ttatttcttt ctcttgcctg tttgccctgg ccagaacttc caatactgtg  9961 ttgaatagga gtgttcacca cctattttaa gaatagtatt gaagcctcac aaaagctggt  10021 tctcatgtaa ccatctgaga atatttggcc ttatgacttg aattcattca ttgccttttt  10081 atttcacatt ttagtgatcc tgatgtctaa atcttaatct ttgatccttg caaggtaaaa  10141 tagccaagtc aagcctgttt aataatattg gttgaggaag tcacatgctt atgatcaatc  10201 tttgggttat gtaattatat taccttaatg ttggcagttt aggtgtaagg cagagatatc  10261 tgatcacatg tgtggttagc taatttaaga tcactgccaa ctaaaatctt catggtatga  10321 tcttcaaagt tagctacttt gaccacagca atgatttcac cacagcaatt aacaaaatgg  10381 cagactcttt cctgaggtgg catgaacagt tttaaaacaa agtcaaggac caaaagaaaa  10441 gcaggcacat ggcatttgat tcatttcaaa aactagtatt gtattaagag ccaaggggat  10501 agaattgtag catcaattaa aatcttgttt gaaaaaaaat aaaaacaaac gtccattttt  10561 atctctcaaa tatattaggg ttttcataaa gttataggtg tatttttaaa aaaacaaaac  10621 tcatatacat tagactgaaa aatttgcctg tcatctcatc atgcagctaa atgcaattgt  10681 ctatggcgag atacactctt attagaggta tgatagcact aactaatagc aaactttgta  10741 cctggtagtc taatttatgc agggttcata tttcgctccc tctcagcatg ctgtaactgt  10801 ggcaaagcca ttctcaggag ttattacccc aacataatca tacccctgtg gattaggagc  10861 agttaaatgg gtcctgttat cagagacaca tatgtgccac agccgcbgtc atccctaagc  10921 caccgtgggt gattaagact cactgatggg actacctctg aataggcttg agtgaggtgg  10981 atacacttca gctgagagaa attcaggtaa ggggctgaga aaatcagatt ttgaatggtt  11041 ttatcatacc atcaggtctc cttttaagtg ctggggtcat ggatttcatt caacctgacc  11101 acatagcctt tggaagcttg gctcaatacc tgagtgtgag attatgggtg atattaaagg  11161 agatgaatgc attgagctga tgtcagagaa tgtcttttac tggattttca taatgactgg  11221 ctgcagatgg gctgagggga aagtcagatc aagagcattt ctgtaagaag aaagaaatct  11281 tccctcttat tctctttcaa gaaaatgaat agctgagcac caagaggcca aatacttttt  11341 taaaaaacac atccttttat gtagagaagg acaggttgag acgaaaaaca ggacctctga  11401 aactgtcttt atagctttaa tctaggaaga aattgcggca ccattgctga catcattatc  11461 agaggctgcc ttagttctga gagcttcaca gatggccttt tctgcatttt acatctggcc  11521 agatgaaggc aaaaaggttg atgaaaccaa aactattaga tcagtggtcc ataactctgg  11581 ctgcacttta gaatcatctg gggagtcctt aaaactactg atcctgaggc tccatcccag  11641 accaattgaa tcaggatctc tgggggtggg acctgagcat tggaatgctt taaaagttcc  11701 tcagggactc taatgtgcag ccaaggctga gaatgactga ggtggatggt ggccaagaca  11761 ggtgaggcca agagttagaa gcccttactg ttagggaagg cagaagccac aaggaggagg  11821 ggagggggaa ggagcagtat ttagcatttc ttccacacag ttggggggtt ttctgatcaa  11881 aattaggctg ggatctttcg cttccatttt catgaaggtc ttatgctttg tccacagcca  11941 cctggcctca gggcaatgag caatctgatt gatgaatttt cagtaagaaa ctgagcacac  12001 ttggctctca gccccagtgg cttcccctgt ttccaaatct gcccaccagt tacaggagcc  12061 tgctcaccaa ctggttgggt taaagaagtc ggctctgtcc ttggcaggga ggccttcagc  12121 tgtctggccc tgtctgtgac tgcgtgggtg aagctgccta atttggggaa cttgatggaa  12181 gatctaagct atgttctcta acagttttat cagaaataaa gttaactttt gacctccatc  12241 tgcctgtctc ctgtggaagg gctctgctcc ttccaaagag actctcaggg gttctcctta  12301 gaggtgtgtt atcagtccaa agatcatttt agaccagcca ttacagagga tgtccaagaa  12361 attgcacaag ggaaatagaa gtaagaatga gagcaatata tcagatagta aggaaagtat  12421 gtgactggtt tcaaataagt aattaaccat aaatccaaag ttcctgcatt agttatagca  12481 atagtcatcc acctggtcag gaaaaaaaaa gtaaaagact gagctgcaag atagaaagtt  12541 tgcctgaatt ccacgtactt caaggactac tatggaggat tccttggtcc caatgcagag  12601 acatgtactc tgaccaccca tgggccaaat ccctcttacc caccctcagt gattcctcct  12661 gggacctcac tacattgagt tcttacattc cccactcttt tcgggggaaa tataaccctt  12721 ctgctcttct catgatgtta aaaatattta gacaattact taaaatttac aacaatcttc  12781 cacataaatg atctcactta tgtttcttgt gagctctgtg atttatttct attatcatct  12841 atgctgatag ttaaggaaac tgagatatcg agaccaacat gcatagtaaa tggcaaaacc  12901 agatgaattt taaactttcc taactccaaa agccacatcc tgcccaaccc gccatgctgc  12961 cgctcagtta atgcctggct gtttgtctcc ccattggccc ctctacccat tgtgctttga  13021 tggcacactg tattccaact gcctgagact cctggttaat gccattacgt acagacttag  13081 gttgaattta ctaggatttt taagatttgt aggataagag atatgactgt tagactggaa  13141 tcagcaatag ataaaaggtt aacaaagttt cagaataaaa tataatagaa aaccccagca  13201 gatagaagta aaatgaatgg taagacaact gaaatgaaag ccatacattt agaaatatca  13261 aataaaacac agattaatgg cagacaataa aggaacatac ttagcagtta gtaaaaacac  13321 tttttacctt attcttatta ccctccagta accttttttt tttttttttt tgagacaaag  13381 tctcgcbgtg tcitccaggc tggagggtag tgatgtgatc tcggctcact gcaacttctg  13441 cctcttgggc tgaagagatt ctcctgcccc agcctcctga gtagcbggga ctataggggc  13501 ccatcactgc acctggctaa tttttgtatt tttagtagag acggggtttc accatgttgg  13561 ccaggctggt cttgaactcc tggcctcagg tgatccaccc gcctcagcct cccaaagtgc  13621 tgagattaca agcgtgagcc accaagcccg gctgtaacct attgaaaata acattacttg  13681 acatgtgaga caaattattt gtaagttaaa gagtttatgt gccttcaatg ctcccaccct  13741 tccctcccct aaaaagatta ttgagtgccc atgatgtgcc taagccttct ggtagactct  13801 gagaatgtga agagagttag aggatacttg ttcaacaacc cagaatctag cagaagtgtt  13861 ttgaaatgac cagccacttg ggagagctat gctagcatat cattcaggat gggctgggtc  13921 atgttttaat aacaagtaag tttgaacttt ataggtttga aacaaaaaag atgtgtttct  13981 tgctcacagt tcatattttt tggagattgg ctggagcttc attccaggat actgccacca  14041 tctggaatgt tgacagttac cgtaacagag aaagagttgt ggaggcbgtc acactggcaa  14101 ttaaattcgc tgacctggaa ctgacacatg ccacctccac ttatatttta ttggccaagg  14161 cttgttacac agccacatct aacttcagag aggtcaagat gagcaaatcc taccacgagc  14221 tatagatgga tgagtagcac tcattattat cacaattatt ttatttgtta taaaaactcc  14281 aagaaggaga ggtactctat gtgaggaata ggcataggaa aatcagaggg aagttcttaa  14341 agatgagcta gatttcacta gatggcattg aagaaacatt ccaagtaaat gaacagcata  14401 agcaaatgca tgaagaactt attgtggtcc tagtacagac gatgcgtgag agtgtggagg  14461 agggaaaagg taagactgga gaggaaggca ggaaccagaa caggacagac tgtgttcact  14521 gtcaggcagt taagtctatc ttgtaggcaa catgaagcct tttaaggaag gcaagcagct  14581 atgtgacagg acagaagatg gattggaaga aaatcaaaag agaagtgggg accagtcata  14641 aggctcctcc aatatttggg gatccaaacc aaagcactgg cagagaaata gaaaggaagg  14701 gaaatatttc caaaatattc aaaacagaaa ccaagagaac ttgatgacag aagatgaacc  14761 caggtttcta ctgaatggac agttgttaca ttctctgaga taaggaatac agaaggaaaa  14821 agttgagagg gaatatgaaa ttatttttaa tcatgtttaa tttgatcact tgtggaacat  14881 caaccagaga tgtccatcag ttacaccaat ttgtaggttt tgagagaggc ctgaggtaga  14941 ggcagagaag tgggaatcag cagattagcg gcagtagttg gaaccataac tgaagatgag  15001 atttcccagg gaggggagtt gaacaggaag gtagacaaag gctgagtgca gtggctcata  15061 cctgtaatcc cagcactttg ggaggctgca gtgggtagat cacaaacaag atcaggagtt  15121 caagaccagc ctggccaaca tggtgaaacc ccgtctctac taaaaaaaca caaaaattag  15181 ccgggcgtgg tggcacacac ttgtaatccc agcctcagga ggctgaggca ggagaattgc  15241 ttgaacccgg gaggcagagg ttgcagtgag ccaagatcgt gccattgcac tccagcctgg  15301 gcgacagagc gagactccgt ccccaccgac cccctaaaaa agaaagtaga caaagatgtg  15361 tcctagaaaa cactaatatg aatgggtaga gaggggagac ttgtcaagga gatcgagggg  15421 agagtcagtg aggtgaaacc ttagaggata gaccttcacc aaggaagtaa cagtcaacag  15481 gcctaaatgc cacagagatg tcaaatgaga gacactggaa atggttcttt gaatattaca  15541 gccagaacat cacaggagac catttccaaa gcagtcttga tgaagtggtg gggaagggag  15601 gtccctgaag gagctaagga gggactggga gatcatgacc cagagataag tgttgcaggt  15661 ataaaaggga aagactgaga tcaggaaata gccacaggat ccctaaggcc aggcttcggg  15721 tggggtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tataaaatgg gaagaccttg  15781 agtataattc tgtactaaga agatagagca gtagagagga aaaggctgaa gacagatggg  15841 agggtaaata gtgaattaga aaggtctgtg caaagatgag aaaggatgag tctgaaagca  15901 cagggagaag ggccagcctt ggacaggaga aaacatttct ttcactaaga ataaagggaa  15961 ggttgggtat acaccacaaa gaaggtgtag atgggtggca atggagttct gtcaagttga  16021 gggcattcca tgatagcctc acctttctct gtgaaatgag agagtttagt ttacaagata  16081 tttctgagca cttcataagc caggttcata gactgaaaga agtggaggtg gagtgtgata  16141 ggtccttaag aataggggaa gtttggaata tctgacaagg gacagagagg aaaaaactag  16201 aaaaggcttt gcagaatgtg ggcccacaga tcagaggcta aggggtcccc atttgtgcag  16261 gagagtaagg gcagggaggc aaggctcaca gcccaaaata tagagcccct caccaaatga  16321 ctgcaggagg gcagctttcc tatgagagca tccctatcac tgttttcact ccgagtcatt  16381 aacttacgac ttactcagct ctgtttcgta atagcagact cgagtaatga gggtatgaca  16441 gcctctctct gcatgccaag gtatgcagcg tggatttcct ttttcgcttt ctctctcctg  16501 tggcttaggt gccttctgtt ctgctaccag gatagagaac ccagtgacta gtttcttcta  16561 gctctctttt tctgactagg tatcttgtca gaaatttctg cttaccagac ttcatggaga  16621 gggaatcaag ctttgaatca gggttgaaaa agtagagctt aatatatata ttacaaaatg  16681 ccactcacgt tcttgaggtt accttgtatc tataccacaa ctagcattct tttagaaagc  16741 accattaccg aagtaatccc tttcctggga attcacccaa aaaggttatt cccacttatc  16801 ccccatctcc aaaataaaaa agaaaaatgt gtgtgcttag agatgttcct ggaagcatga  16861 gctgtaatac tgaaccaata gaagacgaac taacagattg cagggcatcc gtttggcaaa  16921 aaacttatgc agttatctaa atgatagtta tgaagacaat atgtataaca cattatattc  16981 tgagtgaaaa gaacagaagg tgatttcaaa actgcattgg gataatagta atataggaaa  17041 tagtgagatg aacaaagatt tcaaaggaac aaaaataaag aaaaattttg ctttttatat  17101 tggtaggcgt atgggtgaaa ttccaatttt aattttaatt tcatagttat aaaattgttc  17161 ataaaaaaag gtcccccata gacagttggg ctttgggaca aactaacaga aacagagtag  17221 gaagaaaatt catcttcctt caatcccctt tctctgctta aaacaaaaca aaaaagagct  17281 ttgtcatgtt caggtgtgca acgaattctt tttccaaatc tggaacttta catctgctat  17341 taaacaggag tcagtttcca tgtaacatgt tgacaatccc ccaagtgtgt tggaataatt  17401 ttttttaatg aggagatttg aaattccatt tcaattgcca acctgcctct ttcaacttct  17461 aaaaacaaag taaaacaaaa caaaaacaca ctgggtccta tcaccccctc ttgctactac  17521 tattttatct ccattgccct gaattctttc caaacttctt tccacccagc tttgatttgt  17581 tttcagtcgg gtttattgag gcataattta cgtacagtaa aattcatcct tcttagattt  17641 agaggtctat gcattttgac taatgcatat tggcttataa tgactaccac aacaaagata  17701 tagaacacac ccatcactcc cgggttctcc ctgtcccttt tttggtccat ctcctctcct  17761 acccccaacc ccttggcaac cactgatctg ttttctgtcc ttatcatttt gctttttcca  17821 ggatgttgta tataaggaat catgcagcat gcagcctctc gagtctgact tcttccagtt  17881 agcacagtta tttaagatct atccgagtta ttgtgagtag cagcatcttt tttattgctg  17941 actagtattt catcacatgg atgggccaca acttgtttat ctgttcacct gtcaatggat  18001 actaagttgt ttccagtttt tggcaaatat gaataaagta aacatttgca tacagatttt  18061 tgtgtggaca catgttttca attctcttag gtaaatactg agcaatggga ttgctgggtt  18121 atatgttaag tctatgttca gttttctaag ttctgaaaca attggatatc tatatgcaaa  18181 aatacaaaat taaccttgac tcaaacttgt accatacaca aaaaataacc tgaaagagat  18241 cacaggtgta aatgtaaacc tagaactaaa aacttcaagg agagaaacat agcagaaaat  18301 atttgtgacc ttgcattagg caaagacttc ttagatttga catttgaaac atgatacata  18361 aaaaatcttg ataaattgga gttcataaaa ataagaacta ctcttcaaaa gacactgata  18421 agagaatgaa aatacaagcc acagacagag aaaatatttg tgaatttctt atctgataaa  18481 gggtttgtat ccagcatgca taaagacttt tcaaaactca ataataaaca atccaataag  18541 aaatgcacaa aagatacaaa cacatcatcg aaaatgacct atgaaaggca aataagccca  18601 caaaaaaatt ctcaacatca ttagacactt gggaaatgca aattaaaaca acactgagat  18661 aaactacata tctattaaat ggctaccact ttaaaaacct gtcaagtgcc agccagaatg  18721 tggaacaagt aggactctct tacattgcta gtgggaaggt gaatggtaca gccactttgg  18781 aaaacactcc gcagcttctt atagttacac ataggacctg ggggtagagg atggattgac  18841 tgtaaagggg caaaacttcc tggtaggggt ggggaaagtt tttagaaggg tgaaattgtt  18901 ctatatcttg attattgtgg tggttacaca actgtctgca tttgtcaaaa ctcacagaac  18961 tgtacactaa aaaggtatat ttttatgctc tgctaatttt actttaatct taaaaatagg  19021 aaggaaaaaa taaaatcaat gccactgtgc gactttgggc aagttacttc acttctctgt  19081 gccttggtct tttgaaatct atacattaag gataaaataa taccttcctc atactgttag  19141 aattaaatgt gctaatttat gttttatata tataaagtac ttggccgggt gtggtgactc  19201 acacctgtaa tcccagcact gtgggaggcc gaggtgggca gatcacttga ggacaggagt  19261 tcaagactag cctggtcaac atggtgaaac cctgtctcta ctaaaaatac aaaaattagc  19321 tgggcttggt ggtgcgtgct tgtaatccca gctacttgag tggctgaggt gggaggatca  19381 cttgaactcc agaggtggag gctgcagtgg gctccaccca ctgcctgggt gacagagcta  19441 gactccatct cgaagaaaaa ataagtactt gaaacatagc aaatgtttta taattattgg  19501 cttttttttc ttattgttat tacttgcatt attgcbgttt gaagaagttt ggtgataatg  19561 gagagaaaag ggcaattagg ggtctgggat ggtttaagta tgaggagacc gagacacatt  19621 gactcagagt gaagaaatca aagataagag aatgaaagaa agggagggta attctgaacg  19681 cacagacaaa gttatgttac taacgtggca tcggcbgtgt gttgtaataa ataactccct  19741 ttcacttgtc aatagctaat caaatacttt ctggagacca gaagtgactt gctggatcaa  19801 tgacaactcc tccacagatc aaaatgttca aatccttttt ctgtgttgta atcctaaatc  19861 taaaagaaca gagagaccaa gcaaatctac ctcccaacat cattaaagtg acaactctca  19921 gtatttattt gaatggtctg ctctcagctt caaccaagga aaagtcaaat tagtgttggt  19981 cagaaaacag aagggtgtta cgagagttct ggctggtcat tacagacttg gggatttttg  20041 attaaaagaa gaagaagaag aagaaacctg ataaagtgta aatatagcaa gcagggatta  20101 gtgtcctgct gggtcatgtt ctcacaacag tgagaatttc agagatttca taagaattaa  20161 actgctccac atgacaattt attttacctt ctggcttttc caggaggcaa atcagtgcaa  20221 cttctttctg cctttgtttc aatttggtaa caaccctcaa ttttaggaca ggctaaacct  20281 agccacccta tcagagatga tgaagtagcc atctttttaa caggtgggga gatgaatgga  20341 atcagggttt gtttgtttgt ttgtttaata actgctagta aaaaccaagt caatagctga  20401 ctgagtgtaa gggaggctcc agaaggcagg ttattgtagt atagatgtga ctcgacttat  20461 gatgatgtta cttcccgata aacccgtcat aagttgaaat atcgttaaat tgaaaatgct  20521 tttaatacac cgaatctacc gaacatcata gcttagctca gcctacgtta aatgtgctca  20581 ggacgcacat tgcctacagc tgagccaaat cacctggcaa cacaggacac tgtagagtat  20641 cggttgctgg cccttgtgat gctgtgactg actgggagct gcgcttagtg cctctaccca  20701 gcattgagag tttcttatcg cttattacta gcctgggaaa agaccaaaat tcaaaactca  20761 aagtgcggtt tctaccgaat gcttataact ttcagaccat catgatgttg aaaaatcgaa  20821 ccatcgtagg ttgggatcca tcctataaga cgagctacac tgccggaagt gtaagactgc  20881 tatgctgccg gaagatgggg catagtggac aactgcaagt cctgacaaca ggaggtcagc  20941 atctgcgacc tttaacatcc acattgacac taccacagtc ttccaaacag agctgatgat  21001 atagtttgga tgtcgtccct gcccaaatct catgtcgaat cgtaatcccc agtgttggag  21061 gtggggcctg gtgggaggtg attgggtcat gggggcagag ttcttatgaa tggtttagca  21121 cggtcccccc ttggtactgt atagtgagtg agttctcatg cgatctggtt gtttaaaagt  21181 gtgtggcacc tcccctctct ctctttctcc tactctggcc atgtgaagtg ttggctcccg  21241 ctttgccttc caccatgatt gttaaattcc cagaggtctc cctagaagct aatgctgcca  21301 cgtacagcct ggagaactgt gagccaatta aacctcatct ctttttaaat tacccagtct  21361 caggccgggc gcggtgactg acacctgtaa tctcagcact ttgggaggct caggcaggaa  21421 gatgatttga ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccatctcta  21481 ctgaaaatat aaaaattagc caggcatggt ggcgggtgcc tgtaatccca gctacttggg  21541 aggctgaggc aggagaatcg cttgaacctg ggagtcagag gttgcagaga gccaaaatgg  21601 agccactgta ctccagcctg ggcaatggag tgagaccctg tctcaaaaaa tatatatata  21661 ttacccagac tcaggtattt ctttacctga gactatgaga gaatggacta atatagctga  21721 agaattttat tttattttta aaaaactttt acgtttgggg gtacctgtaa aagtctgtta  21781 cataggtaaa ctcctgtcat gaggatttgt tgtacagatt ctttcctgct cctccccctc  21841 ctcccaccct ccatcctcaa gaagatccca gtgtctgttg tttccttctt tgtgttcgta  21901 agttctcatc atgtagctcc cacgtataag tgagaacatg cagtatttgg ttttctgtcc  21961 ctgtgttagt ttgctaagga tgatagcctc caactccatc tatcttcctg caaaagacat  22021 gatctcattc atttttattg ctgcatagta ttccatggtg tatatgtacc acattttctt  22081 tatccagtct gtcattgatg ggcatttagg ttgattctgt gtcttcagaa ttgtgaatag  22141 tgctgcaacg aacattcgtg tgcttgtgtc tttatagtag aatgatttct attcttctgg  22201 tagtaatggg attgcbgggt caaatggtcg ttctgctttt agctctttgc agaatcacca  22261 tactgctttc cacagtggtt gaactaattt acactcccac taacagtgta taagtgttcc  22321 cttttctctg caaccttgcc agcctctgtt atcttttgac tttttaataa aaaccattct  22381 aattagtgtg atggtatttc attgttgttt tgatttgcat ttctctaatg atcagtgatg  22441 ttgagctttt tttcatgttc gttggctgca ggtacatctt cttttgaaaa gtgtctgctc  22501 atgtcctttg cccacttttt aatggggttg tttttctctt gtaaatttaa gttcctcata  22561 gatgcbgggt attagacctt tgtcagatgt atagcttgca aatattttct cccattctgt  22621 aggttgtctg cttactcttt tgattgtttc ttttaccatg cagaagctcc taagtttaat  22681 tagatcccat ttgtcaattt ttgcttttgt tgcaattgct tttggtgtct ttgtcatgaa  22741 atctttgcca ggtcctatgt ccagaatgat attgcctagg ttgtcttcta gggtttttat  22801 agttttgggt tttacattta aatctttaat ccatcttgag ttgatttttg tgtttggtgt  22861 aaggaagggg tccagtttca atattctgca tatggctagc cagttatccc agcattattt  22921 attgagtaag gagtatctcc tccgttgctt gtttttccca ggtttgttga agatcagatg  22981 gttgtaggtg tgtggcctta ttttggggct ctctatcctg ttcatttggt ctatgtgcct  23041 gtttttgtac cagtaccatt ctgttttggt tactgtagcc ctatagcata tttcaaagtt  23101 gggtaacatg atgcctccag ctttattctt tttgcttaga attaccttgg ccatttgggc  23161 tctttttggt accatatgaa gtttaaaata gttttttttc tagttatgtg aagaatgtcg  23221 ttggtaattt gataggaata acatgtaatg atattgattc ttcctatcca tgagcatggg  23281 atgtttttcc atttgtttgt gtcttctctg atttcttcaa gcagtgtttt gtaactcata  23341 ttgtagagat tattcacctc cttgcttagc tgtattccta ggtattgtat tctttctgta  23401 gtaattgtga atgggattgc ttttctgatt tggccctcag cttggtattg ttggtgtata  23461 ggaatgctag tgattttttg tatcctgaga ctttgctgaa gttatttatc agctgaagga  23521 gcttttgggc tgagactagg gggtttttta gatatagaat catgttctct gcaaacagat  23581 ttagtttgac ttcctctctt cctacttgga tgccctttat ttctttctct tgcctgattt  23641 ccctggccag gacttccagt accatgttga ataggcgtgg tgagagaggg cattcttgtc  23701 ttgtgccagt tttcagggag aatgcttcca ccttttgccc attcagtacg atgtttgtgg  23761 tggtttgtca tatatggcta ttattatttt gaggtgtgtt cctttaatac ctagtttatt  23821 gacagttttt aacatgaagc agtgtttaat tttattaaaa gtcttttctg cctctgttga  23881 gatagtcatg tggcttttgt ctttagttct gtttatgtga tgaatcacat ttgttgattt  23941 ccttatgttg gaccaacctt gcatcccagg gatgaagcct acttgattgt ggtggtttag  24001 ctttttgata tactactgga ttcagtttgc aagtattttg ttgaggattt ttgcattgat  24061 gttcatcacg gatatcggcc tgaagtttct ttttttgttg tgtctctgtc aggttttggt  24121 atcagaatga tgctggcctc ctagaatgag ttggggagga gttcctcctc ctcaattttt  24181 ttggaatagg ttctgtagga atggtaccag ctcttcttta tacatctggt agagtttggc  24241 tgtgaagcca tcaggtcctg ggatttttta gttggtaggg tatttattac tgattcccta  24301 aatagaccga taatgatttt agaagtggag tcggtttttt cctggtccag tcttgggaag  24361 gtgtatgtat ccaggaattt atttagctct tctaggtttt ctagtttgtg tgcatatggg  24421 tgttcatagt agtttctgat ggttgttttt atttccgtgg gatcagtggt aacattctct  24481 tcatcatttc tttttttttt tttttttttt ttttttgaga cggagtctcg ctctgtcgcc  24541 caggctggag tgcagtggcg cgatctcggc tcactgcaag ctccgcctcc cgggttcacg  24601 ccattctcct gcctcagcct cccgagtagc tgggactaca ggcgcccgct accacgtccg  24661 gctaattttt tgtattttta gtagagacgg ggtttcaccg tgttagccag gatggtctcg  24721 atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg  24781 agccaccgcg cccggcccat ttctaattgt gtttatttga atcctctctc ttctcttctt  24841 tattaggcta gctagtggcc tatctatctt attaattttt tcaaaaaacc agctcctgga  24901 tttcttgatc ttttgaatgg tttttcatgt atcaatcctt cagttcagct ctgattttgg  24961 ttatttcttg tcttgtgcta gctttggggt tgacttgttc ttgcttctct aattctttca  25021 gttctgatgt tagtttgtta gtttgagatc taactttttg atgtggacat ttagtgctat  25081 aaatttaact cttaacactg ccttagctgt gtcccagaga gtctggtatg ttgtatcttt  25141 gttctcatta gtttgaaaaa acttcttgat ttctgtctta atttaattat ttatccaaag  25201 tcattcagga acatgttgtt taatttccat gtaattgcat ggttttgagc gattttctta  25261 gtcttgactt ctatttttat tgtaccgtgg tctgagggtg tttgatatga ctttggttct  25321 tttgcatttg ctgaggattg ttttatgtcc aattatgtgg ttgattttag agtatgtgcc  25381 atgtggtgat gagaagaatg tatattctgt tggttttggg tacagagttc tgtagaggtc  25441 tattagatcc atttggtcca atgttgagtt cagatcctga atatctttgc taatttcctg  25501 cctccatgat ctaatactgt cagtaaagca ctgaagtctc ctactactat tgtgtgggag  25561 tctatgtctc tttataggtc tctaagaact tgctttatga atctgggtgc ttctgtgttg  25621 gatgcatata tatttaggat agttagatct tcttgttgaa ttgaaccctt taccattatg  25681 taacgccctt ctttgtcttt ttttttcttt gttggtttga agtcttcttt gtctgaaatt  25741 aggattgcaa cccctgcttt tttctgtttt ctgtttgctt ggtagatttt cctccatccc  25801 tttattttgg acctatgggt gtccttacat attttatctt tatctatcca tccagccatc  25861 cagccatcca ttcatccgta tcatttttaa ccaataagga cttttaaaag cgcaaccaca  25921 acaccattaa cataaccaat aaaatctata acaatgataa aatatcatct aatactcagt  25981 ccatgtccaa ttttccctcg ctatctcaaa atcgtcttct tagaaatggt ctgttcaaat  26041 gagatcacat ggacagagga aggcgaacct cacactgtgg ggactgttgt ggggtggggg  26101 gaggggggag ggatagcatt gggagatata cctaatgcta gatgacaagt tagtgggtgc  26161 agcgcaccag catggcacat gtatatgtat gtaactaacc tgcacaatgt gcacatgtac  26221 cctaaaactt aaagtataat aataaaaaat aaaaataaaa aaataaaaag tgaaaaaaga  26281 aaaaaaaaaa aaaaagaaat ggtctgttca aatcacaaac cagattcaga aacaatagcc  26341 atacattaca ttttattaat atgtctctta aatttctttt aatctattac agtctttgga  26401 atttttatgt cttcgtttat ccttccaatt attaaaaaaa aagtattttt gtattcattg  26461 aatagacaat gcttgcagaa aagtaaaaaa aaaaaaattt agtacaaaaa ggtacatagt  26521 gagcbgttcc ttagtctccc ttcccagaag caatgttacc acttttgtac aaatagtctc  26581 tgcctagaca cacatgccag tccctaaggt ggctgtaaca aggtggttaa gagtgagaac  26641 atgaattcaa attcctatta tgccactcac taagtataaa tcttggtcat ggtacatgcc  26701 tctgtgcctc agtttttaat aatggtacct acctcatagg gctgttgaga gaattaaatc  26761 agataagtgc ttaaataact attaatattt attattattc acattccctt ttggcttttt  26821 tcccaaatag cagagtggtg cacatatgtc ttcatttatt tggcttgttt tttcacctca  26881 catcacattt tgatgaataa ttccatacat gttgttatag atttgcttca ttctttgtaa  26941 tcattgacta atattccatt gtatgaatat gctactgcta aacatgtacg ttatttccaa  27001 cctcttatta tcaagaaatg ctgcaatgaa tatccttgta atactttagt ggattcatgt  27061 gcaaaaatat tcataggata aaatcctgaa agttaaattg ctgagctaaa gggtatgtgc  27121 attttaatgc tttatagatt gcccagctgc ctcaaaggag gttataacaa tttacactcc  27181 caagaaaaat gcacaagggt ccccatttcc ccatacccta gctaacacag gatattgcta  27241 aatgctttca tctttgtaaa catgatgtat tgaaaatggt atctcaaagt tttaatgtgc  27301 atttttctga ttgtgagaag ataaaggaaa tgtagtacaa ctaaacatca gcagtcaaat  27361 gacctggcca tgactcctga gtgaggacac tggtaaacac catcaggatc caaacacctc  27421 tgtatttacg aagaggatgc tccctattgg atagcactaa gcttatttca tgtatgtaca  27481 tatgtagtta gttaattaca tccagcggtg gcaaagggct tgttctgacc caatgaaact  27541 ttctctcctg gcccccttcc agcatgtggt caggagtaga gtgttgtggc catgaggcat  27601 gcatttgtac agatgactac ttactcctcc ttgaaacatt tttttccatt tgcttccctg  27661 ctgtctcact catgggtctg ctcctaattc acaaatcact cttttcccag tcttcttggt  27721 tgggttttct cctcttctgt gcttgtagac atgggggagc cccagggctt ctctcttgaa  27781 ctacagcttc tccctgggtt catctccttg ggatgtctgt tccaatgggt ttaaatacta  27841 gggctaggac tagggagagg tcattgaggc acttagcaca taaagtttaa ggaaacattc  27901 tttatcaggc ccatgcaagt gcaggactgg ccctggaggg tgactaccac cttacctttt  27961 ccaccctagg caccttgttt gccttaccct agccccagtc ctctttaaca ccccagtctt  28021 ctccctggac ctccagaaac ataaatccta tttgacattt ctacttggag gttttaaggt  28081 aactcaaacg taaaatatct aagacagaac tcttgcatca cttcccatcc tggggcccaa  28141 gcctgtctct tctactagtc tatctcagtt aacagcatca ccatttattc agttgctcag  28201 gacaaaaaat ttgaagtaat ccttgactct tctttttttt tttttgagac ggattctcac  28261 tctgttgccc aggctggagt gcagtggtgg gaccttggct cactgcaacc tctgcctcct  28321 gggttcaagc aattctcctg cctcagtctt ctgacctcgt gatccactcg cctcggcctc  28381 ccaaagtgct gggattacag gcgtgagcca ccgcacccgg cctggattct tttttttttt  28441 tttaaacaag tcctatcttc catctccaaa atgtatccca aatctgacaa cctctcccac  28501 cgtaggccag cccccatctc tcccctctga aaatagcctc ccttagatct ctggacattt  28561 gttcttcccc acccccttgt gatcactatt cagcattcag aatgatcttt taatattatg  28621 aaggagactg tgttcctctc ctacttaaaa ttctctagtg gcttcctaat aaatttagaa  28681 taaaaagcca actcctcgcc atggtcacca ggccaggatc cagtgggtac aacaatctgt  28741 tcccagcaca ataatcccac ttctgcctcc ccaccattca ccaggctcca ctgcactggc  28801 tcattcctgc ctcagttgtg cttcttttcc ctggaaagtt ctttctgtag atctttaaag  28861 ggtgatttcc ttctcaacat tcaggtgtca gctcgtttca ctttcctgac catgcccatc  28921 cactcagaga tcactcaaaa tcccattacc ctattttatt tctccatcat atgtatcact  28981 atctgaaact atcttgttgt tgatgcaggc tattttcttg accccttcat gggactccca  29041 acaggggtac cccatttact cagcctgccc tgctcaacct cttgcaggag ggagcacacg  29101 agtgaacgag tgcaggaacc agctggctgc tttagtgctg tgaggagtaa actccatgca  29161 ggccctgcag cagcaaccag gtaggggtgc ctgcaacccc agggccccag agggtgtgtt  29221 acaatgctct cgtagctctg ccatctgtgg acagcagtgt gttgtcagct cagtgggccc  29281 tttgcttcat catgtagggt ggctgccctc tgcctgtgag ggcaaagggc cagggtgaca  29341 gtctttttgg gtacccacaa tttgtgcatc ctgaattctt gtttggtgcc caagaagaat  29401 ggggtcacac agatgaactg aaggatggtg aatgcagaga attagcaatg aaagtggctc  29461 tcagcagaga gagaagctga aaagggaatg ggaagggcag gtcactctcc cctgaagtca  29521 agtcacatct ctccaatgtc cagccaccat ctctgaagtc aagtttcctc tctctgatgt  29581 ccagccactt ctcctctcta ctggctgagt ctggggtatt tataggcaga ggataggtgg  29641 tggggcaggc catacataat tttggaaaag gcaacattct attggtaaaa agacattatt  29701 cataaagaac caattgggaa agagcgggca cacagggatg gaagttctca ctttgggctg  29761 caggtttcag gcttttcagc tcaaaagtga ggtttttcca gggacctgcc ccgtctgcct  29821 aaaatttcta cacttctgtc attgataccg ctggataaca gctctcctat aaagttcagg  29881 ggcttaaaac aaaaatttac taattcaccc ggacagttct tgatagggtc tctcctaact  29941 gttgcagtta catagcaact gggttggagt catcttttct gggcttgaca tccaggacag  30001 cttcttccct tgtgtgtctg gtgcctcagt gctcctccag gcagcctttc tctccagaag  30061 agtagcctgg acttcttggc aactcaagct tccaaaagaa aaaaaagcag agactgctgg  30121 ttctcttatc aaacaggcct ggaactggca caatgtactt ctgctgccat attcaggagg  30181 tcaaagcaat cgaaggccaa tccaagttca aaggcattgg agaaaaatga gaagtgtcac  30241 ttaaatgaga agtgacacat gcgtaaaagg gggaaaagca ttgattgtgg ccatttttgg  30301 agataagcta tcacgtttat ttgtttgttt gctttctaat ggtctgtctt ctcccattag  30361 gttataagct ctgtgagaca acaggaatct tgtccatctt gttttatggc tctacttcca  30421 acacctagaa taatgcctgg cacatagtag gtgctcagtg aataacttaa gcacttgata  30481 catgtttggg gaactaaaat gaacagaatt aaacttcccc agattggtcc tgccagattt  30541 gctgatgcca agcatgctga tgcctcacca gatgaaagaa gccctaaaat gtagggtttc  30601 gctttctctg caaacaagaa aaacttgccc tgaacacaaa atctagaaat agatttggcg  30661 tgttttctac attgaaatat ttcccgtagt accagaaatt attttcccac agctttgtgc  30721 tacattaaaa tattgaagtt gactgaaaat atctccattc tttaatcttg gtgtagacta  30781 gaaacaattt ttttgtaaca aagtaaatat gaaaacttcc taatatttga actccccaga  30841 tatccccaga tatctccaaa cttaaaatat cattgcaagt taagataaat ttttttaaat  30901 gactaccgag aaaggtcatt aaaggcttgg ttattaaaat gtacagattt gggttataaa  30961 gccagaactt atttgtttaa atcattacat atgaccaagc acagaaaata aattacctca  31021 aatctcctct ttgctaattt ttactggtaa actctataaa atgatcctat ctttaaacct  31081 ttttgtaaac cccttataag ttagtaagtg agaatgtatt catcagaagg attttagtga  31141 tgtttgaaat taaaaaagag agatttgatt tttaaaatta tacttgcaga ctactgctaa  31201 tgaaacttct tctaacccta gttttgtctt atcttcagtt tttccagatt tgctcaaagc  31261 aatcccagtg agcatccacg tcaatgtcat tctcttctct gccatcctta ttgtgttaac  31321 catggtgggg acagccttct tcatgtacaa tgcttttgga aaaccttttg aaactctgca  31381 tggtccccta gggctgtacc ttttgagctt catttcaggt aagtacaaaa ttctacctct  31441 gaagacaaat gtgcttttca atatgtcaaa aagaccgtct acctaaatat aaagttataa  31501 tcttaacata tatacatgga tgcacactgt agtattatac ataataacaa aaagtgtgga  31561 aataccacac ttgctcaaca gtagggaatt caataaatac tttatggaca tctatatgaa  31621 taactgtgat gctgacatta aattatattt ttgaagatgt aatcaagagg ataaacgctt  31681 gtctcaaaaa gttacatggg aaaagcagta tgtaaactta tataaacatt gtgaacctaa  31741 tttgattata tatataaaat atagggaata tacatataaa atacatatat gtatatatgg  31801 gggctatata tatatatata tgaaagagat agatagatag atagatagat agatagatag  31861 acagacagac agacaataca gactccaatc tgttggtcgt ggttgtctct gacccatgac  31921 actatggggg acttttattt ttgctcatac ttttcaatat ttcttagtgt tcaataatgt  31981 gctattattt atacataata ataaaaataa ataaatggca tcaaaaaaga gtaaagggcc  32041 agtgttccgc ccacatatga gcagccatat tcaagcctgt agacactttg tgtagcctaa  32101 tgctaggtgt atctgggcaa ggataaactc taaagccaga aattagttca tcaataaaca  32161 tgtgctactc aatagctagg gctgatggaa aagaatataa aacccagtct gtgccaaatg  32221 gtgcttacta tctgcaagtg ggagaaggag aaagacgaga aaatgaaaaa tgtgtgtata  32281 atttatatgt agcbgttctg taggagatct ctgacttcac cccattctaa ctttgcaaaa  32341 agatccaaca ctttgtcaga ttcctgggag gcaagtaatt ttattgatgg tttcatggag  32401 ggatacagaa cgataacaac tcacacaaag caaacaatgt aatgaaaatc tctattcgac  32461 tgtttctttt tctcctgaag ttgccctttg gctgccagct accaggcacc aggctcaagg  32521 tactttcttg ctcttgacac tactcccttc tctcatacaa ttcaacccca accacaaacg  32581 tgtatagatc tctctctcta taaaacaaag gcctgtagtt aacaggaggt cacttgcagt  32641 gtagcctctg ttcattgtta cttgtgcaca ctgcttaggg tctcacccca tccacattct  32701 gctaatcaca ttattcaccc atccaatgta gatctctcca gtggagattc tgctaatatt  32761 ttctttagat ttgtcacaag tatataatac agttttaaat tgtacagatg attatcctat  32821 aacagaagag tctaagcctt ttacatcttt gtatctctaa cgaaagcatt cagcatgaag  32881 ctctgtacac agcagacaat tcaatatgaa tttgctgact tgaaacagca agcctagaaa  32941 ggagatgtta acttggtcac ttagacagaa caggtttcag caatcagaat tcagatgaca  33001 tggaactggt agaacaggcg ctttgaagca ataggacatg agccagtgag gagagggatg  33061 gaatatcata aacaaaggcc aagggctttg caatcagagc tgaagagcca agagcacagg  33121 ctcagggtgt gggcagactg aatgagaaag tgattcaatc acatgtgaaa gtccagatga  33181 gaagagagag ttgggattac ttctgctcac caaacatcca aaaccaaaca ggtggatccg  33241 ggtggtgtgc tgttttactg atgaccatta cacagaattt taacagaagg aatgtaaagc  33301 agtggttctc aaactggagt tcccagatga gcagcgtctg catcatctgg aaacctgata  33361 aagcagcaaa ttctcaggcc ctaccccaga cccactgaat cagaaacttg ggggtctggg  33421 ggaagatggc catctgtatt ttaacaatct cccttcagga gattctgagg ctggctcaag  33481 tttgaactac aggtagttgg ttcaacaggt gttggtggac tgacaaacaa aaagagactc  33541 cgaggtaact ccaagatggt aatgtcagaa agcagctacc acccctaggg cttgggggaa  33601 ccaacaaaag agtttggcat tgccagaacc tagaatcttg aggagaggcc ccagagcatt  33661 gtgtctcaga ccttgaggac ttggcactgg gacaccatga ggggtttctg ggtgtgggaa  33721 agggctggaa actccccagt tgctgccacc agggagaact acaagtgaag tggaaggtgt  33781 gggcctttct cccttttctt ttctcgtctt ctctctcccc ctggtgctca tgtttgacag  33841 aaaacagctg aaaaggcaga actagtttgg ggagtcttga cctggcatca taaagcagag  33901 aaaagcaaag ctggagtgaa ggtgagacac aacagctcat tagcagcaac agccgtctag  33961 cgctccagct tctgaatgaa attctgaaga acagcgcact tggaagacaa attatttgac  34021 agttctgaca gacgaccaaa ctaacagcat ttgaaaagca agatgactca gagaatacag  34081 aatttaatcc aaatcccaga tcctatctct gcctttggcc aggcctaatg caaggagaac  34141 ctgagcacac aaatatatgc aggaatgatc aggacctgtg cctgcattct attctgtctc  34201 acccaccttc aaatttgttg taaaaacatg ggctcaataa aggtttgtga atcagggaag  34261 gaagagaagg ggagaaagga agggaaggag ccagctccag atctgtgtct tgcagaggat  34321 aaaggccagt gtttttagat cacccagtgt ttttctaagc ccccaatact tattttgaaa  34381 tatcaaaatg ttcaataact aaaaaaaaaa ccgttacaac aataaaacat gtttgagggt  34441 cagatggact ggcagtttgt gacctctggg gataaacagg tcactttgga atcacagact  34501 tcctcattcc ccttaaatct catatggtac ccagaagccc ttggaacttt ggaaggtgtt  34561 tattcacagt tgtaatgtcc atgcagaccc tggctctaag acccaattgt gtaagggtag  34621 gtttgtagcc cttatcccaa acattctaag tgtgagccaa tgcgtcacac actcagaggc  34681 cagagactgt attggggtcc tttatttcac gtacgagtca cattccatta agagacccca  34741 gaagtcagct ctcttccact gactggttct cttcccttgt ttctcttgcc aatgtgtgct  34801 gcccaggtgg cagtgctcac tgtcagcaga gaagaaaaat gctttcctcc ttggacctct  34861 tttctctttt tctcctccct actcacattc aggttcccta agcttccccg ctccttgtgc  34921 tgaagtcatt ctatggtcat ttcttcaact gtctacttcc ctgctggatg ggcacccaag  34981 acttggcatc ctggggcatg tagaaagggg aaagggaagg gaagggaaaa gaagtcctcc  35041 caattgtcta tctggacctt tccacactgc ccagagtact gctatgggca tctccttatg  35101 tctcccgatg tggtgcatgc cagaccctgc aggtagaaaa ggaaagaaag caacccattg  35161 gaccaggcca gcaaaggctt cagtcacaca gctggctcat acttatggct tcatattctg  35221 ttgcctcttg aaccagacat ttcttccact ctcataacct ccagtttagc tcgtattcct  35281 cagcattctc catgtaatat tgttgcatga aacccatgca agtcagccaa tttgctcttt  35341 ctcatcttgt catttataaa ttgatgctga gaagtctttt tcccaaggtt tttagtaata  35401 ccttcatcat cccccatagt tcattttggg cagtgattcg cttctttgac tgtacattag  35461 aatcatctga agaactttct aaaactactg atctcaggtc tcacacaaca ctaattaaat  35521 tatagtctct ggtggggtag ggcttgggca ctgctatttt accttaagct ctctggagtc  35581 attctaattt gtagccagtg ctaagggttg caatataagt gaatatattt cacgtatttg  35641 tcaaacattg actgagtgcc cattatgtgc cagccattat aataggcact ggtgatccca  35701 cagtgaatca ggcacacaat gctgtcttca cggagcttgt tgtctagtgg gagagtcaaa  35761 caaaagtgta tatcaataat taagtgatta cagattgcaa taattacaat aagggtgata  35821 aacaggttgc tataatatac aatagtattg cctttcacca gacatttctt aaagaggtaa  35881 atcatctatc agacaccttt taaaaatctc atctaatttc aaaagtgtac ataaataatt  35941 aagtgattac agtttgcaat aattacaatg agggtgataa acaagttgct atgaaagaga  36001 aagatagcag agatctggct ttgagatggt ggtcagggaa gactgctcca atagctgagt  36061 tctaaagcta agaaggaact gagaaccttc acagaacgtc ccaagtagaa gagaaagcac  36121 actgaagact ctagggaaag aggtctgctt gttgtaggaa ccgaaagaag gccaatgtgg  36181 ctaggtgctg ggtagtgagg ggaaatggca caaggaaaaa atgaggttag agagatcagt  36241 tgataccagt taatgttgga ccctaaacat taaccatggt aagtctttta gaattgattc  36301 taattgcaat gaaaaccttt tgaaagattt taaaaagata tctgatagct gatttacctc  36361 tctaagaaat gtctggtgaa agacaatacc atcacattgg agatggaaaa agatgaatgg  36421 attctaaaaa cattctgaaa gtacattcaa aatgtttttc aggtagctta tgcaactaat  36481 aaatagtggt ggcattctgg gtaagacaag ggaggagcag gcttgcagtt tagggcaaga  36541 aaggggtggg gagaagagct cagcactaaa atcatgtgtt ccatttgggg cacatcgagt  36601 ctgagttgct atgagaccac caagtggaga tgccaagtaa atagtcagtt acatgaatct  36661 ggagttcagt gaagaggtct agaagaaaga tgtatatttg ggcattattc ggatatagat  36721 attatgtaaa gcaataaaat tggatgagat cacctaggga gagaatgcac atagataaaa  36781 actgacctag gaccacttca tgtctaaaac accaaaagca atgtcaacaa aagccaaaat  36841 tgacaaatgg gatctaatta aactaaagag cttctgcaca gcaaaagaat cagagtgaac  36901 aggcaaccca caaaatggaa gaaaattttc acaacctact catctgacaa agggctaata  36961 tccagaatct acagtgaact caaacaaatt tacaagaaaa aaacaaacaa ccccatcaaa  37021 aagtgggtga aggacatgaa cagacacttc tcaaaagaag acatttatgc agccaaaaaa  37081 cacatgaaaa aatgctcacc atcactggcc atcagagaaa tgcaaatcaa aaccacaatg  37141 agataccatc tcacaccagt tcaaatggca atcattaaaa agtcaggaaa caacaggtgc  37201 tggagaggat ctggagaaat aggaacactt ttacactgtt ggtgggacta taaactagtt  37261 caaccattgg ggaagtcatt gtggcgattc ctcagggatc tagaactaga aataccattt  37321 gacccagcca tcccattact gggtatatac ccaaaggact ataaatcatg ctgctataaa  37381 gacacatgca catgtatgtt tattgcggca ctattcacaa tagcaaagac ttggaaccaa  37441 cctaaatgtc caacaatgat agactggatt aagaaaatgt ggcacatata caccatggaa  37501 tactatgcag ccataaaaaa tgatgagttc atgtcctttg tagggacatg gatgaagctg  37561 gaaaccatca tcctcagcaa actatcgcaa ggacaaaaaa ccaaacaccg catgttctca  37621 cccataggtg ggaattgaac gatgagaaca catggacacg ggaaggggaa catcacacac  37681 tggggactgt tgtggggtgg gaagaggggg gagggatagc attaggagat atacctaatg  37741 ctaaatgacg agttattggg tgcagcacac cagcatggca catgtataca tatgtaccta  37801 acctgcacat tgagcacacg taccctaaaa cttaaagtat aataataata aaataaaata  37861 aaataaaaaa acaaaaattg atgtaggacc aattcctgaa gaacactgac agttaatttt  37921 ttggtttagg aggaggagaa gccagcaaac gacactgagt agcaatatcc aaagaaaaag  37981 aggaaaaagg aaaactggga gattatgagt gtcccagagg gaatgtttca agattaccat  38041 cagcagtgag ctttgtgtaa aggtggcctc ctgtaataga ggtgcgggca ggagaaggca  38101 gaatagggaa aagggggtga aaaagcttcc ctcaagattt ataatacagt ggaagagaga  38161 gacagagaga gagaaagaga aagagagaga gagaacttaa ggaggtagag gaagagagag  38221 aaccaaaaaa gagggagctg agtatagaag caattagatt catagttttt agttgcggca  38281 gtgatatttg agtgggggcc ttttatatat tccattctag gtgtttccca gttgatggga  38341 gagggtctta cctagatctg catgtaaaag ggagtaggcc agctggcaga cttgacatgg  38401 atcagtggta gaacatccta gcagttctgt gaatactctc tgagaatgac atgaaaggta  38461 ttggttcagg ccttttggag gtgataaaaa ccaccaaaat gtggacttat tgcaaattgt  38521 atttgttacc atttgcaatg attataatta ttctcttata tataggcttt cttacatata  38581 gcttctctta cacatagcgt catgagttat gccttctctt acatatagtg tctgctatga  38641 gttatgccaa gcagggcaaa caaaattgct gcctttcttt aaaaagagga cgctcctagt  38701 atgggcctaa ttaattatga taattacagc tatggcatgg aacataagca cattcatata  38761 cacaaagaca ataaaataaa gaacagttca aaaacagaac agttacatta tatatcagtt  38821 tcagtatgaa taataccctg gactctgaaa tatgtctggg gcacattatt ctgtaattgg  38881 tggtgaaaaa aaatctgcat cttatctcta cgccaatcct tatgaaggag ctgtttttca  38941 ggagttcgag aaagagacac agggatgtcc agtcatcaaa gccgcagagc ctgaggaaga  39001 ataaaggatt tgtggcagga aaacccagta atgaatgtat tctgctagtt tctcagcata  39061 gaacttagaa aagaggccac agaaggaaaa gagaagtaat gttagacagc tgatgttggc  39121 aatgggcaaa gaatttcatt ctcatatgca gggcagtggc taaaggggca gtgttgtgag  39181 gaatcacatt ccaggtcatt catgtccagg gtgtggtagg aggactgtgt ttcatttatt  39241 ttgtacatgg cccagctatg accttgtgca aggaaatgct taatcatttt ctatcacagt  39301 tgcaaagaga ttcttatcct actcagaatg tacgtcttct cttctgtttc atttacagtc  39361 acaacccaag tccttgcttt gacctccaaa gcaccacttg atgtatccac ttcagaaaca  39421 cacacagaca gctcacctct ttctatccct taccttcctc ccctcttcac tcaaaccacc  39481 tacttccttt gcattcactc ttccttcagc ctgaaataat cttcctccaa atatctacct  39541 tctcactccc tcacttctct caagatacac ttaaatgtta tattccctat gaggcctccc  39601 ctggccatcc ctccccagcc ttcctatccc ccctctctgc tttattttat tctccttaat  39661 atatatcaca ctctgataaa ccattgaatg tacttatcaa gttattgcct ctctctccct  39721 ttccattgtc tccatcactg agagctctgt gaagaaaagg atttgtacct gtttcattta  39781 gtgctgtacc cccagttccc acaacagcgc aacaggcact caataaatag ttgttgaata  39841 agtgaataaa acagaagtag ctgcatattt tctggtaaca aatgatattc ttctgaaaat  39901 gtcatatttt cagacatatt tccgaaaata aattcaaatt agataaacat tgtattttta  39961 gaccatttct tctttgcatt aatcatcctt ctcaataata taacatttgt aaaacttagg  40021 ttagatatgg gctcttcaac tttccattac agaagataaa gtgaaaaggc tagacccaat  40081 ggtgttattc cttcatctac atctatcctt tggaaacaca tgaccaaatt gcttgccatc  40141 acaatctcaa aatctaccct ttggtattaa ctcacttcac ttgtccctct gtcccttttt  40201 agatggtagc catcggtctc tggagcagtg tagagtcaga acaacttcta tttggggaag  40261 aaatcattgc tggtgacctt actttcaatt actaactttc tagtgacatt tacataattt  40321 tagagaaaat taacacctac acttgtaaag ttgtggcttt cccacaccta tttatcatct  40381 ctcaatattc cttgaaaagg aaattatcaa tttatcattc tatattggca atgaaatgcc  40441 cctaatatct gtcacctata agacaattga agatgatgtg ttgaaagctt tctgaaaatg  40501 ctgatcatta ctttaaatgg aattgaaatt ccagtttatt atttccaaaa atatgatctt  40561 actgatcata ggataacatt tcataacatt tcagagattt cttccccttc gaggagccaa  40621 acccatagga cctctggact cccacagatc ctggcaggga gttcccactc ataaaagcac  40681 aggtgccctc agagtcattc agggatgaag aagcaaccct cattggccat gtcctacgtt  40741 ccccatatag taaggactgg aggagaccag tgctcaattc tgcagtctca gacagctgtc  40801 agaggagagt catgaatgtg cagtgtctag cacattacaa acgtttgtta attgactgat  40861 cattcatggt gtgacagccc tataactcag ctatcctatt cagtcagaaa ttaactcagt  40921 aatcaaagtc attaaaagga agaaaaaaaa aacctacagt accagacaga tggtggggaa  40981 atcagacaga tgaaaggaaa aatggctgta ggtcattgag taagacactg ggcagcaaaa  41041 cctgggcctt gtgcctggtt atactccaca ttatagctcc agcaaggttt ggcaggattt  41101 ccacagtcct ggcttattct aacctttctt gggagcagga gcagtgttgg tcagatagac  41161 agacacataa ggaatctgtc caactggcac cgtgtgaatt tgggctcttg gtgtacatgg  41221 ataactggga aaaagaggag agagacatgt aggactgatc ctaccgtttg tgaagtcttg  41281 ggcaagagta tgaatgaaaa cccacttctc ttcccctgcc tggctccact gcacacagta  41341 aagagcctca agcataggtg tgtggacatt gcaccatgta tccaagctct gaccatgcct  41401 cttgaaacag ctattcctca gccaccctct gaccatggga ggaatgaccc aggagaaatg  41461 accacatagg tcttgaaaat gggctcaggg ctatttacga agtcaattcc ggggtcccag  41521 gagtatggac taaaatgtga gtcaggcatg ccagatgggt atgttctatt gacttcaagg  41581 attcctcatg ctgtgggaag gaacctctcc agaagagaga cagagcagaa ccctctaaat  41641 gtggggcaca aagcaggagc ccctcttgct ggattcaaag ggtcatactg gaagagtgta  41701 ggttgagtct tattctcaca tcactcatat cacttacaca cttcttttat agccttagca  41761 gccatgccac aaagagaaac tcttcatgca tatcttttgg tccataagtc ataaatagtt  41821 atccttgatc ccatgtcttt tttagagcca tggacagaga gaagcaaaaa tataccaagt  41881 tcacactgag ttgtctccct tcatatctct tagcagtcac tgaaaggtta tgagactcag  41941 gcbgggtttc tatcctctgt ccctgaaacg acaacgttga cctcgtgatc aaccctagaa  42001 tccagagcaa gatctcagac tgtcctctct actaccagac agcacacttt gttttggggg  42061 ctgtgtgctt gaaatattag ctatggcaaa aggctttgag tcttatgaca ccccaagtaa  42121 cttttacttt aggaatttga aatacagcct tgctgtaatg ctgtctcctt aacaaagcag  42181 tacctttgaa atatttaaca acttgaaaag gaaaccgagc ttgaattttc ctttcaggtg  42241 ctcaggaaat aatgtttcac ttctgtctga aattcaccat ctcctcagac aaagaaggct  42301 cttatggtaa aaggaatggc attttctcca caattttcga ataaaagata aagagaaaac  42361 agcactgcag cctttttgtt aggatctaac aataaagaaa taatacggtt ttgccagggg  42421 agagctctgg ttttaagctc agaatacaaa aataggctga caaaatttta caaaggaata  42481 ttctcagcta ccactctgag gatggtagaa agtgaaattt caagaaaatt atattatttg  42541 attatttgat gatgattaag ctgattggcc agtcctatgt gaaattctaa agtagaagaa  42601 atgtgatgtt gtcttttctg ctcacctctc ccctcattcc tacccccaaa tctctgcctc  42661 taccccaaac ccagcctgac ctttgggaaa ggaatggggg ctgtcacttg caccgtagct  42721 cctcctgcct gcagtactct ccccccacag tccagcctcc ctctgctcag ctaacttttc  42781 ctatagctcc ttctggctac ttctaaggaa ccttccataa tgctgcccac cctctcagta  42841 acagcccctc tactatccct tgattacatg cactgtaatt ggttagtaat tgattttatg  42901 tcctctgcca aattatactc catgagagca aaaatcatga gtattatctt taatgtttaa  42961 atctccacaa ctatccccca tataagtcta gagaataaat gaatgagtga attaatgaat  43021 agaaactcaa gccattatgt tgccactcct aggatatttg gattaacttt aactgaagag  43081 taaaaagcat ttacctgtcc taaaggagac ataaaattag tgggagagta tttggagaaa  43141 aaaaagacac tgtaatacat tcttttgtgt tgcctaccct gatgtagtca ggtgtccctg  43201 atatggggtg ggctgaggat ttgaaataaa atacctaatt tgacattgta agtggaggaa  43261 tcaggatttg aaaccaaatt ggtttgacct aaatcaagct attatgataa ggacttgcaa  43321 gaaaaaagga atccataaaa accatatgaa tagctaccaa ttagtaagca tttatatgtg  43381 tcaattacaa agccaaatgc aaatcatgct ttatttatat tagccacctt ttatagatga  43441 agaaattgag acctgaatat taaaattgcc tacttttaca tagtaagtaa aggaatcagg  43501 gtttgaaccc aaattggttt cacctaaggt agaaaaccat cccagcaagt ctcctattaa  43561 ctggaaccct attgtggtgg cctgagatat aacagtagct gtggaagcgc tgtagagtcc  43621 tggccatcct atgtgctcct gatctggtcc ctcctgccac ctgcttctgc tccctgtgcc  43681 atccacccat ctggaagtct cccagtgtcc atcttcgggg gagacactca ccagagtttc  43741 cagcttccag ccagtatgga gtgcccctgt cccacagcaa tctcaccgaa atcacagcta  43801 catctgttaa aattaggcta ccaatgagtg atagatgagg gggaaaaata ataatagtgt  43861 actaaacaaa acaaatgttt atttttctca cacataaaaa tctagaggtt gaagtccagg  43921 gctggtccag aggctccaag gatctgggat ttagactccc tctttcttgt ttttccacag  43981 catatggctt ccatttctgg ggccacattg gtccaaaatg tatgcbgggg ctccagccat  44041 tgcatccata tttcagccac aggaaggagg aagtggggaa gaaaggacag gcccctaata  44101 cctgtatagt tcaagaagac tatcccgccc atacttccca accaccctta gttgaacaat  44161 gcbgtcttaa ttcaagacac tcacatgtct agccaaaaat ctgaattctg ttacaaacaa  44221 ggagaataga gatgtgcgcc acctcaatac ctcatccata gctacctttt cctttgtgca  44281 gctgtggcca agtgaaagct gaaggagctg tggtaaccct tctgaaggga ggctggggcc  44341 tttcacaaga ggctgcatga ttgacattta tcctgcatgg cctgtgaagt acagagaaat  44401 attttctctt gaagccacat catagcagtg gctgctttgt agcctgattc caccattatg  44461 cctttaaagt gcctagcaat tcagccttca catcatgcaa agaggaatat ctcccagtct  44521 ttgtaagatc agcttaattc taaccacctc cttacctccc actgcactcc tacacgcaca  44581 cacaaatctt cttcactcag agcagaacca taacccaagc cctaccacct agagactgaa  44641 gaatcaggct catgattaca aatatgcaat aattttttgt gtggataatg tcaatgggga  44701 tgatggtaag agaattcctt ggtttacaca ttgaccctct tccctgtccc ttacaatcag  44761 gaaatatttg tcccaacacc ttgtttcttc tgttgcaggc tcctgtggct gtcttgtcat  44821 gatattgttt gcctctgaag tgaaaatcca tcacctctca gaaaaaattg caaattataa  44881 agaagggact tatgtctaca aaacgcaaag tgaaaaatat accacctcat tctgggtcat  44941 tttcttttgc ttttttgttc attttctgaa tgggctccta atacgacttg ctggatttca  45001 gttccctttt gcaaaatcta aagacgcaga aacaactaat gtagctgcag atctaatgta  45061 ctgaaaggca aacctttcta taattttaca agggagtaga cttgctttgg tcacttttag  45121 atgtggttaa ttttgcatat ccttttagtc tgcatatatt aaagcatcag gacccttcgt  45181 gacaatgttt acaaattacg tactaaggat acaggctgga aagtaaggga agcagaagga  45241 aggctttgaa aagttgtttt atctggtggg aaattgcttg acccaggtag tcaaaggcag  45301 ttgactagaa tcgacaaatt gttactccat atatatatat gtgtgtgtgt gtgtgtgtgt  45361 gtgtgtgtaa gatgtcttcc tatcaaaaag atatcaaagg cacatggaat atattttaat  45421 aaaaacaaat aatatctcta atatatccac acatttgttg ccagatttca gaaaactgag  45481 ctgcaatcgc tttcctaaaa cagtagtgta ttaaatgaac atctataaaa tgtatcaaca  45541 cacattttaa aaaatttgtt taaagtatac tcttaggcca ggcgtggtga ctcacacctg  45601 taattccagc acttcaggag gccaaggtgg gaagatcatt tgagttcagg agttcgagtt  45661 acagcctggg caataaagtg agaccctgtc actaacaaaa ttaaaaaata aaataaatat  45721 aaaatatagg ctttaaaaaa gcatagtctt attaaccatg tctgttggtc aaaatctgca  45781 aactctaaaa gaagaaaaga agaaaaaacc aagcttaggg tatttttcct cccgtgcctg  45841 agtcccaatt acattcacga cagtactttc aatgaacata attgttagga ccactgagga  45901 atcatgaaaa atgatctctg cttagtacat ttgatgcaaa atgacttatt aggggctgtt  45961 tttctagcta tagtgtctcg agtactaata tgcaattatg aaaattatat taaatctggg  46021 attatgacgg tatcactgta tcatcttggt cttgttctgg ctgtcaccaa gcatgaccca  46081 ggtcaacttt ttttttcccc tgaattaccc atcaaattga tctgcagctg actaaaggcc  46141 acagctgagc ctggaactga cccttccttc atcctcaacc tgctgtcctc cagaaagcac  46201 caaggaaaaa gcagagaatg acagcaaaca gatcactagg cctctgacca caggtgctga  46261 gtactcagca gccctcatat aataggtttg aaagtactcc ttaaaataaa acactgtttc  46321 cctttggaac tatttacaag gatgaaacaa ccgtatacct gagaaataac ttgctctggt  46381 gtcaattcgc tattcgccag cagacatcag aacacaccga gtttccagat gctggttttt  46441 ccccttaaat caggaaatac acctggacaa tttctagaag actacaattc agtctagcca  46501 caaaggggat tttttttttt tggtaacagg ctagagcccg gttctgtaag tctttagctg  46561 aaatggtcca gtacaaaagc actggaaatg agtgggctag gaggacaagg accgtctcct  46621 gcgtgaggag ttggttggag gtccccaagg ccaggtaccc cctgcactct tattggattc  46681 ctctctgtct tcttggagtt ttgaaaaact ccttcgaaca ccaggctttt ttctttagaa  46741 aacaagtctc caatcgttct ctgttccgta gaaagagaaa gaaaacctgg agcagctgct  46801 gaaaaatcta atgaggaact aagaggcaaa cccacca 

[0166] A non-limiting example of a human wildtype CLRN1 genomic DNA sequence is SEQ ID NO: 47. The exons in SEQ ID NO: 47 are: nucleotide positions 1-544 (exon 1), nucleotide positions 28764-29180 (exon 2), nucleotide positions 31239-31418 (exon 3), nucleotide positions 32481-32519 (exon 4), nucleotide positions 44799-46433 (exon 5), nucleotide positions 44799-44935 (exon 6), and nucleotide positions 46128-46837 (exon 7). The introns are located between each pair of these exons in SEQ ID NO: 47, i.e., at nucleotide positions 545-28763 (intron 1), nucleotide positions 29181-31238 (intron 2), nucleotide positions 31419-32480 (intron 3), nucleotide positions 32520-44798 (intron 4), and nucleotide positions 44936-46127 (intron 7).

Transmembrane Channel-Like 1 (TMC1)

[0167] The TMC1 gene encodes “transmembrane channel-like 1” (TMC1). TMC1 is a calcium-dependent chloride channel and interacts with transmembrane O-methyltransferase homolog in the stereocilia of hair cells. Mutations in TMC1 may lead to non-syndromic sensorineural hearing loss. For example, a D572N mutation in TMC1 has been associated with deafness (Kurima et al., Nat Genet 30:277-284, 2002, and Wei et al., J Transl Med 12:311, 2014).

[0168] The human TMC1 gene is located on chromosome 9q21. It contains 24 exons encompassing ˜314 kilobases (kb) (NCBI Accession No. NG008213.1). The full-length wildtype TMC1 protein expressed from the human TMC1 gene is 760 amino acids in length.

[0169] An exemplary human wildtype TMC1 protein is or includes the sequence of SEQ ID NO: 48. Non-limiting examples of nucleic acid encoding a wildtype TMC1 protein are or include SEQ ID NO: 49.

[0170] In some embodiments of any of the compositions described herein, the TMC1 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 48.

TABLE-US-00015 Human TMC1 Protein (NCBI Accession No. NP_619636.2)  (SEQ ID NO: 48) MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKER  RRRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRW  FAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLP  EYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMC  IGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVE  ENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDL  FAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSEN  STGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSY  TEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGM  LLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMV  LAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAAAAGRQ  Human TMC1 cDNA (SEQ ID NO: 49)  atgtcacccaaaaaagtacaaatcaaagtggaggaaaaagaagacgagactgaggaaagctcaagtgaaga  ggaagaggaggtggaagataagctacctcgaagagagagcttgagaccaaagaggaaacggaccagagatg  ttatcaatgaggatgacccagaacctgaaccagaggatgaagaaacaaggaaggcaagagaaaaagagagg  aggaggaggctaaagagaggagcagaagaagaagaaattgatgaagaggaattggaaagattgaaggcaga  gttagatgagaaaagacaaataattgctactgtcaaatgcaaaccatggaagatggagaagaaaattgaag  ttctcaaggaggcaaaaaaatttgtgagtgaaaatgaaggggctcttgggaaaggaaaaggaaaacggtgg  tttgcatttaagatgatgatggccaagaaatgggcaaaattcctccgtgattttgagaacttcaaagctgc  gtgtgtcccatgggaaaataaaatcaaggctattgaaagtcagtttggctcctcagtggcctcatacttcc  tcttcttgagatggatgtatggagtcaatatggttctctttatcctgacatttagcctcatcatgttgcca  gagtacctctggggtttgccatatggcagtttacctaggaaaaccgttcccagagccgaagaggcatcggc  agcaaactttggtgtgttgtacgacttcaatggtttggcacaatattccgttctcttttatggctattatg  acaataaacgaacaattggatggatgaatttcaggttgccgctctcctattttctagtggggattatgtgc  attggatacagctttctggttgtcctcaaagcaatgaccaaaaacattggtgatgatggaggtggagatga  caacactttcaatttcagctggaaggtctttaccagctgggactacctgatcggcaatcctgaaacagcag  acaacaaatttaattctatcacaatgaactttaaggaagctatcacagaagaaaaagcagcccaagtagaa  gaaaacgtccacttgatcagattcctgaggtttctggctaacttcttcgtgtttctaacacttggagggag  tggatacctcatcttttgggctgtgaagcgatcccaggaatttgcacagcaagatcctgacacccttgggt  ggtgggaaaaaaatgaaatgaacatggttatgtccctcctagggatgttctgtccaacattgtttgactta  tttgctgaattagaagactaccatcctctcatcgctttgaaatggctactgggacgcatttttgctcttct  tttaggcaatttatacgtatttattcttgcattaatggatgagattaacaacaagattgaagaggagaagc  tagtaaaggccaatattaccctttgggaagccaatatgatcaaggcctacaatgcatcattctctgaaaat  agcactggaccacccttttttgttcaccctgcagatgtacctcgaggaccttgctgggaaacaatggtggg  acaggagtttgtgaggctgacagtctctgatgttctgaccacctacgtcacaatcctcattggggactttc  taagggcatgttttgtgaggttttgcaattattgctggtgctgggacttggagtatggatatccttcatac  accgaattcgacatcagtggcaacgtcctcgctctgatcttcaaccaaggcatgatctggatgggctcctt  ctttgctcccagcctcccaggcatcaatatccttcgactccatacatccatgtacttccagtgctgggccg  ttatgtgctgcaatgttcctgaggccagggtcttcaaagcttccagatcaaataacttctacctgggcatg  ctactgctcatcctcttcctgtccacaatgcctgtcttgtacatgatcgtgtccctcccaccatcttttga  ttgtggtccattcagtggcaaaaatagaatgtttgaagtcattggagagaccctggagcacgatttcccaa  gctggatggcgaagatcttgagacagctttcaaaccctgggctggtcattgctgtcattttggtgatggtt  ttggccatctattatctcaatgctactgccaagggccagaaggcagcgaatctggatctcaaaaagaagat  gaaaatgcaagctttggagaacaaaatgcgaaacaagaaaatggcagctgcacgagcagctgcagctgctg  gtcgccagtaa 

[0171] A non-limiting example of a human wildtype TMC1 genomic DNA sequence is SEQ ID NO: 50. The exons in SEQ ID NO: 50 are: nucleotide positions 1-113 (exon 1); nucleotide positions 56102-56223 (exon 2), nucleotide positions 94568-94677 (exon 3), nucleotide positions 106121-106263 (exon 4), nucleotide positions 126797-126864 (exon 5), nucleotide positions 166909-166956 (exon 6), nucleotide positions 172743-172914 (exon 7), nucleotide positions 178718-178843 (exon 8), nucleotide positions 218319-218409 (exon 9), nucleotide positions 220644-220725 (exon 10), nucleotide positions 230050-230156 (exon 11), nucleotide positions 232986-233084 (exon 12), nucleotide positions 250613-250755 (exon 13), nucleotide positions 266539-266683 (exon 14), nucleotide positions 267323-267517 (exon 15), nucleotide positions 270086-270265 (exon 16), nucleotide positions 270391-270552 (exon 17), nucleotide positions 283582-283710 (exon 18), nucleotide positions 294343-294410 (exon 19), nucleotide positions 299042-299281 (exon 20), nucleotide positions 305069-305194 (exon 21), nucleotide positions 308651-308729 (exon 22), nucleotide positions 308831-30882 (exon 23), and nucleotide positions 314151-314551 (exon 24). The introns in SEQ ID NO: 50 are: nucleotide positions 114-56101 (intron 1); nucleotide positions 56224-94567 (intron 2), nucleotide positions 94678-106120 (intron 3), nucleotide positions 106264-126796 (intron 4), nucleotide positions 126865-166908 (intron 5), nucleotide positions 166957-172742 (intron 6), nucleotide positions 172915-178717 (intron 7), nucleotide positions 178844-218318 (intron 8), nucleotide positions 218410-220643 (intron 9), nucleotide positions 220726-230049 (intron 10), nucleotide positions 230157-232985 (intron 11), nucleotide positions 233085-250612 (intron 12), nucleotide positions 250756-266538 (intron 13), nucleotide positions 266684-267322 (intron 14), nucleotide positions 267518-270085 (intron 15), nucleotide positions 270266-270390 (intron 16), nucleotide positions 270553-283581 (intron 17), nucleotide positions 283711-294342 (intron 18), nucleotide positions 294411-299041 (intron 19), nucleotide positions 299282-305068 (intron 20), nucleotide positions 305195-308650 (intron 21), nucleotide positions 308730-308830 (intron 22), and nucleotide positions 30883-314150 (intron 23).

TABLE-US-00016 Human TMC1 Gene Sequence (NCBI Reference Sequence: NG_008213.1)  (SEQ ID NO: 50) 1 cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt  61 tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc caggtaagga  121 aagacaacat tattacctat gtgtggtgtg ttaacattct ttatgaaaca tgtgtgaaga  181 cctaaatcga agactttctc catgagatat tccctaatca cattagtgaa ataaaactat  241 atttcctcta cttttctact gctacagaaa tctcccccag ttaggatagt cccagtttcc  301 tatttatctt tgtttttctt gcagtgcaca gcatgtcacc cagtaattga taagtttttt  361 tttttttgag acggagtctt gctctgtctc ccaggctgga gtgcagtggc gcgatctcgg  421 ctccccaagt agcbgggact acaggcgccc gccatcacgc ccggctaatt ttttgtattt  481 ttagtagaga cggggtttcg ccgtgttagc caggatggtc tcgatttcct gacctcgtga  541 tccgcccgcc tcagcctccc aaagtgctgg gattacaggc gtgagccacc gcacctggcc  601 taattgatat gtttaaatgt taaaattaaa tgcaatgatt tcctaaaata aacaaatgtg  661 ggacaattta ttgcactctg ttcaaattcc cattttgaag tggaattcaa acaaacatga  721 cagtaaaggg ggacagtgag cacagggaca agagaaaagg agaaagggaa gaaatacaga  781 gaactagata ggaggaagtg tcaaagactg atgggtgtaa gccaccttta cctctggata  841 ttggttttcc tttgaattgt ggtatgtggt catattgctt attagttata acatacagct  901 gtcagaagag tttttcaatt aaaatttcaa atgtaatatt aaaactgttt ggattccttc  961 ctactgggca ctggacactg tctgtggagc tgctggaaca gcgctgaata gggtcatatt  1021 ttaaaggaac tcagcctagt gcagtttctc aaccttagca ctattggcct ttggggcctg  1081 ataatccttt tttgtgaggg gctgtcctgt gcactgtagg atgtttagca gcatccttgg  1141 cttctactca gtagatgaca gtatcaaccc ccttccccag aagtgacaat taaaaatgtc  1201 tccagacttt tccaaatgtc ccctgaggag caaaattgtc tccagttgaa aaccactggg  1261 ttagtgggag aaacagataa gacagaagtt ctccatacac catgataatg ccatgatgcc  1321 atagggctgg caggagtgaa gggaagagca tctcacaaag actcgggggg atgcagggag  1381 gaggaaaaat taggaaatga agtgggctga gttgcagtta gcctgtgggg aaaatgaagg  1441 agaagggata aggaagaaga ggaggaagga gggaggaaga gtgaggagta atagggaatt  1501 atagttgacc ttgaacaact tggggtttag ggatgccgac ccttgcgtag tcaaaaatct  1561 gagcttaact tttgactacc ctcacacttt cctaacagcc tactgttgac cagatgcttt  1621 accaataaca taaacagttt attaacacat attttgtatg ttttatgtat tatacactgt  1681 attcttacaa taaggtaagc tagagaaaag aaaatgctat taagaaaatt gtaaggaaga  1741 aaaaatatat ttactgttca ttaaggggaa gtagatcatc ataaagctct tcatccttgt  1801 catcttcaag ttgaataggc tgaaggagga gggggagaga gaagagactg gccttgctgt  1861 cttaggggtg gcagggatgg tagaggtgca ggaggtggaa ggggaggcag gaaaggcagg  1921 cacactcggg gtagctttcg ttgaaagaaa tcttcatatg agtggaccca tgcagttcaa  1981 acctgacttg ttcagagtca actgtacttg ttccaggcta agaacagaga ataaaaaaaa  2041 aatgtataga ggcctgaaac agcatattat attaaaagaa ctcaaagccg gtaaatgctt  2101 tgctactgaa gcataaagtg agaaaggggc atcatgggct ctgaaattgc agccacaagt  2161 ctacagaaca catttttcat agcccaaggt cagtcttcta ttaccctttg cagtgaggtt  2221 atcatcatcc attttcactc gtcagtgctg gggagcccat taaatacttg ccactatact  2281 tggtcccaac agttaataga ctgtagcatc ttttatttct tcacctagcc tgaaatcagt  2341 tgagcttttg cagaatctta gatatgtcgt ttttttcttc aggtttagaa tggggcactt  2401 aaaaagatgc atagtacttg aaaatagaga aagaaaatag catgtagaaa tttgtgcctt  2461 tattctgccc aaacgtctca aaaaggaaaa aaataatttt aagggtaaat attgtcatca  2521 atttatctga gctcttttga cttcctttga gcctgaaaaa caggatcagt gtctttttag  2581 tatttaccat agtgcctgat atgtagaagg tgtttgacca atgtttatta gataaatgtt  2641 cacttttatt actagtaata ttaaccacat tttaatagag actaataata catgataaac  2701 ttctcaagga tgcgatctca tttgatcact ataacaaccc aatgaggtaa gcgaggaata  2761 gttgttaact ctaatacatg ttatatctta tccttgaccc agtattaccc cagtcatgcc  2821 ttcctttccc tgcaatgaaa gaaaaccgat aaacacaaaa tgttgtatcc catataagca  2881 ttcattctta tggtagataa gtaaatggaa aagataggta tgcattctca atttttttaa  2941 gtcctagaat tataaaacag taaagaagtg agaagagaga gaaatcttaa gggaccaacc  3001 tcttgatttt acaggtgaga aaactgaggc cacatagcca tttagtgcag agccaggatt  3061 ataaaccaga tgtttggaat cctatgtggt ggtggacacg aggatatact aattagcgtc  3121 gttaccggaa aattccacat atctctaagg agcagatcac cacacacctg cacagcccaa  3181 gcctggattg tggaggtttt tcttgtagag tttgtctttg atagaaagat acggtccaga  3241 aggccggctt caaggacata agaaagggca tattcaaaac aaatacatgt atgcctattc  3301 ttttaaaccg gtacttaaca atagtatcca ggtgtccaaa tataatagct tatctgtttt  3361 attttttcca gaaaaggaaa caaggtctta gagaggttac attttgcata ggattttgtt  3421 agccaagtca gcatctgttt gcatcttaaa aatgagtcat acctattcct tgtaagtagg  3481 acaggagggc agctggaatt tcccagctca ctccttgtca ctgcttcctg cctctgctgc  3541 tctttgtcct ccacagcacg cttcattggc taaaaagtga accagatact acattacctc  3601 agggcagttg taagtactga gtcagatgcc ttaggcttgt gtgatgggaa gtttagggcg  3661 agaccaatgt cttgctttaa caacagtgtg aataagttaa tttcttttga gattttatta  3721 ctcaatattc cacccagaaa gaaacacaga tgacactcag ccaatcaaag gccatctggg  3781 actgacaaac gcagagcttg ttgtagatga caaggctcag tggatggatc atcactgaaa  3841 gaaagggaaa cagtttgaac tgttgtatct ctctccttgc tcacatgaaa aacaaaaaaa  3901 tccttggcca gttgcggtgg ctcacgcctg taatcccagc actttgggag gcccaggcgg  3961 gcagatcact tgaggtcaga agttctggac cagcctggcc aacatggcaa aaccccgtct  4021 ctactaaaaa tacaaaaatt agccgggcgt ggtggcacac acctgtattc ccagctactt  4081 gggaggctga ggcatgagaa ttgcttgaac ctgggaggtg gaggttgcag tgagccaagg  4141 tcgtgccact gcactccagc ctggatgaca gagtgagact ccgtctcaaa aaaaaaaaaa  4201 aattccttaa ccacagacta agtaagcatt attgcacaga gtgtcattcg ctaatcttgc  4261 ttgtgcctga actttgaaag caccagcccc ttgctttggg ggcbgggggc gtggggtgta  4321 agtgtgtgtg tcctctagaa gaagacaaca ctgagaacag aaggagagga tcttggagat  4381 ttgttaattt cctattgcag ttagccttgt ctggggctct cactttagca cttaaaataa  4441 catactcctt tgcacagatg ttattttttt ctcttcatgt gtacaacttg aattatccaa  4501 tggccttgct ttgaggatat tcatcctatc ttattgatcc tgtcactgtg taggacaatg  4561 gagaacacag taaaaaaccc tcaatggata ctacttacac taaattaact ctatgaattc  4621 aaaatttgaa gatgctactt aatcatgtaa gcctggttct ccaaaacttc atctgccatg  4681 ggaaaaatca aagcttgtaa aatgattaaa cttgtaaagg aattaaactc taggattcac  4741 tcattttata attggtattt tcaccctaag agctttcttt ttcctctctg gtgtttaaaa  4801 acaaagtaaa accagacaaa acaagattaa ctaaattaaa acccctgtga ctttaaaaaa  4861 tgtagccaag aataatgtgc aagtgtctag ttaggccaat agatatcctt aacatacgtg  4921 agcbgggaac acaaatgagc atgaagggca aggaagagca ccaccccctg cttcttttcc  4981 tgctcctgtt cttgcagagg gtcaggcttg gagaccacat atggtcagct caacactcaa  5041 gtccaccaag cagcccatga ggaactcttc cttccagagt tgtgcacacc atgcagtgtg  5101 gtccacctgc agaagcacac aacaggcgct gcctgggcca gaggtccatt caggccatgg  5161 aattggtctc aatgccattt aggcatgaat ccagggtcct gggtaccaga cgcatggtct  5221 aggtaggggg tgtcatgtac taggtgagca tggggttccg ctgggcatgt tcccttgtct  5281 tgtaggatgt tagctctgag gggcgtggct ggaagaaggc tagccttgag ccctctaaaa  5341 ggcagggctc agggcaaagc tcccagttgc tcaggcctgt gggtaatact gcttaaaaat  5401 ccccttgaga acttctttaa aatgcaaata tctcgattct tttgtagttc aaaagcatga  5461 tgattgggtg ttcacaggca tgtgtaagac gtgacaccct ctgaacctcc ttatgacccg  5521 gtacattacc tgtctgacct gaaaaaaaaa tgcaaatttc tggattctac ccgcctcccc  5581 gcactccgac attacgatgt agcagctctg tggtaggatc caggaatctg cctgtgtaat  5641 cacaggttga tattctggtg tttcctggtt ttgctctgct gatttggggg atgtttacca  5701 gcaggagagc agcctctttc ctctgccctc ctcccttgct gccctcccca gaccccagtg  5761 actcacgctc ctcctgctcc tcctgttgct ggcctctctg ttgtggttgc cagcgctact  5821 ttgcagacgc tgcctgctcc ctgcacgcca acacagattc tgtttccctg cgaccgctgc  5881 tgctgttgtt tgttccgtcc ctggtttatt gtaggagagc tgattgttct gttgccactg  5941 ctaccaagct gcaaacacca ggctcacggt gcaaggggaa ggggcttctc ctctgggtgt  6001 tctgcctcta tcgcctaggc tctcaggctt tgttgccaat ggcactgcga gaccctaaac  6061 tatggccttg tgattcccac atctccattt agttctttct tttgttctct aagatctgag  6121 aaggagccca tgtctttcag tgttcctgtt ttcttgcgat acttcccccc tccccgactc  6181 cagaatttag ggcaaccttc tgcbgtggtc tgaatgttta tttctctcca ccccgccaaa  6241 cttatatgtt gaaatcttaa cccctaaggt ggtggtatta gaaactgaag cctctgggag  6301 gtaattaagt tataaggaca aagccctcat gaatgggatt actgttctta taaaaaaaag  6361 gccccagaga gctagctagc tccttccacc atgtgaggac acaacgtgaa ggtgctgtct  6421 atgaggaagg gtccctcacc agacaccaat catctggcac attgatcttg aacttcctat  6481 cctccagaac tgtaaacaaa taaatttctc ttgcttataa accataagtt catgattttt  6541 tttttttttt tgagacggag tttcgctctt gttgcccagg ctggagtgca atggtgtgat  6601 ctcggctcac aacaaactcc gcctcccggg ttcaagcgat tctcctgcct cagcttccca  6661 agtagcbggg attataggca tgcgccacca tgcctggcga attttgtatt tttggtagag  6721 acagggtttc tccatgttgg tcaggctggt ctcgaactcc tgacctcagg tgatccaccc  6781 gcctcggcct cccaaagtgc tagggttaca gatgtgagcc actgcacctg gccaagttca  6841 tgatttttgt aattagcatc caaaatggac taaaaccccc atcctcctga aggttctgaa  6901 tctgaggacc caagacttgg ctctcagcct taatgtcctg ctcccactat tttcaggggg  6961 cccaatataa atttcctgag tttttgaggt ggttgggctt gcagactgac ctttagtatg  7021 ccctttgtta catttacaaa atagattgct tacagggtta gacaaataca gttgaccctc  7081 tgtatccctg ccttccatat ccatgggtca aaattatttg gaaaaaaaaa tgtgtctgta  7141 ttgaacatgt atagattttt tttttgtata tttcctaaac tatatcgtat aataactact  7201 tacagagcat tcatattgta ttaggcatta taagtagtgt agttatgatt taaagtatgt  7261 gagagaatgt gcacaggtta tacagaaata ctacaccatt tttttttttt taatcaggga  7321 ctgaagcatc ttttcagcta tgactttggt atccggtggc gggtggggcg gtgggtgggt  7381 cctggaacca ttcctccatg aataccaagg gataactcta attgctaaat cgtttcctat  7441 ttttgtgaac tggtaaagga ctgcatgaga aaggccaaaa attaaagaat aatatgctta  7501 ttcaagcccg gtgtggtggc gggcacttgt agtcctagct acttggaagg ccgagatggg  7561 cccaggagtt tgaggctata gagggctatg gttgcacctg tgaatagtca ctgcacacta  7621 gctcgggcaa catagctaga ccctgtctct aaaaaagaaa aattctgctg taataaacct  7681 gcacgcataa aatgatgtct atgtgtctat atagtgtgta tatacatatg tgtttaggaa  7741 atgtgtatat atgtgtgtgt gtttgtgtgt gtggatactg tattagttaa gacaaaaaaa  7801 tctggcttca tatgttataa aataatgtct ggagctatcc actcaagtgt gctttcttgt  7861 ttctctgttt tttttttttt cctatttcat tcagtggttt tcactgcctt tgggaaaaag  7921 tgacacagca aaacacttag aagaatcaaa tgtttatcct ttgagaatgt ggtctgtaca  7981 taagagaaaa catttagaat caaattatga gactaaacca gtttccctca cctgcagcta  8041 gataaaaatt tctaagagga aggagagaat caggaaagat tgaagacttg actccctgat  8101 aagggttctg cccgagttct gagaatggag aataaaagac accctccccc tctctaatag  8161 attttgtcag tgaaggtcag agaggcccac gaaatcaggt ctggggagca aggtaaaacc  8221 cagaatttct acatgatcat gttaaagagg gaataaagga atatcattat agtgtatctg  8281 ggcaggtggg catgagacag cctgattgag ttcctgaaat cccaggtcgg tgtgggagca  8341 gcagaatatt ttaggtggct gagagctcca tagtttcttt ctttctttct ttctttgaga  8401 tggagtctca ctctgttgcc caggctggag tgtagtgacg cgatctctac tcactgcaac  8461 ctgtctccct ggttcaagta attatgtctc agcttcctga gtagcbggga ttacagatgt  8521 gtgccaccac acctggctaa ttttttttta tttttagtag agatgggatt ttatcatgtt  8581 gcccaggctg gtctcaaact cctgacctca agtgatccac ctgcctcagc ctcacaaagt  8641 gcbgggatta caggtgtgag ccaccagcag tcccagctac tcaggaggct gaggcagaag  8701 aatcgcttga acccgggagg tggaggttgc agtggaccga gattgtgcca ctgcactcca  8761 gcctggtgac agagcaagac tccatcttaa aaaaaaaaaa accttctcaa ggtattttct  8821 gtgcttcttg ttttctcttt tgtatttttc atctttatat ctttgtgttt cattctggat  8881 aacttttagt gacctgtctc ctagttcact aattctcttt ttagctatgt ctagtattat  8941 aatttgttta ttgaattatt aagtttaggt atcaaatttt cagctttagg atatctaatt  9001 tgccacttgt tttctgccat gatttttttt ttttttttga ggtggagtct tactctgtca  9061 cccaggctgg agtgcactgg tgtgatcttg actcactgca agatctgcat cccgagttca  9121 catcattctc ctgcctcagc ctctcaagta gcbgggacta caggcgcctg ccaccacgcc  9181 cagctaatta ttattattat tattattatt tgtattttta gtagagacag ggtttcacca  9241 tgttagccag gatggtctcc atctcctgac cccatgatcc acccaccttg gccttccaaa  9301 gtgctgggat tactggcatg agccactgca cctggcttct gccataattt ttaaccttga  9361 gttttaccta cttaaacata gcaaacacag ttgtttatat atttatctaa taattccagt  9421 atcaggagcc tctggagtct acttttgtct actttcattg ttttttgttt tttaaattta  9481 cattaacagt gtctagtctg tatttatgcc tggttacttt tgattgtgtg ctagacattg  9541 tttttggcaa ataatttttt aaacacaata tgtacaaatc atatgaagcc tagactggtg  9601 ttttgttcac caaaaaagat tttaaattac ttcagttacg ttcctaggga cactattaac  9661 tcaggatgat gttaattgaa gtttcagatt tgatattttc caggtcaact ggaccaactg  9721 tccctgctat atgatttatt tcctaaagca atatcaagtt cagctctgca cctctcttat  9781 atactatgga gctctcagtc acataaaata ttctgctgct ctcacactgc cctgtagttc  9841 ataagaggaa cagtttactg ttaatccgta ttactcttac atctagggtg tagctctttg  9901 agctaccagt ccaaagtgaa gaataattta ctgaattcct actttgtctg gctctaggca  9961 ctgatttttt ttaccctctt ggccacctat cttcaattgg aaaatgccct caattcaaaa  10021 atgctccaag tgccaagctt tcctatctga attcccattt tttcctgtat ctggctggca  10081 attcattaga atcctgctag ccctctgatg cttctaagat tttcatcttt tatttttatt  10141 tatttattcg agatggagtc ttgctctgct gcccaggctg gagtgcagtg gtgtgatctt  10201 ggctcactgc aacctccatc tcctagggtt aagtgattct cctgcctcag cctcccaagc  10261 agcbgggact acaggcatcc accagcatgc ccggctaatt ttgtattttt agtagagatg  10321 gagtttcacc atgttggcca ggctgatctt gaactcctaa cctcaggtta tctgcctgcc  10381 ttggccttcc aaagtgttgg gtttataggc attagccacc atacccagcc tgaagttttg  10441 attaaaaatg ctttactggg ctgggcatgg cagctcacgc ctgtaatccc agcactttgg  10501 gaggttgagg cgggcagatc acttgaggtc aggagttcga gaccagcctg accaacatgg  10561 tgaaacccca tctctactaa aaatacaaaa attagccagg tatggtggtg catgcctgca  10621 atcccagcta ctcaggaggc tgaggcagga gaatcgcttg aatctgggag gcagaggttg  10681 cagtgagccg agatcgtgcc actgtactcc agcctggaca acaagagcga gactccgtct  10741 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaactt taccggaatt  10801 aaagcccagt catcttgaag ccatgatcat gacgcbgtgg aagaaccggt gaggtaggat  10861 gagacatatt ctcagatgct atgctgattt ggggcbgtga tgattttgga ccatagacta  10921 tgatgaggct tcaaaaagag tgcaatagtg tattttaatt tctttggtta gattcaaatt  10981 aatcttcaga aagacaaaat gcagatgtag tcttgttaga gcttgctgat gagactaaat  11041 tttccaagtg tttgaggaat gcctaacagg ggaaaggcaa agcaaactat ttttaatgac  11101 cttatggctc tgaattgcta aaagggagtc agtccaccag gctcaggcta cttggagtag  11161 aggatcctgt ttcagtgaca aactggctca tcccttaatc tgccataaaa tgatggctta  11221 gcatacatgt aggagcbggg gctaagggag aaggaggtgc tgtgttttgc agaagaagct  11281 acattctgta gtaaggcctg actcttccct ggccttggag gggaaatact tgtgagacag  11341 tggccaggat cagctgaagt gccctctctt cttgctttgc ctatgggaca ctgagcccct  11401 ttttgtggaa tatattcatc cagagaaccc tcacacctta taatgcataa agtgataaag  11461 gcttggagat ctggagaaac ccaaggtgcg atccctggct ctagaagaaa ctctgggcag  11521 ccagcatgat ttacttttct ctgctccaaa gactggagga taaattaaag gaaaagaggg  11581 tatgacccag caatccactg gtgcgagttg ttgctttaag caaagactac tgcttctctt  11641 cctgattttc ccctgaccat actctcccag aggtgtctcc cagcaaccac cagagttgtg  11701 gttaagtaca cctagccaat ccaataaatc taaaggagat gcagtccaca caaccttgca  11761 tgacttgtca tgtgagttac tgttctggag agacaaactc aggctggaaa cttatttgag  11821 atagcttatg aaaacaaaga taatttatga taaggataca ggcactctca tacaatctaa  11881 ggtagaaaaa cagctaagca tcagaacaaa ctggaccaaa gacttaaaca cttctgctcc  11941 tttgtgtaat tggtttcatg cgtttctctc tctcccttcc tctctctctt ttctctctgt  12001 ggactaggtt tttctacttt tcatatacaa attttaaaaa tacaatttct ggccaggtgc  12061 agtgactcac gcttgtaatc ccagcacttt gggaggccga gggaggtgga tcacttgagg  12121 ccaggacttt aagaccagcc tggccatcat ggtgaaactc catctctatt gcaaatacaa  12181 aaattagccg ggtgtgatgg tgcacgcctg taatctcagc tacttgggag gctgaggcag  12241 gagaatcgct taaacctggg aggcagaggt tgcagtgagc tgagattgtg tcactgcact  12301 ccagcctggg taacagagtg agaatctgtc tcgaaataaa tgaataaata agtaaaataa  12361 acaataaaaa taaataaaga caattttaaa aatttcccaa cattaagtgt cagcaatttg  12421 gagagggaca gctgtctctt gttctctctc ttctccaatt ctcaattcct aggtctgatg  12481 ctttccctgg ctcaactgac tatggttgtg gggtagggcc atgaaacaga aatatcacat  12541 taggatccaa cctttaatta tgtagatgga cagcagttta cagaaaaagt ggtggggagg  12601 tggagggagg tgctgaacag acattctaaa agggctccac caaagaaagc tatttgttat  12661 atttatgaac attctggaaa attctttcaa ttgtgttcat gaataaatta tgattggtta  12721 aaagctaaca cacatgtaga ttatataact tctaaaattt gtatttggta tctgaatcta  12781 tatattattt tggcatgtat agaaaaatcc cagatatttc aaaggctatc attagaaaaa  12841 cgttaatgaa aaggttaatg gaattctata tatttagttc ctgtgagaat gtccagttta  12901 actttcttaa tcaactgatg aagaaacaga actgaaatca caagattata aagatatttt  12961 aacgatgcat ttaggttttc attctaaatg ctgaaaaaag gtatccctgc aaatactggt  13021 taagaaatta agaagtccaa aacccaataa tgtagttggc agcctgttat aaagatttag  13081 agtattcaaa gataaaggca aataaaaaga ctacttttta taccagagta gaaacagttt  13141 attttcatga tcactactct tacttcaaat atatctatta tctaagttga tgcttgcaaa  13201 aagtcctgat tcttacacaa aggcagtcga ttcatggatc tcttagagag agagaaaaaa  13261 aaaaagctag ttgggtgtgt tacagttata tgaatcatgt aggatgctgc ttaacgctat  13321 atttatcatg gatgaaggca tgttttcagg ggaaactatg agtctaccta aagttaccca  13381 gttcacctct gttccaaggg actcatcttt tcagcatttt gtttagcatg ttacaaagta  13441 ccccgatgtc ttctaaacta ttaggattgc aggaggaaac tctcccagag ctgctagaag  13501 tcatccttga aagtttggat ttctcccgaa aacttgtatt tctatcattg ttttaactat  13561 cttcttgaat cctcttgatc ctgacctaca tgtcctcttc ccttgattgc atttaaattt  13621 agctgcatat aaccttgctc ttttccttct aatccaacct ataaaccata tcaggggagg  13681 atatgtgatt tgtcaatttt gttgcctcac ttcctcctca agaactttca gtggctccat  13741 tttacctctg agattaaatt gcagccactc atcctgagtt ttggtgttcc acaatctgac  13801 atatctagtc agctttgtgt tctagtgtgt ttgtgttgct ataaaggaag actgagacta  13861 gatagtttaa taagaaaaga ggttgatttg gctcacaatt ctgcttgctg gaagattggg  13921 catttggtaa aagccttagg ctgcttctat tcatggcaga agagtaagcg gagccttcat  13981 gtgtggaaat catagggcaa gggaggcagc aagggaggtg tggagaggtg ccaggctctt  14041 tttaacaacc acttctcatg ggaactaata cagtgagaac tcactgactc tttctacagg  14101 gagggcatta atttattcgt gaatgattct cccccatgac caaaatacct ctcattaggc  14161 cccacctcca acattgggat aaaatttcaa catgaggttt gaagggggga caaacatcca  14221 aactatagca ttctgctttg gccccctaaa acttatgtcc ttctcacatt caaatacaat  14281 catttcttcc taatagtccc taaaagtctt aacttgttcc agcataaact caaaagtcca  14341 aagtccaaag tatcacctgc gactcaaggc aacttcttta cagctgtgag cttgcaaaaa  14401 taaaaaatga attatattct tccatgatac aatggttgta caggcattga gtaaacattc  14461 ccatttccct aagggagaaa ctggccaaaa gaaagtggta acaggtccca tccaagtctg  14521 aaacccagtg cggcagacat tctttttttt gaggcagagt ctcgctccgt cacccaggct  14581 ggagtgcagt ggtgcgatct cggctcactg caagctctgc ctcctgggat cacgccattc  14641 tcctgcctca gcctcctgag tagcbgggac tacaggcagc tgccaccatg cctggctaat  14701 tttttgtatt tttagtagag acggggtttc actgtgttag ccaggatggt cttgatctcc  14761 tgacctcgtg atccgcctgc ctcagcctcc caaagtgctg ggattacaga cgtgagccac  14821 cgcgcctggc cagacattaa ttcttaaaac tccaaaataa tttcctttga ttccatatac  14881 cacatcctgg gcatagtagt gtgaggggtg ggtcctaagg ccttaggcag ccccactctt  14941 tggctttgct gggtgcagcc cacgtgactg ctctcacaga ttgaagccca atgcctgtgc  15001 ctttttcagg ctgcagttgt atgttgctgg tggctctata attctggggt ctggagggtg  15061 gtagccctgc tcccacacct ccaatagata atgcccaagt agaggctgtg tgtggttgat  15121 ctgaccctat ggcagacttc tgcctgcctt cccaggtgtt ccaataaatc ctctgaaatc  15181 taggtggaag ctgccaagcc tccaacattc ttgcattatg ggcacctgca gatttcacac  15241 catgaagcca ccaaggctta ccacttacac ccacctaagc agtggctcaa acagtacctg  15301 gggccattgg agccatggat ggagccagag tggccaggat gcagacagca gcatcctgag  15361 gcagcacagg gcagtggtac cccaggcttg tcctgcaaaa ttattttgtc ctcctaggcc  15421 tctaggcttg tgatgggagg agcagcctca aaggtttctg aaatgccttt ggggcctttt  15481 ttttccaaag tcttggctat tagaacctag ctcccactta gtcatgctaa tatctctcta  15541 gcaagtgttt ggctgcatcc ttgaattcct ctcctgaaaa cactctttct tcatctacca  15601 cagggccagg ctgtaaatct tccaaatttt tatgctttac ttggttttta gttacaattt  15661 acaactttag gtcactcatt tgctgccata tctagtttac aatcatattt acaattaaaa  15721 gcagtgtaaa ccaaaaagta tctgagacag gtctcaatca atgtaagggt ttattttgcg  15781 atggttaagg accatggccc atgacacagc ctcaggaagt cctgagaaca tgtgcccaag  15841 gtagttttgt gtagcttggt tttatacatt ttagggagac agaagttaca gacaaaaaca  15901 taaatcaata catgcaaggt atacattggt ttggcccaga aaggcaagac atctacaagt  15961 gggggcttcc aggtcatagg tatattcaaa aatttcctga ttggcaatgg ttgaatgagt  16021 taagctctgc ctgaacagtt gaagtcagct tgagttaaga taaagaggtt ggctgggcac  16081 tgtggctcat gcctgtaatc ctagcacttt taggaggctg aggtggtcag attgccacct  16141 gggcaatctg tttgagatca gcctgggcaa catgatgaga ccctgtcttt ccaaaaaata  16201 aaaaaattag atgggcatgg tggagcacac ctgtagtcct tgctactcga gagactgggg  16261 caggaggatt acttgagccc aggaggcaga ggttgcagtg agctgagatt gcaccattgc  16321 attccagcct gggtgacaga gccagaccct gtctgaaaaa aaaaaaaaaa aaagtgaaag  16381 tcaaggttct tgtcatgtgg atgaagcctc caggtagcag gcttcagagt gaatagatga  16441 tgaatgtctc ttattagaac ttaaaaggtg tcagactctc tggaaaaaac ttggtaaggg  16501 agagattctc tacagaacac taacttcctc cacaagagac aacattgcag ggccttttca  16561 aaatgtcaaa taaatatatt ttgggataaa atacttgtat tgtattgtat tgtattgtat  16621 tgtattgtat tgtattgtat tgtatcgtat ttttgagaca gagccttgct ctgtcatcca  16681 ggctggagtg cagtggcacg atctcggctc actgtaacct ccgtctcccc agctcaagcg  16741 attctcctgc atcagcctcc tatgtagctg ggattacagg tgtccaccac catgcctggc  16801 taattttttt gtatttttag tagagatggg gtttcaccat gttggccagg ctggtcttga  16861 actcttgacc tcaagtgatc tgcctgcctt ggcctcccaa agtgctggga ttactgggat  16921 tacaggcatg agccaccaca cctggacaat aaaatacttt tatttccttt aggtcttgct  16981 atgtcatgtg atgctatatc agagtcgggt tcaaatttgg tatcttattg ctacaaagag  17041 tctgtcttgt cagtcatatg atctctgttt taatgttaat gctggtcatt tgtgtctaaa  17101 ctccaaaggg ggagggtgta ataaggcatg ttgggtaccc tctcatcttg ctatggcatg  17161 agctagtttt tcaggtttct ttgggatctc cttgaccaag gggtccattc agttgattgg  17221 gggagtttga attttaattt tgatttccag cagccacgcc acttcttgaa tgctgtgttg  17281 cttagaaatt tcttctgctg ctgggcatgg tgactcatgc ctgtgagagg caggcacttt  17341 ggaaggctga ggtgggcaga tcaattgggc tcaggagttt gagaccagcc tgggcaacat  17401 ggcaaaaccc catctctaca aaaaatacaa aaaaaaaaca acaacaaaaa aacaaatcag  17461 ccaggtgtgg tggcatgtgc ttgtagtccc agttactcgg gaggctgagg tgggagaatg  17521 acctcagcct aggagatgga ggtttcaatg atcctagatc gtgccactgc attccagcct  17581 gagtgacaga gcaagatcct gtctcaaaaa caaaacaaaa caaaacaaaa tttccgccag  17641 atatcctagg tcatcactct taactgcagc cttccacaaa tccatagggc atggacacaa  17701 cacagccaag tttttttttc taaagcataa catggaaccc tttgctctag ttcccagtaa  17761 gtttctcatt tccttctgag acctgctcag ccttgccttt actatctata tttctatcag  17821 cattttggtc aaaaccactt aactaatctc taagaagttc caaactttcc ctcatctgcc  17881 tgtcttcttc tgagccctcc aggttcttcc aacctctgtc caatgccctg ttccaaagtt  17941 gcttccacat tttcagttgt ctttacagca acatttcact acttggtacc agtattctga  18001 ctttgtccat tttgcattgc tttaaacgaa taccggagga tgggtcattt acaaagaaag  18061 gggtttattt ggctcacagt tctgcaagcc tgtacaagaa gcatggtgcc aggatttgct  18121 tttggtgaag gcaaggaagc ttccattcat ggcagaaagt gaaggggagc ctccatgtgc  18181 agagatcaca tggcgagaga ggaagagcgt gagaggaggg gaaggtacca tggtcttttt  18241 aacagaggta caggcttttg agggaactaa cagattgaga actcgctcac tcccacccct  18301 gccagggagg tcattaatct attcatgagg gatccaccca cataacacac acatctcact  18361 aggccccacc tccaacattg ggatcaaatt tcaacatgaa gtttgggagg gcgaacatcc  18421 aaagtacagc accttgtttc ttgttgtttt ctaatatttg ttctttatcc caggaaatgg  18481 ggggtaggaa ggtgagttct tggtgtactc taagcagtca tgctcagcct gtactatcaa  18541 attttattcc atttattctt ctgttgaggc ttgcatgact tccctaaggt acaatggcag  18601 agatagccac atgggtagta aaatcagggg cagacagacc agctttctgc caggaattta  18661 cctcagggaa attcctcatc tttgactttc ctcgttctga cttttttttc ttttaattcc  18721 acctcctctc caaacctggc actattcctt tccgatcttt atccttgtcc ttactgtttt  18781 gaagttggct cttatgcctg tttgtctttg caatctgtct ctgcgtcgcg tgttggtagt  18841 catttatttt tgtccctagt catgattccc agaaccttgc tgtggtcatt ttgatgcccc  18901 accctttgac tattacaaac caggagagct catgcaagtg gccacatgct gtagtggtta  18961 agagcacagg ccccgtagct gaacttgaaa ctcagcatga caacatgctg gctgtgtgac  19021 taaggcaaat taaatgacca ctctgtgtcc ttattttctt atacataaaa tggagctaca  19081 atagtacctc ctcataggga tgttgtgaag cttcagtgag ttaatacaga tataatgatt  19141 agttatctgc ctccattaaa tccaatcatc aatactaccc agctttatta aaacttctga  19201 cttttgtttt ggatgtggcc aggtcctgaa ctgaattgtt ttttccaggt caaatttaaa  19261 tctaccctcc tttccttttt ctcaatgcca aattgttctt cagtttccat ctctagcccc  19321 ataatctttg atttctcttg cccacatgga tggttacctt ttctgaaatg tcatagctct  19381 tacagtgcta gccacctatt ttgatgccaa atctttacac caaccagtgt tatcacttaa  19441 tcaattctta catctatgtc ttaacttctc caaccaaact taagacttgt tggtgccaag  19501 aatcaaatct catacttttg agttattcaa accatacaga acagtagata ctgaataagt  19561 atttgtctga atgaattgtt tgaataactt aaagagccta gaagcggctg ggtgcgatgg  19621 ctcatgccta taatccgagc actttgggag gctgaggcgg gccgatcacc tgaggtcagg  19681 agttcgagac cagcctgaca aatatgatga aaccccgtct gtactaaaaa tacaaaaatt  19741 agccgggcat ggtggcatgc acctgtaatc ccagctactc aggaggctga gacaggagaa  19801 tctcttgaac ccaggaggtg gaggttgcag tgagccaaga tcacaccatt gcactccagc  19861 ctgggcaata aaagcaaaac tccatctcaa aaaaaaaaaa agagcctaga agctttccag  19921 ggtggtcttg ggggtattgg ctttagaaga ggaagcttga tagatgaaaa tttccagatc  19981 aacggcattt tatgtacttc tcagaaacaa ggtatgacta gactgaaaga tctgaagtca  20041 ggaagaaact tcttggtatc agtctgtgcc cttaggaaga agtgaggtca taagctctat  20101 tagcacacat agctgaaaaa ctgaaagagg atgtaagaga aaggattgtt aaaaaacaaa  20161 aacaaaaaaa cacaaaaaac caaaaataaa aaatctgggt gaggtatttg caatactaga  20221 gccaaagaat ttgacctaag aggccgggcg tggtggttca catctgtaat cccagtactt  20281 tgggaggccg aggtgggtgg atcacttgag gccagaagtt tgaaactaac ctggccaact  20341 tgttgaaacc ccatgtctac taaatacaca caaaaaaggg cccggcgcgg tggctcgtgc  20401 ctgtaattcc agtactttgg gaggctgagg tgggaggatc acctgaggtc aggagatgga  20461 gaccatcctg gctaacatgg tgaaaccccg tctctgctaa aaatacacaa attagccggg  20521 tgtggtggca tgtgcctgaa gtcccagcta cttggagggt gaggcaggag aatcacttca  20581 acctaggagg tggaggttgc agtgagctga ggtagcgcca ctgcactcca gcctgggcga  20641 cagagcaaga ctctgtctca aaataaacaa ttaactgggt gtggtggcac acacctgtaa  20701 tctcagctgc tcctgagcct gaggtgggag aatcacttga acccgggagg cagaggttgc  20761 agtgagctga cattgtgcca ctgcgctcca gcctaggggg gagaaaaaga aaaaaaagaa  20821 ttctgatcca ggcactgact cattgagcaa gtcatcttta ctgttcaggc ctcagctttc  20881 ttcctttgtt tttttttgag acagagtctc attctattgc ccaggctgga gtgcaatggc  20941 atgatttcag ctcactgcaa cctctgccgc ccgggttcaa gcaattcttc tgcctcagcc  21001 tcccgagtag gtgggattac aggtgcctgc caccgcgccc agctaatttt tgtactttta  21061 gtagagatgg gggtttcact atcttggcca ggcbggtctc gaactcctga cctcatgatc  21121 cacccacctt ggcctcccaa agtgctggga ttacagatat gagccaccgc acccagctag  21181 gcctcagttt tctaatgtgt aaaatgaaaa tatgcactag accttcactt gtttttttct  21241 atgtgataat tttttttaaa aaaagaaggt gtcatgttac attttatctt tatgtttaca  21301 tttcatcttg taaggttgcc tttgagcctt gacacagtga tttttctcat tcaactagtt  21361 tctctcccat ctcaactagt gacctcacca tccactaatt gtttaagcca gaaattggga  21421 acttttcctt ggttcctctt ccttgtttac ttcttccatc taccccatga gcaaatccta  21481 tctgttcttc cttaaattta gttcccagat ctatctcctg catctcaggt ctatgtactt  21541 cttcccatct cccctgctac tagtctgtcc agagctacaa ccacttccct tatagattat  21601 tggaataacc ttcttattgg tcttcatatt ttcactctga ctcccctctg atcaattttc  21661 tgcaatgcag ccagaattat cttttaaaaa tgtaagtttg agccaggcac agtggctcac  21721 gcctgtaatc ccagcacttt gggaggccaa ggtgggagga tcacctgagg tcaggagttt  21781 gagatcagcc tggccaacat ggtgaaactc tgtctctact aaaaatacaa aaattagctg  21841 ggcatggtgg tgggtgcctg taatcccagc tacttgggag gctgaggcag aactgcttga  21901 acctgggagg ccatatatat ataaagtttg atcacaccac tgtcctgctt aatctttttt  21961 tattttttaa cttttaaatt ttttaagaga agggtctctc tgtgttgccc agactggtct  22021 ctaattcgtg ggctcaagag atcctctcat cttagcctcc caagtagctg ggaatacagg  22081 catgtgccac cacacccagt gactttcctt cctaaaatgc ttcaatagtt tctttttctt  22141 tttctttctt tctttttttt tttttttttg agatggagtc tcgttctttc acccaggctg  22201 gagtgcagtg gcgtgatctt ggctcactgc aacctctgcc tcccgggtta aagtgattct  22261 tctgcctcag tcttccaagt agcbgggact acagcatgtg ccaccacacc tcaataattt  22321 tttgtatttt tagtagaaat gggtttcacc atgttggtca ggcbggtctc gaacagctga  22381 gcttgtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggtgt gagccactgc  22441 acccagccac ttcaatagtt tctttttgtg cttaacataa agtttaaatt catgtccaga  22501 gcctataagg tgtcatatga ccaggcccct caaggtatat ccacttcact caagccatgt  22561 ttgtctcatc ttaattcttc aaacacccca cattctttcc taactcaagg tctttgagct  22621 tgctgcttct tccaggtgga ctgatcttag cccttccctt tgttgttgat tttttaactt  22681 tttttttttt ttttttgtga gaaagtcttg ctcttgtttt ccaggctgga gtgcagtggt  22741 gcaatctcgg ctcactgcaa cctccacctc ctgggttcaa gtgagtctcc tgactcagcg  22801 tcctgagtaa ctgggattac aggcacctgc caccacaccc ggctaatttt tgtattttta  22861 gtagaaatgg ggttttgccg tgttggccag gctgatcttg aactcctgac ctcaggtgat  22921 cctcccacct cggcctccca aagtgctggg attacaggca tgagccagcg ctcccagcct  22981 ttttaccttt ttttttttta atttcaatag gtttttgggg aacaggtagt ttttggttac  23041 gtgaaaagtt ctttagttgt gatttctgag attttagcac acccatcacc tgagcagcgt  23101 acactctacc caatgtgtag ctttttatcc ttcacccccc caagtctttc cctgagttcc  23161 caaagttcat tgtatcattc ttatgccttt gcattctcgt agcttagctc ccacttacga  23221 gtgagaacat acaatatttg gttttccatt cctgagtctc caattccacc caggttgctg  23281 tgaatgccat taatatgttc ctttttatgg ctgagtagta tttcatgata tatatataca  23341 cacacacaca cacacacaca catatataca cacacacatt tatatgtgta tatatacaca  23401 tatatatata tgtcacattt ctttatccac tcattgattg atgggcattt gtagccctgc  23461 cctttgaatg gctgacttct tcttatgctt cagaattaat actttgtaat tacattaata  23521 tgtttttttt aaaaaaaaac cttttacata tatattggtc tgtcacaata atgtataaca  23581 atattatagt ttctgtttta atgacttaac tttggcaaac tggtcaatga tttcattaaa  23641 actgatcttt ttaaaaataa tcagcttcaa tagacagttt aaccagattt gtcaactttt  23701 tgtttttggc acagtctcac tctgttgccc aggatggagt gcagtggtgc catcttggct  23761 cactgcaacc tctgcctcct gggttcaagt gattctcatg cctcagcctc ccgagtagct  23821 gggattagag gcacctgcca ccatgcccag ctaagttttg aatttttagt agagataggg  23881 tttcaccatg ttcgccaggc tggtctcgaa tgcctgacct caagtgatct ggctccctcg  23941 aactcccaga gtgctgggat tacaggcgtg agccaccaca cccggtctcc ataaaaaaat  24001 cttaaacaaa aggatatggt tggtgaaata caaatcctat tgcgcagtaa ttttcacaaa  24061 ttttaaaatt gacaatacct tcgcttcttt cagatcaatt atagtggctt tcaaatgtca  24121 tcgctcaaaa aagttcaaat gtcatcgctc aaaaaaaaaa caaaccttca ctagaaaatt  24181 aatcataaat tgatggtaca gactgggtgc agtggctcac aactgtaatc ccaccacttt  24241 gggaggccga ggtggatgga tcacctgagg tcaggagttc aagaccagca tggccaacat  24301 ggtgacaccc cagctctact aaaaaaaaaa aaaaatgaaa aaattagccc ggcgtggtgg  24361 tgcatgtctg taatcccagc tacttgagag gctgagacag gagaatcgct tgaatgcaga  24421 aggcggaggt tgcagtgagt cgagatcata acactgtaat ccagcctggg caacagaggg  24481 agactcctca aaaaatataa aaataaataa attgatgtta catttggaaa aactgctgaa  24541 attttcttct tctgcaaaaa gttagaaaaa accactgaat gattgaaaac attgacatta  24601 tttaattctt tgctttagag caagtactca gttcttgatt gaagtgattg agggattcaa  24661 acattgtcct tttgttttct tccggtaacg tcagaccagc atattttgtt attgctgctg  24721 gctgttttct tcaaaatttg ctttgaaaaa gatgtaaatg gccatttcct tatacttgtg  24781 attaaatatt tgttggcctt tccaccagtt ctctgcactg atcttcaaga aaaaatttta  24841 aaacctgcac acaaaatttt aaagactgaa cacagaattt taaagcatgc acatttttca  24901 aagcbgtttc tatctctttg gaagtttgtg tctgattaag ttcatctaag acttcactcc  24961 aggaaaaaag ttaacccaga aaagataaat agcctcagca gagagaaaaa tctactgatt  25021 ttcttgtgtc tacattttgt tttagatagc ataatacttc aaaagttggt actcatttct  25081 taaactttac tgtgtgcata gcttcaaaat gaatactttg ttgtgtgtgg gaaagccttt  25141 tcattgttat acttacaatc ttcagcatgg tccatccgtg aatctttttt aaaattgata  25201 aaaaggccag gcgcgatggc tcatgcccgt aatcccagca ccttgggagg ccaaggcaag  25261 tggatcacct gaggtcagga gtttgagacc agcctggcca acatggtgaa acctcgtctc  25321 tactgaaaat acaaaaatca gcbgggtgcg ttggcgtgcg cctgtaatcc cagctactca  25381 ggaggatgag gcaggagagt ggtttaaacc tgggaggcgg aggttgcagt gagccgagat  25441 tgtgtcactg cactccagcc tgggcaacag agcgagactc cttctcaaaa aaaaaaaaaa  25501 aaatggttaa aaagatgaaa taaaaatttt ccaagttccc ctcaaccccc ctaaaaaaaa  25561 atcatacatg aagaaacatt tccaaaacag tggagtttgg agattgattt gcacaagcac  25621 aaatgaggat ttaggataaa tttctttgac ttttacctga acactacagt cagtcttggc  25681 catagtttca gcattgccat gtccttggtc atgatagagg ttcatgtcca gcatatcaca  25741 attcagtcat atggtgacta ttatgtgagt tcaggagtgt ttatcctaga aatagaaaga  25801 cacccaggaa tgactccttt ctttcaaatt tgctgttctc aaaatgaaca tacttaagga  25861 ctttacattt gatcagggta taaaccactg ggaagactaa gtgctcagaa aaagaaccaa  25921 agacttggag ataggaacag agcctgaaat gaacagaaac tattctatac cccccatgaa  25981 cctagaaaca aatgtgtata gctaagcgta ttagtccact cgggatgctt taacagaata  26041 tcaataaact ggaatgcttc acagtaaaca tttatttctc acagttctgg aggctgggaa  26101 gtccaagatc tggtatctgc tgaggttcct cttactggtt tgcagatggc cgtcttcttg  26161 ttctatcctc acatggcaga gagcagagaa cagaccatct cttgtgtctg ttcttagaag  26221 aacattaatc ctatttatga gcactctacc ttcgcaacca aaaggcttca tctccaaata  26281 ccatcacttg gagatttagc cttcaacaca ggaattttgg gggtacacaa acattcaatc  26341 catagcactg agtctgtatg tgttgggaac tgattgataa attggaattc ttcaaattaa  26401 cttacatgta gaatacagta tttattaaag gataagtaaa aagaaatgtg ttaatttata  26461 gtgtatttat tattattaaa agtctatagg gcbgggcaca gtggctcatg cctgtaatcc  26521 cagcactttg ggaggccaag gtggggtgga tcacgaggcc aggagtttca agatcagcct  26581 ggccaagatg gtaaaattcc atctctacta aaaatacaaa aattaattgg gcatggtcag  26641 gcgcacgcct gtaatcccag ctacttggga ggctgaggca ggagaactgc ttcaatgaac  26701 ccgggaggtt cattcaagat cacgccactg cacttcagcc tgggtgacag agtgagactc  26761 tgtcttaaaa aaaaaaaaaa aaaagtctac agtaactgca attgtttaga atttaagcca  26821 acaagatatg ttttcttttc cgggagttgt attttttatc actgattgtc tacaattgac  26881 agtgcatgtc aaaaagcaga cttgtcgtgc tgcagtggct cacgcctgta atcccagaac  26941 tttgagaggg cgaggcagga ggattgcttg agcccaggag ttggagacca acctgggcaa  27001 catagtgaga tcccatctct aaaaaaataa aaataaaacc actcattttt gtcaatttta  27061 ttactgcttt taatttttct aaagacgatg tgctgctcca gctctgggta cacacatgcc  27121 cacgagagca agctcatgag agaagaaact acatcccctc tatccaccta tatttctaac  27181 gccttgcaca gtagctggca catagtggac atgaaataaa tatttgtgga ataaataagt  27241 gaagaagaat tttagaatac tttataagaa acaataaatc ttcagagatc aacatttcaa  27301 attagtaact ttatttacaa acctctcttc tgggttttat tatttactac aagtgcttgc  27361 aagacctgtt attgtacact catgtattcc tatcaaaggt aatcatcaga cattatattt  27421 cattaaataa tttaatggtg ctttctgttc tttattcatt aatttttttg tgtgtgtgtg  27481 agaatggagt ttcactatgt tgcccaggct ggccttgaac tccagggttc aagtggatcc  27541 tcctgccttg gcctcccaaa gtgctgggat tacaggcatg aaccaccatg tccaacaatg  27601 ttttctgctc tttagtaagt ctagccatat taaattttat gtgttttttt tttctttttt  27661 gagactgagt ctcactctgt cacccaggct ggagtgcatt ggcgcgatct ccactcagtg  27721 caacctccgc ctcccagttt caagcaattc tcttacttca gcctcctgag tagctaggat  27781 tacaggcacg taccaccaca tctggctatt tttttttttt ttttttttga gacgaagtct  27841 cactctgttg cccgagctgg attgcagtgg catgatcttg gctcactgca acctccacct  27901 cctgggttca agtgattctc ctgcctcagc ctcctgagta gcbgggacta caggcatgtg  27961 ccaccatgcc cggctgattt ttgtatattt tttaacagag atggggtttc attatgttgg  28021 ccaggttggt ctcgaactcc tgacctcgtg atccacccac cttggcctcc cgaagtgctg  28081 ggattacaga tgtgagccac cgagcccggc ctaatttttg tgtttttggt ggagatgggg  28141 ttttaccatg ttggccaggc tggtctcgag ctccggacct caggccatcc acctacctcg  28201 gcttcccaaa gtgctaggat tacaggcgtg agccactgtg cccagctcat attacatttt  28261 aaatggaggt agaatatcaa cctgaattca ctaagagaat gcaggacaaa ttgccctgat  28321 atcctgacac aaaggtgaag caggactttt ttgtaatttg aggatttaaa agcatggttg  28381 ctccaggcca ggcgtggtgg ctcctgcctg taatcccagc actttgggaa gccgaggcag  28441 gcggatcatt tgaggtcagg agttggagac cagcctggcc aaaatggtga aaccctgtct  28501 ctactaaaaa tacaaaaatt agcbgggcgt ggtcaggcgc ctgtaatccc agctacttgg  28561 gaggctgagg caggagaatt gcttcaagga acccaggaag cagaggttgc agagcccata  28621 tcgtgccact gcactctagc ctaggtgaca gagcgagacc agcctggcca acatggtaaa  28681 accccgtttc tactaaaaat acaaaaaatt agcagggcaa gctggcgggc gcctgtaatc  28741 ccagctacac gggaggctga ggcaggagaa tggcgtgaac ccaggaggcg gagcttgcag  28801 tgagctgaga tggcgccact gcactccagc ctgggcgaca gagggagact ccatctcaaa  28861 aaaaaaaaaa aaaaaaaaag tatggttgtt ccagtcctgg gaaattgaaa tagggggtaa  28921 aaaggctggt gggtgtggta ggcagaataa ttacttcttc cctctcccaa gatgttcagg  28981 tcctattccc catcctattc cctggaacct atagctagat tgccttatgg ggcaaaagga  29041 atttttcaag tgtgactaaa tttagaatca tgagttagag agattatcct ggattatctg  29101 tgtgggttta atgtaatcac aggggtccct agaaagaaaa gagggaagca gaaaagccaa  29161 aggagatgga atgatgggag ttgagatcag tcagatttac agatgcaata ttgtttccta  29221 taaattctgt ggtgaaagaa atgctatatt gttgctggct ttgaagatgg aggaaggggc  29281 tgagagtgaa ggaatgcaag tgaccttaaa ttggaaaaga caagaaaata attggccctg  29341 tagaggttat aaaagaaggg tggtccttct gacacactga ttttagtccg atgagattga  29401 ttttgaactt ctgacttcca aaaactgtaa gacaatacat tagtgttatt gtaaaccact  29461 acatttttgg taatttgtta cagcaatagg aaacttatat agtgggccct gggatccatc  29521 tgccctagcc gtttatctaa aacaaaagat cttataggga aagcaaacaa acaaacaaaa  29581 aatacagaaa caaagcaaaa caaagcaccc ctatgctctg agcttgggcc tggtaagggc  29641 actatgagcc catgatttag catgttgctg ggaaatctcc ttccccctgt tgagttgcca  29701 gaatcgtgga agcagatggt gtgggggatt caggctcctc cactgctttt ctcagccaga  29761 cctttgagga gagcttggct gaagtcttcc aagctttatc cccttgtagc cattgttttg  29821 agccatctca aacattaagt agctcttgag ggttgaattg agtccttcct aaagacagac  29881 taaagtccta gtctccagga cctgtaaatg ttcccttatt tgtaattagg atgtttacag  29941 atgtaatcaa attaaaatga ggtcataccg gactagggtg ggctctgatc caatatggcc  30001 ggcatcctca taagaagagg agaagagaca tagacacata gggaaaagac cgtgtgatga  30061 tggcagagat tagagtgatg tgtttacaag ccaaggaatg tcaaatattg ccggcaatat  30121 cagaaactaa gaaaaaggca tggcacagat tgtctctgag agcctctcag agagtatggc  30181 cctgctgaca ccttagtttc agaggtctag catccagaac tctgagagaa cagatttgtg  30241 ttgttttaag acacccacca tgtggtaatt tattacagta gcccttaaac taacacagtg  30301 accttgtgtc ttctgccaga gggatttgat cacactggtg aggaagggtc ctggtccata  30361 ataacccaaa tttctgccag ggaagaggag attgaaaggt cccagtgatc ttggcctatt  30421 tacttgggag ctcttccaca gaacaaatga actcctgaag atgagctgct acaaggattc  30481 tgtgctttgg acagaattgc acttgtctct tccccctgct gtcactccct gactaggaaa  30541 ggtccaagct gtgaaggaat cccccccaga agagacttgt aagcattaaa gacctgtgga  30601 aaactaagag ggagggtgga tagaggagtc tggagaccga ctaaccttct gagctgctta  30661 ttgcctgaag tgggggtgga gtgggctgca aacactgttg tatttggggg acacatcaca  30721 gatgcttatt tgcaccttgg actttgtcag gacactctgg ttacagcaca actttgtgaa  30781 catggatcac aagatacttg gaaaagcagt gtttgcatta atcagattag gattagctaa  30841 aattttaatt aaagaaccag agagtacttc agaggcaagg agatgatagt tacctgggat  30901 tacttgctat ttgtgaaacc aaccagctga ccacttgtgt tgtttgtccc aaggtataat  30961 aataactaga tgtttgcata ttgtgattgt ttctgttcgg atttaatggc tgatctattt  31021 atcatattaa aagagggatc aagttcaaag atttcaatgc tctttatctt ctttctatat  31081 atgatattta tttttaaatg tccatattaa atatacatat atacacacga ttctcagaat  31141 tacgaagaat gtgcbgtgta gcattcaatt atatatataa tttttttttt gagatggagt  31201 ttccctcttg ttgcccaggc tggagtgcaa cggcatgatc tcgggtcaca gcaacctctg  31261 cctcccaggt tcaagtgatt ctcctacctc agcctcctga gtagcbggga ttacaggcat  31321 gtgccaccat gcbgggctaa ttttgtattt ttagtagaga cggggtttct ccatgttggt  31381 caggctggtc tcgaactccc aacctcaggt gatccaccgg cctctgcttc acaaagtgct  31441 gggattatag gcgtgagtca ccaagcctgg ctccaattct gtatattttt aaatgtaagt  31501 ataaagatca aagatacaaa gtatattcac atatcagttt ccatgttgtt attattatta  31561 ttatttgcca ttttaaccat ctccagatga agaaaactga atgtaaagtt aaatatctcc  31621 ttaactttta ctctatttaa aaagagactg aattatttgt gaggtaaccc agttgtagct  31681 gttctactct tctctactgc tagattttgg aagaaccaaa aaggaataaa gcaaagcatg  31741 acacagaaga gaaagcagaa ttatactgta gtagtatgct catattttat cagagtttgc  31801 ctgtactttt gctgattttt ttttctccta gcttggacat tttaaaggct tattttaaat  31861 ttatctcttc tgtattaaca ggtgagaagt ggacaaatca atgtataaaa actactatgg  31921 ctatcatcat ttagaatttt gtcttaaaag taattggatt tctggggtcc tagacacata  31981 atgattagag atcatgccac cagttctata tggagccatc tcaattcatc ctttctcaat  32041 ttatcctttc caggcatttt tcttgaaact gcctaagtac tggcgtctcc ctacgactat  32101 tatatctgaa aacacattca gttttcaaac cagctgaatt ttatgcctga ctattccttt  32161 taacttatac caatgaaaat cctttaataa attcactcac aattgctcca ctttctcaaa  32221 cagagcacaa agcatctaac aatatttctt catgattgat agcatacaca ctcttgactt  32281 catattcttc aaaatcttgg tatttttata agcattagtg cctttttttt ccccagtcag  32341 aagcactgac ggatttattc tattgggtgt tgtcttctgt ttggtcttta gcttttctta  32401 gctgtgatcg tttattgctg aataattaag ggcaattctt tcccactgaa atacttttca  32461 agttaaacat tttttcctta aatttttgcc ccaggctact tctagatcca gcgttgttcc  32521 agcttactga gcattccaga gggctaaggt ccaagttagc caaggtttta aaatgttgac  32581 catgtggacc tgaattcttt ccagttacat atttgcatac ttttaacagg agtggttatt  32641 tctcgtcaaa agacagaacg ctggaaatac cagggcaaaa ctatgtgttt ttttcttggt  32701 gatatcttga tcttagcatt ttactctctc ttcctggttt ctagcttgac ctttgtattt  32761 tagaggagag taatagagta acagtgcact gagaagcaat gggacatgac agaatagttt  32821 cagcagtgaa agtcagggaa gctggtttca accattcatt cacaagctta aaggactttg  32881 gtatctgact ttgtggatgc cactttctca tctgtaaaat aagggggttg gatcgtgtga  32941 tttataaggg gctttcttac tttctaacat tccatattct ataaagacag ttaaagtctc  33001 cagagagtaa agaatgtaga aaattcctga aatttactca gctcctttat tcctaaatat  33061 ttttgaattc tgaaattatt attattatta ttttttgaga tggagtctca ctctgctgcc  33121 caggccaaag tgcgatggca caatctcagc tcactgcaat ctctgctgcc caggttcaag  33181 tgattctcct gcctcagtct tctgagtagc tgggattaca ggcatgtgcc accatgcctg  33241 gctaactttt gtattttcag tagagaaggg gtttcaccat gttggacagg gtagtatcaa  33301 atttctgacc tcaagtgatc cacccgcctc ggcctcccaa agtgctggag ttacagccaa  33361 agcacctgac ctgaattctg agttttgatt ctgttttttt tttttttttt ttgagacaga  33421 gttttgctct tgtcacccag gctggagtgc aattgcacgt tctccgctca cagcaacctc  33481 catctcccgg gttcaagtga ttctcctgcc tcagcctccc aagtagatgg gactaccacc  33541 gtgcctagct aataattttg tgtattttag tagagatggg atttcactgt gttagccagg  33601 atggtcttga tctcttgacc tcgtgaccct ccctccttgg cctcccaaag tgctgggatt  33661 acaggcgtga gatactgcgc ccggcccata ctcacagatt tctttgtgat attatctcat  33721 ttgttttcac cacacccaga tgatgtggat ggtaggagaa atcccatgcg aataagtgga  33781 atatgttagt aactgcttcc ttgggtcctt ttgcctctgg acttaactct ttttttttga  33841 gacggagtct tgctctgtca cccatgctgg agtgcagtgg cgcaatcttg gctcactgca  33901 acctctgcct cccagattca agcaattctc ctgcctcagc ctcccgagta gctgggatta  33961 caggcatgtg ctgccacgcc tggctaattt ttttgtattt ttagtagaga tggggtttca  34021 ccatattccc caggctggtc tcaaactcct gaccttgtga tccacccacc ttgaccaccc  34081 aaagtgctgg gattagaggc atgagccact gcacctggcc tggacttaac tcttaaatga  34141 tgttacccag gaaaaccaat ctatgactaa ggcaaaaaaa aaaaaaaaaa aaaaaaaaaa  34201 aaaagttgca cagagaagag tggaaatatc agtaaatcag aagctaggca ggcctaatcc  34261 ctaatccact tggtgacctt ctgcaaaaca cctttctgtt agccttttca cccgtgaatt  34321 tttttttttt tttgagacgg agtttcgctt tggttagcca gactggagta caatggtgcg  34381 atctcagctc actgcaacct tcgccttctg ggttcaaggg attctcctgc ctcagcctcc  34441 tgagtagctg ggattacagg aacctgccat cacacccaga taatttttgt atttttagta  34501 gagatggggt ttcaccgtgt tggccaggct ggtcttgaac tcctgacctc aggtgatcca  34561 ccttcctcgg ctgcccaaag tgctgggatt acaggcgtga gtcactgtgc ctggcttact  34621 tgtgaaatta aagcttcaac ttttactcct taggaacgtc tcacaaattt ccacacataa  34681 atctaaagta gacactcctg cttgccaaaa gcatactctc taaaacattg gttctcagac  34741 ggacatagtg gctcatgcct gtaatcccag cactttggga ggccgagacg ggtggatcac  34801 ttgagatcag gagtttgaaa ccagcatggc caacatcgtg aaaccccatt tctactgaaa  34861 atacaaaaaa aattagccag gtatggtggt gcgtgcctgt aatcccagct actcgggagg  34921 ccgaagcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc agatcccgcc  34981 actgcactct agcctgggag atagagcgag actctgtctt ggaaacaaac aaacaaacaa  35041 acaaacaaaa aaattggttc ttgagcaggg caatttcacc tccaagggga catttgacaa  35101 tggcbgggga catttttggt tgtcacatct ggggttgggg agtgaagtgc tattggcatc  35161 taatacgtag aggccaggga tgctgctgaa catcctgcag tgcacaggac agcccctgac  35221 agcattaaac agtccaaaat gtcaattgtt ttttgaggtt gagaaacgct ggtctaaaag  35281 aaatgacagg acaggtggct tggctcatgc ctatcatccc agcactttgg gaggctgagg  35341 cgagtggatc acctgaggcc agtagcttga gaccagcctg gccaacatgg tgaaacctct  35401 tctctactaa aaatacaaac aatagccggg cgtggtggcc cacacctgta atcccagcta  35461 ttcagaaggc caaggcagga gaatcgcttg aacccggggg gcaaagattg cagtgagcta  35521 agatcatgcc actgcactcc agcctgggtg acagagtgag actctcaaaa aaacaaacaa  35581 acaaaaaaac agaaatgact caaatgttta cagtgattac ttctggatgg gattatgata  35641 attgtttctc tactgttcta aaaaactttc tgttctttcc aaatgtttaa tattgagcac  35701 ttattttaca atcattaaac aaagaaatga caacaactgt taaaaaaaaa ttcttaagaa  35761 ctgaaaggca aacaccacca ccactaaagc catgtccccc agatctaggt tgtgagtcac  35821 atgataccga cttcagaggc agcatgtctc aaggcctctc caatgtgtgt cagggacagc  35881 agtgggagta gggccctctg agtcagcctc tttgacctgg gatgctgcag gagatcttag  35941 caaacattca agattttcac tgagtcattt gcctgtggca ttgatctgct cactcaagtc  36001 ttccggtgtt ttggtgtgag ggaggctaaa gaggaaaaac agcbgtttag tttctcattg  36061 atttgtattg tcattgagca atacctggag cccaagtgga tgtcttttat tctgtggcct  36121 ccacagctgg gtcagtgtgg aaggcttcag accatgagaa attgttcctg ggagtcaatt  36181 attttaataa gtgagatatc agagtatatt cacagaaaga ggcttccctg gcactgtaag  36241 ggcagccagg aataaaataa aaatgcttct tcagtgaaga taattgtcca aattgaagac  36301 ataggaaata tttctaattt gcctgtgtat ttggtgaaca tttctctctc tctctctctt  36361 tctctctttc tctctctctc tctctttctg tctccataaa tgaagacatg ggaaaatcta  36421 ttaaaaatta aattaaaatg caacactttt acataaacaa aattcccaat cactctcctt  36481 actttacctc agcccaacca aatgtgagtt aaatctcttc cctttcccat gggacactag  36541 catcttggtg gcccagctca gtagctaagc atagagtaat gagtttgtta aataatttca  36601 attacattgt ttttgagatt ccagggtcac agggaaattc tgacctgaat tatctggatg  36661 aactctcaca attgtgcact gccttgttca aatttgggaa gtgctgagaa gcactcatcc  36721 aaggggtaga tctggacttc agctcatgca gcataataga atttcaggct cagtgatttc  36781 taatctgtta ccacttgcca ttttctactt gaagagggca gacaccttca ctgatctctg  36841 tttctatttc atcttttgaa aaatcgggat gataatggtt atctggttta catgctttta  36901 catgcttgtc aggagttatt ttaaagcact ttacaaatat aaaaatgtac aataaaattg  36961 cagagtcgga tgcagcaacc cctgtatcct ttgaggaatc tatcacaatt catacccctc  37021 ccaagccaac ttttctggta ctactctgga aaattgtgct tatacagtta aaatttttat  37081 tttcaaaaag ttgtgtaatt ccctttttca accatttttt tttgttataa gaaatgcaat  37141 taaaaacata cttttctttc caaatagaag agcctattct gccttataag aattgtttga  37201 aagattgaag gacaaatgaa gtcatacaac ttctctgata ccatattgaa ctcaaatgaa  37261 cacattttga ggtaagaaat gagcctggaa gatttttctt tttttttttt ttgagatgga  37321 gtcttgcttc gtcgcccagg ctggagtgca atggcgcaat cttggctcac tgcaacctcc  37381 gcctcctggg ttcaagtgat tctcctgcct cagcctcctg agtagcbggg attacaggag  37441 tgctccacca ggcctcacta attttttgta tttttagtac agatgggttt tcaccatgtt  37501 ggccaggttg gtctcagact cctgacctca tgatccaccc gccttggctt cccaaagtgc  37561 tgggattaca ggcgtgagcc actgtgcctg gcaagagata gaatttttca caaaaataac  37621 tcataccaga aactttgtag gcccccaccg atgcccataa tctttaggaa acaaactcta  37681 gtgtcaccta tttcctgata ccttctgtaa cgaccaggtc atattctgag ttcctacagc  37741 actcagtgtt tctcatcgga gctgtagcaa tggagtaata aatggcactg ctcaggaaga  37801 gagaattcag aaagaaaaga gcagggccta gaaaaggaac aaacttatcg gatgtgtaga  37861 gaaagaatct gcaaagcaag taataaaatc cagaaaaacg tggtatcatg gtggtcacaa  37921 aaaaaagagt ggttaaattt tcgaaaatgg agacaaacca ctcaccatga tcgtgccatc  37981 tgaatagaaa cacagaaatg atgacaaaaa aatggctaaa gaaagaaggt caacaaccat  38041 gtccaatgct ttggatatta agaagtgttc agatggattt agcaagtaga aagtcactga  38101 cacttggtgc acaaccagac ctcaatgtat ttaggaggaa actgttattt tggaacaatt  38161 gaaagctttc atttggctga gaaatatcaa ctcattctta aataggtatg ttagaaggag  38221 cctctgggcc tgatatctcc ttgattacaa ggaaaatgaa taatagttgc gtctgataac  38281 catgacatat cacccctatg tttgcttgta gctttcagca gctcagaaca ttgttgaaaa  38341 cactcattat cccaatatcc ccaacaggga agtgttaaaa cctgccttgt gcaactgtca  38401 atctctgatg attagataaa aacaattatg tcatgagttg tagctattgt tatttacttc  38461 ccaagagcca gattacacag gtatctgatt gctgaagcaa tgtctggatg taccacgaaa  38521 ttccacatgc atgtacagta taaacacctc tggctatcac cttatctaat tttgatcaga  38581 tacaggttaa tcccctcctg tatctttata tgtcctgaat ttgcctcatc cacctgaact  38641 ttgccataat ttactctcaa tttgtatgtg tctgtgatgg agttgttgtc attttccttt  38701 tctttttctt ttttttgagg ccaagtctct ttctgtcacc cagactggag tgcaatgacg  38761 cgatctcagc tcactgcaac ctctgcctcc cgggttcaag taattcccct gcctcagcct  38821 cctaaatagc tgggactaca ggtgcatgcc accatgcctg gctaactttt tgtattttta  38881 gtagagacgg ggttttaccg tgttagccag gatggtctct tgatccgccc gcctccgcct  38941 cccaaagtgc tgggattaca ggcatgagcc accgcgcccg gcctcatttt ctctatctgt  39001 ctgcttaatc aggttttgca agtttcacat ttcctcaact aaacttcatt ttaccaccca  39061 agcaaacttc attataatta ttttattttt ctgatgacat cagatttctg taggggtacc  39121 tattagctag agatacttag attttatttt cccagcatgt gactatttcc cattctatac  39181 aacacaatgg caagagcagg agtatgtttt tggacaatta aagagagaaa aggccgggcg  39241 cggtggccca tgcctgtaat cccagcactt tgggaggctg aggtgggcag atcatgaggt  39301 caggagatca ggagattgag accatcctgg ctaacacggt gaaaccccat ctctactaaa  39361 aatgcaaaaa attagccggg cgtggtggtg ggcacctgta gtcccagcta ctctggaggg  39421 tgaggcagaa tggcgtgaac ccgggaggca cagcttgcag tgagccgaga tcgtgccact  39481 gcactccagc ctgggcggca gagcgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaaa  39541 gagagagaga aaataactca gcttcattta gatttctatt attcttctct gatccatata  39601 gtggatgttc acagaagtgt aggaaccaaa actatgcaag ttaaactgtt aattttagaa  39661 gtttatagca gtgatgtgga aggctgacca aagttggcgc tttggtctca ctataagcca  39721 tagtaataaa tacattaaca atgtccacaa acaacagtag acaccattta gtaagggctt  39781 gctccaagcc aggcactgtt ttcagcttaa gtctcacagc cttgtgaagt agattctgtc  39841 ccatcttaga gcaagttggt ctgaggatcc tcaagggtaa ggtctcttgc caaaggtcag  39901 cagaggtagt gagttcagaa ctgggattta aatccaggct gttctatttc tattccacaa  39961 ttctgcctca actgcttctc tacattttag gcacacgttt gaatactgaa aatttgggtc  40021 acagagttgg agatgtttct tcttctaggc cccaaaccgg agcggggtgc agtggctcaa  40081 gcctgtaatc cgcactactt gggaagctga ggcgggagga tcgcttgagc tcaggagttt  40141 gaagatacag tcagctatga tcctgccact gcactctagc ctgggcaaca gaacaagatc  40201 ctatctctaa aaaaaaaaaa aaattaaaat tttaacacaa gggcccaaac aagtcaacag  40261 taattacaac atgatcttta ctactgtcta ataacatctc acagtgcttt aaacatacgt  40321 agttaccatt ctgtccactt ggttgcctgt aatattaact cagtaagtag gaatacttcc  40381 tgccctgact aatatactca taaatatatg ctctaagtca agggtcttgc aggttctgat  40441 ttaaaaaaca caattttttt gagggtcact ggctttacat tatctcattc ttttcaagtt  40501 cctttgtacg taaaacatcc tatgctcagt tatatgatct gttcaacctc ctgcttgaca  40561 gatatgaaaa cagtgctctc atgtaattta tgtaatttac atttttacat atttagcagt  40621 acacctttgt gctatgttat attgtttgag aactaatctg tttttctgat ggctggaagt  40681 ctaagtgaaa agattataca tgaaaataat tcatgtttat tatcactagg agaaagtaag  40741 acaatttagt ttgattcaca agcatttgaa tccctattgt gtcagacatt gtattggaaa  40801 ctggggatac aaggaagata taacctcatc tctcagagtt ccctagttat cccatacata  40861 tatacaatta ttatttgtca attaaatttt ttttaaaaat ttagaaagga gtttccaagt  40921 aagaaaaatc atagcgaaat ggtataattg gtataataac agttaattag ctatagtatg  40981 aaaatacaga ggaagatcta actaagttgg ggattattaa agaaaattta aattagctgg  41041 gtgtggcggc agacgcctgt aaccccagct acttgggagg ctgaggcagg agaattgctt  41101 gaactcaggt ggtggaggtt gcagtgagat gagatcactg ggtaacagaa caagactccg  41161 tctcaaataa aataaaataa aaaataaaga aaattggaca gagatgtggc atttgaactg  41221 tctttcagat taagaagaaa gttactagtt agccaattca aatataagat ttacaaacat  41281 agagtacagc atgagcaaag gtgtggaggt acaaaaagaa taatgttttt gaggggagaa  41341 tagcaagtac tctgggggtg gccaaagttt gagttgtgtg gttttggtgg tggatggaga  41401 tgcaggaaga ttaggaagta gattgagatc agattgagaa aggtcttcca gaccagatga  41461 aaaattttgc catatttagg caatagggag ccccagaaat tgttcaacca tcatcagctt  41521 tacatttcac tatggtaatt tggcttcata agaagcatgg gttggagatt gataagagca  41581 gactccaagg ggccaattca ttaaactcaa ctgccaataa tgcaagagac aatgaaagcc  41641 agaatgaaca cagtgaccat ggatgccaga ggcatttcta ggatttttgt agaggactta  41701 agagaccatt tgggagggga ggaaggcaga agataagggg aaagaaggag ttgatatctt  41761 tgatgactga tggcactttt gctaagatga agaataaatg gtagcaagaa taaattgact  41821 gggcgcagtg gctcatgcct gtaatccaac cattttggga ggctgagatg ggtggatcac  41881 ctgaggccag gagctcgaga ccagcctggc caacatggtg aaaccccatc tctactaaaa  41941 ataaaaaaaa ttagcbgggc atggtggcgg gtgcctgtaa tcccagctat tcgggaggct  42001 gaggcaggag aatcgcttga acctcgaagg tggaggctgc agtgaacgag atcaagttat  42061 tgcattccag cctggacaac aggagcaaaa ctctggctca aaaaaaaaaa aaaaaaaaaa  42121 aaagtataaa ttgggggagg ggaggagata taggattcct attggaatgt attgagtttg  42181 agattccagc ctggacatat ggcactcttg aattgtttcc taggcgatca tatcactgtc  42241 ttgatgatat ctttaatcac acatatcact tgtggggaaa gaagaaactt caagagtttt  42301 acacaccaat cctttacttt gccatctaga caaattatat ttttaccaat gccatttttt  42361 gttgttattt tgtgggttct gcttaaaact tcccctatat ttttctaatt atggtaacct  42421 agggaaaaca tcaaattatg ttgataaaat tggctacaat ctggctctaa tgataatagc  42481 ttagaatcat gaagcagcaa tattttatcc tgagagcaaa caaactttat cctgaacaca  42541 tgtgttcttt tgccttattc atctaatatt acttgaaact tttatttttc cactttgaat  42601 agtagattct gccaagtgtt ttaaaagctt ttctcttttt aggggaggag gggaacagct  42661 tttctccctt ttgtctgata actgaggagt gaagatttaa ttggtgagaa aaatatacac  42721 actataaacc tcagaatgtt cccactgctt ttaatgtttg atgtgcctga cagattaccc  42781 tttcaaaaca gataatagga taggtggtgc tggaaaaaaa cttttccatc caagacaaaa  42841 ccacatggac attgaaaaga actggcattt gcctagacat ttagtggggg acatgtcctt  42901 agggcacaga ttccatagtg aaaggctctt ctcccccttc cacacactcc agctctctct  42961 agaaggtata atggaaagaa ctctgagcaa gaatcaggaa gttggccttt gttcctgact  43021 gtgccacttt gtggaactgg gcagaactta cctcattctg tgctttagca gcttcatttg  43081 caaaaattaa tgattacctc aaatgatttc tgattttagc caaaattaaa tacagtagtt  43141 ttaaaacaac tgctacatat taactactta cgtatgtaat tttgcactca aaataaatta  43201 tattatggaa aagaaactca acctatgtta accatccctg tactgatgag gaaactaaga  43261 cttaggaaaa agaagtgatt tactcagtat tgggcagtta gtgagcattt ttgagccaag  43321 gtcttacttt aaccagagac ctttgcataa tattgtactg ttactaaaca ctttctatta  43381 tttgactaga ggaacacaac atattgatgc atttgaaaca ataaaataat aaatattttt  43441 ccttaccctc ggcagaaaca ggatgatgag aaacattgac taaaaattta atcaagcctt  43501 aaggacaaat agtatcacag ttttgaatag gagattgggt accttggaag taattatgaa  43561 gaggtgtttt aactcagcag taggctcttt cttattcctg ctaggaatga agaagcacaa  43621 attgaaagtg aagaaggagg aaataaaaca ctgactctat gtgtaagaaa ggtgacttgc  43681 aaattatgag gcagttagga aaatgtttat tttttcttat tttataggct gtatatattt  43741 gagaattaat aattgtcctt tggagggtgt gtgtgtatgt gtatgttgga gctttgtgtg  43801 tgttttagtc cattttccta ctgctatgtg aagaaatgcc cgagacggta atttataaag  43861 aaaaagaggt ttaacggact caccgttcca catggctgtg gaggcctcac aatcatggtg  43921 gaaggtgaag gaggagcaaa ggcacatctt acatggtggc aggcaagagc gtgtgtgcag  43981 gggaattgcc ctttataaaa ccatcggatc tcacgagact tattcactat cacaaggaca  44041 gcatgggaaa aacttatccc catgattcaa ttacctccca ccagctcccc tcaagacaca  44101 tggggattat gggagctaca attcaagatg agatttgggt ggggacacag ccaaactgta  44161 tcagtatgcc tgtgtgtatg catgtgcacg tatataaatt ttttcactag tgactgatgg  44221 accatctata aaataaacaa aagagaagag acagggtctc actttgcctc ctaggctgga  44281 atacaatggc atgaccatag ctcattgcag cctctaattc ctgggctcaa gtgatcctcc  44341 cttctgagta gcbgggatta caggcacgtg ccattatgcc caactaatgt tttgtttgtt  44401 tgttgtggag atgggagatg ggagtactgc tatgttactc aggctggtct tgaactcact  44461 cctggcctta agtgatcctc tggctttagc atcctaaacc actacaatct taaaaaggac  44521 cagtttcctg gattacctct ctccctccat catccactat ctgccgtcaa ctctatagag  44581 tcaagggcta tccctgcctt ttcaatagaa gccctcaaga agtcactcca tagggactat  44641 cttgggcttt gggaagtgta cagggttggg gtgggtggga aggtgaggag gaaaggccac  44701 tgtttcaggt ggggttggag ggagatggaa aatggaccac agaggttcag agaacaggcc  44761 ctttgtggaa agggggagac caaataatgc tgcgttgtga aaggtgaaac aggctgcaaa  44821 cagaaggagc ccacaggaag ccctgctctg agcagctgaa cattctgggg tcctcagact  44881 ccgataaaaa agcacattta gcctacagct ttatgccctt cctcctaccc ttgtggactc  44941 tgccacagac atgccctcca gattgattct atccacttgt ctctagtcta ctgctactat  45001 tttagtctaa ggccttctcc ccgctttcct gggttatggt cacagactcc tatctgagtt  45061 cccagcacca ggtgcccagt tgttttcatc tcttaacaca ttccacatat tatagcaaga  45121 gagatctttc tcaaatgcaa atcagacctt gttgcatccc aatctcaacc cctttagttg  45181 ctcttctctt tgccctcatg gtcaagttca agctctctag tgtgggggca gatgttcctt  45241 tataattttt ctgcttatgt ctcctgcctc aggcctcaca attctccacc tcacagatga  45301 tgtctcagcc atgatgagtt cctctcaaat cctttaggtt tcagagatgt catttcccct  45361 gggaacattt tcctgactcc tcgttccaag catatgtctg tctttatgtt cccatagcac  45421 ctgatcattg gatcatggta gggtttatca cggtctcgta tttgtctgct tacttgtctg  45481 tattcttcac ttctcaaata tgtcttcttt gttcatcact gtaactcctt tccccagaat  45541 gttctcagat atttacaccc atcttccccc tctgtgaagg gaataaatgg atatataaca  45601 ctgtattagt ccattctcat gccactatga agaaatatcc aagactgggt aatttataaa  45661 gaaaagaggt ttaaatgatt acagttctgc atggttgggg agaactcagg aaacttacaa  45721 ttatggcaga ggcacctctt cacggggtgg cgggagagag aataagtgca agtaggagaa  45781 atgccagatg cttctaaaac tatcagatct catgagactc actcactatc acaagaacag  45841 cacgggggaa accgcccccc atgatccgat tgcctctacc tggttccacc ctagacatgg  45901 tgattatggg aattaaaatc caaggtgaaa ttttggtggg gatacagagc caaaccatat  45961 taagcaccat cctcaaaata gccttccagc tgaagacagc taaggcactc atgtagtctt  46021 attttgtctc agacaaataa ttttaccttt gaatcattgt tcattaatct agattttaac  46081 ctgaggccct aaaaattgtt tatcatcttc tgggagatct tactcctaga tggtgtttta  46141 ttccacaggt taaatttaaa cttgggccaa atctccatcc ttgtggcctg tgagtactga  46201 atttgggact gaaagcctgg gactaactgg aagtgtggaa aaggaggagg gtgtggcgct  46261 gccctcaatg attttttttt ttttttagga tttctggtgg aaaaggagag acactcagga  46321 atccccagat aaacatggtt tagcttttgt agtcagatcc tttccccaaa tttactgctt  46381 ctttctccac cacttctcaa ccccccaaac tgaacttgcc tcttcaacac actcccttgt  46441 gccctataga cagtcacaag cttgacctat agagagcatg tatttcttga ggcaacgaag  46501 gtaggaaacc ctattctaaa atgtttctta cacttttggc tctgtctaaa ttctccattt  46561 ttcaattaaa atggaaacga gattagaatt ctattctagt tatgaatata atcagaacac  46621 aataaagcag aaagattgct tcaggctctt ctgttaacgt tacatttatt caacaactct  46681 ttatggggac ttgctatgag tgaggcacca ggctaggcac cgcagctaca aaggtgaaga  46741 gaacataggc tcttcttcaa agaaacttac actgtaagct ttatagttat gaaatcatga  46801 ttgcttacct taaatgttct tgacctacat tcttagatat tttgagtctt gagaaatttg  46861 tttatttttt tcattattat acaatgtcaa ttagctcagt ggaatccaag atgttcggct  46921 agccttctga tccaagatag tggaccaaac atttgtattt actcattgtg cccctccata  46981 cttctctgaa ataaaagtgt agatcttcaa aattaaacat atctataaag caaagggaac  47041 agaaggggac attatcagca gattagacat tccaaaaatt ttttagaaaa taaaagctaa  47101 attgaatagt aagacacgga attattagat gtgtttggaa aaccaacagc atgaacaaga  47161 taatccaaga aaaacaagtt gtcccttggt gaaaatggaa ggaatttgag aaatatagaa  47221 gtgaactaaa caataaatac agtcatccct tggtatctgt tggggactga ttccaggacc  47281 tccctcagat accaaaattt ggatgcccaa gtctctgata taaaatggta cagtatttgc  47341 atacagccta tgcacatcct actgtatact ttaaatcatc tttagattac ttataatacc  47401 taatacaatg taaatgcttt gtaaatactt gttatattgt attgtttagg gaataatgag  47461 aggaaaaaaa gtctgttcat gttcagtaca gatgcaactt tttttttttc cagaatcttt  47521 ttaacctatg gttggttgga atccacaaat gtagaacccg gctacagaga gctgactgta  47581 attaaaacca acagcttcta tttggtatac tgaaagagaa ttgggaaatc attaaatcca  47641 taaaataaga acaggatgga gtgaaaaaag ctggactctg tgacgaaatg gacatatgta  47701 tggataagaa tcaggaaagt tttcataaag gaagtgccaa actgagctag ttggccaaat  47761 gaactattct ccaggtggat ggggcagggc atttaggcag aggaagcaac aaagcacaga  47821 gtgaagccca ggaaactaca ggtagctgca gggagatgac ggggctacag tgtgcatgga  47881 gagaggccaa catggtgagg taggcaggag gagctcctga agggctccaa cctgggaagc  47941 caggctaaag agatggcatt ctatcttgtc agtaataaga agcattgaca ttttgtagag  48001 atgatgaatt gaggaaggga tttatgtggt catttgtggt tctggctgat ccccctgagt  48061 gctgtctgct agaaggattc caagggttaa gtcctgaggc gtgaagaaga accgatctgt  48121 aagatagctt aactaaggtg gtagcattgg gataagggtg tggggtgtgt gtgtgagggg  48181 gatacaaagt tattaaggtg gtagaattga tggcaacatt catcttgaca gagaatacag  48241 gatgaggagc agatttcaga ggaatataat gagccctttt ttagatcttt gtgaatgttc  48301 agaaatggca gcbggtgttg cataattgca aaattagggc ttagttagtt attggcttct  48361 gagaacgtaa ctgcagtttt tttctttccc tctgccccac tctttgaaag ggggtggggc  48421 tcaaagagta gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtggtaaa tacttatata  48481 caaatttctt tagatttttc tttatctcct tcactccttt tcaacatttt ggctggttgt  48541 tctgatatta ccaaggtaat ccacaattat ggcaaatatt caaacaaaac aaattataga  48601 aagtccagaa aaaaaaactc tgaaatacct tttccagaga ccaccatcat gaacagtttg  48661 gtctacagaa ttacaaatct tttgaagtat atagtatatt cttttatgtg gccattcatt  48721 atattttatg ggatcttagt attattgctt ttaaattcat ttcttatatt ttaaatttga  48781 aatacttcaa aatatgcaga aaagtagaga aaataacatt aacaccatat acttaccatg  48841 tagatttaag agaaatctac actttgccaa atttcctttt tttttttttt tttttttttt  48901 ttttttgaga cagagtcttg ctctgtcacc caggctggag tgcagtggtg cgatctcggc  48961 ttactgcaac ctctgcctct tgggttcaag caattctcct gcctcagcct cctgagtagc  49021 tgggattaca ggtactcacc accatgcttg gctaattttt gtatttttag tagagatggg  49081 gttttgccat gttggccagg ctggtctcga actcctgacc tcaaatgatc cacctgcctc  49141 ggcctcccaa agtgctggga ttacaggcat gagccaccgc acccgaccaa atctccattt  49201 ttgtaaataa tttttcagat atagaaaact acccaattat ggcbgggcat ggtggctcat  49261 ggctataatc ccagcacatt gggaggccaa ggcaggcgga tcatttgagg tcaggagttc  49321 gagaccagcc tggccaacat ggtgaaatcc cgcctctaca aaaaatataa aaattagccg  49381 ggcatggtgg caggtgcctg tagtcccagc tacttgggag gctgagggag gaaaatcact  49441 tgaacctggg aggcggaggt tgcagtgagc tgagatagca ccattgcact ccagactggg  49501 tgacagaaca agactctgtc tcaaaaaaaa gaaaagaaaa gtaagaaaac tacctgatta  49561 ctattacttc tctctttctc tctctctctc tgtgttctag aggtttgcag tatcctgaag  49621 ctggtgtgaa tcaacctcac gctttttttt tttttctttt tttttgaggt ggagtctcgc  49681 tctgtcgccc aggctggagt gcaatggtgc aatcttggct cactgcacct ccacctcctg  49741 ggttcaagtg attctcctgc ctcagcctcc cgagtggctg tgattacagg catacaccgc  49801 catgcccagc taattttttg tatttttagt aaagatgggg tttcaccatg ttggccaggc  49861 tggtctacaa atgtatctat ccataagcaa taccgtatat agtaatattt ttattattct  49921 attatttcta ttgaatgttt atattcatag tatcacactg tacacatcct tttgcaattt  49981 gctttcttta gaagcaacaa tatatttttg agatttatca tgttgctttg tgtagattgc  50041 ttactttttt tttttgatgg agtttccctc ttgttgctta ggctggagtg caatggcgta  50101 atctcggctc accgcaacct ctgcctcctg gattcaagag atcctcctgc ctcagcctct  50161 tgagtagctg ggattacagg catgtactac cacactcggc taattttgta tttttagtag  50221 agatgggctt tctccatgtt ggtcaagctg gtctcgaact cccaacctca ggtgatctgc  50281 ccgcctgggc ctcccaaagt gctgggatta caggtgtgag ccactgtgct tggccaatta  50341 tttacttttt aatttatttt atgatacaca atttgtctct ttatctcact ttattttttg  50401 attttttttt ttttaaacca ggatctcact tggtcaccca ggctggagtg cagtggcgtg  50461 atctcggctc actgcatccc ctgcctccca ggtgcaagca attctcctgc cttggcctcc  50521 tgagtagcta ggactatagg gtgtaccacc acatctggtt aatttttgta ttttagtaga  50581 gatggtattt tgtcatattg gccaggctgg tcttgaactg ctggcttcga gcaatttgcc  50641 cgccttggcc tccaaactct ctttattttt tagatattgt taacggtact atgggcagta  50701 tccttgaaca tctctctttg tataaatgtg aaagacattc atagacatgg gactaaagga  50761 ggtgcccata gtcaaccatg ctaggcattg acaaatggct tcctaaaggg gtaatacctg  50821 tgtacattgc cactagcaat ttgtacactt tcttgattcc tttcactctt gtcaaaactt  50881 actctttttt aaatttaaaa ttattggcca ggccatggtg gttcatgact gtaatctccc  50941 agcactttgg gaggctgagg caggtggatc acctgaaatc aggagtttga gaccagcctg  51001 gccaaacatg gtgaaaccct gtctctacta aaagtagaaa aattaactgg gcatggtggt  51061 gggtgcttgt aataccagat actcgggagg ctgaggcagg agaatcgttt gaacctggga  51121 ggtggaggct gtggtaagcc aagatcacac cattgcactc caacacaggg gacagagtga  51181 gactctgtct caaaaataaa ataaaataaa ataattgtca atattgttgg ttatgaaatg  51241 ctatctcatt attgtttaaa gaggcatttc ccttgataac tagtgaggtt gaattttgtt  51301 ttccagatgt gcatgagcca ttggtttttt tctgttatgc attttctatt catatacttt  51361 gaccacatga tatgtgcctg gtcataaccc atcaaactct tctttctctc agatacttca  51421 ctttatggaa atctttttca cgtttatccc tcaaacccag aattttgagt gtcatacctg  51481 ttctaacata aatttgagga aaatgaaggc taattcagaa taaagaacta tataagcaga  51541 tggacagtgt gttctcctct aaataggggt gctaggataa gaggcggtag gataaatgca  51601 cagcctcaaa atccaccacc cactaaagac ctcacagtac atgatgacat tagcatgctg  51661 tgccagcatt tctacctacc acgatgacct ggaatgaagg acaaaagggg caattgttaa  51721 gtcctgtgcg taaactttgg aagagaacat accttgcttt aaaccattaa gggggcaggc  51781 aatagattcc tgtacagggt ggcttagcca aaagtggctg gtcttgttct catttatatg  51841 gtttataatg attctaaatc attctcggag aaaaacagac tcatttcatc tccctttaat  51901 taggatttct gttactgcaa tattttagtg gcatttatgt caaatgtttt cttttgagaa  51961 cttctccctt ttactgtctt ttttctttta ttttaaactt ttattttagg ttagggggta  52021 catgtgaaaa ttggttacat aggtaaactc atgtcaagag ggtttgttgt acggatgatt  52081 catcacccag ggattaagct cagtactcaa tagttatctt ttctgctcct ctccctcctc  52141 ctactttcca ccctcaagta gaccccagag tctgttgttt tcttctttgt gttcataagt  52201 tctcataatt tagctcccac ttatatgtga gaacacgcag tatatgattt tctgttcctg  52261 cgttagtttg ctgatgataa tagcctccag ctccatccat gttcctgcaa aagccatgat  52321 cttgttcctt ttaatttact ttttgctatt ctgattagag agtggccatg ctccatgctc  52381 catatggata ttctttggaa acaaagcatt tttgaaatgg taggattggg gctagtaaaa  52441 gagaacagaa agaattgtga acagggtctc ctccagtaca gatggttaaa gaacacaaat  52501 agggaagtgt gatgagtgac ctccatttaa ttgggcgccc aagctcttgg ctgctccagc  52561 atgggttgcc atcctgactg atcccttggc tcagaaacag atatggtgct atcaggaaag  52621 caaggccaat atctgaatat tgcagcagag actgctccca tttcagaaag caacccagat  52681 taaagttgat gattcagttt caataaatgc ttcctttttt ataaaaggca tttaacatca  52741 ctctttcccc tggtaatatg gaattagctt ttgggatcaa ctggaaaatg tcagagggcg  52801 attgtaaaag gccacctgct aaccacagga agcbgggctg atacagaatg ccaggttaac  52861 ttaaggtcga taatggttac ttccttgtca ctttttacat gcatccttgc tctgcagtgg  52921 gggtcataag aagtaagatg catgcaaggt gaatttctag aagtcagctt ctctgagaag  52981 tattctctga ccatacattc ctactagtcc ccacatacgc tgctgatctc cccatcttca  53041 cccccattgt tgaaattgct ccctcattgt aactgttcac tcatctgtct ccaccataaa  53101 gcttaggctc ctagaaagtc aggaccagag ctagtacagt gccccatgtt cttatggaat  53161 gattttagtg ccttgagttt ggtgtggtga ccagagctgg tggccaactg tcgtgaggcc  53221 ccagtccttc tttttgtcat gctttccctc ccagcccctc cttgaccact ctttcacctc  53281 catctttcta cttatataga gacaaataat aagatgcttg tacaaagggt gtacttgtat  53341 tatcccattt gtgttgatat tccacaacag caaattaggt ttttttgttt gtttgttttt  53401 tgatggagtc ttgctctgtt gcccaggctg gagtgcaatg cgtgatctcg gctcactgca  53461 acctctgcct cccgggttca agtgattctc ctgcctcagc ctcccgagta gctaggacta  53521 caggcaccca ccaccaagcc cggctaattt ttgtattttt agtactgacg gggtttcacc  53581 atattggcca ggcbggtctt gaactcctga cctcaggtga tctgcccgcc tcggcctccc  53641 aaagtgctgg gattacacgt gtgagccact gtgcctggcc tgataaggtt taaagattaa  53701 ataccatgtc gttaaatttg caaatctctc gaataggaaa atcaggaaca atgacaacat  53761 tcggagcttc ccagaaggta acaactatgg ggagttttgt gggcatctga gagaagcaca  53821 cacacagatg gtttgccttt cattggtcca ttcttgccca gaaggcgaca ctaactgaaa  53881 caaagaagcc tcatatgaga aggacatggg gtcacagcag cttttggggt ggccctgggt  53941 ccttgatctg gtctttctct ggctcatttt gtattgctca ctttgttact tcacaatcca  54001 gggcttgtga catttttctt ctctggagtg gaaatgacag agctgcagaa cacaagtttc  54061 tgattggttc ctatgagtca ggaaagaggg ccagttgaaa ctgggctcac acacacacac  54121 acacacaaac taggctcaca tgtgttttcc catcagctaa acaagttttc agaagtacag  54181 aaataactcg ttggggaagg ggacccagga caatgacaat gtttttgatg gtaatgtctg  54241 cagaagtaag gcaggtttcc tctgtgcctg aaaagatggc accatttgag gagatggcat  54301 actcgtggtg gaatcttcat taagatgtca aactaagctg taggaaatca actctagaaa  54361 acagctctaa tgtgagaaaa catatatcca gttttataga gcaagagctg tgatcatggt  54421 gacatttaac aactgtatta gttggccaag agggtaaaaa tatacttgac ctcttagagc  54481 accataaata ctctcagctt gtgggccaac tgtgtcatgg tcttttttct agcccctcct  54541 ctttctccct tccttcttgt ctctctcctc ctctctcttc cctccccttt ctcctttctg  54601 accctctttt ctcttctcta tcttctcgaa ccttcccttc ctcctctcct ttaggtgctc  54661 agcacctctt tgattcaata aacatttacg gagctccttc ttgtgccaac gactgtacac  54721 agagcbggga tgtcaagatg aatcagttac atttcctgcc caatgccaag ggatggcttg  54781 atgggttttg accagcccct ccctggactc ccaatttctt tttttttttt ttcttttttt  54841 tttttagacg gagtcttgct ctgttgccag gctggagtgc agtggcacga tctcggctca  54901 ctgcagtctc tgtctccctc ccaacttcaa gcgattctcc tgctcagcct ctcgagtatc  54961 tgggattgca ggcatgcgcc accacaccca gctaattttt ttgtattttt agtagagaca  55021 gggtttcacc atgttggcca gggtggtctg gatctcctga cctcgtgatc cacccgcctt  55081 ggcttcccaa agtgctggga atacagtcat gagccaccgc gcccggtgcc ctggactccc  55141 aatttctacc tcctggaacg tgctttactc accagccttg gtgttattct gcaatatggc  55201 caactgggat ttttttcaat cttacagaaa ttattctcgg aaatgtttgc tatttttttt  55261 taatgaagct acagcataca atttaaggat aaataatgta cttactctgc agctattgtt  55321 tcaagtcaaa tccgctgatt actcctccaa aattcttttc ttaataaaat ctctgaccct  55381 ttcctcttcc tgttagaact tctggagcta ccattgttcc tcctcttggg ctgctcataa  55441 cctaggggag tcacagtgaa attacttgct ttaaaattct ttaatcactc tgcgagttgt  55501 taggaaaagc tgacacatct gatttggaaa ctcccactcc agtggactgt tgtgcctcag  55561 cacacaggga cgggtggagc aaaggaacaa gaagccaaaa actctcaggg cacttactat  55621 gattgtgtaa aagagagact catcaattaa cacaggtact ggcaagtgca cttcataatg  55681 cctccatttc tagacagatc aaaaacagtg tgccctgtca ataaatgctg agtttctgta  55741 gcagcctgat tgagatcagc taacctttag gccaaaagcg ggattcttcc ttgctgaagc  55801 ttttggcaaa gcatattgag cttcatgcca gggattagat taactcttgc aaaactggtt  55861 caccaggaac aatgactcag tgtttttttt ttagtatccg gcatattgtg tggagcagct  55921 ataaatatat ttacaagctg gagtttcaag ggaggggagt aatagcttgc tgaaaaacat  55981 gccaactgag ttatgggtct tcacgcagcc agcatgctgt gttttgggct ctgcctcttg  56041 taatttttag aaattaatta gtttattctt tatttatatt tatttattta tttattttca  56101 gatgggatct tactctgttg cccaggctgg agtgcagtgg tgcgatctcg gctctctgca  56161 acctccgcct cccaggttca agtgattctc ctgcctcggc ctcctgagta gctgggattt  56221 caggtatgcc tcaccatgcc tggctgattt ttgtattttt agtagaggca gggtttcacc  56281 atgttggtca ggctggactt gaactcctga cctcaagtga tccacctaag ggtactggga  56341 ttacaggcat gaaccactgc acccggcctg ttggttgtaa ttttattttc ctcctcaagg  56401 actttgagca cattatcttc tctttaataa cttgtttcca ccctcctttg tgcacgcgcg  56461 cacgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatttt ctgatctccc  56521 tacgggggca gagagtctca agcaggtatg tccatgttat taacatactg tctgcttatt  56581 aactaactgc accaatgatg aaagccaact gacaaacaag tgatgctctt atccctcctt  56641 cgcaagcaat gaatctgaaa gccaagagaa gttttccttt caacaggaag tgttttggag  56701 tccgaacaac tctgcattta gacagtgcag cttttagtta cagatcttgg caatggggca  56761 ggcagaggga gcggcaacta cagactttgc cgtaggactg ttttctatgg agtgtgtgtg  56821 ctctgacgag ctagtgacag gagggaggtt acaaaagcat ttactgaaat aaggatttct  56881 aatagaggag ctttttaaaa gtattaaata tgctaatgtg cctagggcat agtcaacaaa  56941 gagttataat acatgtcatt tttcatattt atcaaggaaa ccatgtcacc cgcagccttt  57001 ctcaatttct ggcattctga gaaacacact gtagtggtgc ctgagggtct ggggaaagaa  57061 gaatagaatg aatggggcat ctcagaatcg taaactcccc cagttgtagt tcctttcgat  57121 gttggtcgtt ggatgaattt ccagtttcta ctattgtggt tggattgggg agagtagctc  57181 aaattgggaa ttgctttttg aggatctagg gcttctggaa ttctcccagt ttctttttac  57241 ctctttatgc tatcttgtct actttgaaaa atcagtagca tccatttgat tgcagagctg  57301 aatctttcta tacagtgagg agttgtaatc acattactta taacctgctt atttaacttt  57361 ttaaaggtgc aagtcattgt aacctaagta tttactcaca ctgatcctta atatactccc  57421 ctttcttatc tgcaagcttc tttctctggt ttctcctaac tctgttactg ctcatgagtt  57481 taaaactttg tcttctcagt tcctggcttc acctgtttgg tctctgctct ccaggactct  57541 gccttggaaa tctgactcac acttctatat gtccctgggg ctcaacttcg ggcctggcgc  57601 cagaatcacc caggctccaa gcaagccttg tagactccac tcagtccttt gactcaagga  57661 aatctccact tctaaatggc tctccggttg attctgatgc cagtccaggg ttgagaacca  57721 ccgctttagc ttctagacac acagccccct cccctttttc ctggagcccc tcttgggtca  57781 tgattctatt ttccctattt ctgtactcag aagggataaa aatggaagtg tatgtgaagt  57841 tgctactacg tcccaggtgc tttaaatatg ttattttatt caatcttcac aacagtctta  57901 tgcagtctct atttttattt taagaatgag gaaaacaata cttgggtgca gtggcttatg  57961 tttgtaatcc cagcactttg ggaggccaag gtgggtagat cacttgagcc caggagttca  58021 agaccagcct gggcaacatg gcataaccct gtctctacca acaatacgaa aattagccag  58081 tctcataacc tggtctataa ataaataaat agataaaaat ttaaaaataa aataatttaa  58141 aaagaaaaga atgaggaaaa caagattcag agagccttgg tcatcttccc aaaggtgcac  58201 aattaagaaa tggctaagca ggggttctga ctcagatctg tcagcatcta cagctttgct  58261 atttaaaaga gcgtggtccg tggactagca gaatcagtgt cacctgggat cttggtagaa  58321 acacaaatac ttgagtgcca tctcagacgt actgaatcag tttcttcagg ggtagggtcc  58381 aggaatatgc attttatgaa ggcctctaaa tgtttctcaa agtttaagaa gcatggggaa  58441 ctatatcttt tcctactata tagtcttatc tctttccttg tttctttact ccaaagtatt  58501 gccttatttc tttcccagaa acctcactat cagctcactg tgcagcctta ctcatatctt  58561 cctcaaccag cagttttatt acacacaccc ttctcatttc ctcacattgc tcatggtatc  58621 tgactgagta cagggatcca acctggcttt gggttttgca ctgtcttgcc tcagtctctt  58681 aatttcttcc tatgtacatt ttaagatatt gaagacacta acttccaaac ctcttctcta  58741 aatctgacag tgaagcagtg tgtgtgtgtg tgtgtgtgtg tgcatgccag tgcatacacc  58801 acacatacaa gcacatacac agagttaagt ttggtcacat ttacttcatt aattgatata  58861 taccacaact gagaaaaact tactggcatt ctgctccaag cttgaattcc cagacgaaaa  58921 acaaacaagc aaacaaacaa ctcctcctta cacaaaaata tctagtggcc ttggaaaatt  58981 ccatttaaca ttaaattgtg tctcttcaaa gtgaagcagg gtgggcagat ttttgaacat  59041 gaatctactg ataacacaac acctcttcaa aactagaatc tcattcaggg ttaaatgatg  59101 tccaagtcaa acctgagatg ctagcatgat gccccatcct cagtcagagg tttcagggtg  59161 gcaaacaact tttgctcact ctcctctgcc tctctctata tttgcagaaa gtccagcttt  59221 cactgcaaaa gttcgataac tctgtaaaac agtttgatcc taacttcaaa agaattttta  59281 tgctatttgg aatacataaa aaatgaattt attccaatac tttagcccca taaataatgc  59341 ataatgattg gtgaaagatt agcattttgg agttcaagta cttaaagctt tcttggatgg  59401 ataatgcatc acccttaact agcataaggg gaaatagaag gttgacaagg aaaacttaat  59461 ttagggttct ttatttattt ttctctagtt atgtttacct tcccaggttg ttttattaat  59521 gccacttttc acaaggatat ttcatgaata aatatcaggt tgtatctctg gccatctgtg  59581 atgatcacgt ttttattttt aatgagttgc tcatggatta tatcctaact ggaattgcag  59641 tcagtatatt gagatgcatt gactccattt ctgtctttca ttcttctttc tcaatgtatt  59701 ctcactggat tagcactctt agccctgagg actcttgggc cagttttatt actaaaagaa  59761 gaattacagt tttgctacac agtgaccttg caagaagtat cagcacagct caatttcaaa  59821 ttctcctcaa atatcaaata tgttcttggt atattttgct tagcagttta ttgccttctc  59881 atctccactg tttttcctga gtaacagctc agaaatctat aaataaaact taataatggg  59941 gagtgactca aaagtctggt tatttttatt agtaaactat tttaggggtg aacacttcac  60001 attttacatt ctcatgctcc acagtgctga aaatagtctg aatttttttt gtgtgttagg  60061 ttgatgagaa tatttttgag atgactagca gaaaacagaa tcattaaaac agtgctatca  60121 gttttcatgt tgaataactt tacaggaaat gatagcatct ttttttcttt ttttgagacg  60181 gagtttcgct cttgttgctc aggatgaagt gcaatggcgc gatctcggct caccgcaacc  60241 tccgcctcct gggttcaagc gattcttctg cttcagcctc ccgagtagct gggattacag  60301 gcatgcgcca ccatgcctgg ctaattttgt acttttagtg gagatggggt ttctccatct  60361 tggtcaggct ggtctctaat tcccgacctc aggtgatcca cccgcctcag tctcccaaag  60421 tgctgggatt acaggcgtga gccactgtgc tcagccgata gcatcttaac aataaacatg  60481 caaagatttg taaatgttgg caaacagcaa gaaaaacata tttagaaaat tgtgctatgc  60541 tttaatgtcc tgtctgtacg ataatttact tagctcccta ccttcccccc agcccaccag  60601 aatgtttaaa ctgaaattta aagcacagtt gatcttggct tggataggca gcctgcatat  60661 taactgagga tttagttagt atccaggagc agatctactt ctcaaagtga gattcacata  60721 gcccccttgg aagctttcaa atagattgac tagcctttta aaattcctct tctccccttt  60781 cttattgccc ccgccttgtc tagctgtatg ctaacttgct gcatagaatc ctgaatttct  60841 ggatttctac atttctagct caatgaatgg ggtaaatcaa aacttaataa cactcttgat  60901 tttgaaaagc ttcagtgctt catgtaagac tttttgagaa aagatcattt tcatttattt  60961 ctgttttatt tctagcttaa tgattaaatg taagcbgttc aatacctttt tcaatatccc  61021 acttgttaaa cccacactaa acctcagaaa tattgagtca gtgatctaaa tttccattca  61081 aaatttccac aaagcagaag cataaatgtt ttcattgtca ttacaaataa acagacaggg  61141 ctgggcgcag tggttcatgc ctgtaatccc agcagtttgg gaagctgagg taggcggatc  61201 acttgaggtc aggagtttga gaccagcctg gccaacatgg tgaaacactg tctctactaa  61261 aaatacaaaa aaattagctg gattggtggt gtgtgcctgt gatcccagct actcaggagg  61321 ctgaggtagg agaatcactt gaacctggga ggcggaggtt gcaatgagct gagattgtgc  61381 cactgcactc cagcctgggt gacagagtga gacttcatct caaaaaacaa aaacaaaaac  61441 aaaaacaacc ccttcccctc cacgaaagaa aaccccaaat aaacagacaa atgaaagcaa  61501 tgaaaacagg aaaataattt tgacacctac ttctgggatg ttatgttatg ctttgcattg  61561 gttctattta ttagacatgt tcccatcttt attatttaag agcagataaa ataacctcac  61621 tacattaatc tcttttgctc tgcctctttc catatgattc ttcactagca gttcccaaaa  61681 caaaaaaatt gtgcaccaaa atcccaactg agactcaatt gtttgctgac tcaacaactc  61741 taatgagaaa tcttatacaa gagcttttgt ttcaaaagga agtgccagga aaattttgct  61801 tccctcaagc aatggcatgt tttctttttc tggacagtga gaaccatgta attaaacata  61861 ttttcctttg tgctttggct gtcaggaaac tcagagccaa acttgtagcc caagttttat  61921 ggctatgtaa gacattatgg cccatatatc tggactcttc ctttctcctt ggtattgatc  61981 ttcagtcttg gctttagttt acaaaatatg ccattataaa aaataacagt atctgtaggc  62041 tgtctgaaat tattatggaa aaagtagtgt acaaataaat gaataagtca attgtttgaa  62101 aaacaatgca tttgtatcag aaataacttt gtgagtggtc ttcaggttcc tagtctattt  62161 cattttgata tatatttctt gtgggtttac cacgtgccag acaaagatgt tcctggcagg  62221 ggggttaata atgttaacag tactcagtct ttctagtgcc ttacaggcta tagaaggaga  62281 aagaaataca aaacaaacta aaataggtat tcaattgcaa caaaagcaac ttgatgtagg  62341 ggtacagggg aaggaataat tcattctaca ggcctttaaa agataaagag gtatttcaaa  62401 ggcaaacaat ggagagaaga tcattctaag ctaaggaggt tgcatgaaga aagcataatg  62461 tcactacttt tttttttttt tttgagacag ggtctggctc tgttacccag gctgtagtgc  62521 agtgatgaga tcacaggtca ctgcaacctc caccttcagg gctcaaacca tccttccaca  62581 tcaacctccc aagtagctgg gactacagct gcatgccacc atacccagat aatttctttt  62641 attttttgtg gaaacagggt tttgccatgt tgctcaggct ggtcttgaac tcctgagctc  62701 aagtgatctg cccaccttgg cctcccaagg tgttgagatt acaggcatga gccaccgcac  62761 ccagcataat gtcatcaaat tgaagtgaga aatgggaatg tcactaccaa ccataagtaa  62821 taaacaatag attatcatta actttgctcc tagagaaaga caagtttatt tagaggtgag  62881 gcgagtagaa tttttttaag ggaacttctg ggtaatttaa caccatgatc cttctcgaat  62941 gccttacaac gtaaaaatgt agttctcctt tttcttttct tttctttttt tttttttttt  63001 ttgagacagg gtctcgcttc gttgcccagg ctggagtgca gtgacacaat cttggctcac  63061 tgcatcctcc gccgcctggg ttcaagtgat tctcctacgt cagcctcctg agtagctggg  63121 attacaggcg tgcactacca cgcctggcta atttttgaat ttttagtaga gatgaggttt  63181 tgccatgttg gccaggctgg tcttaaactc ctgacctcaa gtgatctgca cacctcgacc  63241 tcccaaagtg ctgggattac aggtgtaagc caccatgcct ggccattttt cttgataaag  63301 gggtgtcatt ggggcttctc ttactcctgt cactcatcat gggtgccatg tctttttttt  63361 ttttttttga gatggagtct tgctctgtcg cccaggctgg agtgcagtgg cgcgatcttg  63421 gctcactgca agctccacct cctgggttca cgccattctc cggccgcagc ctcctgagta  63481 gcbgggacca caggtgcctg ccaccacgcc ctgctaattt tttgtacttt tagtagagac  63541 ggggtttcag cgtgttagcc aggatggtct caatctcctg acctcgtgat ctgcccgcct  63601 cagcctccca aagtgctggg attacaggcg ggagccactg cgcctggcct gggtgccatg  63661 tcttaattga caaccacaat gaagagagga aggaaagagg aaagaataag acaatacaag  63721 aagaaaaggg aaggaaaagc caatgacaga cattaactgg attttcccac aaagagaggt  63781 catgaggatc aagagcatac agaagtttgc aaaataaaga gtttctctgg cttggagttg  63841 accaaaataa gagaaaggtg aagcgagtat aatgtacgga gacttctcct gggagaagtt  63901 gtcagtggag aagttattgg gtcatatagt gatggtgtgc agataggacc tggtggtgag  63961 ttgacgagga gccattgcca ttcagccatc aagaatcatg atgtgtgttg tgtaggaatg  64021 gagaggtgag tgtggagtgg atggggcgta gatggagaag caggaggatt cgtcatgcac  64081 cctgaggctt gccagtattg atgtcagact tcctccgacc gtgttgccac cctggactgt  64141 ttgactttgg tagctatttt aaaacagcaa gaagagctgc ttgagaagaa cctgggggag  64201 atttcacaac cagcagctgc atcgaatctc cctggatgtg tgcttttgga aacaatttac  64261 acaagggctg atttcaacat gcactaatat atacagttta gctggcattt tatatggaaa  64321 ctttaataaa atggttctaa ttagtgctta atttacatag attagagagt tctacaggcc  64381 cacacagtag ggcttgggga ttttatgtca tttgatggag atgccagttt gattcagata  64441 aagaaccaat tttagggaat actgctgaag tttgcccgac acaaatgaag gagttgtagc  64501 ttgcatttct tttacccact cttgttcagt ggcttgaact agctttctgt ctcttccaca  64561 agatttagga caagatggat ttctgtgtca gcatgtagta ggagagcttt gattttctag  64621 ttctgtcctg tgtggatctg tatgtagctc agattccccc acaatctagg tcagagaagc  64681 tgctagcctt ggtgcaaagt tttcaaaaag gcttctattc agagagatga ataaggaaaa  64741 actcacaccc tacgtgcgaa ggttgcttaa tgagaggtgt gagatggagc tcagttgcca  64801 cttatctctg tagttgggta ccgttgtgca gtctgtgcac tgcccagcca tttgcagtga  64861 ccccaaagag gatcatctgg tcatcttgcg gggagagact gtgagttcct gccatgtcac  64921 ttggtataac atgagaaaac tcaaaactct aggcagatct ttgcacctgc cctacttttc  64981 tacctgctct cacaatcttc ttgagggtga ccagagtcca agtaactaag tgtaattcaa  65041 tgtggtgaat gatatgattg ctacacagga gtatctatta aggctttcaa aatgtaaaga  65101 ggaagtgact cattcttcct ggtggtggtg gttgcatcaa ttggtgtagt ctattgcctc  65161 tctcccatca acaagggaca tttggcaaag tctggagtgt gtcaactgtg gggtggtggt  65221 actaccggca tctagtggat agaggtcagg gatgctgctg aacattttac aatgcccagg  65281 acagccctcc cacaataaat tatctggccc aaaatatcag tagtgctgcc attgagaaat  65341 ctggttatgt aacagataac tttttttttt tttttgacat ggagtttcac tcttgttgcc  65401 caggctggag tgcaatggct tgatctcgac tcactgcaac ctctgcctcc tgggttcaag  65461 tgattctcct gcctcagcct cctgagtagc tgggattaca ggcatgcgcc accacgccca  65521 gctaattttg tatttttaat agagacgagg ttttaccatg ttggccgggc tggtcttgaa  65581 ctcctgacct cagatgatcc acccacctcg gtctcccaaa gtgctgggat tacaggcatg  65641 agccactgtg cccagccaac agataacttt ttaaattctc agcbgtttaa cccaacaaat  65701 aattattttc ttcctcaagc tgtatgtcca gcatgggttg gcaacatagc cctgtttttc  65761 ctagtccctt caagaagtct attgatggaa gatgcatttt tatgtgggct tctaccacca  65821 ctatgagagg gggaaggaaa tttgttggat tgtaccctga attttaaaaa gcttctgccc  65881 agaattgaca tatattcttt ccaattgcat tttattggcc acaatccatc atatgaccat  65941 gcctgaattc agagggagta ggtggagaat acatttttaa tttttaattt tttttttttt  66001 tttgagacag agcctcactg tcttgcccag gctggagtgc agtggcgcca tctcggctca  66061 ctgcaacctt tgcttcccag gtttaagtga ttctcctgcc tcagcctcac aaatagccgg  66121 aattacaggc atgcaccccc atgcctggct aaggtttttc atatttttag tagaaatggg  66181 gtgtcaccat gttggccagg ctggtctcaa actcctggcc tcaagtgacc catcctcctc  66241 agccttccaa agtgctggga ttacaggtgt gagccattgt gcccagagag agtgcatttt  66301 tgtcttgtac ccagaaagag gagagagtga gaataatcat gaactaccct aatgactatc  66361 atgctgatgg taatggtggt tgtaggatgg tgtgagaatt taaagacggc ttcactcctg  66421 tcactttgct tacttactgc tgtataacaa actgccccaa acttcaggga tgaagctaac  66481 aaaaaaatca tttaatttgc tcatgaagtt gcaatttgga tagggctgtg tagaacagct  66541 cctctctata ccatggggca tcagttagga cagctcaaaa cctgggagta actcaaaggc  66601 tgggggctat aatcatctga atgcttgctc actcctgtgc tctcatgtca ggcagtggat  66661 gctggctgta gacagagacc tcagcbgtgg ctgtcagctt gaccacctac tcccagcctc  66721 tacatgtggc tgtttggctc ccttacagta tggtggctgg gttccaaggc agaaagtaaa  66781 tgctgccagt ttcttaaagt ctgtctgcaa attggcacag cattctttct accatattct  66841 attcatcaag gagttgtaga ggccaatttt aaggggaaga aaaatagacc ctatgtttca  66901 atagcaggaa ggtcaaagaa tgtggaggcc ccagaaaact gcttcccagg taagtgacag  66961 gatagaaaaa caagattttt tttttttttt ttgagacagg gttttgctct tgttgcccag  67021 gctggagtgc aatggcgtga tctcggctca ccacgacctc tgcctcctgg gttcaagtga  67081 ttctcctgcc tcagcctccc gagtagctgg gattacaggc atgcgccacc cagttaattt  67141 tgtactttta gtagagacag ggtttctcca tgttggtcag gcbggtcttg aactcccaac  67201 ctcaggtgat ccgcctgcct tggcttccca aagtgctggg attacaggtg tgagccacca  67261 tgccaggcca gaaaaacaag acttctttag gtggagtttg gggaatgagc tttctggaca  67321 agtaaacggc atgcatcaag gcacagaaac atcagagctg catttgaata aattctccta  67381 gctggtctta cctcctagct acttacttct actgttgaca tcaaccttat aaacttgcta  67441 gaggctcagt gtggggaaac aaacaaacaa agcctcatga aacgttttga tccaattaga  67501 aaatgtctat taaatacatt gtgtttcaca aatgtgaact attaatacaa tctgggtttg  67561 ttccgattta attgtctaaa attatacata attcatcttg ccaacaaatg aaattattga  67621 aaaattaaaa atatcaccac caattttttc tattaaatgt atatttttgt aatgatagct  67681 taagtttcat ctcagtttga gatttagtac actgtggcat tcactctggt tggggttcat  67741 ttggctctga gcttcaaggt tcaatttaga cttcaaagca tgtcggactt gacctgaggc  67801 acgtttttaa caatcaggtg cagtttgtaa ggttatgggt tgaggaatag cataaatggg  67861 ccatcctttt tctgattttg agaagagaat gactactaat acccaggtgt gttcttgtct  67921 ttcttgagtc aattctaaca gcattggctg tgggttataa aaccataaaa ttttacagcc  67981 aaaaacaact ttaaaggtcg tttagatgga acttcttcat tttgcagatg aggaaactga  68041 gaatcagaga caaagtgacc tcagggcatt acaacttact attactatat tgaaagagga  68101 agggaagctg gtgcaagttg agggacccac tgatgaactg cagggtatcc aatgttgccc  68161 ctgtgtttgg gctgagggag aagcagcttc ttagcttctg ctatgctgac ttatcttgtg  68221 atctctgtcc cagcccttgg ctgcctctcc tccttgtccc caggcctgca ccattccatc  68281 tgcctcctga ttattcactg acagctgcct tttccctcac cctttgttct cagtttttaa  68341 aaatccaatg gggagaagct tggattcaaa tgatagcatt ttcagctcat gaaaaattct  68401 ataacaagtg tatttgaccg tttgatctct ggcttctccc acacacttgc cctttatact  68461 ctgacagcca taagcttcat ttccttgaag cagattgcaa tttcaatgga aaggaaataa  68521 ttgtgtagct ttcaagctga gttcagttct aaaaaggact gagcaaagct caatcctggg  68581 ctattgtaga atcttagtca ctgaatcagg cagtgaaaga gctctctcca agcttcatgg  68641 ttatgatctt gaaaaacacc agagctaggt tcaaattcca gccataccat ttcctaactg  68701 tgtgattttg gcaaatcaca caaatactta aaattctttc gactcggttt cctcttctgt  68761 aaaatgggaa cactaattaa tgctcacctc aaaaggttgt tcattcattc aacacatatt  68821 cgttgggtgc ctcctgtgtg tcaaactgtt tcagtccagt gaggaagatg gacatgaatc  68881 caagagtcac caaaaaaatg taaagtggca cctgtgatga gtcacaaagg ggaggtatat  68941 gagaaagtgt gtgacagtat ctaacaggtg agggcattat ataatttatt gttgcaaaca  69001 ggacattttt gagcatgtaa gagggtgtgt taattgtcct ggaacaacag gcataaatca  69061 ggactttctg ggcaaactca ggccctaccc cactcttacc tacccttagt ataagaggga  69121 aggttgggaa aggctttcct ggggaaggga agaagaaact gagatccgcg gaataagtga  69181 ggattcctag gcaaaaagag gaagacagag tggtttaggc caagagagca aacagtggtg  69241 caagactcta aggcaggaca aagcatggag cctgcagaga acagacagaa ggtcagtgtg  69301 atgaagatgg gaggggtgcg tggctttaaa cacaggcccc ttgcttgttg gtttgccctg  69361 taggtgttaa gaaatgaggc tatatcaagg tgaattttaa gtagaggtgg cacctctact  69421 taagaccaga cttgcagctt taaacatcag tctggctgca aggcagaatg gattagcatt  69481 gagtagtagt tctggccttg gctttccaga ggaaacttct aaacaatatc aaagccttgg  69541 tgtcacccac agagatcctg atttaattag tttaggttgg ctcccagtag gttataaagt  69601 gtgtcaggat tgagattcac tgtagaagga agtgtgaata tggagaagaa taattacaag  69661 gctattgcag tagcccgggt aagaagtgat ggaataggtt catggcagtg ggtttctgaa  69721 gcagtggttc tcaaactgta gtggatttga gtatcacctg gaagtcttat ttatttatta  69781 gagatggtct cacactgttg cgtaggctag agtgcagtgg tataatcata gctcactgca  69841 accttgatca gccttcatct cctaggctca agcaatcctg ccacttcagc ttcctgagta  69901 gcbgggacta caggcatgga ccaccatggc tatttgtttg tttgttttta atagagacag  69961 ggtctcactc tgttgcccag gcbggtctca aattcctggg ctaaagcaag cctctctcct  70021 tggcctccca aagtgctggg attatagcca ctgcaccttg gcacggaaac cttgttaaaa  70081 tgcagatatc tgggtatcat tgatttagta ggtcgtggat ggggcctgag aatttgcatt  70141 tctgacaaat tacctggagg cgctagttgc tagtttagag atcacactta gcatctagtg  70201 ggtagtggtc agggatgctg gtgaatatca tacaatacac agaacagccc ttttgctgat  70261 cactgatcga gcaaaaaaac catctgatgt ggtagataac atcaacagga tttgatcagc  70321 agggtaaagg acaactccag gactcttaca gttttctgaa tttcacaact aaatgacgag  70381 tttcactatt cattgacatt caggagacag ccctacagac ctgagaagat ggtgaagtca  70441 aagctacaca tatatttgag ggttaccttt gaaacagcta agaggataca tcaagcagga  70501 acatatatgt ggaacctgga agggaagatc attacagata taaacttggg gatcattaaa  70561 gccaggaact tatcaatggc atcagtcagt tctcttttct tttactctta tcattggtgt  70621 caaagctctg gcctcttttt gttggttcca ctcaggtgcc gtgatcctcc agcctcagca  70681 ccttgcbgtg agctctcctt gggaggctgc ctctccctcc tccttcagaa tttaccccct  70741 acttctcctt tgggtcccac ctctcaggct tggtcatgtg tggcattagc aagcaggtgt  70801 gcgtgtttcc ttctgaagca caaatcaaag ccatggttat gtatctgtgg gattatttgc  70861 taaatggcca cctctcctgc tagattctaa gttgcctgca gtgactggag aacatcccta  70921 ggtatcagat gctcaatgtc ttacacttat ggaaccgtca aagacagctg ttaaatgtcc  70981 aatgggtcag ttagggagat ggtggttgtt aaaactgtga tgagttctca ggaagaggga  71041 gaagcagtta cctttgtgaa gcagttgttg gtatttactt agtaatgaga ttaaatttcc  71101 taggacagtg ggtgtgtgaa ccagcaatag cgccatctgc tggaagtaag tgatacaaca  71161 actattatct tgactaggct cagggcbgtt aaaacagtat tgctctggga gaaaagaatc  71221 atttttttta aggttaaaaa tgtgagtaaa attctttaga gtgaagatag aatttctttt  71281 gaaatggttg gaaaaattgg ataattattg aaaatagtgt tcagttttca aagaggagag  71341 aaaccttcaa gtcactgtaa ttaagagaag ttttattgaa agaacacatg gaataaggaa  71401 gttagatatc tccacccaaa accagcattt cagaaaacag aaacaggcaa aaatctggcg  71461 gagtgtggtg gctcatgcct gcaatcccag ccctttggga ggccatggtg gaaggatcgc  71521 ttgaagccag gagtttaaga atagcctggg caacatagta agatccccat tttctttttt  71581 cttttctttt cttttctttt tttcttttct tttctgagac agagtgttgc tccttttgcc  71641 caggctggag cgcaatggca tgatctcagc tcaccacaac ctcccgggtt caagaaattc  71701 tcctgccttg gcctcctgag tagcbgggat tacaggcatg caccaccaca cctggctaat  71761 ttcgtatttt tagtagagac gtggtttctc catgttggtc aggctggtct tgaacgcccg  71821 atctcaggtg atctgcccac ctcggcctcc caaagtgctg ggattacagg catgagcccc  71881 cgtgcccagc cccaagaccc ccatttctat tttaaaaaaa aaaaagaaga agaagaagga  71941 aaagaaaaga aaaatggaaa caggcgaaaa cctaggcttc tcaaagactg aagggtattt  72001 tggaactgac tggatattgc tcatctctgg ctggttgtgt tgcagcctcg ttggtggcaa  72061 gtgcagaccc tcagtcagtg acctcctttg ttgctcttcc atcaaagggc ccccttctcc  72121 tgcccaggca tggtgttact aatatggcga tggtaggggc aggggctgca tctatgacgg  72181 ggagaggtat gagagtatac tcatcattct gctgttgtct ttgttagttt gtttctaatt  72241 tctattgttg gggagaaaga taaattcttc cctaacctct tgggatcttc acctgggtct  72301 aagaattaaa tcactgtaag acaggttaac aggagaaaaa tatatgagtt ttattgattt  72361 ttacatgtac gcggagaccc tcatgagaca gcagaagacc tgaagaaatg gacaaagcag  72421 aaagctctaa taccttttag acagagaaac cataaattca tgaagagctg acaagacaaa  72481 ggggtttggg ccagtggcag taaattgtgg gaattcacta gggaggtgta aagatagagg  72541 aagataaggg atagtttaga aagtttattt gtacagctcc attgcagcat caactcccag  72601 tcaatggtga taagagttat tttcttattc tggtacaggg agggcaactt tcttaaataa  72661 atctttttgg cttacgacag gtagaagagg gcagatcaca tagccctttc cggcatctgc  72721 tgtttctcag gtgactttag ctcaaaataa tcaacatgcc acatcagcaa attttggggt  72781 gacatggcct gtttcgctat gataatggga aagaaatcag actttttaac tttgaattag  72841 aaaacacaaa ctttgactat gtcccacaat ttatgtgact gatttcatat tctatcacat  72901 ctattttata ttctctcata ttctcctcat gaattttccc ctagaatgtt gggggaattt  72961 tgaaatgact tggggggcat gctacaattc gaaaaggaga gagacatact ctccaattct  73021 ctccctgcct gcctcacaat gtgcagctct cctctgcttc ttcttcttct tttttttttt  73081 tttgagacag cgtctcactc tgtcacccag gcttgagtgc agtggcgcaa tcttggctca  73141 ctgcaagctc cgcctcccag gttcaagtga ttcttctgcc tcagccttcc gagtaggtgg  73201 tactagaggt gtgtgccacc acgcccagct aatttttgta tttttagtag agacggggtt  73261 tctttatgtt gaccaggcta gtctcgaact cctgacctca ggtgatctgc ccacctcagc  73321 ctcccaaaat gctggaatta caggtgtgag ccaacatgcc tggcctcctc tgcttctgat  73381 tcaactgctg ctaccgatag acttactgaa ggatttgaag ccaaatggta ttaattttgg  73441 tcagttactt ccctgtatct ggtgtcctca ctagacagaa cttctgtgta tggctacttc  73501 atagaccccg accagcctac atattgtttg ctctaaggtc tagtgccctc tcttatttca  73561 ctaagataca gccactgttg gtgggggagt cacataacat ggaacataat cactgtatca  73621 gttcaggtgc tcttgattca agtggattta attatgaggg aatttattcc ttacataatt  73681 actaagtcta gcattagagt ggcctgcaga tgagggttga tccagtggct cagtgatggc  73741 cagaacgctg tttacttttt ccattctgct atctatgggg ttggcttcat cctgaggttg  73801 ttttcctttc tgtcacaggt tttacatcaa tggggtaaac tagtttacat tgtggtaaca  73861 agcaactctc aacttttttt tttttttttt tttttagact gaatcttgct ctgttgccca  73921 ggctggagtg cagtggtaca gtcttggctc actgcaactt ccgcctcctg ggctcaagtg  73981 attctcctgc ttgagcttcc tgagtagctg ggattacagg catgcaccac cacgctggct  74041 aattttcgta tttttagtag agatggggtt tctttttttt ttttttttct ttttgagaca  74101 gaatcttgct ctgtcgccca ggctggagtg cagtggcgtg atctcggctc actgcaacct  74161 ctgcctcctg ggttcaagcg attcttccgc ctcagcctcc caagtagctg ggactacagg  74221 cgcatgccac cacgcccggc taatttttgt atttttagta aagacagggt ttcaccatat  74281 tgaccaggct ggtcttgaac tcctgacctc gtgatttgcc cgcctcagcc tcccaaagtg  74341 ctgggattac aggcgtgagc caccgcgccc agccaactct caactctagt agcttaagac  74401 aacaaagatt tatttcttgc tcttactgtc tgcccatctg tatcaccttc tctgcaggac  74461 ccagtttaat ggagcacaca cagaaaaagg tgctggtcac tagggccaag ggaacaatgg  74521 ctctggaagg tttttcttga acaattcagt gttccagtct tggagcaata catcttattt  74581 ctactgttaa atccatggcc agaactaatc atgttgtccc actcaccaca aagccatatg  74641 cagccccacc atgtgctcag gaaagaggaa tgggaagcat ttgatgaaca gaaataatga  74701 cttcaacaat tgggactatc agttcacagt ttcaattgta aaaaaaaaaa aaaaaaaaaa  74761 agacagaaat agaaaaagaa caattgaaag tacttgcttt ctcatccacg aaaaaagttg  74821 gtcaaagcct cttagtgtaa gtctatagca gatgatgcct gataaggaat tgtacatacc  74881 gttcttcgtg aaaaccaaga gtaccatgta tgtaacatag ttgctttggg cttcttatag  74941 cagttaagag tgtatcagca ggcctccatg gtatttgaat gttaaaagct ttcattcccc  75001 ctggaagaaa acacatagct aactaaagaa agaaaaaaga agggaaaaag aacaaagaaa  75061 aagaaccact agagtctctg aaaagagctt atgagatacc tgactgtctg cgccttctaa  75121 gtatgtacca tgaaacctta gattcctacc tcattttgtg atggtgtaga aggcacattg  75181 gccaccagca acccttgtaa atatttgcgg atttgaattt cacaaattga aacccagact  75241 gctgagggct ttgctgctaa cgtcaaagag ctggggcaac taccacaaaa ccacatgtgg  75301 gagacttttt agatgaggag ataggaaatt cctaataaga aaagtttttt tgtaaaatac  75361 tttctaatgc tggctcttta gagaagcaca ttttacatgt gcaatggtgc aaagtcctag  75421 cactaagatt tcttcactca cagaaagaaa gaatgatgca ggtgctgttc acatgcggcc  75481 ggaaccatgc ccttgccaag caggtcagcg gggcacaggg actgcgctcc tcatgatagt  75541 gcagattggc tcggaagtac tcaattctgt ggagtcacag cgccctctga cagatttcag  75601 tttctggaaa aggaagggcc cccttcaggg tacctgctgt tcaccttcca ttagattaag  75661 gttgaagagc gagtggccat ttgtaggtac tggtatgaga tgttcctagc tacccgcatg  75721 tcagccccgg gaaacggcaa catttcccac ccttcttacc ctgggtcctg agtaggaata  75781 aaagttagtg attcttaggg gcatattgag agctggcaat gatacctctc acaaatccat  75841 cccccagaga taaggggtcc cccatgcctt tgatgtattt gggagcbgtg ctgtatgtgt  75901 tctctttggc tccccagtgg agaataataa caataacaac cgcgtactaa tacaacccag  75961 atgtcagcac agaccctctg ttctctgtct tccctgagat atctgtatct tctcagggat  76021 tactgtcggt tcaggcctgg ctcctgcttt cagcttgtgg gaaaactcac tccatcttca  76081 ttccataacc tcacatctcc tatgccagtt cccttctctg tgctccatgc tgaaccaaat  76141 gccacactca tcccctttgc tttgaattat atgaaaaaaa gaaaaaaccc tcatggggac  76201 tttatgtgta acagtcttca ctgcacattt gataacacag atgggggttt atatcctagc  76261 agagcagata ttgtcaatgg aaaatggaaa caaaacaaaa cacaaaagac aatcttcagc  76321 catcactatg tagcttggct atcatctttt gctttctcct ttacttctgg agtcccccca  76381 cataccctca gaaatggaga tagactctac atcaatctct gctctgggaa atctactcac  76441 atatccaaag gcaaactaac aagctcttgc tccgacaacc catcgacttg gggtctcatc  76501 cctccctgcc taccagtctc tgtgactgaa aggggcccat acagagactt attttcccag  76561 gaacgtgaat gatatccttc tcctgttcct tgaccttggg aggcagattt gattatggtc  76621 agctttgatt caaagtaagt tttttttttt ttctccctta ggagaatgtt gtgaggtgct  76681 gattgttctc tgcttcataa tcgtatcact tattactgat aatctttttc tgcccccaga  76741 ggttgctgaa gaatgtagca tatacagtgg acacagagcc ctgataatac aattactaaa  76801 ttctccaagg ttgagggcct ggtcttaggt catgagatta ctgatccttg ccttctgcct  76861 gctaggaagg cccaactaat ttcacagtct ttatcagtga accatagtaa agggggacca  76921 gaagagaaaa aggttatgtc ttttgggaaa atgccaaaat catattgtga aaatccttcc  76981 tactgttctt ctcatgggag ggggaggact ttggacttgt ttctctcctt ttcctgtaca  77041 tttggggatg tcagaaccgt ctgtttcctc atctacacgt ggttagatgc cgacaacaat  77101 ctcttctctt aaaattgctt actattagac cagcagagtg tttggtatta attgagcaag  77161 gaggaatttg taggaaaggc ttggcttaac taggagaggg aatgccaggg agaaatctgt  77221 atttcccact attttttttt ctttttttga ggcacagttt cactctgtcg cccaggctgg  77281 agtacagtgg tgcaatctca gctcactgca acctccgcct cctgggttca agcgattctc  77341 atgcctcagt ctcccgagta gcbgggatta caggcgtgtg ccagcacacc cagctaattt  77401 ttgtattatt agtatagatg gggttttatc atgttggcca ggccggtctc aaactcctgg  77461 cctcaggtga tctgcccacc ttggcttccc aaagtgctgg gattacaggc atgaaccacc  77521 acacctggcc atttcccact attttgttga taaagacatt tggatttccc tgcattaggc  77581 agatgtggaa gaagatggaa gcgatgaaaa ccttcttgcc aaaatctccc aaaagacctg  77641 gccagtgggt gagcagatct cagttacaaa aagcctatag gttgaatttt ctaagaaaag  77701 gcctggggag gaggtaccag gagtccaaat tgaagttcga ttttcattat cacagatttt  77761 catatctctc tatctccctt tttttgtttt tggtgagaca gagttcaaga ccagcctggt  77821 caacatggtg aaaccccgtc tttactaaaa atacaaaaaa ttagccagcc gtagaggcgg  77881 gtgcctgtca tcccagctac tcgggaggct gaggcaggaa agtcacttga acccaggaga  77941 tggaggttgc agtgagccga gatcatgcca ttgcactcca gcctgggcga caagagccaa  78001 actccatttc aaaaaaaaaa agaaagaaaa agaaaaaaga aaaaaagaaa atgcactttt  78061 tgcbgtcagt aaaagttaag caaaagtctt gctgagagac tgatatttaa ataactatta  78121 taatgcaatg taaaattact gcaagagata tgaacacagt gctcaggaag cttagaggaa  78181 ggagaaacca agtccttagt gatggaaggt gggctgtcaa ggaaggcttt gtggaggttg  78241 tgtaattgta ggatgagggc catgtagtag gtcgacgggg ccctcgtgtg ccaggtggaa  78301 ggaagccatt taagtctttt aagctgagtg gtggcatgat tacaagtgca ctttagaaaa  78361 atctctatgg cagcaatgtg gaggatgaag taacaaaaat atacactttg gttcattttg  78421 ttctaaatgg caactttacc tttaactgtg tacagagctt actgactata ctcaagcaac  78481 aaaatgcaca cttggaaatc ctgtgtcacg tgcctatact agctttgtcg ctgattcagc  78541 atatacacat cctccagtgt gacaggattg tgtatggaaa caggtaagac tggtgaatac  78601 taggctgtgt tcaagtgtag agtctcatga ttatcaccaa tactgbgggc tctccctctt  78661 ttagatgagt ttttctacca tatctttggc tttacaaaat atattaacac agtttcataa  78721 tagatctctt ggaatatggt cgtttggtgt taagcattct atctggcaaa atgaaaaata  78781 agatggtaag agttatccta caaaaatcct aatgttctca agctactgct gaaattcttt  78841 ttctagtaat ttacaaaaaa gtccccattt tcttgtagaa ataagccaat taaaaaaaga  78901 aaaaaattaa aataaaaaat taaagttctt aatgataaat tatattaaaa tttatttcct  78961 gttttaccct atatcctatg agcgtggttc tcaaacttcg ttcagtgcat accagaatca  79021 tcatgtgcgc ttgttaaaca gaggtctggg ttccaccccc agagcttctg attcacttca  79081 tggaatctga gaactggcat ttctgacaag ttcccagggg atgctgaggc tgctggtcca  79141 gggaccacac actgagaaat attgttctga aataataaca gctaattttt gttaggcagt  79201 ttctgtgttc caaatacagg ttgaatatcc cttatccaaa atgcttgggg caagctgggt  79261 gcagaggctt attcctgtaa tgtcagcact ctgggaggct gaggcaggag gattgcttga  79321 gaccaggaga ttaggaccaa cctaggcaac atagcaagac actgtttcta cacacacaca  79381 cacacacaca cacagacaca cacacacaca cacacacaca aattgccagg catggtggca  79441 tatccctata gtcccagcta cttgggaggc tgagggagga ggatcacttg aaacaaggag  79501 tttgagacta tcctgggcca catagtgaga ccctgtctct acaaaaaata tttgaaaaat  79561 tggccaggtg cggtggctca tgcctatagt cccagcactt tgggaggctg aggcaggtgg  79621 atcatttgaa gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccgtctctac  79681 taaaaacaca aaaattagct gggcagtagt ggtgggcgct tgtaatccca gctactcagg  79741 aggctgaggc cagagaatcg cttgaaccca agaggtggag gttgtagtga gctgagatcg  79801 tgctcctgca ctccagtctg ggtgacagag tgagaccctg tctcgaacaa aacaaaacaa  79861 aacaaaacca aaaaaaccaa aacaaaaaac atattagctt ggcatggtgg tgcattcctg  79921 tagtttcata tgtgatctca ctactgcact ccaatgtggg tcacagagca ggactcaaat  80041 gaaaacaaaa ccaaaaccaa aattcttggg accagaagta tttcagattt cagattattt  80101 tggattttga aatattggca tgtatctaat gagacatctc agggatggga cccaagccta  80161 aacacaaaat tcatttattt ttcatataca ccttgtatac atagcctgaa ggtaatttta  80221 tataatattt taaataattt tgtgcacctg tcacgtgagg tcaggtgtgg aattttctac  80281 tgtggtgtca agtcaatgct caaaaaattg cagattttgg agaatttcag atttcagatg  80341 tttggattaa atgtgcttag cctggacctt acttgttgta gctcgtttaa tcctcatggc  80401 aatgctagga cacaggtggt tttagtataa tattattaca aatgaagagc ctgagacttg  80461 agaaagtaag acaacacact ccaggtcact cagccaatta gtggtgagca agaattgaac  80521 ccagatttga tatgcgaatg acttgctgtg attctcctat tggtgatttt tttttttttt  80581 tttttttttt ttgagacagg gtcttgctct gtcacccagg ctggagtgca gtggcatgat  80641 ctcagctcac tgcagcctct gcctcccagg ttcaagcgat tctcctgcct cagcctcctg  80701 agcaactggg actacaggca tgtgctacca tgcttggcta atttttgtat ttttagtaga  80761 gatggggttt caccatgttg gccatgtgga tctcgagctc ctgacctcaa gtgatccatc  80821 cgcctcggcc tcccaaaatg ttgggattat aggcgtgagc cactgcaccc ggccccttat  80881 tggtgtattt ttatttccca agtatgacac ctgttcagag actttggaac cctgagaaca  80941 ttttgttggt gtgttttgtg actaatattg cctttttctg agatgaatgc tgttctttga  81001 aaaaacattt gtatttttag atagaaatgt acttcatccc cagtgaatat ttctgacttt  81061 agagaaattg ccaaacctgc tgactcataa caaaaataaa gagcatctac tattcagttt  81121 atggctttta gttttgggag gtggtaggag gaaggataga ttaccaccca ctatagatca  81181 ttttattttc attttatttt aatgccattt accagtattg tgtatatgga ggtggtcttg  81241 agagctttgt ggagattatt ttttcaatag tacagatggc tctgataaat atttaaggca  81301 tcttgggaaa caagaatacc atcctgactc aggagaaatt ggtcacgtaa atcactttgt  81361 ttcaagtgct ttggcctctg agcatctcaa atggacacat acttcattgg cttattaact  81421 cattgccgga gtcactgaag gcccaaacta caacttcatg cctgaccaca caccaaggct  81481 tttttattgc ttagttttct ggctctttgc ctattctgct ctccctaccc ataaccatgt  81541 gagtatcatg tccagcaaac taacttactc cttctctctc cccactacac acacacacac  81601 acacacacac acacacacac accacactcc acacgcacac atacacagag catttttcat  81661 gggtatgttg tcagacagat ttctctgttc tgaaggctca tctccttaga gaaccttacc  81721 gtgtcaatgt tgcatttagt ttagtttagt gttgttgttg ttgttgttgt tgttgctgtt  81781 tttaaatctt gctctgttgc ccacagtggc gcgatttcag ctcactgcaa cctctgcctt  81841 ttgggttcaa gcaattctcc tgccgcagcc tgctgagtag ctgggattac aggcccccgc  81901 caccatgtcc agctagtttt tgtattttta gtagagacgg ggtttcacca tgttggctgg  81961 tcaagtcttg acttcctgac ctcgtgatcc acctggcttg gcttcccaaa gtgttgggat  82021 tacaggtgtg agccactgcg accggcbgtt tttttttttt tttttttttt ttttttcttt  82081 tttgagacgg aatttcgctc ttgttgccca ggctggagtg caatggtaca atcttggctc  82141 attgcaactt ctgcctcctg ggttcaagca attctcctgc ttcagcctcc caggtagctg  82201 agattgcagg tgcccaccac catgcctggc taatttttgt attttagtag agatgggatt  82261 tcaccatgtt ggtgttgtat ttagttttaa cactgttatc ttctcagatt gtaatgagag  82321 aacaggctat catcacttgg tgataaaatt tcctgtaatt ataatctcat tctcaaagat  82381 aaaacattga tacctaatgt gcttttaact ttaatgccaa tttatcacaa tggaagacat  82441 ttcaaataaa tactgttttt ttgttcataa ggtcttaaaa atcttgaata taactgcaaa  82501 aaagcattac atgttaaaag aaatcacaaa attagttaag aaaggagcca aactgaaaga  82561 agattatatt tctatgccct tgaatcttta caaaatttag taaaaactat taatatagaa  82621 ttatttacaa gagacttctc tatttaccag cccaatatct tcacatttct acaatctaag  82681 gggaggtgat tgtggccaga aaagtttctg ggctctggta ttgcagtttt cctgcactta  82741 ccaccatccg gcatgttata tattttactt atttttcttg cttattgctg tctctttcca  82801 caagttccat gagcagagac agtttatctg tgttttttac ggctattctc aatgtctgta  82861 acagtgtcta acgtactata gtcattaaag aaatgctggt tgggtgaatt cagaaataaa  82921 ttagtaaata ggtgaagcat gttggtttaa tattcatcat cagaacttaa aaacagttta  82981 aagaacctca actgagtttt gtacaataag tagtgacaag gtgggacaga ggtaatttct  83041 ttgtatctct gaggctttcc atttcatgag gaacatagaa taatatgtgt ttccaaatgc  83101 agtgttcaat atctgaagag tatatatcat cagtatagaa aatagacaac acatgttaaa  83161 gggaatgtaa aaattctaga tgatttttaa ggtatgtatg gtttaatcaa ttgtttatat  83221 gctattctct tctcttaaaa tgaaataatg cgaatgaaaa aataaacctt acaggtagtt  83281 tctgggaaat tcagacaaca aaattgtcta acatacgcca aaaacaatat agcatttaat  83341 gatgacatgg attccgaaag acaaatcact gctcatcata ttacaaggaa tccaaacaac  83401 tgaggggtta tcatttatct atagttgcat aacaaattac cctaaaattt agcagcttaa  83461 aacaacaatt tattatttca taaatttctg gggatgagga atccagaagc agattcactg  83521 ggtggttctg gctcaaagta tcttatttgt ttgctagggc tgcbgtcaca gaacacaaca  83581 gcacaggtgc cttaaataac agaaacatgc attctggagg ccagaagtcc aagaccaagg  83641 tttcctctga ggtctccgtc cttggattgc agatgcttgt cctcttgctc cctcttcaca  83701 tggttgtccc tctgtgcaca tgcacttctg tgtctctttt tgagtgaaaa tttataagca  83761 ttccagtcag attaattttt tttttttttt tttgagatgg agtctcactc tgacacccag  83821 gctggagtgc agtggtgcaa tcttggctca ctgcagcctc cacctccctg gctcaagttc  83881 ttctcctgcc tcagcctccc aagtagctgg gattacaggc atacaccacc acgcctggct  83941 aatttttgta tttttagtag agacgtggtt ttgtcatgtt gcccaggctg gtctcgaact  84001 cctggcctca agttatccac ctgccttgtc ctcccaaaat gttgggatta caggtgtaag  84061 ccattgcacc ctgccccagt cagataaaat tttaatctca ctttaactta atcacttctt  84121 tgaaggccct gtctccaaat atagtcacat gaattagggc caagctgtat ggcttcattt  84181 aaccttaatt acttctttag aggctctatc tgcaaatgcc tccacattct gaggtggtgg  84241 gggggttagg atgtcaacat atgaatttga gggggcacaa tttagcccat agacacctgt  84301 catgaggttg tagtcagctg tcagttgggg ctgcaatctc atctgatgga ttaactgggg  84361 aaagatgggc ttcccagctc actggtgtag ttgttggcag gcctcagttt cttctcgctg  84421 gagacttcag ttcttgccat cggcttctcc acaggttgtc cagattacct aatgacatag  84481 cagctggctt ccccaaaagc atggaatggg ggttggggat gggataagag agagagaatc  84541 caagacagaa tgcacagtct tcttataact taggtttaga aataatatat cagtacctct  84601 gccacattct gttggtcaca cacactaacc ctggtaaaac atgggagtga accatacagg  84661 gggaactggg gtcattggtg gtcatctttg aggctggcta tggtaattag gtaaaaataa  84721 aaattcagtc tgcagaaacg tatgtactta tgttacttaa aatattttaa ccaattagtg  84781 aaaaatgact ttgaagtatt tttagctgct ataataattg agtaggaatt attttttctt  84841 ggattgagtt atatttacta taaaaatact tacttttttt gtcaaacaca tttataagtg  84901 ctgcaaatat tagtgaccaa tggtctattg ctctaaataa aaagcaccag gagttagtat  84961 agtagttgac tccagcctct ggtgctagac tgcctgggtt tgaatattta cttttgcact  85021 tacaacttgt aacaacttga acaatttatt caatctctct gttccctagt tttctcatat  85081 gtcaaatggg agaaacaaat aacatctgct tcatatggct gttatgaagg ctaagtaggt  85141 ttatatatat gtatgtatgt atgtatgtat gtgtgtgtgt gcatatatat atatatatat  85201 atagagagag agagagagag agagagaaag agaacttaga atagggcctg gcacagagaa  85261 tatgataaaa gaatattatt tgtttcctct ttttatcatc cagaacatgg tgtaatgccc  85321 aatacattgt agatactcaa taaatgtttt tgtatgatcc ctaaacattg tctgtaagga  85381 atttacaatg gagtttacag taaaaggtgg tacatggtag gtaccatgga agcattacaa  85441 acagatgacc atgtgaatct gaaagaagca cagattgatt tcttcgtcat aaaacatggt  85501 tgtatttgag ctaaagctta gaactaatga agattattgc caggcgtggt ggctcacgcc  85561 tgtaatccca gcactttggg aggccgaggt gggaggatca caaggtcaga agatcgagac  85621 catcctggct aacatggtga aaccccgtct ctactaaaaa tacaaaaaat tagctgggtg  85681 tggtggcggg cgcctgtagt cccagctact caggaggctg aggcagaatg gtgtgaaccc  85741 aggaggtgga gcttgcagtg agccgagatc gcgccactgc acttcagcct gggcgagaat  85801 gcaagagtct gcctcaaaaa aaaaaaaaaa aaaagagtat caatgtatca aaatcattat  85861 tttaggctgg gcatggtggc tcacatgtgt aatcccagca ctttgggagg ctgaggtgag  85921 agatcacttg agcccaggag ttcaaggcca gcctgggcaa aatggtgaga ccctgtctct  85981 acaaagaaaa aaaaaagatt attattcccc aaataggaaa taacataagc aaacgtcccc  86041 tatttccccc acgatggagc tggagcatgg tgtatgagaa ggagagtcag agggagcaag  86101 aatgaagggg tcaggttggt accaggtaat gaaatcattt taacataaga ctacatgatt  86161 tggacttcat tgtgtggtca cttcggagca ttttagcaac aaaataatgt cttaggaaga  86221 ttaatctggt ccaattgtaa agtaaattga gattcaggct tcaggcttgg cttgatccag  86281 gattcaaata aaatcaccaa gaatctgtat ttcagatctg ctttttttgt gtggctctgc  86341 ctgtggctcc ataagaagca cagaaaaaag agaaatggtc tgttaaacag aaaaagtgaa  86401 aaagcttcac tcccagaaaa tatcttcttg catctcatcg gcctgagttc actcatgttc  86461 gtattcttca acaaattatc atgtccagga tatgaaacgg ctgcttggat ccaggcacac  86521 tgataacgct gataccacac ctagaaaaag aaatgaattt cattcaaatt ccattctact  86581 attttaaggt ttcatgtcta gatggctgga gattaagtgt tgcagtccag gcgtggtggc  86641 ccacgcctgt aatcccagca ctttgggagg ccgaggtgga cagctcactt gaggacagga  86701 gtttgagacc agcctggcca acatgatgaa accccatctc tactaaaaat acaaaaaata  86761 gccaggcttg gtggtgcgtg cctgtaattc cagctactcg ggaggctgag gcaggagaat  86821 cacttgaatc caggaagtgg aggttgcggt gagccaagat ggcactactg cagtccagtc  86881 tgggtgacag agacttcatc tcaaaaaaaa aaaaaaaaag taagttttgc aattaggaga  86941 catgcctata atgtttattt agtggtgata cgtatggttt agtcctttaa ttatagtgtg  87001 gtttaaatgc aaatttaaag taactcaaat acagctattt tttctcacat catagggaga  87061 ctataaagtc cctcagtaat cattcttcaa atagatattt ttcttctttc atctactgcc  87121 ttcacgactg cagtcacttt ctccaacagt cttttctcca aataaaaaca aaaacaccac  87181 taccaccact accaaaaatc tcaagtacct gctatctctg atctttctca tctgctaata  87241 ttctcttcct cccttactcc cctcctcttt tcttcctttc ctccttcccc atctctccat  87301 ctcacacctc cctctcttcc tacctccctt tctttcaacc ttttcccctt ctattcttcc  87361 ttccctcgct tcctccttcc cttccttcct tccttccttc cttccttcct tccttccttc  87421 cttccttcct ttttgctatt aaaaattcct caaactggct gggtgtggtg gctcatgcct  87481 gtaatcctag cactttggga tgccgaggtg ggtggatcac ttgaggtcag gagtttgata  87541 ccagcctggc caacatggtg aaaacccgtc tctactaaaa atacaaaaat tagtagtgta  87601 tggtggcacc gcacctgtag tcccagctac tcagaagggt gaggtgggcg aatcacttga  87661 acccaggagg cagaggttgt agtgagccga gatcgttcca ctgcattccg gcctgggtga  87721 cagagtgagt gagactgtct caaaataaca acaacaacaa aaacaaactg gcaatgcagg  87781 acttccttga aagacagagg aaaggaaaag attaagagaa gttataccaa aactcttttt  87841 aataggtagg cagggaaaaa attgggaacc tttatacatc aataatttta ttctcataat  87901 acttggaaat catgactagc tgttgctctt cttcaacatc taactattat catttccaca  87961 tctgattcaa gcacttcctt tttacatgtc tttttttttt ctttgcctga aatattattt  88021 ccttccatca aattaacctt tctgcccacc tggcaaccct ctcttcttca agccttactc  88081 atcaagaagc cttccctagc aacagggaag gctctgctac caatcccacc tttatgctct  88141 ctggactacc actttgtctt gtacatttct attaaattgt aacttttcat ttttgttaca  88201 catctattga ctctactgct cagtgaacta tttgagacca ggacaccatt ttgcatacct  88261 agcacaatac ctaccacata gtagacattt cataaatcct tattgattga ataaatcaat  88321 gatgaataac atttttataa atttcatttt gtatttgagt tgaagctcca agtattacac  88381 cctgttagag attttaaact tgatttttaa aatattggac tagagcttaa aagaagatta  88441 tattagtcag gggtctcaag agaaacagaa tcaataaagt atacatttat tatataattc  88501 attataagaa attggctcac atgattgtgg aggctgacaa gtctcaatac ctacagtcgg  88561 caagctagag acccaggaga acctatggtg tagtccaggc tcattccaaa ggcctaagaa  88621 ccaagcgagc caatgatgta gttctagtgt gaaaacctgc aggctctaga cacaggaaga  88681 agccaatgtt tcagttaaag tccaagggca ggaaacacca aggtcccagc tcaaacatag  88741 tgagacagaa ggaattctct cttactcagc cttttgttct attcaggctt tcaacagatt  88801 ggatgaggcc cacccacaat ctgctttacc cagtctactg atttagatgt taatctcatc  88861 cagaaacacc ctcacagaca cacctagaat aatgtttgac caaatgtctg ggcaccctgt  88921 tacccagtca agtggatgca taaaattaaa caccataaag actaaagcct gtagatgaat  88981 atctggtaac acctcacaga ggagagacct aaagctgtga taacgtctct gaagccaaga  89041 gagaaaggct agaaaaagca agatctggga tatttcctta gaatccttgc ctgaaggcca  89101 agaagatgag gaagttaatt ttctcatcca gagtggtggt atcgagctag aaaattgtga  89161 agatctttct agttctaaaa catctgttac ctccttacct tggggtttca agactgggta  89221 aatggaaata ctaagataat tggatgatgt aagaagattt tggatgggaa caatatcttg  89281 ttatgcacca gttgtatgga aactacttat ttataagatt taaaattcta cgtatattcc  89341 ttcaggaaat gttgtcggct ttctacaaga tgcagcttta attgtattat tgggaaccat  89401 cattgattat taggttcttt ggagaaattt ctttccttca attagaagca cccatgaagg  89461 atatgaagaa gagttggtca aagaactata agaagatcat agaatgtact gcactataga  89521 agccaaagga agaggtaaat caagaggcaa gaaatgatgg aaaggtattt tgctatagag  89581 aggtaaaggt tgataagact tgggaaaaag gccatcggat tttacgatta ggatattaag  89641 gacaagtttc agccaagtca tgagaaactg agcatcagtt aggtccctgt tgtttgatat  89701 tatgacaatg tggtggattt agtaattaga gtctttcaaa attgtctgtt agtgctttgc  89761 agcttggggg catgagcaga gaaggtaggg ggcaggagga atggggagca tgtctgtggc  89821 tgagagttga aggcttgaat ggtaagagta ggcttgagga ttgtggcttg ttagaaaaga  89881 cagcattaaa atatctgaac atgggacttt gtttttagaa aggatacaaa tgaagttaaa  89941 agccagaaga aggtcttggg tgggattttc aagctgcatt ccttggagtc ttgaatcgtg  90001 gattagagaa aagaccaccc tgtgttgatc tcagtagctt ctcctgttaa acatcacagc  90061 acatgtgctt tgaccagttt tgtatattaa ggctctatgt ggctatcttc tgtcccgctc  90121 tgtcccccac ggccattctc tttccttcac catgctgctc tatgacccgg gaggctgacc  90181 tatatggacc atatcagtgg gctgctttgc cctcctgctt ctgtttggat tttgcccttg  90241 gggagcactt gcatgagctt gcagggaggg agaatgagag gcaaggtata atctgctgtg  90301 acctacaggg tcatcaggat cctttcccct tcaggcctag agttggtaat aatgcccagc  90361 tttcttaggc ccttgaaatt tctctatacc ctgctatatc tgttcaattg cctacataac  90421 ttaaccagtg tatgcttact actcactgca gccttgatct ccctggctta ggtgatcctt  90481 ccacctcagc ctcttgagta gcbgggacta caggtgtgca ccaccatgcc tggttaattt  90541 tttgtatttt ttttgtagag acagggtctc accattttgc ccaggctggt cttgaactcc  90601 tgggctcaag caatcctccc accttggccc cccaaaatgc tgagattaca gacaagagcc  90661 accactcccg gcccaaacat tttttttttt tgtaaaaagc caggcagtaa atatttttga  90721 tctgtgagtt atacaatctg tgttaccacc acttaactct gctatctcag tgagaaaaca  90781 gccatagatg ttaagtaagt gaatgaatgt agcbgtgttt caataaaact ttatttacaa  90841 aaacaggcag tgagctttgc ttttggccca taggctataa ttgaaagacc catgatctag  90901 gacaagaagt tttccatcta ctctatgaga gtggttctca atctgggata atttagctcc  90961 ctaagggaca tttgttaatt taagacattt ttggttgtca caactggagg agtagtgcta  91021 ctggcatcta gtggataaaa tccagggata ctgctaaaca tactgcaatg cacaagacag  91081 cccccacaac aaaaattacc ctgcccaaaa tatcaatagt gctgaggttg agaaatgctg  91141 gtcttgaaga tgttaaaaag attgtcagtt tgttcatcat atcgctgtgg cttggcgaaa  91201 agaatcacag agttaatttt ataactatga aggattgtta ggagctgagt ttttttctag  91261 ttcttatttt ttaattattt tatgatactt ttcataaaaa gtggtgtaag ttgtgtttat  91321 tcagaaatgt gatttttttt tttttttttt gatggagttt cgctcttgtt tccgaggctg  91381 gagtgcaatg gcgggatctt ggctcactgc aacctccgcc tcccgggttc aagcgattct  91441 cctgcctcag cctcctgagt agcbgggact actggccacc atgcctggct aatttctgta  91501 tttttagtag agatggggtt tcaccatgtt ggccaggctg gtcttcaact cccgaactca  91561 gatgatccac ctgcctcggc cttccaaagt gcbgggatta caggtgtgag tcactgctcc  91621 cagcccagaa attgatggtt tctttagcaa ttttgtcacc catcaagtcg ttagtcatat  91681 taatcctcca taacttagtc tttttgcccc ctgattatct tttgggtggg cagtgaaagt  91741 attcatacct cttttagcaa aacctatctc ttcttggatt tcctttgctt gctgattaag  91801 aggaaggact atctgtgaaa gactcagatg tggctcaatg gaatgaatgt gagaatggta  91861 tgagtgtggg tggtgggtgc tgtgggggtc ggagatgagt ggctgaacca tccaaaaata  91921 agaatactga caagcgtgtt ttcttgtgtg tgtgtgcgtg ttgtgggagg agtgtaactg  91981 atgtggctag acaggattaa cgaaagtctc aggagttgag agagactggg gacattttac  92041 caatggcgag aaggaggaag gatgacagct gggaaaatta gtgattggaa aaggtaggct  92101 gggcagtgtg gccatgagct agtccttttc attatattct tctggggctc tatgtttaaa  92161 actagatact ttaacatttc agaatgagaa agagaggaaa ggatggtaac tgatatgggc  92221 tattatactg tgaattttaa aggagcctat atattatcct aaaactattg aacctgagca  92281 gaactgcaac gttggtattc ttgaactgaa ctgatatttc ctttgactaa tgtccttgtt  92341 caatgaccag agaccatgac actccccacc ttcaccccca cacattgttt gtttgtgtcc  92401 agtttgaaga acaatgacac atggaggtca gtgtttggat gatgtcataa ttttgatcag  92461 ctggaaagcc tggagtggcc ttgaagagat gcttaacttt tggaaatcac ttctttattg  92521 caaccaaagc tattaagttt aaaggtccat aaagatgaga taaacagtca taaaggcctt  92581 ttgaaattca tacttagtgt gttaaatgga tttaattgct gttagttaaa tgtggtgatg  92641 ttaaagcaat gtctatacac tggcaaaaat cagatcatca actgcttaat gagggacacg  92701 tcttgagaaa aacagtggaa gaaatgctgc ttatatgtaa tttgtgatta atttttgcaa  92761 ggttttcaag ggaataactt ggccttaaaa tattacagtg aaaaacagct ttatacttgg  92821 gtccaatctt cttaaaatta gagttcattt ttgctattag acacctttta ttacaggata  92881 actttttctt cccccttgga gacagagtct tgctctgttg cccaggccag aatgcagtgg  92941 cgtgatctcg gttcactgta accaccgcct cccaggttca agtgattctt gtgtctcagc  93001 ctcctgagta gcbgggatta cagtgcctgc caccatacct ggctaatttt ttgtatttta  93061 gtagagacag ggtttcatca tgttgctcag gctggtctga aactcctgag ctcaggcaat  93121 ccacccgcct tggcttccca atgtgctagg attacagatg tgagccactg agcccagcca  93181 gttataggat agcttctaaa cttacaatcc ttgaaatatc attttaggat aattctgatc  93241 ctgcatacca gtgaaataag tataattgaa atattaaacc aaatttggct tcaacattaa  93301 accaaaatta aaccaaatta agccagtatg ttaaatacat agtttaatct taattctagt  93361 taatattttt catttcctat gtgtcaggca atatactaaa caacttacat gtattactat  93421 tttaattctc ctggtaaact ggaggggtgt gcaattattg tcatctccat tttatagatg  93481 aagaaaactg agtcataaag aggttatgta cttggctgaa agtcacacag tcagtgatac  93541 tgttggaatt tgcacccaga caatttaatt ttagagccta ttttcaacca ctctctgaga  93601 ctgctttcct tttctgtact tttgatgata aatgtgaaaa gataattttg agggcattat  93661 ggtgtattgg atcttaaaaa cccaggtaat aagtcccatc tatagtacaa ataagctgcg  93721 tgatcttagg gaaatcacat aactgcttct gtaaaatgag agattacatt aagttatttc  93781 caaaatgtct tttcgacttc aatgtggtga ttccatagta atgtataggt ttttaaaaaa  93841 ccatatcctt caatcaaatg gtcatccttt agcattaagt tgtttggaat agatactccc  93901 caaattcaca gaataatttt ccagcctctc tttttgcttt gacacctttc ttattttttt  93961 tttttttctt cgagataggg tctcactcag tcgctcgggc tggagttcaa tggcacgatc  94021 ttggctcact gcaacctctg cctcccgggt ttaagcaatt cttgtgcctt agcctcctga  94081 gtagcbgggc tacaggcgtc cgtcaccaca ctcagctaat tttttttaat agagatgggg  94141 tttcaccatg ttggtcaggc tggtctcgaa ctcttgacct caggtgattc ctcggcccta  94201 gcctcccaaa atgctgggat tacaggcgtg agccaccgtg cccgctattg accccatttg  94261 ttgatgctta gggatgaaag tggaaactcc actgctaaaa cagagaatat tacttgagtc  94321 attcctctgt catatatggg atgtttgcca gcatggaaca ttcacagaaa ttataactgt  94381 aaaggcccta gcaatgattt aatgccgtct cttcacatta tagttgggga agctcaaact  94441 gtgacagggt cagggacagg taaaattcac aaagttggtt tacagcagaa ctgtgctaca  94501 gttatctgga ttcagatcca agtcccctcc aaatgaatca caaccacttc tacctttata  94561 attccaggcc atgaaagatc actgttttag tctgcgtggt gcagtggaac agatagacct  94621 cggtttgaat ctcagctcta ctgtttacta gacatgaaat ggggaaatct aaaatgagta  94681 agtatacaca gaaacacaca ttacatacat atatgtaatg ttcaggatca ttacactgaa  94741 ctttagggct tagtactaat gtacaatcaa ggttgtgtta gtactgagca gtatatcttt  94801 tattgttgaa gtccaataag aacagagcag atatcaacct aatttgtaag tgatgcattt  94861 tcctaaacta aatgcccaat aatggaatgg gctagaatat tgcaggacag ggctgtgaat  94921 ggaggaaagc agttggaaaa tcaatccttt taaaggcaca aaaggatgaa tgaaccacat  94981 tcccaagaac ctgctcccac ccactgctgt tcccaccccc gctgtagttg gtagcatgtt  95041 cacaaggaag gagctggcta gctttcatgg gagccacatc atccatcaaa tcacattagt  95101 gttgttgatt tgaatgttgt ttcctttgta ggtctgcttg ctttgacttt gtaaaattgt  95161 ttagtcttgc cattattata taaggactat aatcataagg catttatatt tcattttgta  95221 ttatgtattt aagcaaaatt aagttaaaaa ttagacagag atatatagga tgatttttcc  95281 ttcaagagtt attcatttat ttccttttgg atatgaaaaa cgcttatgca gtcctgtatg  95341 tggtctctct ctctttttat ttttatttat ttattttttg agatggagtc ttgctctgtt  95401 gcgcaggctg gagtgcaggg gtgctatctc ggctcactga aacctctgcc tcctgggttt  95461 aaatgattct cctgcttcag cctcctgagt agcttggatt acaggtgcca gccaccatgt  95521 ccggctaatt tttttgtatt tttagtagag acggggtttc accatgttgg ccaggctggt  95581 cttgatcctg acctcaagtg atccgcttgc ctcagcctcc caaaatgctg ggattacagg  95641 catgagccat tgtgcctggc ctgtggtctc tttttaaatg tttgagattt tctctgacca  95701 tcacatgatg gcagccgcaa gttgtaaata tattaaatga gataatacca aatggcataa  95761 gaccactgtg aattcagtga tgttccaaaa taacttgtat tttattcatc acacaggcat  95821 ttatataaat taaaaaataa tagcacctga aaacatgaaa ataattgtat tcaaggttat  95881 ttactgcagc atgattttta agagaaaaga ctggaaacaa cccaaatgtc cactaatcga  95941 gactgtgtga acccaagatg ttatagctgc atcacacagc tgagagaagg aataagatct  96001 atttctactc actgccagtg gtaatctcca ggaagcgctg ttaagtgaaa gagcaaacta  96061 gagaaaatgt gaatagtggt taccatttac ccaagaagtc tatgtgtggt gtgtgtgtgt  96121 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt atgtgtgatt tctagaggga cagaggaaaa  96181 aggtgaagac aaggatagga gcgagacttc tctgggtaca tctttttttt tttttttttt  96241 ttttttgaga caaagtctca ttttgttacc caggctggag tgcagtcgct tgatctcagc  96301 ttactgcaac ctctgcctcc ggggttcaag tgactctctt gcctcagcct ctcgagttgc  96361 tgggattaca ggtgcccacc accacgcccg gctaattttt gtatttttag tggagactgg  96421 gtttcaccat gttggccagg ctggtctcct gaccttaagt gatccaccta ccatggcctc  96481 ccaaagtgct gggattatag gtgtgaacta ccatgcctgc ctgtctggat ctctttttag  96541 tacatttgac tttgaagcca agttagtatt ttccataatt aagaaaaaaa tagaataaaa  96601 aaggaacaat ttctaaaaag gaagtcaaaa gaaacacatt aaactaactg taagttgagt  96661 tggtagcata accacacaga cagaaattat ttcaagtgac tttaacacat actgatgtga  96721 ctgtgcatcc ctatcgagat agaaataaag gtaaatataa ataaaggtaa aaataagcaa  96781 gatataaata aagttaaaat gaactgcaac aatcctgaat agttttcaat aattatatca  96841 taaatagtaa ttttggtatt gttattttaa aacagttata tttataatac atatgttaat  96901 gtaatcatgt ttatgcttat cataacatat ggatgcacag ctattaggat aatgtataaa  96961 catgattatg ttaatgccat tagggaccaa gatttcagag aaaaacaaag aaaaatataa  97021 aattaaagaa gccagtaaaa atgttatctt aaatttaaac tggaaacctc agtataaact  97081 cataatgtgt tttcttttaa aaaattattt tcaaattcag tctcctgaat agaactcgca  97141 acaattacca agccagtagc aacgacaata aacagcccta gtgcccagat ggtgctctcc  97201 aaatgccatt ttccactaaa aggaatgagg gctccttgga gaattggatg ttttcagata  97261 cagagcagaa cacatacaaa aagttcctgg aacatttgtc atactgaaaa gcagatacac  97321 tatgaaagac tatagtaatt gtatcaaaag aactcaggag ccaccatgaa gaggccccca  97381 gtgtccagaa atggaataat gtgaacatta agaataataa atcttaattt gtcaagatac  97441 aaatttaatc atatcgtaga tactcatagc agcattattt aaaataatga aatattagac  97501 acaacttaaa tattcaaaac tagcagtgtg cccttatata tagaaatgtc atttaaacct  97561 tgtagaagag aagtttatga tttaggaaga tgtttacaat atgctgtaaa acacacacaa  97621 caagtcataa aatattatgc atgcagtata ttccagttta ttttaaatga tctaggtata  97681 aatatccata aaaagaaaac tgaatgaata aatggtgaaa tgtgaatagt tgctatatct  97741 gtgtggcagg attacaggtg gttgtattct agtttctctt tatgttccaa tcttctacag  97801 ttagcatgta taattttata tttttttaat acaaaatatg ttatttaact agtatttact  97861 aaacaaaaaa ttaaaaatta atatatttta taaaaacaaa agcatatgaa tagaaaagta  97921 cattattttt taggttatag acaatgcttg tacctgtgtt tagggatttg atcctccagg  97981 taggaaacta cagatctaat ttaacttatt taattaatta attaattaat taatttattt  98041 atttatttac tttgagacag agtctcgctc tgtcaccagg ctggagtgca gtggtgtgat  98101 ctcggctcac tgcaacctcc acctcctggg ttcaagtgat tctcctgcct cagcctcctg  98161 agcagctggg actacaggca tgtgccacca tgcccagcta atgtttgtat ttttagtaga  98221 gacggggttt caccacgttg gccaggatag tctcaatctc ttgaccttgg aatccaccca  98281 cctcaccctc ccaaagtgct aggattacag gcgggagcca ctgtgcctgg cctaatttaa  98341 aaaattttta agtcaccaaa aagcaaagtg acatgctcaa gtccattatt gccaagcaaa  98401 gaaaaaaatg tcaaaagtac aaaatgtggt tatgttttaa aaattagatt attattatta  98461 agataggatc tggctctgtt gcccagacgg gagtgcagtg gtgtactcat ggctcactga  98521 agccttgact tcttgggctc aaatgatcct ttcacctcag cctcctgagt agccgggact  98581 ataaggcagg caccaccatg cctggctaat taaaaaaaga attttttttt tgtagcaatg  98641 aggtctcact atgttgtcca ggctgatctt gaatgcctgg actcaagtga tcctcctacc  98701 tcagcctctc aaagtgctgg cattacagtc ctgaaccacc atacctagcc agatttctat  98761 tactttgaca tggtcctgga tacttcatct atgtgtgcaa aatttcgtac ttatctctta  98821 aatctggaga aaaatggcca aatttggtat agttgaattt atcatggggt gattaataag  98881 tgactaaaga ttgaccttca aggatctgaa gatctgacca gtgtagattt atagtaatta  98941 tagtaattac atggtacctc caggtatttt ctatacattg ccgtagttag ctatgaaagg  99001 atgtaaagaa taaaggcaat tgactatttt aaagaaatta acctcagaag gagattcttc  99061 acctaaatgt ccctgcaaat attattgctt tatgctctga gttagctgaa aatgagttta  99121 ctatgcctgg tgtaaacact tgcaccaccc acctgtgtca aagaactttt cactaactgc  99181 atcatgactg attgacgtca gtctacttgg caaccaagtg agccacttag aagaaggctc  99241 cccttatgag gttaatttct ttaaaatggt gaattgccct tattccttat gtcttttcat  99301 aactgattac acaaatgtat agaaaatacc tcttgagata caatacaatc tgtaactagt  99361 catcagagaa taacacgtta ttgtaacaca gatttagctt ggccataaag ggcatattta  99421 catacacatt gaaaacaact ttaataaaat gaaaaacata tatccttgga ttcttagcaa  99481 tttaacagca atgctctcag gggatcaagc tactatttat tgactccccc tgtgtgcctt  99541 acacgtaatt actgaccctc acaacatccc tgggagttag tgtcttacag gagacctttg  99601 acatttgtga gaggacatcg tgaatatttt ccaagtcctc aatccaaaag tgtggacata  99661 gctgttggtt ttcctgaatt gtatttcttt caagaatcaa atgttgcttg tgaatattct  99721 catgtaagat taaaaaaaat cttttcctga ctcttagaac tttagtttta tctctgcttt  99781 gagagccact ttaataagca aactaaaatc actctacaga aaggctgtac agcaaatgag  99841 tagagaacaa aagctggcta aactgggcag tcagctaaga tcactcagtg tctgagaatt  99901 tgttctagaa aatcaccctc cgagaatcat gcagattgtg cttaggcttc cttcatatat  99961 tcatactctc ctcgggtgaa cataaattgg cacatttata aggaaatttt attattatat  100021 actcaaatat ttttaaacat ataaatagtt tgtcttgtta attctacctc ttggaatcta  100081 tcctaaggaa aataatcata agatatctgc aaagaattat ttgaatgttg ataataattt  100141 tatctataac aataaaaatt tgcaaggtgg cagatatcag tttatgtctc tgagctccaa  100201 atccaccctt gtttatcttg ctttgtgtga atggagctgg accctgtgga tctttctctt  100261 ttgcaaattt gggggatatt caactttgtc aattgagggc actggagaga ccctgcaatg  100321 gaatagaggc tccaggtgca cctacaggcc atctttccct accagcagcg atttcagagt  100381 aacttcagcc tgtccatacc ctccagcaat ggtgggtcac ttctatagat gaactctggc  100441 ccacccgcag caccaagcaa aggaaggtca ctcctgtaca ccagcttcca accactctca  100501 tccaccagtg atgatagatt gcttttatgg atcaatgcca gcctttgcac tcagtcgttt  100561 ctttgttcct gcaggctgcc tgtggtagtt actatctctc tgaagaggtc tgaatctcag  100621 ccttggggca aggagggctt gtcctcatcc ttagtgcctt tactgttctt cttcctcagc  100681 ctagaaataa tagctccttt taaaattctt gatgcctggg cctcttagag tcctccttta  100741 tatatctttt agtaggtaat ttttggaaca ttaaattttc cctgttcaaa taattatcat  100801 agtttttgtc ttccacttgg accttgaatg atacaaaagt taaaggctca acaataccag  100861 acttgttaaa taagtaggga gctatccaca cactggcata aaattgtttt gattatctat  100921 tattcccttg gtgaggtgac ccagaccctt gtttgaaagc gttttattgg ctgggtgtgg  100981 tggttcatgc ctgtaatccc agcactttgg gaggctgagg tgggcagatc acctgaggtc  101041 aggagtttaa gaccagcctg gccaatgtgg tgaaacccca tctctactca aaagtacaaa  101101 aattagctgg gtgtggtggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg  101161 agaatcactt gaacccgggt gtcggaggtt gcagggagcc gagattgtgc cactgcactc  101221 cagcctgggt gacagagcga gactccatct caaaaaaaaa aacaaacaaa agaaaaacaa  101281 caacaacaac aaaagaaaaa acaaaaatga aagaaagggt tttatttgtc ttctctctct  101341 ctccctgttt tttttttttt tctttttttt ttttttgtct catctttgct gtaattgctc  101401 atttgctagg gtcattggac acagagatac caagatgtct tcagaaatca tgaatattcc  101461 ccaagtcctc tatcaaaaag tgtggacaga gctgtcggtt ttcctggggt ttagacatgt  101521 tctttcttgc ttctgttgtg tagtaaccct agctcctcaa ggaaatcgtg gtctatgggc  101581 tctgccaaac agtaattcct ttctttgctt gctggctcac tggcttgagg aactcaaagt  101641 aatcctttgg taatttcagc ttccaggtca gtggggacat taatgtgttt cttggtagaa  101701 atgtcactct actccaagaa ataagatctt taatccagaa aacctgagtt ttcagggaca  101761 gaatgcacaa acttttatgg tcattcactg ggagttctaa tgagcaggtt cgatcatatt  101821 tctattcttt agttcctcga cccatgcatt ttagctactg ggcggcgaac catgtatcag  101881 ctgttagtgc tgtgtgtatt ccatatcatg aaggtaattt cccaggccca caacgttttc  101941 ttcccaagct ggtgccgtaa ctgagccttt accaggctat tccatcattt taggtgtttc  102001 tagggtatag agtaaatgat aagaccagtg actcccatga taaatgtgca ccatggtgaa  102061 cttcctttgc tgtaaaatgt catcttggtc ctagtctata tcgtaagggg caccatactg  102121 atagaccagg tactggtgag cccttggatg gtggtactgg tagaggaact gcaggaagaa  102181 aaggtaaatc catactcaga atatgtgttg attctggtaa ggacacgttg cttttccctc  102241 caagacagat ggttccgata gatggttgtg tagctaccct ccctgaggaa cggtactatg  102301 tcaaggtctt ggcatcagat tccgtggctg acaggttgga aatttagcat tgacagtagc  102361 tgaattatct tttgtaagtg ggagctcaaa tatgaccatg catagcacca tagtgattgc  102421 agcactagag acactattta tgggctttcc tgcacaagaa ctggggtggc taaagacggc  102481 ccggctaaaa ggcaggatgg atcatcctga gcacatggtt gttgagagtc ttctttgcag  102541 tcgggcggta gtgtgagatc tgctttgtgt ttatttccgt agggttgtcc acatacattt  102601 ttttccccac accttttctc tgagcttcaa atcttttttt cttgtcctgt cgaaatggcc  102661 aagccattca ctactgctta gaagccagtg catacttaag gatctggtct tttcttccat  102721 atgaaatgaa taactaagtg tgttgctcat agttttcccc actgggagga tttcccttta  102781 cctctcttct ttggggccac ctcaagtgag gatgaaatgc aacagcagac tatctctggc  102841 tagaggcaat aaatcacact agcccaatta tgcaccaggc ctgagctgtt tcctccacta  102901 ctgattgttt gtaggtagca gttgtgggag cttctgtgga acagattcag gtggtacagc  102961 tgctcaaact cataactcac ctgcaatgtg ttctgaaaat gtgtggctta actgcatcta  103021 ccctaaaaga acaagttggt gagtgatgag atgagtggga agtagtgagg atgacctgga  103081 ttttccattg aggaagtggc caagtcctgc ggacaaattg tacctaggaa aaggtacaaa  103141 aacaggagaa tggatcatgc gttcagtatt ggaactgatg actattaagt tgctgtgggc  103201 atctgaatat agatgttgtg atggttttaa aacatgtctg aaaattcttt gacactgttt  103261 ccatcaagag gtgatgtctt tgtctcctcc ccttgaatct aaatgggcct ttgtgacaga  103321 tctgatgaat agaatgcagg aatgtgatgt ccaaggctag tttagaaaag accatgtttg  103381 tttctctgga gacacttgct ctgggagcta ttagtgtcct tccaccaaag ccccccagga  103441 acacccctgc agctaaacaa attggattta ttgcttattg tagcaagaca gaacattcac  103501 cagggggaac cataggttat ctcagtaaga gggttttaga aagaacctat tataagattt  103561 gggctttggt tgggtgattt gggggaaggt ttaaggaatc aggggtggcc aggcacggtg  103621 gctcacgcct gtaatcccag cactttggga ggccgaggca ggtggatcac gagatcagga  103681 gatctagacc atcctgacta acacggtgaa accccgtctc tactaaaaat tcaaaaaatt  103741 agccgggcgt ggtggcgggt gcctatagtc ccagctactc aggaggctga ggcaggagaa  103801 tggcgtgaac ccaggaggcg gagcttgcag tgagctgaga tcgcgccact gtgctccagc  103861 ctgggtgaca gagcgagact ctgtctcaaa aaaaaaaaaa agaaaaaaaa aaaggaatca  103921 ggggtttggt ctagattgaa tgctctcaga aaatgggagt aattctaggg ttgtatattt  103981 tataggtggc atagtgacct tgttttgtct gtccttacac aaatgatgaa gtaggctgat  104041 tttgtttcat tttatcttgg tcgcagagta actttgtctg aggttggtgt tctataagat  104101 tgtatatgtc caacaagaga atgacatggc ttagctgtga atgtcagatc agttctggat  104161 atgagaggct gatattttct ttttgagctt tcagttgtca tgtaaggagt gtggctacca  104221 tgaggccact gcatagagtg attgtatacc tatatataag agagatggtt tggagttcaa  104281 gcccccagct agtcaagtct tcccagccca ggagacagat gttcgaatga aggagactta  104341 ggtaatttca gccccagtca ctgtctgacc acaactgcat gagagaccct gagggagaac  104401 tgctttgctg aacccagtca acctccagat ttgtaagtaa aataaatggt tatcattgat  104461 tgaagtcact gttctagggt ggtttttcct acagtaatgt cattgataca ggtgtctggc  104521 aggcagttgg ctctagaggt ctggagctaa ggagaaagat ctggcttgga gatgtggatc  104581 aggaagtcct tttacaagga gaaaagtgct tgaagtcatt tgagtggatg acatcacctg  104641 aaagataata tacattgaga aagaaaaaaa taaaaagcca acaatagcac ctttagtaac  104701 aacactgaag agagcaggaa gaaataaaga aacatttgca aggagacaga gaaggagtga  104761 ataaggtgat caaatggcat ccatccaaga gatgatgtcc aggaagccaa gaatgagagt  104821 atttcagaaa gaagagtgtt gtccacagag ttaaatgcta tggagagaga tggagtaaga  104881 caagattgat tagcaccaat gagctttcat tgttgacaaa tgcagtttga gggaaactgg  104941 gggctaggga gtgatggggc agagaccaga atgcagtggg gtaaggaggg gtaagaagat  105001 gagaagaatg ccaaatctgt gctgtttgcc acatcatggg ccctctctcc atactattta  105061 tgtgtgtata atttttttct acaatttaat aatgcattaa accatcacat cacatcacat  105121 cacaaaccca acaattccac aatagcatgg gtagatcata ccctggtgta tttttaatgt  105181 tatactttaa ccggtagttt tgagtcataa atgtactact atgttgttgg tttttttttt  105241 ttttttgggt ctgtcattat agtaataact ttaaatctct tattgtttat ttctcttgca  105301 attaaaatag ttcatcattt aaaatagtac ccagtgttca gtgtccattg gtgccttgta  105361 attacttcag aaaaacagtc tcagtttaaa agttataaac tcttaatgcc tctctgcagg  105421 aggaatagct tccttctgcc agagcggtct ggggagcatt attctagtca taccctgcta  105481 attcattggc ttgattgtca ggggtcctga tctagttcac cctcctggga ggctggtgtg  105541 ggaccctgct tatcccagtg ggggtcaagg cctccttgac aacagtgaat gggttgctag  105601 gaggctgcgg aaagaaattt ctctagttcc atccacaagt agatcccact gcagtggcct  105661 catttggctc ctctaatcct ctctttccca ccttctttca gggcaagtct caccctattt  105721 tcttcattac ttgcttgtgg tttccttgcc ggagatgctt ggaggcaagc attatgacaa  105781 ggatgggcgc gggtgggagt aaggccttta aacgaagagc tacatttcaa agaacttcaa  105841 atgtgtattt caaatgtcac ttccaaatga ggttgtacac acagacagaa acgcaattaa  105901 cagatttgga agaggccacg tagcatgcat ttgaaactcc tgttgcattc cttggctatt  105961 cttgtctgtg gcatcttttt aacaaatcct gtagttacct tgtaaatacc atcatagaat  106021 atattgtatt taaaaaacat tctttactca gatatgaaag ttgaaaaggt actattattt  106081 ttaaaaatct gtattggatt tttttttttt catattttag gatgccagaa gcctcaaaaa  106141 tggaaaaccc cctgtgcttc acatctgaaa atctctgctg ggggcagcaa ctttgagcct  106201 gtggggaagg aactgtccac gtggagtggt ctggtgaatg cttaaggagc tgcagaaggg  106261 aaggtagtga ggagacagtt aaatattgag cacgttttgg tgcctagcat tgtactggcc  106321 tttcacatgc tatgtttaat cacgcaggat tgtatggaat gggattgtac agaatgaggc  106381 ctgggtttgc taaatcctgg gggagattgt ctaagcbgtc acttgaaggg aaaactgtag  106441 catgbgggac ttaaaaacag cttgggatgg agtttgaggt agggcgagag ggaaaaagat  106501 cttggcagat acattctgaa caaatacttg tgtcatcctc aactgtatag tttttatgac  106561 ttttcctgtg ttcatctggt tggcagatga atgcaaaatg ccttttagct tcatggaagg  106621 cacacatgaa tcatggctat gtgataaaca gaagaagcca cgtttcggag ggtttctggt  106681 gtgtgtacgt gtgcacttgc atgtgtgtgg gcacaccctt gtgccaaatg gaccaccagt  106741 ttaaatcgat tttcaacagg gcagatttca tatgcttctt tagtgtggcc caagtcaatc  106801 tatttttaga aggggaaagt agagcatgtt ctgaaagttc ttttcttctg ccatcaggga  106861 ttgtagtact ttttatttat agtaatttca ggtctctaaa tacttcaagc aaaattaatg  106921 aggcaaacaa aaaaaattag gtaccagata attggatcat gtgttatttt atagagagct  106981 ttatttatct tgcctttgga aagtataatt tgtatttttc aaaattatga ttagatctaa  107041 ttctttttca agatttactt aaaataaata tttctgccta ggcacaagac tgtgtatagc  107101 acaactggcc ttgtattatt gacttgatga tgcaaagaaa aatatataag aatcagtttt  107161 ttttaaatgt gttaatattt atcataatgg aaatagtctt actaattagc aataactaga  107221 aaaatgtcta ctatttattg agccactact atatgccata ttctttacct atgttcattt  107281 tctcttctat attcaaaata atcctataag gtgtgcttta tgatcaccat ttgttccaat  107341 agggtctcaa ggacgttagg taattattcc tatgacattg agcctatgaa tggcagagct  107401 gggagtttga acctaagtct gatgactctg aagcttatag tctttctata agcttcttca  107461 gtctgaagct gcccctcaaa gtcatggcaa taactgagaa tagcattcag ttttacagct  107521 aggaaggtag ttgtagttgt gtttattatt caatactgtc catattcaaa gaaccattca  107581 ttgagcttct attttactcc agtcacggtg ataaataatg cagaatctag agatcaaaga  107641 taaaatggcc ttgccctcaa ggaacccatg agctagttgg gaaaactaat aggaatatta  107701 atgattataa tgcagaatgt taggtgcaat gagagaggta acaaggtact actggggcct  107761 gacaaaggcc accgtttctg tgtgtgtgtg tgtttatgtg tgtttgggaa aaggcaaaag  107821 acacttgaga taaagggaac aacatagaca aaatcaaagg cttgagagca tataacttat  107881 atgagacata gcaaattgtt tgctttaact agaaaatagt ggttatgtgt ggcagactat  107941 gagaaatgag aatgtaagtc cttgagaatg ataactttag aaattctaca tttgggatga  108001 tcataacctt ttaaaattgt ctcaatatga tagatatttt ccttctgttt tggggtatct  108061 gtctttttat tttttatttt tttgaggtgg agtctcactc tgtcacctag gctggagtgc  108121 aatggcgtga tcttggctca ctgcaacctt cacctcctgg gttcaagcaa ttctcctgcc  108181 tcagcctcct gagtagctgg gattacaggc gcctgccacc atgcctggct attttttgta  108241 tttttaatag agatggggtt tctccatctt ggccaggctg gtctcgaact cctgacctca  108301 gatgatccac ctgcctcagc ctcccaaagt gctgagatta caggcatgag ctaccacgcc  108361 tggcctgggg tgtccatctt ttaaagacac actgtaagaa tcataatatt ttcccaaaga  108421 agaaatgtaa ttagtacaca attacatgtt aaaactaggt gttattggta attaaaattt  108481 aaaaaaatta acccaaccaa ataataaaac taatgaaaat atttaatatt ggtaagaaca  108541 agatgcgata agcatatttg tgttttgctg attggtctat aaagtggttc aaaacttttg  108601 taaactatat ataagctatt ttaaatgttt atgccctttg attcaatagc actaggtttg  108661 gtactttata ataggaaagt tattagaaat atttactgca gggtttcttc aatgatgagt  108721 tgtaagaatc agcctaagta gctatggtac atcactttga tgcaacttaa tgtgtcatta  108781 aaaatcatgt ttatgaataa cattccagat gcatttaata caattctagc tgaaaaaaag  108841 atactgaaac attttgtgtt tatatatgtc tgcatatgta tctatatata tccctctccc  108901 tgtcaatcta taaattaaaa actatacatt aaaaactgca aattaaaact atatactaaa  108961 gaaagaaact ggaaagaaat ccacagaatg ttaataatca tggtcattgt gttgagtggt  109021 aggactatgg gtaatttttt ctttctattt ttatacattt ttcacttttt tttttttttt  109081 caatttgagg cagagtctca ctctgtcacc caggctggag tgcagtggaa cgatcttggc  109141 ttactgcagc ctctgcctcc gggttcaatc aattattcta cctcagcctc cagagtagct  109201 ggaattacag gtgcacacca tcacgcccgg ctaatttttg tatttttggt agagacaggg  109261 tttcactatg ttggtcaggc tagtctcaaa gtcctcccaa agtgctgggc ctccaaaagt  109321 gcbgggattt ggcctcccaa aatgctggga ttacaggtgt gagcaccaca cccggcccat  109381 ttttcacatt tttaatgatg tttttaactt taaaagtaaa aatttgtaat ttaaaatttg  109441 tttaactttt acaaataaaa attacaaatg caaattaaaa ttgctatata tttttgttac  109501 tggacaagaa aagatgcatt atagagtctc gttttatttt gttttctgat aaatctattg  109561 ctggggagca tgtgcgtaat tcgttttaaa aattctcagt gttaactaga tttcttttgg  109621 gatagctctg ctgaactgga atgagatctt cttccccaga gccacttgct agtttgattt  109681 tctagaaaga gagaaattat agaaagctac aatctacaaa ttgctatgta ctacagtcta  109741 ctaaatagta taatacttta ttttgcaaac tatatctctc agagtacaag gctccacagc  109801 tagtcttgca ccaaatatat gaggttcttg aatagtcatt ttctcaaagt tctcatctct  109861 ttacaaagca agttgagggg ggaagcagag agagcactct ggtgcttcca aaagcatcag  109921 ccatccacac tctgcctatt gaaaacacca aatctgagca tgtgtgtcat tgtccaggaa  109981 taaacaatca caaaaaggca tcaatgaggc ctataaaaac aagagcgcat gcaagaagat  110041 gggattgtta tgaaacagga gcacaaggct actaaaagag ggcaagccta aaggaaaagt  110101 caccagggtg agatggaaat agatatagga agaatagtga acggtggcaa ggaagtaaag  110161 gaatacaaaa gtaataaaat atccattgca ttagtccgtc cttgcattgc tgtaaagaaa  110221 tacctgagac tggataattt ataaagaaaa gggtttattt ggtttatggt tctgcaggct  110281 gtatgagaag catggtgcca gcatctgctc ctggtgaggc ctcaggaagc ttctattcat  110341 ggaggaaggt gaagggggag ctagcatatc acatggtgag agatggagtg agagagagag  110401 agaaagagag agaggagatg ccagtctttt aaataaccag atcttatgtg aactcagagt  110461 aagaactcac ttatcatgag gacagcatca agacattcat gaggaatctg accccatgac  110521 ccaaacacct cccactaggc ccacctccaa catgggcagt cacatttcaa cataagactt  110581 ggagaggaca gaacatccaa accatatcac ccacattgag ggagcaagga gcagactcca  110641 tactgcagaa cacacatggg aaacaaactt gagaagtttc cccagggcat agggtaagag  110701 gacgaggggc tggaaaaaga aaggtaatgg atatagagga cagagaatgg agttcgaaga  110761 tacatctaag aactttacat attcctaagg aacccacaaa gataaaacaa acagagcaag  110821 tatgaaagat gtaatagaag caaatgaccc tgcattgaaa atgatcaaag tatgcagatt  110881 ggaaaggctc acaaattcca ataaaaagaa ttgaaaacaa aaaaaaatgc tgcaataaca  110941 ttctttaaac tatattaatt gtaaggtttt tacaaaaata agtactcagg cagtagtaaa  111001 aagtttgcga ataaagaaac caaaattaaa ctctaacttt tcttatgtaa taccaaattc  111061 cagaacttgg aaacatatct gcatgcttta ccagggacca gattatgagg cagttattta  111121 agattagaaa agttctcttt cattggtaaa ggcaacagaa agatatattt tagaggtaga  111181 agctctctaa catagacact attctgccaa aaaaaaaaaa taagataaat gtaacaaaat  111241 aaaatgagct tcaaggtgta ttttggtcac tgagagatga ttcaaaagaa gactttgaac  111301 aatgagaatg ttaacattta aaagaatagg tggaattttt ccttactcag tttgttcaat  111361 aaaatcatgg gtccactgta acctgatata tcttgttgct taaagggaaa gcttggccct  111421 accttttctg ctttcttctg tgttcatggt gtagaaaatg tatttttgtt aaccaattat  111481 ttacttcaca cttgaggtag actttgttgc catgttggat ggctattttg ttaggtcaaa  111541 cagttttctg ccacatgcct atgtgatttt aaataatgta gccctcaccc tgagcttctg  111601 ctatagggac cacatgcttt gtggtaacca ggtgctgcca aaattggatg atagcaggct  111661 cctgacccat gcctgtcaag tcataggtgg ttaaggtcat gggagttgga gtcagactgt  111721 ctggttccaa atccaaggtc taccagttga ttttgacctt aattttctta ttctgtaaaa  111781 tgagtttatt gattgttccc actcagttcg tttgaggtga ggattaaatg agttaatacc  111841 tgtaactttt tgactggcac aagacacaat cctattacat gttctgaaaa aaaattctct  111901 acatgaacca aaggaatgaa ttctatttcc tccactgcta ctacaactca acacttctaa  111961 tcaccaaatg tgtggaggtt tttctacatc agtttgtcag acacctacta tgtgtcctat  112021 aattcagttc agttctgaca ccatctacat ggaaacaaca tccgatccca tggactaaaa  112081 gctcagtctc ataagactgt ctataatggc tcaagtgggt tcttcttgcc tgctgcacag  112141 aaaaaccaat acatcaaggc agtggtgttg cagtagagaa agcatttgat aatcacaagg  112201 ccagccaagt ggaagcatgg gagataattc ttaaatctgc ctccccaaga gctcaggggc  112261 tagggttttt aaggataatt tggcagacag gggactaggg aacgagtgct gctgatgagt  112321 tgtggatgaa atcataggag tatccaaact gtcttcgcat gctgagtcag tttctgggtg  112381 gaagtttctg cgtgggagtc aatttcttgg catgagtcac aggtccgggt ggagtcagtt  112441 agttgccaga atgcgaaagt ttaaaaatat ctcagagacc aatcttagat tttgacaata  112501 gtgattttat ctataggagc aagaggggaa gttaaaaatc ttgtgacctc tggctacatg  112561 attcttgagc agtaactatt atagaaaggt aagctaggga acaatgtctg gttatcattt  112621 aattacacct acatcttagc agaatttaag ttcttctcat aagcccaacc ttgtggactt  112681 tcattagtct tacaaaggca gtttcagtcc cccaccaagg agggcattag tttcaggtag  112741 ggactgttat catctttgtt ttaaagttaa aaaaggcagt tagcttgtga tgttagaaga  112801 aagatgtcag atttctctca ctgtcataat ttttgcaaag gtggtttcat ggccccactt  112861 gaaatgagaa tgggaagtcc aggttttcac ctgtgcttta gactgggtgg agataaatta  112921 aaggttcaca ggacctcctc ctcagatttg accatttgct agaatggttc acggaactca  112981 gaaaaacagt ttacttattt gattaccagt ttactttaaa aggaaattac aactcaggaa  113041 gagccagatg gaagagaggc atagggcaag gtatgtggga aggagcatga agcttccgtg  113101 cattcttggg ctcatcaccc tctcagcacc tccatgtgtt cagcaacctg gaagctcttc  113161 gaaaaatgtt cttaagccag gtgtggtggc tcacacctgt aatccccgca cattgggagg  113221 ctgaggtggg tggatcatct gaggtcagca gtttaagacc agcctggcca atgtggcgaa  113281 accccgtctt tactaaaaag agattagcca ggtgtggtgg cacatgcctg taatcctagc  113341 tacttgggag actgaggcag gagaattgct tgaactcagg aggcagaggt tgcagtaagc  113401 caagattgtg tcactgtact ctggcctagg tgacagagca ggactccgtc tccaaaaaaa  113461 aaaaaagaaa gaaaagaaaa agaaaaatgt tccttcagat ttttatgagg gcttcattgc  113521 atatacatgc ccctccctgg aggttggtct ggaggttggg ctgaaagttc caactctaac  113581 cacatggttg atttccatgg caacagccct gcttatcatt agggacttcc caaaagtcac  113641 ctcattaaca caaactctgg tgtgactgaa taacaaaaga tgctcctgtt acctttattg  113701 ctcttagaaa attccaaggg ctttaggggc tttgtgccaa aaacaaacac tatatatatc  113761 ttattataaa tcacactatc tcacattatt attatttaaa atgataagtc agtcaagctc  113821 tcttttcttg agaatttgat ttgggaaact tcgagaatga ggcaaggagc agtgggaata  113881 ggagtttaaa gtaagcatag aaagcataga aagaagctag ggaatagatt aaggttgcaa  113941 ggagggataa caaatggaga ttaggaaata gtggagactg tgattaagca gagcctgtca  114001 ttaggcattt ctgatataaa cccagatgct gtcatatcac ctcactgaat gcttgccctg  114061 aaacacttgt tttagtgcag ataaattcat cacctaagga tggcttatcc tttctatggc  114121 cattgaactt aagagctcca ctaaatagga taactccctt tatgcbggga aatctaccaa  114181 aattacctgt gtcagaaggg taagaaaaga gaatccagga tccagaatgg gattgaagtg  114241 atctcccatt ctttttgtga tatttagact gccttctgcc tctccaatcg acagaataaa  114301 gaccaaactt ctacccgggt gggtagggct tatcctgagg atggagactt tctaagtata  114361 gatggtcaag aaactggtgc acatttaagt tagacgcatc tctaaattgt ctgggcttag  114421 actattctaa gaatgaataa ttatgaaaat tgaggcagct cagagactca ttttctaaga  114481 tttcaatata tgattagcaa agtgctatag aaaaaaataa aatggcacag tttggcagtt  114541 ggcatcttgt atctttctgt cccaggtctt tcttgtgctt gtaattcttt cattgataaa  114601 gaactcagct atctatccag gcgtgatggc tcatgcctgt tatctcagca ctttgggagg  114661 ctgaggcggg aggatcactt gaggtcagga gttcgagacc agcctggcca ccatggtgaa  114721 acccacatgg tgaaacatct gtactaaaaa tacaaaagtt agcbgggtgt ggtggtggga  114781 gcctgcagtc tgagctactc aggaggctga ggcaggagaa ttcctcgaac ctgggacttg  114841 gaggttgcag agagccaaga ttgcgccact gcactccagc ctgggtgaca gagcaagact  114901 ccatctcaaa aaaaaaaaaa aaaaggattc agcaatgtgt ggttcttttg aatctatggt  114961 atgtattagc acatcacagc agagcagagg ttctcaacaa ttgattttat tccccagggg  115021 acatttggca atgtctggag acaattttgg aacttagagg ctgatgctat tttggaactt  115081 agaggcttag atgctattgg tgttgtgggc agatgacaag agagattgca aacgttctcc  115141 aattcagaag gcagcctcca caaaaagaat tattcagtcc aaagtgttaa tagtgctgtt  115201 attgagaaac catgccctag agaagcagcc tagaactttg agtttttcct tttttttttt  115261 tcaatcaact aatgagaata aatgtggagg agacgggcaa aaatgtcagc agccccgtat  115321 ggttttcaaa atcatttcag atatttgcta ttcaccagtg tcagccaatg tgtttatttt  115381 tgaaaggtca gaaatttcat agggccagat tactaaaatg gttattatta tttttttgtt  115441 ttcaagagct tatgttagtt atctagtata gagaagtcta ccatagagat ccctttgttc  115501 tgagtactgg actttttcac ttaccaaaac tctcctactc tatacgttct tcaccgtgat  115561 aatccaagaa gtctgaatcc tccccatggc tctcccctgt ttccatcccc agtcggtggg  115621 tttcccacag gtctccagtg tgctttggaa gtaggaactc ctaacagatt cacagtttga  115681 acatggtagt cctctgagct gttcagtatt ttaaatctct ctgcagttag ttataatcat  115741 tcaactcttt tagtcattct tctaatgtca gtatagataa ctaaaagatt gtaatattag  115801 aagacctatt tcccagagac cacaaagaca atctcatgga agtcccactg tagtaaatag  115861 agtctatttt ctacccagca tctggtagag taattcagac atgtgttttg acagtttgcc  115921 tgaaagtaac ttgacaaata attttactaa agaatcctag aaagtcaatg gcaacatttt  115981 gttcattcta agttgttcaa gccacgtcct tagatgtggt tgattcaaat ttcttcagaa  116041 ctggaaaagc acaagagaat tagtattcca gtaataagga atcatggatt gtggcagtct  116101 ttttaaaaca taaactagtt tagcacataa gtggtggcct agtacatttt aaagtggagt  116161 ccaagggaag tttcttgaat tgctgtagtt cttatggtgt tctgctgaag ccgtgtagat  116221 cttatggtgt tctgctgaag ccgtgtagat attgatcatg ctgcctccca ccaccacccc  116281 cttcattcca gatctgctca aagacaactt agaaggtcct atcctggtct cctgtctgaa  116341 acatatactt tctctcctcc cgcccccagc ctgcccatac tattccaatc cttctctacc  116401 tattattcct ttgttttgtt ttcaatataa aaatcttatc tatttcttta tacgttaatc  116461 atctatcact ccccacacac tacaatgtgt gcattcattc cctgagtaac tgaaacctag  116521 aggcccggga gtcatttttg aaacttcctt tccttggctt tctcctctaa ctgctcttcc  116581 aattcatcgg ctggatttga ctattctaat tccaaatctg tctggaactc gtgtacctct  116641 cgcagtgtcc actgcbgttg ttctggtctg gggcacaatc gacactcatg ctcaccgaac  116701 tgcagcagcc cccttcctgc tgcttatttt gaccacacct ctttttgaac ctattctgta  116761 caaaggagct ggaaagagtc agtaaaaata cagagcatag tgttcattgc cttgcttgga  116821 caggacctgc catatgtgtc ttctctatag tattggctga atgcataaac agcgagaaat  116881 aaatgtgtag agagtaaatt gatagaaagc tgccctcagt catctcccat ggagagggct  116941 agtgatgact ggcgaaggtc acagagctac tatgtgttag attttggact aaaatccagt  117001 ttttctgaga acggtcaaga gtttatttat agaaaacatg ctgctttatc tcttaattcc  117061 ttctcactcc ctgcaaatta gtggcatttt agtttactta aatgcacaat tatttttaat  117121 tttgattgaa aaattaatac tcatttactt ctgaaaacta tttctttacc gaagagcata  117181 gagaaataag ggagtaattt atcaacctac cataggtgga atttttactt tcatctttat  117241 actttcttct tcattattgt tttttttaaa aaacgtaagt atgcatttat ttttataatc  117301 aggaaatatg tgaagttata taaatgtgta atgaatttca ttactgggaa ctaactgctg  117361 gtgatatttt acacttgatt ttagccaaaa ggccgagaag cgatgctggt gatattctaa  117421 tgtactataa cttattctaa tatttcatgg gatttatttg caattagtgt gatataaatt  117481 tccataatgt atggaaagat atattagaag atgctaacca tgggcttaag aaagtagatt  117541 tcataatttg aaacacggcc cacacaatta ataaatataa gacatttggc actctacttc  117601 taatctcttg atttttttta tagcaactgt ctttaagaac cccagcatat tcatggattt  117661 tttagaaacc taattatttc ctagaaaaat cctttgaaaa aggaaaatta tatttgacag  117721 ttttctaaag attttctgtg cagaagttgt atctggatat acatataaag ccctgaagta  117781 atctatacat tttatcgctg gtcttcagat atgttggcag agtcgctcgt gaaatatatg  117841 cttgaaatta atgtaattac tctgacattt gttattttaa taagcattct tagctaatac  117901 atagaggaat acattaaagg aactctaaca ccaaaattat cctttcttaa ttaaataaga  117961 aggactgcaa ttatttaaaa agtgtatgtc aaatctaagt tgccttcaaa tgtaatttaa  118021 ttttctgtta cttacatttt aaaatggcca tagctttttt cgttgttcat ctttcttaat  118081 tctttaggca ctacttaccc cccaactcca gcaaccaaaa ttaatcctaa tttgcatcac  118141 aataatttaa aatagatcaa agaaccaatt tcatagccta attcaaaagc atcatgcgac  118201 caatatgtag tattaataaa acatatttct ggttttgcca atccaatttt ttttttaatt  118261 aagtgcttaa cacagtgccc agcacagaaa aagcacttga tacatgtttg gtaatgtctt  118321 tgtgactgtc atttttacta atgttgtata ttggtactac taaagtctaa tgggatgctt  118381 gtattatggt gtgataatat agttaggatg accacttgtc atggctggcc tgtgagaatc  118441 ctgtttaata tctattgttc cagttttctc caacttaaca ttttagcact caaaagtatg  118501 tgatgtggag gataaatttt atggtcgcca atcctttatt gtaaagaatc gtgatgcaaa  118561 ggctccagtg tagtcatcac tcatctcttg atttaggcat ctaagctatc caggcatcat  118621 catgggggtg agcagcctga atgacagtaa gctttccaag tatggggaca tgcacttaag  118681 ataggtatag ttattccagt gccaatctcc tcttacctgc tgtatgtcaa gaatcaggca  118741 acatttagga aatgaaacca caagtctttg tctctttttt taccctttat ctcaaaatgg  118801 tttttacttg ggatttgttt ttttgttttt tgttttttgt tttttttttt gagacggagt  118861 gccgctctgt cgcccaggct ggagtgcagt ggcgcgacct cggctcactg caagctctgc  118921 ctcccaggtt cacaccattc tcctgcctca cctcccgggt agcbgggact acaggcgccc  118981 gccactacgc ctggctaatt ttttgtattt ttagtagaga cagggtttca ctgtgttagc  119041 caggatgatc tcaatctcct gacctcatga tccacccgcc tcggcctccc aaagtgctgg  119101 gattacaggt gtgagccacg gtgcctggcc tttagttgag atttgattat gaatgaaaat  119161 gtaaagaaat ttgctagatg tgtccatctt ttcatgtggc agacaatatg gactagatat  119221 atggtggtca aaattatgtt tgtgggtata gcctaatagc ctaaaccaat gacacttatg  119281 tggcagtttt atttatttat tttttctttt taagacaggg cctcactctg ttgcccagtc  119341 tggaatgcag tggtgcaatc tcagctcact gaaacctccg cctcctgggt tcaaatgatc  119401 ctcctgccta aacctcctga gtagctgaga ttacaggcat gagccaccat gcccaactaa  119461 tttttgtatt tttagtagag atggtgcttt accatgttgg ctaggcttgt tttaactcct  119521 gacctcaagt gatccacctg ccttggcctc ccaaaatgct gggatagcag gcgtgagcca  119581 ctacgcccag cctcaccctg gactttatga caatgccaaa tatatgcact gtgtcaaaaa  119641 cagtcctctt cactgtcctc cagtagaaaa agctcaataa tgggtctaca aactcctgga  119701 tttagtccag gctatgtaat ttgtggaact tagtgccaaa agtagggtcc tttgttcaaa  119761 aattattaag aatttccaga tggcaacagt ggaacagtca atgaagcaca ggatccttct  119821 gtccccaagg tcctgaacaa ctgcagaaac cttgtgcccg tgcattcatc cctccttctt  119881 ggatccttta cctgttgatc tccttcgttt tctttccaga caacaattat ggacaactta  119941 ttattaatat atgtgagcca ctgtgttcac tatcggaaat aaaaatatgc ttataaggta  120001 gtcccaaatc tttttttttt tttttttttt tttttgagag acagtctcgc tctattgccc  120061 aggctggagt gcagtggtgc gatctcggct cactgcactc tccacctccc gggttcaagt  120121 gattctcctc ccgcagcctc ctgagtagct aggattacag gcgtgagcca ccactcccgg  120181 ctaatttttt gtatttttag tagagacagg gtttcatgat agtggccagg ctggtttcga  120241 actcctgacc tcatgatccg cctgccttgg cctcccaagg tgctgggatt acaggagtga  120301 gccactgtgc ctggccccag atcttagatt ttggtgatta aggacttcac gaagtagatg  120361 aaataacacc cagaatttgg ctggtttatt ttctccttaa gatgctcagc tgtgattttc  120421 tgtatattag tctcaagctg caaattctct attccaggat cttatgatct gtgtcctaac  120481 tacatattat agggccccag tggtccctat gcctctggtt ctattgtcat cacacacttc  120541 ctgtttcatt cctatagaca gatttattca tgactaggga acagattatg ctagtaaagg  120601 tgttggttaa catgagttta aggcaagaac ttaaacgtaa atatctctag ggattggaca  120661 ggcaatatgc cttaaatagt aaagctatca ggtagggatt gactgcatgc ctgcagagga  120721 aactgctgcc tatttagcca cagaagatta ttgccatgta aaaatgtgag tatggtttgt  120781 cacatatttt taaagaaaag tcagaaatcc aaaaatttgt atgaaatttt taaacatttt  120841 atattgtcaa ttcaattttt aaaaagactc aatataggca gagaaaaata actacagccc  120901 aaggttaagc caagaagtat tgtttttcta ctttttcttc gtagtcagat ttgttcagat  120961 ataattcaga tgtaataaat aaacccttta agttctatga gttttaacaa acacctacat  121021 tagtgtgaca atcactgtag acaagatata gaataattct ctcgtctccc ctccaaaatt  121081 ctctcaagcc tctttgtggt taattctcct agctcctgac aatcgctaat aaatttcctg  121141 tctatagttt tgccttttca agagtgtcaa ataaatggaa cactactgta tgtagccttt  121201 tgagacaggc ttctttcact gagcacaaat aatttgactt attcacgttg ttatatgtat  121261 ttagattgtt tctatctaat tttcaaaggt tttttccttc ctttcttctc ctttcctccc  121321 tccttccttc ctttcttttt ttcttcttcc tccttttatt ctgccttttt tctctccttc  121381 caactttccc gcttttttag atatcacatg tacagaagta gattaatctt gatgtttatt  121441 tcataacata ctctcatttg ggcccatgca tggcttgtat ttcaatagct ctattgagat  121501 aaaactcata tacattcaca tggagaaaca gccctgtgga gggaaagaaa ttgatatgca  121561 gtaaactaca catactcatt tacaacttga aaagtttgcc atatgtatac acaatgaaac  121621 catcaacact ttcaaggtaa taacatatct cagtttcctt gtgtctttat gttattcttc  121681 cctccttcca tctgatctgc tttgtgtcac tgcattttct agaattttat gtaaattaaa  121741 tcatatagca tgtgctcttt tttttgtctg gcttctttca tgcagcacaa ttattttgcc  121801 attcatatca gtttttgtgt gtatcaatag ttcattctgt attattacaa attagcattc  121861 aattacatga atacattgca atttattcat ttgtgaatgg acattgcatt atttccagtt  121921 ttggctgtga caaagattca tgtggaagtc tgtataggga catatgcttt catttctctt  121981 gggtaaatgt cttagagtag aatgcctaag tcatatggta gatgtatgtt taacttttaa  122041 agaaattgcc aaattgttgt ccaaagtgtg taccatttta cattcctggc agcagtgtat  122101 gagagttcta gttcttcacc atcccccttc caacacttgc tatagtcagt cttgcaattt  122161 tagccatttt aataaatgtg tagtgatatc tcactgttgt tttaatttgc atttccctag  122221 tgtctagtta tgttgtgtct ttacttttgt ttatttgcta tcattatctt ccttggtcaa  122281 atatctgttt aataattgat acatttttta ttggactgtt tgttttctta ttagtaactt  122341 tggagagtgc tatatatatt ctggatacaa atcctttaac aaatgtatga tttgcaaata  122401 ttttctccca gtctgtgatt gtcttttcat tctcctagca gtcttttgaa gagcagatgc  122461 tcttaatttt ataaagttca ctttatgttt ttttttattt tgtggattgg acatttggtg  122521 ttatatctaa aaaaaaatct gcctaaccca tagccttatg tgttttcttc tagaagtttt  122581 atagttttag gttttacatt tgggtctatg gtccattttg agttaatttt tgtatatggt  122641 ataagatgca gattgaagat ttttttttaa tatgtggaaa actgattgtt ccagcactat  122701 ttattgaaaa gactaatttc tccattaaat tgtctttgta cctttgttgt gaatcatttg  122761 cctatatatg tgtgagtcta tttctgaatt ctcttttctg tttcagtgat tcatctatgt  122821 tgatgccaat gctacactgt cctgataact gtagttaata aagtcttaaa gttaggtagt  122881 aaaagtctgc tattttcttc cttttcaagg ttgcattttc ctattccaag taatttgcat  122941 taatcaaaaa gtacatggaa aatgtgtatt ataacaaaag gtatggaatt ttaaaatttt  123001 caaaattctt ttgcatcaaa gtaaatgtgt actaacttgt tataatatgt gtgaacagga  123061 gctagtttga ggcactaaaa aggataaatc atcaatttaa aaacagcccc tatcagagca  123121 acatgaattc tgataaaatt gaagcaagaa caaatatcaa atttatcgtg aagcgtgggt  123181 gaaaaaaggg tgaaatcatt gatgctttat gaaaaattta tggggaaaat gtcacattat  123241 caaacagata actcatttta agaacagatg atatgatgtt gaagtcgaag cccacagcag  123301 cagaccatcc acattaattg ataggaaaaa aattcatctt gtttgtgtct taattgaaga  123361 gcactgatga ttaacagcac aagtaatagc cacaaccata tacacctcaa ctggctcagc  123421 ttacacaatt ctgactgaaa aattaaaatt ggccaaagtt tccactctat gggtgccaaa  123481 accattgtgc ccagatcagc tgcaggcaag agtagagctt ttgacggaaa ttttaaacaa  123541 gtgggatcaa ggtccagaaa gatttcttaa aagaacatta ataggagatg aaacatggat  123601 tatcagtatg accctgaagc caaagcacaa tcaaaacaat ggctaccaag aggtggaagt  123661 ggcccagtca aaataagagc agaccagtca agagcaaaga tcatggcaac agttttttgg  123721 atgttcaagg cacttttctt gactttctgg agggtcaaag aacaataata tctctcatta  123781 tgggagtgtt ttgagaaagt caaagcgtta gcagaaaaac gtctggcaaa gcctcaccac  123841 agagtccttc tccaccatga caatgttcct gttcattgtc acgaaacaag ctctcacgaa  123901 ataaagctct aattttgcaa gaatttcaat gggaaatcat taggcagcca ccttacagtc  123961 ttgatttggt ttcttctgac tttttgtttt ctaatcttaa aataatcttt aaggggcacc  124021 catttttcct tagttaataa tgtaaaaaag actgcattga cataattcaa ttcccagggt  124081 cttcatttct taaggaatgg actatttggc cggtatcatt gcttacaaaa gtgtcttaaa  124141 cttgatggag cttatattga gaaataaagt ttatattttt cattttaatc ttttaattat  124201 atttttccac aaaatttttg aagtcctctc acatatataa atttttggaa tcagcttatc  124261 aagtcatgta catttactgc tatatcacac tctgttttgt gaatattcca aaattatagt  124321 ctatgattta tattgttgtg actattgcat aatttacata tcaatgtact gatgatcata  124381 ttttgcaata tttttgttat tgttattcta ttatgaacag tgctactaat ataaatagta  124441 tttgccacct catacacagg tgcaagttta ttgtaatagt cttagtatta aattttctga  124501 gtcatagttt agcaaaagct caacttttca caggatattg ctggattgtt ctccaaagta  124561 gctaagttat actcctatta gccgtatatg agagattcta atcatcttca ttcttcaaca  124621 tttactattt tcagacttac taattttgcc agaaaaaata catgacaatt catacccgta  124681 cctgtagtgg tcttgatttc catttactca gaagacattg gacttttctt cttatgttta  124741 tgggctatat tttcccttct tttatgatat tactgttcat gtttttgctc atcttattgg  124801 gttatgggcc attttatttt atttttattt tttatttatt tatttttttt tgagatggag  124861 tctcgccccg tcctgcagac tggagtgcag tggcactatc tcgactcact gcaacctcca  124921 atgggccatt ttatatccta acatatgaag tatctgttca aatcttttac catttttttc  124981 ctgtaggtgt gcttgtcctt ttcttgttat aataaaacag ttctttattt ttgatactaa  125041 tcttttagaa agtgttctgt tgggcbgggc atggtggttc atgcctgtaa tcccactctg  125101 ggaggctgag gtgggtggat tacctgaggt caggagttcg agaccaacct ggccaacatg  125161 gtgaaactcc atctctactg aaaatacaaa aattagcccg gtgtggtggc gggtgcctgt  125221 aatcccagct actcgggagg ctgaggcagg aaaattgctt gaacccagga ggtggaggtt  125281 gcagtgagct gagagcatgc cactgcactc tagcctgggt gacagagtga gactccatct  125341 caaaaaaaaa aaaaaaaaag agagagaaaa gaaaatgctc tgtcagtggc aaatatctct  125401 tacttttttt ttagttttct ttgaaacctc ttttaatgaa tagaaatttt tttattttaa  125461 tgtagtttaa ttcatctatt tttctttttt aattgtcttc agtttcttta gtcttgtttt  125521 cataatcttc tggatatgag tcttgcaaaa catcttttgt taattttctc atggtttttg  125581 ttataatagt atttagagtt attttatata tttatggtta atataaatca aattgcatgt  125641 tgttcttgct ctaaattaca gattcaataa tttgcaacaa aaccttatct ctttgtaagt  125701 ccttaagtta attaagtact ctggatatct tcacatataa atacttgtat cagctgtctt  125761 ctctcttact actccaatta aaatccagta tctagaatag ggaaaaacca ggtgaacatc  125821 acccttacag agatttattt taagacataa tttagggtgt gctccatact gccttggcta  125881 tgtactagtc tatatattct agaagggtca tatatgtgca caaattgatt tgtgtagcca  125941 aaagctgctc cagtataaat gtgccaccag gatccatttc aaaacattgc ttcctcttgc  126001 caaggttagt gcagctatgc ttgctatcac tcaagtaacc agagaatgcc agcgtccgta  126061 ctctcaaaaa gacagccttt tctgcaccat tacaattggt gtcttttgtc cctttctttt  126121 cactgatgga aatctttttt atcattccaa tcaaagatca ctaccttcct aggagaagtt  126181 tcaatagaaa gaaaaaaatg ttatacttcc tcagaaaaat agcactttct tcatatagca  126241 agttttactt tcagaaaagt tgagaaaata aatactatgc ccccaggttt cccgttattg  126301 gagattgatt gctatgttga atgtgctata gctttgctgc ttaaacccaa acgccaagtg  126361 caggagtatc ttctttacta acgcatttaa tttaccaagc acacttagtg gctggtattt  126421 cttacctttc taagggtgca ctcacttaca ctgccctcaa tatatgtaat taggataaaa  126481 ccatagaatg gaaggcatta aaaatgaggc aggaaagcac aggcagagtg ggatgaagcc  126541 agctttgctc tgaataggac ttatatgatc agtttagttt tattccaaac atgaacccca  126601 aattcaaccc ctttgacctg agtactccgt cccttaaatg gcaaactaaa cattcgtgaa  126661 aatttaatgg tgaggaaatg agtaccttct taagtttcag atggtgaaat ggcaccaggg  126721 gagcactttc agtggcaggc agaagtgtgt ggatgtgcta gatcaaacct gaaatatttg  126781 ttccttcatc ctgcagtccc tctccaaact agccagccac tgagaccttc tgacaggaca  126841 cccccaggat gtcacccaaa aaaggtattt acaaaatcaa gactgtctgt aggacactat  126901 gtctttctga gaggtataaa ggtatttgaa aactttggaa agtttgtttt acaatttttg  126961 ttccctcttt tggggctttc cctttttcat ttttttctgt gggtagtttc cctttgtttc  127021 ctgagaaatt gagaagggtt taatatctct ccaccttctt ctcttttatg gatgaatgat  127081 ttcaccaact ggtaagtgct aaaactgacc tcgctttcac tcagaaagac aatggaggaa  127141 aggaaaatgc actgagattt cagcatagca actcaaatgc gggctttatt ccacagcagt  127201 gacctattgt cagattggtg tgtgagacag tttttgaaag gggatgtgtt ctgcttccgt  127261 ttatgagtta agcaaagttc taaattaagt tgagaagagg aagcaggtaa agtcagggat  127321 agcagagaaa ggagacatca aaccctattg ttgtaggata tttatgtgaa ggaatgagca  127381 acgtgataaa acacattttt gcttgcbgtg acttgccata gggtgcattt tcagtactgt  127441 gtggataatg tgtggcatgt tcattcatca gtcattctgt gacatttatg tagcttacac  127501 ttggatctat tttcaacaac atttcagttc cctaaagaca aactggcaga attttcaaat  127561 aggaaaaacc tggacacaca catttgcttt tctgtataga ctgtctagtc cagataatct  127621 tgctatcagt cattttgtta gcttactcat ttaatcttag aatggaaagt ggaaacagag  127681 acctcattta gagataatct agtaaagcca tccagcttca ggctcatatc ttgggaatct  127741 gagcagtacc ctatttaata tgctcatttt attaacttta aacacctgga gaacatcatt  127801 attgagaagg tcattgcttt tgaaaaaaca aaaacaaaac aaccacttct tatgaggctc  127861 tacacatctt tccaaagaag ctattggaaa tggcccaaac tttcatatta actcttaaca  127921 gggtggcgtg gtttttcatt agtaagaaca ggattcaaat cttatggaag atggtagatt  127981 tcaacacctt agcatttttc tcaaccctgg gatcttcaag ttcctcaggc tatttaggta  128041 gttatagtgc tggcaaactt tttaagtgcc cagtagtttt tacaaaaact tgtaataaat  128101 ctgctcaggc tatcttaatt gccaaccatc tcattaagca agtcaaatta gaatggatta  128161 ttcctgctgt ttattagtgc tgcatattat ttatcattta ttaaccttat tgtgctcaca  128221 tagcaggtat tttaaagttt aacagcttta ttttaattat gaatgtaata tatgctgttg  128281 cagaaaatat gtaaacttta gagaaaatgt actaaatgat gcactgatga aaatacagaa  128341 tcccaccaca aaaatattat tatcaacatt tgggtattct cttccaaact ttttatatga  128401 gagttatgtt tggtttatac ataataaaat gggtaaaaat caataaatag aaagcaaatg  128461 tttttaaggc agtacttggg cttcataaga atggaaaaaa atgatagact tgcctggtgt  128521 ggtttgcata atgtcacaga atcataacaa tagctccatt attgagtgtc tattatgtgc  128581 caggttctgt acaatgttca gtgatgcgtc actgtgatga ctagaggtaa aggaaagata  128641 agtgatgcct tactatgatg acttccaaca agctatgaag ggacagaaca agcctttttt  128701 tttaactttt attttaggct tgggagtacg tatgaaagtt tgttacatag gtaaacatgt  128761 gtcacagggg tttgttgtgc atattatttc acacccaggt acctatgtcc agaacccaat  128821 agtttagttt tcttttctcc tcccctccct cattctatcc tcccccctca catagacccc  128881 agggtctgtt gtttccttct ttgttttcat aagttcttat cattatcata cttataaatg  128941 agaacgtggt atttggttgt ctgtttctgc attagttggc taaggataat gtcttccagc  129001 tccatccacg ttcccacata agatataatc tcgttctttt tttatggctg catggtattt  129061 catggtgtat tttatatata tagatatata gatatatata taaatatata tagatatata  129121 tataaatata tataggtata tatatgtcac atatatatat cacatataca aggatatgtc  129181 ctctagctcc atccatgttc ccacataaga cataatctcg ttcttgtttt atggctgcgt  129241 ggtatttcat ggtgtatttt atatatatat atctatataa aaatatatag atatatatat  129301 cacatatata tagcacatgt atctatatca catatatata tatatcacat tttctttatc  129361 cagttgggac agaacaagtc aactggcaag tccattgctc agcttgttga aatactctgc  129421 acagaatgca aggaaaaact gttttcatga ggtagcccat gaagcgatga agcaaggcaa  129481 atttatctgc ctggataacc tcctgtatgc tgttttcact ccatggagag tcaacacaac  129541 agacttctga gttgtattat cgagctcctt caacagggca ttgctgtaag atcctagatc  129601 ccacactcca tggtgtgatg ttttagccaa gtctggaagt agcacaggcc ctaaaatctc  129661 atgattgcag gttgtcaact ctgctgtagg cttgccactt caagggcaag tggttggttg  129721 gggctgggat ttgggcagag ccatagaaag aaagggaaca ttcaagggaa tttgatgatg  129781 tgcatgatgt ctctgtctga tacaaaaaga aaaaaaaact ctaaaaacat ttgatacata  129841 gaaatactag tatttggtga gattgaatgt gggaagatga gggataagaa ggtattaaga  129901 atgactccca agtttctgac ttggtcagtt gagtagaagg gaaattttta tttttatttt  129961 tatttttaaa atttcagtaa gtttttaggg aacaggtggt gtttggttac atgaataagt  130021 tctttagtgg tgatttctga gattttggtg cacctatcac ctaagcaggg tacactatgc  130081 ccaatgtgta gtctcttatc cctcaccccc catcctttcc cttgactccc caaagtccat  130141 tgtaacattc ttatgccttt gtgtcctcat aatttagctc ccaattgtga gtgagaacat  130201 atgatgtttg gttttccact cccgagttgc ttcacttaca ataatagtct ccaattcatg  130261 ccaacatcta ttattttttg attttttgat catgaccatt gttgtaggag ggaggtggta  130321 tcccattatg gttttgattt gtatttccct gataattagt gatgctgaac atctttccat  130381 atacttgttg gccatttgta tatctgagta gaaggtaatt ctaataaata aaacaggaag  130441 gcagcagaaa gaggtttgtt tgggatatgg cttgattatt tgcaagatat ttgctgtagc  130501 ttaggagaaa ggtggatgtt ggtgatactg attttgtcat tatctgtgag ttaaagtttc  130561 taaaatcacg tggcttccta gggaaagcat atagaatgac aagggaagat ggctagatgg  130621 ctagtaatgg caccctgaac aacttcagca tttagaggtg ggtggaggag gataagccca  130681 tggaagaaac agaaaggatg ggccagcgag atgagaggag aagctaaggg agtagacagt  130741 taccagaggg aaggtgggat cagttaagaa ccttagtatg ttgcaaagaa ataacctgca  130801 atgcggacca acccggggaa cgtctgtaaa aatgatgaca attcttaatt gtaatttaaa  130861 atgtaattgt attgagagct ctctctgtct ttgtctcatc ataatttgaa gcagattaac  130921 tacatattag ctagaaaaag ccctttgaaa ttttccttca atgtatcaat agattctatg  130981 actttttgta agtagaaact gcctattggt aaaatagcac ttaattgaga taatgcttgt  131041 gaaagccatt tctaaacttt gaattgacat acaaaataaa ggtggcaatc atcaccatgt  131101 tgctatactg tctttggcca tataaaattt ttttcaacaa tacaaagata agccttgtac  131161 aaattcttca aaattctaaa tttgtggtac ttgaataatg ttttactata tataaagatg  131221 aatagatagc atttcctaca ataaataaat aatttatata tcaatgtgtt gggattataa  131281 attctcatag aaattcactt tattaattca ttcattcatc tgatcacagt tcattcagca  131341 aataatttgt tttgttcttt ttaagtgctc tgggaagaag gtattgtgac agagtccctt  131401 ctctcaaagc gtttatagat tcatgtgttt ggggaaagta cagaacaatt attgaaataa  131461 aaccagagtc aggcacattg ctatgccagc tataaagagc ctatgaaaat taggaacatt  131521 gacacatttg ttcctaacct ggtttgtgct ttcaggattc ctctgaagtg gcagcactcc  131581 ttgggtttga aatgttcgtc agtaatgact gatggacatc aacaggtgaa tagacacaca  131641 aaaaacctat gaaacttaca taccataggt tactattcaa caataaaaag aaaaactgtt  131701 gatacatcta acaatgtaga tgaatctcaa aagcattatg ctattccttt ggctgataaa  131761 atggtgacac tcctttattt ctctttcttt catcccactt ttaaaatcag ccttagtata  131821 ctttaggcac aatatactat atacatttaa aatgacaatt tgacaagttt tgacaaatgt  131881 atatacatta taaaaatcat gataaagatt tccgccgcct caaaatgttt cctcatgcct  131941 tcttggaata aatccacaca ttccttcctt ctctacaccc caccacccat atactctacc  132001 tctagaccca agcaattgct agtctgcttt ttgtcagcgt aaattagttt gcattttcta  132061 gaatttcata ttaatggaaa tgtacagtaa gtactctttt gtgcctgact tcttacattt  132121 agtatagtgc ttttaagatt tatccaaatt gttgggtgta tcaataattt gtttcttttt  132181 attgctgagt agtattctat tgtatacgtg gttcacagtt tatccattca ccagttaatg  132241 gacattccag ttgttttata tttggggctg ttatgaataa agctgatgtg aacatttgaa  132301 tagaagtctg ttgtgaatgt ttggattgga attgcbgggt tgtacagtaa gtgtttgatt  132361 aacttcataa gaaactgcca aatgattttc caaagtggct acatataatt ttgcattttc  132421 accagcagtg tatgagattt ccagttgatc ctcatcctca ttcaaaacct ggaattaaga  132481 gtgaatcttt taaattttag ccttttgaga aaatgtgtag tggtacttca ttgtagtttt  132541 agttcgcact tctctaatga ctaatgatgt ttaacatgct tttatatctt cttttgtctc  132601 catctattct ttgttcttca ttctcttttc ttcctttaga gtaagtattt tttattttat  132661 tccattttca ctattggtat attatctata aattctttgt tgttgttcca ttttagtggg  132721 tttacaatat aaatctttaa cttatcacag tctgtcatca aataatggta taccccttac  132781 atatgtttta ggaaccttac agtggtaaaa atatcagttc cccatcctgt acttgttgct  132841 attgttttca tgcattttat tctgtatata ttataaactc tacaatctat cattattact  132901 ttttgtttaa atattaaatt ctttaaaaga gatttttaaa aataagaaaa tagtctttca  132961 tattttctca tgtatttgcc atttttattg tttttttttt cttccatatt tgagatccaa  133021 atttctatct ggtatacttt tccttctgcc tgaataacta cctttagtat ttttttgtag  133081 tacagatctg ttggcaatga ttatctgaac ttctgtatgt ctgaaaaagc ctttagctaa  133141 tttttgaaag ttttttgatg gacatatgat atggtttggc cctgtgtctc catctaaatc  133201 ttatcttgaa ttgtaatccc catgatcccc atgtgtcaag ggtgggacca ggtggaggta  133261 attggatcat gagggccgtt cgccccatgc tgttctccta ataatgagtg agtctcatga  133321 gatccgatgg ttttataagt gtctgacatt tcccctgctt gcacttctcc tttctgccac  133381 cttgtgaagc aggtgcctgt ttccccttca ccttctgcca tgattgtaag tttcatgagg  133441 tctccccagc cttgctgaac tgttagtcaa ttaaacctct ttcctttata aattacccag  133501 tctcaggtat ttcttcatag cagcatgaga atggactaac acggtacata caattacagg  133561 ttgctagtcc cttttttccc ttcagtgctt taaggatttc actcttccat agtttctgat  133621 gagtagtctg accattccta actttgtgcc attattttct catttttttc tgactctccc  133681 ttctgggact ccaattacaa atatcccaga cttcctaact ttggcaggtc aagagatcga  133741 gaccatcctg gtcaacatgg tgaaacccag tctctactaa atatacaaaa aattagccag  133801 gcatggtggt gggcgcctgt agtcccagct acttgtaagg ctgaggcagg agaatggctt  133861 gaacccggga gggggagcct gcagtgagct gagatcgcgc cactgcactc cagcccgggc  133921 gacagaccga gaatccgtat caaaaaaaaa aaatcattca aaagattact gatgcttgtt  133981 tcattttttt ttaatttttc aactggtaat taatttatta aaatagttga cttatacgtc  134041 tacaatggtg acttccatct caactcctgg ctcaatactg atggaagtaa tctgcttaac  134101 aatctcagaa ggactgagca agtcaatgag tcgcttgtgg attctcatct ggaaatgatc  134161 ccatggctta gaaccttcac cacatggagt tttttcttgt agtgattctc aaagtcttag  134221 taggcatttg aactggtctt ttcactttga gattcttttc ctttgctcct ctgatcaagt  134281 cagcacacac cttcgccagg gattttacat tgcagcttgt tagagtgatt cgaattcggt  134341 gaattgccat cttcggctcc gtgggtgttt ttccggtatc cttaaaagcc atcactgctg  134401 cgcggcttcc tgacctactt gttccggcaa gagtgaacag tggtgagtca ggagcaggtg  134461 cgggcggatc agagctccac aacacctacg accacctctt cttcaaagag gtgtttcatg  134521 ttttaaaatc ttaatttcct tctgtttcat tttggataaa atctgtcttc aagtttggtg  134581 cctttttttt tgggccaata tctaatctaa agttcatcct atccagtatg tttctcattt  134641 caaatattgt attttctatc tgcagagttt gatttgtatt tgaaaacgtt ttttaatctt  134701 tctcattgtc ttaaacattt ggagtatact tataataatt gttttactgt tgttatctgt  134761 tacttctatc atctatgaaa ttactatatc tgtttctatt gattgatttg attactattc  134821 tggttgggag gcaatatttt ccctacttct ttgcttactt ggtaattttt ttatcaatga  134881 aaatttataa aagtgaactt catttacaat tggatataat gaattttaca tttttgtgtc  134941 ctggattttt ctgtattcct ttaaatattg ttggatttct tttttttccc ccctccggga  135001 tgcagataag tttcttggaa ttagctggat gcttttgaga tttgctttta agatttgtta  135061 gggtgaattc agagcagggc tactttgatc taggaaatag ccctctgaag ggtctcatgt  135121 tctgtgagat aggaggtctt tctcctctga ctggttggta gcctaagcta ttcctgattc  135181 ttgtaaggtc tggacactgt tctgcatact cttttctgat agttctttcc ctggccttag  135241 tagttaccac acatctatgc acatagcggt attcagccaa agtttgaaag gattcaaaga  135301 tctccagagc tctctctgta tcactgtttc tgttattcta tcccacaaat tctaagtgtg  135361 tgaaactccc tgaaatcaga actatgtctc ctcaactcag tgagaccaca agccactgtt  135421 tgggtttccc ctgcccatgt tgcagcctag aaactctcct caggcaaaaa gatcaggcaa  135481 catcggggtc atctcatttc cttccctttc agagatcact gtaattgcct attgaacaat  135541 gcctgaagaa agatgtttca tatattttgt ctggctttct agttgcttaa ggtaagaagg  135601 taaatgcatt cctagttact gcattgtggc tgggagcaga attccaatac tgtttttttt  135661 ataatatgct tttacttaat tatttgagga ttccctttag ttatcataat tttacatgat  135721 gtaaacaggt aaatgagaat atcttcaaaa tatatttttc agttttgggg tggttctctc  135781 agttctggtt tttgccaaat ataatagatt tttagtatct gagttccata tgacaaaatt  135841 tataaatctt gggtgtatcc atatggtatg ttataatcgg aaaagataga tgaaattccg  135901 cttttgtcta atgtctttat aggtcttgga gaaacttgaa gaagggttgt aaagtccata  135961 actttacaat gagacaaaat taaaagaatc caagccaaaa ttgtcctaga caatgaaaag  136021 tatcgctatg cagaagccaa atctcttaag ctcctccacc atatcagtca tgacacagtc  136081 tatagtttaa caattgtttc aatttggaaa ttaattttta gtactaattt aaatatttca  136141 tattagtata tgagaattct tccttctgtt caggctgtgg tatggggaaa agtcagttcc  136201 catcaatgca gattcatatc taccagcaca gtgattaaat tatcctcata tcctcttgtg  136261 tttgaacaag ctgtgtactt ttaattttaa tggatttaac tcaatattca atatatgttg  136321 attactgaat acaacaaaaa gtgtaataga cactccttga gaagctcata atctatttgg  136381 gcagatggaa caaatactta gaaaaattga aaggtagttt aggaccacag taaaaaaaaa  136441 ttgggggtgc aggatataaa gtatcaattg aattgtagaa gcaatatata ctgtgtattt  136501 tttcacctgg gtgagagggt gagactccgt ctaaaaaaaa aaaaaaaact atggttgttc  136561 accataacta aacatttaat ctctttcagt ctatcttact catctacaaa atggagataa  136621 tacctgtttt gcagtgcagg ccctgacata cgggtagagt tccataaatc ctagcttcta  136681 ttccttaact cttttaactc ttttcttcct tccttctttc tagctaattt ttaactctct  136741 atcctagaca acttttgcta aacgtgtata acatgtagta cctacgcata ggaatatgtt  136801 ttatagaaca gaattattga aaacagcttc ttacatttct gttatttttt caaaagcaag  136861 aattcatgta ttccttctga gccaagtaca tgcaataaaa agtaagagag attcagaaat  136921 tctgatgatt attctcccaa gaagagtgct tgctagagtg agggtcttgc agacacagaa  136981 ggagctgatg gggtgaactg ctggggtgtt acaaaaggcc ttcgggaaaa tacgtaatct  137041 aagtcaataa atcatagagt gaagattccc tcagggaaaa agggagtggt tctgaagaac  137101 ttacaaattt ttccaggcaa tagccacaga tgctagcaca agggcattat ggccacatag  137161 tgtgagcaaa agtgcttaac tttttgccct tcttctaata tttactctat tagcccagac  137221 aacatgagat ccagaagcct catgatgagt ggagaggaaa tataaatcag aagaaatggt  137281 caaaaagatg cctatattca cttccgcact taggtctcca agcctcagtt cctggcatga  137341 gtaggtagag gagaggagct tggaatagga tgtgagatta cagttttaat atagactgga  137401 ctggatattt gaatacctga aaatgaatct gaattctcaa aatgaggtgg ttcctgcaac  137461 tgaaaataac aagaaagcta caggatcttc tgccatgtta tccaggggtg gaaaagtgaa  137521 attcagtgga gccaggttaa agatggagtt tgggccggga gtggtggttc atgcctataa  137581 tcccagaact ttgagaggcc aaggtgggca gattacttga ggccaggata tcaagaccag  137641 cctggccaac atggtgaaac cccatctcta ctaaaaataa aaaattagcc aggtgtggtg  137701 gcatgtgcct gtagtcccag ctactggggt gggtgaggca tgagaatcac ttgaacctgg  137761 aagggggagc ctgtggtgag tcaagattgc accactgcac tcccgcctgg gcaacagagc  137821 aagaccctgt gtgaccttgt gtccaaaaac agacaaacaa acaaatacca tgtggagttt  137881 gtttactctt taaacaaata tccttcatgt gttgaactga actataatta tagttagtag  137941 ggcacatagc aggttttaat aagatatcta gttcttcctc ttaaggtaac tcgttagaac  138001 ttttatgaga aagaactaaa gaatttctaa tggggcagct aatccactct tttgtgcact  138061 ctgttctgct gatgatctga tgttagtcgg ggtttctgtt tgagattcct gagccttaac  138121 tgctgatgac agagttcaaa atcattgctt tctaactttg agaatgactg cctaatatga  138181 catcattttc tacccctgag tgctaatagt ctaccttatt cctcctgcct gtccttctcc  138241 ttgaggagga ggatcatcaa tgcactgtgt ggattgaagt ggcttcatac ccttttgatg  138301 ttaatgttct cctttgctta aagtgtgaac tgaatatgga tccctcattt atgaagcacc  138361 atgacacttc ctgggtaatg aacaattaaa cagacttctc agcaatagtg actatttttc  138421 tgatttttca cttcatggac aatattgtat gcaagttaaa tttgcaacta gcttgaggct  138481 tcacacatgg tgagtttgag aaattgaatt ctctacctca aatgtatttc cttttccttg  138541 aactctacat tcaggtcagc tgtccagttc ttaaacaaca ggttttggag aggcaatgag  138601 taataaaata gcattttctc cttcaattct atctgcattt gaaaaaaata accttttatt  138661 tttgattcaa agaagagagg agttttcttg tctttctaca tctgttccaa ctcctccaaa  138721 tgcacaaaaa ttttttcaga gcattccaga gtttctcaga ctgcacatag aagattttgc  138781 atatagatac atcttggcca taataacctt ctactgaatt agtagaaaat agatgtattc  138841 taggttttca tatctttatg gcaatatgaa tagacaaggc tcttcttgca aaaatatctc  138901 ctgaactgtg cgggagatgc ttggaagacc cagtcaaaat tacgaagtat cccaagtttg  138961 tatcctcctg tggcttcccc gtattacaat aatgtcattc tgatccaggt tccagtactc  139021 tcaagccctt gtccttccct tttcatttta gcttgcattc atccaagtat ttggatggaa  139081 attatcaata ccttatacga gaacgtatgg gaggctgagg cgggcggatc acgaggtcag  139141 gagatcgaga ccatcctggc taacacagtt aaaccctgtc tctaccagaa aaatacaaaa  139201 aattagccat gcatggtggc acgcgcctgt agtcccagct acttgggagg ctgaggcagg  139261 agaatcgctt gaacctggga ggcagaggtt gcagtgagcc aagatcacgc caccgcactc  139321 cagcctgggt gacagagcga gactcatctc aaaaacaaac aaacaaaaag aatgtaaatg  139381 attgggagtt aaaattatgc ttttcagttt tcagccatgg atcatgtttt cttgccttgc  139441 ctgattccta gagtctcact ccatgatgtt tcctctttat tataaagatt agatggcttt  139501 gcattgctgc catgtggcat ttatacttct caagcagctg tgtcatctta ttctaccgtt  139561 taaacttagt tttactttaa gtccacatct aaactgtttg cctgcatgcc cagcactttt  139621 tccaccctct acattttatt tgactggagc aatcacctta gcctctctag gtctttgctt  139681 atcatcactc tgctcattct tcaagcctca cttgattact gcctcctctg tgttgctttc  139741 ctggatttcc tcagtaagac atagtttctc cctttcatac ttctgtggta ttaagtatgc  139801 accagttaca tgtgactcat ctccaagtgc tttggcatgg agatattatt tatgttcctt  139861 atatgactac tgaccacttt tttctagact aaatattgaa acacttggcc agataatttt  139921 gcttaatttt gagtttcctt ttatactttt taaaacaaat ttttgaaatt aaattacatt  139981 ttgttaggtt gcaaatctga aaaagtccaa ggatgaggtg agtttgttgt ggtcagttgg  140041 gtagttgcta aactcatagc tggtttgtgt ctgctgacca gcacattgtt agcctagaga  140101 aagtctacat ggggaaccag attatgatgc aagcgttgct tggagagccc ttgatcaaga  140161 gcaaaacagg ttggtagact cgagggatag ttcagctagg tctgatggaa cattccagtt  140221 ttgccaacag aaggaaaaac attggaaggg cttatcttcc ccaggatctg gatctgttcc  140281 actgggtaac atttaataag cactaacatg gtctcttctt tcacttgcca tttcctgtgc  140341 ttctttttcc aactactaca tctcctttga cacattttct ttttcttttt cttttttttt  140401 ttttgagata gagtcttgct ctgtcaccca ggctggagta cagtggtacg atcttagctc  140461 accgcaacct ccacctcccc ggtccaagcg attctcctgc ctcagcctcc tgaattgctg  140521 ggatcacaga tgtgcgccac cacactcagc aatttttttt ttttttttgt atttttagta  140581 gaggcagggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc aggtaatcca  140641 ctggcctcgg cgtcctagag tgctggcatt acaggtgtga gccactgtgc ctggcctctt  140701 tttaagtgta tcaataccat cattttggct gcttattctg ccctgggagc cattctgtct  140761 ctttaggaag tttttgcgtg tatcagatct catcttttat attttgatgt ttaatagcat  140821 ttaaaggatt ttgttttgtg ttttttaaat gatttgaaaa caagtgtgct cactaattaa  140881 taaacagcag attcaaactt ttgttgcttt ttcaagaaaa aaatgaaaaa ttctgtaaca  140941 atatatctta gccataaaac acttgtaatc agcactcctc cagaaatttc aggatgtaag  141001 ttatcttaat gattatacta gaaaatcttg gaaagcaggg atatggctaa ctttttataa  141061 catgtatccc tactgtcaca acaagagtta agacttaata aatacagtca tgtgttgctt  141121 aacaactggg atatattctt gtaaccaccc aaggggttca ttttgcctgc tacctggata  141181 cagccaattt atcaagaacc aggaattgca gtagagaaag ggtttaattc atacagagcc  141241 agctgaatgg gacactagag ttctattact gaagtcagtc tccctgaaaa ttcagagggt  141301 agggtttttc aaggatagtt tgaagggcca gggaatggtg ctgctgattg gttggagata  141361 caatcatagg gatgtggaaa atggtcctca tgcatttctc aagtccactc cttttcttag  141421 ttcctgctta gcggaggtgt tagaatttgc ttcttggtgg ggccacagga ctggttggtg  141481 ggtccaggtg gggccaccag ttgtcagaaa tgcaaaaacc tgaaaagaca tctcaaaaga  141541 ccaatcttag gttctgtaat agtgatgtta tttgcaggag taattgggga agttgcaaat  141601 cttgtggcta atttgttagt cctacaaagg cagcctagtc cccaggaaag aagggggttt  141661 atttaaggaa agggcbgtta tcatctttgt ttcaaagtta aactataaac taagttcctc  141721 ccaaagttag ttggacctgt ccccaggaat ggacaagggc agcttggagg ttagaaacaa  141781 gatggaatct gttagtttag atctctttca ctgtcataat tttgtcactg ttaacgtttg  141841 caaaggtggt ttcactgtag actttataaa caccatatac ttagactata ctaagtttat  141901 taaaaatatt tttctttctt tagtaacaaa ttaaccttag cttactataa gttttttact  141961 ttttgaagtt tttaattttt ttgaactttt gactcttgta ataacagcat aaaacacact  142021 ttgtacaact gtacaaacat attttcttta tatacttatt ctataagtgc tttctatttt  142081 cattttttcc ctttaaactt tttaatttaa atgaagacag aaacacaata ccctaggtct  142141 acacaggttc tggatcatca atatcattat ccaccacctc cacatcttgt cccactggaa  142201 gatcttcatg gacaataaca cgaagctctc gtctcctgtg ttaacaatgc cttcttctgg  142261 aatacctcct gaaagacctg cctgaggctg ttttatagtt aatttccttt tttacaagta  142321 gaaggagtac actctaaaat aacgattaag agtattgtac agtaaataaa tacagcagta  142381 acagagtcgg ttattatcat tatcaagtat tatgtactat acctaattgt gctacatttt  142441 tgtatgcctg gcagtgcagt aggtgtgttt caccaggatc accacaaaca tatgagtaat  142501 gtgttgatct atgacattac cagagctacc atgttgatat aaacaggaga cagggaaata  142561 ctgggtagaa gagggcagtt ccctggcaaa agccttactc ccaagcctgg aaacctgcag  142621 tcctaaatgg gaataggcat tcctgtttgt gcatccaaat gttgcctttt ggcctgccat  142681 gcccctctgt cctgtatcca tataaacccc aaatcccagg cttgatgagc agatgagcag  142741 acaaacagaa gagcagagga gcagaagagt ggtgctgcag agaaagagag aagagaagga  142801 gcatctgaat gtcaagagga gtttggatgg ggatggtcag agaggagatc agctgcagga  142861 cagccaaact ccaggggaag atcatctctc actccatccc ctttccagct ccccacccat  142921 cctgctgaga gccacctcca tcacccagta aaatcctcac attcaccatc cttcaagttc  142981 atgtgtgact tgattcttcc tggacactgg acaagaacct gggtaccaag agggcactga  143041 gctggttaac acttaagcca tctgcggatg gcggagctaa aagagcactg tagcacaccc  143101 actggggctt tgagagtcac aggcacacac ccctagatgc caccgtggga tgggaaccca  143161 aaagtgctcg ccctggctcc tgcacctatc tgtctacatg ctccctctcc tataacaggc  143221 ttgcacagca gtgactgcgc aacagatgag ccacacccct tccacatgtc tgcaaggggt  143281 atcagggaac tctccccttt caatgtcagt aggtaatagg aattttttag ctcctttata  143341 atcttatgat accacctttg tgtatgtggt ctgtcattga ctgaagtgtc gttatgtggt  143401 acgtgactgt atttattgag tggatggtca attgtatgag gtacttgaat aatgagtggt  143461 gtgaaccttg gttttatgac atcttctgag agctgctttc aggtgggtat aagaagagat  143521 atttctagtc taggtcccca ctccttttct tagttcctgc ttagtggagg tgttagaaaa  143581 aaaggttgga ctctggcact attttcctcc attggttata tggactcaaa gccataactt  143641 aaggaagaat gtctattttt agatttggtg actgatttag ataggttgct acagaaagtg  143701 gtacaaagat atttcacaca tagaatatca aatccagggt gctttagcac tgcattccaa  143761 tggcctggga tggatgggtg gaagccctgg caagctgaaa taaaccaggg caagctcctc  143821 tttggaattc acaagtctga caactggtga ctcaggctct agtcaggaga cctgaatgtt  143881 acgtctggca tcacgatacc ttagtttaca gagattaatc taacaggcct tcagttagtt  143941 tgctttattt taaaattctg cttagctttt tgttgcctac taaatttctc ctgatgtata  144001 tttagatgta ggtgaaggct gtagatgtat gcactaccaa caccagcttc tgggagggaa  144061 cattttccca ctcacaagca agtgaacttt gctttctcca tgaagaagaa tgacctgcat  144121 gatggctttc agaagtggag aacatggctc acagttccct ccacagttcc tccatggcct  144181 ttggttgcat cttctctgaa tggaggagct tgggttatgt gaaaagcaga gctaccagac  144241 tacataaatg ttttagtgag aaggcagcaa attaaaatat cagaaatttt gaaaggaaag  144301 gtttataata gttagattta aaacatactt tgaggccagg cagcgtggct tacgccagta  144361 atcccagcac tttgggaggc caaggcggga ggattgcttg agggcaggtg ttcgagacta  144421 gcctgcacta cataacaaga ccttgtcctg tctctattaa aaaaaaaaaa aggaaggaaa  144481 gggaagaaaa agtgctttaa tattcagagg catgagagat gcaatgagta atataggacc  144541 ttctctaagg acactggggg agcactctac agaggtggtt ctaatctagc ctggcaaatc  144601 tctgttccct tcatgccttg tacttccttc ttctttgtga ctttgctaat gttattcctt  144661 cctcttggac aaatttccta tactaaccaa aaggccccaa gacacagggg gaaatgtggt  144721 aaatctgaga ctggaaggaa attaccatct aatgtcactc ttgtacagta taactattgt  144781 taatattatt gcbggggtca ctcatttatt catatcacaa acactgactg agtgcctatt  144841 atttgccaag catgggcaat aaagagttga agaccaacaa agcccctgcc ttcccagaag  144901 cttatttgct tgtggggaaa ataaacagtg gatcaattaa caaataagta gataacataa  144961 tgtcacggcc aggcgtggtg gcctcatgct ggtaatccca gcactttgga agactgaggt  145021 gggaggatca cttaggccca ggagtttgag accagcctgg gcagcatagg gaaatcccat  145081 ctctaccaaa acaaaacaaa acaaaacaaa acaaaacaaa acaaacaata aacgaaacac  145141 atggtggcgt gtgcctgtag tcccagctac tcaggaggct gaggtgggag gatcacttga  145201 gcccaggaca cagaggttgc agtgagccaa catctcccca ctgcactcca gcccgggtga  145261 cagggtgaga ccctgtctca aaacaaacaa acaaacaaaa caaccaaaaa ccaaaaaaag  145321 taatgtcaga tggtgactgt tttgaggaaa ataaagcagg gtaggggaac tagtgataac  145381 tggtagattt gggtttctcc atctctggct gcttttgcat cctcagtaag gtgagagtgg  145441 caaaggaaat tccaggttga ctttcgggtt cagtgaattt tctaccccgt gtctcttcac  145501 tgccctttcc ctccccagaa cctctaaaat ctgatcctta gattctgcaa tgtaagtcag  145561 cttccttctt cctggttgcc agctcactac attcttattc ctggataaac caaaaatctc  145621 ttccttgttt tcatattttc aaaaagatgt agaaatctct cacctgctca tgttccttcc  145681 tttttgtctt gttggtatat atacctttta caattctttc actaccaaat gtagttggat  145741 attgggatgt agtcacaaca aacacataaa tacaattcac catttttaaa tggacttatt  145801 catttagtct gcttaaaatt gagataataa cacacgcacc agttgggttt ctctgagaac  145861 tctgggcatt tttaatcctg gcaattttta aattgcttag cagtaaaaca gtcagacaac  145921 agcacctatt gttataaatc cctgcctctt cttacctcaa tgaggctatc ctttctctct  145981 atcaattctg tcagcagaat taagaagagc cattgatttc cagtttgttc agcgtttttc  146041 ttcttaggat gggagtgatg acttctaacc tctttacatc tagagactca atttaagtct  146101 acttctttca ttcagccttc tctcttcatt ttcagctgcc tggaatgtct tctttctctc  146161 agttcctatc tttgacatta aaaatcacag tacttagtta tattctacct cacaccaatc  146221 attttacttg ttaatatctt ttttcctagt tagattgtga cattttggaa taaaagaaaa  146281 atatcctttt ttactttata gctctccaga tttcattaga ttagtataga ttcgagtgcc  146341 ttttatatat caggcaatgc ctagtgtata atatttttac ttatgggttt tagcatttaa  146401 cttatttaat gatcacaaca ttcctatgat gttatttgtt ttcataattt gttgaaatga  146461 aagctgatgg tcagaaaggt taaaaagttg tctggtcata atttttgagg aggcagagct  146521 aggttttgaa cgcaggtctg tctgattctg agaataatcc tgtgctcctt cagctgaacc  146581 acacagcccc tcttagtgct ttgtctccat agacactaag tgtattcttg ttgattgagt  146641 gaattaacga gtgaattatc tggagctctt tctgcttctg ttttcttctc tgtacaatga  146701 ggatcatcac atgaacctga tctaagaata gaatagtcca actgagttcc cttaatttgg  146761 taaccaagag agagtagagt taattaacta gaaccctttg ccatcacttc tctctaaact  146821 tttcatcatt ttcctctaaa agtccggtcc tgagctctat tacaagatag aacattttag  146881 cctctatcga agagagcact attaatattt tatggcattg gctccttttt tcctaatact  146941 gtgggattaa aataatgttt actaaattct ggatgttcga ttcctgtttt ttcatgatat  147001 tttataatcc aggccttctt catagagaca cagggctatg ttttataact gccagggtca  147061 agcaaagaac agcttgtgtg agatacttaa agaaatagct aagcagtaac ttcagacctt  147121 ctgtatattt tcctcaaaat tttctctcag tttttgtctc cctacaactc atttttagaa  147181 aacaaaaaca taacacaatt ttgccctttt aaaagataat acagcbgggt gcagtggctc  147241 acgcttgtaa tcccagcact ttgggaggct gaggtggggc agatcacctg aggtcaggag  147301 ttcaagacca gcctggccaa tatggtgaaa ccctgtctct actaaaaata caaaaattag  147361 ctgggtgagg tggcggcagg cgcctgtaat cccagatacc cgggaagctg aggcaggagg  147421 atcgcttgaa cctgggaggc ggaggtagca gtgagctgga attgcaccac tgcactccag  147481 cctgggcgaa agagtaagac tctatctaaa gaaaaaaaaa tgtactataa taatttacaa  147541 agtacagaaa atatctaaag gaaaagaaat aacatctcac aacctcatca tctagatatg  147601 actgcaaaaa ttttggcata tttcatttca gcttttaatt aatttatttt tgcagaagac  147661 atttatttca gatattctaa ctttataatc tgtagaattt taatgatatt tttgtatgac  147721 atctatcata aacatttctg catgtcattg aaatatttat aaatgttatt tttatttaaa  147781 caatgcataa ttgatataac ccttctctta aaattggtga tttcacatac ctggggatga  147841 gccgatgtga aacaaaagag aaagggtaag agatagctag tctcttgact catttttttt  147901 tttccatatg acttgaaaaa aagaacttat cttagagacc tctagaatag ttagcacaaa  147961 tagatttctc aatgtggtta agatgaaata cagatactga atttactctt ttatgtgaaa  148021 taaataaaaa ctggataaga tatatatagc aacagttttc aagacattat acctcagaca  148081 acaaaggata atgacctctg agagagggaa aacaaattag gtgagcctgt gattgcccca  148141 gtttactgcc tggagagaga ttccaggcca gggtgcagag agaagggttg cgaatggaaa  148201 ctattgctct ttctgagtta aggagagaga cctgaaagtc tgcaggtaca aagatagctg  148261 caattcatga gaaagagttc cagagaaaag aaaactgaac agagagtgag ctctggattt  148321 ctgtagtgtt cctgctgact cttctgctga atcatgatca gtgcatgtgt gtggctggag  148381 aaagaacctc tgaaaaggtt tagagggaca aatccttaga atcacatagg cctgggaata  148441 gctcctcttt ccaccagaaa gagtataaaa accatgaaat tcatgggaca ttaggtagag  148501 tacttagaag ggttttgctt cagcagtgag aaaaaattag tcctagacca aatgttgctc  148561 tgatcctaac aaaacttaaa aaatgagacc ctaaaggata aaactgtttc caggtaactt  148621 aaatatatac cagaacaaag ccgaagacta taggaatatg aaaatatcta gcagtcagta  148681 aggtaaaatt cataatgtct aatatgcaac caaatattac catgaatata aagaagcatg  148741 aaaataaata cccataattc caagaaaaat caattataca taattgcccc atcaatgaca  148801 cagatgatgt aattagtaaa caaagagcta attataactg ccaactctag ccattacaca  148861 tgttcaagtg gctagaggaa agatcaaatc acgacacaga agaaataaaa agacaataaa  148921 atatgtacag atgaaaatta caatatctga gatgaagcat aagcgagatg ggattcgcag  148981 cagattagat atagaagaag gattaatgaa catcaaaaca tgtatgacaa cagtagtata  149041 aagtctgtaa gaaaagaaat ggaaacatac tggtataagg ttttacacta tgtatgaaat  149101 ggtgtagtat cacttgaaga gagactgtga ctaaagacca ctgtaacctc ttagggaaag  149161 aaaaatatct ttttctaccc atcctgggtt cacagctgag gccactataa caaaaaacag  149221 attaataaca cagaagcata cacatttact taatataagt gttatgtgac acagtagcca  149281 tcataaggaa agaagactca aagaaacaga tctgagtatt tttatagtag gtttgatgaa  149341 gaatggatag tcatggagaa atataatggg gcatataata caatggggtt atgatctaat  149401 ggtagtaaac tgggggaaat ttagcbgggt ttgcttgttc agatttttct ccttgacctt  149461 ttgtcgtgag agacaaggat gtttcttttc tctgggtata gggagggcac ctctcacatg  149521 agggacttat gatctgcttc agagaagtgc cagggaagaa cagagtgacc gtcctgcttc  149581 tgcagttttc tcaaattcat acagcttaaa atatttaaca tgctaaggtg ttacattttg  149641 gggtagtata tcttgatacc catcacctga aaccaaccac tttataatag taacacaaag  149701 agttgtacat aatataccat aaaggtggta aaatggaatc attggaaaag tcaattcatc  149761 caaaagaagg ctgaaagagg aaagcaaaaa caaagaagag atgggagaaa taaaaattaa  149821 atggtaggga catgagcatc cattaatttt ggtatacagg aggggcttga ggggtgtcct  149881 ggaatcaatc cccctcagat accaaaggat gactgtatat tttttaaatt aagagacttt  149941 cattctttaa atattcttga cttacagttt tttaaaaaga aaaaaaatca aagcatagta  150001 tagttgttaa atcattttaa tagtatattc agtggctgaa atgacaggga gtatcaatca  150061 ttatttattc aatataaagt tatccttact gaaaaaataa gatataactg ggaaatatgc  150121 ttggatccct cacacatcca cttaatttct taaaggaaga aagatgaaac acatgtaaga  150181 acagaaacaa ataaaccatt tactgtaaca ttccaggaat tgtgggatcc ttttcttccc  150241 aagtttattt atttgcttat ctttatctcc tagtggtagt ttgtttcctt tggtagaata  150301 tatggcagtc ccacattggt gacacctggt gctcccttca tccaactgga tcactttgag  150361 attcagtttt acaccttttt agcattttct ttgtgttcat atatcagtta tgatgagcca  150421 ctgataatat tttgttctaa aacgaaacat attacttagt acttttttta ttgtctcgct  150481 gacttttaaa atttgagtga tgtacagact ttgttttttt aatgaaatat aaatattttc  150541 tcatggtttc taaattcctt ataaaattaa attaattcaa tctgcaaaaa tattaaatgg  150601 taagagaata aactcatcac ttagatgttc atattaaatg taaatggcct aaatacccca  150661 attaaaagtt aaaaatggtc taattgaata aaatacccat atccaactat atcttgccta  150721 taagaaaata ttgccacttg cagtataaaa atacaaatag gtaaaagata aaaggatgga  150781 aaaagacata ctattttaaa ctaataaaat attaattaat taattagtca gatttcagga  150841 cctttttctg aataattgat agaataaaca gacaaaaata tcagtaagga tacagaaaac  150901 ctccaaaata ttatcaatca ccttgaatta attaatattt atggggccag gcttggggct  150961 catgcctgta attccagcac tttggcaggc cttgagctca ggaattcgag acaagcctgg  151021 gcaacacaca cacacacaca cacacacaca cacacacaca cacgtgtata tatatatgca  151081 cacacacaca tcagctaaaa gcagcagaat acacattttc ttcaagagaa cacagaatat  151141 ttagcatgat atgctatatt ctaggccata aataaatctc aacagactta aaataattca  151201 gctaatacaa agtatattct gtaactacag tggaattaag tttgaaatta atagcaaaag  151261 atatctggca aatccccaaa tatttggtaa ctaatatcat acttctaaat gacccagggt  151321 caaataagaa atcaaaatag aaatttgaaa gtgtttgaac taaattaaac acacatttca  151381 aaacttttga gatgcaacaa cagcagtatt tagaggaaaa tttataatag tatagaccta  151441 tattagaaaa gaagatctca agccagtgat ctcagtttct acctgaagaa actagaaaaa  151501 caaaacaaat aaatccaaaa taagcagaag aaagtaagta ttaaagacca gagctgaaat  151561 caataaagta gaaaacagaa aaacaaaaca aaacaaaatt taataacacc caaaacttgt  151621 tattatacag atcagtaaga ttgataaacc actggtcaag actgattagg aatttatcaa  151681 gaagaaacga tttccttttt ttcatactgt atatgtagca cccaaaaata aataacttta  151741 gtataacatt tattcatcta atacagaaga cagaaatgag aaaagtggca tcattacaaa  151801 ttctacagat agtaaaagaa caataagata atatgataaa aaactcaggc caataaattt  151861 gacaacttag ataaattgca caaattactt atatgacaca atctaccaaa gttcattcag  151921 gaagaaattg ataatcttag tagctgtata tctattaaag aaattaagtt gatagttaaa  151981 aattatccta caaaacgtat tccaagctct gactgtttcc ctagagaatt gtacccaata  152041 tttaaggaga aagtaattct aattctgcgt aaacttttct aggaaattga agaggaggaa  152101 atatttccca actctccctg aggccagtgc tactctatcc aaaaccagaa aaagacattc  152161 caagaaaaca aaactacaga ccactgtatg caagaagcaa tcggaaatta aaaattgtaa  152221 aatatcattt aaaatatcag aaaaagtaat tatgaagtac ttaggaacaa acctgacaaa  152281 agtggctcaa gatttgaaca ctgaaaacta taaaacattg ctgtaagaaa ttaaagaggg  152341 cagaaataaa tggaaacctc atttgtgaat tagataaatt taacactgtg aagatattaa  152401 ttttccttaa attggtctat aattcaacag aatctcaatc aatacctcaa taggctttta  152461 aaaatgcttg caaaatttga caagctaatc ctaaaattta tatgaaaatg caaaggacct  152521 acaagaggca aactatcttt gaaaaagaag agtaagtttg gaagacatat acttgccctc  152581 agagctcatt ataaagctac agtaatcaag acagtgtgag actgaaataa agatagacaa  152641 agaaagacaa tttctaggtc atgagagtta tgtttcctaa aggaaggcag cagatgctta  152701 ttaactttcc ccgtgccctc aggatgcctt aaacagtggt tgccaaccac tagcagcttt  152761 agcaccactt ggaagctttt tagaaaagct aattactggg cccatcccag acctactgaa  152821 ccagaatctc tgtgggcaaa gcccaggaat ctgtgttttc acaagctctc caggtgataa  152881 tgatgtccat taaagtttga gatccattgc cttggccttt ccctgctaga aatcctccag  152941 gatttgggag acaggggaag aggtctggag agagtggcag aattcaacac cacagaatga  153001 agaggaaaat tgatggtctt tgtccatgga atccattaaa atatactctc attgctgcca  153061 ggctgagctg atgaataaaa aataagctaa tctcaaatca agccatcagg ctattgatga  153121 taattgtgtt ttagggtgag caaacagctt taccaagctc acacagttga gacaatttgt  153181 tgtttggaac tatcttactg taagatcctt aagaagaatg cagaagtatg aaaataaatc  153241 caggactcag aaatctttca actaaatctt taaaattctc tctctcatgc acacacacac  153301 atatgcacac atacacatat agtaagattt catgacacat gagacaggat gtgaagctga  153361 acagttcgat gaatgcctga gtggtaagat caccttgaag aaccagaagt gagggtctat  153421 tctagcbggg tatgagctac aaactcattt cttggggaac acatgaacac atcggggagg  153481 ctaagtagct tctgaggcta ctaatagaat ttcagtcatt tctcctgtca tctgaaaaat  153541 atatgatatt gaatttctaa aaatgggttt agtgtagtct agtcttactg tctaaaacta  153601 agatgtggct tattccaata accaaagtga ttccatccca tgtgagggaa aaaaaggata  153661 atggtgaatt aaaagcacct gcgtgtattt gttgctcctt tagaggagtc tctcttcatc  153721 aacgttaact ttctttccta cttttgatct ggctgctaaa agtctaggtt tagatctcaa  153781 accattgtcc ttctctgcat gatgtaatag ttacaattac agtctcaacc ctctggcatt  153841 taatgaagat gaaattgatt tctttagact gaaaacaaaa aaatcactta caatcaggat  153901 actgaatatg gtagcaagta caaggtccca gcttctagta gacttggcag actgtcaagc  153961 tcttactaag tgaccccacc ccatgccttt ttgtcttttc tgttgccaca caattacaat  154021 aatttgttct ctgaatgcca gagtactgac aaggaaagga attctgaagc tggctgagag  154081 aagtcgtgta aatctcccaa tctaggctcc attgactctt gtctctttct ttgtatggaa  154141 ctgattttat aatttctgtg gcaatgaaag actagtaccc aaaatgactg ctggtccttt  154201 gtttattgat caatctgagc atggactaga attcatcctc caattggtaa caagaaaaaa  154261 ttggatgggg aagcatacca ttggctaagg cagcacagca agtttgaatt tggctgcctc  154321 ttctttcaat attggttgac atcatcaaga gcagacattg gcgttggagt taagagtatc  154381 aagagagtta ataaatacca atttagggta atattttatg cctagtcttt atcttttggt  154441 gaagtggttt ctaatatcat ctcagactaa atcttatggg atatttctac ttgtagatgc  154501 taaggtatta agaaaaagct caaagtagtt gtgttttcct tatcttccta aaagtttaga  154561 ttaaagatgc caaaaatttg tgtgttggta tgtgtcaaag catttgaatg cccttgtaga  154621 ctattaaaac ctttgttctg taccaggcac tgtattgagt atattgcatg tatttattat  154681 tatatttagt tctcacagca accgtacaca ataattacaa ttccttcctt tcactaaggc  154741 atagggagtt taaataaatt agccacagta caggatggca taaaactgta gcagagccaa  154801 aactcaaaca tgtctctgtc tgactcaaaa acataggctc attctcctag agccaggcaa  154861 caacctgaaa gctcttgagt tgacttttct agttctgtgg atgaatgcaa tcatctcagg  154921 acccagataa acagaagtcc ttctttctta ttcgtatttc tcagtactag gccagtcagg  154981 acaaactctg ttctccatgg ccgtgatctt gaagaaattg agatttcatc caaaggaaat  155041 caggtattga aacgtgtgtt tatgtgtatt gattaatctt ctgcctgttt ctggaaacat  155101 ttgaagaaat ataacaaaaa gcaaatatcc tgaaactgcc taatgaacct gatctctctc  155161 tctgtctttc cctttctctc tcataggtct tttgcctgta tttctctggt ggaatttact  155221 aaataattat atcaggtgtc ttcttattgt acttgactgc tttcatcaag gtaatcttga  155281 ggacagagac ttcctttgtt agccagggca ctctagggga acagaaatta cacacacaca  155341 cacacacaca cacacacaca cacaggaact ggttcatgga ggctaaaaag tctcaaaatc  155401 tgcaggccaa aggcttgaga acccggagtc ctcattgtgt aagttccact cagagtctga  155461 agaggggaga agacagatgt cccagctcag agacctttag gcagagagag aaaattctgt  155521 cttgctcagc ctttggttct tttcaggcct ccagtggatt agatgaggct cacccacata  155581 ggggaaggag tctgatttcc tcagtctacc aatgcaaagg ttaatctcat tcagcaacat  155641 cctcacagac acacccagaa taatctttca ccaaatatct aggcactttg gcccagccaa  155701 atagacacat aaaattcact tccacacttt cttactaatc cgtgcattct ctccaataca  155761 gggcacccgg cctggcaagg agtaagtgct ccatatatat ttactaaatg acaagagatg  155821 agattatcct tagactatga ctcagatata gacaatcaat tattaatacc ctatcatttt  155881 tccccactct gacaacccaa actgaaaaat gttgggattg ccttttttga caatatgatt  155941 ttctctgaat gcagactcat gttttgacct tccctgtctg ttcctgttta gtattcatgc  156001 tggcttaact cattgattga tcaagtaacc attgagcatc tgccgtgtta acactctgaa  156061 caagatcctg taatatgaat ggtgtttagc ctgatgaata aagtgtggtg tctgtgcatt  156121 catttttata tatttattgt ttttaaccaa actttaccca tgtaaagaat aacattgatg  156181 gcaggaactt gaatttggat ctacgtacat gttccatttc agactcacca tgaaatgagg  156241 tgcttgcatt tttcattgct gattttacaa tacactttca caccttttgg gtaaaatttt  156301 gcaatcaatg taactgaggc agcatggtat gaaagcaacc ctggaggtgg aaatagaaga  156361 ctagaattta aatcttggtt atgccactta ttggttgtat gatttttgtc aagtcatttg  156421 acccgtgtct attcagagtt tctttgctag aatgaaggag ttaactagaa tttattgatc  156481 tcagtagtca gtctcctcag gcacagataa atcttggata tgtatcctga gatagctttc  156541 ccatttccac attgaagaca acattctatt ttagagcaaa aatgaattat attatttaag  156601 aatatgagtt tcagaattca gactcatgct tacgggtttg aattctagtt ctgccacttt  156661 cttactatgc agactttagc aagtcagtta atgtttgtga gcctcaggtt tctcaccagt  156721 aaagcagtgt gagtaataac tatcatatta tattattaca agcataaaat gaaataagag  156781 tacttggcac aaagaaggat cttaattttt agctttttaa aaaagctgta tttgtttata  156841 tgcagtatgt atatatatat tctcaattct attattatag actatattta ttatgttttt  156901 cataaagtca ttagtttcac tcaggaatta gttgaccctt gtgagataca tggtttgacc  156961 acttttcact ttgatgttct tcagaaaata agacaattag aaatctctga ttgtaatctt  157021 catgtaaaat attttacagt catggctaaa atgatcccag gagtggaatc atacacataa  157081 attcttttct ttattctaat aatgttacct ttagtgtcta tgccaagcaa gtatgttatg  157141 tgttgagata aaaattctta gtatgtttgt atgtgacatt cccaactccc atcccactga  157201 agtctatatt tacctagttt ctttcttttg ttttcctcta acattcatgc tattttaatc  157261 aatgttcttt cattttgaag cccccaataa gtttgacccc aaagactttc agtttgcccc  157321 tgctattcat aagcatactt atgacaatgc atgtctccca ttcttttctc atatttacac  157381 cgatcttttt attgggacaa atgggtttgt tttttcatgc ttgtgtttaa tatctcactg  157441 agttcagcat aagttattaa acataatttt ctgttttctc tttctccctc aagactttct  157501 ttttctctag acctttattt cctaactcca gagtatttgc ccaggtctat aggcccctct  157561 ctcttttgct ttcttaccaa cccatccacc ttcttctgtt tcctattgcc caactggctt  157621 cacttaaaca agagcatttg ttatttgtac agagtgcaac atataattgt cctactctgt  157681 ttggttgcta taacaaaata tcatagacta ggcagcttat aaacaacaga tatttatttc  157741 tcatagttct ggaggctgga aaatccaata tccaggcact actggcagat ttggtgtctg  157801 gtgagagcct acactctggt tcatagacag ccatccattt gcbgtgtctc catatggtag  157861 aaagaatgaa taaagtttct ggagtcttct ttacaatggc actaatccat tcatgaaggt  157921 ttcatcccat gacctaacaa taccattgta ttgggggtta tcttgcaaca tatgaatttt  157981 ggggaacata agctttcaat ctatagtaat gaagtaggaa attttccctg atcctttcat  158041 gggcaggaac tggagtatgc ctatttcaca gaggtcttat cagataaaaa aattctccat  158101 taaatggcaa aacaagtaac catttgggat tcctgggtgt acagtgccta ctattccaaa  158161 atgagattat tgaggctaac atgacccttt gtatacaaag acgggggcag aaataatatt  158221 tctagcaaat ccacacatct caatcacatt taatttcaca aaatttactt ctaataagca  158281 ttgttccaac taacaaacca tctggtgcta gtctaagata gagatggctg aagtgctcct  158341 gattccagta ttttaggtgt taaatctcca ttctaacatt gtcaatcctt aactggagta  158401 ctcaaatatt aactaacttc ctctaggata taaattaata tgtataccac attctatgtg  158461 aattatttta attatattac atgccatata caaattatat ataggtttag tcttcctgaa  158521 tattgcaagt tgagtctgtg agagaaaaaa ttaggatgaa ttgagaataa ctagaattca  158581 gaattctttt tcattaagtg ttgactgtgt taactcatat tcccggttag gtagcaagtc  158641 ctatgaagtg tgattttctc ctaacagcta aaaagcagaa aaaaaatgga tttattctag  158701 ttaatgactt gctttttcta tttttataga aaaaatgaag taaattattt cacttttctt  158761 gatgctatta ctattttgtc aggaagatag atcttctaaa ttttaggaaa ctatgaatct  158821 aagttctata ttgctctcat ttcctttttc tctttgtctc tcttctgttg tagcccctcc  158881 ctcaccgcta agccttcacc ctgactctac cctgccccca ctgccttttg ttctttggaa  158941 gacactcatt aacatttgct aatgtatgct aatgagcaat aattagcatc tctaatgtga  159001 acaaaagcag tgctacaaag gaagggtaaa gatgtgtaca gagttcagcc agccttttat  159061 gcttctttat gccttaggaa caatcctctt ctttcagttc tttcacaatt ctttagtgtt  159121 ttttgtttgt ttcattttgt ttgcttatcc atgaaccctg aaaaccattc ttcttcttga  159181 gttagaatat tgcaaaaatg ctacggagga cagaaagatt cctttttgtc ctaaataacc  159241 caaggatata agcacagctg ctaagaggtt ataatgcaca tttgtatttt catctggttg  159301 ttattttggt atcctattac tagaaaaggt tttaaccaga aaacctcaca caagataatg  159361 tatttcattt taccacactt atttacagtg gttgcccttt atggtggtaa ttgcaatgtg  159421 aaagcataca ctctgaatat atattatgac agcatggtta aataagaaat gttccctccc  159481 tcaaacaatc taaatgcaaa gaaaatgcaa gactcaccac ttactttttc ataaccacag  159541 agggctctaa atgtctttgt aaatagctat ttatttattg aatatgtata gttttttttt  159601 tgaaaaagcc agccctccaa accacataga gtaagagctg tttttgttct ttctgtagac  159661 tgatggtgtc gtgaaatacc taattgcagt ttctcacaaa tactccagca tgtaatttgc  159721 catttgcaga accaggcttc acatttcata tttgctcttc cagctcaggg gtggtagaat  159781 ttggaaacat accagcaacc cacttcactc agcctgtgtt taattataat ttcacgtaca  159841 ataaaagcag aaggaaaacg tgcaaaaaaa ttggtgtgca tccctttccc ctccttctta  159901 cgtatataaa aaagatttat ttccattgta aaaggataga atggggatct ttattttgag  159961 tagattttct atttttgttc tttctgtttg cctcagagtt agtgtcctct ctctgtgacc  160021 tcagagtaaa atgtgtttct ccataggctt catcctgttc tatttatcaa ctatattata  160081 tttatcaatt attttatatt gtgtttttaa taaagcagac atcagcagct atttattttc  160141 tacttctgag ggcctaaaga gtctcagaaa atgagtgtaa tctagaaggg aaaacattga  160201 agagtgacag ctattataac agttgtgatt tttgcctgcc tccctctttt ggattggtga  160261 gtcctaccaa aaaccaaaac tattattctc cttgtaattt tgaaaccaca gagattgaaa  160321 ataactattt agtatctcca agatattata atgtttgaaa atatgaccag ttttgggggc  160381 atttattaca aaagtttcca gtagggtgtt tttgaatgtc tgtgccctct ggttttcaca  160441 aaactggtct taaggaagat aagatactgg tacacacaga agaaatatca gcctacgtct  160501 gtctcattaa atcttatccc cagatacttt gatgatattt aagtgtaatg atctcattct  160561 gtgtttctca ctcctgataa ttttttaaat gtcttatagc ttacaggttt attaaggtat  160621 ttgatttatt taagaactac ataattattc tcttcattca atggcttctg aaatattatg  160681 tttaattcta tcatttgaag gacttgggat tgttataaac aaatggcacg agcttctttt  160741 tgtcctgacc tagaagtagc aaagataaag ggagctgctt agttaacctg agtgagattt  160801 aataatcttg ggtatatttt attctagagt aagaagaatt gcaccctatt acttttattc  160861 agttttgtat gcagtagctt ctgttgtcta cttcacaacc accaatagtg ttatcataaa  160921 ttcagagtgt tgggctgtat tagcccattc ttgcactgct ataaagaact acctgagaca  160981 gggtaacctg taaagaaaat aggtttaatt ggctcatggt tctgcaggct gtacagaaag  161041 catggctgct ttctgctctc cagcctcctc atggaggcct caggaaactt acaatcatgg  161101 cagaaggcaa agttgaggaa ggaggtacct cctacatggc cggagcagga ggaagagaga  161161 gaaggggaag gtgctacaca cttttaaaca agatcttgtg agaactcact attccaggaa  161221 cagcaaaggg aaagtctgcg cccatgatcc agtcacctcc caccaggcac ctcttccaac  161281 actggggatt acaattagac atgagatttt ggcacaaatt tgaaccatat cctgggccat  161341 tctctatatg gagatgatgc ctgaatatga tttggtgact cagtctagca tccaagtggc  161401 tcattgttgg gcaattcttc tttagtcttc tttagggcta attttactca ttccttttga  161461 aaattggatt gatttacttt ttgtttggtt ttaagaaagc aaaatatcta aatgctgttc  161521 ttggcatagc ttatatacat atacatgcat acacatgtgt aattttcttc agatcaaaat  161581 atgcatcccc atcattcgta ttgctataat cagaaattag taatttgagg ggcaactgaa  161641 tgaccttata cctagagttt tcagagtata atattacaca gtgtgtattc ataagaatgc  161701 tgccttttaa agaggttttt ttttaaaaaa atcatagctt attttttata gtttcactgg  161761 tctgtcctcc cttttctctc tttttttccc ccttgagaag agagatttca catttttgtt  161821 aaggggctca taatttcctt atgaaatatg acaaatttca ctttatctta aaagcaaaat  161881 attaatagta cagacagctg aaggtggtct gagttaacct gagttacaca ttttatatat  161941 atatatatat atatatatat atatatatat atatgttaaa aatatttatt tgtcatatgt  162001 agcaagacta aaatgcaaaa ttttgcttta tgcttattct tttccagtat catttactgt  162061 aattctcacc ccatatttat ttttttactt ctctttctgt ttctctcctt tctcctctca  162121 ttctttttct ttcttttctt ctccctaccc catcttttag ttccatactt ttgaattgct  162181 atagtggact caaatctaag caagaggtat attagtaagt tgttcagtct tttaacaaag  162241 tatcagtcag agaagcacag cccagggata aaccaaaagc agaaataaaa ctgaggaatt  162301 aataatctaa ttcgtgttgt tttctttaca ttataggtgg ttcatttcat agcctacatc  162361 ttcaatttct caattctcat tagatctttc ttaacagcat ataagaccat tctaaatagc  162421 aaaaatagct gtatcctttt actcactgcc catcagttca taaagccact tgaattcagc  162481 tttttgccca cacaactgca ctaaacatat gcctgccaag atcatcaata tctctacatt  162541 gtcaaatcca gtggtcaatt ttcagtccac attgtactta gcaacttatg atacgtctct  162601 gatgcacatc ttctgccatc cacaatctct gactttcctt ctacttaaga gctgattgtt  162661 catttttgat ttcttcagtt tgttcttctc ctgttcctca ccattttgag tctccttttt  162721 ctgttttgtt taccctcatt ttctttgtta tctcatctgg tcttatggct ttaaatacaa  162781 tgtttttgct gataattccc taattcatat ttccagtcca gacctttctt ctgaactcca  162841 ggctcaaata ttcaactgcc tacttaatgt catgcttgga tgtctagaca gcacctgaaa  162901 tccaacggat ctgattaaag tcctgatctt taacagctcc tacctaagct attctcccta  162961 cagtcttcca tcttcttttc ctgtaattcc attcttcagg tgctcaagca aagaacctgt  163021 tgctatcctt gatttctcta tttctctcac atcctacagg gatgacatgg gttcatttat  163081 gcctgtcatg ccactgatta acatccctat caagaaagtt tagtctgagg taaaaacatc  163141 caatttgtat gagaagggcc aacattgaca ttcttcgtac acaaaaaaga atcctgagaa  163201 gaaacacaaa agagctaaat aatacattgc tgttgcagct taggtaggct ggagaagaaa  163261 cccatacata atctcaaacc ttactgttat aaagtcattc tttttttttt tttttttttt  163321 ttttgagacg gagtcttgct ctttcgccca ggccagagtg cagtggcgct atctcagctc  163381 actgcaagct ccgcctcccg ggttcatacc attctcctgt ttcagcctcc cgagtagctg  163441 ggactacagg cgcccaccac cacacccgga taatttttta tatttttagt agagacgggg  163501 tttcactgtg ttagccagga tggtctcgat ctcctgacct catgatccac ccgccttggc  163561 catttttttt tttttttttt taagagggag tcttattctg tggcccaggc tggagagcag  163621 tggcacaatc tcggctcact gcaacctctg cctcccgggt tcaggtgatt ctcctgactc  163681 agcctcctga gtagcbggga ttacaggcgc ctgccaccaa gcccagctaa tttttgtgtt  163741 tgtagtagag gcggggtttc accttgctgt ccaggctggt cttaaactcc tgacctcaag  163801 tgattcatcc acctcagcct cccaaagtgc tgggattaca ggcgtgagcc actgcgcctg  163861 gcctataaag tcattctttt gcatcaaata gtaagactca ttaaaggcag tggtattttc  163921 ttttactgtc tacaaaccct tatccaagag cattttctct atattccttt gtgagcacac  163981 aataaatggt aattcaataa gtgaattttc agtttccaaa ataataacct ggagctataa  164041 acattgcttc aagaagtaaa tgtgggtcag agaaaaaggc aataccattc aactcttctg  164101 gccacttggt cactgtgtta tcctgaagaa gcataaacta ctttcagcat tatagattta  164161 aaaagaagcc ccagaacaac atccactttt ctgaacgact cctatgcctc tgaaatgtga  164221 cattttgctg ttgtttcttt ttactgtttt taattactga gtctatctgc atgaaatgag  164281 gatctgggtt gcctaggagt tcatctgctc ctattgcata ttcctctttt aactacacat  164341 acttcaatgc agttttgctt gctgcctcca acattttgac agacttcccc tcctcttcct  164401 tcactatcct cccatcactc tccaggagac aaggttattt ttaaagtgca tgatcaatgg  164461 gcattgggga gcagctgagg catgaagaga tcatacgatt gggaataagg tactagggac  164521 tgctgagaga aggaatggca acatgccatc tcagacattg tctgagaaag gaaagggttt  164581 gtagctccca ttcaagtatt ctgagctatc tcttcacaca ggtttttgtc ttggagggag  164641 ttcttaacat agttctttag cattgcttta agttgaagga gatataggcc agtgctgata  164701 gttacttttc aggccaaata atgttccatt aaaatcgagc ttgctctgag gatcttggta  164761 gtgtcttaaa tctcctggtc atagtgctgc tatttggttc ttgatgctta tgacaccttt  164821 gctgagggtt tgaatcaaga acaaaacaag tattatcaca atgactataa aacatgactg  164881 ttccacgatc agacaaagga atgcbgttaa gcaaagaagg cacctaagga gaatgtggag  164941 atgaccatgc acagaccaga atcactattg gaaaaccaac tcaagaggag ggactgggtc  165001 atttctgcag cagtcttcat tgcatcactg agaaattgca gctctgtttt agttctctac  165061 ttgccaccac agggaatatc ttcccttatg gacttttagg ttttatttaa tggttattta  165121 taaactattc cttctgtgcc ggagaagatg attcatgact ctagccctgc tttttctctc  165181 ccgtggttat tagaggaaac tgagttgttg cttatctctt tagcttggga taccttattc  165241 tgctcttttt atttaatata taatctttcc taaagatttc cttatatttt tgttcattta  165301 gtaggttttt ctgttttatt taattaactt tatattatca cattctagtg aaataatcat  165361 cacaaatcat cctaatacat cgtgcaaatg ttttaaaaat gtgctttggt tgtgcatatc  165421 gcaaagtagg ctgtgggtca gcatttgcta tttgtcctca gctgtttctt ctttatatat  165481 aactgataac accctgctcc aatgttaatc ttatatcatt aaaattcttt cctagagaat  165541 ccttctttga ctgaagaagc ttagtggtga cattaattgc aaataaaaga ccatgaccta  165601 ttgtagaatg tggaatatct ccttagaagt gtctgccttc attattgcaa actttcagta  165661 gtgacataaa gatctttgtc ctgtgtagtt tcagttgcag ccagcaacag aaggcatatg  165721 ttcactttga acaaaagaac atttattttc acattctgtg gctgatgttg agtgataaca  165781 tttttgcata tcctaaaatt ttttacccag atgcbgttta aaggcaaaaa gtgcttttac  165841 aataatattc tttgtgaatg gaatttacac tcttggcatg tgttgccttt tcaatatgcc  165901 catcaagttc tgaataataa cctttgacag tgagtgaaca gaaacaaaac cagaggttgt  165961 ttcatctgtt cacagcaaca ctgtttgtca tctttgcttt tttggaaaaa tgtcattcca  166021 ccttaaataa aaatatgata aaattcatgt tttataagca agttaataga cttcgattat  166081 taagaaatat tttaattttt ccaaggcaag aaacctgtga tgaatgaaca ttaagttgac  166141 aaaagaaaaa aatatgccaa taaatatatt ttttcatatt actgtagtgt caaaaatttt  166201 ataaaacttt tatatgcctt tataaaaatg aagcaaagct aagaagaaga tgctgtatgt  166261 gttatggggt gaggaataaa cagaaaaagt gtcctttgtc ttggaaagaa ctgtaaaatc  166321 acctatctcc atgttgccaa agggaatcac atattgggaa atttaggcta tattaatata  166381 atacgtataa aaataattga aatagaaaag atctggcttt aagcattttt ctaaagactt  166441 tttcatgctt ggtaaaagtg tttggaataa attattctct atttttaagt agttaatttg  166501 gttattaacc taattggtat gggcatgtgg atatagcttt attaacaatt caatttctca  166561 tgaaataaaa taacccgaca aaccccaagt ctacttattg caatacagaa tttattttgg  166621 ttgaagttat tttgaattga gctgatagct tataactttg aattgggctt ataactgtta  166681 tgttttgcaa atccctgaag attatgaaat agaaaaatct ttgcatggca ttgtataaga  166741 tgctgtagct gtatatcttt aataaatcgt gctcattttg gcaagtttat ggaaaaattg  166801 tattaactgc acaaaaacat tatgataaaa acaataaaag taaaaaccac ttactaacaa  166861 ttgtacaggc atttaaataa ttgctgtact gttttctttc ctcaacagta caaatcaaag  166921 tggaggaaaa agaagacgag actgaggaaa gctcaagtaa gtggtgatgg gccacttggg  166981 atacatttcc tatggaatac cagtaaactc aaagaattta tcctcttgtg gacttgagct  167041 accatatgta agcagaagtg tgtgtggata acttttcatg gtctcacagg aggaatcaag  167101 ttcagcaaac agaatcccca ctctagagtc tatccagttg gcactataag ggccaagact  167161 gtgttccctt gattgcttgc tgaaaaatca acaagcaaaa gacatgttaa taggagaaaa  167221 ggcatataat ttcatagaac ttgtattcat taaagcctta ggatgaagac ccaaagatag  167281 agaaaattgt ccatttttat gcttaggttc aacaaagtgt ggatagcagt gtagaaatat  167341 gattggacga aaagggtata atctaatgtt tacatagagt ggggaaacac aacaaggcct  167401 gtctgcctag attcttcttg gcctctctaa gcatgcattt ctttcttctg ggtatggggc  167461 agggaccctc tttggaatga gggtcttatg atctacactc aaacaaggta ggtcggatga  167521 tttcttgatg accagttttt acacagacag ggcagaggga atgttagagt agtattttta  167581 ggtttcatgc atttgagaag aatgtttatt ctgttgttat tgggtagaat gttctgtata  167641 tgtctgctag gtctgtttga tctataatgt tgttcatgac tgctgtttcc ttattgattt  167701 tctgtctaga tgttctatcc attatggaat gtaatgtagg gtattgaagt ttcctactat  167761 aattatattg ctgtatattt tctctcttga gtttggttaa tgtttatatt taggtgctct  167821 gatgttggat gcatatatac ttataattgt gatatcttcc tggtaaattg acccttttat  167881 tactatttaa tgcccttatt tgttgcttat gacagtttta tactaaaagc atattttgtc  167941 cgatgtaagt atagccaccc ctgttctttt ttagctacca tttgcatggc ctatcatttt  168001 ccgttccttc actttcaccc tatgtgtgtc cttaaatcta aagtgaatct tttatagtta  168061 gcatacagtt gtttcttttc tttggtttct tttttaattc attcagccac tttatgtctt  168121 ttgattgaga agttcaatcc acttaaattt aaagttatta ttgatagagc aagactaact  168181 tttgccattt tgttcattgt tttctgtctt aaagctcttt tgtccctttt ttatctcatg  168241 ttattctcct tcatatttta ttgattttta ttatagtgat atactttgat tcctttctct  168301 tttcttttgt gtgtcttcta tagaaatttt attgtggtta ccatgggact catgttcaac  168361 atcttataat tataaaagtc ctattttaag tagaaaacaa tttaacctca attgcatact  168421 aaaactctac acttctactt tccttgacac ttaatattat tgacatcttg agttacatat  168481 ttttatatta tgcatccatt aacgtatttt tatagttact gttaatactt ttttactttt  168541 ataatacaat taaaagttac caatatactg tcattaaagt attatagtat cctgtatttg  168601 tctacatatt tacctttacc agacagtttt atattttcat gtgattttgt gttgctcttt  168661 agtgtcctct cttttcaact tgaagaactt cctttagcat tacttgtaag aaaagtctag  168721 gggtgattaa cttaggtttt gtttgtctga gagtctttat ttctctgtca tttataaagg  168781 acaaacttgc tgagcatagc tttcttggtt ggcaggtttc ttctttccaa cacttttaaa  168841 atatcatcct actttcttct ggcctgcata atttctgcta agaaatgata gtcttatgaa  168901 ggtttccttg tacatgacaa gttgcttttc tgtttctttc aaaattctgt ctttgtcttt  168961 gacttctggc aatttaagta taatatgtat tggtgtggat ttatttgggt tcacataatt  169021 tagggtctgt gggcttcctg aatctgaggg tccattttct ttcccagatt tgggaagatt  169081 ttggttatta ttttctttga atagtctttc tggccttttc tttcttttat tctccttcag  169141 aactcccata gtgtatatat tggtctgctt gttgatccct cataaaactt tcttgacttt  169201 ttcttattct ttttatggtt ttgctcttct aactataatt tcaaacatcc tatttttcaa  169261 tttggtaatt ctttcttttg cttgatcgag tctgcbgtta gacctctgta gtgaatttct  169321 gttactctat tcttcagtta ttgtgttcag ttattgtctt gtactcttca atatttatct  169381 ctggttattt ttatattttt atttctgttg aaactcatac tttgttcatg catttttctt  169441 ctgaatttgt tgagcatctt tatgagttat ttttaatagt ctgttaagta attcatatat  169501 ctccattata ttagggctgg tttctggagc tttatcttct gttgtttggg gtatgttttc  169561 ctgtttcttt atttttcttg attttgtttg tttgttttgg tatccatata ttagaaaaaa  169621 cagattcctt tcccagcctt caggagaagg attagccttg tacaggagaa gagtttcacc  169681 aatgaggcag gccagagatt cttgggcctc tcaaacattt cctgtgtatg catcgtctct  169741 ggacttgtgt gtgtaaattc tcaataagag ggatttttca gttgactttt tctttttaag  169801 aattcataat ctcttgttcc ctccagtgtc cttctgtcat aacatgtgtc ttctgaggaa  169861 gcagcatgtc ctgagttctt ttttttgttt ccagtagtcc ccaggcatca acagtatgct  169921 gggtcctgtc catgccctga gactggtcat tcccttaggc agcctcctga gaagtctgaa  169981 cacagggtat atatttcagt cttttatttc ccatttcagg ggcaagtcaa gggctggaat  170041 tcttgccaac tgtgtcatgc tgaactgggg gaaggggctc tggtgaatga gtacaaacta  170101 attcaaaact tcacctttgt tctccatggc cctgggccat ttagaatatg ctgggtccta  170161 ttagtgctct aggagacaag tgggacagaa gccagtccag tcatttttta gaaaagttgg  170221 agtgttagat gcactatcca actgtttttc tccccagaga ggtgcagatt tggtgtttat  170281 catctggtta ttctgtgcta aattggggga gtggctattt gagtgaggca tactattcaa  170341 acggctatct ttgctctcat tggttcctaa ccagaggtct tttcctgtca gtgctcagat  170401 tctggcaaga cagaaaccag tcctttggga acctccagaa aaatcagaat gttgaacaca  170461 tggttcagtt gttttctccc ctccccaggg agagactggg agatgatggt tttctcccag  170521 ttgtatggta ttgtgttagc agagagggat tatggtgtga gggtgtgtca gatttttcta  170581 ccagctacct agctgatttt gtgttcatct agggttcagg cacctttcaa ctagtttccg  170641 aatttctcac gaagggagct tatctccaca ttgtagttga acttttatgt ccatggaggg  170701 aaggcgggtc cagggcttcc tattttgtca tcttgttgat gtcatcccag tagtttagtt  170761 ttaatacaaa aaatactaaa attcagagta ccaagtagct gcttgggttt gtgagttatt  170821 agtgggtaaa ttgtttcttg cctcctgtca agtttttgtc ctttctttaa ttagtgacta  170881 atgtggctaa taaaagcagg gtaaatattc agaatgccat gatggggttc aaataacata  170941 catttgccac aatattaaac aaacagaaac tcgttcttga tttggatgac agaatatata  171001 tacagttttc caagcccagt tagaaaagtt attatgggcc gggtgcgata cctcacacct  171061 gtaatcccag cactttggga ggccaaggca ggtgaatcac ttgaggccag gagttcacga  171121 ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaaaa ttagctgggt  171181 atgatggcgc acacctgtat tctcaactac tcaggaggct gagacaagag aatcgtttga  171241 actctggagc tggaggttgc agtgagccga gactgtgcta ttgtactcca gcttgggtga  171301 tagaacaaaa ttgtgtctca aaaaaaaaaa aaaagtgaag ttattctgtt ttttactctc  171361 tgctacctga catttagtaa tatatgtaat atttagatct tatacctgaa atatcaataa  171421 aaaagtttta acaagtggta attaaagata attttgaaaa aataaaatga tgactcacac  171481 gtatgtgaaa agaacatatt taactaataa aacaacttgt gagatgctat aatcagttca  171541 aaggaacgtc caaagaatag atacatttat agataataaa tattgaaatg attgtacaaa  171601 tgaaggcaaa gttgtttttg aaagggggct tgtctctcct ttggaaagag ttcatttgga  171661 tgtctacaga taaaaagtgt tttgtattgc tatatatggt tatgtataat tttcaaagtt  171721 gtcatatagt tctcataaaa tcagaatcag ataacacaga aaggtatgct gcagataatt  171781 catagttttc cattgaaata taattttttc tctggggtag cctctattta agagagtaat  171841 gataactgta atatttaatt ttttacagta gtttatgcta aatgttagaa gttaggagca  171901 atagaaatga aactggaata gtaatgttat gttataaact ttgtgaagga aattttatct  171961 taattatctt aatttatctt aattatctct ctattcttta cctggaagca tcctaaaaag  172021 ttatgaacac atgaggcatt cattgttgtt gatgatgaaa caaaataatg ctgtcattat  172081 tctcaatttt acattaaatt tatgttacct atttctattc ataagaaata aatgatcaag  172141 caaatgtgta tactactttt ttttttaaag aaaagaacaa aaatattgag gaaaaaggag  172201 aaaaatattt agaatcaaga atgaagaaaa tttaaattga gaggaacctc aagggttgaa  172261 tgaatttctc caaaattatt ctagtttgta gcacctcttt aacgttcctc ttctttgttc  172321 taagatagaa gtagtaataa atatgaagtg gttaatcact caacaattat gtaatggaat  172381 ggtaatctct aaacttggac ttatttgaat ggtcttagag gtcatggtat gatattaacc  172441 accaagctat ttagttactc aagtaaatga agaccagaac ttcttcaaaa acttattaaa  172501 atttgggaat ccacattcac ctatttgagt cggtgaacca caatggaaat ggaaatctag  172561 atacatttat ttaaatgatg ggctatgaaa tatgtattcc atgatgcatc ccatcacgat  172621 gtggagaatt gctagactgt gcbgtcagat gtgtaataat agttattaaa aactaagaat  172681 aagcttggta gtgggaggaa gcactttctg acattactca ttgaatcaag tgctatgttt  172741 aggtgaagag gaagaggagg tggaagataa gctacctcga agagagagct tgagaccaaa  172801 gaggaaacgg accagagatg ttatcaatga ggatgaccca gaacctgaac cagaggatga  172861 agaaacaagg aaggcaagag aaaaagagag gaggaggagg ctaaagagag gagcgtaagt  172921 tagttctgat attctttcaa aagttccaat gctgaagaag atcactcctt tcagatactc  172981 tttgacctta aaattggtaa ttaaagctac ttttagaaag agagccttaa tctgatgatg  173041 ctattttatt ctacttaatt aaatgtattt taatggttaa aatagaattt taaaatgaat  173101 atatattaaa aatggaccat gagaaattct cttatgaagg atctgaatta tcataggtcg  173161 ttgacatatt acagttaatt taaagatttt aaaatttccc cactaattgt atgcattgtt  173221 atctaggtta agtagaaact cctaaatagt gagcaaacat cactttatct tacagagcag  173281 gggttggaaa attatggcta aatccagccc aagaggtaag aatggttttt acagcttcaa  173341 agggtcatta ataaaaagca acaaatatgg gacagagttg tacatctcac tcaaagctta  173401 aaatattaac tatttggccc tttatagaaa gaaagtgtgc tagcccttgt tacagaggat  173461 ttgggttgtc attttctttt taatacaact caatatcttt tagttccacc aggaaaacat  173521 tttagtaaac gctgactttg tgtagaataa tgcattaaat gcbgtttagg aaaaatccaa  173581 gaaaatactt ttcttctttt tgctttttgg aaatttgcag atagcaggca ggtaggaaaa  173641 atgtacgtgt aaaacacctc taattaaaga gaaaacctag accccttgga aagaatgcaa  173701 gagaacagcc aacctgttcc acaactcaca ggtaataggg ccatgcgagt cgccatcagg  173761 tggtggaatc tcctccaaac actcctagga ctttgaagca tgaggaactt tctaagatgt  173821 cctcccaaga tgacacactt ctatactcaa tagctctaac tattgtgtta ttccttataa  173881 atgattgtca ttaaaaacaa ctgaatgaaa aatttgtcaa gtagagaagc ttagcattaa  173941 caaaaaatgg tttcttttag aataagaata acaccatcta cttcatgtct aagttttcct  174001 cctcctcttc cccagctttt cctttctccc ttttgaatac caagacaaaa cttgctttta  174061 aattttgact ctagtatttt ttatttatat ctgcttttaa agtttcttta tgctttattc  174121 ctttcaaaaa taaaatgcaa cacattttat gtcccatgta ttactatgat tgttagttcc  174181 attattatgt agtaatagtt cctatttagc aaagcttatg ctttccaaca gtggtatttc  174241 attgagaaaa catctccaat tgatgtatgc atgatatagg ttgtgttcca aaatttgctt  174301 ttcctctcta tttatgccgc aaaaaaatcc ttttaaaaag atgagttgga caggaattcc  174361 tctgctctct tcgtctgctg atggccctca tggcaactgc tcaacttcta ggaaatgggg  174421 ccatgtgaag caactggatc ctgtggctat gacagtgtct cttcctagct ggcctcactt  174481 tcattttgat cttgagaatc aagatccctt acctcccact cttccacata acccaactct  174541 ctccataggt tttgcaaatt gtatttttgc tgcgacaatt tgtgcatcta ttataaatag  174601 tatcagaaat tagttgtgat tattgatagt tctgttctct attttagagt ctattttcta  174661 ttgttcattt tgaagataaa catctttttt ttaaaagaaa atcttagata atatttttga  174721 gaaagattag tagccaaatc agggcacatt tatgtaggtt aattaattca gggtattttt  174781 tatttaacta ttcaagtaat gcctcaggga atttcccttg cattgacaca acatttgaaa  174841 ccaactaaaa ccaaggttgt aatgctaact atctttggag gcagttaaaa aaacactgcc  174901 ttgttagaca ttttggagta tttccagtaa tattacaggc ttttcctgac ccagttttaa  174961 gtggataagt aatatattca tagcagtgag aaattcagca tattatgcct tcttcttcct  175021 aacaactgtt gtttaaatat atcaaactta agatagaaaa ccattcttgc acagattagc  175081 ctgaaaattt agatgaggca tgcctatgcc ttttaatatg attagccctt tctttgagtg  175141 attctagaaa agcaggtttc ctgtaatgct gattagaaaa gtattttaat taccttcata  175201 tttgagggta acttatgtgt caacaactgt accctgtaac acagcctgat cctcctggtg  175261 aaataaacaa ttaacaacag agacttaaaa gatataccaa tctggggtca tttagtacag  175321 gaataaacgt ctttccatac cataataatc tcagaggtag ttgttatatt ttagtgtact  175381 ttgagcactg ggtttatgat gataaccctg agcaatccag aaaagttttg tatacatatg  175441 ttcattcaat aagttattta cccagctcta cttttgtgca acctaatttg cttatatctt  175501 tgggatactt ggatatgaac atgtaattgc ccacaatctt gcaatcttca aaagtccata  175561 atatagtaag ggataggcca cttagataca aattattatg acataagaaa gtatatgtgt  175621 cccagagaaa tacaaacaaa gtagcttgga gtctcagaga agtgaaaact gttctcacag  175681 ggatagttag aaaagggatt cttaaagaca tttcatatga tttttaaagg acttgaaatt  175741 tggacaagct gaacttataa actatttaat tagtattaga attgtttcta ttaaagggtc  175801 tctgaaagtt ggcctgtagg tttagttacc tggcaaatcc acacatcaaa tagataattc  175861 tttcattctt tggtgatgtt ggattagaga tgcbgtttta catgtgattc ttaatggaag  175921 ttcagtagtg taaagcttta aggtaattat atgtaaatat catgaattat tttgaaatgg  175981 ttggcaagtt aaaggcttaa catatcaagc aattaaatta ttaatcataa agattttttc  176041 taattgactt tattactgat aatttcttgc catctgtttt attttatttt tgctagtttc  176101 tgaaaatatt tcaataaaac tgctatctat gtaatttaaa gttattccta tgtttgcatg  176161 gaaacaattg tgatcatttt aattaaaaca catctttacc tcctaagaca aactaaccca  176221 catatcattc taattggcaa attaaaaaaa aaaattgtgg atatagatag agtaaaaaaa  176281 atcctgaaat attttatgcc atggctacac agcatcatag gcttttatat gataaacacc  176341 aaataatgaa aatagaaaca acccaatggc tatcagagat gtatcttaga agagtgtact  176401 tccctggttc tcttgaacca aaatgattat tctaagcaaa atgtttgaat tgtccaaaaa  176461 acaaactgtc aataggaagt gttattttaa agggttaata tgaatttttg tttcagtaat  176521 catagcatga ttaaaaacta taaattggtg gcaaataaag gagattgaaa gtcattttgt  176581 aaggtgaact ataaaactgt ggatatgtcc ttttcctcaa ctagaacttt aaaaagcagc  176641 ttttgcctta tttctactgt atctagtcat aaattatttt tctgagtaat actgaattgg  176701 attacaattt ttgttattgg tcaatatcta gtgaggggag aaacttcaac agttaattga  176761 acagagagaa tttaataagt gaattgttag gaggtataaa tgttaattag actgcagaaa  176821 aggtaaaaag agaacactaa agtatcatag tgacggtaac tactggaagc agctaccatc  176881 ccaagggctg gaggaacaat ggaaagggtt gaaacgaaaa cactgtagcg tagaggaaag  176941 accctaggag ctaaaactca ggcctctgca gaggggctga tgctctgtgg tgctggtttc  177001 tgtgggagag gtgatgaagc tggttctgct agtgttggta atattggtga taaggattca  177061 cttgcagtat ggcaaggacg ctcagctcca ggagtgaaga agagatgcta aggaggaagt  177121 gtcaccccac aaagcaaata tgaagcagag aggaagccac aggaaagacg gagaccctct  177181 tcagtatccc ctattgtcag agtatatatt gacccagcta acaaagcaga aatatgactc  177241 acaaaatacc agccccagca ccacaatatt aaagtgtagg agggtgtgtt tgaagttggg  177301 acaatagctt aaaaactgaa ataatctatt accaaaaagc tgatctctac aatgtggtat  177361 tgcatgcctc gatttaaaat tatgttgctc ttgtttagat tttgtttcct ttgagttctg  177421 gaccgcatag tgttttcgta atactaggaa cacagaaaag aaaagctaca tctcatgctc  177481 agtaggaact aaattccttt gaagatctct tcaaaggatt cacttccacc aaatatattt  177541 caaggtgaat tttaccaaat gaagttataa gtttaattaa cagataacat taagttacct  177601 ttgagaaata gatttttatt tttcccgatt tcaatttttc tttctttctt tctcttgaga  177661 cagggctaac aaaattttta agggcaaaga catcttcacc cctaatttat tatccttatt  177721 gagaaataaa atatttaaac gaaatgtaga attgagggaa ggtattcaag ggaacaaaga  177781 agagagggaa atatcttgat atatctgtaa ttattctttc cacagatttt ctggttcaga  177841 gagtttgagg ctctagacat aaaagaattg cttagggcgg gtgcggtggc tcacacctgt  177901 aatcccagca cattgggagg ccggggaggg tggatcacct gaggtcagaa gttcaagacc  177961 agcctggcca acgtggtgaa actctgtctc taataaaaat acaaaaatta gccgggcaag  178021 atggcagatg cctgtaatcc cagctactgg ggagcctgag gcaggagaat tgcttgaacc  178081 tgagaggtgg aggttgcagt gagccgagat tgtcccactg cactccagcc tgggcaacag  178141 aacgagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa gcccggctta tgcctgtaat  178201 cccagcactt tgggaggccg aggtgggcag atcacctgag gtcaggagtt cgagaccagc  178261 ctggccaaga tggtgaaacc cccatctcta ttaaaaatat aaaaattagc tgggctaggt  178321 ggtgggcgcc tgtaatccca gctactcggg aggctgaggt agattgcttg aacctgggag  178381 gcagaggttg cagtgagcca agatcgcacc attgcactac agcctgggtg acaagagcaa  178441 aactccatct caaaaaaaaa aaaagaaaag aaaagaaaaa aacagaatgg cttagattca  178501 gattcaggaa ggcaaacact actgcttaaa gttataatag ttccagtaat cctgcatcag  178561 tgttcagatt tgagttctca tgcttatggg tcctaatgtt gactgcatat ggttacattt  178621 aaaaaaaatg agctaaatat ctgatacctg ccttccttaa gttccaaagt caagcaaagc  178681 ttaactttat taaggtgttt cttttttact tttaaagaga agaagaagaa attgatgaag  178741 aggaattgga aagattgaag gcagagttag atgagaaaag acaaataatt gctactgtca  178801 aatgcaaacc atggaagatg gagaagaaaa ttgaagttct caagtatggt gccacttttt  178861 ataagtagaa acactttccc tgatattgat tttctaaatc ctctgaatat tccatatata  178921 tatatatata tatatatata tatacacaca cacacacaca tacacacaca cacacacaca  178981 tacactgtat atatagtata tgtaatacta tatatatcat ttatatatga ctcattatat  179041 ataatggtca cagtcataaa catgtatatc atatttctgc atatataccc aaatatatgt  179101 atatttacat atatctgttt cttatcacta gagagactgg gctaatgatt ataaattgga  179161 agcaactctg agaaattatt tagagtcttt taaattcttt ggtcatcttt aatcatttgt  179221 tccttaaact ggagtttcct tagcttaata catttgttac catctctttg aaagagataa  179281 tatatttgaa ttttacaagt ttgtgtggat tgtgcactct tgtttctctt cagggccctg  179341 gtctcaaatg aacttttcat gtgacagctt acattaaagc acagagaaga tgctaggcca  179401 acagaatagt aaataggatt ccaattaaag gttatgctaa tagctattcc ccgaacatgt  179461 cagtgaccca atttcagtct tatgttgatg ctaatgtgga cgcgaacgca gtcagagcac  179521 acagatttat aaactcttca tatgaaaagt caaatgatta tcctattctg ggggatggga  179581 agattcaccc ctgaggatca cactatattt ccctgccctg gtggttggga gaggaggaaa  179641 gggcagggaa aagggaaact gtttgtgata acagccatgt ttgcatctcc tagttttgcc  179701 aaagattgca ttcttccata aatcattttt ataaatagta gtaagtttta aaaactatcc  179761 cttcacaagc ctatttaact agtaatgctg taaaaatgat agtatagtat tattgtctct  179821 gatgatgaaa acaagaactg aaatagctat caggataatt cacttctagt cttggttctg  179881 caagagcttg tgtgctattt aaaggtatcg cttaatctcc tgaagcctta gttacctcat  179941 atccaaaata aagaaagata ttctatatct tctctgtgcg cttgaagcgt agccatcatt  180001 tatagtattt ttgttttgtt ttgtagagta aggttttcca agttctaaac aatggttttc  180061 ccagaaaact tttgcaacac cacaaaattg cagtctggga actccctttg catgctcatg  180121 tacacatcca tcataaatga aggcaaaggc aagcagcatc ctacgttcca cagagctaca  180181 aattttgtgt atgcatgctc atgtgtctgt acattaaaat aattttcatt tagcgaagtg  180241 ataatgatgc taaattatag gttttaaaaa tattcttacc tggcaaaata gaagtttggc  180301 aaccctatgt gggcctctca aatatatttg aaatattaat gacccataaa gtccccaaac  180361 ttgggaactt cagataacta tatatagaaa gtttaaaatt ggagcaatat tgtgaacttc  180421 caaaatatat gattgaataa aaattccaag gactaccttt cctttccaac tgcatggagg  180481 tgtagaaata cccccctggt ctttgcccgt atctctcgtg caggatcgtg gaggagacag  180541 cagcttcaga tttgagttag gatctcagat cttccattta atagctgtgc acatttgatc  180601 gagttgtgta gtctctctac acaactcagg ttccttatga aattgtacct tattgacaga  180661 gtttttggaa ttataaaatg agataattta tgtaaaacat gttgccagaa cttggcacat  180721 agcbgggaaa cctaagttgt agttattact tcatctcaga acagacttga tgcccaattc  180781 ctgaagggtg acaagagaga tggagagaat ttgggacctg gcaagtctag gtgggagcag  180841 acctagtcac aatcagaccc cagaagcctt gtgggatggt gacacattgg taccagtttg  180901 gataaacaat aagattttga ggatgcaaca gaaggaagta aggcatttga caatttagca  180961 aaatccagga ccagaccgtt ctcagatctt ctaaaacata gccatagttc tgtggcagat  181021 ttcaaggtct caggccttgg tctggagtcc aagagttaag caaattttag caatggggag  181081 agataggcat tagcattgga aagaaggaca atacgagccc ttagtacgaa agcagacact  181141 gacaataagg agaccgcacc tgactctaat ctagacatag gtttttttat ttggcccaca  181201 tgtgttttgt ttctttttct tttatttttt ttaaccgtgg caatatatac aatacaaaat  181261 tcaccatttt aaccatgaaa tcgattttct ttatcataat ttttttcaat atttttaaaa  181321 atttaaatta cttttttttt ctcgagacag ggtcttaact ctgttgccca tgctggagtg  181381 cagtggtgct atcttagctc actgcagcct caatctcctg ggagcaaggg atccttctgc  181441 ctcagtctac cacgtacctg ggactatatg tgcacactac catgtttggc taattttttc  181501 tttttgtgta gggatggggt cttactatgt cgcccaggct gatctcgaac tcctggcctc  181561 aagccatctt cctacctcag cctcccaaag tgctgagatt ataggcatga gccactgcac  181621 ccagcctcaa tcttttaaaa gtgggagtaa aatattcaga tgttcagctt ttcatgaaca  181681 agtggaagat ttggtcctac attcttccat cacagtaaca gctaggacta agcacctggc  181741 ctctattaat ggggcattcc tttttcaatt tgcaccattc tcaaacaatc catattactt  181801 gtttatgctg cttggctgga ccctgtagac attcagattt gctgcctcct accagtgcag  181861 ctggggaaca agctaggcat gttaccaaga cggtgattca gatcttcaaa gccaaagtca  181921 gctcacagaa tggaagcaca aatttagtcc cagaaaagaa acaactgtgg cttctcacat  181981 gtcagcaagg ctcacagtct ggtgatgatt ttccatggcc agaagtggtt tctgccttgt  182041 ggccgcacct atgggttcca gctggtgcca tggccggggc cagcctaatt cttttggttt  182101 cagtctccgt gatgaagttg ttggtactta agtgcctgac ttatctctct ttgaatgctc  182161 tattgagctt tttttgaatg ttctattgag cttctcccca ccagattcca actacattat  182221 tagaacaagt ggtcagtact tcacagaacg tgcaggtaaa tgtttctcta ccccaatgcc  182281 accaatgctt gggagtgagg cagctttccc tctacccttt atttctttca gagacatcta  182341 actttgagag cgtgtttcta aggattatgt tattaatatt ccccaaatta gcctgcatca  182401 tcgctcctgg ctaagtctgt gaaacccaag atactaagct cagtgtaact gaaagagatg  182461 ttttgatcac agctttgaat ctgtgcctgg gttcgaagcc ttcttgttct ggacttggag  182521 aaagttttga aacttctaaa agatatttta gacagtgtca gggttttaag atatatttta  182581 gagtaagcct caggaatggc aacttatggt tctgagggtg ttatgggaga ctcagagata  182641 gttcccacat ttttaaagag catctaccat taggaacccg agcacactca gggcttagga  182701 tcaaaagatg gttaatataa gtggttgcta cataggcagg cagctctagg aattggttgt  182761 gaatccatat taatcctcaa acatggctca ggagctagag ttcagcattt tcaagatagc  182821 agaattggct ctatacagct gaaaggaagc catctccttt tcatcatcac tgtggaaatt  182881 gtgattttca ttctatgttt tattgtatat caatacaatt tcacacattc ctgtagcctt  182941 aaacctactg aatgataatc tcttggtgga aaggcaggtg tgtctggccc agaccagaaa  183001 tgtatatttt tattttttga tctaaaaatt actgatatat agtcagaatg aaagctgctg  183061 ttttcaattc tgagagacag aaagctccac taaacagaat actcagctct acagatgatt  183121 tatacaatga ggaagagtgt gtgtagggag ttggaggggg gtaagggaaa cagtgtcata  183181 ttttccaatt atttgaaagt caatttctat attttattaa tcacatcatt taaaaatatc  183241 cattaatgag aatactaagt ataatctgtt tttaagctgt tcatgggttt aattcagagg  183301 ctgtatgact agatctttcc tacctataag aggtcgcagc acttacctga tagcagccac  183361 cacaagtgaa ataaaatacc caggtagaaa gtaacaggtc tacttattac ttgtcttgaa  183421 acctaagact tttaactgta tcagaacatt atatgtggta gattgaaagt gctcatgact  183481 aaacctaaat aagcaaccac cttattttgt tacagtagaa taggttttag actgaaaatt  183541 gagacttgga ctttgagcta agtgcttcct ataacttctc tttgaacctc catttattca  183601 tttataaaac agataaattg gattgtggac catggtcttc aaactgctat cctccaaagt  183661 caagcagttt ggtgaaatca aatcagggca aaggaggcag aggtcgcagg gagagctact  183721 gggccacaat gccggcttca aaaacagacc tatggtttct ctcttctaca cagtgtactt  183781 ccatataaag cattgattgg aagaaagaat gcttctgtgg ctattaaaat aaaaaacagt  183841 tttaaaaacc cacttagctg gatatttaaa gaaacttatt ttggagaagg gacagttcta  183901 acatttcatg agtctacaaa ttaggataca gaaacactcc aagtatactt ttgcagggaa  183961 ttggcttttg gatagacacc attttaaaat gatttatttt gataacaaaa atgtttattt  184021 agctattata ctgactactt taatttctga gctttgtagt accctgacct attgtttctg  184081 ggagttgtcc attggctggc taggcctggt gatttattaa tgagacaccc agtaaagcca  184141 ggaaagttat cctcagattt cattcacact taaacaggtg cttcaaactg tcagctggcc  184201 attaaggtaa cattcctcct tactcaatct cccttgatct tttcacactt cttttcattt  184261 gtttgtttgt tttttatttt gttttatttt ttagttggga gaatgaatac atttttagga  184321 aagtgaaaac agaccatggt tgatttcctc taatggagct gttgggaaaa ctttgggaaa  184381 actatttatt tggcttccat tctcaccctt tctctcctgt tttcttgtag cttaagattt  184441 tcacaggcaa gaatcatggt ttatacttta gtttttctct catctgtcat tgtgaaggaa  184501 taaaagatgc tatacaagag gacatttaag cgtgtgaaca cacccaccaa cataccctca  184561 aaccattctg gattattttc ttttttaaat tttatatttc cataagtttt tggggaacag  184621 gtggtatttg gttaaatgag taagttcttg gggaacaggt ggtatttggt tacatgagta  184681 agttcttctg tgatgattta ttagattttg gtgcacccat cacctgagca gtatacactg  184741 aacccaattt gtagtctttt atccctcatc ccaatcccac cctttcccca gagtccccaa  184801 agaccactgt atcattctta tgcatttccg tcctcatagc ttagcttcca cttacgaatg  184861 agaacatatg atatttggtt ttccattcct gaattacttc acttagaata atagtctcca  184921 gttgtatcca ggttgcbgtg aatgccaata tttctttctt tttctttttc tttctttctt  184981 tttttttttt ttgagatggg atcttgctct gtcacccagg ctgtagtgca gtggcgtgat  185041 ctcggctcac tgcaaccttt acctgccagg ttcaagcgat tttcctgcct cagcctcctg  185101 agtagcbggg attacaggca tgtgccacaa cacccagcta atttttgtat ttttagtaga  185161 gatggggttt tgccatgttg gccaggctgg tcttgaactc ctgacttcgg gtgatctgcc  185221 caccttggcc tcccaaagtg ctgggattac aggcgtaagc caccatgcca ggcccaaatg  185281 ccaatatttc actccttttt atggctgagt agtattccat catgtatata taccacaatt  185341 tctttatcca ttcattgact gatggacatt tggtctggat tcatatttct gcaattgtga  185401 attctgctgc tataaacatg catgtgtaag tatccttttt gtttaatgac ttcttttcct  185461 ctgggtagat accctgtagt gggattgctg ggtcaaatgg tagttctact tttagttctt  185521 taaggaatct ccaccctgtt ttccatattg gttgtactag tttacattcc caccagcagt  185581 gtagaagtgt tcccttttca ccacatccat gccaacatct attatttttt gatgttttga  185641 ttatggccat tcttgcaggt gtaaggtggt attacattgt ggttttgatt tccattttcc  185701 tgatcattag tgatgttgag cattttttca taagtttttt ggtcgtttgt atatcttctt  185761 ttgaaaattg tctattcatg accttagccc actttttgat aggactgttt gtatttttct  185821 tgctaatttg tttgagttct ttgtagattc tggatattag tctttgtcag atgtagagat  185881 tgtgaagacc ttctccctct ctgtgggttg tctgtttact ctgctgactg ttccctttgc  185941 tgtgcagaag ctctttagtt taattaagtc ccacttattt atctttgttt ttgttgcatt  186001 tgctttgggg ttcttggtca tgaagtcttt gcctaagcca atgtctagaa ggttttttct  186061 gatgttatct tccagaattt ttatagtttc aagtcttaga tttaagtcct tgatccattt  186121 tgagttgatt tttgtataag gtgagagatg aagatccagt tttattctcc tgcatgtggc  186181 tagccaatta tcccagcaac atttgttgaa tgaatagggt gtcttttccc cacattatgt  186241 ttttgtttgc tttgtcaaag atcagttggc tgtaagtatt tggatttatt tctgggttct  186301 ctattctatt ccattggtct atgtgcctat ttttatacca gtagcctgct gttttggtga  186361 ccatagcctt atagtatagt ttgaaggaag gtaattggat gcttccagat ttgttctttt  186421 tgcttagtct tgatttggct atgtggcctc ttttttggct ccatatgaat tttagaattt  186481 tttttctagt tctatgaaga atgatggtgg tattttgatg agaattgcat tgaatttgta  186541 gattacttta ggtagtatgg tcattttcac aatagtgatt ctacccaacc acattagcat  186601 ggatgtattt ccatttgttt gtgtcatctg tgatttattt cagccatgtt ttgtagtttt  186661 ccttgtagaa gtatttcacc tccttggtta ggtataatcc caagtacttt tttttttttc  186721 ctgtggctat tgtaaaaggg gttgaatagt tgatttgatt ctcagcttgg tcactgttgg  186781 taaacagcag agctactgat ttgtgtacat taattttgta tcctgaaact ttgctgaatt  186841 catttattag ttccaggagc tttttggagg agtcttcagg gttttctggg tatatgatca  186901 catcatcagc aaacagtgac agtttcacct ctttaccaat ctggatgccc tttatttctt  186961 tctcgtgtct gattggtctg gctagtacta tgttgaatag tagtgagagt gggcatcctc  187021 gtcttgttcc agttctcaga gggaatgctt tcaactattc cctgttcagt attatgttgg  187081 ctgtatgttt gtcatagatg gcttttatta cattgaggta cgtcccttgt atgccgattt  187141 tgctgagggt tttaatcaaa atgggatgct ggtttttgtc aaatgctttt tctgtgtcta  187201 tttttttttc gggggggtgg gtgtttaaga gcagaaagtt taataggcaa aagaaagaag  187261 agaaaaccac ccccatgcag agggaggggg atcctctctt gctgcatcta ttgagatgat  187321 catgtcattt ctgttttaat tctgtttatg tgttgtgtca catttattta caagtgtatg  187381 tcaaactatc cctgcatcca tggtatgaaa ttcacttgat catagtggat tatctttttg  187441 atatggtgtt ggatttggtt agctagtatt ttgttaagga tttttgcatc tatgttcatc  187501 agggatattg gtctgtggtt ttcttttttt gttttgttct ttcctggttt tggtattagg  187561 gtgatactgg tttcatagaa tgatttaggg agtactccct ctttctcttt cttgtggaat  187621 agtgtcaata ggattgaatg tctgatagaa ttcagcbgtg aatctgtctg gtcctggact  187681 tttttttgtt ggtaattttt aaattactat ttcaatttca ttgcttgtta ttggtctgtt  187741 cagggtttct aattctgatt ctagctaaat cctcctgatt taagctagga ggattgtatc  187801 tttgcaggaa tttattcatc tcttctaggt tttctagttt atgtgcataa aggtgttcat  187861 agtagccttg agtgatcttt tgtatttctg tggtgttggc tgtaatatct cctatttcat  187921 gtctaataga gcttatttgg atcttctctc ttctttgctt cattaatctt gctaatcgtc  187981 tatcaatttt atttatcttt tcgaagaacc agctttttgt tcaatttatc ttttgtattt  188041 ttgttgttgt ttcaatttca tttagttctg ctctgatctt tgttatttct tttcttctac  188101 tatttgggtt tggtttgttt ttctagttcc ttgaggtgtt accttaggtt gtctatttgt  188161 gctctttcag actttttggt gtaggcattt aatgctatga acttttagca ccacctttga  188221 tgtatcccag cagttttgat aggttgtgtc actattattg ttcagttcaa agaatttttt  188281 catttccatc ttgatttcat tgttgaccca acaatcattc aggagcatgt actttaattt  188341 ccatgtattt gcatggattg gaggatttct tttgatttcc aattttattc cactgtggtc  188401 taagagagta cttgatacaa tttcagtttt cttaaattta ttgaaacttg ttttctggcc  188461 tgtcatatgg tttatcttgg agaaagttcc atgcactgat gaatggaatg tatactctgt  188521 ggttgttggg tagaatattc tgtaaatatc tgttgggtcc atttgttcta ggtatagttt  188581 taatccattg tttctttgtt gactttctgt cttgatgacc tgtctagtgc tgtcagtgga  188641 gtattgaagt cccccactat tattgtgttg ctgtctatct catttctgag gtctagtagt  188701 aattgtttta taaatttggg agctccagtg ttaggtgcat atttatttag gattatgttt  188761 tcctgttgaa caaagccttt tatcatgatt tagtgtccct ctttgtattt tttaactgct  188821 gttgctttaa agtttgtttt gtctgatata agaatagcta ctcctggtca cttttggtgt  188881 ccatttgcat ggaatgtaat tttccaccct tttacctcaa ctttatgtga gtccttatgt  188941 gttagttgag tctcttgaag acagcagata cttagttggt gaatactttt tttttaaatt  189001 atactttaca ttctggggta catgtgtgga atgtgcaggt ttgttacata ggtatacaca  189061 tgccatggtg gtttgctgca cctgtcaacc cgtcatccac attgggtatt tctcctaatg  189121 ctgtccctcc cttagctccg catccccaaa caggccacag tgtgtgtaca tgtgttctca  189181 ttgttcaact cccacttatg agtgagaaca tgtggtgttt agttttctgt tcttgtgtta  189241 gtttgctgag aatgatggtt ttcagcttca tccgtgtccc tgcaaaagac attaactcat  189301 ccttttttat ggctgcatag tattccatgg tgtatatgtg ccacattttc tttatctagt  189361 ctatcattga tgggcatttg ggttggttcc aagtctttgc tattatgaat agtgctgcag  189421 taaacatacg tgtgcatgtg tctttacagt aaaatgattt ataatccttt gggtatatac  189481 ccagtaatgg gatggctggg tcaaatggta tttctagttt cagatccttg aggaattgcc  189541 acactgtctt ccacaatggt tgaactgctt tagactccca ccaacagtgt aaaagcattc  189601 ctatttctcc acatcctctc cagcacctgt tgtttcctga ctttttaatg atcaccattc  189661 taactggcgt gagatggtat ctcattgtgg ttttgatttg catttctcta ataaccagtg  189721 atgatgagcc tttttttcat atgttggttg gctgaataaa tgtcttcttt tgagaaatgt  189781 ctgttcatgt cctttgccca ctttttgatg gggttgtttg atatttcttg taaatttgtt  189841 taagttcttt gtagattctg gatattagcc ctttgtcaga tggatagatt gcaaatattt  189901 tctcccattc tgtagattgc ctgtccaatc tgataatagt ttcttttcct gtgcagaagc  189961 tcttcagtgt aattagatcc catttgtaaa ttttggcttt tgttgccatt gcttttggtg  190021 ttttagtcat gaagtctttg cccatgccta tgtcctgaat ggtattgcct aggttttctt  190081 ctagggtttt tacggtttta ggttttaggt ttaagtcttt aatacatctt gagttaattt  190141 ttgtataagg tgtaaggaag gaatccagtt tcagctttct gcatatggct agccagtttt  190201 cccaacacca tttattgaat agggaatcct ttccccattg tttgtttttg tcaggtttgt  190261 caaagatcag atggttgtag atgtatggcg ttatttctga ggcctctgtt ctgttccatt  190321 ggcctatata tctgttttgg taccagtacc atgcbgtttt tgctactgta gccttgtagt  190381 ataagtttga atcaggtagt gtgatgcctc cagctttgtt ctttatgctt aggattgtct  190441 tggctatgca ggatattttt tggttccata tgaaatgtaa agtagttttt ttcaagtctg  190501 tgaagaaagt caatggtagt ttgatgggga tagcattgaa cctacaaatt actttgggca  190561 gtatagccat tttcacgata ttgattcttc ctatccatga acatggaatg tttttccatg  190621 tttgtgtcct ctcttatttc cttgagcagt ggtttgtagt tctccttgaa gaggtccttc  190681 acatcccttg taagttagat tcctaggtat tttattcact ttgtagcaat tgtgaatggg  190741 agttcactca tgatttggct ctctgtttat ctgtttttga tgtataggaa tacttgtgat  190801 ttttgtacat tgattttgta tcctgagact ttgttgaagt tgctaatcag cttaaggaga  190861 ttttgggctg agacaatggg gttttctaaa tatataatca tgtcatctgc aaacagagac  190921 aatgtgactt cctcttttcc taactgaata ccctttattc ctttctcttg cctgattgcc  190981 ctggccagaa cttccaatac tatgttgaat aggagtggtg agagaagaca tccttgtctt  191041 atgcbggttt tcaaagggaa tgcttatgct tccagttttt gcccattcag tatgatattg  191101 gctgtggatt tgtcataaat agctcttatt attttgagat acattccttc aatacctagt  191161 ttattgagag tttttagcat gaagggctgt tgaattttgt tgaaggcctt ttctgcatct  191221 attgagataa tcatgtggtt tttgtgattg gttctgttta tgtgatggat tacatttatt  191281 gattcgcata tgttgaacca gccttgcatc cccaggatga agccagcttg atcatgttgg  191341 ataagctttt tgatatgcta ctggattcag tttgccagta ttttattgaa gatctttgca  191401 ttgatgttca tcagggatat tggcctgaaa ttttcttttt ttgttgtgtc tctgccaggt  191461 tttgctatta ggatgatgct ggcctcataa aataagttaa ggaggattcc ctctttttat  191521 attgtttgga atagtttcag aaggaatgat accagatcct tttagtactt ctggtggaat  191581 tcatctgtga atttgtctgg tcctggactt tttggttggt aggctattaa ttgctgcctc  191641 aatttcagaa cttgttattg gtctagtcag ggattcaact tcttcctggt tcagttttag  191701 gagggtgtat gtggctagaa acttatccat ttcttctaga ttttctagtt tatttgcata  191761 gaggtattta tagtattctc tgatggtagt ttgtatttct gtgggatcgg cggtgatata  191821 ccctttatca ttttttattg catctacttg atttttctct cttttcttct ttattagtct  191881 ggctagttgt tgatctttca aaaaagccag ctcctggatt cattgatttt tttttttttt  191941 gaagggcttt ttgtatctct gtctccttca gttctgctct gctcttagtt acttcttgcc  192001 ttctgttagc ttttaaattt ttttgctctt gcttctctag ttcttttaat tgtgatttta  192061 gggtgtcgat tttagatctt tctttctttc tcttgtgggc ttttagtgct ataaatttcc  192121 ctcaacatac tgctttcaat gtgtcccaga gattctggta cattgtttct ttgttctcat  192181 tggcttcaaa gaacatcttt atttgtgcct taatttcatt atttacccag tagtcattta  192241 ggaacaggtt gttcagtttc gatgtagttg tgaagttttg agtgagtttc ttaatcctga  192301 gttctaattt gattgcactg tggtctgaga gactgttatg atttccattc ttttgcattt  192361 gctgaggagt gttttacttc caattacgtg gtcaatttta gaataagtgc gatgtggtgc  192421 tgagaagagt gtatattctg tttatttcgg gtggagagtt ctttagatat ccattaggtc  192481 tgcttggccc agagctaagt ttaagtcctg gatatccttg ttaattttct gtctcgttga  192541 tctgtctaat attgacagtg gggtgttaaa gtctcatgct attattgtgt gagggtctaa  192601 gcctctttgt aggtctctaa ggacttgctt tatgaatctg ggtgctcctg tattgggtgc  192661 atatatattt aggatagtta gctcttcttg ttgcattgat ccctttacca ttatgtaatg  192721 ctcttctttg tctttttttg atgtttgttg gtttaaagtc tgttttgtcg gagactagga  192781 ttggaacctc tgcttttttt tgcbgtccat ttgcttggta aatattcctc catcccttta  192841 ttttgagcct atgtgtgtct ttgcacgtca gatgggtctc ctgaatacag cacaccaatg  192901 ggtcttgact cttaatccaa tttgccagtc tgtgtctttt aattggggca tttggcccat  192961 ttacatttaa ggttaatatt gttatgtgtg atttgatcct gccattatga tgctggatgg  193021 ttattttgct cattagttga tgcgatttct tcatagcgtt gatggtcttt acaatttagt  193081 atgtttttgc agcggcbggt actagttgtt cctttccatg tttagtgctt ccttcatgag  193141 ctcttgtaag gcaggcctgg tggtgacaaa atctctcagc atttccttgt ctgtaaagga  193201 ttttatttct ccttcactta tgaagcttag tttggctgga tatgaaattc tgggttgaaa  193261 attattttct ttaagaatgt tgaatattgg cactgtcttc tggcttgtag ggtttctgca  193321 gagagatcta ctgttagtct gatgggcttc cctttgtggg taacccaacc tttctctctg  193381 gctgccctta atattttttc tttcatttca accttggtaa atctgatgat tacatgtatt  193441 ggggttgctc ttcttgagca gtatctttgt ggtgttctct gtatttcctg aatttgaatg  193501 ttggcttgcc ttgctagctt ggggaagttc tcctggataa tatcctgaag aatgttttcc  193561 aacttggttc cattctcccc atcactttca ggtacaccaa tcaaacatag atttggtctt  193621 ttcacatgat cccatatttc ctggaggttt tgttcatttc ttttcactgt tttttatcta  193681 atcttgtctt cttgctttat atcattgaat tgatctccaa tctctgatag cctttcttct  193741 gcttgatcga ttcggctatt catactcgtg tatgtttcat gaagttctcg tgctgtgttt  193801 ttcagctcca tcaggtcatt tatgtcctct aaactggtta tttcagttag caatttgtct  193861 aacctttttt caaggttctt agcttctttt cattgggtta gaacatggtc ctttagctcg  193921 gaggagtttg ttattaccca ccttctaaag cctacttctg tcaattcgtc aaactcattc  193981 tccatccagt tttgttcgct tgctggcaag gagttgtgat cctttggagg agaagaggca  194041 ttctggtttt tggaatgttc agccttttcg cactggtttc tccccatctt cgtggattta  194101 tctacctttg gtctttgaag ttggtgacct tcggcbgggg tctctgagtg gtcctttttg  194161 ttgatgttga tactattcct ttctgtttgt tagttttcct tctaaccatc aggcccctct  194221 gctgcaggtc tgctggagtt tgctggaggt ccactccaga ccctgttcac ttgggtatca  194281 ccggcagagg ctgcagaaca gcaaagattg ctacctgttc cttcctctga aagctttgtc  194341 ccagagggac atccaccaga taccagccag agctctcctg tatgaggtgt ctgtcagccc  194401 ctactgggag gtgtttccca gtcagtatac ctgggggtga gggactcact tgaggagtca  194461 ctgtgtccct tatcagagct ggaacccagt gttgggaaat ctgctgctct cttcagagct  194521 gccacacagg gcbgtttaag tctgctgagg ttgcacccac aaactcccct tcccccaggt  194581 gctctgtccc aggaaggtgg gggttttacc tatgagtccc tgactggggc tgctggcttt  194641 ttttcagaga tgccctggcc acagaggagg gaatctagag aggcagtttg ggtgcagtgt  194701 ccttactgag ctgtggtgag cttcgtccag tttgaacttc ctggcaactt tgtgtacact  194761 gtgagggtaa aaccccctac tcaagcctca gcaatggcag acgtccctcc ccccaccaag  194821 ctcgagcatg ccagatcgag ctcagattgc tgtgctggca gcgagaattt caagccagtg  194881 gatcttagct tgctgggctc cgtgggagtg ggacccactg agccagacca cttggctccc  194941 tggcttcagc cccctttcca ggggcgtgaa tggttctgtc tcactgacat tccaggcacc  195001 actggggtat gaaaaaacaa ctcctgcggc tagctctgtg tctgcccaaa cggcagccca  195061 gttttgtgtt ggaaacccag caccagggcc ctggtggcgt gggaactgga gggaatctcc  195121 tggtctgcag gttgtgaaga ccatgggaaa agtgcagtat ctgggccggt gtatgtggta  195181 cagtccatag tggcttccct tggctaggag agggagttcc ctgatccctt gcacttcctg  195241 ggtgaggcaa cgccccaccc tactttggct tgccctcctt gggctgcatc cactgtccaa  195301 ccagtcccaa tgaaatgaac tgggtacctc agttggaaat gcagaaatca cccaccttct  195361 gcatcgatct tgctgagagc tgcagactgg agcbgttctt gttttgccat cttgccagca  195421 aatcggtgaa ttgttatgta ttctgcaatt ctatatcttt taagtggagc atttaggcca  195481 tctgcattca atgttagtat tgagatgtga ggtactattc tattcatcat actatctgtt  195541 gcctgaatac cttggttttt tatttattta cttatttatt gtatttttgt tttaatgggt  195601 cttgtgagac tcatgattta gagattctgt tttgatgtgt ttccatggtt cgtttcaata  195661 tttagagctc ctttcagcag ttcttatagt gctggcttgg tagtggcaaa ttctcttggc  195721 ctttgtctga aaaagactgt atctttcctt catttatgaa gcttaggata caaaactgtt  195781 ggctgataat tgttttgttt aaggaggata aaaataggac cccagtcccc tctagcctgt  195841 agggtttctg ctgagaaatc tgctgttact ctgatagatt ttcctttata ggctacctgg  195901 tgcttttgcc tcacagctct taagattttt ccctctgtct tgactttaga taacctgata  195961 actataggtt taggcaatga tctttttgca atgaatttcc caggtgttcg ttgaacttct  196021 tgtatttgga tgtctacatc tccagcaagg ctgaggaagt tttcctctat tattccccca  196081 aatatgtttt ccaaacttag atttctcttc ttccttaggg actccactta ttcttaggtt  196141 tggtcattta acataatccc aaacttcttg gaggctttat tcatttttta aaattctttt  196201 actttccagt acattttgca tttctctgtg ttctttactt cctgaagtag tgattgtttt  196261 atatttatgc tatctatttc actgaagatt tctcccctca tatcttgtat catatttttt  196321 tatttcctta agttggactt cacctttttc tggtgcctcc ttgattagct tactactcga  196381 ccttctgaat ttttttttct ggcaattcag ggatttcata ttggtttgga tccattgctg  196441 gtgagctatt gtgatttttt gatgatgtta aagaacatta ttttgtcata ttaccagaac  196501 tgtgtttctg gctccttctt atttgggtag gctatttcag aggaaagatc tgaagctcaa  196561 ggctgctgtt cagattcttt tgtcccatgg ggtgttccct tgatgtagta ctctccccct  196621 tttcttagga atgtggcttc ctgagagcca aactgtagtg attgttattt gtcttttgga  196681 tctagccacc cagtggagct actggtctct gggctggcac tgggggatgt ctgcacagag  196741 tcctgtgatg tgaaccatct ttaggtctct cagctgtgga taccagcatc tggtccagtg  196801 gaggtggcag aggagtaaaa cagactctgt gaggtgcctt agttgtagtt gtttaatgca  196861 ctagttttgt gctagttggc ctcctgccag gaggtggcgc tttcaagagt acgtcagctg  196921 tggtagtata ggggaggatc aggtggtggg tgggggccct agaactccca agaaaatatg  196981 aactttgtct ttagctacca gggtgggtag ggaaggacca tcaggtggga gcagggttag  197041 gtacgaatga cctcagactc tccttgtgtg gggcttgctg tggctgctgt ggggataggg  197101 gtgtggttct caggtcaatg gagttatgtt cccaggagga ttatggctgc ctctgctgtg  197161 tcatgcaggt tgtcaggaaa gtggagaaag ctgatagcct cacccagctc ccatgcaacc  197221 caaaaggctg gtctcattcc cactgtgccc cctccaacag cactgagatt gttttcaggc  197281 agtgggcaag tagggctgag aacttgcccc aggttaccag cctcctggtt gagaaagcaa  197341 gcggggcttt tgtgccacct ccctgcctgt caccggattc acatcctccc ccaagttctg  197401 gccaggaaac ttcacatttg gttggaatcg ttacagagtt cagctggagg tttccttctc  197461 cctgtggtct tttcccagtt cctctggcag ccctcctcaa ggactcctgt gagacaagtc  197521 agaaattgct tctctgggga cccggagaac ccacatggct tttcctgtgg cttcttctac  197581 ccttgtgttt cactcagctc tctaaattgt ctcagctcca ggtaaggtca aatctttctc  197641 ttgtgatctg gacctttagg ttccccagtg agtgtgtata ttcggggcag gggatgatct  197701 ccctttccca cttttgcagt ttgggcactc acagtatttg ggctgtctcc caagtcctgc  197761 aggagcaacc tgtttccttc aaatggtctg tggattctct tgactttccc agtatatttc  197821 tgcagcagtt cttggaacaa aagttcacaa tgcaagtctc cacattctat tctatccatc  197881 caagtggggg ctgcaattta gtcctgactc ctatctgcca ttttttccta gcagttcatt  197941 ctggattatt tttaaccaat aactcaacca aagcacaggc cttcagttct tgtactttac  198001 aggtatcttg agtatagcaa tttttcatct gcagaatgga gagtatatag gcaattaatg  198061 catctagatt ttgtccatca aaaggtaaca ttgacatccc atttttctgc tattttataa  198121 gttcatacca ggtgtcaagc attatgctgt gggcaagttt cttagtctct acatccttga  198181 gtctccttac tatgaatgga gataaaagta ctactgcata aagttattga gataattaaa  198241 taagctcata gatacaagca tgtaacatgg tacctagcat aataattttc tttatccctc  198301 ttaaccctcc ttcaaggtag gttttactat tttgacttta catataagga aactgaaact  198361 ctgagaggat aaataattgt cagacaatta ataagtgata gatccacaat ttaagcttgt  198421 tgtgtggaaa cttaccttgg tatgatggag gtctctaagt acactaccaa gcaagctctc  198481 ccagaagtca caaacctgaa gttcacatac caaattaaaa tgctcaaatc acatggctta  198541 gtaagcttat ttaaagcaca gtgagaagta aggggaaaga gatgggttat ggtaagacat  198601 gggataaagt agcaatatcg tgagatcatg ggcaacagga ccacacttct gtatcctgtg  198661 ttctgcagtg ttcgtgtgcc ctgtctctct catcctgctg atagtgtggc taaggggact  198721 gaggtcccaa tgggggccac ataataaaga ttacttgggc caatgatagg tacaagctcc  198781 attggaatga atgacacagg acaagtacgc ctgatcatag cagtagcttg tgattagcct  198841 gctgaaattg caggagttgt gtctgcattt cttggacaga gcagatgcaa gaggaacaaa  198901 ctggatgaca ccaatggctg gtcaagttag cagtgacagg tatctcagtc ccaaagtgtc  198961 aggataatga tttggtcttt tcatctcttt ctaactgtaa tgttcttgtt tgttcatcat  199021 atatattttt aaaaatttat tttctgtctt tctttggcag atattacagg ttactaattt  199081 acctgctatc tgtagtgaac acatcaaaca tgcctatgca tcatatgtac atgtttactt  199141 attagctata tttaacatat cctatgtgca ggaccagcta cataatttgc atgatgtaat  199201 gtaaaatgca aatggggggc cccttgttaa aaaatactta agaatttcta ttattaagaa  199261 ttttaagatg atgaaagaaa ccagaatatg ccagctctaa atatgcctca ttgacgtaaa  199321 tatttttgag ctgaagggaa ttaagaagca catgcagaaa agctctctgc ctcttctatt  199381 tgcctaaaag caggacagag aattacaaaa acaaaaggtc ttttatgttc ctcctcccct  199441 ttcctgccta aagacaagat gtaaattctc ctttacaacc tttaccagct gagagcctgc  199501 ttcagaaaaa tctgggaaca gacttgactc tttcccacag ttctctggcc tttggaagct  199561 tagggcbgtt ttcctctttg tcctgtcact tctctacaat gtattgatct tgttgaatac  199621 tttgtattag ctgggattct aagccacact gccttgagtt acttttcacc tgcgtgatgt  199681 tcatgtatta atagacttgt ttgtttttct cttgttaatc tgtcatttgt tacaggagac  199741 tgtctcaatt aaaaacttac gagggttcag aaaaattata atttcttccc aacaatgaca  199801 atagcagagc ataaaactaa gcacagggcc catgtgagta tggggtcctg taacagtgca  199861 ggtcacaggc ctatgaaatt gcccctgcct atgaatttca cctgactatt ccaagccaag  199921 agctacttat tatctatgct gaacatttct aatgatttcc atcttttcca atagcagaat  199981 tcagtggtct caaataattc agccaactca cattatagaa ctcaagtcta tgtaactcca  200041 agtcactgtt catgcactat agtcatggag ttctttttaa atacctgtca tccccatgtt  200101 caaacccttc aatgtctccc tagtaattaa caaaatttag tcaattttgc ctaaaaaata  200161 tcggtgagct ccacaacctg aattccaact tactttccaa agcaaactct cattaattac  200221 tgatgatgac catgaggttt tggagaggga caaaaccatc tccaaatgtt tttgagtgtc  200281 tcctgtgtat cgtgtcctgt actagatgtt ttacacatca actcatttaa tccttatgag  200341 aacattgaaa acaaagttat ccccatttta cagatgagaa aattgagatt gatagaggta  200401 aggtcacctt acacagttat taactgtgag ggtggattaa aatccagatt tctctgtctc  200461 taaaacctca ggctttttct actgtgccat actacttcta atttgaactg tattttccag  200521 tgaaatgaga ttaatcttcc ctatagacat gccaggtacc tgttatcact ttattctggt  200581 atccgctcca ttttttggca tcctatgctt cttccatgcc tgactttatc tcccgtttga  200641 gcctctttct ctgccaacgc ccatagaaat aaaattcaaa tgaattctct tgattattca  200701 tttggctctt ctgttaggca gcattgtgtt gcatttttaa aaattatatg taaatctcca  200761 tttcagaaga gattttgagc tcctcagggc acgaaacgta tcacatagct ctttattgtc  200821 tcaagtacta gcatagtgct ttgtatgcaa tatttaatta atattttctg tgtgggtgaa  200881 aatgttaatg tcttttttgt tggacattca tttccaaagc agaacaatta acatgactgg  200941 atgtttaaag ggtctggatg aataggtgag tgaaggacag aaatgtgctg gtaaaaagcc  201001 ctgatctata gtgcttgcca atttccgtgg tgtaaatact tccactatag ccaattttaa  201061 gctaccaaca gttagagcca actcacaaaa ttcttgaaaa tttcataatc agtggttttg  201121 tgtgagccag cataagtcag cttcggtatc tctttgaggg atttaataat gaactcaact  201181 aaggtaaaac tgatctggaa caactgaaag cagaggttaa agtaaaataa ctctgttatt  201241 taatctataa tcaactatga aatgcttgaa ttagagctgc ctgtgagaag gaaaaacaat  201301 gattccataa tgtgaaggct ccagacaaag gccaaaagtg catcaatgac ttcttatccc  201361 agttttttaa actaaaaaaa ctgctagcta aatgattttt gttttatatg acttttgttt  201421 tatatgactt ttgtttatat gactttcctc ccaaatctgt tagcatgcat agagtttcag  201481 tttttctttc atcttctcct cttctgctca tttctctctt tttaaatttt atcataaagt  201541 ggaacacttt ttattcaaga gaaatcaatt cttgattgag atcagaaatc tcttgccatt  201601 cacattagag ttgatctacc acaattgcct gcttcatcat tttcattcta ttggaataag  201661 tatttacagc tataaactat cctgcatctt acatatttct attaaacaag aacaatgtcc  201721 gtgacagttt tctgtctcag gatttatctt attaatattt attgtattgt tatgagtgct  201781 tagcaaatta ttgtggttaa ctttaccaat gcctttcaaa taatattttg aaattttccc  201841 tgaaaggata ttgagaaaag ccaaatgtaa aaattattgt tttttttcct tgggatttgc  201901 atgttttgaa aacgttctca attgttaggg aagtcagctg taaaacacag gctaaatata  201961 cttttgtcta ccaagaattc cctttacttg tctgtttcgt gatttgttta atctttctta  202021 gttatgcatg taccatttta ccatagttac ctggagatat tcttgtctct gccttagttt  202081 ggcaggcttt tcaagtggct cactgagcta ctgtttctat ttcttttaga aagttgtgga  202141 ggcatttatt actctcataa ctgcctcaaa atctcaagca catggcctag ttaaatcatc  202201 ttgaggttct gcccatatgg ttgcagaagg atattagtca ttggaaaaaa tgggtctaaa  202261 atgataatat tcaaagatgt tttccaatat tcttggcaat cttattcact aatttccacg  202321 gacatttaat tagcaagaat ttaaagaacc ttgttttagt ttcctgctgc tgtaatagaa  202381 tatcacagac tggataatat ataaagaaag gaaatttatt gggcttatgg ttctggaggc  202441 tgggaagtcc aagaggcatg acactggcac ctggcaaggg tcatccaatg gtggaaggca  202501 tcacatggtg agcaaggacg agagacaggg agaaatgggg ctgtatttat ctttttatca  202561 ggagcctact ctgtgatact agcccactct catggtaacc acattaatac attcatgagg  202621 atagagccct catggccgaa ttatctctta aaggtcccat ctcttactac tgttacaatg  202681 gcaattaagt ttccaataca taaactttag gagacatagt caaaccatag aaatcttaaa  202741 cttcaaataa acagggattt tttttagtag cacagtataa aatgataata ataaatatca  202801 gatataaaaa atttctgaag ttctttttag atagataaat catggttact attatcttct  202861 tagttacatt tcattgcacc ctattttctg tggtattatc agtcaacata ttatatatag  202921 taagacacat taaattttct gagcttgcca gggcatcctg tcccctaaca gtttttgata  202981 atgatttatc aaatgtgtac tctttagaat tttagcbgtc agtaacagtt gattttcaca  203041 acttttatta gactatccat gatgtttttt ggaaaggtag ttaaaaggat aaatacatta  203101 attatcataa aattatctag gaatgctttt aaatacattt gacataatac attaacacta  203161 aaaggaaagc aaatatgcac ctaataagca caaaataaga ttaatcagag aaatgtgtcc  203221 ttgctgtttt ggggaagagt tatccagatc tcaggtaagg tactttttgt ggagataacc  203281 ttctgtttta tgaagcttgt aacaagataa caatcaaggc atttttgtgg ccatgtttat  203341 gtatatgagc aagcaatggc aagtgagata ctagtttggg ggcttaaata agataaaagt  203401 agttaaactt tattaaaatg cacatattaa aataaatttt gaaatacatt gtattcaaat  203461 attgtattag ggttctctta gacaactcat aggatacccc cacacacaca ttttatgtgt  203521 gtatgtatat atatatatat atatatatat atatatatat atatatatgt atatacacac  203581 acacatgcgt acatatatat acaggagttt attaagtatt aacttacatg atcacaaggt  203641 tccacaacgg ctgtctgcaa gctgaggagc aaggagagcc agtcccaaaa tcaaaactga  203701 agaacttgga gtccgatatt cgagggcatg aagcatccag cacaggagaa agatgttgtc  203761 ggggaggcta ggccagtctc tcattttcag atttttctgc ttggtttata gtcactggca  203821 gctgattaga ttgtgcccac cagattaagg gtgcatctgc cttccccagc ccactgactc  203881 aaatgttaat ctctctctct ttttttttga gacggagtct ggctctgtcg cccaggctgg  203941 agtgcagtgg cacgatctcg gctaactgca agctctgcct cccgggttca agccattctc  204001 ctgcctcagc ctcccgagta cctgggacta caggtggccg ccaccatgcc cggctaattt  204061 tttgtatttt tagtagagac agggtttcac tgtgttagcc aggatggtct cgatctcctg  204121 acctcgtgat ccacccgcct cagcctccca aagtgctggg attacaggcg tgagccacca  204181 cgcccggcct caaatgttaa tctcttttgg cagtacccac acagacatgc ctaggattaa  204241 ttctttgtac ccctcaatcc aatcaagttg acactcagta ttaaccatca caaatatcat  204301 aacaaatcgt gtgaaaggag gaaaggggaa tagttttaca tttcaaatat aaggggtcca  204361 agattccctt ttatagttat aaaaattaga aatttttaaa tggtatgaat cacttatttc  204421 aaatagttgt atttatgatg cttttgtaat atatatgcat aagtttacct atatatttat  204481 atatgtgtgc atgtacatat aatgtataaa tacacaaagg cactcatatc tacataatga  204541 tacatgattc tttggatgaa ttaactttta cattttatgc atacactctt attgtgtttc  204601 ttgaccagtg cttggtcaca gggatcagga caagttagaa gggaggctat gggaggacac  204661 tgtaaaatat taacacaact taattctgca gaaaggccag ttcacatagg aagatggtgt  204721 cctctgaggg tgcacttacc caagctgtgt tccccaattg cttaggacag tcttccatgt  204781 ctaagtttgt catgtggcaa acaatcaaat ttacctggta gtcctagtga tttgcagagc  204841 tcactgaaat gccatcgttt aaaagcatca ttttaaattt attgtccact gatagatcaa  204901 aagatagaat accctattcc aagagaaaaa ctaaagactt ctattagaaa aatttaggtt  204961 tagcacttct aaatatcact atacaacatt ttgaaaaatg ttttgaaaaa acagttataa  205021 tgcttagaaa catttagaag aatataagca cacaggtatt gtgttgaaac acattaccta  205081 cactttcaat gcaggatgct tcttctcact atggggcagc actttgtgaa tttttctgtt  205141 tcacagtatt cagaattcat tagaacatgt ttgattagaa tgcacatgag gcaagcaaaa  205201 ttagcacagt ctgtctatca agccacgtag atggccttgc aaagagctga atgctagtat  205261 atctaagaat atgagattat atgtatgatt catggtggaa atgtctcctt tgttagataa  205321 attcctgcaa accaatgcct ggaatgccct ctctgcctac tcgaattcta ttagctcttt  205381 aacatccatt tgaattctta tctcatctac aatatcttca gcaactctga agcctccatt  205441 gtcctctccc ttttcacttc aaggcbgtct tgcattgtta tgtaactatt tcatgggcct  205501 agatctcatt tttcttaata aagtttaagc tgtagaaagg aattcatata tttccttgat  205561 ttcttttaaa cacttaacac attaagaaca taaaacatac ccagtaatta cttaaagaaa  205621 aaaaagacta agtaaaaggg acaatgaaag aataatagaa ataaaatgaa tttgtttatc  205681 agccagaatt ttgggtgggt cctcctcata gctatgtata gcaatctata atttcagtgc  205741 tatttctacc tacttctaat aaaaatattc ccacagtaaa ggggcaaggg gaaattccac  205801 cattttgcaa cattttggtg attagaattg ttgagatatg gttttagaca gagtttcctt  205861 cttattcttg ggctggtgat tttaagattc atttgtgtgt tttaggtcac attctcccca  205921 aatctcattt ttgctcaaca caagaacagt aagagtaagc tgggatgcct tagtgatatg  205981 gcctggaact ctgcagccta cataatacta tccctacctt caggtattag tgttgctaat  206041 aacatgctca actgattcat taaaacaaag gacaaaaaaa taaacaaaca taaaatcatt  206101 ttcatagagc ttaaagagac tatccagaga gacatttata aagttaccat tataaaatgc  206161 ttcacactaa aaaagaattc tttacaataa tttggttgta aattgtgtaa aattcttttt  206221 ccctccatca attttagatt tattggttgg agccttgtaa gtcagactga caaaagacag  206281 attaacaaga gaaaaacaag cagaagttta ttaccatgta tatccctctt attcatggga  206341 gatgagtaac tgaaagagga ggttagaact tgagctcaca tagcatctta acaaaagaac  206401 agtacatttt taaagaagtg acaagacaaa ggaaaaggac tttgagtttc taggatggca  206461 aatgatggga aagcaaatat atgggggaac taatggaaaa taaggactat ttagtaaagc  206521 ttgtcatgca gattcctctg gtgccctctc ttgactgata agtctggaat agtcttcagt  206581 gattaacttc tgtccttcca ggtaagaggg gaatgaaaat aataccttta tatatttatc  206641 tcctgctttt aggcaaaggg ggagagcaga gagcttttct tgtatctgct gcttcttgat  206701 tgctttcatc ttgaaataat ctttatacca tatttttggc acattttggc ataatatggc  206761 acataatcct gacatggcat attttggggt gccatattct gctaccctcc aaattgtctc  206821 tacccttcta ttatcttagc agataatagt acaacctccc aaattttggt ttccttctgt  206881 gaggaaaaca cagtttgtgc tgtgaccagt attgtagctc ctggggaaac ctgtgtggtc  206941 tcctctctct tctccctgct actgtaatac taacaaaaag aatgtttaaa ccataaattg  207001 aatcttaaag caatcaagta caaatcagag ttaggaaaag ttttaatcag caggtagaaa  207061 aaggatctag tgtgctttta tttttaaatt tttcattaat ccactaaagc ccagcttgtt  207121 atttttacct tgtttcatct aaaattaccc taagatgctg gcatgacctc tagggtgtga  207181 ctaaaatgtg tttgagtctt tatttgacat ttaagccagc catgaaaatt agcattggtt  207241 tagagctcca gggagcaaag aagtcatcct gagtctgaag aatttctgtg gctgtaactt  207301 ggaatttcat acaaatttga cctgtccaag acttgcttta attattcact aacaccagca  207361 tctggcttta acacatcttc atgagtatca tcagaactag agaaaaaaaa ttcccttaag  207421 aaatttttgt acataggtca ctctcatgtt tgttgctaat aaaaatttta gaggtcttag  207481 taatctaaaa aatatatatt ttacctgtaa agtggtacta tccaaaagga actataccaa  207541 aatacgtcag acataaaagt taagaggtta tgaaaatgta catgcaattc tctttttgct  207601 tgttcttagt ttatttactg cttgttttca gatagtcagg tagttactct ttagagatgt  207661 aaaataaagt atggacatga aaagtagtta tttaccaaag gcaattatca agtatcaaaa  207721 catgcagagt acttactgcc agttcaggga gacaacaaaa caattatata taatatagta  207781 gctttttagc ccaatcttcc aataattgct aggccaacat gctaaattta agagttcttt  207841 acctcttaaa tttagtagtc tcagtaaata aaatttgttt agttctgcag gggcagaaag  207901 atgtgatact ttgtccctat cataaggtca aggacaacac ttctctaatg aaagagggtt  207961 cacaagagaa aaacataaca catttcttta accaaagttt tatatgacat ggaagccttc  208021 agaatgaaga tttgaagacc caaggaaaaa ctgtccattt ttatgcttag attcaataaa  208081 gtgtgaacag ccatgtagaa gtgttattag acaaacaggg aattatctaa tagtaatgaa  208141 ctgagtgggg aaacccagca atacctgtcc agattcttct tggcctcact gttgtaacat  208201 ctcttcaccc tcctggctta tttggtatag ttccttttag acagtactac ttcatagata  208261 aaatatatat attttgatta caaagactac aatttttgtc agcaacaaac atgagagtgt  208321 ttcttcctcc cttgacctac tgttgaccaa gactaggtca tagaatttct ttatggccac  208381 cttctagaca gaaaggtaga gaaggttaga gtaataattc ttgtttttat ggccggcttt  208441 ggggaaaagg gggttttagt ttctacggcc tgccctgggg aaggggaatt ctgaattcta  208501 tggcbggttt tggggaagaa caaggggtga gaggtaggag agcaggagaa ggtcagagag  208561 accttggctc tgatgctgct actgaggcct tccagtgtcc tttagttcaa ggtgctcggc  208621 atgccaaagc agcacattca ggatatcatt ttctgagccc aacagttcca tattctgccc  208681 ccaacttgtt gcacattgga attgttcatg gacttacaaa aatattgatg ccatatccca  208741 gccctagaga ttgtgactta atttagctgt ccccaacctt tctgatacca gggaccagtg  208801 tcatggatga caatttttcc atatactggg gcbgggtgag gagatggttt caggatgatt  208861 caagtgcatt acatttattc tgcacattgt aatatataat gaaataatta tacaactcac  208921 cataatgtgg aatcagtggg agccctgagc ttgttttcct gcaactatac gatcccatct  208981 gggggtgatg ggacacagtg acagatcatc aggaattaga ttctcataag gagttcacaa  209041 cctagatctc tcgcatgtgc agttcacaat agggtttgca cccctatgaa aatctaatgt  209101 gactgctgat ctgacagcag gaggagctca ggtggtaata tgagttagca atgggtagtg  209161 gctgtaaata cagatgaagc ttcactcact cgcccaccac ttgcctgctg tgtggcctgg  209221 ttcctgacaa tcatctggtc ttctcactgg tattcatttg ttcaattagc atttgttgaa  209281 attcacatct atgccaggtg ctaaacccat atctgtgcca gtggccacga cctgacagtc  209341 atctggtctt ctcactgatg tccattcatt caattagcat atgttgaaat tcacatctat  209401 gccaggtgct atattaagta ctgggaaatt agtacaaaaa atatagacct tggagattcc  209461 agtgcaatgg taaaaatgga ctagaaagca acacactggg ataactactg cagaaaggtc  209521 agaggttaag tcacactacc tagggggtgg aggagattgt tggaaagaaa gaaaggatca  209581 ggaaaggttt tgtggagaag ctgtagtgtt ggcctaactc tagaactgaa gataaagaaa  209641 aggaagaaaa taggtgtagg agaagagaaa gggtatctta gagaaatgaa acagcatatg  209701 taaaagcctg gatgcattag aaatcaactt gcagccagcc tctcatctta tgttttctct  209761 aacttatctt gtatatcatt gttgaaacat ttttctcaca gcactgtatt acacccatca  209821 atttcctgct caaaaatact ctggatcctt actaataaca gaatgaattc tgcactgcag  209881 acgtgacatt agggcatgcc agatcctcct ctaaagcatt taaactgtcc tcttcattgt  209941 ctatctgaag accccaggta tgttttcatc tcttcatttt tgcttatatc attcccctgc  210001 accagaatgt ccctcctact cctttgacca tgtaactgaa tcctcccttt gttcagggtt  210061 ccttgatacc actccatctc tcatctcaat cttttagcat ttatgtttac ttttactatt  210121 cttgtttgtt ggtaattaga tggtgcccta aatatttatc tatatcttta ctttttaatg  210181 aaattgtaaa ttccttacag aaaagcatag gaccacattc ctttatctct ctttctgcat  210241 atggtacaat gccttaaaat aaacaaaatt tatttttatt actgataaca aaactgaatg  210301 acaataatat aatgagtttg gaaaatggag aaaccaagca tttgcataat tgcctagtct  210361 ttgatcattg atgcacacta cttttacata attataatga gagtatacaa attgttctgt  210421 attctgaaat tttacttgac attgtatcat caacatttgc tatgaaaaat aataaatatc  210481 agcbgggcaa ggtggctgac acctataatc ccagcacttt gagaggccaa ggtgggcgga  210541 tcacttgagg tcaggagttc gaaaacagcc tggccaaaag ggtgaaaccc tgtttctact  210601 aaaaatacac aaaaactagc tgggtgtagt ggcacaagcc tgtagtctta gctacttggg  210661 aggctgagac atgagaatct cttgaaccca ggaggcagag gttgatttga gccaagattg  210721 caccactgca ctccagcctg ggcagacaga gtgagtctct gtctcaaaaa aaaaaaaaaa  210781 aagataaata tctttggata ataactaaaa gcatcattta cctggtgtgc caggtactgc  210841 tttgcttaca ctgtttcaac ttttgtatgt atgtccttat tccaattcca tgaggtaaca  210901 ctggtgttat cctggggaaa ctgggagcac tgagctcaaa aagagtagag ctgtgctact  210961 tactaggtga ccttggatac ttattttact tagcgaatcc tcagtttcct tatctctgag  211021 atggggataa taatggttcc cacctttcaa gattttgagg ggatgaagtg agatgatgga  211081 cacgaatagt gcctggcaga tggccaacac tcagtgtgct ttagctcttg ctgccgtcac  211141 tgttgcbggt cccattttac aagtcaggaa actggatcaa aggcatttaa taactctccc  211201 caaatcacac acctggtgtg tgacagagcc aggattcaaa cccctgtccc aattatgaca  211261 tgagataggg atcacagaat ttaatacgat gttgtccaag tgtaacattt tacaatttag  211321 tgctacagag aacatgtgca gagttttgag agaaaacaca gttggatatc tacagattat  211381 cttctgcttg gagagaaaga gaaattgaga gagatagaga gagagagatt cccaggggcc  211441 cgagctctct acagcagcac agcatggctg ggtcagggct caggatagaa ttcctgactg  211501 cctcctccca ggcggtgtca taactggggc ttctgaagcc caacacctgg gccctctcct  211561 tgggtctcaa atggagggtt gaatcctctc atgctcactt actaacaaga acaattccca  211621 ctttcaatgg ggtaacagtc tgaggggaaa tgggctaggg ttttgcctgg aagtacctag  211681 ttatttctta actttgtagt ttggagattc agcataaaaa ctgaagtcag ccctgttagt  211741 agtattgctg cttatacagc cgtccaccct tatcagaggg gaataccttc caaggctccc  211801 cgtggattcc taaaaccaag gatactactg aacctgattg ctgtcaatca gaacatattc  211861 ctgtttatgt cttccaccac acatttaatg ccttttctat cttaactaac cacttatcac  211921 acactgtggc cataactttt gcagtttgaa gtacaacaga aaaactagca agaatttctt  211981 ttcccttctt cacaatttca ggaagagaag acgtcttacc atagatctta gcaacctcag  212041 catacttttt tttttctgcc ctcattaggt tgagaacttt cccttattca cttaaaggag  212101 gcactttgtg gcttctcttt ggcatatcca aattgccagc atcactaaac ttatgctttg  212161 ggggcattat taagtagaat aagggttact ggaacataag cattgtgata ctgtgacagt  212221 caatctgaga acccagaggg ctactaacag gaggagagtg cagactgtgt ggatttgctg  212281 aacaaaggga agattcactt cccaggctgg acagcacagg atggcatgag atttcatcat  212341 gctactcagg acagcacaca atttaaaact tatgaattgt ttatttctgg aattttccat  212401 taaatatttt tggactgcag ttgactactt gtaacaaact gtggaaggca aaactgcaga  212461 taagggggaa ctactgtaat agttactgct tatactgctc ttgctatttg ccatggacta  212521 agctaaacac attacataca ttattttcta taatggatgt gacaatccta cagagtagct  212581 actattatct ccattttaca gatgaagcaa ctgggcatct taaccattcc agctactgcc  212641 atcagcattt gccttaggaa aaaaatgtgt tttgaataat cacttccagt atttgggatg  212701 attttcaata attctaccag cctaactatg aagttatatt atctaggagg cctctagttc  212761 ttatttttaa tctttgtacc ttcgagtagc ttcttacctc tgtaactcac tcccacagta  212821 atatttcatg agaagccaga ttctctggac tattggttaa attcttttag atggcagtgt  212881 ttgttatgaa aagacttttc attcttctgg tcccttcact ggaaacagct agaaagtaca  212941 agttttgatt acagttgcct aaacaccagt tttgaaatgt ctttcatttg cttgagcaat  213001 aaatttgttg ctcaatcata ctatcaaatt gaaaacaaga ggaaaggaaa gtcaacctaa  213061 cctaacccaa aaggggaaca tgtttcctgg gatgagaatg tgtcaaaggc agcatagcat  213121 gacctaacac ttctgtgtaa tcgtggttgt atcatgtgtt atgggtaaat tatctattct  213181 gtaagttagt ccagtgtgtg cttcttcaac taactgtgaa agcattcttg aaagaccatg  213241 aaaccttatt attctaatta ccaacacaac ggattgataa atgaatgatg aggccaggta  213301 ttattgtcat taaatagacc tcgctcaatt atttatcaat gagtctgggg ttacagctca  213361 gagagctgtg catattgtag cacggtttgc ttcagctctg agacctgaag accagattac  213421 agtcttggca ggtggctttt gttgaatgca attcaagggg gtggtacaca tttgtttcag  213481 tcagacattt ggatggtttg aggccaacag atattcaaag tttatccaca aaagcctatt  213541 tcattttaac catgtagaaa aatctcttta atttattcag ataaatacaa atgagtagga  213601 gaatggatta gctgtagaaa atcatacatg taaagatgtt ttcttgcatc ttagtgttct  213661 aaagactgtt ctttattttc ttagattctg ctatctgtca tggacacttc actgttctgt  213721 attgatcaat gtttatcttc atatgagatt tgtttttgta tcttctttct aattgtacaa  213781 tgaaatatgt tttctggtta agaaatacgt tatcaaggag gatagaattg ggtgatacta  213841 gtttttttcc atcctgaaat catgccagct cattgcaaag gtcagccctc aaaatagtat  213901 taaggcatgc cctctccttg agtctctgat accttgcagc ccaatgtccc ttcttgaagg  213961 cctgtcacct gcaagagtac tttcttacat cctatgagca tcagatatgg gggaatgaag  214021 aatctcttct tgctaaacaa atattcttgg tccaccttct gccccctggc tttattttaa  214081 acccatcccc aacatatctg atgagttgag tctagtaatt ctgtcttcag tgggctatgg  214141 ggagcaggga ttagctaaaa tggcbgttca gggacctctt tggtataaaa cttggtgggg  214201 gtgctggcag ggatctctca gagaatgaag gaggggatag agcattagag aagaaaagaa  214261 attcatacct gagattatgt aatagataat agagtctgga ctttgtttaa aaaccagaat  214321 ctaagatata tatgttgagg ctagggcggg gtagtaattg aaagagaaat atgaaactat  214381 acctagcgtc aaggaaaact aacagtaatt gaagagacaa aaataaaact tgtttatatt  214441 gttcaaagga aaatgatatt tataacatct gacaaaaact ttattaatgc catgtagaca  214501 gggttttata ttattaactg agtttataat taattttgta ctgattttaa tttgactgtt  214561 accttggctt ccttctctgt ttcttaagtt ttgctagttt aatgttcacg agctcacaaa  214621 attaaaaatc ttggtagaaa tatggagtag ctatttcttt acatcctttt tagaacaaag  214681 ttgtgctttc gaattgacca cttatctaga aagtgatata aatctaataa gcaaaactgg  214741 atgtctttta aattatctgt taaataacta gagcagtgga gatgtcctga aagtgagcac  214801 tttattacat atgaaaaaca aattttaatt ttactactaa gaagaatttc catttctcta  214861 tttatatgtg ttcattattc tagagattaa tatgataact cctatgtata cttagttttg  214921 tgaatttcaa aattcttgat gccaaataac tgaagtatag taaattctgc cgtaacatga  214981 tgtatgggtt cctaaaaatc ccgacactat gcaaaattgg gcaataaaaa cacattttac  215041 taaaaaaatg gggataggca cacaatacct agaaatatca ctagtggcac attacaaaaa  215101 atatgggaat ttagtaacaa tgacagcaat attttacaca tgttaatggt taagaaattt  215161 acaataaata tggcagttta ctttgaaaaa gacctaacgt tccctgtgga agttggcctt  215221 caaaagggtg cagcttgtga gtttttgaga agtgttggga ggagagtcgt tgttgtccca  215281 gttgtgagca ggtggggctt ttctacctgt gtggggaagt gtggtagctg atggatatgg  215341 tatgtggatt ttgtgtattc ctacgctgct tggtttagct gggtgcagtt ttctgcattt  215401 acctggcgtt tcttgtggat agaatcacat ataagcaaat cccagacttg tgttgtgatc  215461 aaattgttcc gtaatatatc aatcatgtta gaacaaggtc acggtttcaa aaccggcatt  215521 gccgtagaat tgactgtgta ataatccctt caacacgttc acatctatga tcccaccttg  215581 ttcttgccac catcttagca agcaggggtg cgattgcctg accatttgtt tgttttctgg  215641 gaaatcttga cctattaaaa gccacacagt tactgaggaa acctgtgtca gaccttgcct  215701 aggtctgtgt gagtctgagt caggtttgct ttcctctgaa aaatcagaca ctcatgtatg  215761 tgggacaaag agcatcagaa acatgggcaa ggtcatagag acagatccca gagactggat  215821 tagaacccaa cttgcttgat tttctgctta gaggcttcag ttcaccattt tagaaagtgc  215881 ctgctggctg ccaccctccc tcctgtctta tcacctctaa aagacattgt taatgcttag  215941 acaggatgtg ttttcttcat tgcatggatc taaaaaccca gccatgagaa cttagttttt  216001 aatttttgcc attgctttat tggatatttt agaatgtgca aaaggtttta gaaattgttt  216061 ttcaactaat tttaccagca cagaggtcat gtcaaatgtc agggtgtttg acaacaaggc  216121 caatctagtc tatcaattga gtttcagaga agattaatga taaagggtgc aatcccaaag  216181 tctgggaatg actttgcttt caagcattaa ttattgtgga aaataaaatt attagatact  216241 cccttgtcta catctacccc aaactatgtc aatcagctct atttctagaa ggtttacatt  216301 tattaaacac tccctgtggt caatgcaatg gtcaatgcta tggaagttac aacaagacaa  216361 gatattgtgt ccgctatcag gaaactgatt tgggagttct gtttgatgac cgaagagagt  216421 ctttaccact gtgcctatat ttttatgcca gaatatgggt gggtgcacat gtacaggtga  216481 gtaatgaggc cccactccct agtattagtt aagttagcag gtgtgtgctg tttttttggt  216541 cactgtgtat tgcaaaattc tgagtttggc actgatacta aggaacatct tacagaaaaa  216601 attccccact gacccttctt ttttttttct ttttgaaaca gaatctcact ctgttgcccc  216661 aggctagaat gcagtggcac aatcacagct cactgcaacc tccgcctccc aggttcaagt  216721 gatcctcctg cctcagcttc cccagtagct gggactacag gtacacacca ccacgcctgg  216781 tcgatttttg tatttttagt agaggcaggg tttcaccatg ttggccaggg tggtctcgaa  216841 ctcctgacct caagtgatcc acccaccttg gcttcccaaa gtgctgggat tacaggtatg  216901 agccactgtg cctagccaga cccttcattt ttaaaagttg actttatatg ttaataggag  216961 tttaattata gtcatatgtt gaagggtctt ttctgtaaaa ccacatattc caggagccat  217021 ccaactgagg acagcattgc acttgtggaa ccacaatcca ggcttgggtt atctgtttct  217081 atcatgacag aggctactcc atcacttaaa ctatatgttc tgcagccccc gagagctgaa  217141 gacaagcctg gattgcctct atttgtaatt ttcttttttg taaatttttt tttggtaaat  217201 tgtttttcaa acaaacaaca aaaatgactg tcccagtcag ttcaagctga tagaacaaat  217261 ggccatagac cgggtggctt aaacaacagc catttatttc tcacagtgct agaggctgaa  217321 agtctaaaat cgaagtgcca gcatggtcgg gctctggcaa gggccttctc ccaggttgca  217381 gatggctggc tccttgtgtc ttcatgtagt ggaagcaggg ctagctagct ctctggccac  217441 tacttacaag ggcactaatt ccattcatga gggttctacc cccatggcca attacctcct  217501 aaatacccca cctccaaata ccatcatgtt ggagattaga tttcaacata cagattttga  217561 tagggacaaa aacattcagt ctataacaat gatcaaataa ggttacaaaa attatagtgt  217621 atgtagcatg cttgcattat gttttgatga attaatgttt tttattatgc ataccaaaga  217681 aactaatgca actgctgtaa atgtataaat atttgggagt aatgttaaag tttacattta  217741 aagccctttc taaatgtgag gccgaaagta ttccttttct ctctctttct cttctcaacc  217801 ccatttactt tacagaatga tttttctgtt ttaagtcata attgcttttt ttttacagga  217861 ttaagtacca ggtcattaag tgtgttctat gtcagtttga cctaacctct ctgccctttt  217921 cttttttcta aaggaattct ttaaaaagaa gaagaggaag tattttaaaa taaacatttg  217981 actgccagaa tgtgatgtaa acttcaggtt caattctaca cttgatagaa atgaaaagaa  218041 ctagtgttct ctattttgac atttagcatc aattcccttt cagtgattcc agctgattag  218101 taagtgagac taaaatatct tactcttcct ggtcagcatt taaaaattta aacatggatt  218161 gaaaatttct aggttatgaa atacagtcta ggttcacctg tgaaggatct agaagaaata  218221 agactgcaga cctggtaaat tcaaatgtcc actacttctg tattctagtc attgcaactc  218281 acctcctttt atcccttatg ttatttttat tttctcaggg aggcaaaaaa atttgtgagt  218341 gaaaatgaag gggctcttgg gaaaggaaaa ggaaaacggt ggtttgcatt taagatgatg  218401 atggccaagg taggtatttt tatagttgtc tggtttatgg catattgcct ctaagaagaa  218461 cactggttct tttctaaagg ggtgaaaaaa atcttacatt ttgtatatat aaaacacaaa  218521 tactcataca gtatatacac agtatatctg tggtattgaa atttacaggg gagatttaaa  218581 aaattgttct tagaagagtt aaaatgaaaa ataagtcaag aaatacagat ttatggcaaa  218641 agacttactt gtgtgacttt agcacttcca aatataaaag attgcatcct ttttcatttt  218701 cattctctgg aagtgaaggg gttctggtca agttgttttt ctcaaagtat ctgtatagtt  218761 tttttctacc aggaacatca actatacatt ggacagaaaa taagaaaaca ataaatgata  218821 tactgataca aatatagatt ttggggaaag acagaaaagc aactaacatt tatttaacac  218881 ttactatgtg ccaagcactg aattgaattc ttttataaag ttatatttaa ttcttacagt  218941 aaagtaggaa catagatatt attatctcct ctttacaaat gttataccaa ctgtaagcta  219001 aatgtattcc cataaagttt tgtgaataaa gttcatatat cctaactttc atatatatat  219061 atactcacat acaatagatt aattttgtct gtttctacag tttaaataaa ttgaatcata  219121 tagtatctat gcatttgttt ctggcttctt tgatgcaatg ttatgttcac aagatatatc  219181 cacgttgttg tgggagttat acttcatttt tattcatgtg ttgtagtcta ttgtataaag  219241 atgctgtgac aatgtattta cccattctat tgtagatgga catttgggct gtttctagtt  219301 atgagtaatc tttttttttt ttgttcattt ttaaaattaa ctcatacaca attacttgtc  219361 ttctggtttg ttgaaacaat aatgcagaca tttgctacaa caatgactgt taaaatggct  219421 ggccacaaaa tctccagcaa tacattaatc tgaagggcat tcttgatgaa gttgactaat  219481 tttgccattt tcatccacct tatagtattt caggacagcc agcttaacct tccttttctt  219541 atgcttattc ttctttggag tggtgtaaga cttcttcctt ttcttagcac caccatgaag  219601 tctcaacaca agatgaagag tagactcctt ttgaatgttg tacccagaca aagcacatcc  219661 atcttccagt ttcttgccaa caaagatcag tctttgctga tcagtagaaa ttcctgtctt  219721 atcctagatc ttggacttcg cattttctat tgtatccaag ggttcaaact ccagagtgat  219781 ggtctttccc ataagggttt ttaaagaaaa tctgtgtttt ggtggtggtt ccactgcaga  219841 aggcagatgg gaaaaaaagc gtgggtgatc ttttgaactt cagacttgtc tcatgctatt  219901 atttagacaa tagtgcctgt ccagctccca cttcatccca gcatttgcat acatgcaaaa  219961 ttctctgcca cattctcatt cttcctggtg gtcctcttga ctatggatga cccaacattg  220021 gagttaaata gaaagaaggc cttttgcaaa atgattttat gacttgttgt cttctctttc  220081 aattaagctg accaatctgc ctctaccaga atgcagtgtc tcatgtcata caacttacca  220141 tcttgtattg aactcaccta tttgtacaca gactatcctg gtagatcaga aggctttcaa  220201 gacaggacct ggaaataaaa gacagaaaat aaaatttatt ttgtttatta tttttattat  220261 ttattttatt taattattca tattgagtcc ttcatacaat gaaaactaat taaacacata  220321 ctctgttcca atcaccctat tatgtgctaa tcccctgctt tcttattgtg ttatataata  220381 aatagcbgtt tctgagaggc cagcatattt tccataaaac aggggatcga taaacatttt  220441 tttgttgaat taaattggtc tggggttagt ggagaacagg gaaacaagtg aaacctactg  220501 tttccccctt tgactagaaa gtagtatttg ctgccagaga gacatttcca agcttactgc  220561 attgtaatgt tttgaggtgg gggataaaca tcttgacaaa tcaagaggtt ggactttact  220621 tttgtatttg actttctttt cagaaatggg caaaattcct ccgtgatttt gagaacttca  220681 aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtaag tccttatcag  220741 atctcaggtg gagaaggttg tcttagagaa gtatctcata agcttatcag atgcctttgt  220801 cagtttctgg acttttggga agactagaaa caaacaaaca aacaaacaaa aaccaaatca  220861 acaaaaactt tgtttatgcc tgctttcgtc actgtgaaga tttgctagca cttaccaagg  220921 acaatactgg ggaccccact ctcgtgttct accttagtcc aaaacattac cattctaacc  220981 tggttttctc tcctatacag ggaagtcact attgtgcaca atgacattga atcatcttac  221041 ttggaaggca gagattttat tttggcaatg aacatgacat tgagaatata tactctcatg  221101 aatgttagac agtaatcaaa atgaacaatg ttttaacaag tgaagaagtc ttagtctggg  221161 cgcagtggtt cacgcctgta atcccagcac tttgggaggt tgaggtgtgc agatcacttg  221221 aggtcaggag ttcgagacca gcctggccag cgtggtgaat ccccgtctct actaaaagta  221281 caaaaggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg  221341 gcggatcacg aggtcaggag atcgagacca tcccggctaa aacggtgaaa ccccgtctct  221401 actaaaaata caaaaaatta gccgggcgta gtggcgggcg cctgtagtcc cagctacttg  221461 ggaggctgag gcaggagaat ggcgtgaacc caggaggcgg agcttgcagt gagccgagat  221521 cccgccactg cactccagcc tgggcgacag agcgagactc cgtctcacaa aaaaaaaaaa  221581 ataaaaaaaa taaaaaataa aaataaaagt acaaaaaatt agccaggcct ggtgcaaaag  221641 cctgtagtcc cagctactca ggaagctgaa gcaagagaat cacttgaacc cgagaggcgg  221701 aggttgcagt gagccgagat cacactactg cactccaacc tgggtgacac agccagactc  221761 tgtttcaaaa aaaaaaaaaa agaaagaaag aaagaaaaaa aacgaagtct taaaacctca  221821 ttttcaaatc tctgaagtag aataagcaat agtcatccag gagcttgcta tctgaatatt  221881 cacattgtgc ctttattttg tagaatattc ataggaagga aggaaggaag gaaggaagga  221941 gaatatagcc aatcaaaaac ctatttagtt tagtgcttta ggcttagaat aaggcaagta  222001 aacattttaa aatattgtaa ataaaaatag taaattgttt tttaaaataa taatctaaaa  222061 aaagggataa catttgaaac aattttgagc acaatctttc catattctgg tttctaacgg  222121 tttcaactag gatctgattt ccatccattc ctctctagat tggaggcagg ttttcctgct  222181 ggttaagtgt ggcgttgtat aattaaaatg gaggctccat agggagataa cacagctgat  222241 ggatagcttg ctgacatgat tgggcatgtt ttaggagtgg ctaaccctcg gttccctgtc  222301 tctcaatatc agatgggaat tattaagtgg caatgaatta aaatacatca gctcattaat  222361 tgtatcccct tccacacatt cccagtgcca tttctctctt gctttaattt cctccttaac  222421 acttaccgct atctaaaatg ctatatcttt aatttaattt tttgatgtaa tcttaattca  222481 ttttatgttc atttctccca atagatggga aatttagttt tgttcactcc tgcattccac  222541 ttggcactta ataaatatgt attgaataaa attacagaca aactcgctaa atgtctacca  222601 atctaggaaa aaaagaaagg aatttagata catcaaaaaa gagaagacat catggatttc  222661 ttaggtttca actgtacagc tcaaatgtgg taggttgaga ggcactgaaa aacaaaaggc  222721 catttggagc attacggtcc tgatacaata tatatagtaa gaactctgaa tttggtcttt  222781 gctttgctgc agattagctg tttgacttct agccagtcat ttaactcctc tggacctcag  222841 tctactaatt tataaaattg tagggctgag tcttgatcag ttgttagata aatcccaaga  222901 aatttgtaat taatgatagg taaatatata catttgaaaa ttatttttaa agcacactag  222961 agcaggttcc agcctatcct aatagtaata tcatgctcat ttgtgttcca ataggctata  223021 gccagtgaaa caaaaacaga cagaattatt tttattgcca gaaattgcat gcagcaagag  223081 ttacacatat gaccaccatc catcatgagt gtcacagtag aaaagacaga ttgagagcta  223141 tccaataata accttcagtt atctcctctc ttcttctctt cttctagtaa atttggaaag  223201 ccacgctgga aaattgaggc aaatgtagat tatttttctt tccatatata atttatgatt  223261 tgattagttt gtcatgactt cttcactgtt aatggtgctt tgtctcaact gtgaagaact  223321 gagctttatt ttttatttta tcaatattca ccacaccacc atttattgag taccaccatg  223381 agtcagatgc tctacaaaca ttgtttcatt taatcttcag tgttcctgca atgtgcacat  223441 taaccttcct attttatagt tgtgattaaa taactgtccc agaattagta gcagagctga  223501 aatataaggc aaaatctgtc tgggttcaaa acgtatgctt ttccatgtgt taggctgctt  223561 tctcctttag ggaaggtttt acatactttt tctttttaaa tatgttttgc accagttcat  223621 aaaaagtatt ctacgaggcc gatggcagga tgagtagtta tagattttct tgatcgttat  223681 caaggaatta tttttcattt tctcatgtat ttacttttta gtgagtgatt tatttaatta  223741 tatgttttgt attctatagg atgcttaatg tactgatttt aatgataacc atgaggcttt  223801 gggctatagt attagttgaa aaaatatgaa acctatgtaa gaatatatta ttagagcact  223861 ggattggact atcttataaa aagtacccta ctaaatatag gtaaagcatg tatctgtgat  223921 cacctttgaa actgaactta atgcaaaatg ggaagaaata ggacatgcaa tggattttct  223981 gagttgagga ctttttgacc cctaccacct ctgtagtttg gacaatctgt tgaaatctct  224041 ggttctgttt ccacatttgg ggctactaca atatctacaa catcttgggt ttaactagtc  224101 actatacaag atcatttcca gctcaacatt ctatgatgtg taagttacag tcagttttac  224161 atgtatatgt aggcatgtga aattcattaa tcatactttt gattgataaa tcctcaaaaa  224221 tttgaatgca aaacagattt atactaagag gggactatat aattgccttc tcaaattctt  224281 tttgaaataa agttggttaa gtgtgtaccc tacttataga atacatattt aattataaaa  224341 cggatataaa tgcttttctc ttaaataaat ggccatttaa tcttacaaaa ggttcagaag  224401 tatcattgta ttccatttcg acatcagaat catctaatat atatcttatt taatcctcag  224461 aataagcctg acattattga ttaactgagc aaatagtgga tgcctaacat gtttctaggc  224521 actattgcta ctgccaaaga cagcagagac tctaccctca ttgatcttac atccaaatgt  224581 gttaatgtat gtatgcttgg atggggaaga cagaatataa tataagcaaa taaataatga  224641 cggtaattgt ggattgtagt aagtggcatg gtcaaaagag gagcbgttgc cttccattcc  224701 caacagcctt tctaatccac ttttccccac tctctgctca gtatctagat aataccaaat  224761 aagtattttt aaaatgtggc taaaggagtc caaaattaac agcctttact gagttttccc  224821 aaagctctgt ccaataattt gcagaatcaa gagcgggacc caaattagag tctaaaattc  224881 atactgtttc catcttgatt ccagtaagac ctagatctct ttattagtgt gaagcggatt  224941 ctcacctgat gactcccaac tctgtttcac ttaaaaaata gatttgataa ttcctgccac  225001 agaggatact gtgacgttat gcatcacttg ggaatactgt ggggttttac tgtcacgtca  225061 gccttaaggg gatcatgcct aaaactcgat ggttgctcct gtggacacat cttattcatc  225121 tcattgaact gtgtattttt ctgaagcaac tgcatgtttg tacccccagg aaatataatc  225181 tatacccatt gtgatgccaa cattattatt aagaccataa attaaataat tgaatgtatt  225241 tctagcbggg gattacaaat ttttctcagg atcaaaatct actttttcct aatagtagat  225301 tgcatcatca aaattatagt ttcagaaacc tatttttttt cagacaggaa atagctttgg  225361 ataggcaagc caaagcacag ggcttaaacc ttatgtttcc ttgctgccct aaggattcta  225421 gaaaatacaa atcaaatttg tcacatttaa ttccctaccc ctaaatagtt cgaaaaaatt  225481 gtgcttcaca ttctagccta acatgatggt atttatattg tagtcacaca gcaggtcatt  225541 taattggtct tttcccattt agaaatactc atatttatct gcttgtctta ttacccatct  225601 attcaagagg aaatgatgtg ttatgacaga ctacaaatta ctttgcctta ataataaaca  225661 accagaaaga gagttgaaat tttaacttta atttgaaaga aacaagaata ttcaggaaca  225721 agaatatgct taagcataaa gcctcagttt aatacgtatc agagactctg ttttttggtt  225781 gttgttgttg tttgtttgtt tgtttgtttt ttgagacaga gtcttgctct gttgcccagg  225841 ctggagtgca gtggcgcaat ctcggctcac tgcaaacctc tgcctcctgg gttcaagtga  225901 ttctcctgac tcagcctcct gagtaggtgg gattacaggc tcctgccact atgcccagct  225961 aatttttgta tttttagtag agacggggtt tcaacatgtt gaccaggcag gtcttgaact  226021 cctgacctcg tgatccacct ggctcagcct cccaaagtgc tgggattaca ggagtgagcc  226081 accgtgcctg gctgagactc tgtttttata cattaataat ttactatgga agcagcattt  226141 atcagtctga ttaaagaaat aagaattggt cattatgggc atcaaatttg tgaatctgac  226201 tggctttagc tgattgatgg atattatcta tacctattgt ttcagaaaca catattcatt  226261 gcatgtttat tgtatatatc atagtcttaa gaaaattaat tgaactatgt tttacttaaa  226321 gggccatata gcagtgtggt taagagagat ctagatttgg agtcaaacac ctgtagctca  226381 agactgcctg gtttagaagc ctggcttcct tgtttactag ctatgtagcc tatagatcta  226441 agtctctgta aaatgggaaa acaatagttc ccatttcgta gggatttgat gatcattaaa  226501 taagttaata catatagatc aaattggtgt ttgaaacagt gattcactaa atgttaccta  226561 ttattaatca acttttgatt cagtcaacaa ctgtgttaaa gtttttgttt cctgattcat  226621 agtgggacta ataatactta acctcattaa gttctagtgg cagcataatg agttgatgct  226681 gataaagttc ttggaacaca taactgacca tcaagatata ctagctatta ttattattat  226741 tactcatttt gcttccttac actgagagat taagtatgtt aaaattgcta ttcttttcat  226801 ttatgctctt ttagtcacac taatcaggca tttcttttta gtgaacatca gttttagtta  226861 acaacatccg gtaggataga accactagat aaaagggata aagagggaag atttcttctt  226921 ttttgttttt gtgttgagac aggaaaaact ggagttttat gacaacttgt tgtttcattt  226981 tctctacttt aagatcttca tttgttttgt tactgtgttt tctcctctgc tattgatagg  227041 tctagtgtgg aagaaacttt gtcttctgga tttcttagtc tcttccacct gtgtctgggt  227101 ctttcctata atcgttctag ttttaatgaa atctattggc ctgcaattca ttttctttac  227161 acttaagatt ctgtaaagac tcaacctcca aataaaatag ttgtgaagcc actctcaaat  227221 ctgagaactg gagtttggaa gttttggact ctaaagtata tttcattatg atgcttaagc  227281 atgttggagg aggggatact ttctgaaaca tcttaattca cttctgtctt ttgcatttaa  227341 gtatatttgt accctacacg caagaaattc atttgtcagg gattgtgtgt aggtgctgag  227401 aggatgggcc gtggcaataa ttagaaaaac aaaagcataa aaagtgagga aggaagaaag  227461 gaatggtggg ttagtatcct atatgcggga tttcatactg gaagatctta catgcgattc  227521 cagggaaaaa cttacattga tacctagtga ccaaggcttt cctccagtaa atgagtaact  227581 gtaatgagta acaaactgta agtccactgc cttcaataaa acatgatgag tgaacctggc  227641 tgagcagccc tcaggtagtc gttaccagag aatgtagata acggccatga aatggtatga  227701 agtcactggg agccaagtgg gtgatcagat gtcctaggag aagcagacca gtgcacctgg  227761 tgacagtgct gggctgggct gaggtagggt ggggtggggt tgtgtatcaa aaccacacac  227821 ccttagaaac cttatagaac tctgcacccc tcggcaatgt gaaatcaatc caaattctct  227881 tgtgagcata aagaaaaata ttgacttcaa aatcattgat tttttccaaa atatccattt  227941 aaagattgac ttcttaagtt tctaaaaaaa aacctgccac tgttttacag gaataagaaa  228001 gatggtaggt aaagaataga caaaggggcc aggtgcagtg gctcactcct gtaatcccag  228061 cactttggga ggctgaggcg ggtggatcac gaggtcagga gttgaagact agcctggcca  228121 acatggtgaa accctgtttc cactaaaatt acaaaaatta gccaggtgtg gtggtgggtg  228181 cctgtaatcc cagctactca ggaggctgag gcaggagaat tgcttgaaac tgtaaagcag  228241 aggttacagt gagccaagat tgcgccactg cactccaacc tgggtgacaa gggcaaaact  228301 ccatctcaaa acaaaacaaa aaaagaatag acaaaggtcc agaaatagag gtgttactgt  228361 cctgtgaggc cggcctcatc taagtaagta gaggctggaa tttgctaccc atgaaccttc  228421 cttttccatt gataatgctt ccccactgat aatgtttcaa agccagaagg ctccagaaaa  228481 tcattggtca atagagatgt ttagctgaat gttagctgaa tgggacagaa cacatgggct  228541 gatgcagcca gggactgaag gtgtttgttg ttttttcttg ggcaactgac aatgataatt  228601 tggaagattg ggaaagctag caacttggtg ctgaatctta aatgaccgtc aaagaaactt  228661 ttgcttttgt aaatctatga aatctgaacc taagacttaa cctcttcatt tttcttcttc  228721 cactctctgc tttaagaggg tgcttttttt ttctctctct cccaatgaga attaaccaat  228781 cactttactt ttcacttctg ggggcagggg tgagttgact gaacattctt gcctattgcc  228841 tattcattcc ccaaagctga agtggttttt taaaagtcat gctcatcacc ccttcctctg  228901 gccctaatgc ttaacacctg tcaatgactt ctccttacat tttaaataaa attctcactc  228961 tttaccatgg gttgagaggc cccacacact gtggtttggc ctctccatcc ttatctgtca  229021 ccactttccc tcattcatgt actccaactg cacaggcctg agttttattc ctcagtagtc  229081 ccaagccctt gccccttagg atctttgttc tggctttttc ctctgcttga gctgctcttc  229141 cccagctcag catgttgctg tcttttcttc aaacttcaga tctctgctta gatgacatct  229201 ctgatgttct ttccttgaca aaactttcta aagctacccc tttcaatact ttcccttccc  229261 tcctgtagga cctgctatta tctctatctc tatctcctgt catctacatc tatagctaat  229321 gtctatgtct gtatctctat ctctgtatct ttctatgtat cttacatatt tgttgtatcc  229381 atacctcact aaaatgtaag ttctattata gcagcacccg tatctatgac attgtgcttc  229441 acatctaaga taatttctgg cataagatgt gtggagtgaa tgaatgaatt tcagctttta  229501 taccatccct gtaaaattcc agtaatgggg gaaacagcac agaactgctt gtaagataac  229561 tatccgtaaa ggatgtggta aactcttttt gagaagaaca ttgtttgcct gagaaaagga  229621 agagaaaata gcagtaatta taattatagt gatagctaat tactagctag gcactgtagt  229681 tacctttaca tatatttgct cagttatcag tattaactca agaaataaaa tgcactctgc  229741 aggtggcaat catggctgct cagcaaaagg cagctttccc ttggatggac tatgatgggg  229801 taggtcacat gcagtctgca taactgcatt ctacgtacct tctacattcc acatgacagg  229861 gaatgcttcc atcatgatta acattttctc ttcctgaata gagagaaaag aatgctatag  229921 cctataaata taaaaaggac caatgcctca caattaatgg attcattttg aaggcaacca  229981 agacaaagct ctttttgttt gtttgtttgc tttgatctct cttcaaactt tttattttct  230041 ttgtaatagg tcagtttggc tcctcagtgg cctcatactt cctcttcttg agatggatgt  230101 atggagtcaa tatggttctc tttatcctga catttagcct catcatgttg ccagaggtga  230161 gatctgactt ccagtttaca aaacatgctg aaaaatgttt ctcctagaaa agtatttatc  230221 tcttctttaa agtagaataa ttaactggct attttcacgt cttagagtca taggatttgt  230281 aatgagatta accttcaaaa tggtgcccat gggccaaagc tcccaatcct tgcactaaag  230341 ggggtgtaag cctcttgaaa ttatataact tatgtataat ttcacatgta tgtttaaatg  230401 tgtattttta tgtggaaagt ttcatggctt ctttcagttt cccaaggggg tccctgttcc  230461 taaatgttaa aaactattgt tcaagaggaa gactttgaca ccttgtgagt tgtatttctt  230521 tattttgcca agttagcttt gaaagaaatg cttccttaat gcaactcaaa gcctccagat  230581 tttctatact gaagaaacac aaaatgaaca ttttccccct aagatacaaa gtaagataat  230641 gcccacaaca cacacacaca cacacacaca cacaaatagt gggatgggat gagagtggga  230701 tgggatgatg aggtccaaag tcagaaacta aaacacatag agggtccaaa tcaaagaaga  230761 caaagccctg agctaatgtg gggaaagggt cagctgaggc caaaaagcta gactgaggtc  230821 agagccttca ctcatatgaa gttaaatgat tctgacacct ttgaatgctt accttacaga  230881 agttggatta ggttttagtt aacctacaaa ggacctttta ggaccagtat ttcaaagcaa  230941 atttggtcca tacagcattg acagtggcca aaatttggtg gttttgggtg actttttatc  231001 ccgatagctt caaatcagtg ccagtttcta tactaagact cctattaaca taataataat  231061 aataatgctt tacattcata aagagatttg agcttttaat agtacaaagc actttcactt  231121 cttttactta ctgtgcgtca caacaaattt atgatgtaga ctgtagaaga cattttcttc  231181 acccatttaa aacatgtaaa tggagtcaca taatgctgat gtgacttagc taacatcttg  231241 gaatatattt ttttattaag ctgatctagg actagaaccc atgattcaat ccctttctct  231301 aagattttgc actttaatcc actagtttta taatccttga gataattcca gagcttctaa  231361 agttgtctgg ctcgtagaag acagtgacca aagatcagag gtcctgtgta gtttatttcc  231421 caagtgcaca ctttcaggta atgaagctga atgtgtgtat tttatctatt tcaaattaac  231481 cccagctttt tttttttttt ttttttttgc ttacctttct aaggaaatct gaaactcctc  231541 cattccatca ctggctacta tgacgttact tagtgtcaga tgcaggtata aatggagttt  231601 tatcagcagc atttattctt tcccccacac catgctgcct ccatgtggag aaaatgaaag  231661 gctgttgctg atttatttga ataatacgaa attacagaat gtctgctatg tagtggatgg  231721 agtgcctacg tgttaggttg gatgtattcc aagagctagg aagcattctg tctttggata  231781 cccttttata ggttgtatta ggtgctgagg ggcatcctgt tttctgggca atgattacca  231841 actccagcaa aagaacaaga gaatggacac cctgcatgct gactttgcag aaccaccaga  231901 ggccagggca gtcatctcct ggcagcaacg ctgtattttt cagctgcctc tacccgacgg  231961 gctcactcag tattcctcca aggcaaatgc ccttttgccc caaggtcctg tgtccctggg  232021 caagcctgag accttgatct cctttgtcct ctgtgccccc gaactttggg gcgagacagt  232081 gtgtctggaa cccaccttct attctgttcg gaccaggaag ccagatgggc caaaggccta  232141 ctttgggagg ttgtgcagct tgtgcacagg gagtgagcag agattgatgt ccagcccttg  232201 ttcagtcaag ctctgcaccc aggcttcaag ccatattcat cttctgttcc cagctttagg  232261 agggaagttt ccatctcaca gaagaagcaa catctgcttg gtaagctatg ggggctagaa  232321 aggtgctctt tccagttctc accaaggcac cttcctatga ccctattctt gccctctcac  232381 tggcccactc ttcccagtac tattctccct accgtttttc tcttccaatc tggtagcatg  232441 aatttgaggc agcagtcctg aattagtgat gaagcagaca ccataatcag ggtgcaagtg  232501 ttctcacgtt gcagacaccc acaaattaca tgattggatt tccttgagtt ctctctcttg  232561 acatgaagga cagaatctcc ctccaccctc actcctaagg ggtattctct tatgaaagtg  232621 tgggtaagat tgttttgttg agtcctatgt gactcaaaag gctacctctc tcctttccag  232681 acttccaagt cagaacagtt tggtggtggt ggtggcaatg gggtcctcag aaagccctct  232741 ggggaatgtg gttgacctga ctgcbggtgg tcccctgaac ttggaatgca gggtcctttg  232801 cactcccttt gttcttacct ctggatttag tagtcgattc ccagaaaatg ggaccccaca  232861 tggagaccca aagagtcccc ataaaaatgt ttcagaaggg cttttaaaca aaaccatttg  232921 tgatcacatg tgtggctcag actttgtttc taattgttca ctgctttctt tgcttcttca  232981 tacagtacct ctggggtttg ccatatggca gtttacctag gaaaaccgtt cccagagccg  233041 aagaggcatc ggcagcaaac tttggtgtgt tgtacgactt caatgtaagt gtctccacac  233101 aagtgtattg gtgggaggat ggatttttat ttagtttatt ttattctgaa acccacggcc  233161 tcctctcctg ggtcaggctg aatgtcttaa gaaagacgtc cctgctccct ttaagaaaga  233221 aaggaaagaa agaaagaaag agagagagag agagggaggg agggagggag ggagagagag  233281 agagagagag agagagaaag aaagaaagaa agagaaagaa agaaagaaag aaagaaacat  233341 gtccctttat ataaatgtga ctatgattta ggacaatggt aatatgatta tatgggaata  233401 tagactactg gataaaggtg agctcagagt tcaaagactt gaagcaaata ttcttatcac  233461 tgactttgga aaagaataaa ggaagagttt gcaaatgtgc tttttggaaa atcttgttgg  233521 attcctaggg aattaaaact tttacacttc ctattaacct ctttacttcc taaacaagcc  233581 tcctatttag tattactcaa tagttagtac taaataaagc taaatattga aaactaagaa  233641 atactaaatt ctaactttta aataatacta aaattagtat tattccattg tagtattcaa  233701 atgagcatta ctccttgagc tcccttaggt agagattatt actatggaaa ggagttattt  233761 ctgtccattg aaaaaccatt ttggactata tgattcaagt cttcgacaac aatgtaattc  233821 cacatattct ttttttaagt agtgactaga ctagaaatgt ctggaagcat atgcgtggga  233881 aagtagccag gttgaaattg aggaattgat aattcaagta atttttggag gctagacaat  233941 gagaataaaa ttttatacag attgcagaat gaaggaggga aaagcagact gcctgtttat  234001 agtgttaata tgtatatctc acaaacattt tgatttctac ttttaacctc cttaaattgt  234061 gagtttccca aagaagagat caggtctgct acatcttttc agcccgtaat ctagtcctca  234121 tccactacag gctaaatgaa tctcattgac tgaaaatcct gagtgagggg gatgattcat  234181 agagccttga agtaagaacc acaggaccag tttatgtgag gagtaccaga acatgcaaac  234241 cttaagaaaa gtttcccatc tccgaatgaa caaagcaagc tattgagtta gcatgaggca  234301 caatgatagc aacaaatatg tggcatttgt aatcttcaat cacccctgtc agttggactt  234361 tccatttcaa ttcagcattt tttaaactga attataaact tgcataggtt ttacaaagat  234421 gaatgtgaca tgattcttga cttcagggta ctcgtgatat tagaaggaag acacgtaagc  234481 aaccagtata caagatgctg tgcacaaagt tagcaaaatt taaaaaaagg aaaaaagatc  234541 ctggggaact gagcaagtgg ttcttatttc ttcttaggcg ggtctgggtt ttacagaaga  234601 gatggcctct gagttggatt ttacctctct tttctatcac ttctagattt tatttctctt  234661 ttctaccact tctaacttct tccacctctt cctcctcccc tccctttatc cctcccttta  234721 tttatctctc tcactttcaa atttcaaata atgcattact atgtcccttt accactgttt  234781 taatttctca ttctcttcct ctgattagca aaatgacaaa cttccagtct gcttaataag  234841 aacaaggacg aagatcactg actttttctg ttttttaagg catagcagag aaaggaagga  234901 ctaaaaatat gaacaaaagg tcttttgatt tttatatata gatttctgaa gtttaaatac  234961 ttctgaattt cccaatgcac tgaaatggaa aattttgggc aaaaatgtcc atttgagatt  235021 tgaaagttag tgactcagtt gaggaagaca aacagaaaag ttgctgtaag agagttacta  235081 atgagtggac aagagggtct gagaggcaaa ttcaggggaa agtagaggga aagggtttgg  235141 atgatgagtg tgcttcccaa gattgtatca ctgcccttga cagctctctc acatccagtt  235201 tggtgaaata tgatttgtcg gtcagcaggg gatacagaaa ccagagtgtt ctatgatagt  235261 tatttcaagg cctgcctgaa aacaatacta aggcaatgag agaaatttta aaggtcaaga  235321 aaatataaga aagccattac actgatttta ttcacttaca ggcttgctgc atgctggtat  235381 cagtcattaa tttggtatgc atcattgctg gggttagtag tgattttaat agctgtattt  235441 ctccaatgtc tgcatcatgc agtgaactgt gattggtaag taaggtccct cacttcacaa  235501 cccacttcat ggtgggtatt tatatctgag actaagctcg agtgttctta tatgtgaaat  235561 ggagaaaata atagtatcta cctcaaaaag catcaagtga gataatgcat gaaatagcag  235621 atagctcaga gtatgtagca cacagtacag gctgagtatt ccttatccaa aatgcttgag  235681 accagaagtg tttcatattt caaatttttt cagattttgg catatttccg tatacataat  235741 gagatatctt gaagatgaca ttgaagtcta aacacaacat tcatttagtt tcatatacac  235801 ctgtacatat agcctgaaag tgattttatc caatatttta agtagccttg ttcatgaaac  235861 aaagatttga tggtgttttg actgtgacct gtcacgtgag gtgaggtgtg gaatttttca  235921 cttgtggcat catatcggtg ctcgaaacat ttcatatctt ggagcattta agagtttaga  235981 ttttttttta ttaggaatgc tcaatttcta aatattcctt attacaagaa ccataacttg  236041 accaaaggca aacagctatt aggaaaccga attgggatgc agggctggtg gtattacaca  236101 cggtaatgta tgtggatagt ggcaagctag taaaaggact tttattataa caaagaagta  236161 aatacataag taaataaaag tattctgacc ttaatgagga gttcttgaaa gattcaagga  236221 aaggaagcaa taggattata tagtcattat caaattgttc attgaataac attattattt  236281 aaaagaaaat aatactgctt taaggaattt tatatgatat acaagttttc atgacttttg  236341 aagtttgaaa gatttgtctt ttgttttggc aatgattata ttctaaattc agcaggaaag  236401 ataggttgat tcatattaag ggacactttg cttttacatt tttgtaagaa aaaggaattc  236461 agcccatcct acaataagct aataattgag cacattctct atactagggt caaaataatt  236521 tcacaagtac atcaataaga gagagggaag gacctttaat tattaaactg aagataacaa  236581 caagaaaaaa atgtacaaag cttaatttaa aatataggag atttggtttc acagtaaaaa  236641 tccaaaagaa taaagccaag tagtcactgg taataagaca ttatagattc aaatgagatg  236701 ctgtcttggt caggacgtgg tgtcctccac ggcagaaggg aagaggctgc ctgagcacag  236761 attgtcttga gtatcgtgca tagatggtag agatcagacg ccacagacag ccgtgggctg  236821 tccctttaag aactcccata gaatgggcag agatgtccta gaattggaca ataaggaaag  236881 agtacaagga aggaaaaata aaatctagcc aagctcaagg acctgtatgt gttacctcag  236941 gttaaccaga cgtttctcag aagacagaat ctaaatttct acttacattg cttttgtttt  237001 tattatcatt tttgtgaata ataccaaaat taatgtagac taagtactta tatgggcagg  237061 cactgtgctt agtgctatga tatttctatt tatttatgaa tattatactc atatatttat  237121 agtgatttat actacttgtt tcagtatgca tcaagaaatg gaaggcacag atatcttgac  237181 agagataatt taatataaga aattaaacag gtattgggtg actaaaaagg caaaagggga  237241 cattgaggta acatagaaat ggtaacaggt aacacagacc agtttttacc cctactgttg  237301 ggagaacaaa agaggaagtg gggttattag aatctagggg cttggaggaa gggcgctgca  237361 tggccccaag aggtgtgatg agattggttt tgagtgtgct cgaacagact ggaaatggaa  237421 ccaaataccg ttaccagagt gaagaggcat tgctggagcc atgcattcag gagagagcaa  237481 atcccttctc ctgacttttt gtctaagtgc ctcctatagg aaaaatctgc aaggaatccg  237541 atctcaaagg aaaaaagtag ctccccaagt cccgtctcca gcatcacaaa gcagcatata  237601 caaggatggg tctgaagctg aaacagctta ctaactggca cattattcta tttatattat  237661 gacctattcc tcttcctagt ccagtaaggt agatatgact attcctaatt tacagatgga  237721 gagactgagt tttagtagga tttggtattt tcctccaagt tccgtggatg gcaagtggag  237781 aggcbgggat gctcatctgg tctgcctgac atctctgtct gactctgaag cctaggacaa  237841 gctgcctcta cataggctac taggagccac tgagatggct acaggtttat actggaaatt  237901 cacaaaaata agagaatttt agaaatagag gtgctcttcg atatcttcca tcctatatct  237961 taccttataa agttacagaa attttgagtt actgaagcat gttcagggtc ttatagttgt  238021 taagaggctc ctaatctagt gttctcttca tgtcctgtat tccgcccgta attttcctgt  238081 tgtaatttcc agcaacattc tcactgactg ctcctggaac atttactgac tctgtttcat  238141 gatatatcta tttcacaagg ggaaatggag ttgaagcatt tgggccccat tttaatcttt  238201 cataataatc ttgtaattcc caaatcagct tctcaaatag aatgagagct ttcatgtttt  238261 tttttcctaa attctttttg tatcatttaa atattatgct ttattaaaat attcataatg  238321 gaaaatcata ctttgaaaat tgttattatt aattttgctt tggttggtta gcaaagttct  238381 atctttagtt tttaaaatta atttattttt gaaatagaca ataaaaatcg tatatttgca  238441 tgagttcttt gcttgatcct ctgaacaatg acttcataga ggtgctcact ctgtattgtc  238501 agatgatcta agtatacaac ccagtataca acccagtatt ccatctatca tggcaccatg  238561 gaggaaatca ttgacaaaat gtttttaaac tccttaaaaa ttcataatcc tgacttttgc  238621 aaagcccagg ggtgccaaag caggcatccc tgggcttttg aaaaatgcca ttatttaagc  238681 tagagccgtt atctaggcta tcattatcta ggtagagttt ggggtgtgtg tgacctcaat  238741 atgaaaacat ttggatccac tctcttggat ccaaagagat ggcatctgga ggctgtctct  238801 caaaggagat ctgagcagca cacccagcaa caggatcagc tgaccttgga cagactatat  238861 agaggtaagt tattccacat agaggcaggt gaacagaagc agaatagatt taagatctgc  238921 acttacagaa taatgtaaga taaacacaag catgatctct tatggtacag gagcctattg  238981 gatgggaagg atcagaaaat ctttggggta aggtagggga ggttgtgagg aactaccaat  239041 ctgtagagct tcatctggga accttggaac ctcctctcca tacccatgaa agcgcagtgc  239101 tctgtgactt agatgtatat atcacaactc atccaaattc tcttcagtta atagtagaca  239161 aacaccatac acaacatgca tgatcagcta gtctcagggc ttttcaaagt cagaatttac  239221 catttatgaa acactgtatt tttaaaatat tcttattgag tgcataatga tacatcttac  239281 tgatggtgct ggaaatctgt tttattaaaa tagtaagaaa cagagagatt attatgtatg  239341 caatgaatca aataagcaga aattgtatca tgtaaattaa tagaagcaga agaatgagtt  239401 taagtcagta ggaagaggat gtctttgttg gcaagatacc tggagagaca agggtgatat  239461 agaaatgata aagaagaaaa ggctacacag ttttaatatt cttgtgagga gaaagaagga  239521 ggaactaaag tggaatttgg aaggagcttc agctgatatc agacagtgag atcatatggg  239581 taaaggttta agttgtgagt aaagggaaat gcattctgct tttcaccttg agagcatctt  239641 gtacattgct gatggataaa tggtatgtct actttgcctc cccttttctg ctgattatca  239701 tagatgtggg agatagaaga tatcctacaa tgggcaggag aggagactta acacctatta  239761 tgtgttaagt aggtacatac attaaatttt atcctcataa caactgttta agatggaata  239821 tatcatccca gattattcct tctgccctgc ctgcctcaca tcccatcttg gaggtttgtc  239881 cttaaaggag acaggttaga cacatataga atgttaataa aaaggagata agttctttaa  239941 tcaacatcaa caactctttt cagtaataat gttccaaagt aaaggtgtct tctctcaaac  240001 atatctcagt tctcttaagt tccttcatct cttattgcac tggacacagg tagaggagat  240061 attttgtgat tcacacgtgg aataacacat cttttgtttt agaactattt cagtggttcg  240121 aatgcatctt tatttgaaaa ggtgaatcat tttaggtttc ctgaggtgta gacatcaaaa  240181 ttatgttaca tgcaggagat attgggggag ggaggcgtgt gaaggataaa ggagagagtg  240241 aacaagagta gacaggaaga gcttttagat ggtaatgcag gccctatacc tgtgaaagga  240301 gagagaaaag gaaggattta ggaagagtct cagattgtac tacagttttg aaagagtctt  240361 ggccaggcta acggtgagtc tctaaacaaa gtatgtccat tagataaatt ccatattggt  240421 tagcaataac ccagctccag tatttcccat catgctcagt cattatctag gtagtggttg  240481 gggtttgtgt gacctcaatg tgaaaacagt ttggtccact ctggtgggtc caaggaggtg  240541 gcatctggag gctctctctc aaaggagagc tgagcagcac gcccagctgc taccttgaaa  240601 atgtgactgg gctcctccac tttagatcat agctgttcat attgcbgttg ttgctgttat  240661 ttagtttcaa caggtttcaa atgcagccag aatgacctgt ttcccacatc catcgtctgg  240721 gcctacctcc gtgcbgggtc agcagaggct gaacttctag atcatgaata attcttcggt  240781 ggcatgaccc caagcgagac tgctaagcct cttgtggaca aatttagagt tataaatttt  240841 caaatccacc tagagatacg tctctttccc tagtagcaga gatcataact ttggaggggg  240901 tgaggaccct ctcatctgtg gatgtagtga gattcctcca atggctttgc tgagcagggt  240961 gggctgctgc tcaggcatgt aacgcbggga ctggcagtat caaagggctc tgtcccttat  241021 ttacttcact tcctcaatgt ccagtgtggg tctctttggt tcaacaggct tattaagttt  241081 gattaaaaga agatgcattt catgttctat tctaggtcct agatcacttc ttttgctttg  241141 taagcttctt aatttgctac tcctgagtga ctttatgaca cagctctagc ttgtgacgag  241201 agagattcct gggtctgctt ttagcttcct tggtatttta aacttgggga actgatttct  241261 taaggtctga agtcctagcg atgccttttt tttttttttt tttttttgct ttagtaacac  241321 attttagttt tcatcacctc cctcaggcta cacttggcca aaccaaaagt gagcttttct  241381 tttgcaaata ttagggatgc atatgatcct aatgctatac ttacaatatg aaaacagcat  241441 tccttctttg gaagtgacca tagaaatgag tcttcttttc attaacatag taaacatttg  241501 ttgggcattt gccaggtgcc aggcattaag caaagatgag aaaacccaag gtctctgtcc  241561 tcaggaacat aaagtccgag ggagtagtca aataatcaca aaaataaatc caactgtaat  241621 tgtgccaagt gctatgaagg aaagctatat agtgttaaga gaacttatag aagacaacct  241681 gatgtggttt aggagctaaa ggaaggagac agataaaaga aaatattttt ctctgagaaa  241741 gtaatgttca aattgggctc taaggagtca ggacaacctc tgaatttgaa agaagggaga  241801 gatattctca gcagtaagaa catcaattac agagaacgtg tgatgataag aggtggcctt  241861 attcagggga ctgagtaaaa cgagagagct cagaatgtga agggacatca gaacacaagg  241921 cattggagag acagaaggga accaaagcac gtgggatcct ctaaaatcta gactgcacta  241981 attatttttt ttttttctca gagcaattaa aagtaactta agtggggggt aggtgggtag  242041 taacatatca gacttggatt ttgaggtaat caacagactg tagacgggca agatggctgt  242101 gaggagatca aggaagaatc tttcgatatg actaggttag agactaaggt tggaagagct  242161 aaatttacct ggcaggaatt ttctatatct aaatattggc tgccaaacta atagattaaa  242221 ggatgagcca ttgagttagg ttagaacttc acaatgcatt aaattatagt caataattta  242281 aacacatagc accaaatcat aaatctaata catctgtggt gacaagtaga ttatgtaaat  242341 ctacattcat ttttttccaa gtagctgcaa tatattcttt acattttaaa ttattttatt  242401 tgttcaaaaa ctccttttta aatacataat accaaggcat ctcccagtat aggctgtgtc  242461 cagatgacca cacacgtctc gtttcatgta tgaattcaca aagcttcact ctgaatattt  242521 taaagaacca gcagcaaatt tataactcca gaagtcaacc agccaacaaa accctctaat  242581 atgcttttaa tctcctcctt gcgaaatgaa agaagacaac ttttttttct ttgtggaaag  242641 aaattataca taaaagctca ttttatagca ctgagactgt ctcattttgt taagagtttt  242701 atgcaattag acagtaggaa aaattaaaga gtttttccag tttcagtgtc tctcagacac  242761 ttctttggtg ttttgattca ttaaatccca acataagatt attattgcca cgttactgtc  242821 ttggatgatt tactctattt tattaaaatg ggtagcagag agcagaagaa taaaaaaagt  242881 tggtgtacat gacaatttaa aggagcttat tctaactgag gattgctaat gattaccaga  242941 agcaattttt ttttgttcat tcaatcactc cacaaatata aattgaagtc agatgttggg  243001 aatacaaaga caactaacat atattccctg cccacaggga cattatgatc taattggata  243061 tgcaaacaaa caattgccat gcaaaatgac aatctgaggc tgatgtacat atgtcttagg  243121 cacttgggaa cataatggaa taagggttca gtgtccgggt taactggcat tcagatactg  243181 gactcttgag agagcccagt aaagagaacc tctatttccc atgtgagttc tgaataattt  243241 gtttaaaaag aagaggcaga tgggcaaaaa atttttccac attcattatt aatggaaatc  243301 gaattggagg aacaatccgg aattcttagc caaatggtct tgctgattta gaaccccaaa  243361 ttagccattt tacctctagg gcaacttatt tcctagaaga agaaagatat gtttgggctg  243421 ggccagccca gttaattctt tcccagttta ccaacagaaa tcactatgcc tttcctggtg  243481 tgcagtgagt atagggacag agaaaagctg aggcatattg catcaagtga agctccgtgc  243541 ctctgaagga aatgctgaga gaaaggaagg ggcattcatt acccctatca caactggctg  243601 tggttgagag gtcaacaaag gctttacaag tatcttgaac cagctttaaa gaaagagtag  243661 gaatagagca ggctctagaa tggggcaggc aattgggaag cgaattccaa gcagagagat  243721 cggcatgcac aaaggcatgg aggcatgaga tagtgctatg ctctcaacac ccaagagtga  243781 ttcagcaaag ttcatattta gggagaaagg agggcagcaa gaggtgagcc tgtcatacta  243841 aaaaaaaaaa aaaaaattca aaaaagagcc tgatcaggga gagaatttca ttatgctcaa  243901 gtcagacttt atcctatagg cagcggagcg cacctgagat aggaggaagg agcaggtttg  243961 gggaattttc ttgaatgtgc tatgttcatg cttcctatga gacatgcaag tggagtgaga  244021 tgtgtaatgg cattgggcat agggtctaga attcccactg ttagtgtcag tcgtgggcca  244081 tggcacaaaa ggcaaatgga agtactttct atagaagcca gaagagttaa aaatgcagtg  244141 tagcataatg acaaaaacta ggcatgagat tccaacaaac ctgggtttga atcctgccac  244201 atacgaccta tgagatatta gacaatcatc ctgaaccttg tagttgccat gtataaaaca  244261 gcagtattaa tacctagcta ccaggcttgt ataaaaaata catgagatta tgtgtgtaaa  244321 gtattagcac atctcggctg ggcgtggtgg ctcacacctg taatcccagc actttgggag  244381 gccgaggtgg gtggatcaca aggtcaggag atcgagacca tcctggctaa catggtgaaa  244441 ccccgtctct actaaaaata caaaaaatta gcbgggcgtg gtggcgggtg cctgtagtcc  244501 cagctactcg ggaggctgag tcagaagaat ggcatgaacc caggaggcgg agcttgcagt  244561 gagccgaaat tgcgccactg cactccagcc tgggtgacac ggtgagactc tgtctcaaaa  244621 aaaaaaaaaa aaaagtatta gcatggctct ggcacatagt agattcttct ttaaatgcct  244681 cttcaggata cttagctcat gaaaattccc atttgttgga gggacaagga aacagaagga  244741 aggaacttgt agccagagca agaaagtgga agtggggcag cagccatgtc ccctgtgtag  244801 gcaggaggca gggggacaag agtaccaatg caaggatgga gggatggata cccaaaggaa  244861 ctgcctcatt cacagctgct tgaggggcag agatcactgt ctacagtcct taacacaact  244921 tgattccctc tgctgaaaat tagatctgcc taggctcagc tcagcttcct ctttgtactc  244981 cacactgtct ctgttaagaa ccatagagca cctgtttcat gtctatgaat ctgggttgga  245041 gcaaaaggaa aataaaataa aaaaaactca gagatgagca aagtattagg cagaagccta  245101 atgggtctgg ctggagagga ggagtgtggc catgcgctgc tgtcagcatg cagctcacaa  245161 ggcccgggct ggctgctgtt cttgtgacgt tagttgaggt ttattctggg cataattagc  245221 cttttcactc cttgtttctt tcctgtgttg cgtcctactc catgaaatgt tgagtgccag  245281 tccttgtctt tcatccacac ttgaaacctt cgttcatgct aaggtgtaaa taaccagcaa  245341 caactcagag aaaagtagaa atacacccag acttgaatct tgcagtgtca cctcccctca  245401 cataccctca gcagatatgc ttaaaaaatt atatcttcct ttcctaccag ttttacttta  245461 tacattcttt caaaataatg gtctggcagc tattacaaat taaaaagagt tactaagaat  245521 gaagaaattc aatgatcatc ctggggatag agtgttatct ttcatggtga acatttcttg  245581 gtaatcatga gaaacaccaa agggatgcag ttttaatata atttcaggca acaaataatt  245641 atgaaggaga tgttttgcat gcagagcctt ttggggacct ctgaaatcct gtctcctaat  245701 ccatctatgt atattgggca aatagtaagt tctcaataag tgttagttag aaaagtaaat  245761 gcatgaattg agtcctggta accataataa aaacagtctt tcttgtggaa atgtgttggt  245821 gattatggac tggaccagct gcagcaatca aacagaaatt agagtcttaa tagacaacac  245881 acgagcatgg caccccagag ttggacagaa attttctgtg ctcactggga acttggctct  245941 gactctggtt tctctgtcac agattttggg gtgggagagt gctcccatgg ggaaagcagc  246001 acgtgctgat atcgaaattg aatagaacct tggctgggct aggagtcatt gctattttag  246061 tcacttccag atgtctgctg ctgtagtttt aagggacagg gaaagatgag tggagtgtgg  246121 catgccactg ggtaaaagat gaggagcgtt ctccttctaa gcccttcaag ttgtatttaa  246181 agccatccct caatatgcta caaagatgga ttggataaag cctttaaaaa ctgtgttctt  246241 ctattcacaa tagcaaagac ttggaaccaa cccaaatgcc catcaatgat agactggata  246301 aagaaaatgt ggcacatata caccatggca tactatgtag ccataaaaaa ggatgggttc  246361 atgtcctttg cagggacatg gatgaagctg gaaaccatca ttctcagcaa actaacacag  246421 gaacagaaaa ccaaacacca catgttctca ctcataagtg ggagttgaac aatgagaacg  246481 catggacaca aggaagggaa catcacacac tggggcctgt tggggggttg ggggctaggg  246541 gagggatagc attagaagga atacctaatg tagtgacagg ttgatgggtg cagcaaacca  246601 ccatggcata tgtataccta tgtaacaaac ctgcacattc tgcacatgta ccccagaact  246661 taaagtataa taaaaagtta attaattaaa aataaataaa caaaaactgt gctttttaac  246721 attcatttat agatttgact tcatatatat caaataggca aactgcagaa acctttgtga  246781 actaatcatg actctgcctg ccccaactag aaaaacaaaa caacacaaaa caaaacaaaa  246841 ccagaaccat tcttgggctt tggttatgat ctagtattta tgaagtgcca gccattaaac  246901 atatgttgaa tggtacctat gccagatgag ctggctgccc ccagtagcta ttgtgctaac  246961 ctaacaagct caccagatgc ttgttctata tctgctttct ccttttatga tattttcggt  247021 gtgtctttta atcccaaaat tgtcattatg aattagataa aagatatcag gtggggggtg  247081 accccctctg aaatattctc aaaagggatg cctggggttc tttccaagag gccctgtcac  247141 caccagggac cagtctaggg tatagatcaa agtctgtgat gggttcatag agtttcttgt  247201 ttctttcctt tctttcactg agaaggtatg gcactagcat gatataactc ttgctggata  247261 aagaaagcac aggagaagca gtatagtgca gtggttaagc atataggatt tggattagac  247321 tcaggtcaag ttcagacact gtcactcatt agtcatgtga acttggacaa attacttaac  247381 ctctctaagg ctcagtttct tcatctgtaa aataggtata gtgatagcag ctattgaatt  247441 tttgtgtgtg caggagaggg gaaaattatg gtaaataata attcctccct tgtccaacaa  247501 gattgtgagc tcaccggaaa tataacaaag ggtaagacca gtgaaggtca acatgccgcc  247561 tttattattg ttaaagctga cataaaagaa tgtagtgtct ttatggacaa gtgaacttca  247621 cagccagacc tctctgccag gacaggcctc tccttgcagg agcagagcac agcatgttcc  247681 ctctcaagag aaggaagaga tgtccgcatg tctccatcca tgctctactg tcaaatcagt  247741 cacttttccc cgaggctaga gtgaggcagt ggagggtggc tgggagtgtt atgttaatgg  247801 gtcttcactt ggaagggaac gtcaagagtt ggagatacga ttaccctagt agcagcaact  247861 tcatagtgtt ctcctgagga ttctgtgaga taaaataagg tgtttggcaa gtgctaaatg  247921 ttcacgaaat gtatacggtg atgttacttg tcacagcaac cattatcact gagtgtcaca  247981 tctgtggcaa ggaaataggg caatgaaaaa cagagacatt tggaagttgt ggtgttgtcc  248041 catgagggtt aaataaagag ttcaggatat aatctttaaa ccaaacaaga gattaagtgt  248101 ctatacttag catgttctgt tattgtcacc ctgggacaga ggaacaagca tgaaggttta  248161 agacatgata gaaggagatt ggatttaaca caagtgggaa gaagcagaga tcttaactag  248221 ataaatgtga aacaagaaga tgtcatgcac ctgggagctg ggagatcctc ccaagcatat  248281 tctcctggga tgaagatttc tgggtcttgg ggagttggtc aatccatgtc ttatcttaga  248341 catgagatta gctcacccac tccctctgct tgaggtttct actagctgtt tatccccaaa  248401 tgttctgttg gatggcatcc tagtcagggt tctccagaga aatataacca gtagaagata  248461 tgtatacaca catacacaca tatacatata tatatatata aaatttatta tatcaatcta  248521 gtatttatat aataaattta ttttgattta tcattattat tacttaaatt tattatataa  248581 atctttatat atatatatat gcatataaaa tttgttgggt tttttttttt ttttttgaga  248641 cggggtctca ctttgtcacc taggctgcag tgcaatggtg tgatcttggg acactgcaac  248701 ctccacctcc tgggttctag caattctcct gcctcagcct cccaaagtgc tagaattaca  248761 ggtgtgagtc accatgtctg gctgatatat ataatttata agttaatata aataatagat  248821 ttactacaga tataaaagga gattcatttt gaggaatagg ctcacacaac catggaggct  248881 gagaaatctt ctaacctgac atctgcaagc tggagatcca gagaaaccag tgctgtaatt  248941 cagtctgaat ctgaaggcct gagaaccagg ggagccaatg gtgtgaatcc cactctgagg  249001 gcaggaggag atgagatgtc ccagctcaag cagtgagtga ggcaggagaa aaaggagcaa  249061 atccctcctt cttccttttg ttcttcctct ttttgtcctc agtggattaa atgatgtcca  249121 gccatgctgg ggagggcaat ctactttact gagtccacct atttaactgc tcatcttatc  249181 cagggacacc ctcccgggca tacccagaaa cagtgtttga tatggacacc ccatggccca  249241 ctcaagttgg cacatacaat taaacatcac aagttggctt tattttttct taaactgaaa  249301 aatgcagata caggcctgtg tggcccaggg aaacccagac ctttggtatt tacctgtgat  249361 tcattccgtg cagtcccgag ttaagcacac aagttcctct gagattattt ggagatttta  249421 ttttgttcta gttcttaaag agtacaatat ttaagaaaat ttgccccata ttttgaaagc  249481 aatagttttt cagatctctg ttggcctctg atttgagtta ggcatgatgt ttgtttaagg  249541 caattttcta aattacttct cttaattctt cctctaggaa ttagcatcta cgacatttct  249601 actttctttt ccacacctcc actctccccc acttcacttc ccttcttcag ctgtgagtgt  249661 caaagtccct gggttcgtat aaatgatgtc aaaggcaacc aattgggttt tctaagattc  249721 agggttgact cacctgatct caagaggaag ccccatattg acaagtgatt atcttctcat  249781 ttcacaaaac atagttattg tcagagagaa gtaagagggg agcbggggag tggatagctg  249841 tagtgataca gtaacagtgc ttcaatgctg aaagtgaaaa acacagtgaa tgtgaggaag  249901 agaaaaggtg catattataa aggaagcagc atcagaatat gccaatgttc tgagaataaa  249961 gagggagtta ttcaggtggc tttgagagag ggtgatttca accctggcag ataattttta  250021 ggaacgagaa tctaatgcac aagtaaacat gcttgttata tgggaatgct gtgatagtct  250081 tgatgaatgg gaagtgtgca gatgagttcc aatgtcatcc cacctgctct ttgatatttg  250141 tgaagtgaga gctgagacat aacctctgtg gtttaagaag aactgatcta attatggtca  250201 ggtgattgga aatggaaatc tgccacagca ctttgaggaa gcatttttca gatccccatc  250261 ccctagtatt aagcaaactc ttaaaatcgt aaatctaatg ataccacgaa atgtgttttg  250321 atgtttaaat caaagggcat ttcacggtaa tggctccaca gctgagcaag cctgtatttg  250381 cttaaaaatt ttatctattt agaagtcact gattttcaaa taaactgaaa agctgccaat  250441 caacatggca gctgaaacat tcactttatg gagcaaaaca atagggctca tgtcagagct  250501 gtgacccaag tttgaaaatt aatgtcattt tgttatttct cttaagagtt gatcttttcc  250561 tttgagttgc tcttcacgac aactgctaag tggctttgtt gttggatttc agggtttggc  250621 acaatattcc gttctctttt atggctatta tgacaataaa cgaacaattg gatggatgaa  250681 tttcaggttg ccgctctcct attttctagt ggggattatg tgcattggat acagctttct  250741 ggttgtcctc aaagcgtaag tttcatttgt cttttgggaa gcaaataatg atttctggaa  250801 tcaaatggag ggattaattt ggggattgga tataattttg ttgctatttt atgtctaaag  250861 gaaacagagt ctgtaagaga tgaaatgtag ttttaatacc aacactaatg ttagactatt  250921 acatcttcaa aagaactgaa cataaacaca ggcctttgag tcatctcatg gggtcagacc  250981 aatgcttgca tgcctatctt gtgtttaaac atatttttta aatgtgtatt tttgtacttg  251041 aaggtgtgaa ttaatgttgc cagcaagaca ggaaaacagc tgcbggtctc tcttttgcgt  251101 gcagagaggt ttgtaacttg cagaatcagc tcaataggca gaatctattg ttctctgctc  251161 attttttaaa aaaaccagaa taatcactca ttcaaaaaat tttagctgtg taagacagca  251221 aaaatgaatg gtccccaatg aaaccatcac aatcaactgt ataatcatgg tttgtcttgg  251281 gaaaagattt attggagtat ggggaagaat ttcactggag aactgatatt actgcagttc  251341 atttttctcc ctgcctaaaa ttatttataa tactccactt aaagactgca gaagcctagc  251401 agagttattt gggtttatat attaaaaaaa tgacccttta gccaattttt tttgaactag  251461 tttacgagaa gagttgaaac atctcaagta aggttgccat tcttttattt gactatgtgc  251521 aagttgaatg agcttttccc ctcattgtag gaggtccctc agcctgaggg tctaagaggg  251581 gaaaagtgca aagtcaccct aagcaggagc tctctgaagc agtctgtgac acactttgtg  251641 tcctaaacct gcctcactta cttgttcctc cagagaaaac tgccatattt catttttaag  251701 ctcttttagg acttaaaacc ttataggaaa tcctatatct aagatattta tcaacctgct  251761 aaagtgtaat cagagacctc aaatataaga gactgtccat cagataaact actatcacat  251821 tccaaaaatc gaagatattt tctagtcttt tgactatatt gctctggttg ggctgaagtc  251881 agaggtatca tttacattac tgaggcctca tgagtatcat ttctgtgttg ctcctttagt  251941 ttctgtggtc agtggagaag aatagtttct catgtctgat gactcagctt ttattccggt  252001 aactgtgcag gctgtgtacc ccacagccat tctgcctagg ttcaaatccc agctctacca  252061 tgtatgtatt tatacaatca ttaacagatg gctcaactgc tttgttctcc tgtttcccct  252121 tggtaataga ggtgtaatgg atgtgaggac taaatgaatt aatacaaaca aagcacttag  252181 aatatgcctg gatgagaaaa ttattcaaca aatgttaaca attttattag gctatatttt  252241 attaggctat attatatttt attagcctat aattcatagg cttatttaag aaaaaaagcc  252301 agcatggtag gagttgaggc cacattatag atccccaaaa caaggcagtc atgtatggtt  252361 atgcagttgt acatcagtag atttgtatat ttaataaatg attttctggc agatgaattt  252421 aaagtatcta gagcagcatt gtgccaggca agccacatat ataagtttaa aacttctagt  252481 agtcattaaa taaatagaca ggtacattta attttaataa taaatatatt tgctttaact  252541 caatatatca aaagtattat cattttaacg aacaatcaat ataaaattat tattgagata  252601 ttctctgcct ttcgaaaggt atcaagtctt tgaaatctgg tgtgtatttt ataccagtcg  252661 catttcaatt gttcagtagc cagatgttgc tggtggaaca ctctgttggg tagagtggct  252721 ctagaggaag tagtggcttt ttcaaagttg ctcgaagatg ccatttggga tagctgcagg  252781 gcatcaaatc cacattttcc ccctcaaagt cattcatgtt atatcatcca aaccagtgtg  252841 gccttgaacc ttccctctgg catggacctt tggctgctcc ttacctggtt aacaagtagt  252901 tcaaactcat tgcccaaaca gcaagacaac tcaaaaacaa tacaccactc tcactccacc  252961 accagcccat gggagaatat tcagtagaaa aagaattgat gagatataaa tctttgtaca  253021 gaatcattaa tcatctcttc ctactcctat cccagtcaaa tattctcttg gaataagttt  253081 gagcggattt atgacataca ttactcaaat ggaatagaag gtaacctaag ttctaaaatc  253141 gactaggcta catcaagatt ttttcactgt actcattctg ttagcgtctg catactcatc  253201 cacaaaatgg gagcaaatat ctatttttag ttacttaata gcaaaatcag aaaataaaaa  253261 gatagaaatc caagaaaata gtttgaaatt ttaagataag atgactaact ttgttggccc  253321 aggattctcc tggttttaga actgaaagtc ttgcatttga gaacctttca gtccccaaca  253381 aacatggatg gttggtcacc ttggttttaa gtccttccct tttcttcttc ctcccttcat  253441 tcatttcttt tatccttttt ttttttcctt ttctttccag gtcagtgtac attttcaacc  253501 acatcatatg cttagaaatc ttcatgataa atatagttac ataagtatta aaagcaaatt  253561 aaaacagtat aacataaagt tacacaacat ggaaaccatc agctcattta aatattgtcc  253621 tcattagttt gaagttttat atcataaaat aaaggtggct tgacatcaga acccaactgt  253681 tcccgttaaa aacaattctc taagctaaaa atttggggtt ttactggtct attttacagc  253741 agctaaacta ctggaagcag ttgaatcatt ttgagaatgc atgtcttaat aagaaactca  253801 tagctatttt atccttgtag gctttttcaa gactttttcc tgtttgtagg atgttttagt  253861 ccatttcgtg ttgctataaa ggaatacctg aggcttggta atttgtaaag aaaagaggtt  253921 tatttggctc acagtctaca gactgtacaa gaagcatgga gtcagcttct gcatcaagtg  253981 agtgattcag ctgtttccac tcctggtgga aggcaaaggg gaaccagcat gtgcagagat  254041 cacgatggtg agataggaag caaaagagag atggggaggt gcbgggctct tttaaacagc  254101 cagctctcgt gggagctaat agaataagaa ctcacttact atcccctgca aaagaaggca  254161 ttaatctgtt cataaagaat cttcccctat gacccaaaca cctttcatta ggctctacct  254221 ccaacattga gatcaaatct ctacatgaca tttggggaga caaacagcga aaactcagca  254281 cagggctccc tgggattaga tataattttt ctgtttatga tcctggctat aataatactc  254341 atagaatgga ctaacaaata ttcttggata cttaaatcat gtgctatacg taacccttaa  254401 atggtgtcaa aatttttgtc tacatagact ataatataga ttatatatat atgagatata  254461 tattataaac tacatatatc acaaaccaac ctcaacacat gcagataaat atttttaaat  254521 ttggcaaaat gacagtatgt tcatccatat ttctggagct gcaacaataa ttataaatta  254581 tacttgaaat aataataatt aacatctgtt gagcatctct catgaatcag tttaaattac  254641 attacttcta atccctaaac attgcaaagt agctattagt tttataattt tacagataat  254701 gaaataaaac tcagagatcc taaatgaact gcacaaggtc atttgactat aagacctctt  254761 tgaatttaga gttttctagt tcaaaagata tcttctaccc cttacacctt gccacctctc  254821 tgtactgtgc ttctccttac gtaggccaag gtgttcctcc caccaatctt atatactgtg  254881 ttgagtaccc attagttatt cctattggat ggatggagaa attaaggctc agcagagttt  254941 gaggatttca ctaagttcaa atgcccagta atttgcataa ctgaactttg aacaccttgc  255001 tttaatttca gcacttagct tttctaattt ctgatgtgga ttcatctata ttgatgataa  255061 caatcatcaa tatagactga tgtctctgtc tcgtcctggg tagccttttt atttttaaaa  255121 attctgtatt aaaatagttt cttgtctgtt gttaaattcc cttagagttt tatggccttg  255181 atgtgactca tgtgaccaaa cgttttgtta aaaaaaaaat taaacttatc aaaaccaagt  255241 ccttgttcta caagactctt gcatattcca agataaatca tggccagctt cacacacacc  255301 atttctaaat caacgagact ttattttctt ccttctactt agatgtcagt gcctttgtcc  255361 attttctttt cacttctttg gtacatgttt acccagacag ttatgaccta cctgatactc  255421 tgcctaaata tcttccatgt ctcttgacat ccttaatttc ttaacattga aattgtttct  255481 ttttcctccc cattttccca cccccaatta atttttttct ttgtcgaagg aatttctcct  255541 tatctattta gtagaaagca gtcagagtgc ctcatagacc ccagtctaat attttacttc  255601 tcagagatat tttcattgga gatcataatg tttgatgtat gtaatgatga atttcagacc  255661 ctagagaaag ttatggaagg gtaagtggac ctggcctaca gggcatgata ttctggcaaa  255721 tcccacaaaa catatggtta tctcatcttc ctcaaactat agttgacctt atttcaaaaa  255781 tgcttggagc agaaaagcaa cgaggtatga aagacatgaa gtcaccacct tccattttat  255841 attactactc tatgaattgc atctagattt taaaactcaa cataaaaaac tgtcttcttg  255901 caagcatgga ctaataagga tagtagtagt tcacaaagaa tggcagctat ttacaaagtg  255961 aggtgatatt gtcaaaacct atcataatga caaagacaga actaaacagt gatagaataa  256021 caagcatatg tggtatgcat ttattatatg tattgtgcca tgcaaaaaag caatttatgc  256081 tgtatgtatt tacttggtga ggctctttcc agtgctaagt ttacttctag aatgacaatt  256141 catgtattca ttcatttgat tactatttgt ggaacaccta gaatgggtaa tctaagagaa  256201 ctatccagta cctgggtatt tcatggtgag caaaataaag tccttgcctc tgtggtgctc  256261 agttggggaa atattgtaaa caaagaaatg accagtggtt ttggccaatg tagtataatt  256321 ttatgttgtt gttatcctct gcagtcaaat atttgctaca gcttcttcat cctcaagaat  256381 tttaaatagt tgagaagagc caagatggct aacaagatgc agccaggaag agcttctccc  256441 aatgagaaac cagggtatta agaagattgg cacactccaa gtagatcttc agaagggagg  256501 cattgagagt ggatggagga aggatgtaga ctctgtgctg aagttagagg aagcttggaa  256561 tgctatgctc aggaatgagt tctaggactc attcctggct ccgagtgtct cctaaggaag  256621 ggagagttaa ataggcgtgg agtagcccac tctcaccatg gacctccata attctagctg  256681 caggagtctc aatgaccccc atggatattt gaactgatag ggggagctgc ttgaagagtt  256741 gacagggaca ggactgcaga ctgtgtggag ttcagaggat ttggcaaagg aaggactgca  256801 gtagagcaca gccaaggaca cccatccctg aagactcacc atgcccctgt aggctttggc  256861 ctttgttgac tgtcagacca atacagagca gggctgtctt gcccatggaa tgaggccatt  256921 ctgatctgag tgcctccctt gtctgccagc ctttcctgag gttcatgcca ggctgtgccc  256981 acttgcagca caggcttgga tgtccaactg gggcacttcc taaaggccat catcatagct  257041 tctttgttgg cagaccccac ccaactgttg gagagcttct gaagacaagc ctccacccgc  257101 acacaaccac ctgcagcctc ccccctctgc tttgccaaca cgcaggtatg catggaccct  257161 gctgctctgc tgccaccaac acatgagcac agaccccact gccactgccc cgacaaagca  257221 ctgttgccag caaccctcat ggagcattgt tgttaacaga ctggaaacac ctcagctcct  257281 tcagcacagc aggtgtttaa ccttgagagg ccagagaaca aagcbgtgtg cctggtccta  257341 taccactggg ttacagcaca cagtccagga gtgctgagct gagcccaggt cccctgaaat  257401 cagccagaaa tgaagccagt tgactagacc taacttatat cacagtcaaa acctcaaagg  257461 catcaaagaa ttgcaacttt aaagattaaa gaaacatcag ctcacacaga tgagaaaaaa  257521 ccagcaaaag aactggggca actcaaaaag ccggagtgtg ttctcacttc caaatgacca  257581 tgctagctcc ccagcaatgg ttcttaatca gactgagatg gctgaaatga cagacataga  257641 attcagagtc tggatggcaa tgaagattgt tgagatttag taggaagtta aaacccaata  257701 cgatgaacct aagaatccag taaaacaata caagagctga aagacaaaat agtcatttta  257761 agaaccaagc tgatctgata gagctgaaaa ccccattaca ataatttcat aatacaattg  257821 gaagtatcag gagcagaaca gcccaagctg aggaaagaat ctcagagctc aaaagtggtt  257881 cttcaaattg actcagtcag acaagaataa aaaagaaaga ataaaaagga atgaacaaag  257941 cctccaagaa atacagaatt atgtaaaaag accaatccta tgactcactg acatccctga  258001 aagagagggg gagagagaaa gcaagttaga caacatattt gagggtactg cctatgaaaa  258061 tttccccatc ctcactagag aggtcaacat tcagattcag aaaattcaga gaacccctgc  258121 aagatcctat aaaagatgac catccccaag acacatagcc cacagattct ttaaggtcaa  258181 tgcaaaagaa aaaatattaa aggcagctgg agagaaggga aagacatcta taaaaagaac  258241 ccatcacact aatggcagac ctttcagcag aagcagtaca accaagaaga gattagggcc  258301 tatattcacc atcctaaaag aaaagaaatt tcaactaaga atttcatatc gagcctaact  258361 aagcttcata agcaaaggag aaataaaatc cttttcagac atgcaaatgc taaaggaatt  258421 cattactatc acacttgcct tacaagaggt ccttaaggaa gtgctaacat ggaaataaaa  258481 aactgttacc aactaccaca aaaacacaca taagtacata gaccactgac actataaagc  258541 aactacacaa tcaagtccac ataacaacca actaacaaca ctatgacagg atcaaatctt  258601 cacatatgaa tattaacctt aaatgtaaac gggctaaatg ccacattcaa aaggcacaga  258661 atggcaagtt ggatcaagaa gcaagaacca actgtatgtt gtcttcaagg gacccatctc  258721 acatgcagtg acacccacag gctcaaaata aagagattga taaaaatcca tcaagccata  258781 aagagattga taaaaatcta tcaagccata aagaaattga taaaaatcta tcaagcaaac  258841 agaaaacaaa aagagaagag cctgttattt ttattttaaa ccaaacagac tttaacctaa  258901 caataatcaa aaagggacaa agaagaggat tacataaaga taaaagattc aattcagcaa  258961 gaagacttaa ctgtcctaaa tgtatatgta cccaacactg gaacacccag gttcataaaa  259021 taagttcttg acccacaaaa agacttagat aactacacaa taatagcaag agagttctgc  259081 accttactga cagtattaga cagattattg aggcagaaaa ctaacaaagg tatttgggac  259141 ctgaactcaa cacatgacca aatggaccta acagacatct acagaacact ccacccaaca  259201 acaacagaat atacattctt cttatctgca aatgacacaa actataaaat caaccacatg  259261 ctcactcata aagcaattct cagcaaatta agaaaaactg aagtcacacc aacaacattc  259321 ttggatcaca gtgcaataaa aatagaaatc aataccaaga ggatctctaa aaatcacatg  259381 attacatgga aattaaatag cctgctcctg aatgactttt gggtaaacaa tgaaattaag  259441 gcaaaaatta agaaattatt tgaaactagt gagaacaaag acatgacata ccagaatctt  259501 tgggacccag ttaaagcagt ttaaaaggga agttatagca ctaaacaccc acatcaaaaa  259561 gttagaaaga tctcaaatta acaacttaac atcacatgta gagaaaccag agaaacaaga  259621 gcacaccaac cccaaagcta gcagaagata agaaataacc aaaatcagac ctgaactgaa  259681 tgaaattgag acacaaaaag ccatacaaaa ggtacataaa tccaagagtt gtctatttga  259741 aagtataaat aagattgata gaccactagc tagattaata aagaaaaaag aagattcaaa  259801 taaacacaat cagaaatgac aaaagggaca ttaccaacaa ctcaaaagaa acacaaaaaa  259861 ccctcagaga ttattacaaa cacctctatg cacacaaact agaacactta gaagaaatgg  259921 ataaattcct gaaaacatat aacctcccaa gattgaacca ggaagaaatt gaaaccctga  259981 acagaccaat aacaaattct agaattgaat cagtaataaa aagcctatca accagaaaaa  260041 gtcctggacc agacaaattc acagccaaat tctaccagat gtataaagaa gagttggtgc  260101 caatcctact gaaactattt caaaaacttg aggaggaggg atgcctcttt aactcattcc  260161 atgagaccag catcattctg ataccaaatc ctggcagaga cacaatgaga aaataaaact  260221 tcaggccaat atccttgata aacatacatg caaaaatcct caacaaaata atagcaaacc  260281 aaatccacca gcactcccaa aagtaattta ccatgatcaa gtaggcttta ttcctgggat  260341 gcaaggttgg ttcaacatac acaaataaat aaatgtgatt tatcacataa acagaatgaa  260401 aaacagaaac tacgtgatca tctcaataga cgcagaaaag gctttggata aaattcaaca  260461 tcctttcatg ttaaaaactc tgaacaaact aggcattgaa ggaacatacc tcaaaataat  260521 gagccatcta tgttaaactc acagccaaca tcatactgaa caggcaaaag ctggaagcat  260581 tatccttgag aactggaaca agacaaggat acccaccctc actattctta ttcaacatag  260641 tacgggaagt cctagccaga gcaattaggc aagagaaaga aataaaaggc acgcaaatag  260701 gaagagagga agtcaaacta tctctctttg tggacaatat aattctaaac ctagaaaacc  260761 acatagtctc tgcccaaagg ttcctagatc tgataaataa cttctgcaaa gtttcagaat  260821 aaaaaaccaa tgtacatttc tatacagcaa tattgtccaa gccaaaccag gaatgcaatt  260881 tcattcataa tagccacaaa aagaatataa tatctaggaa tatagctaac cagggaggtg  260941 aaagatctct acaatgagaa ttacagaaca tagcttaaag aaatcagaaa tgacacaaac  261001 aaatggaaaa attccatgct catagatggg aagaattaat attgttaaaa tggccatatt  261061 acccaaaaca ctttacagat tcaatgctat tcctatcaaa atacaaataa cagtttttag  261121 agttagaaga aactatttaa cattcatatg gaacccaaac accctgaata tccaaagcta  261181 tcacaagcta aaaattaaaa aaaatttaaa aagctggagg catcagaatc acactacctg  261241 acttcagact atgctacaag gctacagtaa ctaaaatctc atgatactga tagaaaaaca  261301 ggcacataga ccgtattagt cagggctctc tagagagaca gaactaatag gagatatata  261361 tatatatatg ggagcttatt agggagaaag gctcacatga tcacaaggtg aagtttcgtg  261421 ttaggccgtc tgcaagctga ggaaggaaga agccaagagt ggctcagtct gagtccaaaa  261481 gcctctaaaa cagggaaacc gacagtgtag ccttcaatct gtggctgaag gcctgagagc  261541 ccctggcaaa ccactggtgt aagtcccaga gtccagatgc tgaagaacct ggagtctgat  261601 atccaagagc aggaggatga aaggaagcat ctagtacagc aaaaagatga aagccagaag  261661 actcagcaag ccagcttacc ccactttctt ccacctcctt tgttttagcc actgtggcag  261721 ctgattagat gatgcccacc cacattaagg gtgggtcttc ccctcccagt ccactgactc  261781 aactgtcagt ctcctctggc aacaccttca cagacacacc aagaaacaat attttaccag  261841 ctatctaggc atccttcaat ccaatcaagt tgacacctaa tattaaccac cacatagacc  261901 aatggaataa gttagagaat ctagaaataa agctgcacat gtacaagaac ctgatttttg  261961 acaaagttaa caaaaacaag caatggggaa aggactccct gggtcataca cagcattgga  262021 ataactggat agccctatcc agaagatcaa agctggactc tttcctttca ccagatacaa  262081 aaatcaactc aaggtgggtt aaagacttaa atgtaaaatc gaaaactata aatttttagt  262141 ttttaaaact aatctataaa aactcttgaa gaaatcctag gaaatactat tctggatatc  262201 ggccctggca aatccttcat taagaagact ccaaaagcaa ttgcaataaa aaccaaaatt  262261 gataggtggg acctaattaa actaaagaac ttctgcacag caaaagaatt tatcaacaga  262321 ctaaacagac aaccaacaga atgagaaaaa tatttgcaaa ctatgcatcc aagaaaagtc  262381 taatatccag aatctataag gaacttaaac taaccagcaa aaacaaaaca aaacaaaacc  262441 ctaaaaaacc attaaaatgg gcaaaagaca tgaacagaca cttctcaaaa gaaggcacac  262501 acggccatta agcatataaa gaattactca acattactaa tcattagaga aatgcaaagt  262561 aaagccacaa tgagatacta tctcacacca gtcaaaatga ctattgttaa aaacaaacaa  262621 acaaacaaac aaacaaaaaa cagatgctgg catgactgtg gagaaaaggg aacacttaga  262681 tgctgttggt gggaatgtaa attagttcag ccactgtggc aagcaatttg aaaatttctc  262741 aaagaactca aaacagaact accatttagc caagcaatcc aattactggg taaatatcaa  262801 aggagtagaa atcattgtac tataaagaca catgtactca tatgttcacc acagcactat  262861 tcaaaacagc aaaaacatgg catcaaccta gatgtccgtc aacagtgtac tggatgaaga  262921 aaatgtagta tatatacacc atgcaatgct atgcagccat aaaaaagaat taaattatgt  262981 ctttgcagca acattgatga agctggaggc cattatccta agtgaattaa tgcaggaaca  263041 gaaaaccaaa taacctcata ttctcacttg taaatggaag ctaaacattg agtacacatg  263101 gatgcaaaga agagaacaat agacaccagg gcctatgtga gggtggagag tgggagcaag  263161 gtgaggattg aaaaactacc tattggttac tacgctcatc atctgagtaa tgaaataatt  263221 gatacaccaa acccccacaa catgcaattt acccatgtaa gcaacctgca catgcattcc  263281 ctgaacctaa aataaaaatt agaaagaaaa aaataataat taaaaaaatt atctggggga  263341 aaaataattt acattagtag caccctcttg tcttcagggg atatgttcta agacccccag  263401 tggatgccta aaactaagga tagcaaattc tattgcbgtc agttggaaca tgtttctttt  263461 catgtcttca gtccacatat ttaatgactt ttccacttta actaaatttt aatcacacac  263521 tgtgaccatc acttttacag tttgaggtac aacagcaaaa ctatcattaa tttctttttt  263581 cttcttcaca atttcatgga tagaagattt gttcttactg tagatcttag caacctcagt  263641 gtatgatttt cttttccttc cttattaggt caaaaacttt tgccttttca cttaaaggaa  263701 gcactttaag tcttatctgt ggcatatctg aattgccagc atcactgctc ttgcactttg  263761 agagtattac atgaaataag ggttacttga acccaagcat tgccttactg taatagtaag  263821 tctgataact gagaggacta ttaacaacat gggtatacta ttgtatccac aggatgcatc  263881 cacactaaac aaagggagaa ttcacatcct gggcagggtg aagtgggaag gtgaggaatt  263941 tcatcacagt actcgaaaca tcataaaact taaaacatga attgtttatt tctagaattt  264001 tccatttaat atttttggaa ccatgaattg atcacaagta actaaaacca tggaaaagag  264061 agaactagtc cacatgttgt ttagtatcgc tattacagta attttctttt tcttgtgtgg  264121 tcttatcctg tgggcttcta gaaaattgtt tcctacctgc ctctcaatcc ccttcctctt  264181 ctcaactttc attttagcag aggctacatt atagtgaccc tgttggttta ggatttaaag  264241 aggcatttat ttgatttgtt aaaaacctcc acatgcaccc atgaaataac caaatgacct  264301 cagggtataa atggagctgc aaacttgtcc aagtcaagaa attcagtata aaaaccttag  264361 gcaggccagg cgcggtggct cacgcctgta atcctagcac tttgggaggc cgaggtgggt  264421 ggatcacgag gcagaatatc gagacaatcc tggctaacat ggtgaaacct cgtctctact  264481 aaaaatacaa aaaattagcc aggcatggtg gcgggcgcct gtagtcccag ctactcagga  264541 ggctgaggca ggagaatggc gtgatcccgg gaggcggagc ttgcattgag ccgagatcgc  264601 gccactgcac tctagcctgg gcgacagaga agactcctcc tcaaacaaaa acaaaacaaa  264661 aacaaaaaca aaacaaacaa aaagaaacac cttaggcaac aacatatatg ctagaattgc  264721 ctttgctaac tcccctggca aagcaaatga tgtattgaga ttgcttctca gataaggtgg  264781 ttgaaaatga tagcaatctt aaaaaatgag cagttttcat aaatttgtat acattttgct  264841 ctatagacaa agagtagagc ttatagctat catggccata tctcaataaa aatgtgttgc  264901 aagcaggttt gccttgggca tctttcctta ttcctttcag tattccactt cttttcacac  264961 cctttcccac atgttagatg ttcccagtct gctcattcag ttcgggctcc cttccctggg  265021 aggcbgtctt cagctcaaaa ctttgccagt gataaaactc cattcaaaac ttatctgcca  265081 agtggccatt tttacttgaa gccctgccct tggtcaatga cagtgcaaaa actggatagt  265141 ggcatattaa tcaaataagt cattttctcc ctaggttaaa ccatagggaa tatctgcttt  265201 caaccctttt ggcctccaaa aaaaaaaaaa aaagcatttt gtatggcttt tcatacctca  265261 tggtgtccta gcttgagcac tggagcaaag tcagaaaatc tgagcccttg acttatctct  265321 gtggttcact gctggataat gtccagaaaa ttatttcatg cctttgagct tcagcttcct  265381 tatctgtaaa aaggagagta actaccttga cttcttgctg agattttaaa gagaacaaat  265441 gtgaaagcac acacaatcac catttgcaaa gggtaaagtg gtagatggat gaaaggaata  265501 atgatctgta atttttcctt acatgctagc ctatttaaaa tgtatgagcc tccatgataa  265561 gtgtggctaa tagtggggga atgtagatga tctagagata ccggtcaacc tacaatgtca  265621 gctttatgtc attgtgcccc tttcttcttt ggggtttata tgactataat attttaaaaa  265681 ccaaaacctt atgggaccat tttataattt gtgtcatatg aaattttaat tttgctattt  265741 atagtgaaag ggaaaaaagg aagtggagta tataggatat agatctctaa ccactaaaat  265801 aaacctgtga gtaaatgcat tttaagctct tcatgcaaat acatatatat atatatatac  265861 acacatatat atacacacac acacatataa ttactgatta aaaatatata taaaatcaca  265921 tatatataca tataaaacca cttggcattc aggttgtata aaaatgttga tttttattca  265981 agaattgtag agtagatgga aatttaatgt actcaatgta atctctattt gggatgagat  266041 tctaggggga attaaaattt acataggagt ttctttgcct ggtttagtcc atccagaggc  266101 ttcagatggt ctgggaacca actaaagttg tgtggagcaa tgtaaaagtc agtatatatg  266161 tttcttttcc cctggggagg gattcaatag atttcatcgt attcttaaag aaattcttgt  266221 cctaccaaag gttaagaact aattatctca gttaaacaaa acacataaaa atatgttttt  266281 atatacatgt tgaattattc aaatcttcag tgcttagtag tttattaatc ttgaaggcct  266341 agaaagtgaa taatttcaac aactgaacaa aaataaaatt taaaaagaaa ctattttctg  266401 gtcattagaa caaacttgtt ataaaatata tgtctttttg ctattgcttc tccacttcaa  266461 cactcatgat catgttttgt tgctatttcc cctatctcat tttttctggc tgctgggtta  266521 aacttcctgt ttttgcagaa tgaccaaaaa cattggtgat gatggaggtg gagatgacaa  266581 cactttcaat ttcagctgga aggtctttac cagcbgggac tacctgatcg gcaatcctga  266641 aacagcagac aacaaattta attctatcac aatgaacttt aaggtagagg caccaacttc  266701 aaaaacctgc tgtttgtatt tctaagagta aaattggagg cattccatct ggtccagtag  266761 tgcagtatct tgacaattta catgaaagat taactcatgg tttctgccta ccaagatctt  266821 gccatggttc tgattataac tggaaaatct tccatgaccc acaacagcac tattattcct  266881 taaacacttc tcttctctaa atctggtaat aaaataatgt tactggattg aaataggacc  266941 atgagtaatc agaataagat attttaaaaa ctagaacaat gttcactaat tatttacagg  267001 aataagcata atattgaagt gaccctaaaa cattattttg tagttttttt tttaattcac  267061 tggaatgaag atttttagag tgaagactat cctaatatca gagcaatcac agtttgtttg  267121 caagaattct tccttctgtc ttacttgcca tcgtttgttg gcaatattca cctggtttgt  267181 ggaatctcag atttagttta cattgtcatt cctcacattc tgatgattgt aaaaataact  267241 tttgaggttt tgatactttt aaaatgtagc taagatattc tattttgggt ttttgtttgt  267301 ttgtttgttt tcatggatac aggaagctat cacagaagaa aaagcagccc aagtagaaga  267361 aaacgtccac ttgatcagat tcctgaggtt tctggctaac ttcttcgtgt ttctaacact  267421 tggagggagt ggatacctca tcttttgggc tgtgaagcga tcccaggaat ttgcacagca  267481 agatcctgac acccttgggt ggtgggaaaa aaatgaagtt cgtctctgca tgctttttat  267541 gtgcttagaa cctgacattt gtttcttttg tgggttatgt ttctttgatg gaacatttaa  267601 aaaggccacc ctttacctat cccctatcct gcccttacag ttaaccaacc ctgttgctca  267661 ttttccattc tattctagtc ttatttctaa atctggactg tctgtttttc attttgtgac  267721 atgatggaaa gttagagtca gaaaagatat taaaaaacac atagtctaat cattatgttt  267781 tacagatggg aatgataaat ctcaagagat tgcattatat gtttatggtc acagagttag  267841 gagaagagtc agggtgagaa cctaggaatc ttgacttcga gtccaaggct cttgctgctt  267901 tctctgcaaa tccttcatct gtcattaaaa gatcaaattg ttgcctgaac tttttgaagc  267961 agccatgata aagccactga ttcctatgtt gatctcactg gaaacactca gattgcttct  268021 ccacctttgg gcatgtctgg gcttccctct gttttcatta gaagcctaac tgcagcatct  268081 ccatctccat ttcctcctgt cctgtacctt actttctctc cctctaaatg ctattcaaat  268141 gaagaaggcc agctcttttc caggaattaa acattatgac cgtaatttgc ctttagagta  268201 tctgcccatt tagtgaatca gagaaaggag gttagacata gatcatttag aatcagaaaa  268261 tcattggtca tgagttgttg ctagagtctg ttcccgttca taaaatgctt atgtgtatga  268321 tgtgacgtca ttttgagctt gggcattttc aaagtatgtg cagatttagg ctgtgggaag  268381 tgtagacttc ccacactgaa acttttgcag aacagtatag atcaaaagaa ttaaaatatg  268441 tctttataag catagaattt tctaaaaaat cttggacagc aaatgatata atctacttac  268501 agaaaaaggt tccaaataac attctgagta tttcagaagt ggtaccaata gagacgggac  268561 tagatatttt aaagacttta atatacagtc atgtcataaa aacttgtaaa atataagtaa  268621 tttagcagag ggcttttatt tatttaaaat gaaaaatgta ggaacacctc aaagcattta  268681 ctaagtttgc tttcaaaatg gtctcataat tgtaatagta catagaggta acattatcat  268741 gcagctttgg tccattattt atattggtta tgtttttgta taaataaacc atattaaagg  268801 atgggtagtt gattatcaat aaaataacta ttctttgtaa gaacctcttt aacatatatt  268861 ttagggaccc tctgagtcct aggggccaat gaaggtaata atggagattc atgagtaact  268921 ttacaaattt gataaaacca aatttaaatt tgccttgcat aagtttgcac aggataagcc  268981 aaattttctt tacattagtc taaaattata gcatgctgat tttgtattat gtcatgctga  269041 gatttggatc ctgttggtca tacttatata atgttttaat aaaaatgaca aaaatctaat  269101 agcaattgtt ttctaaatat agtctggtag ttattataat tattcacacc acgaagtcca  269161 caggagaaaa taggaaatgt ttagtggtga cagtttgagc cgggtatttg ggaaaggaga  269221 tagtcaccag agttacctaa aatcggtatt tccctattag aaaattagta catgttttgg  269281 attcttttta ttgacttcct ttagccaaat aatatcatca taaggttgcc aaacatccag  269341 gaaataaaaa gcacatgttt cctacttttc atgtttctat tccttcttct ttctctctcc  269401 cccctctccc cacccctgca ttattctctt gtctctgaaa ttatagccca ttctttcact  269461 tttgaaactt ttctacgttg gcttccataa cattatgtca tgtgttctcc atttgtttct  269521 ctgagttcct tctgtttcct ttaataaaac tcattgtatg tgtttatgtt ttcggcctta  269581 aaagtttaca tttgccaaaa ttcaatattt aggcctaggc ccatctcagg gaattcatcc  269641 attctaactg attaaactag cccatatgct gatgattgtc agattagaat tttcagtttg  269701 aacctcctcc tcaagcagat tattttccat ttcttttgga aatcttgttg tgaagtgcat  269761 caccatatca gaatcagtta ccacatagaa caatatgtgt tctctgtgta gagactgatg  269821 taaattgcca ccttcactat accaggaaac agactgttac tactggcaca tacacacact  269881 cagtcacatg cctctcttga gaatgtgaat tgaatatttt ccctgtcatt ttattgagat  269941 caaattctaa acgtgcataa aatagtcatt tttagtctta aaaaagatca aagaagccta  270001 gctcagaatc ttccaaaatt ctggcaaaaa gcaataataa ctttaaacac cattaaccta  270061 gtttctccct tgtgcctcct tgtagatgaa catggttatg tccctcctag ggatgttctg  270121 tccaacattg tttgacttat ttgctgaatt agaagactac catcctctca tcgctttgaa  270181 atggctactg ggacgcattt ttgctcttct tttaggcaat ttatacgtat ttattcttgc  270241 attaatggat gagattaaca acaaggtaag ccttgtttct ggattgtcct tgccataaga  270301 gtgttgttca attcccagtc tcaagtttgc cagaaatgcc tttgaaatct ctgttgtctt  270361 cattttagtt tctatctctt tgctttctag attgaagagg agaagctagt aaaggccaat  270421 attacccttt gggaagccaa tatgatcaag gcctacaatg catcattctc tgaaaatagc  270481 actggaccac ccttttttgt tcaccctgca gatgtacctc gaggaccttg ctgggaaaca  270541 atggtgggac aggtaatgcc accaacagaa gtgtatggca attagtagat taaaaaaaga  270601 gagtcaatat ctcttccata agattggctt ttaaaaaatt gcttattagt aaaaatagct  270661 aagatttgtt gaatgttgac tgtgtgctgg ctctgaattt catgtatatt atctcacact  270721 gtttgcaaat ctatcccttg aggtaaatac tatttgtatg tcccctttac agttgcatat  270781 aaaggaagga tagttgaaaa tggtgcaaag agatgtttac tatctgtatt ataataaagc  270841 actcgattta gatacaggcc aaagcaaata tttaaatgga actctattta gtgttacttg  270901 tttgctgtaa aacaaaacaa aacaaaacaa acaaacaaac aaaaacagag tcttgggggt  270961 ggccaagaca gccaactaga ggcagctagt gtgcatggct ctcatggaga gaaatagagg  271021 ggttgagtaa atatagcacc ttcaaccgaa acatccaggt acatgcattg gatctaatca  271081 aggaaacaac ttgacccatg gagagcagag aaaagcaagg cagggtgaca gcccacctgg  271141 tagtgacatg aagccaaggg atccttctat gcccagggaa gtggtgagtg aatgcacgac  271201 cttgggaacc catacttctc ccgtggatct ttggaaccct tgtgtcagga gatatcctca  271261 tgaacccact ccacctgggc cttcagtccg acacacagag ctatgtggag tctcagcaga  271321 gcagccactt aagcacatgc agagacccgg gagccttaga tacctgggct tttctttttg  271381 ggcttcctgt caaaagtagc tatacctctg gcaaagcagg aggttagacc cccaaccaca  271441 ccccttagaa aaggggctga atccagtgac agtctgcagg ccccacttca cagcacctca  271501 cagaatgaaa cccactggct tggaactcca gccagttacc ggtagaaatg ttgcacctcc  271561 ctgagacaga gctcctgggg gaaagtgtgg gccatcatct ttgctgtttg gttgacttgg  271621 ccattccatc attcaggctt cagagagtcc aagccaacca gcggctgaag cagaccctga  271681 gcacagcata gcbgttctat gaaaatgtgg ctagactact ttttcaaatg ggtctcctat  271741 ccctttcctc ctcactgggt aggacctcct aactggggtc tccaaccacc tcctacaggt  271801 gcgtttgggc cagcaacggg tctgtacatt tctgggatgg agcttccaga ggtgggggca  271861 ggctgccatc tttgctgttt cacagccttc actgttgcta cctccagata ataaaacatc  271921 tgaggtgacc agggacggat gtggggtccc aatatactgc agcagcccta tgaaaaagtg  271981 accagacttt tacatgggtg cccatcccca tatcggctca ccagacacat cctccaggcc  272041 taggcctcca gctaccctct gctagaatta tcgatcaagt agcagctctg taactccctg  272101 gacaggatcc ccaggggcaa ctgaaagttc ctctgccact acctctgcag tagaactgcc  272161 cttgctaccc ttggactaac aaaggaacaa agaccctaag cgcctcatcc atacctccaa  272221 taagctgcag ttgactccag gagagaaggc cagtctgtct ctcacaggtc ctacctaccc  272281 ccacccccct ccttgtcacc agacagggaa cccccagctc ggacccacaa catagaacat  272341 ccatcctggg ctaattgcaa ggagtaattg ctgacctgca tctcaatggg gtggagcccc  272401 caggagataa gcaaaagacc cttggccata accatgccaa ggtatcttcc tctgctgctg  272461 ccaagttgga gaagaaacat aacgctgaga ttgccccaga gctgaagggg cagcccagga  272521 gtgccaagcc gtaatctaca gccagctctc aagggggaaa gaaatctaca ctttcagagc  272581 attgagaggg aacatggctg caactgtgcg gcaacacagg ggagcctcac aaccaagcaa  272641 gagtctacca actgaccaat atgccgaagt gccacctact ggatcacatt ccccaaagca  272701 tcaacaccaa aaatatctca ctaacatacc cccctctgaa accaaagaca agtactcagc  272761 ttcaaataaa gaccctgtgc aaagccttgg cccaatgaaa acttccagga aagatgccta  272821 ttgactgtat tcaatctaca ttgcagttaa aggaacacct acacactgag atgagaaaga  272881 accaatgcaa gaactctggt aactcaaatg accagagtat tgtatgtcct ccaaacaacc  272941 acaccagttc tccaacaaga gttcttaacg aggctgagct agctgaaatg actgaaatag  273001 aattcagact gtggagagga atgaagatca ttgagattca gaagaatggc aaaacccaat  273061 ccaaggaaaa taagaatcac aataacacga cactggagct gaaggacaaa gtagctgtta  273121 taaaaaagaa gctaataggt ctcataaggc tgaataacac aatacaggaa tttcacaatg  273181 caatcacaag cattaacagt agaataaacc aagctgagga aagaatctta gaacttgaag  273241 actggctctc tgaaataaga cagtcagata aaaataaagg aaaaagaata aaacgggaag  273301 aacaaaacct ccaagaagta tgggattatg taaatgccaa agctatgaat cactggcatc  273361 cctgaaaggg atggggaaaa agcaaacaac ttggaaaaca tattttagga tattatccat  273421 gaaaacttcc ccaaccttac tagagaggca aatttgctgc cagtctttgc taacagtcaa  273481 atttaggaaa tacagagaat tcctgcaaga ttctacacag gaagatcatc cccaaaacac  273541 acaattgtca ggttttctca ggtcaaaatg aaaaaatgtt aaagacagcc agagagaaag  273601 ggcaggtcac ctacagagag aacaccatta ggctaacagc agatgtctca gctgaaaccc  273661 tacaagccag aagcagtcag ggtcctatat tcaacattct taaagaaaaa aaatcttcaa  273721 ccaagaattt catatcaggc caaactaagc ttcctaagca aaggagaaat aagataattt  273781 ttgggcaagc aaatgttgag ggagtttgtt accaccagac ctgctttaca agacatcttg  273841 aaaggagcac taaatggagt aaggaaagac tatttgcagc taatacaaaa gcatacttaa  273901 atacacagac cagtgacact gtaaagcaac catacaaaca agccagcata ataatcagtg  273961 aacaacacaa tgacaggatt aaatccatac atattaatac taatcttgaa tgtaaatggg  274021 ctaaatgctc catttaaaag gcacagagta gcaagctgta ttaaaaaaaa agcaagaccc  274081 aatggtatgc tgtcttcaag agacccatct catgcttaat aacacccaca cgctaaaaat  274141 aaagggatgg aagaaaatct accaaccaag agaaaacaga aaaaaacatg ggttattgaa  274201 attaaaattc ccaatttcaa aaaaaaaatg caaaaaacaa aacacacaca tgcacacaca  274261 aatacacttc aaaccaacaa agataaaaaa aaggcaaaga agggcattac ataatggtaa  274321 agggttcaat gcaacaagaa gacctaacta tcctaaatat atatgcactc aatacaagag  274381 tacccagatt cataaagcaa gttcttagag acctacaaag agacataggc taccaccacc  274441 caataatagc ccaggccctg atgaattcac agctgaattc taccagatgt acaaagaaga  274501 actggtaaca ttcctactga agctatttca cgaaattgag gaggaggagg aacttcttcc  274561 cagctcatcc tatgaggcca gtatcattct gctaccaaaa cctggcagag acacaacaaa  274621 aaaagaaatc ttcaggccaa tatcatgagg cccatcaatt caaaaatctt caacaaaata  274681 cttgcaaacc gaattcagca gcacatcaaa tggctaatcc accacaatca agtaggcgtc  274741 atccttggga tggaaggtta gttcaacata tgcaaaacaa taaatgtgat tcatcatgta  274801 aaaagaaata aagagaaaaa ccacatgatt atctccatag atgcagaaaa agctttcaat  274861 aaaattcaac acccgttcat gttaaaaact ctcaataaac taggtattga aggaacatac  274921 ctcaaaataa taagagcctt ctatgacaaa cccacagcca aaatcataat gaacggacaa  274981 aagctgaaag cattcccctt gaaaaccagc acgagacaag gatgccctct ctcaccactc  275041 ctattcaaca tagtatttga agttctggcc agggcaatca ggcaagagaa agaaatgaag  275101 ggtatcaaaa taggaaaaga gggagtcaaa ttatctttgt ttgcagatga catgatccta  275161 tatctagaaa accccattac cccggcccaa aagcttctta agcggataag caacttcagc  275221 agtctcagga tatatcaatg tgcaaaattg ctcgcattct tatacaccaa caacaggcaa  275281 gcagagagcc aaatcatgaa tgaactcaca tctacaattg ctacaaagat aataaaatac  275341 ttaagaatgc agctaacaag ggaagtgaag gacctcttca tggagaacta caaactactg  275401 ctcaaggaaa tcagagagga cacacacaaa tgggaaaaca ttcaatgctc atacatggga  275461 agaatcaatt ttgttaaaat ggccatactg cccaaagtaa tttatagatt caatgctatt  275521 cccattaaac cacaactgaa attcttcaca gaattagaaa aaaactattt taaaattcct  275581 atggaaccaa aaaagagctc gtatagccaa gacaatccaa agaaaaaaga ataaagctgg  275641 aggaatcaca ctacctgact tcaaactata ctacagggcc acagtactca aaacagcatg  275701 gtactggtgc aagaacagac acatagacca atggaacaga atagataact tagaaataaa  275761 accacacaac tacaaccatc tgatctttga caaacctgac aaaaacaagc aatggggaaa  275821 atatttccta tttaataaat gttactggga gaactggtag ccatatgcag aaaattgaaa  275881 ctggacctct tctttacacc atgtataaaa attaactcaa gatggattaa aggcttaaat  275941 gtaaaaccca aaactatgaa aactctagga gaaaatctag gcaatatcat tcaggacata  276001 ggcacaagca aagatttcat gacaaaaatg ccagaagcga ttgcagtgaa agcaaaaatt  276061 aacaaatggg atctaactaa actaaagagc tccagcacag caaaagaaac tatcatcaga  276121 gtgaacagac aacctacaga atgggagaac atttttgcaa tctatccatc tgacaaaggt  276181 ctaatatgca gagtctacaa ggaaattaaa caaatttaca agaaaaaaac tggatcccat  276241 taaaaagtgg gcaaaggaca tgaacagaca cttctcaaaa gaagacatac atgcggcaaa  276301 caagcatgtg aaataaaact tcatatcact gatcattaga gaaatgcaaa tcaaaaccac  276361 aatgggatac cagctctcac cagtcagagt gattagtagt aaaaagtgaa aaaataatat  276421 gctggcaagg tcgcagagaa aaaggaacat ttatacactg ttagtgggaa tgtaaaatag  276481 ttcaaccatt gtggaaagca gtatggcgat tcctcaaaga gctaaaagca gaactatcat  276541 tcaacccagt catcccatta ctgggtatat acccagaggt atataaatca taaagacaca  276601 ggcatgtgaa tgttcattgc agcactattc acaatagcaa atacacggaa tcaacctaaa  276661 tgtccatcaa tgacagattg gatagggaaa atgtgatata ccatggaata ttatgcagcc  276721 ataaaaaaga atgagatcat gtctgttgca gaaaaatgga tctattatcc ttagcaaact  276781 catgtaggaa caccaaatac tgcatgttct tacttatatg ggagctaaat tatgataact  276841 catgaacgca aagaaggaaa caacagacac tggggtctac ttgagggtgg agggtgagag  276901 gagggagaag agcagaaaag ataactattg ggtactgggt ttaatacctg ggtgataaaa  276961 taatctgtac aacaaactcc catgacacaa atttacctat gtaacaaagc ttcacatgta  277021 ctactaaacc taaaataaaa gttttttttt aatggataat ttggggagca cacactaaga  277081 aattttaata atgtcaattt ttgttaaata attttccctt aaaagaaaaa aaatactatt  277141 ttaagttatt tgttttcatg atgattttgt aaataacccc agcccaagac tagccatacc  277201 ttaccagaga aaagaaataa tgtttcatat ggctttctat cccttaaggg aaaccaagac  277261 aaataaaacc aaacaaaacc caagaaaaat ctacttcaga tctcgtattt ttatacaaat  277321 ccaatttata ttttgaaaag cttttatgat ttcatttagt tagaattgat attcctaacg  277381 tgcagtccat aaattgattt tggggcttca gattatcatt gagaacagct tttgtcataa  277441 agcttctgta tgttagacaa cagttgagtt tagcactgaa tgtagtgttt gtgaaattat  277501 ttgaacaatt ttttactgca ttatttggta agataacata aaaattgaag gactagcatt  277561 agtcttataa aattcatata atttaaacaa atatgtaaaa atatatctta ggcttcaatc  277621 agatgctcat caaacttaag ccaatcaaga tttcaactgt gaaagaaaaa aataagataa  277681 atgtgtaaaa tgctagacat gtatcattaa tgattgagta caaaaattat ggtataattg  277741 aaaattctat tttattttat ttgttaagct ttcgggaacc agataaatcc cccctttgat  277801 gatatatgct attaatttga ttttcagaca tgcacatttc atacaactta caggaacata  277861 ttacatatga aataataaaa tcaaagtcat ctgcacttaa tacaggagtg cttgtgattc  277921 aggatgtggt agacagaata atggccctct ataacagtac acattctaat ctctggaacg  277981 ataaatatgt tacatggcaa aatggacttt gcagatgaaa ttaagttaaa gatctcagct  278041 tgaaagaatt attgtggatt atgtgagcag gcttaatgaa atcataagga tctttataag  278101 caggagataa agggaaaaag tcagaaaatt gagatgtaac agcagaagca gaggttggaa  278161 tgatgtgctt taaagatgga ggaaggagat taagagccaa ggaatgcagg tggcctcaga  278221 aactgaaaaa gaaaggaaac atattctctt cccaagtctg cactttgaat ttagacttct  278281 gacttccaga actgtaagaa gataaatttg cattgtttta aaccactaca tttatggcaa  278341 tttgttacag caacaatagg aaatgagtac atcatggtac ttgggtctcc ctgttccatg  278401 gctttttgaa gtgaagtctg gttgtggtgc ttaacacgag tctgttttat cacaactaag  278461 ccgctcccta aatcttcagc atacgattca agaaaggaaa atataggaag tacagtttta  278521 gaaactgaag gaatttgaga cgttctcttc tgcacatcct agaacacagg ttggcctgaa  278581 agctaagaaa cctgcacttt aacaagcaaa aacatctact gaatgggatt aatagaatta  278641 gctgtaaaga gtaggatctg ggctggccac ttctggagtg aaggaatgga ttaattagat  278701 aggaatgcga atgcaatcta ggagaatatt catgtttcag atgcagatgg ttctgcgata  278761 gtcccacaca tactgactta aaagagaaga aataccattt agttaatcct ccaccttgga  278821 agcccgtgga ttatgctgct tgtctttttt tttttttaaa cctgtctgta gtgattttcc  278881 ttgcttcatc atattttctt actgccattt tagttggatt tcccccttat ctttcacctt  278941 cctttctcca aggaagcatt aagctctagt gggaaagtct gcagaagcgg gccaagggaa  279001 aaggggttgt ggttctgact ggaatgttga ttaggcagat ggaatctctg ggaacaaaaa  279061 gaacatatag gacataacaa atctgagtgc tggcaaggtc tggcctttaa gagatcaata  279121 tctgtatcca tgcatctaaa atttctattc tttaattgct taaaaaatat gcctccaaaa  279181 atagtaaagg cagctgctct gtatgtaatg ttagatatgc accctcattc attgttctat  279241 gagagcatta cagatgtttc ctcttctcct ccatggatac cctctgcttt gattttctcc  279301 aaggatgcta tgagactcaa agcacttatt gttttgaata taggataatg tgattgctcc  279361 tttacttctg cagattccca agcaatcatt tagtttcatc cccaatggat ttgataggtg  279421 ggcagcagag ccattcctct ttgaagctat atcctgaggt cttcactttg gggaagggga  279481 gaaagcaaca gctgaagata aaatggctaa tgtgccaagt atttcctcct caaattttta  279541 cgtttcattc tgagatacgt tatattatta tttccgtttt atagatgaga agactgagac  279601 ttaggtaatt tgctcaagat ctctgagaaa gtcaatgaca ggagccccag ttcagcctac  279661 atagtctgct tacagagttt gtgtctttgt tcacagtgct aaattgtccc ccagttagca  279721 tcaacacaca ctccccaaac tcctgcctgc aatgtctata tttggtggcc ttttatgatg  279781 ttccttgcct attgttttcc cttcacctat taataaatta tttctttagc tttattgatc  279841 aaagctgccc aggcatttta actaacatca cgtgtgcaaa gtttttaggt gtggagtgtg  279901 gggtttagca ggaggcctgt gtgggggctg tgctccccat cctgacaagc acacaaggaa  279961 ctaggatgat atccttgaga ttggctgggc taccattgtt tggattctct ttcttttaaa  280021 atatattttt cctatggtat atgaataaac atttaaaatt tttaatacaa tgtttgaatc  280081 ttcttcagat attttatgtg aaagttaggt cactgcttgg gaaggaatag aatttcaacc  280141 tttgggatga ggatgcttaa gaggatgtgg aggacttcca aaccactctg aaatgttttc  280201 ttacctgagg aagtcttcta gacctggcag tagaaaccta aaaatatccc tcatagcctt  280261 cctctaattg atgctagtta ttagaatctg agctcaacat tgcctggaaa gggtgggcat  280321 ggaggcatgt gtctgtagtc ccagctactc aggtggctga gacaggagga ttgcttgagt  280381 ccaggagttc caggtcagcc tgggcaacat agcaagaccc ctgtctctac atacatacat  280441 acatacatac atatatacat acatacatac atacatacat acatacaaag aactgcctta  280501 ggaaaggaaa ggagacaaag agtaggaagg agaaaaatta tgtccaaaaa taaccacagg  280561 aatactatca ttcattcatt ttttatttat gagtgtacag aaattgctgg gcattgtgtg  280621 attatataat tggaagtaaa acacttctca gcaaatgcaa aataactgaa atcataacaa  280681 acagtatctc agacaacaga acaattagat tagaaatcaa aattaagaaa ctcactcaaa  280741 accacacaac tacatggaaa ttgaacaatt tgctcctgaa cgactcctga gtaaataatg  280801 gaatgaaggc agaaatcaag atgttccttg aaactaatga gaataaagag accatgtacc  280861 agaatctctg ggacatactt gaaggaactc ttcaaggaga actacaaacc actgctcagt  280921 gaaatcagag aggacacaaa catatgtgaa aacattccat gctcatggat aggaaaaatc  280981 aatattgtga aaacggccat actgcccaaa ataatttata gattcaatgc tatttccatt  281041 aaaccaccat tgacattctt cacagaatta gaaaaaaaac atttttaaat tcatatggaa  281101 ccaaaaaaga gtccttataa ctgagaaaat ccaaagcaaa tagaacaaaa caggaggtgt  281161 cacactacct gacttcaaac catactacaa ggctatagta atcaaaacag catagtactg  281221 gtgcaaaaac aggcagacag accagtggaa cagaataggg aacacagaaa taagatcaca  281281 gacctacagt catctgatct ttgacaaact tgacaaaaac aagcaatggg gaaaggattc  281341 gctatttaat aaatgatgct aagaaaactg gctagcctat gcagaaaatt gaaatgggac  281401 cccgtctata caccttatac aaaaattaac ttaggatgga ttaaatgctt atatataaaa  281461 gccaaaacta taaaaaccat agaagaaaat ctaggcaata ccatttagga cataggcatg  281521 ggcaaagatt tcaagacgaa aacatcaaaa gcaattgcaa caaaaacaaa aattgacaaa  281581 tgggaactaa ttaaactaaa gagcttctgt acagcaaaag aaactctcat cagagtgaac  281641 agacaaccta cagaatggga gaaaattttt gcaatctatc catttgacaa agatctaata  281701 tccagaatct acaaagaact taaacaaatt tacgagaaaa aaacatacaa ccccattaaa  281761 aagtgggtga aggacatgaa cagacacttc tcaaagaaga gattcacgtg gccaacaacc  281821 atatgaaaaa acactcaaca tcactgatga ttagagaaat gcaaatcaaa accacaatga  281881 gataccatct cacaccagtc agaatggtga ttattaaaaa gtcaggaaac aacagatgct  281941 ggtgaggctg cagagagata ggaaggcttt tacacagtta gtgggaatgt aaattaattc  282001 aaacattgtg gaagacagtg tggcaattcc ttaaagacct agaaccagaa ataccatttg  282061 acccagcaat cccattactg ggtacatacc caaaggaaaa taaatcattc tgttacaaag  282121 atacatgccc acgtatattc attgcagcac tattcacaat agcagagaca tggaatcaat  282181 ccaaatgcct atcaatgata gactggataa agaaaatgtg ctatatgtac accatagaat  282241 actacgcagc aataaaaagg aatgagatca tgtcctttgc agagacatgg atggagctga  282301 aagccattat cctcagcaca ctaacacagg aacagaaaac caaacaccat atgttctcac  282361 tcataagtga gagctgaaca gtgagaaaac atggacacag ggaggggaac aacacacact  282421 ggagcctggt cgggggtaag ggagaaatga gaacatcagg aaaaatagct aatgattgca  282481 ggacttaata attaggtgat ggattgatag gtgcagcaaa ccaccatggc atgtgtttac  282541 ctatgtaata aaactgcacg tgtaccccag aacttaaaat aaaaaaagaa gacataaaaa  282601 atttaaaaaa atacacaatt caatggtttc taatatattc acatagttat gcatccagca  282661 tcacgatagc attttgtttt aggggcttac aatataccat tgtgcagaca tttaatttgt  282721 tttatttaat tagtctccca agcatattca aatttttccg tttttaatct ggaagaagca  282781 gtactttcat gattgtatgt atagatttgt gcacatgtgc aaatattgct gtcataggca  282841 tttctaaaag tggattttct tgatcaagct ccaaacactt taaaatgtga tggatcttaa  282901 caaatttctt cccaacgttg tgcccggttt aacttcccca tcagtttatg ctcatgctag  282961 ttcaccacac tcaccaatat gaagaagcat ggattttaca tttgtcattc gtgaggcaac  283021 aactcattgt tttcatttgt atttttatta tgtggggttt cggtattttt caattttaac  283081 ggaccgtttg tatatgttct tctgtgaatt tttaatttgt gacttttgct ggtttctttc  283141 tttattggat tgccaatcta tattcatact gatttgtaaa atcttttaat gtgttagcaa  283201 tactcaccct ctatcatata cgttgcaagc actttttcca catttgtctt tcaagtctgt  283261 aaatagtgct attcaccaca taaaatttta aactgctgtg tggccaatat tttcctgttt  283321 ttggctctcg tatcatgttt atgaaatttc tcagtaagaa gaaaactttt gatttagtaa  283381 acgggaaata attatttttt aagtaataaa gtcagggtga aatatttttt atttacttga  283441 tatgactagt tgttttcttc ttttgccatt aattgcagtc ttcaagccaa tacttcttta  283501 gaaatatgac agatttaata ccaacactag gaccatttga agacagaact gtgtgtttta  283561 atagagataa tatctcaaca ggagtttgtg aggctgacag tctctgatgt tctgaccacc  283621 tacgtcacaa tcctcattgg ggactttcta agggcatgtt ttgtgaggtt ttgcaattat  283681 tgcbggtgct gggacttgga gtatggatat gtaagtatga tgttaatttt gctttttttt  283741 ttttttaaat ttatttattt tttattgata attcttgggt gtttctcaca gagggggatt  283801 tggcagggtc ataggacaat agtggaggga aggtcagcag ataaacaagt gaacaaaggt  283861 ctctggtttt cctaggcaga ggaccctgcg gccttccgca gtgtttgtgt ccctgggtac  283921 ttgagattag ggagtggtga tgactcttaa ggagcatgct gccttcaagc atctgtttaa  283981 caaagcacat cttgcaccac ccttaatcca tttaaccctg agtggacaca gcacatgttt  284041 cagagagcac agggttgggg gcaaggtcac agatcaacag gatcccacgg cagaagaagt  284101 tttcttagta cagaacaaaa tgaaaagtct cccatgtcta cttctttcta cacagacacg  284161 gcaaccatcc gatttctcaa tcttttcccc acctttcccg cctttctatt ccacaaagcc  284221 gccattgtca tccgggccca ttctcaatga gctgttgggc acacctccca gacggggtgg  284281 tggccgggca gaggggctcc tcacttccca gtaggggcgg ccgggcagag gcgcccctca  284341 cctcccgggc ggggcggctg gccgggcggg gggctgaccc cccacctccc ctcccggacg  284401 gggcggctgg ccgggcaggg ggctgaccac cccacctccc tcccggatgg ggcggctggc  284461 cgggcagagg ggctcctcac ttcccagtag gggcagccgg gcagaggcgc ccctcacctc  284521 ctggacgggg cggctggccg ggtggggggc tgaccccccc acctccctcc cggacggggc  284581 ggctggccgg gcggggggct gacgccccca cctccctccc ggacggggtg gctgccgggc  284641 ggagacgctc ctcagttccc agactgggtg gctgccgggc ggagaggctc ctcatttctc  284701 agacggggcg gctgccgggc ggaggggctc ctcacttctc agacggggca gttgccgggc  284761 agagggtctc ctcacttctc agatggggcg gccgggcaga gatgctcctc acctcccaga  284821 cggggtcgca gccgggcaga ggtgctcctc acatcccaga tgatgggcgg ccgggcagag  284881 gcgctcctca cttcctagat gtgatggtgg ccgggaagag gtgctcctca cttcctaggt  284941 gggatggcgg ccgggcggag acgctcctca ctttccagac tgggcagcca ggcagagggg  285001 ctcctcacat cccagacgat gggcggccag gcagagacgc tcctcacttc ccagacgggg  285061 tggcagccga gcagaggctg caatctcggc actttgggag gccaaggcag gcggctggga  285121 ggtggaggtt gtagcgagcc gagatcacgc cactgcactc cagcctgggc accattgagc  285181 actgagtgaa cgagactccg tctgcaatcc cggcacctcg ggaggctgag gctggcggat  285241 cacttgcggt ttggggctgg agactggcct ggccaacaca gcgaaacccc gtctccacca  285301 aaaccagtca ggcgtgtcgg cgcgagcctg caatcgcagg cactcggcat gctcagtcag  285361 gagaatcagg cagggaggtt gcagtgagcc gagatggcag cagtacagtc cagcttcggc  285421 tcagcatgag agggagaccg tggaaagaga gggagaggga gaccatgggg agagggagag  285481 ggagtaattt tgcgcttata aggtttttcc tttgtaattc gtcatttaca cacactatat  285541 aagagaaagg catcatagag tttagtggat gggatcaccg ttttaggtgc aataaatgaa  285601 gaccaatgag tacatttata atgcagagaa gttcagactc gagtatcatg gtttacaata  285661 ttctagtaaa attagcacaa gatagcaaaa gcaatggacc tcaacttgtc agctgaaatg  285721 ttgaactcag taaatcttgg ccctgtagcc caccttctcc ctataagttt actagcattt  285781 ctagaagcag ggaaagatgg ctaatatcaa ctgcatattc tatttatgcc tttgaattct  285841 actaaactcc tggatactat catatgccag tcactgtgca gtagatgggg tggataaaag  285901 gatttgataa atatggtact tgcttcacaa agttcacagt ctaataagag ctcgaaagag  285961 acacacacaa gaggctgcag aaggttcaag gaaggcctag tttgctgtca tgcatctggc  286021 aagtggtgga gctgaattct ggcaggggcg gcttcttttc ctgaaacaat ggctcaggtc  286081 tctcagaacc acactggtgc tgactccatc accagctttc cttctatggt catcctcagg  286141 tcccccaaca aagtctgagg gcaacagcac actcatcacc ctgtgattag cacattgcct  286201 ggtttccact gtcctccttt gagtcaaact ggtctcagtc atcctggaaa atatgacctg  286261 gggggttggt agtactcatt tgcttaaaat cttccagtgg cttctcaagt acttagaatg  286321 atttccaaat ccctttctag gccttcagta ccctggatga tctgctcctt ttctttctct  286381 ctcaagtcat ttgctacctc ttttgctctt gctttgtaa gttcacatgg gcttcttttt  286441 atgctcaaac atgggctgct ttttatgctc aaacacaaga tggtccttgc atttgtaatt  286501 gctgtttctc ccgcaagggg tgctgttgcc ctagagctag gaatggctgg tttcttcttg  286561 tcattaaaga ctcagctatt atgttacctc cttagtgctc ttctctgacc acctattcta  286621 atgtagccaa tcaggcactg tttatatcaa cacactgttc tgttttcttc ataagatgtg  286681 catctatttg acattactct tgtaaaatgt actcatggtc tatctccctc tgttagaaag  286741 aatactctat gaaaatagag gccctgacct ctcttatttg aactgtgtga gtcacgtagc  286801 aggcagcatg tgttggctgg ctgtttgaat gttgaacctt ctcatttttg caccatcaag  286861 gcagcactgt ctattgccag aactctgcct ccttcgaagc atgtgcccat ggagtctcag  286921 tgtttgtaat gtttttgagt tattgagcca gtaatgcttc tctcctcacc agtgagggaa  286981 tatcctttat agctgatctt ctatctcttt tatctcctgc cctctagtct ctggatgagt  287041 ccaacagtta ggactgtttt caagatttca ggctagatct gtctggctgt ctgactttga  287101 gatggtacct tttataaggt cgtctccatc accctcattg aaagtgcctc ctcggactgg  287161 ccaaaagcag ttaggtaatg ctcttcggtg aacgacagtg aggtaatggc tacagataca  287221 ggatgctctt gtgttgcttt cccattcttt gctatgaggt attcagctgg cttggtttca  287281 tttctatttt ccttacctga ttcagctcct ctgaggcaga cataaaaatt gccatttctt  287341 ccttagacca ttgcttggct tgtacttacc ttttatccct tggctgcctt cttcttaagt  287401 ggcagaaaat ctgagtgcaa atatgaagtc aatattacat gacctggatg cataaaagct  287461 gtaattaaat gactgtaatt tattatttat tgactgctga cagtgttcct gggttagtag  287521 aaagtacagg aaaaaagaca agttcctgtt ttaggtcaca gagaaggaat tttctcccac  287581 gttacctttg gaaggctcaa aaaagctctg tcagaatcaa aacaagtttt aaaacattaa  287641 tgatggatga cgaatctttg atgtagatcc cattgtcatt gacttaccaa atggatagct  287701 tacacgggtg agggcctact aggtgcaagc cattatgaac aaactctgtg ctaggtgata  287761 aaggaataca gggatgtaga agatgtagac ttacgtagag gttgcaaatt tggcctgcag  287821 ggtagattca gctaatggat atttttgttt ggtatgccca gtggtggtgt ttgtttttgt  287881 ttcatttttt atgagctaat attttaaaat gagagctctt acataaaaac acatggattt  287941 attgtttttc ttgaaaggct ggcaacatta aatctgtatt cccactaggg agaaattggc  288001 tggagttgag aaaccactgc catctgcagt tgggatattc attctccagt tcctcatact  288061 cttcaccact cttttctctt acaagctccc gatataaata gagaaatcaa ttgtatggcc  288121 cttgaagaga aagtgtgtgt gtgtttgtgt gtgtgtgtga gagagagaga gacaggcgtg  288181 catcagtaga aatgcagaca cagaggagga gacatttgaa ctaagtcttg aagaatgatc  288241 aggatttcaa gagatgaaag aaagaattcc cggtggaggg acaagtgtaa gacagagcac  288301 cagagataga tagtgtgggc aatccaggca tagattaaaa aaaaaaaaaa aaaaaactaa  288361 aatgaggctg ttttagagca gaaaaggcta ataagaatgt ttctctgcta ttctcctaga  288421 cctgctaatc aataatatgg tttcagaaag tacctgtcat gaagggaagg acaacctgag  288481 ataggcagag gacatacttg agaattctgt cagaaataaa agataaaatc atggtccttt  288541 ctactgtatg catgcatgtg catgtataca cacacacaaa gcacatgatt tttttcttct  288601 gaattccaaa aataatgcca gtttattgta gaaaatttgg aaaatataac aaagctaata  288661 tgaaagtaaa aatcataggt aatctctgcc actaatgaga ttaattattt ggattgttga  288721 atcaaatagt gttagataac aagtgctaca tatttatata tagtaacaga tttttataaa  288781 tatacacata tatacttttg tatacgtata tatgtgtgta aacaggtagt agagtagact  288841 ggttacttgc ttttatttgt tttacctaac actgatcatt tcccaatgct attaactgtt  288901 gttttgtaac gtttttaatt tgctttaagt tgaactgtct aattattctt atgataataa  289021 gtgttgtgat gacatttaat tatatccatg tacataagta tcttcataga taaatcatag  289081 tggatgtaca aattattttc ttatgataaa tttctctgag ttgaattgct cagtcacagt  289141 agagggcttt aaaaaagtct attcactttt attacaacag cctctgtaga gactctgcag  289201 atttcagcat tagattcaga gatctataga atgctaaagt taggtggatt ttgacacaac  289261 cagttgtaat gcatgtattt aacatatgaa aaattgcatc tgtgaattga aatgaggttc  289321 ctaagtttat gtagccagag aataataagg acaatgaagt acacttctgg acgaaaatgt  289381 tatgttaaat gtattgattt ctgtactggc tctatctgag taagcbgggt taaaagggat  289441 tgtgaatatt tttcaagaca caaatttatg gtcataatgt tatcacaaca aacctatgaa  289501 gattaactaa ggtggaaaaa ttactggctt ggagcagatt accagaccaa tgtaagttaa  289561 tgtaatgtaa gttaatgtct ccaaaggctt ctctgagcac agttctcagt gtttcagaag  289621 agttcatgag gagtagaata gtttgtccct aggaaggatt ttaactgctc taatttaata  289681 caaagtgtgc cctcttgtaa actttgggtt ttctttggca gttcaatgca gaatatcttt  289741 atcttcactt cagttttcat tgacaccatt cttactattt accagcaaag caagtaaaga  289801 atattcaaga agaaatagaa ttagattcag ggcatgatgg ggtaagggaa tgttcaataa  289861 actcagcatg gtgttcacag ttgtattttt aaggtgatca ttgctcactc gtaagtgaga  289921 gccgaacagc gatgggagac ttctttaaag tctgatgaag gatgctcagg attatccata  289981 aataagaggc atataattga ctgactacct tagtggattc ccaatcatat tatattgtat  290041 tatgtcacat ctcaatgtac tgcttatttt gtatcagaaa ctctacaaaa tactttacat  290101 gtattattcc atgtgatcgt accagcaatg ctgtgaggtg gtattattgt tcctacttta  290161 cagtaaactg aggcttagag gatgttaaat aattgctcaa agacacatta atggttagtg  290221 gtagagttag gcctgaaact cgagtctcat caccttcaaa gccatcaacc aaatttccat  290281 catgttgaat ttacaccgta atgcttgact ctagaaattt taaaaattct gccaaaactt  290341 gaataattca tacactaaac ctatggcttt tggaactcaa agtgctcata ggcttaggca  290401 ggctacctgt ggtagaatgg agttagcaaa tgaactggga tacagaatta gaagatcaac  290461 tgttctctag ctgggaacgt ggagatatta tatatcagtt cgggaaggta gaatgataaa  290521 gaatcaggaa gaaatcatca gcatcccata aggggttgag aacatgggaa cagggacaat  290581 gcagactgta ttttaagtgt tccttgaata tgtggacagg atctgtctgc agttaacagg  290641 atcctattct caactagggt tgaagtacaa agcctcaagt gctcaatcat cctagcagac  290701 gaggctagag tttgtcctag atcagtgctt ctggaatttg agcatacatc agaatcccct  290761 gaggacctgt gaaaacagca tttctgattc agtagatctg aggccaggcc cgagaatgtg  290821 cttttctgac aagttcccag gtgatgctgc tgactctcgt ctgaggacca cactcaaaag  290881 ccactgctct ggagccacag cccagactag cttgcagctc taagcagagt gattccagct  290941 gtgagaaatg ggatttatgt gcagaaggtc aggcaactca ttccacaaca gaattaattc  291001 tctctgagat cctgaattgc atttcatatt atccacaggt tggcaatctg cctcaaataa  291061 tgaaacttgc agagagagaa gagatcttcc caggcttttt ctttgtcaag tgagcaccat  291121 atgtcttccc tctgggtgga tgactgactt agcacatcac aagcaaaggt ccaaaaatta  291181 aacaacatca tttccaatcc ctcaactatg atggacttta gcccaaatcc acatgggctt  291241 ttctgatgct ggcccccaac agtcttacca ggaatgagca gtcattagtg agtttattac  291301 acttagctca ttcaaataat tttatgatct caaagttcaa gagaatctgt ttttttttct  291361 ttttccctaa ccgtttttta cctttgagct ttttctattt tagagacaaa caaaatatat  291421 tgcaaattga tttatattta ttaaagtatt gctttaaaaa tttaaaatat aatataacct  291481 aatgtttata aaagcctacc tctaaaacaa tgagcactga cttttatact acatatgtgt  291541 agtttttctg ccttctcttt tgttttagtt ttaaagtgag agcttctgtg tttattgcat  291601 aagttaaatt ccatttctaa ggtgtttaca gagaagcaat tctttcataa ctggttctaa  291661 ttttcaacca ataacgtatt tttagactag aaagggatct tagaaatgaa ctagttcaga  291721 ggttggcaaa cttttgctgt aaagggctag atagtaagta ttttagcttt tgcaagccat  291781 ggtgtctcta ttataactgc taaatgctgt tgttttagta ccagtcatag ataatatata  291841 aatgaatgaa tatagctgta ttccaataaa atttatttgt taaaacaggt ggcagtccag  291901 atttggcaca tgggccatag tatgctgacc tttggtctag ttcatttttg atttatgtgt  291961 caggaaacta agcctaatga gataagtgac ctgcccagct tacctagcta agaaatggta  292021 gagtgaagtc taaaatgcag gtttgaatcc cagtcaaatg tctgttctac aaatccactt  292081 ggtccagtat ggccaccctg tatcctttct gtgcatcagg ccaatttata gatcaagggg  292141 gttgttcctc cagcbgtccc tgctgcaaac acagcaggaa gctagggacc ctagggtgtc  292201 ctttatgctt ttctagtcaa ctagttataa aatgtctcat ctctaatgac cctcaggagc  292261 tctatgtgct tgtgagagag tgaagaaaac aggcatttaa aacgttgagt tttctccacg  292321 ttcagtagtt tggtgggcca cctcatgata ccattctaag gaggcgaagg cttaagattt  292381 gatttttaaa cagagacaga gaaaggctgt tccaaggcaa cagatgggta cgggccaacc  292441 gagtaagcat ttttcagatg tgttctgtga tcacacaggg ctccagggga aaagtgctga  292501 agatcatcca gagcagggca ctcccccaga aggaaaaaga ctcagagtta atgttctcca  292561 gataagaagc agttcatttt tctccatgaa ggacacattt tttttccatt gatgatttca  292621 gcacaaaaac tgtcaaccaa acctttttgc ctcttgtgaa cattgccctt ctagaaagtc  292681 ggcaaactaa cgaaacactt tgtagctgtc cttcaacagt atctagagtg atactgcagt  292741 tatccaggtc atctttgttc tgtttaatac acaggactct ttattatttc attatgtatc  292801 atcctatcat tttaccttga gggttaacca ttcctgttat gccatacttg ctcttctttc  292861 cctgaatctg ttacaaggga gattgtccct atgtttcagt tgaataggag agtaatactg  292921 ccttttagga aagtgatgaa gttgaggcct ggattcatga gactcttgag gccaagcatt  292981 tgaaaattga gaatggtttt gttggagttc caaatcagga accaattcta tctttttaca  293041 aatatatttt tgagttcttg ggtttgggag gaacagaggc tctcttggat catctttgtg  293101 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgg ggagggagct  293161 gttatgggga tatgtgtggt ctgaagcaca cctggagata ataagatctg agcagtgcta  293221 ggaacctgcc aatgtcttgg tgtctttttc gtggtcttct tggccctctc atttcgtatt  293281 tactgcattc ttattccctt attaccagtt ggtcagtctc ctctgattct ctatcccaaa  293341 ttaaataaga gccagtttta ttgcccttgc taattagcat ttactccatt gttagaatct  293401 cctgttagga tgcctaatgc atcaccagga agcctttaga tgggccaccc tatcacagtt  293461 aaccacttcc attctattgg ttttttgtgg ctcctctgta caaaaaacag cctagtgttg  293521 ctgccctgag catgaaggtt aatatccaag acatggagac tggacattga attgagtaac  293581 ttcttaagct ttttttatat ttcttttgct gtatttactt tatgttaaag ttaattcaca  293641 ttttcattga aaaaattttt aatatgcaaa acttgaaaaa gaaaaggaaa actatagttc  293701 atcacccgca tataaagtat gactatcttg ctgattattt tccagtcttt gtgcatagtt  293761 tcatatagtt gattaatgtg tggctttata ttttttgttt aacattagag cacagttttc  293821 ctcatgtaca taaatattct ttcaaaatga ttgtaattca ttgcaatata tcatagtata  293881 aatatactgt atatacataa ctaatgttca acacttagat ggtttcatca ttgcttgtta  293941 aagtttatca tcacatcaga taattttatt aagacagatt ctagaagttt tcttacagaa  294001 tcaaaaagaa taagattttt aaagctttta atatgtactg tcaaattgtt tttctgaaag  294061 gttgctacag tttttactgt caccagcagt gtataaggga gcctgtcttg ctgtactttc  294121 atagcattgg atgacagcat ttaaaaatga gtctcactgt gtttaaaaaa aaaaaggtgc  294181 tttctttgtt ttatttatat ctggttactt atcctagtga ttattctgct attgttgctg  294241 aagggaagta attgaaaccc tagccatgcc tatgcagaac aatttgcctt tcagttttga  294301 ccatgtgaga cgctaatcca atgaacattg tgtctcctct agccttcata caccgaattc  294361 gacatcagtg gcaacgtcct cgctctgatc ttcaaccaag gcatgatctg gtaggccagc  294421 tgttggacag cttatcactt acagaaaagc ctcccaggtt atttttgcat acagcattga  294481 atcctggtgt tagaggagaa tacaatcggt gtctaactcc atatttactt ttgcaaagtg  294541 gatgcctgta tatagtttcc ttttctttca tatcttaaat gtcagtcatc aaaggtgtct  294601 ctctgttttg caaagcactt cttcatcaaa taatgggagt ctgtgttctg gttagcagat  294661 ttatttgagg actatatttt tatattttgt gacgccagga tctaatatta aaacattaat  294721 aattacatta ccacatgata agtatgaaat aaattaacat aaggcctttc cgagagaccg  294781 agtttatttt gttgtcacta ctaaatatat ttaaaatgta acttatagct acttttaaaa  294841 ataatacctt atcaaatcca atagtttatc gagatgaaac gcatgtttta ggaaggtcga  294901 gttaaaatat gatcttcatt ttgtaacttg ttttataggg ccatggcaca tcagaattat  294961 tttttttgat gtgtgaaggg ttgtcatatc ttttatcaaa ttagagcatt ctcactgtaa  295021 acttgacagg ttaagatgag tcgatacagt agaaatcgtt tttgagttta aaaactgaat  295081 cacgacatcc gattcatctg gggaccatgt gtcttggaaa tctgtcactt cagatttcca  295141 gcctacaagc agttacaata aggctacttt atcctgggga catgtgccta agacaatatt  295201 atgctgccaa ccataccatt gtcctattca caagtgccgg tatagactca gtttttgaac  295261 aagtttcata tattgtacca atagatctgt cctgaattat taaacctttg ggtgctgaca  295321 gacaccggac ccctctgcaa atgctaaaac cgtcttgctt ctgtcacaca aagacaactc  295381 tccagggctc catcgtcctg ccatgggatg actgttaaat tcctgtgcct gactaggtga  295441 atcaatatgg aaaagatatt ataaaaatat tgtttcctcc tttgtcaggt aggtttaaaa  295501 atctaatttt tattcccttc ctttctaaat tttccaagta tgactcacat gtccagactc  295561 actaaggaag gaaatgcatc ctacattttc caagcaggga ggaaagtcaa ggtggcccga  295621 ggaacgtcta ctgacacaga agtaaaggga gcagcttctg tgggttctga gctttcattt  295681 cctggagttc aatttgctgt tatggcagaa aatggctaac acggctatgg gagtaatgag  295741 aaaccactgt tctatcagtg gcttttacac aaagtgtcat aaatccttca ggcctcatgg  295801 gtaccattca cgcagacata tgctgcacgt cgattgtgtt ctttcagagt taagacaaca  295861 gattggtcta gaaatttgtt tttattgtca gaaaagctgt tataatggct gtcctgcttg  295921 gtttcactac tgattttgca actatgttag tccactattg ttcatattga aattcttaaa  295981 tatctaacat gtttttccag ttctctcgtg ggcagatcca ttatcaaaat ctctgcactg  296041 tctttttctg tttattaatt cttcagacag tggtcaagct tgcttctggc taatttgaag  296101 agaatattga gttttttgag catacaaaga tattcacaca ctttccaaag ttccagaagc  296161 aaactgacca ttattctatt attcaccttc acgtcaatgc ttggcacaaa tattcttttc  296221 ctaaccctag gaggctgatg agggaggggg atgtcatgta gagggaggtg tggggcaggt  296281 gtaatgtaaa attagtaggc tgactctgca caaaggtcct cacacacaat cgttccatta  296341 ttttatgaag catgaggata taatgcctga gcttaaccat tttctacaga aacaattaaa  296401 aatgtacggg gatgttttat tcaattccat tggcttgtga ctggagatat tgaattactc  296461 ctttaggaat cgctgagtag tggaggttat ttacgcagat gttgttaaca tcaacattta  296521 tagataaaat ccattttgct atgatttggt tgaatgatta gtaaccttta tttacgcact  296581 tattttttga aatacacatg atagtttctg tgctaatatt tttaaatgat gaaagcacag  296641 aatatcttta tcatagcagg atattgagaa atggcagaga acacacagtg agagagaaaa  296701 tgagttttgg acattgctcc aacactgctt cactgggtac tctcccgcca ggtttatcac  296761 ctttttttct tcactttctc agttgatcag atgtgaataa tttacctgac atgtacatgt  296821 cgctgatgta ataaggagag ttaaataaaa gaagctttca ttttctttga tcttccagga  296881 agaaaagaat tttataaggc taaagtgtta caatgatttt tactgacaga tgatgggatc  296941 atgcctgggt aagggactta gtgagccgag ctgattagta atgcatgagt aaagatagga  297001 tgagcattaa cattcggata ttattatgcc aggacttatt tttctagctt atggctcttg  297061 agttatttgt ttaaaatgtc tttgtgatac ttattttgaa attttgaaat ttatttatag  297121 atgtatacac aaataataag catatacata caaacaatgt gcacgtatat aggtacaaat  297181 atatgtggtt ttaggcaagt ctcgattttg aattacgtgc aaaattatat tttagaattg  297241 atcaggttat gcagcaatga aacaacctca aaatcgtagc agctcataaa aggaacatgt  297301 tcaatgtggg gtggaagaag agctttgctc ttagaactta ccttcacttt agagacccag  297361 actgatggaa taggatccat ctgaaacatt gctatcacac tagcagagaa tgaagagaag  297421 gaaaaccaca caggactttt aaagtttcta cccagcagta aggacctaat ttctattcat  297481 actttattgg ccaaaacaag tgatgtcacc acctgatttt taggaagact caaagtgtat  297541 tacatcaaca tgtattggta ttggggagta taatctagtg ctttgcaatt ctaacccatt  297601 agctgggact atcacttgct tacttgctca cttttttggc gttccctctc tcttgctgtc  297661 ctgtaacaaa agtatactgt attgttttaa aatctgtctt ctcattagaa aaaaatagtt  297721 taacttccta caaagtcttt gttcaattca ttatggtaaa atatcattcg tatctattgt  297781 ccgaaatctt gtcaacaaga cagcccaaat tgtgacaata ttccactttt caaataaatg  297841 agttaacttt gggttggcaa aagttcaatt atagtggaaa ctaatttctt catctaaatt  297901 aaaaatgtct ctataatgaa ccaaatttac gttggattgg ctaaacaact attcagggag  297961 tacaaaatgc taaacctagc tataaatgtt gagggcttca ttatagatag gacagtttaa  298021 aagacagggc tccccttaca tttttaaaat aagtgcacat atatcttctt tttgattttg  298081 aaataataaa ttgctattta tattgattta tggtgctaat gaattttctc atccaagaag  298141 agtgaaactt attttgttga aataatcaac taagccatca agtaaaagtg accacaccta  298201 agttgttccc acctaaaagt agtattttaa aatgcttata aaaactcaga tgcacaaagc  298261 agagaattcc caagacaagc taaagtaaga aagtaaacag ataaactaaa tttaaataaa  298321 tgtgtggaat tttcatctca aaaacctata agctagttat aaattttcaa taaaacccta  298381 ttttaggagg cacaaacaca tcattgcaat tggctttaaa acaccatatc acctacaaag  298441 agaaaatgat caacatcaga aagagaaaat ttattttaat ttttttcttt cattaagcaa  298501 aaaacttttt tcatttgtac agtcgtggcc cactgcaacc ttgacctcct gtcattaagc  298561 aaaaactaat tattcatgac agaagtgatt aatgcaaatg tacagttttt ttgagtagaa  298621 gaagtgactt taagggttaa ttatttttaa caagttatat ttataggtgt attagtcaat  298681 gatataagtg ttggggaaag tttattttag aattagaaga aagaagtaaa acaattgtaa  298741 atattgttta ctctgttgta gtttaaattc actaatgata gtaggtatag ttagttacag  298801 catcctttct atgaaataat tatgatatgc aattcctaca ataatgggga aagtggcaaa  298861 atgtgtttag aagttggaaa tagataagtg cagtttcttt atgaaaaggg tttgtctggt  298921 tgaaagtggc agtgtatttt ctgcctttgg aaaagaagca tgatgtcaaa taaacaggtg  298981 cagtgtgact ttgttatgga gtaaagactc aaaactgagc agagttctgt tttctttcta  299041 ggatgggctc cttctttgct cccagcctcc caggcatcaa tatccttcga ctccatacat  299101 ccatgtactt ccagtgctgg gccgttatgt gctgcaatgt tcctgaggcc agggtcttca  299161 aagcttccag atcaaataac ttctacctgg gcatgctact gctcatcctc ttcctgtcca  299221 caatgcctgt cttgtacatg atcgtgtccc tcccaccatc ttttgattgt ggtccattca  299281 ggtctcttgc ttttgaaatt tgactcaggc atcgtgttct ttcgggggtg gaggtgggaa  299341 tggtcattca ttgtataagc tattttttcc ccccaaacaa tgacattttt ggttggtgga  299401 aatgagatcc cggctgggcg cagtggctca tgcctgtaat cccagcactt tgggaggctg  299461 aggcaggcag attacctgag gtcaggagtt cgagacaagc ctggccaaca cggtgaaacc  299521 tcgtctctac taaaaataca aagaaaaaaa aattagtcgc gtgtggtggt gggtgcctgt  299581 aatccctgct acttgagagg ctgaggcagg agaatcactt gagctcagga ggcggaggtt  299641 gcagtgagct gagatggtgc cattgcactc cagcctggag gacaagagca aaactctgtc  299701 tcaaaaaaaa aaaaaaagaa agaaatgaga tcctttgggt attcaggttc aataggtgac  299761 atggagattc ttaggcaagt tctgtctatt tcctcatttg ggaatcataa aagagaaaat  299821 actttatact tttccaggct ctgcctgggt aaaatatgta tggtgaatct gagctgtttc  299881 catgttagag gatagctaag agcaaggtct gatgacagtg gtctggatgt gagtttgcct  299941 gactcbgggc cgtcacatcc agacgtggtc agctatcact acttctcttg tgcattacta  300001 ccttaaaaag agagagagag agacagacag agagagagag aataccccac actttaccta  300061 ggaaagagaa ttattactaa atactaatga gcataaggag ggccacccaa tttgttatcc  300121 aaaatatcac atgctagtga aaaaaattaa ggcbgttcca catatatatt ctctcctaat  300181 tatcattcaa gtcaggaatc gagagtcaca acggctcctt gatccaattt agagatacac  300241 atttctacag ttctctatga cagagctctc ttctctctat gacacatatc agaaacctaa  300301 gtccctggga tctggaggat gaagtttctt tccctaaagg gccttagaaa tgaatctact  300361 acaagttctc ccaagaatct ctgcatgttg attcactggc cagcatgcac ttgagctgtt  300421 tctccttttc agtgaaggaa atgagactgt aaaaagccat gtgaatgata tgcatgatgc  300481 tgtaatgccc acatataatt cctccattat gttgtcagac ccaagttatt taattaaagt  300541 caaaaggttc attgctgaca gactaagtat ataagagaca ttttcactct taacagtagt  300601 ctgagttatt gctttgctgg aaaacaagaa aatgttaagc cagctgatcg agttaaacta  300661 gctggacctc tgtctactca gagaactgat gttgagaagc tctgttaatt ccgttgtgtg  300721 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttccaagtg ggctgaaata  300781 aataatgcag acagtgacat ctggagacta aatatgaaat tacagtcttg atgagacatt  300841 cgtctcaata aattccgaac caatctcaga gtacaaagtt caaggaatat gccattcaaa  300901 ggctttagtt aattgcaaat tattcacact acttattatc caggataagt ttaggtgtgc  300961 attaagctat taattggaag ttgatccttc tcagtaaaac atagcaaagg accctagctg  301021 cctgtaaggg aaaccacaca atgtaaacat ggatctccac agatgcattc agatttacaa  301081 tacgtcttag acatgaacaa tagttgcaca atttcagctt cttaagccct aactcttctg  301141 gctttcctaa ttggcaaact taggcaaaat tatggcatgt aaatcactat tttgaaatca  301201 gggaaattta ttttttattt ttaaaattat ttatttgttt tttaatttcc ataggttatt  301261 ggggaacaag tagtgtttgg ttacttgagt cagttcttta gggtgatttg tgagaaatca  301321 gggaatttta aatattttca atggagtact gggaagggtt atctctatgc tatttagatt  301381 ttttttttca tgtcagtttc ctcactttag agccaaagga tgtttgcatt gtttatttgt  301441 ctggacttaa aagtttgaaa ggattgtcct gctctagaaa tgaggtgaga atgcttgtat  301501 gcttgtacta gtgggtgcct catagcttgt catctttatg aaccccaagt tttaggtgat  301561 ttgcttaacc ttcctggtga aggttgtctg actctatcta gatcctgggc aagcaggaat  301621 ttaggaaata taaatttgaa ctaggttact ggaggtatca cagtgatggc tagttgctct  301681 ccagtgtagg gaagttttca ggtaagatgg ctatagtata tttatccatt cagtaaagca  301741 atttgatgag atattctagc ttgtctggtt ttataagacc tggctagaga gggtaaattt  301801 tccaagaaat tattccaata ggctagtaag tggatttatc gtaaatagtt gacaatttaa  301861 agatgtccag atgaaggcaa ttctaattgt tctatagcat ttcctgacac ctgatgtttc  301921 ctcccatcta tgtcaataat tctgaacaat ttatagttct ctaggttttt atatacatcc  301981 ctgcttacat tatgacaatt ttatttttca tatattttca tcttactgca aagataatat  302041 gtgtttatgc tagaaaacct aaacattgta gaaatatttt tacatgaaaa gaaacatggc  302101 ccataatctt gaaaacctga aataacaact ttttagcatt ttatattctg ttttgccttt  302161 catgcatgat ttttcataac tgagcttgta ctgacacagg atgtttctca gcctcttcac  302221 tggactcaca gaggggcacc ctgtctactc ggcctgctgt gcttaacccc ttgtgggagg  302281 aagcacgtgg gcaagtgagt gcgggatctg gcgagacaca ctgggcactg acacaggagc  302341 aagctccatg tggggcccgt ggccagacca ggtgtgtcac cttgaggaga atgcaatggt  302401 gcccaagtgc ctatgaccct aaagccccag agggggtgtt acaatgcttc ctgagttcca  302461 ccatcctcag cctgatggat ggcagtgtct tagcagctca gttggcccct tgcctcatca  302521 tgtggggcag ctgccctcca ctggagaggg caaagggcca gtgtgacagt ctttcctggg  302581 ttcccacaat cggtgggtcc caagctcttg tccagcatcc aagaagaatg aggtcacatg  302641 gattattgaa ggatggtgaa ggaggagaat tttattgagt aatgaaattg gctctcagca  302701 gagagggcag ttggagaggg gccaggaagg gcaggtcatc ttccccaaag tcaggttgtc  302761 tcttctccaa agtcaggccg actcttcccc aaagtcaggc cgtctctccc ctctaccaac  302821 tgagtctgtg gtctttatag gcacaggatg gaagtgtgtg ctgactggtt tgtgagtatg  302881 caaaaaaggc taaagtgaag gtgtcactca aaggtagaca cgacagtata gaaacccaac  302941 taggaaaggg taggtatatg taaaataggt gaagggtggg gatgaatcag aggaaagtgc  303001 gccaaacagg aagacaagtt ctcaatccgg tctgaggatt taacttggac cttggctttc  303061 aggctttaaa ctgtctttgg cttggaggtg gcatttcacc aggtacctgc ccctatctgc  303121 ctaggcattt ggctgcctcc tgttgctatc agtatactag gtgcaggttt tttagtatta  303181 aaagttaaaa ttatattgtg agactgctat tatattggtc atttgcaatc atgctttatg  303241 catctatttt tcttaatagt ttagctgact tctagagatt ggggatagag aagtttcctc  303301 tctgtggatc taggacacag taaagtgctg gtcaataatt tgaatgaatg aatgaataat  303361 gactgcttat tgtgcactaa gcactagaag agacacaggg ttaagtccat gcattaagca  303421 ttgattctgg tcctgtggca cttatcaccc agcbgggaag acaggcctcc tcataaactg  303481 ttctaatcta gagtggcgct atgcctacag caggactatg gatagacaca gacaactgga  303541 aaacaattct gagaatattg tatgatagca tactttggct aacctggcag gagaaggcat  303601 tgccagggac atgtagatgc gtccataatt tgtacgtaat taagatatct ggactccttt  303661 ctttggtaaa agacctgacc tgaaaaaggt acacaggaat ccccagggac ttagcaactt  303721 tgctttgggt cacactggat gctgagaagg cctttgtgtg tagggataat ttcataaaat  303781 ttgaatgccc ccactctaac tacgttcatc agctatgacc tgaggtgctg gagaagggag  303841 gatagatggt cttatctttt ttggtacttt taatttatct gcttatcctg tattccatct  303901 ggcbggggct gcattggggg gtatgaacaa tttggaatgg tgaaaaataa aacatattgg  303961 aatagggagt tataatctta tattgcttgt aagcttcatt ccctcttatg tatcataagt  304021 cttgaaaatt agagtgtaga tctttaattt gtgaagcaaa acttgtacct ctgtagtcca  304081 atgactactg acaaaatata tggagtcact atgtctgctg gaagatagta ttggttagac  304141 caggagaaaa aaaccataat ctgggacttg cgtgtcattg ttatttagta gttgaaaatg  304201 cttaaagatt aaaatacaaa agcaaaacta aacattgtat taaatgttgc accaacattt  304261 attctgatga tgcatacaat ttggtgaaac ccaacccaaa tctcttctga aaattacatc  304321 ttttcgtagt acaatcagta tgcatataca gagaaaataa tgatgtaatg aatattttga  304381 atattatggt acaattctag ctattcctta gtaagtcaag acatcctgtt ctcagttttc  304441 tagtttatag gagctgatac ttgccttcat ggagcttagc agtggagcta agctggtatt  304501 cattagggcc tgtccaggag aagaaactga gagggaaaaa acccatgatt cggtgtggtt  304561 accttaccta ttaacatatc tgatgaagga agtctggtgg aaaatgaggt ggaagctatt  304621 gcgtggaaag agatattgga ttatatgtgg attttattcc actgggctat tccttgctct  304681 catttccaag gctaattaaa aatacttagc tcaaagagag tgttctccta caagagcagc  304741 tgactgagag gcagacttat gagctattta caaaatatat ttcaatcaaa atcttagaaa  304801 tacagttttt aaaaatcttc tcctaaatat gtggttaatt ttctaactgc tttgactata  304861 tgtttatact gggatcatat ttctcgtatc ttacccatat attgactaca tgaggtcaaa  304921 gtgtcagcaa gttgtagcta aacatcagat tcctaccctg aaagaggacc taagcagtaa  304981 ttgagaaaga tttccagttt tcttgcttta accatggttt ttccatatgt tcttaataaa  305041 cttatctccc cctttttaat tcccccagtg gcaaaaatag aatgtttgaa gtcattggag  305101 agaccctgga gcacgatttc ccaagctgga tggcgaagat cttgagacag ctttcaaacc  305161 ctgggctggt cattgcbgtc attttggtga tggtgtatgt gcttttcctc ctcatagaaa  305221 gagcctctgt gatgttcttc ctggctgttt ttacatttca gctttttcag ctctctcact  305281 ctccctaagg gttctgctgt aacctatcca aattcaacac tgattacatg gtggtgagag  305341 gctaaaattc atgagccata ttctgatcct attggatgta attcacaggc atctgcatct  305401 gtctttgctt ccccaggatt ataagatttg ttcccaagta accacaataa ttatccataa  305461 acagctaaag caagggaaac ataaatgcta aatgctaaat ctaatcagta cattgagctt  305521 ccccccaaca acccggcctc cacctctcgt tccataaagc agatggcaat gaatatacag  305581 aaataatgat cctctaagtt aatattcccc ttgggggccc tatagactat attttagggg  305641 caagggcttc aagggtctta aaaatttcac tgtccttgtt gttagagggc cgccaataac  305701 tgtgtgttca cgataataga atcagaggac cagaggatct tgggaagttc ctgtagtctg  305761 tcccttcaaa gtcagaagtg atttccaaag gggaacttgt cagatgactt ttgttttcac  305821 ataactttca ttggcttctg actcttggcc atcacagata aacttagatt ctaagtaaaa  305881 gtacagattt gcbgtggaag agccaaaagc agcgtccatc tcttcctttc agtccctgag  305941 tgcctcctac atagaatgtc tggagctgcc acgactctca gtcagtgggt aaatattaaa  306001 cagccccagg gacactttaa gaacaaagtt gatgcaaagg atttggttca tttaaataaa  306061 ggtaaaacaa ggaaatctca gggagaaaac tcccagtggt ttgcagtaaa tgagcaggga  306121 ttgtgaccca gttattgtcg tgatcacaag ccacataaag tagtgagggc aggtttatct  306181 tcttcaattt tataacctaa gaaattgatt tacacaaaga aagtgatttt ccctagacaa  306241 gagagagagt aaaatggtca tagaaggacc tgaagcagat cctttcacag taaatccagt  306301 gctcacttct ttatactgcg aggctttctg tgagggagag ctaataacct gtagggataa  306361 ttaaacagta aatcagatta ccattatata ttacataacc ttgataatgg ggtgctatta  306421 agaatctgat agtaaatctc tggcacagat gcattagaaa atgacctact gaatgcagca  306481 tgtttcacca gatggccttt gaaacaattt tctttctcta catgtccatg atacagtggc  306541 ttctgagagc atgttaatca gtatcctgtg gcctttgaga gtcaaggccc tttagtggta  306601 tgaatgaggt gttgtttaaa acacacacac acacacacac acaatgtaaa tgtcagattt  306661 cgttaccata ttcttacttg attaggagac atgtttattt ttaagtgaag gagtggcatt  306721 gttcaaatgc cttaatccaa agatttagta atcagtccta agagggttta aaaggaattc  306781 acactgcctt tgtttcaggt actatttaca cactgactca tttaattccc ataacagctt  306841 tgagaagctg gcttcattaa tcatactatc aataacacat tgaaattctg ccccaagtca  306901 agtgactaag tggaactgaa actcatgtct tctccttatt tcctacactc acttgcagca  306961 ccaaacaggg atcagaatca gtgggaattt cagatgggct gaaagccact tgtccgaggt  307021 ggtatagacc cagggtcagc acacttttcc taattcgagg gccagaggca aattaggcca  307081 agaggcaaaa ttgaggctct taattaagta attactaata ataaccgttt aaaagacaga  307141 aaaaccattc ttaattcatg ggccatacaa aacagtctgg cagtcatctt catcctgcag  307201 gacctagttt gctttgatct ggacagcctg gaggaaagct ggccccatgc aaatgtcaaa  307261 tagatgtact gaaaggttga ttgtggctct gaggttctga tttaaaaccc agattttagc  307321 ttattactga gtatattttt tcaaattctg agatctcatc ttctattttt ggggcccata  307381 caattggctt agctttttat tacctttaat tagagaattg tactagtatg ttgaatttcc  307441 cccaatggat tatattaaat caacctggat ggctttcggg tatctaagca gagttcaggt  307501 tagttctctg caggcagttt cattcctttg gagactagaa aaagatttgt gaggaatact  307561 tatttaacgt gcattacaag gtagaaaatc atggtggata aatagagaat tccagaactt  307621 gaaaggactt gtgaaatctt tgagttcatc ttccaaatcc aggaactttt ctaagaaaat  307681 ccttataata cacaccacac acaaacacac acacacacaa acatttattg agcacctatt  307741 tcatgccaga tattgccctg catgcattta tgtatgtaat tttagtaaaa ctcccatcac  307801 tcatgtaaga gataaacaaa ctcagccaaa ccgtatcaat aattgtgttg ctagcaccag  307861 atggttcata aaggatactg tctttcattt tggggagtag aggaaatgtg ttcaatatcc  307921 agttatttgc agcaaagagt aatataagtt acctttttta ctgcatttct tctttgtttg  307981 tttgttcgtt ttgccttaag tgaagataag catatttatt tttacagaat tgtctggcta  308041 gaatttgccc tttctagaat gtaaatgtca tttaaaatcc aataatattc ctttatacaa  308101 cgttttcttt ttgagggaga aagaaatgca aacaatacat tctacggaaa aaattccatg  308161 ttcattatct atgcctatga ggattacatt cttagctgca aaggccaaag gacgaaattt  308221 aaggcagaaa gtcgttttcc tttttgttcg gcatgttccc taagctgcag taggttttcc  308281 attctctggg atgccattgc catccattta aaatgctact ttcaattata atttaaactt  308341 atgtgaatac atttccagga aaaagctaat attaggcagt gtgaaatagc agacagaaca  308401 ggctgtggat caggagcctt gggccccaac tttccaactt caccccagct tcatccctat  308461 gtcatcctga atgtatctct ttacctctct ggacctcagc ttttatctat aagacaagag  308521 atttagagta gaagatagct taatgttcat tcccatgctg atatttcata atttacttaa  308581 tgtaaattta agaagtatct tggggaactg aaatatacct tacactgtat tttttttctt  308641 tttaatttag tttggccatc tattatctca atgctactgc caagggccag aaggcagcga  308701 atctggatct caaaaagaag atgaaaatgg tatgatacaa tttatttcat agaaatatta  308761 tctttattaa tgtcaagcag tagaaaacac tgagaaatct acttttttcc ccttattttt  308821 tattgtgtag caagctttgg agaacaaaat gcgaaacaag aaaatggcag ctgcacgagc  308881 aggttggaga tacgtttatg tttgtaatgt ttgtaatttt tctttttctt tttctttctt  308941 tttttttttt ttttgctttt tctccattgg atggtgagtg gcattattgc tgtgagcgag  309001 tcattccaca atccttacct tccacctttt tagcccttct caggcatcac atccagggta  309061 tttggttgtt ttctagtggg aggaaaaaaa gagaaatgaa aatgtgggca tataaacttg  309121 gcagtagtga tttttaaaag tgaccttgaa aatgcgcaga aaatgaagaa atcccccata  309181 tagtcgtcta caaacagcag atacaaatgc agatgctctc ctgcccatgt tgactatttt  309241 catacatgga aggatatggc aagaagatcc caagagggtc ctctgggctt tccaccactg  309301 attgccagaa gccctttcta atccattaaa ctttcttttt ttaaaaacct ctttattttt  309361 taaagtatta gagtaaagcc aacttctagt tgccaaaatt aataatatgc tttgagttcc  309421 ccacggaaag gtgataccta agacctttag tgaaaatctt ttccaacttt gtccttactc  309481 ctaactttaa aactctttac attagtagga ctgtttcccc actgtaagta ataaaacact  309541 caaattggtt taattgagaa agagtaattt attcgaccac acaaatgcag ggaaatggta  309601 tgtatggctt caggccactt tcttttttct atatatatat atatttttta attatacttt  309661 aagttctagg gtacatgtgc acaacgtgca ggttagttac atatgtatac atgtgccatg  309721 ttggtgtgct gcacccatta actcatcatt tacattaggt atatgtccta atgctagccc  309781 tccctgctcc ccccaccgca cgacaggccc cggtatgtga tgttcccctt cctgtgtcca  309841 agtgttctca ttgttcaatt tccacctatg agtaagaaca tgcggtgttt ggttttttgt  309901 ccttgcgata gtttgctgag aatgatggtt tccagcttca tctatgtccc tacaaaggac  309961 atgaactcat cattttttat ggctgcatag tattccatgg tgtatatgtg ccacattttc  310021 ttaatccagt ctatcattgt tggacatttg ggttggttcc aagtctttgc tattgtgaat  310081 agtgccgcaa taaacatacg tgtgcatgtg tctttatagc agcatgattt ataatccttt  310141 gggtatatac ccaaaggatt ttttttcttt tttgagacct ggtctggctc tgtggcccag  310201 gctggagggc agtggtatga tctcggctca ctgcagctcc aacttcccag gctgaagtga  310261 tccttcctcc tcagcctcct gagtagtggg gacagcgcac accaccatgc ctggataatt  310321 tttaattttt tttttgaagt gaggtcttgc taagttgccc aggctgctct caaagtcttg  310381 ggctcaggtg atcttctctt tttggcctcc caaagtgttg ggattaaaag catgaaccac  310441 tgtgcccagc attcagggca ctttttatcc taagtttaga acagagtcag gtctgagccc  310501 acctctctgt gaatctctga agctaaactc ctttcacatt ggctgacctt tatggcagca  310561 ggaatggatg cagcaacttc caatgccatg tccttagact gtaaaacttc tttcctagaa  310621 attcctcaac ctctcctcct ttcagattgg ccccatatgg gtcatgtatc catccttgtg  310681 ccagtcactg tgtctgagta tggtaagtta ctgaagtcag tcaggaccca tccttgaagc  310741 tgggattggt ctgttttcct gacacatgtg aaatgcactg gggaggtcac acctacctaa  310801 gagaaggaga aaaggatgct gggtgtcccc aaacaacaaa tgttcaagac ttggttttgt  310861 tgccttcttt atgcttagcc ttttttcttt tccctctctc tatctagcat gcataaatgt  310921 aaagttgaat gcbgggtgct gaattagatg attacagtga tgtacagtta tcagactagt  310981 ttttaatgaa atttttaatt ttttaaatca atactacatg tgtgcataat ttagagttcc  311041 atttagaatt tcataattct ataaggctta tcatgaaaaa cagcatcttc ttctgcctcc  311101 tacaccagtt ttgctctctt ctcctcccct gcactcaaat accctaagac aaacactttc  311161 aatttgttag ttgattttta gatatttatc tccaaattac ctaattttgt tgtaatttct  311221 tgacttttta gttttaagta ttatctctta aaattattaa ctacaatgga tataataatt  311281 ttaatagata atatttaaac gatttttata ctcttgcccc agtctttcta tgcattctac  311341 ctatgtagtt atattattat tttggttagg ccagtataca ttattatgga cacacagtct  311401 tcacagctaa gccaagtagt aaactatgat acttgtgcat actttaaaat tttctcagga  311461 ttcataattc ataatttctc tttttaaaca ttttcttatt tttatatatg tttcagtgat  311521 gcatttaatt tccaaatctc tgctatttat tgagttatac tctcaatata ttcagacata  311581 ttgggttatc tgtccatttc atttccttag agaaatcttt cccagaatct tctgcacttc  311641 tccaatttca actagtgtgt gtctgggata cagctgtcat cctttcattt ttcttcactg  311701 tcattcaaca ggatctctgt cactttatcc tgttttggat actgtgtttt ccattttccc  311761 caacttcctc tcttttggtc tgctcacatt ttgccagtaa gaaagggtat gtgagaggca  311821 aattttctga gaccatgcct atctgaaatt gttcttctct tactctccct tttgactgat  311881 agtttggggg tcaaaaatac tcatctaatt atattagaaa taatatccct tcaaaatagt  311941 attttttcag aggtttccca tgccttttag attccacaat tgctcttgag tagtttaaag  312001 ccattgtgat tcttagtctt tcttgagcaa cttgtatttt tgattatctg tttggttttc  312061 caatctggaa agttctaggg tctccttatc tgcatgttca gaatttcatg atggtgtatc  312121 ttgcatggat ctatttttat tccttgtgta ctcatcaatg gacttttgct ctttggttga  312181 agggaatttt cttgaattgt ttacaaattc tttccatcca ttttctgttt tttttttttt  312241 catgtagaat ttctaattta tttttcatcc ttaaattccc tttgtctctt tgctttacct  312301 atgaacattt ccttatcttt aaattttaac atttctcttg gccttttcac ttttgctatc  312361 ataattttag tttctgcaag ctgttttgtt ctttaattct tcttttttaa acagcatgct  312421 gtttttgttt aatggctgca atggcttgtt ttgtctttat gagaatatta ataactcttt  312481 ttgatgtttc tttgcctttg atagtctgtt ttctctaagc tgttttgttc ttctttctcc  312541 cctgcttggt aattcccctg ctttgtgacc ctcagctcat atttcagggt aggatgcaaa  312601 ggtgggtttc gaagctttaa gcacatggat ggggcttgtg ggcagatcct cattggggga  312661 ctctgcctgg gctgccgctg aacccccatg tcagtatttt taggcttctc ctcttaagct  312721 gatcagattc ctcagaaaaa ttacttccga actcctgccc agagagtaaa gatttgcctg  312781 gcaaatctgt agcacctgag tgggaaaaac aacacgggtg gggctcagct ttcaacctac  312841 aaatgctcac ttagccccct ctttttactg cggcactcct tgtggtcttc taacccagaa  312901 gcatctctgt tttactcttt ttagaaaaaa ttattccagt cttctgccag attaaaggta  312961 gtgggggttg gggagcaatt attcatttgt accaagtgaa gccgatctca gactctaact  313021 gctgctgttt cgttttttaa taacccccac ccctttgccc caccaagctt gactgcttct  313081 taacagctaa aacatcctct ttgtattggt tccttacttc cagaggtacc tgttgctgca  313141 aattactgaa cgtttcagag attttatgtg taaattatgt tgcttactgt ctttttcctc  313201 ccctggctta gcttttcagt ttgttagaat tgataagtca ttatcattaa tctgtctgct  313261 ttccagcttc taaaattttg tcattgatgt ctcttcccct attctccccc tccttgcagg  313321 tttatgcaac cttctccatc ttcctcccca accccctcaa aatttcttga ctgtcatgtt  313381 tgtgaaaggg tgaaagttca attcaatgta tttacctccg cagtttaggc aaacctttgt  313441 atttcctaca ctaggagaac aatggtttta tgtccatctt cactctgttc atcccacagt  313501 gcttacctga ggtattattt tgaaatagag tctgggatgg agtctacctt agtgagaatt  313561 tattagaatt gtttagtctc tgcagaagat gaggtggttg aagcacatac atcacatata  313621 ctagcagtgc ttttgtataa tttaatatta tcaaattagt acttaagaat ggaaaattct  313681 gacttataag atctaaattc taattaaggc ttattgttat ctttattgtt ttaaatgata  313741 atataatgct atagcatgct attcatctga tattttttcc ataatgtgta tggccaccca  313801 gtaaacacct actgaatatc tactgaaaaa tgaggaactc ttttgttgga aaaatataaa  313861 atattcatca cataagcaat aatgtataaa tgttacaaaa aagtagtaca ttcattctgc  313921 cttgtttaga atatgtgaag cctttgcaaa ctaagaaaca tggaaatatt ttgaacatta  313981 aaatggtaaa tattatggga aagtagagca catttggaca atacagattt ctggccacct  314041 cattcagaac cattaagcac actgaaagct acgtttttat ttgcctcctg ttcatcttct  314101 ctctctctct ccttgttttt tttttttttt tttttctgtt ttgtgaacag ctgcagctgc  314161 tggtcgccag taataagtat cctgagagcc cagaaaaggt acactttgcc ttgctgttta  314221 aaagtaatgc aatatgtgaa cgcccagaga acaagcactg tggaactgct attttcctgt  314281 tctacccttg atggattttc aaggtcatgc tggccaatta aggcatcatc agtcctacct  314341 gagcaacaag aatctaaact ttattccaag tcagaaactg tttctgcaga gccactctct  314401 cccctgctcc atttcgtgac tttttttttt tttttaacaa attgagttta gaagtgagtg  314461 taatccagca atacagttta ctggtttagt tggtgggtta attaaaaaaa atttgctcat  314521 atgaactttc attttatatg tttcttttgc c 

Pejvakin (PJVK)

[0172] The PJVK gene encodes “pejvakin” (PJVK). PJVK is a member of the gasdermin family, and is required for the proper function of auditory pathway neurons. Mutations in PJVK may lead to non-syndromic sensorineural hearing loss. For example, a v.930_931del AC frameshift mutation in PJVK has been associated with deafness (Zhang et al., Acta Otolaryngol 135(3): 211-216, 2015).

[0173] The human PJVK gene is located on chromosome 2q231. It contains 8 exons encompassing ˜17 kilobases (kb) (NCBI Accession No. NG_012186.1). The full-length wildtype PJVK protein expressed from the human PJVK gene is 352 amino acids in length.

[0174] An exemplary human wildtype PJVK protein is or includes the sequence of SEQ ID NO: 51, SEQ ID NO: 53, SEQ ID NO: 55, SEQ ID NO: 57, SEQ ID NO: 59, or SEQ ID NO: 61. Non-limiting examples of nucleic acid encoding a wildtype PJVK protein are or include SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 58, SEQ ID NO: 60 and SEQ ID NO: 62.

TABLE-US-00017 Human PJVK Protein Isoform 1 (NCBI Accession No. NP_001036167.1) (SEQ ID NO: 51) MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAG ISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDH SLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFE LFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSM TDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK Human PJVK Isoform 1 cDNA (SEQ ID NO: 52) atgtttgctgctgctaccaagagctttgtcaagcaagttggagatggagggagattagttcctgttccaag cctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttccta gatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggt atttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaacca tattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagottcatttggtatag taaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccac agottgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccac acgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgoggtttcactttatggatgaac agaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagotttcagtgtttttgaa ctottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaaggga agaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatgg atgtcatttctcgttcacagotttacttggatgatcttttttctgactactatgacaaacctctcagcatg actgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggcc ttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgotttcagtgttctgttgatg gtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa Human PJIVK Protein Isoform 2 (NCBI Accession No. NP_001340704.1) (SEQ ID NO: 53) MAFAWDAAPLSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREI SAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKIN FDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFS VFELFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKP LSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK Human PJVK Isoform 2 cDNA (SEQ ID NO: 54) atggcgtttgcctgggatgcagcacctttgagotttgtcaagcaagttggagatggagggagattagttcc tgttccaagcctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttc tgtttcctagatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatt tcagctggtatttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcg aggtaaccatattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagcttcat ttggtatagtaaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaac tttgaccacagottgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcat ccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcacttta tggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagt gtttttgaactcttcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatt tgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaa gagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacct ctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcc caaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgtt ctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaa taa Human PJVK Protein Isoform 3 (NCBI Accession No. NP_001340705.1) (SEQ ID NO: 55) MYVYRLLSITVLMDILLEGLHSQYFTIYELRITPMAKHFSTQSFVKQVGDGGRLVPVPSLSEADKYQPLSL VVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGS DSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIR GEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDRRVMDVISRSQLYLDDLFSDYYDKPL SMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK Human PJVK Isoform 3 cDNA (SEQ ID NO: 56) atgtatgtatatagattactatccatcactgttttaatggatatcttattggaagggctacatagtcagta tttcacaatatatgaactccgcataacacctatggcaaaacatttcagcactcagagotttgtcaagcaag ttggagatggagggagattagttcctgttccaagcctcagtgaagctgacaaatatcaacctctaagtctg gtggtaaaaaagaagcgatgotttctgtttcctagatataaatttacttcaacaccttttacactgaaaga tattctcctaggagacagagaaatttcagctggtatttcatcttatcaattactgaattatgaagatgaat cagatgtttcactctatggaaggcgaggtaaccatattgtaaatgacgttgggattaacgttgctggatca gattccattgcagtgaaagottcatttggtatagtaaccaaacatgaagtggaagtatcaacattactcaa agaaattactacacgaaaaattaactttgaccacagottgatacgtcagtcaaggagcagcagaaaggcag tattgtgtgtggtcatggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcga ggggaagcaatgoggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttccc agcacatacaaccatagotttcagtgtttttgaactottcatatacctggatggtgcctttgatagaagag tgatggatgtcatttctcgttcacagotttacttggatgatcttttttctgactactatgacaaacctctc agcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaa agggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgotttcagtgttctg ttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa Human PJVK Protein Isoform 4 (NCBI Accession No. NP_001340706.1) (SEQ ID NO: 57) MESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVS KGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLN HNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK Human PJVK Isoform 4 cDNA (SEQ ID NO: 58) atggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcg gtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaacca tagotttcagtgtttttgaactottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtca aaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttga aagaaatagaagagtgatggatgtcatttctcgttcacagotttacttggatgatcttttttctgactact atgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaat cacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtg ctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcaca agaggatgaaataa Human PJVK Protein Isoform 5 (NCBI Accession No. NP_001340707.1) (SEQ ID NO: 59) MESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVS KGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLN HNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK Human PJVK Isoform 5 cDNA (SEQ ID NO: 60) atggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcg gtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaacca tagotttcagtgtttttgaactottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtca aaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttga aagaaatagaagagtgatggatgtcatttctcgttcacagotttacttggatgatcttttttctgactact atgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaat cacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtg ctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcaca agaggatgaaataa Human PJVK Protein Isoform 6 (NCBI Accession No. NP_001356841.1) (SEQ ID NO: 61) MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAG ISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDH SLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFE LFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSM TDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK Human PJVK Isoform 6 cDNA (SEQ ID NO: 62) atgtttgctgctgctaccaagagctttgtcaagcaagttggagatggagggagattagttcctgttccaag cctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttccta gatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggt atttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaacca tattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagottcatttggtatag taaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccac agottgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccac acgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgoggtttcactttatggatgaac agaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagotttcagtgtttttgaa ctottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaaggga agaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatgg atgtcatttctcgttcacagotttacttggatgatcttttttctgactactatgacaaacctctcagcatg actgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggcc ttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgotttcagtgttctgttgatg gtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa

[0175] In some embodiments of any of the compositions described herein, the PJVK protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 51.

[0176] In some embodiments of any of the compositions described herein, the PJVK protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 53.

[0177] In some embodiments of any of the compositions described herein, the PJVK protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 55.

[0178] In some embodiments of any of the compositions described herein, the PJVK protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 57.

[0179] In some embodiments of any of the compositions described herein, the PJVK protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 59.

[0180] In some embodiments of any of the compositions described herein, the PJVK protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 61.

[0181] A non-limiting example of a human wildtype PJVK genomic DNA sequence is SEQ ID NO: 63. The exons in SEQ ID NO: 63 are: nucleotide positions 5001-5334 (exon 1); nucleotide positions 6953-7185 (exon 2) and nucleotide positions 7897-8092 (exon 3); nucleotide positions 8281-9208 (exon 4); nucleotide positions 9575-9716 (exon 5); nucleotide positions 12075-12192 (exon 6); nucleotide positions 13913-14011 (exon 7); and nucleotide positions 14547-15131 (exon 8). The introns in SEQ ID NO: 63 are: nucleotide positions 1-5000 (intron 1); nucleotide positions 5335-6952 (intron 2); nucleotide positions 7186-7896 (intron 3); nucleotide positions 8093-8280 (intron 4); nucleotide positions 9209-9574 (intron 5); nucleotide positions 9717-12074 (intron 6); nucleotide positions 12193-13912 (intron 7); and nucleotide positions 14012-14546 (intron 8).

TABLE-US-00018 Human PJVK Gene Sequence (NCBI Reference Sequence: NG_012186.1) (SEQ ID NO: 63)     1 tttcttgccg ggagagaggg attagaggga ttgtcoggcg tgggtctagg gtcgttgagg    61 cctaaagtta agcctttgtg gggaggacgg attgggggct gggtcacttt aagaaaaaga   121 ttctaaaatt acgaaggcag aattccaggg agtctccojg gcctggtcct gaagcttgag   181 accccggata tatacgctcc agggggctgc ggtgcgctct tcgggtcccc gagccctgtg   241 tttaggaaca cgoggggacg tccaaacacc cgctoctotc ccgccgggcg ggctcctttg   301 tcttctgggc tttcgtcgcg agatggaacg ctgggtcagt gcatcccagc aaaacacgtt   361 aggagtaaac gaaggccttt cojgggacct gggtagtojg ttgtaatggc gtttgcctgg   421 gatgcagcac ctttggtggg ccattagatg acgtgtcgct tctccagggg cttgctaggc   481 actagcagaa atgctcccct gtgcttactc ggtgttatgg aagattgctt gcacaatgct   541 attcgtacga aaggatatta ttaaaagtga tttatgggcg ggcgcggtgg ctcacgcctg   601 taatcccagc actttaggag gccgaggctg gcggatcgcc tgaagtaagc agttcgagac   661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agccgggcgt   721 ggtggcatgc gcctgtaatc ccagctactc gggaggctaa agcaggagaa tcgcttgaac   781 cojggaggca aabittgcag tgagccgaga tcgcgccact gcactccagc ctgggcgaca   841 gagtcagact ccctctcaaa aaaaaaaaaa aaaaaaaaag cgatttgttg ttttgttagc   901 atgtaagccc tggatgcttg aaacaagtga aagatgttca gaatctaatc aaattatatc   961 atctgatgct ttaattagag cctattctct cttcctctcc gtctatatat gtatgtatat  1021 agattactat ccatcactgt tttaatggat atcttattgg aagggctaca tagtcagtat  1081 ttcacaatat atgaactccg cataacacct atggcaaaac atttcagcac tcaggtaaaa  1141 ttcatttttt gccacaaaat tacttaaaaa caggccagaa ctttatatag ctcttgttaa  1201 aggttaagta gcbjggataa taatgaaaca aaaagatgca gcaggactcc atttcaaaga  1261 gagagagtct gtgtgcccaa cttcagagta agaaaccact aggtaatagt ttatatagtt  1321 acttatatgt aatgtggctt tattttttaa ataaagattt gcatataatt gtttatatct  1381 gtgaatttat atttaatatt aaacacagtt ttgtaagcat ataagatgga aaatgaatga  1441 aatgctcaat caatgagctg tatgccatga ggattcaaaa cagcactttg gtgttgccaa  1501 aattccggtg gtggacttgt gaaggaattc cctttggact aggtccactg tagattgtat  1561 cojggactat cgttagtgcc taaattgcat tgcttcccac agcactatat gcttccctta  1621 aaattggccc attgccagtg gcaaatcact atctactgtg atccttatca tagacattgg  1681 tcatattttt acgttattag ttttctgtgt atattttagt gctatagcct gccattccaa  1741 gttaaacatg ctcttagcat atcattttac accgttgatc tataattcat tacctgagca  1801 catgagcaga ggcagggaat tatacagtgg taaactactt ggtgaaacca tgctttgtat  1861 ttttaagatg tataattata tttaaaaaca agcaatgctt aattttgtgc ctgattttcc  1921 tctttaaaaa tggatttatc tgggggttgc agttgatgac gttttgattt taatatgttt  1981 gctgctgcta ccaagagctt tgtcaagcaa gttggagatg gagggagatt agttcctgtt  2041 ccaagcctca gtgaagctga caaatatcaa cctctaagtc tggtggtaaa aaagaagcga  2101 tgctttctgt ttcctagata taaatttact tcaacacctt ttacactgaa agatattctc  2161 ctaggagaca gagaaatttc agctggtaag tttaaatgtt tgggagtgcc aactcattca  2221 tctgtattat tggcaaccta aacataggtc atatatgcta cttatgttag taatacacat  2281 tttcaatgat taaagcaact tttattatga bittagtgta ataacattat taagattaac  2341 aatgccaaaa gtttgtataa tatcaaatct cttattggtc aaataatttt caaatctatc  2401 aattatttta taaattgttt taaccaaatc aacttagaat atgacatatt tcttcatcta  2461 taaaatggga tattatttgg gcttacctat gttacatggt caaatgagat gaaaataatt  2521 tgtatttatt ttttacaatt caattattac aattggtaaa ctgaaatgta ttgaagggta  2581 ggttatataa taagctgata ttttgatgag ttactactta taaacgctta ttttttcttt  2641 taattgcccg gtggatcttg atgcttaaga agttctgttg gctgaataga aaatttgagt  2701 tccttttaag aattctggct atgtgtttct ttttgttgta agattaattg aattactact  2761 ttaagtcttg gtgagtcatg ttgcctttct ctaacatttg ggtatttgag tcttcaattg  2821 ttaatttaac atgttactat atataatcta cataagataa agatgtttaa aaaatactga  2881 gtttcttctt ataaaggtat ttcatcttat caattactga attatgaaga tgaatcagat  2941 gtttcactct atggaaggcg aggtaaccat attgtaaatg acgttgggat taacgttgct  3001 ggatcagatt ccattgcagt gaaagcttca tttggtatag taaccaaaca tgaagtggaa  3061 gtatcaacat tactcaaaga aattactaca cggtcagtat aataatccta atatatttca  3121 gtgttttcat taaatacttt aggtatataa acttcattac aaagaatgct taaaacattg  3181 aggttgtatt ttactagtgt aatttgctag atatgtttga aatacattgg tagtatatcc  3241 aaactttgaa taaggataga tatcaaaaat cacttggctg aagtcagaga cctcagggcc  3301 ccagatcaag gagctaactg atgaagaggc agagaggctg cagctagaga ttgaccagaa  3361 ataggatgca gagaatcatg aggcccagat caagaatggc agccttgact ccccagggaa  3421 gcagaagact gaggaagatg aggaggagga agatgagaag gacaaaggaa aactgaagcc  3481 caacctaggc aacagggcag acctgcctga ttaccgctgg accaagaccc tgtcggagct  3541 ggacctggcg gtccctttct gtgtggactt ccagctgaaa gggaaggacg tggtggtggc  3601 atccaacggc ggcacctcca ggtggggctc aaggggcagc cagcgatcat cgatggggag  3661 ctctacaacg aagtgaaggc ggaggagagc tcgtggctca ttgaggacgg caaggtggtg  3721 actgtgcatc tggagaagat caagaagatg gagtggtgga gccgcttggt gtccagtgac  3781 cctgagatca ataccaagaa gattaaccct gagaattcca agctgtcaga cctggacagt  3841 gagactcaca tcatggtgga aaagacaatc tatgaccagt aacagaagtc catggggctg  3901 ccaacctcag acgaacagaa gaaacaggag attctgaaga agttcatgga tcagcatccg  3961 gagatggatt tttccaaggc taaattcaac tagcccctgt ttttccctcc ctgaactctt  4021 ggggctgagc tgcaaccacc caactttctt tcccactctt ctctgggact tgtgggcctc  4081 agggcttggg gcaggcatgg gactggccca ggcacacagg tcccagggca tcaggagaaa  4141 ggctggggct tggggtcttg tcctccccag ttggcctact gttacacatt aaaatgattt  4201 gcccagctaa aaaaaaaaaa aaaccacttg gcttaaacaa aacttttaat tgttccacaa  4261 aattactttg gctctacaca catttgctta attattagat ttaaataata cagcaatctg  4321 tctgcaacaa atagagtccc cttcaacaga ctttcaacag acagagtgaa acattctgca  4381 taagcatgtt ttaagaaaat agagaggaga gacaaattat tacatttctt ttgggtgtat  4441 tttctgacta ttaggattgc cttgatttac tattaggtga actatgaatg aataacacat  4501 gatagcaaaa aatgtatttg attatgtgta attagatgtt atagagtctt gtgaatgtat  4561 cttctttatt ttagaaaaat taactttgac cacagcttga tacgtcagtc aaggagcagc  4621 agaaaggcag tattgtgtgt ggtcatggag agcatccgaa ccacacgaca gtgctcactg  4681 tctgtgcatg ctggaattcg aggggaagca atgcgggtaa accacacttg ttgggttctc  4741 ttactaacta aagtgttgcc atgggaattt ttttaagtat tgaatttcta gtcaggcttg  4801 tgtattttgt gaaatgttct gatgaaagag ctgcagttgt ataggatttt gcacagcaat  4861 gtctgttcta gaatatgaaa aaaaaaaaca aatcttggga ttctaaacat gtgtaatata  4921 atgcaaaaac agtaatcctt gtgaaattac gtgcatactg gagtccctca agttactatt  4981 taagtgttgt tttaagaata aaaattgagt gagttgaatt gattttattt ttaagtgata  5041 cagtttttga ctgggcacag tggctcacgc ctgtaatcct agcattttgg gaggccgagg  5101 tgggcggatc acttgcagtc aggagttgga gatcaagttg ggcaacacag agaaacccca  5161 tctctactga aaatacaaaa attagccagg tgtggtggta cacccctgta atcccaagcc  5221 actcaggaag ctgaggcaca agaatcactt gaacctggga ggtggaggtt gcagtgagcc  5281 gagattgtgc cattgcactc taacctgggt ggcagagtga gactccgtct caaaaaaaca  5341 aaacaaaaca aaaaccccaa ccaaaaaaaa aatgtgtaac ataatgcaaa aacagtaatc  5401 cttgtgaaat tacatgcata ctggagtccc tcatattact atttaagtgc tgttttaaga  5461 ataaaaattg agtgcttaag ttgaattgat ttaagtgata gagtttttac actttgaatt  5521 ttttaaagct gaatttatag attttttttt tgagacggag tctcgctctg tccccgaggc  5581 tggagtgcag tggcgcgatc ttggctcact gcaaactccg cctccojggt tcatgccatt  5641 cttctgcctc agcctcccga gtagcbjgga ctacaggcac ctgccaccac gcccggcagt  5701 gttatccagg atggtttcga tctcctgacc tcgtgatccg ctagcctojg cctcccaaaa  5761 tgctgggatt acaggtgtga gccaccgcgc ctggcctgaa tttatatttt tatattcaaa  5821 tagtttttca aagttaatat tatcaatggc catacatgct ttattcaagg ttagttaaat  5881 cctttaaaaa atattagcgg caaggtgcag tggatcatgc ctgtaatccc agtgcttagg  5941 aagactgaga taggaagaca gcttgggacc aggagttcaa gaccaacttg agcaaaataa  6001 tgagaccttg tctctacaaa aaataaaaga attagctggt tgtggtggca catgcctata  6061 gtcccagcta ctcggaaggc tgaggcaggg ggctgcctgc ggggtttggg tcattgtctt  6121 ttagaatttg ggaggctttg aaaagccgtg cttttgtgct ggggaagatg tagcagtctc  6181 ttctccaaac cacccatttg ccttcggact tctctggggc cagcagccat ccaactaggg  6241 gccojgggcc acgggctcag ctgacgacca tgggcttcgc gtccaaccag cagtttgcag  6301 gttcgagctc aggacttggc ggggacacct taggatgcag gagtggccag gagttcaagg  6361 ttacagtagg ctatgattgt gccactgctc tccagcctgg gtgacagaga gagaccctgt  6421 ctctgaaaaa aaaattggaa aagtatctgt gtttaatttt cagctcaatt atgatattgt  6481 ttatctttgt cattcagtga cacctaataa tgacttgatt ggattaaaac caattgttag  6541 aaagataggg ttcaaggata atcttttcaa gtctttgcaa ataaaagtta ttttcgcata  6601 ttcagctgcc tgtcaaattc tgattaacat tggatcattt ttgaggcaca aactgaaaca  6661 tttacttgat tgttagcgat tgctttagaa agctactaaa agctctggag ggctttggaa  6721 tggtagacag gctaggctga aaactttaac tctggcactg ctttctaaga tttcctgtta  6781 aaaaaaaaaa aaaggcttct gctccagagc attatggttg tggtagcact aatcatgggc  6841 tgtaatacca aagtaagtga aaagtgcaga ggtatttcct aatatagacc aggagtttct  6901 gttggaccaa ttggatctct gctataaaaa atggtttaat tcaagcagaa taatccttta  6961 cttgggaatt ttttgttttg tttttggtag gattatagga aatgtttcat ttctccaaaa  7021 agctatcctt acatgttatg atccttaatt atgttattta tttattcaat atagtttcac  7081 tttatggatg aacagaatcc caagggaagg gacaaagcta ttgttttocc agcacataca  7141 accatagctt tcagtgtttt tgaactcttc atatacctgg atggtgcctt tggtgagtta  7201 agggtctgca tgaaatacaa atgattatat ttttaaggag cattcattag ggcatgtgct  7261 ctctctctct cttttctctc atttctcgtg tctaacaatt atagaagatg ctctcagcac  7321 tgtcaatctt atgctttggc aaaatagctg agaaagaccc tccgttcgct gcttccccat  7381 tccacttttc tgcttcttgg tgaaggttgt aaactctcca ctaccccatt taaaattata  7441 aataagagct aaaatgccat ctactgacaa agtattcctt agcttacatg gggagataat  7501 aaatgacctt cttataggta gtttttgatg gtggcaaaca gaggagtagg tagatagtag  7561 gatgcctgaa gtgttaggat gcccaaacca gggcctctaa agacagcttt tcttacttca  7621 gttttactta tcatagaccc agcttcccct tgcactcttc ctaaaaaata actttaaaaa  7681 gtgaaaatac ttcctccaaa attgtcacct tgtataatac ctaagtgcag ctcactttag  7741 gtctctacat ttcacaggtc tttaaggtct gttggccaac tggaacaagt ccaggtgtag  7801 cccaagggat caggaaaggc agcccctagc catggtaatt tacaaatgtt tttagacctg  7861 ttcttgttca tttctgcaat tttgtaggag gagggaatag ggagtccaga aacaaaacaa  7921 aactacatgt taagtaaatt gtctttttaa aaaatatttt taatttttgt ggctatatag  7981 tagattatat atatatttat gtatgggata catgaggtat tttgatacgg gcatacagtg  8041 cataataatc acatcatgga aaatggggta tccatcccct caagcattta tcctttgtgt  8101 tacaaacaat ccaattatac tcttttagtt atttaaaaat gtacaaattc tcagtctaag  8161 atggagaaaa aactgtacaa ttacattatt ttgactgtag tcaccctatt atgcttccaa  8221 atactaggtc ttattaagta aattctaatt ggataacttt aggtttttac agttttattg  8281 atggttggga ggaatgtaaa tggactgata tatccacaag aatttaaaat atatatataa  8341 tttggacttc cacttctagg aatttatcct acagatatat ttacacatat atgaaatgat  8401 atgagtgcaa gtatattcag tcctcaataa caagagattg gaaacaacat taaggagact  8461 aaataatggt gcatccttgc aagagaatac tatgaagcca ataagaatat aatactttta  8521 atagatattt ttcaagagct gagtataata tgtaactatt tgggcataaa taattttata  8581 cacatacatg tatatatgca tctttcttta tgcttataaa atatatggag tatttctgga  8641 agcaaacata agaaacttaa accacgggtg cccctaagcc cctgaggtag aagactgtgg  8701 ctggatacag ggtgggccag agacctattt gtcactgtat ctcctttctg tatgaatttt  8761 gtaccatgtg aatgttacct tttccaaaag tatgtaaaag tcaactttta aaaacaatac  8821 aatgaatgat ttgtactaga attcatcacc ccatcaaaca ataaaatatg aattattcaa  8881 gttataacat cttctaacaa ttttttttgt agacctttgt gtcacttcag tgtcaaaagg  8941 aggatttgaa agggaagaaa cggcaacatt tgcactgctg tacaggttga gaaatatcct  9001 atttgaaaga agtatgttta ttgaagagta ctgtgaatgt cttttttttt tctttcctgg  9061 cttaacacat gaggttttct attcagtaat ctcatctgtt aaggaaaaat ttaaatttaa  9121 aagcctggct ggtatggtgg ctcatgccta taatcccagc actttgggag gccagggcag  9181 gcagattgct agcactcaga agtttgaaac acttgggcaa tgtgagaaaa ccccatctgt  9241 acaaagaata caaaagaaaa aaaattagtt ggttgcagtg gtgtgcacct gtagtcccag  9301 ctacttgaga ggctgaggta ggaggatcac ttgagcgtgg gaggcggagg ttgtagtaag  9361 tggagattgt gccactgccc tccagottgg gtgacagagc cagaccctgt ctcaaaaaaa  9421 aaaaaaaaaa aaaaaaagcc aaattatttc atgactagtg gattcacata tttattaatg  9481 ctgtttgcat tatgtatttt tcattttcac ttctaacaca tttcttttct gtttttgtcc  9541 ttttagatag aagagtgatg gatgtcattt ctcgttcaca gctttacttg gatgatcttt  9601 tttctgacta ctatgacaaa cctctcagca tgactgatat ttcactcaaa gaagggaccc  9661 atatccgagt taacttactt aatcacaaca ttcccaaagg gccttgcata ctctgtggaa  9721 tggggaactt caaaagggag acagtttatg ggtgctttca gtgttctgtt gatggtcaga  9781 agtatgtgag acttcatgca gttccttgtt ttgatatttg gcacaagagg atgaaataaa  9841 atgaaaaatg aatacaccgt gttggtgttt taggtgcagt tgtgccacaa accttcccta  9901 aattatctag gtttgctttg atgaattaaa ttaaaatgag aaaagcaaaa agaaattaac  9961 ctgtctgggt atcatattcc ctatctataa agtagcaatt ataacagtag tgtctatttc 10021 ttaagttgtc atgaaaatta ataacattgt ttatatcaaa aaagatttac atataaaatt 10081 cagagattat gaatcatgcc agtcacttta gaatcatttt tgggatgtag t

Heat Shock Protein Family a (Hsp70) Member 1A (HSPA1A)

[0182] The HSPA1A gene encodes “heat shock protein family A member 1A” (HSPA1A). The human HSPA1A gene is located on chromosome 6p21.33. It contains 1 exon, encompassing ˜2400 bp (NCBI Accession No. NC_000006.12). HSPA1A encodes a 70 kDa heat shock protein, which stabilizes proteins against protein aggregation and is involved in protein folding.

[0183] Exemplary wildtype HSPA1A protein sequences are or include SEQ ID NO: 64, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, and SEQ ID NO: 93. Exemplary DNA sequences that encode a NDP protein are shown below.

TABLE-US-00019 Human Mature HSPA1A Protein (NCBI Accession No. NP_005336.3) (SEQ ID NO: 64) MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK RLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNA VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID DGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI DSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ IFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK ANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK KVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEE VD Human Mature HSPA1A cDNA (SEQ ID NO: 65) atggccaaagccgcggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacgg caaggtggagatcatcgccaacgaccagggcaaccgcaccaccoccagctacgtggccttcacggacaccg agoggctcatcggggatgcggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaag cggctgatcggccgcaagttcggcgaccoggtggtgcagtoggacatgaagcactggcctttccaggtgat caacgacggagacaagcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggaga tctcgtccatggtgctgaccaagatgaaggagatcgccgaggcgtacctgggctaccoggtgaccaacgcg gtgatcaccgtgccggcctacttcaacgactcgcagcgccaggccaccaaggatgogggtgtgatcgcggg gctcaacgtgctgoggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggca agggggagcgcaacgtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgac gacggcatcttcgaggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggct ggtgaaccacttcgtggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtga ggcggctgcgcaccgcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatc gactocctgtttgagggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccga cctgttccgaagcaccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattc acgacctggtoctggtogggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaac gggcgcgacctgaacaagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccat cctgatgggggacaagtccgagaacgtgcaggacctgctgctgctggacgtggctoccctgtcgctggggc tggagacggccggaggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcag atcttcaccacctactccgacaaccaaccoggggtgctgatccaggtgtacgagggcgagagggccatgac gaaagacaacaatctgttggggcgcttcgagctgagoggcatccctccggcccccaggggcgtgccccaga tcgaggtgaccttcgacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaag gccaacaagatcaccatcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcagga ggcggagaagtacaaagoggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcct acgccttcaacatgaagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaag aaggttctggacaagtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtt tgagcacaagaggaaggagctggagcaggtgtgtaaccccatcatcagoggactgtaccagggtgccggtg gtccogggcctgggggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggag gtggattag Human Mature HSPA1A cDNA (SEQ ID NO: 94) atgtaccggatgcagctgctgagctgtatcgccctgtctctggccctggtcaccaattctgccaaagccgc ggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacggcaaggtggagatca tcgccaacgaccagggcaaccgcaccaccoccagctacgtggccttcacggacaccgagcggctcatcggg gatgoggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaagoggctgatcggccg caagttcggcgacccggtggtgcagtcggacatgaagcactggcctttccaggtgatcaacgacggagaca agcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggagatctcgtccatggtg ctgaccaagatgaaggagatcgccgaggcgtacctgggctacccggtgaccaacgcggtgatcaccgtgcc ggcctacttcaacgactcgcagcgccaggccaccaaggatgcgggtgtgatcgcggggctcaacgtgctgc ggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggcaagggggagcgcaac gtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgacgacggcatcttcga ggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggctggtgaaccacttcg tggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtgaggcggctgcgcacc gcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatcgactccctgtttga gggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccgacctgttccgaagca ccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattcacgacctggtcctg gtcgggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaacgggcgcgacctgaa caagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccatcctgatgggggaca agtccgagaacgtgcaggacctgctgctgctggacgtggctcccctgtcgctggggctggagacggccgga ggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcagatcttcaccaccta ctccgacaaccaacccggggtgctgatccaggtgtacgagggcgagagggccatgacgaaagacaacaatc tgttggggcgcttcgagctgagcggcatccctccggcccccaggggcgtgccccagatcgaggtgaccttc gacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaaggccaacaagatcac catcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcaggaggcggagaagtaca aagcggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcctacgccttcaacatg aagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaagaaggttctggacaa gtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagagga aggagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctggg ggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggaggtggattaa

[0184] In some embodiments of any of the compositions described herein, the HSPA1A protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 64.

[0185] In some embodiments of any of the compositions described herein, the HSPA1A protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 66.

[0186] In some embodiments of any of the compositions described herein, the HSPA1A protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 68.

[0187] In some embodiments of any of the compositions described herein, the HSPA1A protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 69.

[0188] In some embodiments of any of the compositions described herein, the HSPA1A protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 70.

[0189] In some embodiments of any of the compositions described herein, the HSPA1A protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 94.

TABLE-US-00020 Mouse Mature HSPA1A Protein (NCBI Accession No. NP_034609.2) (SEQ ID NO: 66) MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK RLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEAYLGHPVTNA VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID DGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI DSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFN GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ TFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK ANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKK KVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPKGASGSGPTIEE VD Mouse Mature HSPA1A cDNA (SEQ ID NO: 67) atggccaag aacacggcga tcggcatcga cctgggcacc acctactcgt gcgtgggcgt gttccagcac ggcaaggtgg agatcatcgc caacgaccag ggcaaccgca cgacccccag ctacgtggcc ttcaccgaca ccgagcgcct catcggagac gccgccaaga accaggtggc gctgaacccg cagaacaccg tgttcgacgc gaagcggctg atcggccgca agttcggcga tgcggtggtg cagtccgaca tgaagcactg gccottccag gtggtgaacg acggcgacaa goccaaggtg caggtgaact acaagggcga gagccggtog ttottccogg aggagatctc gtccatggtg ctgacgaaga tgaaggagat cgctgaggcg tacctgggcc acccggtgac caacgcggtg atcacggtgc ccgcctactt caacgactct cagojgcagg ccaccaagga cgcgggcgtg atcgccggtc taaacgtgct gcggatcatc aacgagccca cggcggccgc catcgcctac gggctggacc ggaccggcaa gggcgagcgc aacgtgctca tcttcgacct ggggggcggc acgttcgacg tgtccatcct gacgatcgac gacggcatct tcgaggtgaa ggccacggcg ggcgacacgc acctgggagg ggaggacttc gacaaccggc tggtgagcca cttcgtggag gagttcaaga ggaagcacaa gaaggacatc agccagaaca agcgcgcggt gojgcggctg cgcactgcgt gtgagagggc caagaggacg ctgtcgtcca gcacccaggc cagcctggag atcgactctc tgttcgaggg catcgacttc tacacatcca tcacgcgggc gog-gttcga gagctgtgct cagacctgtt ccgcggcacg ctggagcccg tggagaaggc cctgcgcgac gccaagatgg acaaggcgca gatccacgac ctggtgctgg tgggcggctc gacgcgcatc cccaaggtgc agaagctgct gcaggacttc ttcaacgggc gcgacctgaa caagagcatc aaccoggacg aggcggtggc ctacggggcg goggtgcagg cggccatcct gatgggggac aagtojgaga acgtgcagga cctgctgctg ctggacgtgg cgccgctgtc gctgggcctg gagactgcgg gojgcgtgat gacggcgctc atcaagcgca actccaccat ccccaccaag cagacgcaga ccttcaccac ctactcggac aaccagcccg gggtgctgat ccaggtgtac gagggcgaga gggccatgac gcgcgacaac aacctgctgg ggcgcttcga actgagojgc atcccgccgg cgcccagggg cgtgccacag atcgaggtga ccttcgacat cgacgccaac ggcatcctga acgtcacggc caccgacaag agcaccggca aggccaacaa gatcaccatc accaacgaca agggccgcct gagcaaggag gagatcgagc gcatggtgca ggaggccgag cgctacaagg ccgaggacga ggtgcagcgc gacagggtgg ccgccaagaa cgcgctcgaa tcctatgcct tcaacatgaa gagcgccgtg gaggacgagg gtctcaaggg caagctcagc gaggctgaca agaagaaggt gctggacaag tgccaggagg tcatctcctg gctggactcc aacacgctgg ccgacaagga ggagttcgtg cacaagojgg aggagctgga gojggtgtgc agccccatca tcagtgggct gtaccagggt gojggtgctc ctggggctgg gggcttoggg gcccaggcgc ccaagggagc ctctggctca ggacccacca tcgaggaggt ggattaga Rhesus Monkey Mature HSPA1A Protein (NCBI Accession No. XP_014991489.2) (SEQ ID NO: 68) MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK RLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNA VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTEDVSILTID DGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI DSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ IFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK ANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK KVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEE VD Rat Mature HSPA1A Protein (NCBI Accession No. NP_114177.2) (SEQ ID NO: 69) MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK RLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNA VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID DGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI DSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ TFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK ANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKK KVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKGGSGSGPTIEE VD Cattle HSPA1A Protein (NCBI Accession No. NP_976067.3) (SEQ ID NO: 70) MAKNMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK RLIGRKFGDPVVQSDMKHWPFRVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGHPVTNA VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID DGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI DSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ IFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK ANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK KVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISRLYQGAGGPGAGGFGAQGPKGGSGSGPTIEE VD Human Mature HSPA1A Protein (SEQ ID NO: 93) AKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKR LIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAV ITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDD GIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEID SLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNG RDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQI FTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKA NKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKK VLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEV D

[0190] A non-limiting example of a human wildtype NDP genomic DNA sequence is SEQ ID NO: 71.

TABLE-US-00021 Human HSPA1A Gene Sequence(NCBI Reference Sequence NC_00000612) (SEQ ID NO: 71) 1 aacggctagc ctgaggagct gctgcgacag tccactacct ttttcgagag tgactcccgt   61 tgtcccaagg cttcccagag cgaacctgtg cggctgcagg caccggcgcg tcgagtttcc  121 ggcgtccgga aggaccgagc tcttctcgcg gatccagtgt tccgtttcca gcccccaatc  181 tcagagcgga gccgacagag agcagggaac cggcatggcc aaagccgcgg cgatcggcat  241 cgacctgggc accacctact cctgoitggg ggtgttccaa cacggcaagg tggagatcat  301 cgccaacgac cagggcaacc gcaccacccc cagctacgtg gccttcacgg acaccgagcg  361 gctcatcggg gatgojgcca agaaccaggt ggcgctgaac ccgcagaaca ccgtgtttga  421 cgcgaagcgg ctgattggcc gcaagttcgg cgaccoggtg gtgcagtojg acatgaagca  481 ctggcctttc caggtgatca acgacggaga caagcccaag gtgcaggtga gctacaaggg  541 ggagaccaag gcattctacc ccgaggagat ctcgtccatg gtgctgacca agatgaagga  601 gatcgccgag gcgtacctgg gctaccoggt gaccaacgcg gtgatcaccg tgccggccta  661 cttcaacgac tcgcagcgcc aggccaccaa ggatgojggt gtgatcgcgg ggctcaacgt  721 gctgcggatc atcaacgagc ccacggccgc cgccatcgcc tacggcctgg acagaacggg  781 caagggggag cgcaacgtgc tcatctttga cctgggcggg ggcaccttcg acgtgtccat  841 cctgacgatc gacgacggca tcttcgaggt gaaggccacg gccggggaca cccacctggg  901 tggggaggac tttgacaaca ggctggtgaa ccacttcgtg gaggagttca agagaaaaca  961 caagaaggac atcagccaga acaagcgagc cgtgaggcgg ctgcgcaccg cctgcgagag 1021 ggccaagagg accctgtcgt ccagcaccca ggccagcctg gagatcgact ccctgtttga 1081 gggcatcgac ttctacacgt ccatcaccag ggcgaggttc gaggagctgt gctccgacct 1141 gttccgaagc accctggagc ccgtggagaa ggctctgcgc gacgccaagc tggacaaggc 1201 ccagattcac gacctggtcc tggtoggggg ctccacccgc atccccaagg tgcagaagct 1261 gctgcaggac ttcttcaacg ggcgcgacct gaacaagagc atcaaccccg acgaggctgt 1321 ggcctacggg gojgcggtgc aggcggccat cctgatgggg gacaagtccg agaacgtgca 1381 ggacctgctg ctgctggacg tggctcccct gtcgcbgggg ctggagacgg ccggaggcgt 1441 gatgactgcc ctgatcaagc gcaactccac catccccacc aagcagacgc agatcttcac 1501 cacctactcc gacaaccaac cojgggtgct gatccaggtg tacgagggcg agagggccat 1561 gacgaaagac aacaatctgt tggggcgctt cgagctgagc ggcatccctc cggcccccag 1621 gggcgtgccc cagatcgagg tgaccttcga catcgatgcc aacggcatcc tgaacgtcac 1681 ggccacggac aagagcaccg gcaaggccaa caagatcacc atcaccaacg acaagggccg 1741 cctgagcaag gaggagatcg agcgcatggt gcaggaggcg gagaagtaca aagcggagga 1801 cgaggtgcag cgcgagaggg tgtcagccaa gaacgccctg gagtcctacg ccttcaacat 1861 gaagagcgcc gtggaggatg aggggctcaa gggcaagatc agcgaggcgg acaagaagaa 1921 ggtgctggac aagtgtcaag aggtcatctc gtggctggac gccaacacct tggccgagaa 1981 ggacgagttt gagcacaaga ggaaggagct ggagcaggtg tgtaacccca tcatcagcgg 2041 actgtaccag ggtgccggtg gtcccgggcc tgggggcttc ggggctcagg gtcccaaggg 2101 agggtctggg tcaggcccca ccattgagga ggtagattag gggcctttcc aagattgctg 2161 tttttgtttt ggagcttcaa gactttgcat ttcctagtat ttctgtttgt cagttctcaa 2221 tttcctgtgt ttgcaatgtt gaaatttttt ggtgaagtac tgaacttgct ttttttccgg 2281 tttctacatg cagagatgaa tttatactgc catcttacga ctatttcttc tttttaatac 2341 acttaactca ggccattttt taagttggtt acttcaaagt aaataaactt taaaattcaa Human HSPA1A Gene Sequence (SEQ ID NO: 94) atgtaccggatgcagctgctgagctgtatcgccctgtctctggccctggtcaccaattctgccaaagccgc ggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacggcaaggtggagatca tcgccaacgaccagggcaaccgcaccacccccagctacgtggccttcacggacaccgagcggctcatcggg gatgcggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaagcggctgatcggccg caagttcggcgacccggtggtgcagtcggacatgaagcactggcctttccaggtgatcaacgacggagaca agcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggagatctcgtccatggtg ctgaccaagatgaaggagatcgccgaggcgtacctgggctacccggtgaccaacgcggtgatcaccgtgcc ggcctacttcaacgactcgcagcgccaggccaccaaggatgcgggtgtgatcgcggggctcaacgtgctgc ggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggcaagggggagcgcaac gtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgacgacggcatcttcga ggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggctggtgaaccacttcg tggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtgaggcggctgcgcacc gcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatcgactccctgtttga gggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccgacctgttccgaagca ccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattcacgacctggtcctg gtcgggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaacgggcgcgacctgaa caagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccatcctgatgggggaca agtccgagaacgtgcaggacctgctgctgctggacgtggctcccctgtcgctggggctggagacggccgga ggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcagatcttcaccaccta ctccgacaaccaacccggggtgctgatccaggtgtacgagggcgagagggccatgacgaaagacaacaatc tgttggggcgcttcgagctgagcggcatccctccggcccccaggggcgtgccccagatcgaggtgaccttc gacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaaggccaacaagatcac catcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcaggaggcggagaagtaca aagcggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcctacgccttcaacatg aagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaagaaggttctggacaa gtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagagga aggagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctggg ggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggaggtggattaa

Vascular Endothelial Growth Factor (VEGF)

[0191] The VEGF gene encodes vascular endothelial growth factor (VEGF), formerly known as fms-like tyrosine kinase (Flt-1). The VEGF protein is a heparin-biding protein that induces migration and proliferation of vascular endothelial cells.

[0192] The human VEGF gene is located on chromosome 6p21. It contains 8 exons encompassing ˜16 kilobases (kb) (NCBI Accession No. NG_008732.1). The full-length wildtype VEGF protein expressed from the human VEGF gene is 412 amino acids in length.

[0193] An exemplary human wildtype VEGF protein is or includes the sequence of SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, or SEQ ID NO: 79. Non-limiting examples of nucleic acid encoding a wildtype VEGF protein are or include SEQ ID NO: 73 and SEQ ID NO: 75.

[0194] Non-limiting examples of protein and nucleotide sequences encoding a wildtype VEGF protein are shown below.

TABLE-US-00022 Human VEGF Transcript Variant 1 Protein Sequence (SEQ ID NO: 72) MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRA GEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARA SGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGG GQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITM QIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMP WSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR Human VEGF Transcript Variant 1 cDNA (SEQ ID NO: 73) ctgacqqacagacagacagacaccgccoccagocccagctaccacctcctcccoggccggcggcggacagt ggacgcggcggcgagccgogggcaggggccggagoccgcgccoggaggcggggtggagggggtcggggctc goggcgtcgcactgaaacttttcgtccaacttctgggctgttctcgcttoggaggagccgtggtccgcgcg ggggaagccgagccgagoggagccgcgagaagtqctagctogggccgggaggagccgcagccggaggaggg ggaggaggaagaagagaaggaagaggagagggggccgcagtggcgactoggcgctoggaagccgggctcat ggacgggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcccgggcc tcgggccggggaggaagagtagctcgccgaggcgccgaggagagcgggccgccccacagcccgagccggag agggagcgcgagccgcgccggccccggtcgggcctccgaaaccatgaactttctgctgtcttgggtgcatt ggagccttgccttgctgctctacctccaccatgccaagtggtcccaggctgcacccatggcagaaggagga gggcagaatcatcacgaagtggtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagac cctggtggacatcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctga tgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtccaacatcaccatg cagattatgcggatcaaacctcaccaaggccagcacataggagagatgagcttcctacagcacaacaaatg tgaatgcagaccaaagaaagatagagcaagacaagaaaaaaaatcagttcgaggaaagggaaaggggcaaa aacgaaagcgcaagaaatcccggtataagtcctggagcgtgtacgttggtgcccgctgctgtctaatgccc tggagcctccctggcccccatccctgtgggccttgctcagagcggagaaagcatttgtttgtacaagatcc gcagacgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagttaaacgaac gtacttgcagatgtgacaagccgaggcggtga Human VEGF Transcript Variant 3 Protein Sequence (SEQ ID NO: 74) MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRA GEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARA SGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGG GQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITM QIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRPCGPCSERRKHLFVQD PQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR Human VEGF Transcript Variant 3 cDNA (SEQ ID NO: 75) ctgacggacagacagacagacaccgccoccagccccagctaccacctcctcccoggccggcggcggacagt ggacgcggcggcgagccgcgggcaggggccggagcccgcgccoggaggcggggtggagggggtcggggctc goggcgtcgcactgaaacttttcgtccaacttctgggctgttctcgcttcggaggagccgtggtccgcgcg ggggaagccgagccgagoggagccgcgagaagtgctagctogggccgggaggagccgcagccggaggaggg ggaggaggaagaagagaaggaagaggagagggggccgcagtggcgactoggcgctoggaagccgggctcat ggacgggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcccgggcc togggccggggaggaagagtagctcgccgaggcgccgaggagagogggccgccccacagcccgagccggag agggagcgcgagccgcgccggcccoggtogggcctccgaaaccatgaactttctgctgtcttgggtgcatt ggagccttgccttgctgctctacctccaccatgccaagtggtoccaggctgcacccatggcagaaggagga gggcagaatcatcacgaagtggtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagac cctggtggacatcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctga tgcgatgogggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtccaacatcaccatg cagattatgoggatcaaacctcaccaaggccagcacataggagagatgagottcctacagcacaacaaatg tgaatgcagaccaaagaaagatagagcaagacaagaaaaaaaatcagttcgaggaaagggaaaggggcaaa aacgaaagcgcaagaaatcccgtocctgtgggccttgctcagagoggagaaagcatttgtttgtacaagat ccgcagacgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagttaa acgaacgtacttgcagatgtgacaagccgaggcggtga Mature Human VEGF-A (SEQ ID NO: 76) APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPT EESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVG ARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR Mature Human VEGF-B (SEQ ID NO: 77) PVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPT GQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPA DITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA Mature Human VEGF-C (SEQ ID NO: 78) AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLS KTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR Mature Human VEGF-D (SEQ ID NO: 79) FAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTS YISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRR

[0195] In some embodiments of any of the compositions described herein, the VEGF protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 72.

[0196] In some embodiments of any of the compositions described herein, the VEGF protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 74.

[0197] In some embodiments of any of the compositions described herein, the VEGF protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 76.

[0198] In some embodiments of any of the compositions described herein, the VEGF protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 77.

[0199] In some embodiments of any of the compositions described herein, the VEGF protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 78.

[0200] In some embodiments of any of the compositions described herein, the VEGF protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 79.

[0201] A non-limiting example of a human wildtype VEGF genomic DNA sequence is SEQ ID NO: 80. The exons in SEQ ID NO: 80 are: nucleotide positions 1-1104 (exon 1); nucleotide positions 4133-4184 (exon 2) and nucleotide positions 7261-7457 (exon 3); nucleotide positions 8252-8328 (exon 4); nucleotide positions 8681-8710 (exon 5); nucleotide positions 10524-10646 (exon 6); nucleotide positions 11748-11879 (exon 7); and nucleotide positions 14333-16279 (exon 8). The introns in SEQ ID NO: 80 are: nucleotide positions 1105-4132 (intron 1); nucleotide positions 4185-7260 (intron 2); nucleotide positions 7458-8251 (intron 3); nucleotide positions 8329-8680 (intron 4); nucleotide positions 8711-10523 (intron 5); nucleotide positions 10647-11747 (intron 6); and nucleotide positions 11880-14332 (intron 7).

TABLE-US-00023 Human VEGF-A Gene (NCBI Accession No.NG_008732.1) (SEQ ID NO: 80)      1 cgcctgtaat cccagcactc tgggaggcag aggtgggccg atcacttgag gtcaggagtt     61 cgagaccagc ctgggcaaca tggtgaaaca ccatctctac taaaaacaca aaaattagcc    121 aggtgtggtg gcaggcacct gcagtcccag ctactccgga ggctgaggca ggagaattgc    181 tcgaacctgg gaggcagggg ttgcagtgag ccgacatggc gccactgcac tccagtctgg    241 gcgacagagt gagaccctat ctcaaaaaaa aaaaaaaaaa aaaaagaccc aactcaagta    301 tcatctccag gaagccttcc cctactccca gcaattaaat gctcctcaga gaattcccat    361 ttttggttta ctotttggtt tacctccaga caggaagocc ccactgacac tgttgtagtc    421 ccagggtgca acacaaagca gagatcacaa gctgagttta ataattgctt gtggaataca    481 tgtcccaagc cacctcctgc aggaagccct tccagatgcc cattctagcc agtctggctc    541 tttgcttcca taccttcaca acacttgtgc ctcccccagg gcctctttct catcttgctt    601 tctggggcag ctgtgtgcac atttgtctgt gtgcagcaac tctctaaggc agggattttt    661 actcctattt ttgatgaggg gagctgtggc tcagagaggt tgaataacct aaggccacac    721 agtgagtggc agagccagga atgtgacttg ggtccatttg aatccaaagt ccctgtactt    781 tccactgccc tacctagatg tccctgtacc tcctataaaa tcagcatgga gcctggtgcc    841 tggtagtccc tacaaatatt cacaaattgg agcttagctc agctctcagg caaggcccag    901 gtcaaaaggg cagatacagc tttgggacct tagttgccac cacatgccat accttcttcc    961 cagcagaagg actccctcca agacagggta ggggtggagg atgtgaacag gggcagaaat   1021 gggcatgttt tggggtcaga cttggaggaa tagcagagat tggagtgtca gaaggtgagc   1081 atgcctgggg gtgttgggga gatgcaattc atcagggaca gcttagtgtc aggggattag   1141 actggggccc atgaaggaga ggcagaggct gatgggccta ggggtggtgt gggtaggtga   1201 gcttccccag acagtgactc tgccctgccc tctctccagc taggtcctct tccccattcc   1261 ttcccccttt cctgactgga tcctcttggg agagttaccc tccttggctt cctctgctcc   1321 aatcttttta tcagttggcc atcattactt atcattacct caagtcaaac ctccagatcc   1381 acatggggct aggacattgg cactggacca aagaggccct ttcctttgct ttctctttgt   1441 ctttttaatg cttbittgca aagacctagg cggggagaga gagagagaga gagagacaga   1501 gattgaccca cagtcagggt cagggaattg aggggaacca acccaattct ctctccttca   1561 attcaccagg tttgtatcct gcccttcctg cagatcagtg tcctgctagt cacctggggg   1621 tcaggggatg gagtgaagga caagacctcc ttccattgca gtgaagccac ttggagaaat   1681 gtgtggaaaa cagcaagacc cagtgactct ctcctcacct tctttccaat ctcaggagag   1741 attttgtccc ttcatccacc ggcttctaga ttaaccaccc acacccacac aggcgagagt   1801 ttccctgaat attggaggtg acaggacatc aggacaaagt acaactattg tgccttggcc   1861 caatcactac tttctttgtc tggggccgcc gctggctcct ggctgccttt cgcacttttc   1921 tccaccccca cccctttctc cccttccccc tcacctggaa caccttcccc ttcctccttg   1981 gctccttctg aactgccttc agagccacag actgbjggga gtggccactg cgctcccaag   2041 gtgaggccct ccaagojggg ccgagtttgc ccctcaactg ggagccagca tgacctctgt   2101 gtgggctgct ctctgcttca ctgccccttc ccccaatctg ctaggtgacc ctgggcccct   2161 ttgtgccctc tctgggcctt cggaggattc tttggggaga cagtctgctc tgacgcccct   2221 tcccctgcag caagcagcct ggggagggag gtgaggataa gtgaagtcaa gttgttcagg   2281 gggctaagcc catggaaggg aagatgccac agagatacat gtggtcttgt gattgttgtt   2341 ttgtgctttt tccccttttt tgaaagctca ggtgactagg tgacttgagc ttttaatttg   2401 gtgacaatgt gggcactggc tgagtcctta agagtacatt gttgtaaatg ccggtgacaa   2461 cacactgggg catgggatcc agagttaacc cctccaggtc acagccaggt tatatctcca   2521 caatgaaggg gggaggtggg ccatactttc tcgccctaat gaaggtagct caaaaacccc   2581 taggccaggt tgtaatccta gccttatata aaaggaattc tgtgccctca ctcccctgga   2641 tccctgggca aagccccaga gggaaacaca aacaggttgt tgtaacacac cttgctgggt   2701 accaccatgg aggacagttg gcttatgggg gtggggggtg cctggggcca cggagtgact   2761 ggtgatggct atccctcctt ggaacccctc cagcctcctc ttagcttcag atttgtttat   2821 ttgtttttta ctaagacctg ctctttcagg tctgttggct cttttagggg ctgaagaagg   2881 ccgagttgag aagggatgca agggaggggg ccagaatgag cccttagggc tcagagcctc   2941 catcctgccc caagatgtct acagcttgtg ctcctggggt gctagaggcg cacaaggagg   3001 aaagttagtg gcttcccttc catatcccgt tcatcagcct agagcatgga gcccaggtga   3061 ggaggcctgc ctgggagggg gccctgagcc aggaaataaa catttactaa ctgtacaaag   3121 accttgtccc tgctgcbggg gagcctgcca agtggtggag acaggactag tgcacgaatg   3181 atggaaaggg agggttgggg tgggtgggag ccagcccttt tcctcataag ggccttagga   3241 caccataccg atggaactgg gggtactggg gaggtaacct agcacctcca ccaaaccaca   3301 gcaacatgtg ctgaggatgg ggctgactag gtaagctccc tggagcgttt tggttaaatt   3361 gagggaaatt gctgcattcc cattctcagt ccatgcctcc acagaggcta tgccagctgt   3421 aggccagacc ctggcaagat ctgggtggat aatcagactg actggtccca ctcttcccac   3481 aggcctcaga gccccaactt tgttccctgg ggcagcctgg aaatagccag gtcagaaacc   3541 agctaggaat ttttccaagc tgcttcctat atgcaagaat gggatggggc ctttgggagc   3601 acttagggaa gatgtggaga gttggaggaa aagggggctt ggaggtaagg gaggggactg   3661 ggggaaggat aggggagaag ctgtgagcct ggagaagtag ccaagggatc ctgagggaat   3721 gggggagctg agacgaaacc cccatttcta ttcagaagat gagctatgag tctgggcttg   3781 ggctgataga agccttggcc cctggcctgg tgggagctct gggcagctgg cctacagacg   3841 ttccttagtg ctggcgggta ggtttgaatc atcacgcagg ccctggcctc cacccgcccc   3901 caccagcccc ctggcctcag ttccctggca acatctgggg ttgggggggc agcaggaaca   3961 agggcctctg tctgcccagc tgcctccccc tttgggtttt gccagactcc acagtgcata   4021 cgtgggctcc aacaggtcct cttccctccc agtcactgac taaccccgga accacacagc   4081 ttcccgttct cagctccaca aacttggtgc caaattcttc tcccctggga agcatccctg   4141 gacacttccc aaaggacccc agtcactcca gcctgttggc tgccgctcac tttgatgtct   4201 gcaggccaga tgagggctcc agatggcaca ttgtcagagg gacacactgt ggcccctgtg   4261 cccagccctg ggctctctgt acatgaagca actccagtcc caaatatgta gctgtttggg   4321 aggtcagaaa tagggggtcc aggagcaaac tccccccacc ccctttccaa agcccattcc   4381 ctctttagcc agagccgggg tgtgcagacg gcagtcacta gggggcgctc ggccaccaca   4441 gggaagctgg gtgaatggag cgagcagcgt cttcgagagt gaggacgtgt gtgtctgtgt   4501 gggtgagtga gtgtgtgcgt gtggggttga gggcgttgga gcjgggagaa ggccaggggt   4561 cactccagga ttccaataga tctgtgtgtc cctctcccca cccgtccctg tccggctctc   4621 cgccttcccc tgcccccttc aatattccta gcaaagaggg aacggctctc aggccctgtc   4681 cgcacgtaac ctcactttcc tgctccctcc tcgccaatgc cccgcgggcg cgtgtctctg   4741 gacagagttt cogggggcgg atgggtaatt ttcaggctgt gaaccttggt gggggtcgag   4801 cttccccttc attgojgcgg gctgcgggcc aggcttcact gagcgtccgc agagcccggg   4861 cccgagccgc gtgtggaagg gctgaggctc gcctgtcccc gccccccggg gcgggccggg   4921 ggcggggtcc cggcggggcg gagccatgcg cccccccctt ttttttttaa aagtcggctg   4981 gtagojggga ggatcgcgga ggcttggggc agccgggtag ctcggaggtc gtggcgctgg   5041 gggctagcac cagcgctctg tcgggaggcg cagcggttag gtggaccggt cagcggactc   5101 accggccagg gcgctoggtg ctggaatttg atattcattg atccgggttt tatccctctt   5161 cttttttctt aaacattttt ttttaaaact gtattgtttc tcgttttaat ttatttttgc   5221 ttgccattcc ccacttgaat cgggccgacg gcttggggag attgctctac ttccccaaat   5281 cactgtggat tttggaaacc agcagaaaga ggaaagaggt agcaagagct ccagagagaa   5341 gtcgaggaag agagagacgg ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga   5401 caggggcaaa gtgagtgacc tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc   5461 ccccttggga tcccgcagct gaccagtcgc gctgacggac agacagacag acaccgcccc   5521 cagccccagc taccacctcc tcccojgccg gcggcggaca gtggacgcgg cggcgagccg   5581 cgggcagggg ccggagcccg cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt   5641 cgcactgaaa cttttcgtcc aacttctggg ctgttctcgc ttcggaggag ccgtggtccg   5701 cgcgggggaa gccgagccga gcggagccgc gagaagtgct agctcgggcc gggaggagcc   5761 gcagccggag gagggggagg aggaagaaga gaaggaagag gagagggggc cgcagtggcg   5821 actojgcgct cggaagccgg gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc   5881 tccagccgcg cgcgctcccc aggccctggc cojggcctcg ggccggggag gaagagtagc   5941 tcgccgaggc gccgaggaga gojggccgcc ccacagcccg agccggagag ggagcgcgag   6001 ccgcgccggc ccoggtojgg cctccgaaac catgaacttt ctgctgtctt gggtgcattg   6061 gagccttgcc ttgctgctct acctccacca tgccaaggta agoggtcgtg ccctgctggc   6121 gccgcgggcc gctgcgagcg cctctccogg ctggggacgt gcgtgcgagc gcgcgcgtgg   6181 gggctccgtg ccccacgcgg gtccatgggc accaggcgtg cggcgtcccc ctctgtcgtc   6241 ttaggtgcag ggggaggggg cgcgcgcgct aggtgggagg gtacccggag agaggctcac   6301 cgcccacgcg ggccctgccc acccaccgga gtcaccgcac gtacgatctg ggccgaccag   6361 ccgagggcgg gagccggagg aggaggccga gggggcbggg cttgcgttgc cgctgccggc   6421 tgaagtttgc tccojgccgc tggtccogga cgaactggaa gtctgagcag cgggggcggg   6481 agccagagac cagtgggcag ggggtgctcg gaccttggac cgcgggaggg cagagagcgt   6541 ggagggggca gggcgcagga gggagagggg gcttgctgtc actgccactc ggtctcttca   6601 gccctcgccg cgagtttggg aaaagttttg gggtggattg ctgoggggac cccccctccc   6661 tgctgggcca cctgcgccgc gccaaccccg ccoitccccg ctcgcgtccc gctcggtgcc   6721 cgccctcccc cgccojgccg ggtgcgcgcg gcgcggagcc gattacatca gcccgggcct   6781 ggccggccgc gtgttcccgg agcctcggct gcccgaatgg ggagcccaga gtggcgagcg   6841 gcacccctcc ccccgccagc cctccgcggg aaggtgacct ctcgaggtag ccccagcccg   6901 gggatccaga gaaccatccc taccccttcc tactgtctcc agaccctacc tctgcccagt   6961 gctaggagga atttcctgac gccccttctc ttcacccatt tcctttttag cctggagaga   7021 agcccctgtc accccgctta ttttcatttc tctctgcgga gaagatccat ctaacccctt   7081 tctggcccca gagtccaggg aaaggatgat cactgtcaga agtcgtggcg cgggagccca   7141 ctgggcgctt tgtcacattc caccgaaagt cccgacttgg tgacagtgtg cttcccttcc   7201 ctcgccaaca gttccgagtg agcbitgott tagctotcgt gggggtgggt caagggagga   7261 tttgaagagt cattgcccca ctttaccctt ttggagaaat ggcttgaaat ttgctgtgac   7321 acgggcagca tgggaatagt ccttcctgaa ccctggaaag gagctcctgc cagccttgca   7381 cacactttgt cctggtgaaa ggcagccctg gagcaggtgt ttttttggaa ctccaaacct   7441 gcccacccaa cttgcttctg aaagggactc taaagggtcc ctttccgctc ctctctgacg   7501 ccttccctca gccagaattc ccttggagag gaggcaagag gaaagccatg gacaggggtc   7561 gctgctaaca ccgcaagttc ctcagaccct ggcacaaagg ccttggctac aggcctccaa   7621 gtagggagga gggggaggag tggctgcctg gccacagtgt gaccttcaga ggcccccaga   7681 gaaggacacc tggcccctgc ctgcctagaa ccgcccctcc tgtgctccct ggccttggaa   7741 ggggtatgaa atttccgtcc cctttcctcc ttggggccca ggaggagtgg agggtcccgg   7801 gagaatattg tcagggggaa ggcagggggt gtcatgggaa tgggtgaggg ggctgaggtg   7861 cagaatccag ggggtccctg caggagccgc agtggtaagc tgtccagctg gaagcctggt   7921 aactgtbitt ttctcttgag aggggcttcc tgtgaccttg gctgtctctg ggagcagggc   7981 tggggtacct gagtggggtg catttggggt gtttgggaag gagagggaaa gaaagatgga   8041 cagtgggact ctcccctagc agggtctggt gttccgtagg ctagagtgcc cctctgctct   8101 gcgagtgctg ggcgggaggg gagttggtga gagctggaga cccccaggaa gggctggcag   8161 aagcctttcc ttttgggtgc bitcaggtcc gcatgtcttg gcttgttgac cttcacagct   8221 tctggcgagg ggaggaatga tctgatgcgg gtggggaggg ttagaggagg cctcaggcct   8281 aaggtggtgc agggggcccc ctaggggctg ggcagtgcca aggcataaaa gccttccctg   8341 gtccctggtg gcatttgaag gtgcccaggt gagaggggct tggcacctcc tcaccctggg   8401 agggagaaga aaccagggaa caggtaggag tgggagacag gtgaggcttt ggaaatctat   8461 tgaggctctg gagagatttg tgtagagagg aaaatgtggt tctcccccag ggtctcctcc   8521 tgggttttta ccctctaagc aacctgtggg catgcbjggt tattcctaag gactagaaga   8581 gcttggatgg gggagggtgg ttggtgccct toggtcctcg gcacccccct ccgtctccaa   8641 caccagctca ccctggtatt tttcatgtca gcaggagaag gtcaccatgt tgtttttctc   8701 gcccctagtc cttccttcct gccccagtcc aaatttgtcc tcctatttga ccttaatact   8761 taccatggct ttggaccagg gaactagggg gatagtgaga gcagggagag ggaagtgtgg   8821 ggaaggtaca ggggacctcg acagtgaagc attctggggt tttcctcctg catttcgagc   8881 tccccagccc ccaacatctg gttagtcttt aacttcctcg ggttcataac catagcagtc   8941 caggagtggt gggcatattc tttgcccgtg gggacccccg gttgtgtcct gttcgactca   9001 gaagacttgg agaagccaga ggctgttggt gggagggaag tgaggaggga ggaggggctg   9061 ggtggcbggg cctgtgcacc ccagcccctg cccatgccca tgccttgctc tctttctgtc   9121 ctcagtggtc ccaggctgca cccatggcag aaggaggagg gcagaatcat cacgaaggtg   9181 agtccccctg gcbgttggat ggggttccct gtcctctcag gggatgggtg gatggcctaa   9241 ttcctttttc ttcagaactg tggggaggaa ggggaagggg cacaggaata taaggatcaa   9301 gaaagaaaga gcbjggcacc acgaggttca ccctcagttt cgtgaggact ctccgctgtt   9361 caggtctctg ctagaagtag gacttgttgc ctttttcttc tgctctttcc agtaaaattt   9421 tatttggaga aggagtcgtg cgcacagagc aggaagacag tgttcaggga tcctaggtgt   9481 tgggggaagt gtcccttgtt tcccotagct cccaggggag agtggacatt tagtgtcatt   9541 tcctatatag acatgtccca tttgtgggaa ctgtgaccct tcctgtgtga gctggaggca   9601 cagagggctc agcctaatgg gatctctcct cccttccctg gtttgcattc ctttgggggt   9661 ggagaaaacc ccatttgact atgttcgggt gctgtgaact tccctcccag gccagcagag   9721 ggctggctgt agctcccagg cgccccgccc ccctgcccaa ccccgagtcc gcctgccttt   9781 bittccgttg tggtttggat cctcccattt ctctggggac accctggctc tccccaccac   9841 tgactgtggc ctgtgctctc cacctctggg gagggaaggc cctggggtct tccttcccgc   9901 gagtttccct gacctaaatc tggcgtggct gggtagtggc cagcagtggt gatgcccagc   9961 ctgttctgcc tcctccttcc ccaccccagg agccctttcc ttggcctagg acctggcttc  10021 tcagccactg accggccccc tgcttccagt gcgccactta ccccttccag cttcccagtg  10081 gtctctggtc tgggagaggc aggacaaagg tctttgtttg ctggagaaaa ggttgtctgc  10141 gataaataag gaaaaccacg aaagcctggt bittggagtg tacgtgtgtg ctcccccagg  10201 cagtggaggc cagccctcct tggaggggcg gctgcctgat gaaggatgcg ggtgaggttc  10261 cccgcctcca cctcccatgg gacttgggga ttcattccaa ggggaagctt tttgggggaa  10321 ttcctacccc aggtcttttt accctcagtt accaacccct tgcccaggcc agaccttcct  10381 gctatcccct cctgggccac aagcctggcc ctcctctgtc ccaattgtga tgaaggggca  10441 gttcaaaact tcttgattag tcatcttctc ccctatcgac ttggctttaa aaaatgacct  10501 tttcagactt ctagtctcgt tcactctttt tgatgatgct ttgccgtaac ccttcgtggg  10561 tagagaagga ttctgtgccc attggtggtc tggataaaag aaatagagac ctcacaggaa  10621 gcagtggact ggcctgtttc cccactgttc tttctgtttt cacacctgtg gccttctccc  10681 caccttcttc ccaatcaacc tattgtgtac atagcccccc tcattgtcct ttattcttct  10741 ggaaagcaga ccttggaggg aggagtgagg gggaggctca gcbgtggtct ctggggggtg  10801 ggggttggga gcbggggtgg aagtccacga agcatacact taagatgctt tggtgaagtt  10861 ctaaacttca tattacccag gctgaaaaaa gagcacttgt tcctagggct ggaaatggaa  10921 gccaaaacac cacctttttc agcctgtttc agcatcttta gagatcagcc caacccactt  10981 acacagttga gcagagttgg aggcctagag aggggaggga ctggcccaag gtcataccaa  11041 ctcatggcca gagcctgggc ctcctcactg gccaggtgtt atttcttccc tctgggtagg  11101 gaacctattt cagggacagg attgctatgt ggtagtggtg gtggggtgcg ataggcgtgg  11161 caggcbjggc cacaatttgg agtagtcatg ccagagtcct gcatttattt attctcaagg  11221 gccccgcctc tgtggcccag aattacccct tcatgctcca gtgcacccca ggcttcgtgg  11281 ccagcctggg aaactgtctc taccctggtc tcccttcaga tcagcttcta gaaatgtttc  11341 gtggctacag tggcagcact gttttttcca tgatgcaagc agtttgccct cttgggcggg  11401 gttatcagtg gctggcaggg ctggcacagc gtgtccgccc actgccacct gtgggttcca  11461 ggagggccca gcccctgtgc tgatgcccac caccttctca gctcatgtct ggggaagagg  11521 actggcaggg ggaaaggtgc ctcctcctga aaggtgcctc ctctgttttt gcctaatata  11581 ggcttgggaa cactttgatg tcagctaatt ctgactcctt tacttactag ctgtgcggcc  11641 ttggggcaac ttacttagcc tctttgagcc tcctgttccc catctgtaaa atggaatctc  11701 aatagtgtct aatagtacca tgtggagaaa cttgtgtgaa atgatagctg tggactactg  11761 tacacagtac tcaggatgta gtaagtgctc aataaacagc bittggtatg gttgacgtta  11821 tggtagtggt tgtggggagg acgtaggaaa ctggagacta gcttggcaaa gctggctctt  11881 cctcctttta gggaaagctt agagcatccc catggggtat acccatactc agactgtcct  11941 ctggcatcga ggttggccca ggattcagtt cagcbgtcac agtgaggtgg cgggatcaga  12001 tgtggcaggc catgtccctt ggaacttgag tacatcgtgt gatctctgga atgaaaacag  12061 gccttcacca gtgttgatgg tggaaagctt agggaagtgc ttcaaacaca gtaggaggga  12121 cttacgttag attttggaag gacttgcctg attcggaagc tccaaagagt ggcattacag  12181 agcbjggtgg agagaggggc tagccatctt ttgtgtcgcc caccgggctc atgtgtcatc  12241 gcctctcatg cagtggtgaa gttcatggat gtctatcagc gcagctactg ccatccaatc  12301 gagaccctgg tggacatctt ccaggagtac cctgatgaga tcgagtacat cttcaagcca  12361 tcctgtgtgc ccctgatgcg atgojggggc tgctgcaatg acgagggcct ggagtgtgtg  12421 cccactgagg agtccaacat caccatgcag gtgggcatct ttgggaagtg gggcaagggg  12481 gggataggga ggggggtaac actttgggaa caggtggtcc caggtcgttt cctggctaga  12541 tttgccttgt ctggctcctg cccctgagtt gcacagggga ggtatggtgg ggtcttgcct  12601 tctgtggaga agatgcttca ttcccagccc aggttcccag caagccccaa ccatctcctt  12661 ctccctgatg gttgcccatg ggctcaggag gggacagatg gatgcctgtg tcaggagccc  12721 ctctctccct ctcttggaga gagtcctgag tgccccccct tcttgggggc tttgtttggg  12781 aagctggatg agcctggtcc atggagagtt taaaaagtct tttggtgtta cctggtaatg  12841 gggcacatct cagcccagat agggtgggag ggagctgtga aacacaggga gggggttgct  12901 ttcgggtatc tactaggagt cagggtgaag cctagagagg atgaaagaag gggaggggat  12961 ggggagtggt aagaacctag gatttgaatt cccagcctgg ccaacccttg cagccatgtc  13021 ttggcctcaa gtggaacaag ggctccttga ggccagcagg gttgggggag ttggggtggg  13081 cctgagcctc tttcctgcta gagctcttgg tcctccctgc ctccaccacc catccctgct  13141 ctgcagaacc cctgggtgct gagtggcagg agccccaggg ttgtcccatc tgggtatggc  13201 tggcbgggtc actaacctct gtgatctgct tccttccttt ccagattatg cggatcaaac  13261 ctcaccaagg ccagcacata ggagagatga gcttcctaca gcacaacaaa tgtgaatgca  13321 ggtgaggatg tagtcacgga ttcattatca gcaagtggct gcagggtgcc tgatctgtgc  13381 cagggttaag catgctgtac tttttggccc ccgtccagct tcccgctatg tgacctttgg  13441 cattttactt caatgtgcct cagtttctac atctgtaaaa tgggcacaat agtagtatac  13501 ttcatagcat tgttataatg attaaacaag ttatatatga aaagattaaa acagtgttgc  13561 tccataataa atgcbgtttt tactgtgatt attattgttg ttatccctat cattatcatc  13621 accatcttaa cccttccctg ttttgctctt ttctctctcc ctacccattg cagaccaaag  13681 aaagatagag caagacaaga aaagtaagtg gccctgactt tagcacttct ccctctccat  13741 ggccggttgt cttggtttgg ggctcttggc tacctctgtt gggggctccc atagcctccc  13801 tgggtcaggg acttggtctt gtgggggact tgtggtggca gcaacaatgg gatggagcca  13861 actccaggat gatggctcta gggctagtga gaaaacatag ccaggagcct ggcacttcct  13921 ttggaaggga caatgccttc tgggtctcca gatcattcct gaccaggact tgctgtttcg  13981 gtgtgtcagg gggcactgtg gacactggct cactggcttg ctctaggaca cccacagtgg  14041 ggagagggag tgggtggcag agaggccagc ttttgtgtgt cagaggaaat ggcctctttt  14101 ggtggctgct gtgacggtgc agttggatgc gaggccggct ggagggtggt ttctcagtgc  14161 atgccctcct gtaggcggca ggcggcagac acacagccct cttggccagg gagaaaaagt  14221 tgaatgttgg tcattttcag aggcttgtga gtgctccgtg ttaaggggca ggtaggatgg  14281 ggtgggggac aaggtctggc ggcagtaacc cttcaagaca gggtgggcgg ctggcatcag  14341 caagagcttg cagggaaaga gagactgaga gagagcacct gtgccctgcc ctttccccca  14401 caccatcttg tctgcctcca gtgcbgtgcg gacattgaag cccccaccag gcctcaaccc  14461 cttgcctctt ccctcagctc ccagcttcca gagcgagggg atgcggaaac cttccttcca  14521 ccctttggtg ctttctccta agggggacag acttgccctc tctggtccct tctccccctc  14581 ctttcttccc tgtgacagac atcctgaggt gtgttctctt gggcttggca ggcatggaga  14641 gctctggttc tcttgaaggg gacaggctac agcctgcccc ccttcctgtt tccccaaatg  14701 actgctctgc catggggaga gtagggggct cgcctgggct cggaagagtg tctggtgaga  14761 tggtgtagca ggctttgaca ggcbjgggag agaactccct gccaagtacc gcccaagcct  14821 ctcctcccca gacctcctta actcccaccc catcctgctg cctgcccagg gctccaggac  14881 acccagccct gcctcccagt ccaggtcgtg ctgagcaggc tggtgttgct cttggttccg  14941 tgccagctcc caaggtagcc gcttccccca caccgggatt cccagaggtt ctgtcgcagt  15001 tgcaaatgaa ggcacaaggc ctgatacaca gccctccctc ccactcctgc tccccatcca  15061 ggcaggtctc tgaccttctc cccaaagtct ggcctacctt ttatcacccc cggaccttca  15121 gggtcagact tggacagggc tgctgggcaa agagccttcc ctcaggcttt gccccctgcc  15181 ggggactggg agccactgtg agtgtggaga cctttgggtc ctgtgccctc cacccagtct  15241 cggcttccca ccaaagcctt gtcaggggct gggtttgcca tcccatggtg ggcagcgtga  15301 ggagaagaaa gagccatcga gtgcttgctg cccagacacg cctgtgtgcg cccgcgcatg  15361 cctccccaga gaccacctgc ctcctgacac ttcctccggg aagojgccct gtgtggcttt  15421 gctttggtog ttcccccatc cctgcccacc ttaccacttc ttttactccc cccaccgccc  15481 ccgctctctc tctgtctctg tttttttatt ttccagaaaa tcagttcgag gaaagggaaa  15541 ggggcaaaaa cgaaagcgca agaaatcccg gtataagtcc tggagcgtgt acgttggtgc  15601 ccgctgctgt ctaatgccct ggagcctccc tggcccccag tacaacctcc gcctgccatt  15661 ccctgtaacc ctgcctccct cccctggtcc ttccctggct ctcatcctcc tggcccgtgt  15721 ctctctctca ctctctcact ccactaattg gcaccaacgg gtagatttgg tggtggcatt  15781 gctggtccag ggttggggtg aatgggggtg ccgacttggc ctggaggatt aagggagggg  15841 accctggctt ggcbjggcac cgattttctc tcacccactg ggcactggtg gcgggcccat  15901 gttggcacag gtgcctgctc acccaactgg tttccattgc tctaggcttc tgcactcgtc  15961 tggaagctga gggtggtggg gagggcagac atggcccaag aagggcbgtg aatgactgga  16021 ggcagcttgc tgaatgactc cttggctgaa ggaggagctt gggtgggatc agacaccatg  16081 tggcggcctc ccttcatctg gtggaagtgc cctggctcct cacggaggtg gggcctctgg  16141 aggggagccc cctattccgg cccaacccat ggcacccaca gaggcctcct tgcagggcag  16201 cctcttcctc tgggtoggag gcbgtggtgg gccctgccct gggccctctg gccaccagcg  16261 gcctggcctg gggacaccgc ctccgggctt agcctcccat cacaccctac tttagcccac  16321 cttggtggaa gggcctggac atgagccttg cacggggaga aggtggcccc tgattgccat  16381 ccccagcagg tgaagagtca aggcgtgctc cgatgggggc aacagcagtt gggtccctgt  16441 ggcctgagac tcacccttgt ctcccagaga cacagcattg ccccttatgg cagcctctcc  16501 ctgcactctc tgcccgtctg tgcccgcctc ttcctgojgc aggtgtccta gccagtgctg  16561 cctctttccg ccgctctctc tgtcttttgc tgtagcgctc ggatccttcc agggcctggg  16621 ggctgaccgg ctgggtgggg gtgcagctgc ggacatgtta gggggtgttg catggtgatt  16681 ttttttctct ctctctgctg atgctctagc ttagatgtct ttccttttgc ctttttgcag  16741 tccctgtggg ccttgctcag agcggagaaa gcatttgttt gtacaagatc cgcagacgtg  16801 taaatgttcc tgcaaaaaca cagactcgcg ttgcaaggcg aggcagcttg agttaaacga  16861 acgtacttgc aggttggttc ccagagggca agcaagtcag agaggggcat cacacagaga  16921 tggggagaga gagagagaaa gagagtgagc gagcgagcga gojggagagc gcctgagagg  16981 ggccagctgc ttgctcagtt tctagctgcc tgcctggtga ctgctgcctt ctctgctttt  17041 aaggcccctg tggtgggctg caggcactgg tccagcctgg cggggcctgt tccgaggttg  17101 ccctggttgc ctgagtggta ggcbggtgtg gcttagtgta gtggtgtgga cgcaagctgt  17161 gtgttgtgtc ctgtggtcct tctgctcata gtggctgttg gtcctgatgt tattactacc  17221 tctggtagta atgctgagaa gctgaaagcc gattccaggt gtggacaatg tcaacaaagc  17281 acagatgctc tcgctggggc cttgcctcgg ccctttgaag tctgcatggc tgggcttctc  17341 actcactcag tgtttcttgc tgggggaagg aattgagtct cccacttcag actgggcctc  17401 cctgaggaaa gggttgtgtc tccccactca gactgaggtt ccctgagggt agggctgtgt  17461 ctctcccctc cgacctgggc tccctgatag ggctgtctcc ccgctcagac tgaggctccc  17521 tcaggccagg gctatgtctc cctcctcaga ctggggctct gagggcaagg ggtctggctg  17581 ttcgtttagg atggggcact tttgcctaca cactgaagga gctgtagcat ccaagaatac  17641 tagatacctt taatcctcca ccagtcatgg tgacaacccc aagcagccca cacattttca  17701 agtgccccca ggatgcgtgg agggaggggt ctgtgcccat tctcctgaca ttagcctgtg  17761 agctccgtaa gccojggcct cgtttacgta cctttgtgag cccojggcat ctgtacctct  17821 ttcctttgcc catactgggg accaaggaag tgtcaagtgc atgagtgaat gtgtgactca  17881 gttcagaggg tgaggtcagg agcacagggt cgggacaggt ggctggcatc ttttaatgcc  17941 ttagcttatg ttctttatac caacttggcc tgtgctcaga gtgagggagg ccctgggggt  18001 cagggtaagc gtcagtcagg gaggcaagac tttgtgggga tttcctagac agggccaagg  18061 cacccccagc tcaccccgag gcbgtgttag ggaagtcctt ggagtgtctc ccctccccca  18121 gcaatgttct tgtggcttgt gtgtgctcag gggatgctgg gaaccaggcc tgggtagttg  18181 gtgtggggtg ctgtctgtct tggccctatg tgaaaccaag agggcgtata ttagtgctgg  18241 ggtgggggct ctgcctaact tcagggctgg atgaggggag tctcagttcc ccaggggtcc  18301 ttgggaaaga taagggactt gacattttag ggtttttagg tgattattct gctgatgggg  18361 gtttgtgtga agtgacctgg gagctaactg aagttactct aacctcccaa tacctttacc  18421 caacccccaa gctggctgta tctgggaata tcagtttcca aaattggagg cttaggactc  18481 cgtttogggg ctccccagaa gggtagggcc tgttctgcct ccttctcaca atcacccagg  18541 ggcaggggca tgctgagaaa gttcttggag gccccctttg cttcagctgg agtagtgaag  18601 ccgccgaatt gtotctoccc atcctaagtg aagcagcata tttgaaagga aagacaacct  18661 gttacctggg cctgcaacct ccaggcagct caagagagat gaggcctaca gccacagtgg  18721 gaggggacat ggggaatgga gatggtccct caccttcctg gggcctcctg ctctacgcta  18781 ccccctojgg agcctcctgt ccccagggca ggcccttgcc attgttggtc acccggccaa  18841 gcctctctgc ctcaggcgtt ctcccagaag atctgcccac tctcttcccc acaccagccc  18901 ctagagactg aactgaaaac cctcctcagc agggagcctc ttctgattaa cttcatccag  18961 ctctggtcac ccatcagctc ttaaaatgtc aagtggggac tgttctttgg tatccgttca  19021 tttgttgctt tgtaaagtgt tcccatgtcc ttgtcttgtc tcaagtagat tgcaagctca  19081 ggagggtaga ctgggagccc ctgagtggag ctgctgctca ggccggggct ccctgagggc  19141 agggctgggg ctgttctcat actggggctt tctgccccag gaccacacct tcctgtcctc  19201 tctgctctta tggtgccgga ggctgcagtg acccaggggc ccccaggaat ggggaggccg  19261 cctgcctcat cgccaggcct cctcacttgg ccctaacccc agcctttgtt ttccatttcc  19321 ctcagatgtg acaagccgag goggtgagcc gggcaggagg aaggagcctc cctcagggtt  19381 tojggaacca gatctctcac caggaaagac tgatacagaa cgatcgatac agaaaccacg  19441 ctgccgccac cacaccatca ccatcgacag aacagtcctt aatccagaaa cctgaaatga  19501 aggaagagga gactctgcgc agagcacttt gggtccggag ggcgagactc cggcggaagc  19561 attccojggc gggtgaccca gcacggtccc tcttggaatt ggattcgcca ttttattttt  19621 cttgctgcta aatcaccgag cccggaagat tagagagttt tatttctggg attcctgtag  19681 acacacccac ccacatacat acatttatat atatatatat tatatatata taaaaataaa  19741 tatctctatt ttatatatat aaaatatata tattcttttt ttaaattaac agtgctaatg  19801 ttattggtgt cttcactgga tgtatttgac tgcbgtggac ttgagttggg aggggaatgt  19861 tcccactcag atcctgacag ggaagaggag gagatgagag actctggcat gatctttttt  19921 ttgtcccact tggtggggcc agggtcctct cccctgccca ggaatgtgca aggccagggc  19981 atgggggcaa atatgaccca gttttgggaa caccgacaaa cccagccctg gcgctgagcc  20041 tctctacccc aggtcagacg gacagaaaga cagatcacag gtacagggat gaggacaccg  20101 gctctgacca ggagtttggg gagcttcagg acattgctgt gctttgggga ttccctccac  20161 atgctgcacg cgcatctcgc ccccaggggc actgcctgga agattcagga gcctgggcgg  20221 ccttcgctta ctctcacctg cttctgagtt gcccaggaga ccactggcag atgtcccggc  20281 gaagagaaga gacacattgt tggaagaagc agcccatgac agctcccctt cctgggactc  20341 gccctcatcc tcttcctgct ccccttcctg gggtgcagcc taaaaggacc tatgtcctca  20401 caccattgaa accactagtt ctgtcccccc aggagacctg gttgtgtgtg tgtgagtggt  20461 tgaccttcct ccatcccctg gtccttccct tcccttcccg aggcacagag agacagggca  20521 ggatccacgt gcccattgtg gaggcagaga aaagagaaag tgttttatat acggtactta  20581 tttaatatcc ctttttaatt agaaattaaa acagttaatt taattaaaga gtagggtttt  20641 ttttcagtat tcttggttaa tatttaattt caactattta tgagatgtat cttttgctct  20701 ctcttgctct cttatttgta coggtttttg tatataaaat tcatgtttcc aatctctctc  20761 tccctgatcg gtgacagtca ctagcttatc ttgaacagat atttaatttt gctaacactc  20821 agctctgccc tccccgatcc cctggctccc cagcacacat tcctttgaaa taaggtttca  20881 atatacatct acatactata tatatatttg gcaacttgta tttgbitgta tatatatata  20941 tatatgttta tgtatatatg tgattctgat aaaatagaca ttgctattct gttttttata  21001 tgtaaaaaca aaacaagaaa aaatagagaa ttctacatac taaatctctc tcctttttta  21061 attttaatat ttgttatcat ttatttattg gtgctactgt ttatccgtaa taattgtggg  21121 gaaaagatat taacatcacg tctttgtctc tagtgcagtt tttcgagata ttccgtagta  21181 catatttatt tttaaacaac gacaaagaaa tacagatata tcttaaaaaa aaaaaagcat  21241 tttgtattaa agaatttaat tctgatctca aagctcctct tggtttctcc ttctccattg  21301 aatccttgct ctagacttcc tcccgccccc tttccctctt cctctgggga acatggcatt  21361 tgtcttgggt ctgggaaagg tacgtctaat gtgtaggata tggggtgacc caccttgttg  21421 tgcbgggggc aaagtccttc cattttggct gagctggtcc tgggggaacc catccatcct  21481 gtcttgatat agaaggtggg aagctctggg aatgggtgga gggggagaaa cagcttagga  21541 gccaagggcc cttgcaattg gtagtgctgc cttcaggaat tagatgatcc aggcccctgt  21601 cccttagcca gggaaagaac tggccatgtc tccaagcttg ctgcccagga gacaggagag  21661 agcbgttttt gtctgtgggg gtcttgttgg ctgcaacagg ctgggagtgg gagggggatg  21721 ctgctggagg gctgtgactc cagggtgtaa cttaatttta catagtttta caccctggag  21781 ttccttgagc ctctggaaga tggacccata ggtttggtca ccactgatgg gacactccct  21841 gccccagctt gccataagct cttctctcac gtcctgctcc tgggtaaggt ggcacctatc  21901 caggtctttg acactgaagg gcagtgcttc caaattcact tcctctagcc tctcatttat  21961 tcttgcaaac catagatatg gcttgaataa atattgagcc agtcattgtg ctgctatgaa  22021 taagacacaa ttccacccct caaggatctg gtgaggatgg gtgggtgggg agacccaaaa  22081 ctataaatcc atgagcagaa aaatacataa aatgtgctgg gggcatctga tctagcttgg  22141 gagtgggagt tgtattgggg gtggtggctg gggggtggtg tcttatgaca ttatctctag  22201 gctgccactt aaagtatggt ttgaagacag ggagaacggg gojgcggagt gaaagggttg  22261 aggacatccc aggcagaagg gatagtgtga gcaaggcatg aaggtggcac ttgggcaggg  22321 gcagggagtg ggtgggcagg gtggaggctg gagacacggg caagggttag ctccaaggga  22381 gcctgcagca ccatgccaag agcctagggc ctgtcaggga tgagcagcag ccgaggggtt  22441 ttaaacactg agojgctcag tcagatagac ttttccatag gtgcctggca acagtatggg  22501 aggcagagag gccggtagag gctgttgtgg tcttccagga ggaattgtgc tggtggtggg  22561 gaagcacctt tggtgactgg cagtgccggc cattgcaagg tctcagcctc aggcagcttt  22621 tggtctagta agtgctcctt tcccaatcac tgaccacgtg ccgaccccta cattggttaa  22681 cactgaatct gcacagcagc cctgggaggt aggtgctttt tttttttttt tttttttttt  22741 gagatggagt cttgctctgt cacccaggct ggagtacaat ggtgcgatct cgggtcactg  22801 caacctccgc ctcccaggtt caagggattc tccctcctca gcctcccgag tagctgggat  22861 tacaggcacg caccatcatg cccgactaat tttbitgttt tcgtagagac ggggtttcac  22921 catgttggcc aggctggcct caaacccttg acctcaggtg atctgcccgc cttggcctcc  22981 caaagtgctg gcattacaga tgtgagccac cgcgccojgc aggtaggggc ttttttcatc  23041 ccatctggat ttttgctgga gcctttaaat tggccgcctg gcttctcctc tggccttcct  23101 ttagttgaat ctcacacaac tgccagagtg agcctgttaa aatgtgagtt aagttttggc  23161 accttttgac tcaaaacctt ccagagatag ttttactcgg agaaaaaccc aaatggcctt  23221 aaaaggcctg caccatttgg gctgcctccc tgactactca atgacttcgg gc Human VEGF-B Gene (NCBI Accession No. NG_029823.1) (SEQ ID NO: 81)      1 gccgtcccog ccgccgctgc ccgccgccac cggccgcccg cccgccoggc tcctccggcc     61 gcctccgctg cgctgcgctg cgctgcctgc acccagggct cgggaggggg ccgcggagga    121 gtcgcccccc gcgccojgcc cccgcccgcc gcgccojggc ccgcgccatg gggctctggc    181 tgtcgccgcc ccccgcgccg cojggctagg gcgatgojgg cgccccojgc gggcggcccc    241 ggcgggcacc atgagccctc tgctccgccg cctgctgctc gccgcactcc tgcagctggc    301 ccccgcccag gtacgtgcgg cccgacagcg cgcccgcccg cccgccgtgc cctctctcaa    361 ggttggcgga agtgaggagg cgacccgcgg cctojgccga ggggatctgc ggggtccggc    421 cttggacgcg ggcgtctojg gggccoggcg cgtgcatccc ctgggaggtg cccctccccg    481 ctggcccgcc agccccagtc tggggccact cctccgcccc accccgtccc ctgggcaccg    541 cogggggcgg ggctccctcg gtgcctgcag gacctgcttc ggtgggcact gtgcgcgctc    601 ctgatctgca tgcagccccc aaacatgctc ggctccgcgg cctggagatt tggcgcggcc    661 accagagcac ctgttgcgtt ttgggccagg gcaggtcccg ggtggccagg agaggacagg    721 taaagctaga gcagtggccg caggaacaga gcaatctgga aagatgtcag agaggtggtg    781 aagcctactg atgcaagggc aaagccccag ggacggtgac agggccacac cctcctaaag    841 tgtaccttgg gtacaggtct tttctctccc acaggcccct gtctcccagc ctgatgcccc    901 tggccaccag aggaaaggta atacttacaa aaactojgca ctagccagca ctaagagggt    961 ttgtcatggg ccctgattcc aggtgtccat catcttgtgt aactccccta gaagattcaa   1021 actattattc tacccatttc acagaggagg aaattgaggc agtgggttta ctgggatctg   1081 gataaacagg gcaggggaag acaggttgtg agggcagagt ggggagggct agtggagggt   1141 ggctgtgact tggggactgg ggaggacaga tgctgggagc agctgcagga aaaccagtga   1201 ggacttaacc cctaccggtc tgctcccagt ggtgtcatgg atagatgtgt atactcgcgc   1261 tacctgccag cccojggagg tggtggtgcc cttgactgtg gagctcatgg gcaccgtggc   1321 caaacagctg gtgcccagct gcgtgactgt gcagcgctgt ggtggctgct gccctgacga   1381 tggcctggag tgbitgccca ctgggcagca ccaagtccgg atgcaggtac tgggcaggtg   1441 gggcaacggg caggggatgc aggtactggg caggtggggc agojggcagg gtggatgctg   1501 gctggctctg gggcbggggc agcctggaga ctgatgcaca ggagacaggg ttggggggag   1561 ggcbggtggc cagcctcccg gctgttgggt gagcttttct cccttcagtc ttagagcatc   1621 ccctttctct ctctccctca ctgtcccccc tgttcttctc ctgagcacag atcctcatga   1681 tccggtaccc gagcagtcag ctgggggaga tgtccctgga agaacacagc cagtgtgaat   1741 gcaggtgcca gccaggccca acttctgagc tcgcagaggc caggcttggg gggtgctggg   1801 tatggtggtc cacagaactg gggaccaggt tcctaagagt agaaccaagg ggccgggcgt   1861 ggtagctcac gcctgtaatc ccagcacttt gggaggccga ggcgggcgga tcatgaggtc   1921 aggagatcga gaccatcctg gctaacatgg taaaaacctg tctctactaa aaaaatacaa   1981 aaaattagcc gggcgtggtg gojggcacct gtagtcccag ctactccgga ggctgaggca   2041 ggagaatggc atgaacctgg gaggcgtagc ttgcagtgag ccaagatcgt gccactgcat   2101 tccagcctgg gcgacagagc aagactctgc cacaaaaaaa aaaaaaaaaa aaaaaaaaaa   2161 agagtagagc caagggtagg ccttggatct ggggcaacaa agtaggatgc ttgggccggg   2221 ggtagtggct cacacctata atcccagcac tttgggaggc ccaggcaggc agatcacctg   2281 aggtaaggcg tttgagacca gcctggccaa catggtgaaa ccccatctct actaaaaaaa   2341 aatacaaaaa ttagccgcgc atggtggcag gtgcctgtaa tcccagctac ttgggaggct   2401 gagacaagag aatagcttga acctgggagg cggaggttgc agtgagccga gaccacgcca   2461 ctgcactcca gcctgggcaa gaagagggaa acacagtctc aaagagagag agagagagag   2521 agagagagag agagagagag taggatgctg ggatttcctg atcttcctct tgtttgtctg   2581 tgtctgtcta tcttactttt cagacctaaa aaaaaggaca gtgcbgtgaa gccagacagg   2641 tgagtctttt ggactccagc tgagtagggg tatggggagt acaagtgagt ccagaagctg   2701 ttgctcctct ttctcctccc acccgtcccc cactttccct tttcctctgc tccccaagcc   2761 bitgttctct gccccgaccc cagctctagg gaagactctt ccttcccacc ccagacatgt   2821 cgcttctcct ccctagggct gccactcccc accaccgtcc ccagccccgt tctgttccgg   2881 gcbjggactc tgccccogga gcaccctccc cagctgacat cacccatccc actccagccc   2941 caggcccctc tgcccacgct gcacccagca ccaccagcgc cctgaccccc ggacctgccg   3001 ctgccgctgc cgacgccgca gcttcctccg ttgccaaggg cggggcttag agctcaaccc   3061 agacacctgc aggtgaggcg tctgtggggt ggtgtttgtt tgggaaggca ccaaggccct   3121 gtcctggagc aggtccaggg tgagcctgcc agtaggagga gggccaggga aggggaaact   3181 gttgaatgtg ttgaacaaat atttaccaaa cagctgctgg cacctggagc tgtataagca   3241 agtccaacat tctaactcag gagtcagata caggagggac aatgccagca gaggatgtca   3301 agggcbgtgg tgaggggtac ctggcctcgt ctttcagagg tcagagatct cttggaggag   3361 gtgacatctg ccoggagtag aaatgtagga cacagctttt ccagcttgca gttcgggcct   3421 tcccagaagc ccctgtggta gacatctgcc cttacctacg ggcttcaaga ggccagggga   3481 catagtggaa cccttgtcca cccttacctg abitgtttct caccatccgt gtcccgcagt   3541 gaggccatgg ggtgaaatca tatgggcagg gccagtgggg gctcccgagg agtgtcagga   3601 ggggatgacc tttgcaaaag gttcatcctt cgccctgcag cctccagtgc ccagggccga   3661 gtggtgtggc aggatgctca ggttgtgatc ttagtgggcc cgaggcacac atgagtccag   3721 ggcbjgggct gcgctccagc cagcatgaac agatcacttc ctccctcctc aggtgccgga   3781 agctgcgaag gtgacacatg gcttttcaga ctcagcaggg tgacttgcct cagaggctat   3841 atcccagtgg gggaacaaag aggagcctgg taaaaaacag ccaagccccc aagacctcag   3901 cccaggcaga agctgctcta ggacctgggc ctctcagagg gctcttctgc catcccttgt   3961 ctccctgagg ccatcatcaa acaggacaga gttggaagag gagactggga ggcagcaaga   4021 ggggtcacat accagctcag gggagaatgg agtactgtct cagtttctaa ccactctgtg   4081 caagtaagca tcttacaact ggctcttcct cccctcacta agaagaccca aacctctgca   4141 taatgggatt tgggctttgg tacaagaact gtgaccccca accctgataa aagagatgga   4201 aggagcbgtc cctgcctgtg tcactgtttg tcactgtcca ggctggctgg tttgggcatg   4261 aatgtctgca tcactaaatc cagagcttgt cttgctccct cattgtgcag atggaggaaa   4321 tgaggactaa ggccocacag cagatoccag gcagggccag aattatgtat tcatcacttt   4381 caagttattg ccacgcatgg gagtcaggga tagcccagtc aatacagact gcctgccctc   4441 ctgctcttca ccagggttct tttctagaag gagacagcct tctgtggcca gagagcttgg   4501 ggtaggaccc agatctactg agtgaccttg cttgtcacta cccctgcctc tctgagcagc   4561 agtttccaca tgtgcacata gagggaacag aagattgctg tggttggcgt cctcgggccc   4621 cagagaagtt tgagactatc tttacgtaat agaaaagaac acttgttctt cctgccaggc   4681 a Human VEGF-C Gene (NCBI Accession No. NG_034216.1) (SEQ ID NO: 82)      1 acttcgggga aggggaggga ggagggggac gagggctctg gcgggtttgg aggggctgaa     61 catcgcgggg tgttctggtg tcccccgccc cgcctctcca aaaagctaca ccgacgcgga    121 ccgcggcggc gtcctccctc gccctcgctt cacctcgcgg gctccgaatg cggggagctc    181 ggatgtccgg tttcctgtga ggcttttacc tgacacccgc cgcctttccc cggcactggc    241 tgggagggcg ccctgcaaag ttgggaacgc ggagcccogg acccgctccc gccgcctccg    301 gctcgcccag ggggggtcgc cgggaggagc cojggggaga gggaccagga ggggcccgcg    361 gcctcgcagg ggcgcccgcg cccccacccc tgcccccgcc agcggaccgg tcccccaccc    421 coggtccttc caccatgcac ttgctgggct tcttctctgt ggcgtgttct ctgctcgccg    481 ctgcgctgct ccojggtcct cgcgaggcgc ccgccgccgc cgccgccttc gagtccggac    541 tojacctctc ggacgcggag cccgacgcgg gcgaggccac ggtaggtctg cgttagggtt    601 tgcggagaac ccgagagttt gctttagggt ctgcggcgga cccgagaacc tgcgcggggg    661 aaagtgtgtg tgctttaagc ttgtgtacgt gggatccaaa gttactgagc tcagtgcacg    721 ctgctttgga gaaaaatctt cttcttttta aatagaaagt tgttactaga gaggcaagca    781 agttacacga gtgaagggcc cggagaggtg cccagtgaga gatcccgaaa tctatttcag    841 actggtttcc tctggggcaa ccaaggggtc ttgaaccctg cccagtcagc ggggctctgg    901 agagtatgag ttcattttgg tcgggaaatg ctcgtttctt tccccagctg attcatggga    961 ctccaaacag attctgggac actggtgatc agtcaaccca gccttacttt cctggagtgt   1021 tcatagtctg cagagcacca ggcgcbgtga gcgactttag aaaaaaagtg tcagggactt   1081 tagtaaccag gctccagagc tttcagagtt cacttgaagt tggtcagact tgagatgtaa   1141 cgggagatta gagtcagtta gatcacaatc aagcaatgca aggcttgttt caactttata   1201 agctcttcat tcctaaaatc tggtcatgag atactgcaaa ctaagttttt ttttttcttg   1261 tttgggtttt ttgtttgttt tgttttcttt taaataagag gtgtttaatc ctttgcctga   1321 aaatgttgcc aaaatacttt tgaggcatcc tgattttgaa aaaggatttg tgtgtgttcc   1381 tacttcttac tggctcttcc aaaagagtat atctttatct aaaaagttca tacctgccat   1441 aaccatatag agtatgctta agagagttcc taaagaagtt atattcgaca tttcagttca   1501 aacacttgca gtaccccttg ctggaactat actgoggtag tttatttcaa ctggtggcaa   1561 gtggagaggt acctgtggtg tgttacagtc aactttaatt tgactgttga ttaacacata   1621 cacaatgtgt agaaaatagc cttatatttt gaaatatttt atttatattt atattttgaa   1681 atacacttaa agattgagaa gactaatttt tggaaatcaa actacctttg catttaaatt   1741 ttgggaaaac attaaaatgt tggaatgtgt aataatttaa tataggggtt aaaggaatgc   1801 ctcttgagta aaaacaatat acatgaaata gaacagactg cattctgtga atcacaaaaa   1861 taattttcag tgcctatact tacattgccg taactatagt gatgaaaata tctttctgtt   1921 cttaaatacc gcagaaatgt aataatcggc tcaataacgc ttctgataat ttgagtcctt   1981 gattttgcag tacctatttg ctatttctgc aaagtcaaaa ctagtaaaag tatgatttag   2041 taaggcaaca tctctgtatt ggttacggtc acttactttg gtttacagta agaaaatgtg   2101 cagtagagag taaaatgaga aacattccct gataagccaa tagcctgtat gagagtcact   2161 cactgcbjgg tgagtctaga attaatgtac cttgagtgtg tgtgtgtgtg tgtttacgtg   2221 bittatgtat aggtatggga ttggaggatt aaaaaagtta acttattttt aactttcaaa   2281 agtgtcttcg ttggtgatgt aaaatttgcc attggtgata tggcaaattt taccattgct   2341 gtgaaaatca ctatgcattt tbitttgcaa atgtcgcttt tcatatttaa ccatttttat   2401 attctgtatg gtgaatatgg gttagtattc tgcatgtgat gtgggttcct ttcctatgtg   2461 atgaaacatc atttcccata tgaaacatca tctctgagtt ccatagacca caaagcagta   2521 tttcattgct ccattaaagt gtcgttcccc agtgggtgaa tagagccttg acagggcatg   2581 tgtcattaat gcattcagtg aaactgctgt gtccttgcta tgaaacatgt cacacaactg   2641 ccaagaaact gatatgaaga ctctatgtct ctccctagtg gcctgtacaa gcaccacatt   2701 tagatttaag cactagagaa gaactgggga gaaatcaatt gttaattttc tataactaca   2761 tgaaccccaa gaaaatattt cagaaggtaa acagaagatg ctaaatatct ataatcccaa   2821 tagatgcaat gttttcataa ctttcaccta ggaacttttt taatatttaa aaaatcaaaa   2881 atagcacaca aactatgaac caaggttagc catccagccc ttcagcccac ccgtaaagcc   2941 atgcaaaaga ttgtaggtaa aaatcacaaa tagaatgaag atctccttat tcctcgactt   3001 atatttgcat ttactggatt cctatttcta gttatttgtg gttgcatgac ttactgaaaa   3061 gtcttaaaat gtttctctga aggatgttaa cacaaacaag acagtgtcaa aaaagtaagg   3121 caggcaaaag taaaattaac tggacatgat gggaacaaaa gagaatagca agtctgaagc   3181 tgttctattt acaatttttc ttatagtata tgattatgtt tgtcaacatc tactcttata   3241 agagatttct gacattcctc tgagtgatgc tacttatatg aggttttaga tatagaaagt   3301 tcaattcatc tttcattttg atttccactc cattatagtc ttctgaacta tgaatatctg   3361 attgatagct atttattcac aagacagtta tcaaaattgc ttcatagaaa gcagttaatt   3421 actgatctta gtggcatatg tctaagaccc gtagatctct aatcctgtcc ttttcagttg   3481 agttgagaaa gacggagggt agtggattta gatttcattt tggacttcca gttctggttc   3541 cggttcctct tgagaggaag gtcctggcct cctagttatc tccatgtgtc caacccagaa   3601 tgcbgtttct cagctcttgc tggggttttc accaacagag gaactggcgt gagactaatg   3661 aaggtttccc gaatccctgg gactgtgctt gcctgcttgc ctttggcagt cctggggttg   3721 ttattgagag taggagttta taatcattat ctgtgatgtt cataacgtgt gttaagcact   3781 tcgcaaagag ctttgcaagt tagttttgtt tttcactaca cctccataat atggacatta   3841 ttttatttca ttaaggatga tgaacccaag atctgaatga cttaaccagg aaaaagaata   3901 gatgtttttt tccttttttt cttttaaaaa aagttttatg gcatatacca acagtccccg   3961 acttagaatg gttctattta ggacttttgg actttacaat ggtgcaaagt cgatagacat   4021 tcagtagaaa ccatacttca aggtttgaat tttgatottt toctgggcta ataatatgca   4081 gtaaaatact ttctctggat gctggacaat ggaagtgagc tgtgaccagt cagccatgtg   4141 atcgtgagag taaacaacag gtactctact gtatattaaa tatattttca actcaggagg   4201 aatttgtcag gatgtagccc catcgtaaat cgagaagcat gtatgtttta gagaaatgtg   4261 gtaatgggtt tgggcctttg ggcctgtgat tcagactcct ttcagcccct ctgctggtct   4321 cctttggcac actatagcag cgtgcaggaa ggcagagaaa agcactgcgt gtgactttgc   4381 agttaggggc accttgttgc atttatttag gtcctaattc cccacaacgg gacaaacgga   4441 aataaaccca gactttcttc caggctttac cacatggtgt tcgtttgact aaagataaat   4501 tataaatgac ctaatccatg gtaatattat aagaacgact gcttaactgg aggcttaaca   4561 agattttctg acaaacggtt tttcaaagtt gtgctcaagt aacttcagtg aaagattgtg   4621 attttacctc tgccaaatga cctttcacaa ataagtggat ttggaaagaa caaatttaag   4681 ttggcagaag cgttatactt cctctgactt ctgagcatat attgtttcac ctttcaccag   4741 ttacattatt ccttgtagat gtgcatttta taaatactat atgggtctac cttttgttac   4801 aaacacatat ttgtatgtac agatttgtat aaattgtgga ttaagttatc attgattttt   4861 ctcattagaa aaaacagata tagcagagaa ctttaaacaa ggagagatgc tgatgagttt   4921 gagttatagt gtaattataa aatttactat aaatatttta ggtttgtgta attgtttttc   4981 tgaaacttac tagtgtaaat ttttggggtg gcttctttcc toggttgatt aatttttttt   5041 ttcagagttt atgtttaacc atgagaaagc agagactgtt tttatttaat ttgctttatt   5101 gggcatccat catggaatta atcaaattgt acattaaatg ctttgtcagt ggattagtac   5161 tgtttcctta tactgctcgc gccctagtgg ctttcaggtg ttaggagtta tccacgatag   5221 ttttttttcc aattttgaaa tccaaaaact cattttcttt ttctttcttt cctttttttt   5281 tttttttttg agacagggtc atgctctatt gcccaggctg gagtgcagtg gcatgatgtt   5341 ggctcactgc aacctctgcc tcgtgggttc aagcgattct cgtgcctcag cctcccaagt   5401 agctggaatt acaggcatgt gccactagag caggctaatt tttgtatttt tcatagagag   5461 agggttttgt cttgtaggcg aagcbggttt caaactcctg acttcaggtg atccacttga   5521 tctcctaaag tgctgggatt acaggcatga gccactgcgc ccggccccaa aagctaattt   5581 tcttaaatta tttggtgcta taatcctgat ctgaactgac ataaggctat ttatagtcat   5641 tattatctaa tttaaatatt tctaatcttc actgggaaaa tagtaatgta tttatttaca   5701 tgatgctgcc atcagtcctg cttgtttttg gggtgtgagt attaatatgt ctatgcactt   5761 ggtttccaga aaaattccag gttcagagac tcttgcagtc tccaggcatt ttggataagc   5821 agatggattg tagccctgtt ccacaggcct tcctccattg ctttattgcc ttggggctgc   5881 ctggaagagg cagggaaagg taatccagga attcaagaaa gaagccatgt ggatgctcct   5941 aattcctttt tacccattag taccaggttt atttgctctt taatctactt caactcatgt   6001 taatcagttc ttactagtgg cagcttcagt tctaagcagg aaattacagt tcagtgtgtg   6061 atgcaaaaaa tgtagagtga gtgatcttgt ctataacaag cttataatca ttttggagaa   6121 aataaattta ctcattaaaa atactacaag tgaattaaac tataaatcca gaccatgtaa   6181 gtggttttgt aagagagtct tgtgagttac caccagttgt tggctagcct tctgggagtt   6241 gcatgggcag gcctgggaaa ggtggaatga tatgagaccc aatgttaaaa atgagtagat   6301 gctaattaca gaaatggggg agagagggat gttttgaata ttgaagaatg acagcaaagt   6361 acagaggaag taaaggtcag ggatatttgg ggaactagaa gcaaaccctt tggtgcaaaa   6421 gtcaagagct ttaagggaaa ctgaagggag catggtggga agtgtgaaaa ccaaagagaa   6481 agtctgagtt tgagttgaaa gcagcaggag ccaatgaaga ttctttagtg gtatgctgaa   6541 agtgaggttt ttaaggagct taacctggca ttgttgcaca gaagtgtcta agaaagctga   6601 ccagaagctt ctcagaagct tctcagaagc cattttcaac tgcagggttt cttaaagtgt   6661 ctggcagtga ctctgccttt ctcattacag tggccaccca tatatggtat tcgaactcct   6721 ctatatgctc ctgattgctg gcgatgatag tggtgattac ttttgactta ctgtaggcac   6781 ccatcattgt gctatctgga tacatttaca aaagtataga aatagacatc tctgccatta   6841 tggtttgcat tccaaacgaa gcaagcagtg taaacagtgg tcatgcttag atacacatac   6901 acagaacccc ccacacacat attcatgcat acaccgctta atagttcttc agactgccaa   6961 gtgtgactta cgtgttcttt cttgcatggt taagaatttg tagacagttc attgaaatag   7021 aatatttaga caatcagaag tgtacaagat tagaatctct atatttgcac acacatttat   7081 ttgtaggtca gtgggcaatt gaaaaaaaag agaaggagag aaccctaaag tgtcctggaa   7141 attcctgctt tttaaaatct gctaaaaatg agaccagaaa ggtgggagtg gggatgtgag   7201 gaggtgggta aactaccaaa taaacaatat aaatactttg gcbgttctta taaaaggttt   7261 ttttaaatat ggtggaataa tttactcaaa ctcaagagat gccacctact agagaaagga   7321 catactgaaa gaggaaatat tcaaatgcac aactttgtgt aaaaggtaat acttacaagt   7381 ttaaaagact cacttctaaa gaagtttggc ttcaacctgt cctcatttgg acaggtggaa   7441 agatgtatat tttggggtag accagaaaga tgtggtttga cttctatagt tgaaaggttt   7501 ctatttagac atttattttg taatttaatt tacctaaaac ttcatcccta aattaccatt   7561 ttctcttact tttatgcaat agtaaagtat gcagtcataa gtgataaagg ctgggatcaa   7621 agctagctat tttgctaact gcagaaccta tgcactctgt ttacactgcc tgtgatagcg   7681 cctggaagaa ctcactgcca atatttctgc ttgtttcagt cacataactg ttgcttgtgt   7741 cagtgacgta acttgtttag agatgcagtg cagtggataa gagcacaggg tatggacatg   7801 cctttctgta ttcatgtcct gaggatgcct cttagtacct gtgtgacctt ggacaagtta   7861 cttagtttct ctctgcttct ttgtagcaca atgagtagat gctaattttt aatttttaat   7921 tttttctttt tcttbitgtc tgttttgtgt atttagttac tttatctttt tttttttttt   7981 tttttttttg agacagactc tggctctgta gcccaggctg gatggaatgc agtggtgcta   8041 tctcagctca ctgcaagctc cgcctcccag gttcacgcca ttctcctgcc tcagcctcct   8101 gagtagctgg aactacaggt gcccaccacc acacccagct aatttttttt ttatattttt   8161 ttagtagaga cggggtttga ccatgttagc cagaatggtc tcaatctcct gacctcgtga   8221 tctgcccgcc tojgcctccc aaagtgctgg gattacaggt gtgaaccacc acgcccagcc   8281 tagttacttt atccttttaa aagtcctctt ccaaaatgta gaatataatt aatgcctgct   8341 taatcaggtt gttttgagga taagaatgtg tatataggcc aggtgtggtg gctcacgtct   8401 gtaatcccag cactttggga gtctgagtca ggtagatcac ttgaacccag gagtttgaga   8461 ccagcctgag caacatgggg aaaaccctat ctctacaaaa aatagaaaaa ttaactgggc   8521 atggtgacac gtgcctgtat tcacagctac tctggaggct gaggtgagaa gatggcttga   8581 goccaggagg cggaggttgc agtgagtgag ctgagatcac cccactgcac tccagcctgg   8641 gcaacagagt gagactctgt ttcaaaaaaa aaaaaaaaaa aacagcatgt gcatacatat   8701 aaagcccttg gaaccatgat tggcatatag taagctttct gtaaatttgt gttaaataga   8761 tagtcttcat gatcagaaaa caaacaaaga atatagcatg taagtactat gtcctagaca   8821 tatgacataa ctgtgattct tcagcacctt gcaactaatt tattaaattt ttaaaattat   8881 aaattactga caattttccc aatttctaaa atatagcaag aggatataat actgatgttt   8941 gattttgaaa caggtgaagg aaatgcaggg tgtttaatca ttcagtgtct ggaggctaca   9001 tactgtagtt ctgcctataa tatgttccca cttcccctgg gtgccggggt ttgttcctct   9061 cctggagggc agcacaggtg tccatagacc acaccaaacc aaagaatctg ggatgatgct   9121 gtctccttat gtgcttcatt catacttagg tcatttggct gtaaaggatt ttggtacaca   9181 taagcttttt ataatgccat ataatttaat atgaactcat cttgaatata ttcagagcat   9241 atacattttc aagtttaaat gtttattaat gaaacatgct aatgttgcta ctttgatgtg   9301 taaatatctc atctatatta ttgccacaaa aaataaatat gcattctaaa tttacaatga   9361 aatcatcaca gaatacctaa aatatcaaca atttcactga ggaaaatata aagaaaactt   9421 aaggggagaa tgctatatgc cagagttaaa cttgtgtgaa tttgtttagg aaaatgtgat   9481 tgcactgttc ctaagggacc ctcttccaga atggtaacta gtacagcgtg tgctgtctga   9541 gatgtgcgga cactgggaca ctgggatgaa ttatggagta gatactttcc ttctctgaga   9601 gtaagctgat ttgcttgagt actctagttt attccaaata gttgattttg tttggtggtt   9661 ctctttgtca atttgccagt cagtgctgtg acttgcgtgg ttaccctgtg ctgaagacta   9721 cagtgcbjgg ggcattggag gcccgtgagc agacaggaaa aagggaggaa aaatcagtgg   9781 tggacacact tcccagctct tgaacagctg acagcatatt tttttgattc agtaacatcc   9841 agaaagtatt cacttcccta ggattccagt gcagatgtta gttggagtat tttagaactt   9901 ttgaccagat accacatttt taaacagaat tttttttctg actggaactg gaacaaagca   9961 ctaaacacta aatagaccct caggtagtat gtaagtacat taaaaattag ataatactat  10021 attattcatt cacatctcta tggagatact gtatcatctt tttaaaagca attttcgtat  10081 taatatttgt atttcagaat tagaattgta tgtaagcata taataaaatg aagctttata  10141 gttcagtgct attatgtttt cccaattata gaattcaaat taacatttta atgtgatttt  10201 cttcatagta atttttcatt gtcacactaa tttatttttc tctcaacttt tttttattta  10261 aaaatttttt ttttttttaa tttgagacag gcctcactct atttcccagg ctgcagtgca  10321 gtggcatgaa cgtggctcgt tgcagcctcc gcctcctgta ctcaagtgat ccacctacct  10381 cagcttccca agtagcbjgg atcacaggca cgtgccaccc cacccagcta ttttttaaaa  10441 ttttttgtag aaatgaggtc tcactaagtt gcccaggctg ctctcaaact cctgggctca  10501 agtgatctgc cttggcctcc caaagtgctg ggattacagg catgagccgc tgttccagcc  10561 taatttcttt ttctcttaca agtgctttgc ttacattttt attgttagaa acaggattca  10621 aataactgct tatttaatat tctttttatg tagaagaaac agtcttgaac ttgataatac  10681 ttttggttcc aacttgttaa aatattggaa aaggatgaaa catttgtgaa aataatcaga  10741 ccttggcact goggtagttg aggaagagtc atgcgtgtga gtgagtgcca ctctgagaca  10801 ggcagcactt tctcccttgt ggtaattgaa tagggtatgg gaagccgact acttaatctg  10861 cttcaggcaa gcagtgttca aagtttaacg ccottttact gaaatgacaa acataatcac  10921 cttacctaaa aggatgtgtg ggtaatgatt ttaccaaata gttcacttgg tgaacaatag  10981 tgaaaacagt tcaccttccc ttgtctttgt ttacaattaa atgagcccct ccaggtccct  11041 ccctgcccca agagtggatg aatttggcaa atcagactga aatgttaaag aaaatggtct  11101 tgactactct gttttaactg aagtgaccac acagctgcca tgaatcctgt gattgaattc  11161 ctataacctg taaaagggat tgttatttcc actcactcca aatttcttgg aagtagctag  11221 ttgatatcag ataccagatg cgaggctatt ttaaatcact gtgatttaat ttactataat  11281 atcattgcct acatggaata tttttaattc tttctttttg tttgtgtctg ttttgtgtat  11341 ttagttactt tatcctttta aaagtcctct tccaagttta tgttttgaaa aaagagaaca  11401 cttactgaga ttcatgtttg cttacaggtc atgacattta tgacttccct aaaaaacaaa  11461 ctgatccctt tgtctcagag ccaaatttta gttttaacat aatagtgatt cattgtttgt  11521 tctctctgag tcctagatct ctcttttaat tttggtgtct gtccatgcca aattagaatt  11581 ttattaaggc caaaattatt catgagtcat gaccatcaca cttaacaatt gggtaatttg  11641 aagctgcttc agatacacat taaagcaaat aatgatgtca taaattttaa tgcaatattt  11701 tttttccttt aatattggta gcagtgaagc ctgctctgtt agagaccaat tctgttttac  11761 tttagaaaaa tgtacctttg tgctcatgtc catgagagca cagtgtagtt attttattac  11821 tataatatag cacacagtga cacataactt agtaaattaa agattgaaaa tatttaaaat  11881 tggtgatttt ttgtgccatg ttgatttgac atttattctt ctatctgtct aaaactagga  11941 gcagtgctag tgtgacagcc tcaagtcatg ttaacacgac acacgtagaa gactgacgct  12001 cgggcttcct ctagtgcaaa acacctgaaa ttcaaatttt gcttttctgt gctattttcc  12061 taattaaatg tatccttgat gttgagttta actttattac acccctgtta aatatctgca  12121 atgtgttggg aaggaggagg acacatatgc ctgatttaaa tttaatataa ctgtatagat  12181 ataatttcat tttccattca atcattgaaa tgatataaat taatatatgt acagctaaaa  12241 ttaaatctgt gatgtcgaga tgaactccat gctgtccttg gtgcactgtg tattacacat  12301 gggtattaaa tgcgtgctta gtgcttagtg aatgggttag aaggagtttt tttttttttt  12361 ttttgagatg gagtctcgct ctgtcgccca ggctggagtg cagtggggta atctcggctc  12421 actgcaacct ccgcctcccg ggttcaagca attctccctg cttcagcctt ctgagtagct  12481 gggattacag gcacgcacca ccatgccagg ctaatttttg tattatttag tagagactgg  12541 gtttcaccct gttggccagg ctggtcttga acacctgacc tcaggtgacc tgcccgcctc  12601 tgcctcccaa agtgttggga ttacaggcgt gagccaccac acctggccta gaaaagagtt  12661 ttaatagata cccctgtaaa atgccaagca atcagttgcc attactaaga actgcaacaa  12721 gttccagtta aagatgtaca tgtttaagag ctgtcgttct ttaataaaat atgaccaaga  12781 tgtcttaaac atgggcttta atacatgtta ctgtgggttt cactccaact taatagcaca  12841 caaagttctg aagacacatg atttcactgg tggtacattc gcacattgtt ttctgtccat  12901 gtttaagttc attcttgtcc agaacagttt ctggttttct aagcctaacg tattaacatt  12961 tgagttaatt aaatcgatag ggagcctttt atcttttttt ttttcctatc tgggggcttt  13021 gctttcgcac tgacattagc agttcccttc ctatgtgcaa taggaaaatg tgcagtcatt  13081 ccaggagcat ggtctcctca ggaggttaaa agtgattgta acttagaggt taatgtttca  13141 ctccagagga aagtgtttca coccacttga tgatgtgocc ctgggtgctc acagaaagag  13201 tagtactctt ttttaaacca aaattttaga cacgtgttat gcaaatcttc tttataaatt  13261 acacattctt ttctttcctt ttattctttt actccagtat actattttgc aattaaaaca  13321 ttttaaactt cttccagaaa aaaacttctt ccaataactt cttacttcaa actactttta  13381 ctaatgacaa aataactatg tccatcacag tgaggaatta ttcattgttt ataccacctt  13441 gtattactta tataaatatc atcctataaa aaatactata tattgggact agattttctt  13501 aaatttaaat ttaaattctt ttggaaaatc aggttctatc agctctgttg tcttttcatc  13561 tctaattgta catcttccca ctattttgat ttatacatga tgttattata ttaggatagc  13621 tttgatttta atgtaatatt agctagtttt atggcttgaa aaacttagta catagactat  13681 attcataaat acagcactat acattctagc atatggcgtg tgcacttaat ctgaagaatt  13741 agacattttt tcctgttctg tgatgattga ttgattggtg gtgggggcag aaggtggcca  13801 gtctttggca acatgtaaaa ttttgttaaa attttgtcaa actgatttat tccattgcta  13861 aattttgaaa tcagcatttt tttaggggga atatctcgag tttatgagga cagaaagaaa  13921 tattcttaga aaattgagaa ggttttgtcc ctgtacatgc aaactagggg gtgtttagat  13981 cagagcaaat gtcttgcagc aggggttgac gccgggccat gtttagtcat caaagcatga  14041 cttctattct gggaatgtgg taattgagag gtaaatatta tttacaatag cccttataaa  14101 tctttagttg ttcaacaaaa taacttgcca tcagagttag atgatttagc taaaattatt  14161 taattgggtt attcctactt gatccaacat ttgattataa tatatgtagt agcgttaaat  14221 aatttgggat ttctggcctc tggctggctg ttgaagactt tttgttggtg gcggggggca  14281 tcctaaggaa caacttgccc tctactagca ttctttacta gaaaaagctc ctatttactt  14341 gttttttttt tcctaaatat gtgttttatt tccttttggc attgtctttc ttgctcccaa  14401 ttataattgt gagcaaatag caatcgaaat tctgtgtaac ttccagcaca gtttagtcat  14461 cagagcttgc cagcaagtat gtctattgtg aggaaactgc atttgccaca gctagaccat  14521 cagcaagtga agtcgtattg tcctctgttt tgtagttgtt ttttcctatt tatgctttac  14581 tctgattcaa gttcagcatc tcagtgatca taattgtggg gaaaaaaatt cattttgaac  14641 tataaacaga aaagatacca agttgttgta tttgaaagat tattttagaa tgtggttata  14701 ccttcaagta aaataagctg taaaataagc tgaagaacca tatatttagg cacattttga  14761 ctataaaata gatcctctac atataacaag aatagctttt tttttttttt tttttttttt  14821 tttttttgag acaaagtctt gctctgtcgc ccaggctgga gtgcagtggc acaatcttgg  14881 ctcactgcaa gctccacctc ctgggttcat gccattctcc tgccccagcc tcccgagtag  14941 cagggactac gggtgcccac caccatgccc agctaagttt ttgtattttt aatagagaca  15001 gggtttcaat gttaaccagg atggtctcga tctcctgacc ttgtgatccg cctgcctcgg  15061 cctcccaaag tgctgggatt acaggtgtga gccacggagc ctggcctata tataacaaga  15121 attgctttta tatgtctata tgtcacttca taatatttgt ttattattta gctagttatt  15181 gcctataagc cagtatttag gtattatata aaatctgagg aaaacagttc tataagattc  15241 agtaaaattc caattctata agattccaag atgtaaagtg ttttaggtat ttaaaagttt  15301 tatatagaca atagtgactc atttgttatg gtatatgaat atagacaaga acttagactg  15361 aagcaaaaaa taacaattag ttacatagct atttcaaagc ccatgcagta gttttttgtt  15421 tgtttgtttg agacggagtc tcgcbitctc ggccaggctg gagtgcagtg gtgcgatctc  15481 ggctcactgc aagctccgcc tcctgggttc aagccattgt cctgcctcag cctcctgagt  15541 agcbjggact acaggcgccc gccaccacgc cojgctaatt ttttgtattt ttttttagta  15601 gagatggggt ttcaccatgt tagccaggat ggtctggatc tcctgacctt gtgatccacc  15661 cacctojgcc tcccaaagtg ctgggattac aggcgtgagc taccgcaccc ggccagtagt  15721 ttttaatgtt cagtgaagtt aaaacatctc ccgtccagtt atgctgtgta ataaatatta  15781 aagcaggaga tattagaaca atacaacact tactgtgcta tttataattt aaaatattaa  15841 agataaataa tggaataact ataaatattg atactatgat aaaactttta gcatgtctaa  15901 gttgttcatt ttgatagata caaaaaacca aagccaagca aaataaaaca cacctaaaac  15961 tttatgaatg ttaacaattt tctatttttg ccataaatct ttggccgttg caccatattt  16021 tattgaataa aggacagttg ttaagctagg gcttggtcca ctgbitgtca gtatcaggat  16081 gtgatgattc ttttctgacc catattcttc tctctctttg gctttggttc tcttgtacga  16141 ctcttctgta ggtggccttg gccacacctg tgaaatatag ggcacagttg tgctgcttct  16201 actcattgtg aacttgatca tabittttgt attgtgcctc tcttcattgg ctccttttta  16261 ttttagtgta attcaaagtg ttaattggag gttttaaatg tagttttgac caaattgtgt  16321 ttgaggtcac atgtacccag tttaaaaaac gaagaaaaaa attcaactca cttcccagcg  16381 tcctttgcag ctaatgttgc cctcgaatag ttcttgctca taagagaaaa tctagcaggg  16441 atttatggga aaacttttgc ttttttttgc taaggcactg cttttcttct tgttccctta  16501 tttccttcca tggaaatcag aaaatgtttt ataattttaa aactttacct ttgtttctca  16561 aaataacact ttcagactta tgtaaagcaa gattttaata attaatatgt tgcctcgatt  16621 atggagtaac tttccaaagt tgtactatca tgatcttaat ttattgaccc ttagggttaa  16681 gataatttgt gtgtttataa cctaacattc tttgcttggc tgatagattc ctttaaaatg  16741 ttabitgttt atattttgta catactttaa gaagctttat tcaattgcca catttcaaat  16801 aaataaaggt tctttttttt ttggtaagcc tatacctttg tttcttctag cttttaaaag  16861 tgttaatagc gtgggaatga cccttgacca tctctgattg tttgggaaat ggtaactaga  16921 aagaactgag agaggacaaa cttggatgag aagtctcaga actgatagta aaaacaaatg  16981 caaacaagaa aatatattac gtacttcatt cagattaata agtaattaaa cacttgaact  17041 attcaaaaat ctagtttgag tctaggcttt tgcaagcctg aatttgtcat cataatcatc  17101 aaaattagaa attacgaaag aatgttaatt taaatttaaa acagctggaa atacaataca  17161 tggcctataa gcttatcttc tcatctgtca acaactgctt gcatatgtca catgaactgt  17221 tttaactgca attacaaaag tcaatggaat gtttagaggt gattcaaaaa atgtgattgg  17281 ctgacatata gagttatcct aagaaacagg ctgtccaaca caattttaaa tatactcaag  17341 ctcttttata ctgattaaga gtttcaagtt aaggttttgg gttaaaaaat caacatcaaa  17401 tgataaataa gaaatataat cttgtttaaa ttatttattc taatagttta tttatgaaca  17461 caacatattt ctctttcatt actttttttt tctcagttgt aaaattctag agctggagcc  17521 cataggccaa tccgtagtat atctgaaatg attaaaggtt ttatacttga caagccctct  17581 gtctgcaggt tacttgcttc tacttggagc agtggattta tcatcctcca ctccagggta  17641 aatatctaaa agtcacttct gccacgttat ttcccatctg gtagattgtt ataatacctg  17701 tgagtcagta ttatctgcac agtgtatttc ctotgctcaa ggcactttga ccatatgagg  17761 tgttcacatc tgatcaatcg ggctgaagct tgccctagtc tgaggctgga ccaattgatc  17821 tctaacgata ttcttacctg acaatctaga ggatacaaat caagatgttt caagtgcaga  17881 aagcaacagt aaagcataag ttcttttttt ttttttgcat tctttttttt tttattatta  17941 tactttaagt tttagggtac atgtgcacaa tgtgcaggtt agttacatat gtatacaagt  18001 gccatgctgg tgcgctgcac ccactaacaa gcatatgttc taatgtgtaa tatatcttca  18061 agacagtctg gaccatgaag tgtattttta cttattgagt gtatatggga ggatcatttt  18121 ataggattgg ttatattttt ccatttcttg attctttgat acttaaattt ttggtttcat  18181 attctcctct ttcacatgtt gtccccattt tacatatgca aagatagttg tttgccacaa  18241 aaataaacat ttaacagact ccaaacacat agactgtgta attagcataa cgaaataata  18301 gtggctgagt gacgagcaga agtgattcac tcatttggct ctgtggcttt caaagttatt  18361 aatgatgtta catattcttc tctattttat ttaaaaacta acactcataa agttaattct  18421 cataattttt gcbjggttta ataattcaaa atatgaatca aaatttttat ttattatgca  18481 gtttcattct attaaaatta tctgctaaat taatattaag tagtcctata gcatatatta  18541 tttaataatt gcaagtagtg acatatcata aataaactgt ataatatgta ttattgattc  18601 tgttattttt cctagcaatg cacagggaac cagtaaattt cacaagcaga gaatactaac  18661 ttgtcattta tttaatattc taaacaaatg aagccgcctc tataagtgaa ttttctggac  18721 ttctaaagat gagcattgtt gagtttaata actcaaattt ttattgtgtt aagtaaagta  18781 tattaaatat aacctcaccc taatgactca gctgtaatta aaaaagagtt cacgaccagc  18841 ctgggtaaca cggtgagacc ccatctctac aaaaataaaa aataaaaatg aaaattaaaa  18901 aaaattagcc aggcatggtg gcatataccc aagtactccg aaggccgagg gtggaggatc  18961 gctcaaacct aggagtccaa ggctgtagtg acctgtgata gtgccactgt actccagcct  19021 gggaaacaga gcaagaccct gtctcttaaa aaacaacaac aaacctacac atgaaaatta  19081 ttgctgcttc ccatcaattt tcagtgctat ctttatttaa cctctctact atttgccttc  19141 actttttaaa attttgcttt tattcttctt tctttggtct ccttctctaa aatttttccc  19201 ctgcttctgt ttttttgtat actaggaaga catttattat ttttataggt atgatcaaat  19261 tgtaaaataa gtttatttca ttctctggtg atttcactaa ctattttgag agtatcagtt  19321 aaaatgggat ttgtttgtgt gtaacaaaat ctaactgtag tggctaaagc aaattggagt  19381 ttatttttct ctagtaacta aaaggcccca gtgggcgttt aagggctggt accacatgga  19441 gcaacatcat atcatcaatg tccagactcc tgtgcttttt tcacttgatc atttttagag  19501 tttggccttc tgtgcttcat tcctcgtggt cacaacatgg ctgattgttg tgcagcttta  19561 tgtctgattt caaggaagaa agaatagtga gagaggaggt tgttgcctta acacattcaa  19621 accaaagcaa aagttttctc tgaaatcccc agtagatttg cccttacatc ttctcaggta  19681 gaagtgcatt tttgccattc ctggctgtaa gagaagccga taaagaaaat acatgcactt  19741 tctaacaata ttgaaattct tttcacaaag aaggaaagga gaatgaatgt actttgggta  19801 ggtatcgtgg tctgttttat gttgctgtaa atcacaaact ggatgattta taataaaaag  19861 aaattagttt tcctcacaat tctgaagact ggaaagtcca gggttgcagg gctgtgtctg  19921 gtgagggcct tcttactgtg tcttctcatg gtggaaggca tcacatcagg agagatttct  19981 ccagagtgca agaacaggtg gaactttata taacaaactc attcctgtga taaggagccc  20041 actcccaaga taataccatt aatccattca ggtgggcaga gcctcatgac ctaatcacct  20101 tctgaaggtc ccacctttca atgcttttgc attggggatt aaatttccaa cacatgaagt  20161 ttggggaaca cattcacgct gtagcaggag gcaaccacat ttgtgacatt gcgtcattgt  20221 actttctaga tttgttttct ccaggttgtt tgcaacgttg atgtactctt tgtataccca  20281 cctgaaagat taatgttact gaagtattgt gtttaagaaa gaaagatgaa tgctaccatg  20341 taagaccttt tgactgtcca aaagattaaa attccagttt ggagaggtag cacttacatg  20401 aaaaccttat aaaacatgag aacttaaact tgctaatttc attgtgtcaa atcgcataac  20461 agagaaagga aaaacttgaa ggccactcct cttgaaaaag tatttgagta gtgtcgattt  20521 cagtgtaaga ccaattaaat aatgtcaaat taagtaaata taacattaaa atattttctt  20581 taacatattg gtgttgattt cacttttact ctgtaatttt tgtgacattg gaaacaggaa  20641 atattcaaat tttgccttct tttggatcgt ttcctctccg tttcttaatg tgtaaaccgt  20701 aatagggctt tctgcagcca acgtgctcat tcttttcttt ctgttaggct gtgccttttc  20761 tgagaacagt tggtactgat ggagatttct gttctttttc ttcacacaag tgtcatatga  20821 aaattggggg atcagctatt ttcagatcac aggctcctct gataacagaa taccataatt  20881 ccaactttcc tgtgttgatt tgtagatccc acactgtgtg atcatgacaa acatctaagc  20941 ataagagggc gatgaatgat taaaatttat tcactcttcc cataaaacac ctggtacaga  21001 tgcagtgtgt tgtcctcaca gaggaaaaac agtggttcct ccttccaagt ggcgtgtcca  21061 cagcactggt accagataac aagaacctta gacttttctt gttgctgcag tgtgtctacc  21121 tgtgcctctc ttaagtgtct tacacgttac tcacagagaa agaaatacaa aaatggaaaa  21181 cataagctca caaaaatgca tttagtgcat ttatgatgtt aatggaaacc ttggatacag  21241 tcctctgtta tttccttact actcttgata ttttacaata ttgctttatt attcaaattc  21301 ataatcatat atgtgttaaa caattttttt tggtaagtag actgtgtatc aaacttaaga  21361 gggatttgac atggaaagac atttaaaaga tggcagaaaa cagctattat aagggcattt  21421 gaactttaga tattttccgt tggtcagttt ccatagatca tcatctgatt cactagggtt  21481 tggccagttt atattattta aattgtttcc cctgcaactg tagtattttc tttaatgttt  21541 tgaattattc ttaatgtgac ttgaataagg gtaattgtca catatgctga tgttttccca  21601 ttaggatgaa aatatttaga aaagctgtac tagcaaaaac caggttaact tgttttcaaa  21661 gtagaattta attattttat ttcaagcttt gattcctttt ttaaaaatta agtaaatgtc  21721 cttgagagca atacctttgt gtgtgtgtgt gtgtgtgtgt gtgtgtatca gttacttgca  21781 ccttcaattg aatgaaagac agtagtaggt tgtattatgg cagaggggta gaagaatgga  21841 cattctcatg ggtatctcaa aggtcaagtc agaattggat tccctgtgga tggaagagag  21901 gagtggagaa ggtgcttctc atgtggaaaa acaagaaaag tctatgacag gcctcagtgt  21961 ttgccagctg cagtggaatt ctcatagctt gtattgaact ctgtgtccta atcttctgaa  22021 accacctcaa gagagtatat attgctaaaa taggagctca gctatttttc aggggcagtg  22081 atccagagga cactataaca gaaatagata atttcaaagt cgaaaatata ttagatacta  22141 tttttattct ctatctggaa agtctgtata gaggctttat tctggtctgc tttctcagat  22201 aaatatccta ttcaggtcac tggaaataat atgtcaggtt ttaaaagaga cttcatatgt  22261 agccaaataa acctgctaag catatttaga aaatcatgct agtgactagt gtcttaaact  22321 gtttccacaa aaacaatgct gttaatagta ggatttaccc ttttgcattg gaaatgagtt  22381 gtcaaggtta aaaagatgag tagccagata ttcttgctaa acatgttttg agaagaaatt  22441 taataatata aagtttttgt taaatgtggc ctattaattt taaacaataa tactgactga  22501 agtcattagg tagctgtgga aagaagttag cctggttttt actaatgtag cttttctaaa  22561 tattttctgc ctaatgagaa aagagggata agatccaact acaattggaa gcttaaatat  22621 ttaatcaagt ttgcagaact actattaaga tcatatgtaa ctatcagata ttttttaatc  22681 tgaggacttc tttctagtaa atagaaattt cttcccaagc attataggaa tatgtcttat  22741 tgacttattt ttttggcatg ggttactagg aaataatatt ttcagggagt tcagggaccc  22801 agatttgatt cccagataat tcagattaac cttctttaat cattctattt tatgttatta  22861 ctggagagta cagggtaggt tgaaacagca taaactgcca aatcagaact ggatttgaat  22921 ttagtgatgg gcctcaggag ctgtatgacc ttaattctgt gagtcaggct ttctgagtca  22981 ggctgtgaac tgggcaaaat agtgtatacg ttacaacatt gtaacagagc tcatttaaag  23041 cattgtctca tgttagctac tgataaagca ttagttccca ctccagggcc tgttagaatt  23101 ctaactccat ccctgtgagt catgttcatg ctttcgtggt tctcatttga ggttttgtga  23161 ccaaaggccc cacagatgga ataaaattaa tctaaatagc catttattaa tgtaatatct  23221 gctagctaat tacatattta ttaaatataa ataacaaata gctccaagat accagtgacc  23281 tccatgttgc taaagccaac agttattaga acttctctgt tctgtgagct tttctgtgat  23341 ggtcacaggt gagaccgcaa gaggacacac aggagaggca caatgaaaca aagtttatta  23401 tactcatagg tcttagacag gaggtcaccg catgccacac agggtcacag ggtgtcttag  23461 tttgttcagc ctgctataac aaagtgtctt agactggata atttataaag aacagaaaat  23521 tcattgttca tagttctgga ggttgggaag tccaagatca aggagccagc agattgggca  23581 tctgctgagg gcccactctt catagatggt gccttgttgc acgtccccct cacatggtga  23641 taggggtaag gaggaagcag gctctcccaa gcctctttta taagggtacc aatttattct  23701 tgagggctcc accctcatga cctcatcatc tcccaaaggt ctggcctctt aataccaaaa  23761 cgcbjgggtt gatattttaa catgtgaatt ttggagggac attgacatta cagaccacag  23821 cacggggggt ggggggtggt tctccatgtg gcagaagaca ggaaagagga gagagcttat  23881 gccacagcct ttactggagt ttcagggtaa aggcaaggca gagtagagta gggtaaacag  23941 tttagaactg gctggtttga atactttcag taggctctaa ggtataggat taatccctag  24001 ttgcttgata cctgacagtg ggaaattaag gcagaggaat attgtctcct ggggtatata  24061 gccagataaa ggaggtatgg ctctggattg ggtaatttgc ataccaaagg tgttctccct  24121 gctgaggttt ttgctgtctg taaggattgg cagcccctgg agggccatct ctcccaagcc  24181 ataaactttt ttttaagatg tojaaatatc atagtactca gaaaaatttg aaatatatat  24241 atatatatat atatgtataa aacatcctct tacttggcag catttacaat gtttgatcat  24301 tatttttcag ctttgtcttc aatgcactca ttttacctca gtggtggtta ctccatccca  24361 ttctccactg ctggctactc tccttgaact tttaatgtcg aagtgttcag ggctcagccc  24421 actgtcctct attatttttc atttctattc actctcttag tgatttaacc cagtcccatg  24481 gttctagata tcttcatatc tgtatcttta gtccaaatct gtcttcttaa ctttaaaata  24541 taactagctg cotttgtcat ttccactcag atggctaaca gacacttcaa atttaaacat  24601 tcccagttga aatttttatc tctccgtttc tgatcaaatt tgctctagct ctacctatag  24661 ccttccctaa ctcagtcagt ggcaacaaat tgctccgagt tggtcaagtc aaaattcatg  24721 gtatcatcct tgacttcttt ctttcctacc ctacattcag actcatcagg gaatccaatc  24781 ctcttggctg tgtcttcaaa aatataacca gagtctaacc acttgctaca tctctgacct  24841 gagccaccat cgtcttccac ttggatcagg gcagcgttct gtttaccagt ctcactggtt  24901 cttatcttca cctccctaga gtgtattctc aactgagcag aaagaagaat ccttttagga  24961 tgtaagtcac attatattcc tctcctgtta tatgtaaggc cctagaatag ttccctactt  25021 cacaaaaagt aaaaaccaaa atctctatca agtaatagta gtcattgccc tggcagtgtt  25081 tcaattaaaa gagtttaacg actggttcat tttatagagg tgtggacagt gtcaaggaaa  25141 cagaaaagaa caaaagaaca tgaagcatcc aggtactatc aacagtggga agtcctaact  25201 accctagtcc tgcaggggca aggtgagcga atagtgctat cagccctgga aattgctggg  25261 cactgtagga gaggggctgt caatagaagc tctaactgta gagtgcacac acttctctca  25321 ctatggtgag gcaccataaa tgtggtgagg cagagggaga gtgaggagaa tgaatatcca  25381 acctattttt tcttcacatc ccagccaaat acttggcatt gttagtcttt tttattttag  25441 ctattgtggt ggtgatgtaa tagcatccca ttgtggtttt attttgcctt ttcatggaaa  25501 ctgatgaagt tggacatctt ttgacaagct tgttgcccat ttggatatcc tcttttataa  25561 aatgcctgtt taagtgtttt gttcattttt ctttttggtt gttttttttt tttttttttt  25621 ttagatttct acaattcctt tacatgattt ggttgccagg ctttttaaag ctgtgtgtat  25681 tgcagatatc ttcttccatc tcttactggt cttttttctt tctttctttc ttttttttta  25741 ctggccagat ttctttaatt ttaatgtaag gtgatttttt cttgtttttc ctctatgatt  25801 aatatttttt atgtcttgtt taagaaacat ttgtctatcc aatgttatga aaatagtctt  25861 gtagaagctt tattgctttt tcactttcag atttatattt acgatcaacc tggaattgat  25921 atttgtgtag tggggagggt agaaatcaag actagttatt tttaatttgg ataactaggt  25981 aacctagcat atttctctgc tgctctgtag cattaccctt gtaaataaat catgtctcta  26041 tacggtttct ttctggactc tgttttacga ttgtatgctc tctggcatta gtatcacact  26101 gcctgaaatt ctgaagttcc atagtatctt ttcttttcct tgtttttttt tttttttttg  26161 agacagagtg tcattctgtc acacaggctg aagtgcaata gtgcaataat ggctcaccac  26221 agccacaatc tctcagggtc cagcagtcct cccacctcag tctcctgagt acctgggact  26281 acaggtactc accactacac ttggctaatt ttbitgttct tctgtagaga taaggcttca  26341 ctatgttgcc cagactggcc ttgaactcct gggttcaatt gatcctcctg catcagcctc  26401 tgaaagtgct gggattatag ctgtgagcca ccatgcacag cttcattgta ccttaatatt  26461 tgacagaaat acctacagtt tgttctttaa tatcaccttg aatatagata ttgagattcc  26521 attgaatcta aaaattgatt tggggaaaac tgatatatta gcaataatgg gctttctatt  26581 ttggccttat agcatttatc ctattatata atcattttta agtttttctt tttgtgtaga  26641 gaccttgcat atcttccttt toggtaccta ggtatgagac attttggaag ctatggcaaa  26701 ggatatttgt ttttgcattt cattgtcttt ttttttctgt gtatagtatt ctaggttggc  26761 atttattttc tatattctaa agattttttt ccatattacc ctctgttttt tattacatcc  26821 actatcaatc ttattgttgc ttotttgaac aagaaatgat tttcactgtt agcatttaaa  26881 attctgtctt tggggccggg cacggtggct cactcctgta atcccagcac tttgggaggc  26941 caaggcaggg ggatcacgag gtcaggagat tgagaccatc ctggctaaca cggtgaaacc  27001 ccgtctctac taaaaataca aaaattagcc gggtgtggtg gojggcacct gtagtccagc  27061 tactojggag gctgaggcag gagaatggcg tgaacccagg aggcggaggt tacagtgagc  27121 cgagatcacg ccactgcact ccagcctggg cgacagagcg agactctgcc tcaaaaaaaa  27181 aaaaaaaaaa aaaaattctg tctttggatt tcagtagttc tattatggtg tagtatttta  27241 gatgtagctt tcttbitgtt taatctgttt gatgatcata gcaatttttg aatctacagc  27301 ttgatgcttt ttgttatctt ggaaaatcct agaaaactac ttctttaaat atgccttttt  27361 ctttatagtc tctatcctcc agttaaatat atattaaaca tttgcagtat ctgctctata  27421 tctctatgtc acttttccaa tcatctatgt ctattatgct tttttttttc tagttttctc  27481 tggatgtttt ctactgatct gtcttccagt tcactaatcc tttctttagc tctaatatta  27541 ttaattccat atattgagac ctattttcag ttattacatt ttacagttct caaatttctg  27601 ttttgtaaaa taaattctat tctttgctca aattcttcat cttcctttct gttttctcaa  27661 acatactagt tgtagtactt taacaatacc tatttctttt ttttgaggca gagtcttgct  27721 atgttgctga aggtggtctt gaatttctgg gctcaagaga tcctcccagt tcagcttcct  27781 gagtatacaa tacctatttt aatatcaagc acaactgaag tttcattttt attgtctatt  27841 ttttctattt ttttgttagt cttatttgtg gatatttttc ttatttgctg aaaacttttg  27901 attgaatgtt tgatgtttta tttaaaaatt ataactgtct agactatgca gttttgcctt  27961 tctagagagg attcagtgta tcctctggta atcagccaaa aggcagacag atcactccag  28021 ttccattaga atatgacatg gctagaagct tttctgaagc ctgbitgtat cagtctggta  28081 tggcctaccc actttccttg ggagttgtct ttcaggatac ccattcagag cctatgaatt  28141 tatgagattt tttttctttg gtgggttctg aacttcaatt tttgtaacct ctgcactatg  28201 agactgttgc atacattctt gtgcttttca gaagatattt gcttggcttc tttgcttctt  28261 accatggata atttgaaaac ttagtgcctc aaaaggaaaa ccttaagtat cagggaacct  28321 catttctctc ttgttttgtg taccctctgt ccgtgatctt agcccctcaa atctgactgc  28381 ctttaaaggc ccaaacttta atgttttgtc tctccagctc tgtgaaaatg ctggcagtct  28441 cacttttgtt aactctgttg ttttctgcct ggattttcag cctcttacct atccaaggac  28501 tatcatatta tattacccaa gggaaaatgt tgctctcata atgtctgctc acctctctta  28561 ctttatgttt ctgcccagga tcttggcaac tgaaagcttg gctgtctcta tggttatatc  28621 ttcaaatagg tgtttgttgc ttttcgtttc atctcatatt ttctagttgt tctcagtggg  28681 aacattgttt tgtcacaagc tattccatca tggtcagaag tggaagttgc taagtcaact  28741 accttgataa ttattgtgcc gttagtatgg cttagtgact aagggaacac atttttgttt  28801 ggataggcct ttggtttaaa ttcctcttac tatgtttgag ataccgttcc attgaaaact  28861 tagttttatc acctgtaatc agaaaaaaaa agaccttttt ttagaggact cttaggagga  28921 ttaattggaa aatattcacc taaagtactg attacaataa ccatcacata gtaaatttag  28981 taaatatgtc tcaaatgata cagaaacctt atggaacctg taaggttaaa tcatgcattt  29041 ctgaaagtag taataatatt tactttactt ccagtgggtt aatatgaacc aaattatttg  29101 aagatatttc tattaaatat tgattacgtg aaagaatata acatatactt aagatctata  29161 acaataaatg aatgccagtg taccgctact caagttaaaa ataaaatact accagtccca  29221 ttgagtttta tgtatatgta ttccttataa atatttcatt gagtttttgc ttttgaaatt  29281 tatgtaattg gaatgatgtt ctatgcacct ctttgcaact tgcattatta taacttgctt  29341 tatcttaata tcatctctgt gattcattca tgttaactat agtttttttt cattttctct  29401 tattttcaat gtggtgagat tatgttgtat aatatctccc aaatatgcat ttattattaa  29461 tagaaatggc gtgctttttg atctttcact tttggtcctt tttccttgga attgtatttg  29521 ggaattagtt gaagatgaat ttctctagag cagctttttg tttgcttgtg ctccgcacct  29581 gtggacacta taaatagaga ccactttcaa aggtattttt ggcttaagtc tgctcgaacc  29641 acacagatag tgttacttca gaccacaact aggatgagag ctttctcctg attatatccc  29701 aaggaggaga tttctttctt ccttttaccc agagcaaatg ttgagacagg caaatttcct  29761 tgcagtctcc ttctgtagat cagagttatt tttctagttt gcccttatat tgagaggaca  29821 ctatagattt gttctagctt aacttaggga actactatta gactctttaa gagagctctg  29881 ggctctgttg cctgttaaac tgtcaagttc aaagcccagg ttcaccagct ggagcaactg  29941 ttccagggtg aatatgactt agtgttgaat actctctgaa ttatttcact ttatttttgc  30001 acccctagga atactttacc ttcttaatag atctttatat gcagacacac atatgtttaa  30061 acatatggaa gtacatatgt gtgcatgtat gtagataaat agatagatgc actttttcag  30121 aaagagtctt ctaccgaact gttagaaaca gaaatgtctt aagtctgatt tgtgctgctg  30181 tgacagaata cctaaaactg ggtacatgat gaaaaataga aatctagttt tcacagttct  30241 agagattgaa acgttcaaga tcaagttgct ggcaggtcag gagcctggtg agggccccgt  30301 ctctgcttct aaggtggcgc tttgaaggct gcgtcctctg gaggggagga atgttgctcc  30361 tcacatggca gacggacaga agagcaaaga gatagaaccc atgatacatg aaagcccttt  30421 tgtaaaggca ttaaacccac caatctgggc aaaggcttca tgacctaatc acctcttaaa  30481 ggccccacct ccccccatat tcttacattg gcaattagaa ttcaacatga gttttggagg  30541 ggacattcaa actataccaa gaaataactg attcagtttt tataagaaat tttagaactg  30601 tccctaagac ctggtgagtt tcaggcctca tgttctgagc ctacatctga catcagctac  30661 catagtatcc gctgtgcagg cagagcctct tcagtcatag gtatggggtg aaacagattt  30721 ccacctcttc cctgagcttc gctggcacag aataaatgca ttctaaagaa aactgatacg  30781 tcagagacat ctgagcttac tcttaattgc tttcttacct ttctctgtct tgggccagat  30841 tttcttccag gctgatggct tcttccaact ctgaattcta gcactctctg ctgtttcatt  30901 ttgtattcca tgccttcgtc tcttctctga tcccttccat ctgcctgaaa gcacttcctt  30961 tttattattt ctgtgtccta taataataaa gttaacaaaa gtgttaagta tatgtttatt  31021 tttccaaggt tacataggca catgtataat gtagggaaac tggctgacaa tcagagacag  31081 aagacacata cacgtgggcc cacacacatt cgttcactgt tgtccttaat gcagtattca  31141 acattacaaa ttactgtaat cttaataaaa ctgcgacatt gttttccttg tttatttagg  31201 gagcaccttt aaaaatcatg tatttgctga tttattcatt cactattgtc cttaatgtag  31261 tattcaacat tccaaattcc tgtaatctta ataaaactgt gacatagttt ccttgtttct  31321 ttatttaggg agcatctata aaactcatta tttactcctc agaaaacttg catgggcata  31381 tagttatgaa ccagtttgaa tattatgatt ttatattcac aatattttta tacttatgat  31441 cctaggctaa ggatatttat attagaatgt tcgctgagga cttaaataag ttctcactga  31501 tacttacact gaatattatc tcaatgtact tgagagaaaa ggtattgcaa gtaaaggtaa  31561 atatatgagt acatcaattg tataatttaa ttttctcaca attttaggac aattttgtat  31621 aggatctata atcatatact tttttaaata ttcacttgct tttattaaat caatcacaag  31681 aaaatacaga acgttttccc cttccacttc tgaagtggag gaaatcactt caaattcatg  31741 ggatctttga actttgccca ttgggccaga cttgcagtat cataaacttc tttttcctac  31801 ctatgtatga ttttgccatg tgcgaaacaa tcattgctag taccacgagt gagtgatgat  31861 aagcttagaa tacatccagc taagatcagt gccatttgaa gctccctcaa tatcgcattt  31921 cttcggttct ttaaaaaaaa ttcattgttt tggagtcagc atattattaa tgaatggagt  31981 atttgagggg aataaatatg actttggcaa tatcacatgc atgggaaaaa ttggctagag  32041 aaagggctaa gtctttcatt ctgtgtttta gagaacagct ttagctcgta tgaaaaaatt  32101 ctggcataga tatgtgaggg ggagtgttgg ataagaaaag gaaagagaaa aagcttgctg  32161 tggagtggaa ttctcatcac atttctttct tacctactac tctggggaaa cttcagttac  32221 agggctgata aatatttatt aagaatatat agacagtata acctaaaaac attggaagat  32281 attttagcga ggcttgagtc agattaaatc taccaaccgc taaaagatgg ctttgcctag  32341 agaaattctt ttttctttgg gagcagctat tagggaaaag cctattgcct aatatcttaa  32401 ttgaaaccta tgcataaaat tcaattaaaa atggcctata ttttgaattg tttttcaagt  32461 tacagaagaa ctttaagatc tttgtaggta atttctaaaa agcataaata tcttaaaata  32521 tatatctgta ctatcaccat taaaacttac cattctttgc tctatatttt ccaaagctat  32581 attcagagaa aataaaacct attatttcat agcctgcttt aaaaatatct cttaaaatac  32641 gctatttttc atctcctgat ctatccctca agaatatgat tttaaaactg cattacctca  32701 tttcgactta tttgttttat gtcctccttg ttattaacta tttttaattt tttctgtgta  32761 aaaacactta tttctttaca tattttctct aaatttggaa gctatgcctt cgtcaatgat  32821 accatgttaa cattttaaat ttttaaaaat attttaatat attttattca aacagtccca  32881 ataattaaat ttatttcact ggcaaatgcg atataaacca attgctgcat ctctcctctc  32941 caaaaagcat gtcttgttct agtgatgtat ttggagatag aagacttaaa ttattttatt  33001 tttttttact ttttaaaaat gagaaatgaa aactojgcta tatgcatggt gtacactgtg  33061 acgttttgat tgaagtacat tgtggaatga ttaaatcaaa ctgattagca cattatcatc  33121 tcacatactt atcatttttt gtgatgagaa tgtttgaaat ctactctatt attatttacc  33181 atagtcacca tgagtatatt acatcttcag aaattatccc ttctgtctaa ttgaaactgt  33241 accctgtaca caacatctcc ccgttgacca ccccaccagt ccccgagccc ctggtatcca  33301 ccattctact ctctgcttct atcatttgat ttttttaaat ttctacattt aagcgtgatc  33361 atgcatattt gtctttttgt gcctggctta tattgctaag cataatgccc tttagtttta  33421 ttcatctttt tgcaaatggc cggatttcct tcttttttat ggttgaacaa agtacctttt  33481 ttccccccac tgtcccaaat atatgggctc aacccccaaa ttggcaggtc taagaagtct  33541 ttccaaaggg tagtctatta catttaattt ctaaacataa gttgaagaaa agaaaattta  33601 tcctgacagt tccaaagttc aataaaaagt atagtttttg agtttttact tcagtaaggt  33661 attattttag tttottagct tttcagaaag totcagtott ttcaatggga aactctctta  33721 gggcatttaa aatataattt gctaacaatg aacttttaga tgagtaatcg tggctgctat  33781 cactggccct ggatggcagt gggatgagct tgcaatgcca aggatacagc tgagcaaatg  33841 ccactggaag ctaaataaca tgaaagaaac cagggttttg ttgtttacaa tggccatgtg  33901 atggtatgag tacaggaaag ggctagaacc tgggcatctg aggagaaaaa gcattgacag  33961 catggatgta aatgacgact ggtatttgaa tgcaatgtgg ggccagaggt agacatcatg  34021 gaaaagtatc agactttgca tacaggacac aaactaaagt aatcactagg gttagaagag  34081 gagcccactt tctggagata ggttactcag agcaagaaat gcagcaagtc agaaagctgt  34141 cgatttggga agctacttat taatgtacct tacatcctcc ctgacaacaa tcgagattga  34201 taaccacatt taattcagtt ctagtcagta agacggaggt tttctagcac cagctgccaa  34261 gattaaaaaa tgtgcatgtc ctagctctgg gaagtgtctg gtatgattga tgcttggtac  34321 ttgttcatct aaatatgaat ttactactgg gaaagaaatt aaacttctag atattcattt  34381 ggtagatcgg tgaggtgact gaagtgtggc aaacctcaca atgattatga ataaacttta  34441 ttaagaaaaa ctgaggcaat taacttattt gttcttcaaa actgaggaaa tatttgtcct  34501 cacatatatg atagaatatt gtttgctgct ggtaaccaat ctttgctttc ttctactaac  34561 aacttgtttg tcaatatgtc ttatttctca ctctaataag actatgtcta aataacttct  34621 ctcctaaggg ttaaaaatac aaagaatttt cacacataac caagtaataa agaatgtata  34681 ttattgaatg aatgagtaat ttacaaaaga aagtgttgag aagtagaata cataatttca  34741 gatttatgaa atatgaaatt tcagattcag gatctgtcca gtggagttgt gtttttactt  34801 ttatggggat taagtcaaag gcagtatatt aaatataatg gaataatatt cccccaaaac  34861 atggtaaatc tatactttcc ctgaatataa attttccttt aggacaccaa atctttaatt  34921 aggttaatta taatttcagg tagattaaag aggactattt ctctttaaac ataaggataa  34981 ttatatgaga attaaatctg tgagaaagaa ttggaacctg aaaaagacaa tggagaaaac  35041 tagcagacgg tatgttcaac tagaagaaag agaatttaaa agttaaaccc aaggtggtga  35101 ataatcacaa aaattgttaa tgaagagcac tttttttttt ttgctgatgt tctttaaagt  35161 tttttagccc tggtaataca tatttagaat tattttagaa tttgattatc tatgactgta  35221 ccaatattat tgtgttagca gtatgagtct tgctttctat tattgaaatc gttgttaaca  35281 gatcaaatta cccattatag ttttatgctc tgtgcataca gtggcatgac ttagattaga  35341 agaggtggat aabittgttc tcatattgat attataagct tttatcacag atctagggac  35401 ctttgtcttc taattcttgt gtgtttatta ttgcttattc cattcaattg gcatgtaatt  35461 gaaatggaat tgaagacaag tacacatgtg tgttccttta tggcccctaa cattcactgt  35521 ttagttatat aggtctagat tatgaatggt gcctagaaaa aaaagtatga ataaggaata  35581 attaataatg aatacttatt tccatcacct gttaacatac tctgtccatt tattcctcat  35641 tttaccgtct acatttaagt tctcttttct agccaccaag cattattgtc tagctaccat  35701 ctactgagtg tttaatatat gtccagaatt gagcagagtg ctttgtatgt aattcatata  35761 accaatctag caaacatcct tgatttttca ttttacctag ttgcctaaac cttccagcaa  35821 tctattagga agtcaaaaag cttctcttcc tctgaaatat attccaaatc catccatttc  35881 acctgttatt cttctaggct aagcbgtcat catcctttgc tctggtgatt gcaatagaac  35941 ctaattgtcc tatctttttc ttgotttaca ccottaaaat ctaatctact tcttgaaatc  36001 agggtgtgtt tcattgtaaa tgagataata tcatttctac atcttaacct agcagtgact  36061 tctttccatc atatctggac taaaatccaa actctgtatg gatgataaga cctatcagaa  36121 ttggagtacg tttttttcat ccccatcaca tgccatgccc gttcttttca aaaggctacg  36181 gctctttctt gtctaacatg taagcacatt cttttcaaag agcctggaat gttcttccct  36241 agatgggcat gactggctct tttttgtgga ggtcccagct accaattcct taagggaatc  36301 tacccttcct tatctgttct aaagtagcca cccagtttct atcatgaccc tcagtttatt  36361 gtcatcaaca cttcattttc ttcatttatt gtttattcct taattgattc tacttcttta  36421 gtagaaattc cagaagcttt aaagtgtttt gttcatagct gaatgcccag aacctagact  36481 aatttttgac attcaaaaaa tagcttataa gcatttagta cattttatta aataagaaaa  36541 tagtatctcc tctaatctca gaatattata aatttatatt gttattatca cttaatagat  36601 ttaaaaagtc atgaatgtgg gagataagcc cagggttatc cagttatttc agtggcagag  36661 tcagaatttg agctcatgtg tttcagacct tagaacttta cctatagtct ttgatgtcta  36721 catcacatta tgctccctcc catgtaccaa attattctct taacttacta tatcaactaa  36781 tatatctata aaataatctc tggcatagga atatagcatt catataataa atcattactg  36841 taatgcgttg acaatgcatt acagtaaata atgcattact taacctgata cattattcag  36901 ctgtttagat gagtcatcaa cctaaaaata tctgactggc tgtacagtaa tgtggtaata  36961 cattcatcat agagaaatta acgtatgggt tgaatattca tagtgatatg aatacaaata  37021 tgbitatcag taggattatg gatgtatgat agtttagtat ttacctagca tgtcaatgga  37081 tgataacaat tatctgcaaa tatttctgag tgttttaatt tgggtttccc tagaagtaga  37141 ctttgagaca gggaattgag gcaaggagtc tatctgggag gcaatcccag ggcactttgg  37201 caggaaaatg gtaaaatgag acaggatggg agaggaccca ataaatggta tgttatcaag  37261 cgagctatcg ttatgggtat ctggagttta attctacagg ggactctatg aaacagtgta  37321 gaacacacaa ctcagactta tcctgaccaa gatgcaaggg agcbjggtat ttatacaaaa  37381 agtcttgtta aactttggct tagggctgct ctggggagca taattacttg tctcctgtct  37441 gctgtaagtg ggcagcatgg gttctggcag taagagcaaa aactcaggga ataaagtgga  37501 gatgataaca gttgaaagtt ggactggtat ctactgaaat actgagacca tggacagctc  37561 gcaggctatt aacaaggtct tctaaactac tcatatatgc atggtaatct gcatgcattt  37621 ctgaatgtat acatctatac gaattggaac caacagatga aagtaactac atgaaaactg  37681 tgaaatatag aaattactta cctgtaatag gacagataga atatacagac aatgctctta  37741 agttcatggg tttctatttg aatgtatatg ttggtgcaga ccctgtgaca atctgtattt  37801 tcaggaattg taggtatatt tgagaaagtt atatttttat gtaatatata acagttctct  37861 ttaggactta tcagtggata tcctaagaaa cttttaaata ttttcctatg tttattcatc  37921 ccacttcaca ctggtataga tagatagttt tttgataact caaatctacc tgtggtaagc  37981 agaataatgg cccccaaaga tgtccacaac ctactccctg gaacctgtgg acttgttacc  38041 tacatggcag aaggggtttt gcaggtgtgg ttaaattaag gatcttgaga tggaaagatt  38101 atgatcctgg attatctaca tggttccagt gtctttacag gctctttata agtgaaagag  38161 agaggatgtg gagtcagatt cagaatggtg tgatgtgaaa aagactcatc tggtcattga  38221 tggctttgaa tgtggaagga agccatgagc caaggagagc atggagcttc tagaagctag  38281 aaaagggaag aaagtgtatt cttctccaga gccccttaca ggctttgcca gacaccttga  38341 tcgtagccca gtgaaaacca ttttggacat ttcacctgca aagctgtaaa aaaaaatgca  38401 tttctaatgt tttaagcaac taaacttgta gtactttaca ccagcagcaa tgagaaacta  38461 atgagctacc taataaacac agaggtaaag tcacctcaag taaaaaaaaa aaaaacaagt  38521 taagacctat gttttaaagg tcatagcagt atttccactg tccgtatgtc actgcagtga  38581 taaatgctgt gttttgacca ttgaaagaat tojaaattcg agtaagcaaa actaagttgg  38641 aattctgcct aattactctc tatttaacct cagataactt ttaatttctc tttgctttat  38701 gttcatcatc tggaatatgg ttacagtaat aatattctga cttccctcat gagttcattg  38761 taagtattaa tttgaataac ctaggcgaaa ggacgttgta gtctgcaaca tagtacatgc  38821 aattttattt ggctttgtta gcaaataata gtgctaaaag aaatcagata tccaaaagac  38881 ataaattaaa ccacataatc ctagtcaatt tgtagatttc tgagtatttc tgtatcaaac  38941 tggcaagtat atgctatatt tatgatgagt aagtcataac agttaaaaga ttgactatta  39001 attgagagta aaaattgtcc ttgttattgt cttatgcatt ttaatttgca ttttctgtgc  39061 cttaaataga aatattttaa aacaattcat gtatgcagga ataaaagcac tttagtggac  39121 tattaaatgg taaacttctc cacatcattc atgagggagg agttataaaa ctgttctaac  39181 tctcaatttc ctaaaacttt ggtaaaataa tattctatct catattctcc cttctgtatg  39241 tctttatgtt tgcaaagatt ctttggggca cagaaataaa caaatcatcc ctatgaaagg  39301 gtcatcgtag ctgccagtga ccaaaagagc tgcctgctga gcagtttcat actgttactc  39361 cagctgccat ggactcatgc gtgaggaatt cacacagcta atcaattcca taaggtgcag  39421 ttgctggctt ctctcttctt aagcctgtac ataaggaatt ggcacttgag tgtttcatcc  39481 tgtggactct acatcattcc ttcacaccct ctgccatttc ctggccctcc ccaaaataga  39541 cccaaagcaa aacaataata aacaatttgc tgtttgattt ttagtcagca ctaccattca  39601 ccagccctta agaatgccac agcagctgcc tgtcactgac bitttcagca ggatcaggct  39661 agaggtagga gaggcggggc aaaatttctc ctccttgtag gttttagtta attgctgtca  39721 atgacaacta gcagttgtgc acctgtttcc atgcatttag tttctaccct ccatcaataa  39781 attctaacaa ttatttattg aacatattct atagttttgg tccttaaaat aacatctgat  39841 tataggtact gttgttatca aatgaggaag cagacttcac aaatagcaac tgggccacaa  39901 atcttgctac caagtgtcct agccagtggt cttggaagtc taggctcttt ccctatagcc  39961 cccctgattt tattagccaa gttctaattc taacatggga aagtcctatt tcttagttat  40021 gtgtgatgta acttagattt gtgtgtaagt tattatttct tagttttgtg tgatataact  40081 tacattatca tgtacatgtg cacatttaca tcttacatgg gaaattttaa tcagaggatg  40141 tcttcatctt tgcgtcacta ctgaattgac taaagactca ctcaaagaca tttccgtttt  40201 aatagtgaag agaaggaagt gattctcttt gcatcttatc ccttcatcct acaggcattg  40261 tgctcctact gaacactgaa gagtagtttt gttggcagta accttagaac gtttggagtc  40321 aaaagttgtt gtctctatta cactcagatt gtagaaagtc agcaggccat tcggagtgcc  40381 aatatgagct atgtaaaagt catctcaaga ctggaggaag agtgactctt gaggccttta  40441 ttttccatat aaattgtgcc ctctgtttcc tagcaccttt caggatccgg ggcagcctgt  40501 ctgccatttt ccacttgttt agggctttaa aatcgtaaag aacttcatta actccatgaa  40561 ggccttcaat ttaatattga ggatactgga gtatttatca cagaaaagat acagctcaaa  40621 aattttaacg caatttcatg gaaaattaaa aaaataacta ttacattttg gtaagacttg  40681 tatactgaat ttttcagaat gtaagctaaa ttgggtttaa tcttatattt tataaaaaca  40741 aagaaatatg aaatttatcc atttattttt tttttcttta tgacatattc caaatataca  40801 gaggaggaca gagacctaaa agcctcaggg acccatggtg gggctctatc aaattctttc  40861 attttgcctt atgtttccag atattgttat gagaaaaaaa cttacaggta aattgaagac  40921 ccccatataa gccttcagaa atctcattcc ccttcctcca ccaagttaac caatattctg  40981 aatttagtat ttatattttt atgctttttt tttacgttta cacatatcat tgatctatcc  41041 aactttttgt aaattatgtt gtgctgaaca tacattcttc aacatgttat tttctgtttt  41101 bitttatgtt ttattttagg gattaagcct tgttgatgcc tatagcttta atatatatgt  41161 agaaatctgt tgtatgaccc atgggttagc aattctctgg taaaggatat tccattttct  41221 tcaaacattt tgctgctgca attagtactg tagtgaacat tttgatgttt ccttataaaa  41281 agaatggtgg tctttttagt ttgtaggaat tctttgatca ttctattaat cctttgtcaa  41341 ttatgtggtt gaaatgcctt gaattttcaa atttatttgt atgaaaatac tgacagtagt  41401 cccttatgat ttttgccatc cattctataa agagctattc gcgtttcaat tctaaaattc  41461 tttgtaagtt ttctctttca ttcttggaag actgttbitt tactctttag tctcttcaaa  41521 gaattttgtt tggttttttg gctctctcta tttctgtgtt tatatttcac tattttatac  41581 tgttgctttg attaaatcct tccttttaga ttgtttaagt acattttcat tctttttcta  41641 acttcttgag ttgaattacc ttaaatttat tattctcagt cttatagttt ttaataaatg  41701 tatttcattt attaaataaa tgtatccatt tctcttttaa cttcttccca caagtttgga  41761 aaagtattcc ttttattgta aagttctggt tctctttctt ttttttcttt ttgtcctatt  41821 gggatttcct gttataaccc atgggctact gaagttttca aacgtataga aattttttgc  41881 agaaagtttt tgcagtatct attaattaac gatttctatt gtaacatcat ggtaaaaaaa  41941 cattggttct gtaagatacc aattctttga aattgtttgt gatcttttgg aacccagctg  42001 gtggtcagtt ttcataaata gtttttgtgt atctgaaaaa gatgtcaatc cagacaggat  42061 tttatatgta tacctatgag aagaaacttg ttaaatttat gttagatctt ttctatttta  42121 ctaaattcct gcttcccctg aagggtttag gtatgcaagt cctttagaaa tctaaaggta  42181 gtaatgttag gtttataatt gaaatggctt ctcagtggac tctacgtctt ttactgtatt  42241 gtgaaccctt tgatgcattg ttttacattt ttttcttact ggcattagta ttactacata  42301 tataaatttt tttcaagtta gtatctatat agtatatttt cttcagtctc tattttaaac  42361 tttcaaaaca aatatagttt tgttttaggt tattcttgta atcatcatgt agttttataa  42421 aaatctaatt tgattatcac taatatgtga gtttgataaa tccacatagt cataattact  42481 gatatgtcac aacacagtaa gggcbgtggt cttcatttat ctgaacaact gctttacatt  42541 tagtttcaga gatcggagta ataatgaacc tttctgcatg tacccagtgt tatgactcct  42601 gtaaggatta atttaaaaat gttcaatatt tattttcctt ttggattttg ctgaaaattt  42661 aattttagaa ataaaaaaaa tctctagttc tttcaaattt tccatgaatt gaagattgtt  42721 taccgatcta tttttttaat actgcatttt ggcataattt tttaataaat gtttacactg  42781 taattttcag taattcagtg taaagctaac aggttttttt caaagatgaa gagacacaat  42841 atgttataga atatagtaca tggtgggaca gttaagtagg ggttctggag tttatttttg  42901 cttctgctac ttaactatgt tattacaaag aaaaaaatca tgtaagagac tccgccaaat  42961 tctcttctgt ataacaagag ggagtgacat actatctcaa tttcagtttt catatttaat  43021 gactcacaat tggatttttg gtatatattt gaccactttc taagatttta ttttttatgt  43081 tcttgaaaat tttatattct ataaatattt ttgtatacat atgtacctca cattcaaggt  43141 aagaaattct taagtaattg aactttgtgg ctataattaa atatatacac taatagatga  43201 cagaataaag aaaatatttt tattctgaga gcctaatttt aggtaatgaa aatcatttta  43261 tgggtaaata aagtacacat tttatagtgt gctaaaaaat acacaaaatt tgacatttaa  43321 aacaataaaa aatattaaat aacttggaat gaaaggagca tatcgaagta tttgtgaata  43381 aataatctca aattgatttt ttccaacact ataacatctc ttttctgttt aaaagaagtt  43441 taatagttgg ttcaatcttt tctttgagtt tgttttttat attttccaag cttttaattg  43501 tcagtggagg gagaggactt gagtgttttt aaggtttcca tcaacatcca ttctcctgta  43561 ttcattgtta ggccaaaagg actcaacatc tttgagtctt ccctatttga gaccaagtct  43621 atactcagct tctaatttca gctctagctt ccattcactc tcagtctttg ttagcattat  43681 ctaagtttag gttgagatta ttgcattatt gacttgcatt ataaacttct tctttcaaga  43741 ataatatgac cttttaatct tgttatatat gtttacccat catttacata aatttttatt  43801 ttatattcca tatggtttta ttccaacagt cttttgtagt taaatatttt atactcattc  43861 atcataaatc ttcaagtaat ttttagaaga attttgtaaa agtatatgac ttttttaaat  43921 tttgtgggta gactatatca ataaaatatt taaatatatt cagaaacttc ttttaaagtt  43981 catatcactt tactttggta aagagtttta gcaaaagctt ataattaaaa tatgcgacag  44041 tgctcacaga gcatttctga ttactatcag aaataggggt ttattctgga aagttgtttt  44101 cctgaaagtc ttaattgtaa aaagtgcagt ttaataccta ttatattctt atgtgtatat  44161 taatgccaaa ttaagcaatc ttcctccctt tctttcttcc ttctttcctt tcctctttcc  44221 ttcttttctt cgtttctata tttatgctgt atacgtacta cttgaaatat ccagacacta  44281 ctatttgttt aattcacaag ccatatctgg tgatatggat attattgttc ttgtttcata  44341 gttgaagaaa ctgaaacttt aatgaggttg gataagagcc acaagtatag cagattttat  44401 agtgtataac cctgcaaagc tcaaatttgg attgatatct ctgtttattc tagaaccctc  44461 ctctgtgtca ttctatgtca gtttgctttg ttgtttatta tggtaaagta atcattcttc  44521 acttcaacag ttatctgtga gttgattcta aaacatagaa aaattttgtt ttaaaataaa  44581 ttgtatgtat gtoitcacct aataatgggc ctatgtgggg tccacacaaa accagtttgc  44641 tgcagtcttg gcatagtgta aaattcccaa agtttttata tacatattga atgcctcaag  44701 gtatatttta aaagcccttg ctaatcccaa aggaattgtt ctaaaaattt gtttaaatga  44761 aatttttata tattttaata tttaaatttt aaataatatt tttaaaaatc ttaggctgaa  44821 ctttcagttt gtaattagca aagtaattat tatttgcccc aagccagctt cctcctattt  44881 cctgaccctc atttgtcttc cctccttata agatgcttaa tgaaagagaa cttgattttt  44941 gttcatttgt ttttgagaca gggtctggct ctgttgccca ggatagagtg cagtggcaca  45001 attgtagctc actgcagcct tgaacctggg ctcaagggat cctcctgcct cagtgtcctg  45061 agtagcbjgg actacaagct catggctaat gagcctggct aatttttaaa ttttttgtag  45121 agatgggggt ctcgctgtat tgoccaggat ggtottgaac toctaggctc aagcagtcct  45181 ccagcttggc ctcccaaagt actgggattg caggtgtgag gaccacgccc agccttgaaa  45241 cttgattgtt atttacatgg tgcacttaag aagcctaatc ttaccttctg acccagggtt  45301 tgcagtcaca gtccttagag tttttgaata aagactgtgc tatttctttt ttttaaaagg  45361 gatttgtttt tatctaattt atttctgcct ttatgtttac tcattattaa ttattcaaaa  45421 taagattggg atcatcattt atgtatgaat aactcaaatt agtttattgt aatacatagt  45481 cctggtgaag aagaacatat tcagttcatg ccttcaattt gcatttatct tgattagtgt  45541 ttaagtgcat ctcatttccc tatgcttctg ttttcatagc ttatataact acactgttag  45601 attttatgca tgatgtaaca ggatacaatc ccatgatata tttccatgat gtcaaagctt  45661 tgaattatgt aaataggaaa catgaagcaa aagcatacta cttattcatt atgcattgct  45721 atgojgcaga cgcacagtca agtgatgcta tttaatctcc ctatctgcat attcttaaag  45781 tgcatatctc tgtgatatcg aagcactcaa gcaatgagta aatttctgca tctggttaat  45841 aaattcagca aacaggagtt catcaacatc tggcatctgc cttattttac tggctttata  45901 tgaataactg atggatggcg acctttgata aatttagtgg ttgcttggaa ttttagtagg  45961 ggtttgatat tgtttgtgtg ctattgtgaa tttaatatgg caatcaactt tctcttggtt  46021 gctttactca tactagaaac cacagcatca accaatcaaa aggcbgttta gcatttggtg  46081 ttatcacata taccctaatt tgcacaactt tccaaaatgt aagtaccaag agagaagaca  46141 catcaataaa atataggaat tataaggaag aggaagaggt ttttaaaagt atattattat  46201 tcagcaaata atggaaactg gtgctcacaa actactaaat taagagggct tttttccttt  46261 aaaaattaat gcaatgatag tgcagaacac caaataaaaa ctgcatagcc aaggctctgg  46321 aaggttgctg gtggctcctg gacatcagtg ggatttcaca tctttctctc tgacatatca  46381 tttgttcatt tccagagaat gcccagctct gtgttttctt aaaaataagt ttagaattct  46441 cataaaggtg gacattattg gcctagcatg agttaatttt ctctacccct ggacctggac  46501 caatcatata tataagcaga gagcagaaag gtagcacaga ctgaggcaag gtgaggataa  46561 ggtatttttt gbitgtcaca gagacacctt gcttgtctca tttttgaaaa tgatgaaaac  46621 aaatggtgac taataaatag aaaatgctct gtggtattat cttctagtac taatgttttc  46681 ttcactgtcc ctggcctggt atctttcttg gcatacctca caaattactt gacttctgtt  46741 ttatgttgac ttcactcctt tacattacat tattgggaag ccctaggtct tagaaaacta  46801 tttcttaaac tgaattaaaa ttttgccctt gtacactggt actggctctg tcctctcagt  46861 aatagaaaag aagtcttcca tatgtccaca gccattattt gcaaaaagat atctctttct  46921 tcaggcttat gtttcccatg ctacatctct cttgttctct gaaccacact ttatacagcc  46981 tgactttcca tattctcact gttgctgtca tccccatctg atcattcccc tctgtcttaa  47041 aatgtgacaa ttacaactgg acataatact ccatctgtga tcttctcagg acagacccaa  47101 gcaggtccca gtatagtgtt agcaggacat cacatttttg gcttcagatg aacctgtaaa  47161 tacctaaagt acctggactt ttcccatgaa ttgttggtag gccaggatgt gtgccccatt  47221 agttggggac actttctagt gacagttcct ggaactctat ctggctattt ctctagtcag  47281 gcagtgaagg cagataaatc ctoggttcct ggcaggttca ggtggaacac gcagcacagt  47341 gtgcgctgtt gaatgagtgt tcccgagatc taatcacatg gaatgcctga ttgtcaaatg  47401 atgaacaaat aattcaggag atggacctgg gagttgaaaa tttttttaac aaaaaagaaa  47461 ttacatatat gcatttttaa caaaagtttt ataatcattg atatagtgat ggtagcacca  47521 gtagatattc aggcaagtaa ttatcaactg gatgacttat aaaggaattg ataaagcctc  47581 ccaagggatt caagaaaagg gtaaagcttg gaagtcccta aggataagtg gctgagatgt  47641 ttgattcagg acttcctgtc cttgaaacct tggtcagtta ctagcacgta ggacagtctc  47701 tattgtggac cagtaaaaag ctggttgtct ggagaattca gacagaaaag gtaaggctgg  47761 gacccagtta tcaaggctgc actacaacta gggcttgtaa aagttagggg attttggaat  47821 tagcgtagaa ataatgtaat atggtgtaag taacacaggc tttgtaatta gtgcaaaaat  47881 cataagcata tgggcttgag tcagtcttct ctttcctact tactggctgc ataccttttg  47941 tcagctattt aacctctctc taagcctcag cttcttcatt tataaaacaa attaatatta  48001 tctacactga agtattatag gagagatgat aatgtatttt ttaaaaacta gcacagaccc  48061 tggtcaacaa taataaacat actaataatt gttactatta taataaacgt gttgatatct  48121 ttttcttcat caatgacttt ataaaaatat tgggatggag atgccaaaat ctcctctgct  48181 aaatgccatc tttcatccta aggctataca ggaacaggcc ttgcctactg aactttgtag  48241 ctataggcct actacattgc ctcccacttg aaccctoggt tataaacgga atggagagtt  48301 acttttccat tcagaaaaga accttgatat ttcagaagga aaagttagcc ctggacactt  48361 gagcatttct aagaaaatag gttttttttt tctttttaaa ttgtgtacct gctgccctga  48421 attctctaga tgttctgagc actctgtata ttcttactca tagcttagta ataaattatg  48481 tttataaatt ggagactggt attgtataat ttagttcatt gaaataattt gatctggtga  48541 cttcatagcc agacagagtc aatggattca tataaatgag aatccagggt taatcaccat  48601 caaacatttt caacataaag tgacattttt ttccttagaa tgggattttt actacattca  48661 aattttacta atgctgtaaa catgaaaatt ttgagtcagg taatgaattt gagaatggat  48721 agctaatctt taaaaatcta gtaacaaatg tttctgggaa ttgtggctat tgttcccttt  48781 tggaatgatg accaacattt ttggaaatga aaatattgat aaatttgtgt ggacttaaat  48841 atggagtcca cacaagattg gggtcatagg acagaaacaa tatttgtttc acatttacat  48901 tgctgaggta ttatgaagag gttagaaagg tgatttttat ttagcttgca gaataaatat  48961 tttaaaatca cagaataaca tatactatta aatgcctaca tacatttata tccatatgaa  49021 taaaacagta gaagctgaaa tataaaataa catgccactg ctgctggaga gatttaagcc  49081 aattatctgc tatcctggag catcagacat atatatctat atctatctat aatattatat  49141 atttcataat ttatatattt atatatcggt ataatatatt gttttataca gattatatta  49201 ttatatgctg tttttcacca abittgttta catatattat acattattta tatccggtga  49261 ctacataatt gtgcatggta catcccgtct ctagtcagtt gtcatgacaa gagttttaat  49321 catttatgct tactttatga ttctattgta caatttttat tggacattat ttcagttttt  49381 attaattaac agggcatatc aaatacctcc atacacactt tattacagat ttttttgtcc  49441 caaatatttt tagcattttt ttaaatatga aaatagatag tttggaaaca agcttctatc  49501 atctactatt tcttcagtta tttgaatgca gatggcctat cacaggacac aagaagttga  49561 gaatgtgcta ggagaattgc cagcactgct caatacaggt gtttgcccag gtctaccttt  49621 tgactotctc acttgatctg ttottgtgct tctcactttc ctgggcagcc agtcccttac  49681 tgagtatttc tggccttcag tatctgcttc ttccggttcc tttgatgcag cacccacttg  49741 ggctcgcttc tgtagttcgc taaactcagt tgcttatcat tgtaatattt ccgtaatatc  49801 agaatgacta ctgtctcaac ttaggagaca tccacttgtc ttctccagca cctgactgag  49861 ttcttgccat ataaattttt gttgaataaa ttcaatgttt ggcttttcac atcatcataa  49921 acaagactta caccaacaat catgggggaa tttgaataaa attaagatta ggtctgactt  49981 ttgcaatttt acaacttaca agttagtgtt aagaaaatgt ataaagatgg tgatatgcca  50041 ttttgaaaca tattaagcat tttcatcttt agaacagcct tcaagagagt tattatgaaa  50101 cacatttaag cttaagaaag ctgagaatca gaatgataat taataattat ttgagggtgg  50161 atgaaaaagt aaagaacatt tacacagttt tagtgagaat gtaaattagt tcaatcctaa  50221 ggaaaacaat atgaaaattt ctcaaagaac taaaaataga actacagttt gacccagcaa  50281 ccccattact ggtatgoggg tggtactata taagaggaaa agaaacatcc tgtcaaacag  50341 acatctgcac tcatgtttat cgcagcacta tttttaatag caaagtcatg gaatcagcct  50401 aagttcctat cagojgggga ctggatacag aaaatgtggt acatacacac catggaatac  50461 tatgcgtccg taaaaggatg aaatgatgtg ctttgcagca acatggactc tgctggaggc  50521 cgttttccta agtgaattaa cacagaaaca gaaaatcaaa tacttcatgt tctcacttat  50581 acgggagcta aacagtggtc atgtaagcac ataaagatgg aaacagtaga cactggggac  50641 tccaaaatgg ggggaaagag ggaggagaac aagggttgta gaagccaaat tgaagcctga  50701 aacaatacac ctttgtaacc cacctgcaca tgtggcccct gaatctaaaa taaatcaaac  50761 aaaaaattaa caagcaaaca aaaaacagag gaactagggt ttgaattaat atttctgatc  50821 tgcatatcgc tattttcctc ttaaattatg tgcttaaata catgaagaag gaggaggaga  50881 aaaaaacaac ttaattagga gacttacttt aataatgtat catttataac ttttcttcca  50941 aaatctggtt acatgtcaag aaactgtata atgtgaatct ctctagttca cctttccttt  51001 cctttatgta gatcttggtt gcaattcaga ttttcttttt tctaatgaac agtacaatca  51061 gtaacagttg caccaaacat ttcaatttgc aatatacatg taatggtttt tcaagtgaag  51121 gttacatttt atcttttttt attatccata gaataatgtg ttttaggatg aaagagacac  51181 tgtgtgtgtg tactccgttt aaaattaaga tctgacggtc tgagacatca catacaaagc  51241 ataattcagt agctatctga cagtttccca attgctatga cactaaaaat aaaccaaacc  51301 agataaatca accccctaag tggactctct ggcctgaaat gttojggttt taatgtgcct  51361 gtggaatgtt ccaatataat tttcatcaat gttgattgtc cagctcacac agccctgggc  51421 actagagtga ttgacataa ccccgtcatt attccaacaa ttaaatcagc  aggaattagc  51481 acaaacattt ttttcctgtt ccgtacacta aaaatgtttc catgctgcaa tgttaggatt  51541 taaatgtaac aaacataatc ttccctgtgt tgtataactt tccgatctac taagaaagcc  51601 taccaaaatg gagcatttgg tttaaaaata aatacctgga ctcttccatg tggcaacaaa  51661 caatacataa gagatattgg acaatgaaca attaattaca ttgataaaaa taattgatga  51721 attaagaatg taaatctaaa gatactttat attcctcttt ttggtttaac tttcaaatcc  51781 agaaagctct taacctggtt aactaatcga tgataacgtt atacaacaaa cttttgttga  51841 gtacttgcta ttcattcctt gaacgttatt tattgtaata aacgtgttaa ttgaggttct  51901 acatatataa aactgtttaa ggtgcaatga aacaaaaatc acctgaactt cggacaaatg  51961 tgatttttgt ctttgcttag gacgtttttg gaatatttac ttttgaaaat gtctccatga  52021 cctgtggcag tgttttcttc tgaatagtat aaatgacgat ggcaaatcta aaataagtta  52081 tttggagcca catctagaaa ataatgtgag tattccagtt attagggaag gctagatttg  52141 atcaaatata tatatagtta tatgtattct ctctctatat atagaatata tagttacata  52201 tgttctatat atagttatat atactctcta tatatagaat atatagttat atatactctc  52261 tatatataga atatatagtt atatatactc tatatactct atatagaata tatatataac  52321 tatatataga atatatataa ctatatataa atatatagtt atatataact atatatagaa  52381 tatatataac tatatataaa tatatagtta tatatattta tttataaata tagttatata  52441 tactctatat agatatatac tctatataga gaatatatag ttatatatat tctatatata  52501 tattctatat atagttatat attctatata tagatatata ttctatatat agaatatata  52561 gttatatata gttatatata ttctatatat ataacttcta tatatagtta tatattctat  52621 atatagaata tatatataga atatatgtat agaatatata gaatatataa tatatagtta  52681 tatatattct atatatcgaa tagttatata tattcgatat atcgaatata tagttatata  52741 tattcgatat atcgaatata tagttatata tattcgatat atcgaatata tagttatata  52801 tattctatag ccataatgcc tattagcctg gcatttagac ttgcaagtgt caacttatta  52861 cttaccttgt tttattttat ttctttaatg atctcaaaac cttcctctct cgatttcaat  52921 ctgtggtttg ttcccaccat ttgccgaggt ctagcatctt attctttgat tttctttttt  52981 cttttcttca acttttaagt tcaggggttc atgtgcagga tgtgtaggtt tgttacgtag  53041 gtaaatgtgt gccatggtgg tttgctgcac agatcatcct atcacatagg tattaaaccc  53101 agcatccatt aactattctt ccgatgcgtt ccctaccctc atacgctccc cccacaacag  53161 gccccagtgt gtgttgttcc ctcccatgtg tgcatgtgtt ctcatcattc agctcccact  53221 tataagtgag aacatgcagt gtttgctttt ctgctcctgc attagtttgc tcaggatgat  53281 ggcttccagc tccatccatg tccctacaaa ggacatgatc tcgttccttt ttatggctac  53341 atagttttcc atagtgtata tgtaccacat tctctttatc cagtctatca ttgatgggca  53401 atgattttgt aatataatga tttatattcc tttgggtata tacccagtaa tgggattgca  53461 gggtcaagtg gtatttctgc ctctaggtat ttggggaatc accacactgt ctttcagaat  53521 ggttaaacta attaatactc ccacaaacag tgtaaagggt tcctttttct ccacaacacc  53581 accagcatgt gttgtttttt gacttcttaa taatagccat tctgattgga ataagatggt  53641 atctcattgt ggttttgatt ttgcatttct ctaatgatca gtgatattga gcttttattt  53701 catatgtttg tcagctgcat gtatgtcttc ttttgagagg cagaaatacc attcgaccct  53761 gcaatcccat tactgggtat atacccaaag gaatataaat cattatatta taaaatcatt  53821 gcccatcaat gatagactgg ataaagagtc tctgttcatg ttctttgccc actttttaat  53881 gggatttttt tttcttgtaa atttaagttc cttgtagact ctggatatta gacttttgtc  53941 agatggatag attgcagaag ttttctccca ttctgtaggt tgtctgttaa ctccgatgat  54001 agtttctttt gctgtgaaga agctctttag tttaattaga tcccattcgt caatctttgc  54061 ttttgttgca atcgcttttg gcgtcttcgt catgaaatct ttgcctatgc ctgtgtcctc  54121 aatggtattg cctagattat cttctaggat ttttgtagtt ttgagtttta catttaaatc  54181 tttaatccat cttgagttaa tttttgcata tgatgtaagg aaagggtcaa gtttcaattt  54241 tctgcatgtg gctagccagt tctcccagca ccatttatta aatagggagt cctttctcta  54301 ttgtttattt ttgtcaggtt tgtcaaaagt cagatggttg taggtgtgtg gctttattcc  54361 tgggttctct gttctgttcc attggtctat gtgtctcttc ttgtaccagt atcctgctgt  54421 tttggttact gttgacttgt agtatagttt gaaatcaggt agtgtgatgc ctccagcttt  54481 gtgctttttg cttaggattg tcttggctat ctgggctctt ttttgattcc atatgaattt  54541 tttaaaagtt tttctaatgc tgtgaagaat accaatggta gtttaatgga aatagcattg  54601 aatctatcaa ttactttggg cagtatggcc attttcatga tattgattct tcctatccat  54661 gagcatgaaa tgcttttcca tttgcttgtg tcctctctga attttttatc agtggtttgt  54721 acttctcctt gaagaggtct ttcacttccc ttgttagctg tattagcatc ttattctttc  54781 aagaggacag tttgttcagt ttgtttaaat tattatcacc atcacaacca ttaaaccttt  54841 attcagcaac tgaagaatgt accacaatat ctctcatttg caagacatat tctgttcatc  54901 ttctgctttc tgcttctgta gcttataaag atatataaat atattttaaa cccaatttgt  54961 aattatatat gatgggaatt gaaaacgtgg gtgattttca aataatcact aaggaataaa  55021 atatgctaaa aataaattgt gaagaattga tatgattttc taaggatggc tttactggag  55081 aaaagcagtt atcctacaat agttaatata taactatttt tatgattatt ctgttcagaa  55141 tctgaattta tattattatt tggggccttt tttaatcaag tgaagaaagg tatattttct  55201 tttcaaactt tttattttga acattcataa attacatgaa cactaaaaga cataaattat  55261 ctttcaggaa acattgaata aattctggat tcttctatat tttattgatt tgtaaaacat  55321 ctcaaattta acatagaaat gttaaaaaga gattatatta taacgtttgt tggaaaatat  55381 gctatattta taatatttat tctgtattta tatattataa atatattcta tatttatata  55441 ttataaacat attctatata tattataaac atattctata tttattaaca tttaacatta  55501 atgttaataa atatagaata tttttcaaca aactttataa tataattccc tccttcaatg  55561 aactaatttt tatggtggtt tacatttctt tttcaatgtt ggtttacatt tgacgttagg  55621 atgtttatta gttaatacaa taaagtgggt ggtcttttca ttaatattat cagtcaggtt  55681 tgtaaatagt gtatgttttg tataaccact taaaatttat atactgatat atattttgtt  55741 taagaatact taaaataaaa acattagtta tcatttgttg aactggaagg atcattactt  55801 aaaaatccat ccttaaaatt aaaatgactt atgcttcact gtgtagtgca ttgataaata  55861 tttagtctat agttttttct attgctatgt gtttagccaa gaattgtttt taatttggtg  55921 aacagtacct tattaggaat atgaaaattt ttgaagcagt catgaaatat ttaacaatta  55981 attatttaac aaacaattat gcaaaattaa ttttactaaa gaaatatttt taaatcactg  56041 caagaaatat tttcattcaa atgagtactt acaaccaaga aagagtcttt tattttttaa  56101 atgtgtataa atttaaactt caaaatactt aaatcactta atgcctcaga gaaaatatct  56161 taatacttat gaagtgttac gtgtactaag cattatgtta aattctataa agacatcttt  56221 ttaaatcatc acaagaaatt acaaggcagg tgcatctatt atatttttta tagtagaact  56281 aattgaggca cagtgagagg aaatgatgta ctcaagttcc acaggtgata agtggtacag  56341 ctgagtaaaa ttccaagtct aaaagctagt ctcttaacta ttatatatcg gcctatatgc  56401 ataggccgac aagtagttat ttaaagttat ataaatcaag agaaaacact acaaaattta  56461 cctataggat atttatacaa aatatgggca ttttattagg aaagotttct agaaatatgg  56521 gggaacttta agaaacagtg aaattcaaag ctatcattgt ccaaaagcat gtggtcttct  56581 gtttttgcac tagtgactta ggtgcaaatt acttccaaga tttttctcct aattgagaag  56641 tactttttag gtctagattc catggaggag gtgggtcttc gaggtggggc ttcaaggtgg  56701 agatagtgtc ttttttctag catgtaatga ggtaaatttg cttttgaatg aacaggtgca  56761 cctatttcaa ttaaggcaaa ttagtttcca aaggctttgc tatttaagat attatagaag  56821 gctatttaaa tgtgccaatt tacataaaat acattttgaa agattacagg aaacaatttt  56881 atataattca ctgaaacaat ttcacagtcc tctcaaatga tgattttgaa aatgacctaa  56941 atggcaggca cctctttgaa gcagctggca tgatgttatg tggtcccatg gccccttaca  57001 ttttcaggtc aatggtaaat tctccagagt ccaacttcaa ccctgcagta ttctgttcaa  57061 aattgcccct gttcagaagc ctgcatatgt aacctcttac attttgtgtt tcacaatttc  57121 cattgaactc ttcctacaca ccagaatggg caaaaatagg aatttaattt ctgggaagat  57181 ttcctctaag agcctctgtc caaaacatcc agtgctgaaa caagaaaagg tggtcctggc  57241 atatatccac tagtaatttt tttgtcttct tcttttcttt cctgttttat gtgtgaatag  57301 tgaaacttat cggttcaaag accgatgagt cagaatgctg tcattttaca tccaaacagt  57361 ggaaatttaa attgttaaaa taaaaataca caatcactaa cattaccctg atgaaataat  57421 gataagcaaa gtagtcttaa attacaggct ataagtgctg gataaagaac aatattttaa  57481 aaatatctaa agtcatataa tgaacagaag acagatttcc atttatacct gaaagactgg  57541 ttttcagaaa ttataataga acatggggat ttaaaaattg tatttggatc atttatttta  57601 cagttagaaa gtgatgtagg aaggagttcc cagaggagat gaaacagatt gaaaacagca  57661 aaattccatg acagaggtgg cttgaaatag accctttttt caaagcaata actggcctct  57721 tcatcatcta tagatagcat ttttggcaaa atcagaaaca tttgctttgc cagtcattga  57781 aggtaaaaag aaaaaaaaaa tggctgaatg cttttaaatt acatttattt aatttctgct  57841 ttcatacaaa ggcataaaat tatcagttta aattttaaaa aatattatta taaaattaca  57901 tgcttagaag tctgttgatt gttttcccac agccatttta taactgaaac cctcaatttt  57961 ggatatgaat gtataataaa cgcacatgtt cattctaaac attttctttt caaatacttt  58021 tacattcctt taggtttcct aaagaaatgt aaattccttc tgccacttag tttttgctat  58081 ttttagcagt ttcttaaagt ctgcaaattc ctttcactca gtttttgcac ttagttcata  58141 atgacttcac atttgacatt gattgtccac aaaaggggtt atttttagtt tcaaaaggtg  58201 aacgttattt gttttagaaa ttctcgcgta tatttcttag tctaaagata ggttttctaa  58261 cataaaaatg tgatagtgta gtctgtttgc tgagcacttg tagtggaaca aactcagtgc  58321 taaattcttg gtttttaata actaatttat ttattacagt aactgctaaa tatgcttcaa  58381 attataaact atttgccaaa attacagata ataatataac caaacaccat gtggatttca  58441 cctaaactag aagtaacttg gtgactttct tatttaatct tttatttatt gtacttggcc  58501 atacttattg tatgtttatg tataaaaaca taaagcaata gaagttttta cagttattat  58561 actcactgtc ttataaatgg agaaactgag acccagagaa ttttagtaac ttattcaaag  58621 ttacctagct ggtgactaga agcaaaacac aaataagacc acagattact agttttgtca  58681 agatcttcaa cataatttaa tattgcbgtc aactcagagg tctcagaaga taaggtctta  58741 ccatctgaaa acaacaaaaa agaaatttca taaaatcctg tttgtaccaa gcaatttatt  58801 tctagaatga aagcaaaatt atttttttaa agttctttag attgctgaga aatcaagagc  58861 attagggttg tgtctcccct ttaaatttac cttttagttt ctttgggttt aagtttttag  58921 atgaaatttt aaattctatt tagctctcag tttatgtgta tttaaaattt agatttagga  58981 tctattcttt ttaataaggg tgaaattaca tatggagaaa tttactgttt atagcgagtt  59041 ttgacaacta gagttgtata accaccatcc ccacagtcaa gatacatcac ttctcccctt  59101 cccaaacata ttccctggtg acactttgtg gtcatactca ttctccgcct ctagcctttt  59161 acaatgactt ctgttactcc ccctgtagat ttgcctatta aagaatgtta tataaaggaa  59221 tcacacatca tgtagcattt tgaatctggc ttgctttact tgttttaatg catttgagat  59281 ttgttcctat tgtggcagat atcagtagta gtcttctttt cattgttgga tattccatta  59341 catgaatgta caatcacatt ttatccattt gcccagctaa agaacatttg ggtgttttca  59401 gttttcatta ttatgagtaa accctccata aacatattgc atacaaattt ttatgtgaac  59461 ataagttttt gtttcaccta aacagatact atacaggact gaaattttag taagtatatg  59521 tttaactttg tgagaaactg cccaactgtt tttgcaaagt ggctgtacag atttacattt  59581 tcaacagcaa catgtgagag ttccagttgc tgcacgtcct tgtgagcact tagggttgta  59641 tttttaattt tatccactct aatgggtgtg gagtggtgtc ttattaaggt tttaataagc  59701 atttctctaa tttaatgcat tatattactt ctttttgttg gtttgtaaac tgcttatctt  59761 ctttggtgag tttgatcaaa tcatttgtcc abitttgtgt ttttgattat atttcagata  59821 caagtcttta ccagttatgt gctttgtaaa tgttttctca ctgtttatca tttgtgtgtt  59881 ttatggaaag cagaatattt cgattttctg gaaatataat ttgtcacttt aaaaattatg  59941 taaattgcta ttggtattaa gtgtaagaaa actttgcttc atctatgatc acaaatattt  60001 tcttctgaaa aaaaagctct ctgaagagtt tttttttttc aatgaatgtg ttttctttct  60061 tctctccata tgttatcttc tgaatagcta agcaatgttt acattattta ttcaggcctt  60121 tccatccact ttcacggatt ccactgaagg agaaattggg tttgaaatcc tcttttctca  60181 aaaactaatg agtcatgcat cttctcattg atattatctg gctcccctga aaacctctag  60241 tttggtccat ttttagtgat atctttctac tcaggttcct caaaccaatc tgtacctaag  60301 agacccccag attaaaattc aagttcattc ttttaacaaa ttaggtgcta attgctacaa  60361 atgcaagaaa acttcaggtg ctaatttgtt aaaagaatga acttgaactt tagtctgggg  60421 gtctcttaga tatagattga aaaggattga aaagaattat agtttctttc acttttgcca  60481 tcatacaata tgtattattt atatttcttc ttcgttaata ttcagttcac cttctttgtc  60541 catctttcta ttgaagcacc agtattcatg cagtgtttta agaatattag tccattttta  60601 tccattatgt atattgcaaa taatttcgta ctttattgtc ttttaatttg tttgcagtgt  60661 cctaagagta taaatataat agcttttcta cttttttcat tttttaatat tgcattttct  60781 ctattgtgaa tgttatgctt atgtttttct ccagctgatc tattgaggaa cagtgttttt  60841 ttaataaata taaatattgt tatagttatt tctcatttcg aagttttacg gtactaattt  60901 gtctgtctta aaacttcaaa taatacttaa ttgaaagtct ctgtctacca tcatcccttt  60961 cttaacagtt cggtgaatat cttttattat attgtgtaag gatgttgtat tgcagctcct  61021 cttgctaggc tgaacatgca gacctgttct ggaaatagat gtgatcagtt taggtcacaa  61081 cctgtcttga atcacagctg acttgtagtg gagagttcca ggaaccttcc aatcacacac  61141 aggtccctat tgctcctttt cttctagggc tattcaacaa gcagagacaa acaaaaactg  61201 atctgtcaca ttttactgca ggtaacagtg accacaaata cacctgtaca ctgttttttt  61261 tccaacatta ttgaggtgtg actgacaaat aaaaatggta tatatttaag gtatgtgatg  61321 cgatgttttg ctgtacatgt acattgtgaa atgattatca taatcatgtt aacatatcca  61381 tcacctcaca tattgttatt tttataatca cttttataaa ttttcccttc agtagtaacc  61441 ttttgagatt ctgaaacact tttgagtttt gaatgttgtg tcataagtga gtttttttgg  61501 caaatatttt ataaacatct aattgggaaa ctgtgagagg atgttttgta actttcattt  61561 aaactaagat ctcctctcca cctccaccct tcccatattc agtagatttt ctatggctgt  61621 atggtgtatc aggaatcatc ccatatactt cagaaagtaa tggaataata taaatatttt  61681 tctaacatag acctacagag attaagtgat atactcaaat cataccataa atggtagtga  61741 aagggtaaac tcaacattca cagccaactt cattatctaa tagggaacaa cacatttcat  61801 attaataatt gacttttatt tttaggaggc tctgttataa tgaaattaaa aaatgagatt  61861 agattatgtt tctcaatata tggtacaaaa atcacttaca tagaataact tcgattatta  61921 aaaatagaag tgaaaaatac ttttcagatt aaataagatt tcaattttaa ggcaaatatg  61981 ttcattttgt gctcaaaaat tagacaggaa aactataatc tgttaaaatg taggttcttg  62041 atccacccaa gaaaccatgg agaggtgggg gacagttacc tgcatttctg acagttagtt  62101 cattgactct tattcgacta aactttgaga accagtgtcc aaagtattta cttacatatt  62161 tatatttaaa agctgggata atcatgacaa tataaaataa acaattgatg ttgtatttta  62221 cttggcagat agataaagct atacaagttt cctttttcct aattctaaag cataattaga  62281 aaaaaattgt atttatttct tagatatggt aactactaaa atataatttg gaatgttcta  62341 cttaaatgag tatacttatg tatgcagtta gccgtcaata agatttagtg ttctctgaac  62401 tatttcattt ctatgaaggt ggtattaatc ttgatgataa aattttcttt taaatattga  62461 gagattctgc caaaatataa atcttactgt gacaatgttg ttgaaattcc tttcttcata  62521 tgattatttg ttctaaaata gctcccatga aagtaaaatt cctactctca agcatcctgc  62581 ttaagcatat tgtattgttg ctggtaacta aaaataaagc aaagcattag ggtggatttc  62641 agtgtaattt tatctgttta gtagagtgat acaaatgaat aaattttcaa acatacaaat  62701 tgaccaatta tttgaaagag ctatgaataa aataaataag ctaccttaaa attattttaa  62761 aattatatca caaaattttt ttcctaacaa caaaatatgt atttttaatt gttttggttc  62821 atacaaatta aaatacaaat ataattttac caaggaaagt gaagtaattt aggagtaatt  62881 aataatattt gtgttaggga acggagcata gatactatta aacctaaccg ttttatagtg  62941 catttgtttc taaatccctt aagctggtaa gtcattgatc ttgcattttt ctttgacagg  63001 cttatgcaag caaagatctg gaggagcagt tacggtctgt gtccagtgta gatgaactca  63061 tgactgtact ctacccagaa tattggaaaa tgtacaagtg tcagctaagg aaaggaggct  63121 ggcaacataa cagagaacag gccaacctca actcaaggac agaagagact ataaaatttg  63181 ctgcagcaca ttataataca gagatcttga aaagtaagta tgggaaataa aatgtatagt  63241 aagccttata tatcaaacca gtagaagttg ccagcctggt tctttaattt cagtgtttgt  63301 atcaccgaat acacctttag ggcggaaagc aaatagaaaa taaagaatta cttcaaaata  63361 caacatttta tgatttcact ttgagtatta agatgacttc ataaaataca ggatagatag  63421 gtccatgcat aaacaacaca catttatttt ttcaggtgat agccattgga aaatttttaa  63481 aacagatggc tatattttac atactatatc tgtttaataa cttaaacatt ctttatctta  63541 tcaaataatt ataccttaat ttcctatctg atttggattg agaaatgctt catttgaaat  63601 caccttttca gatgtcactt gttgctttgc tgcttcacag ataactggct cagagcggga  63661 cttaagctga tgaggtatct agcataaagc ttcacaaaaa atgatcatgt tgcataaaat  63721 gtcatagcat caattggtgg ggtatgactg ggcacagagg ttcatgtctg taatccgaga  63781 ccattgggag gccaaagtgg gaggattgct tgaagccaga gtcagagacc agcctgaaca  63841 acacagcaag acctcatctc tattaaaaaa aattaaaaag tggtggagta atttaaaaac  63901 atatttgcct tcagttggta gctcttaatc gctataaaag tttgatattg gaaagtattt  63961 tgagaacaga ggcaaacaaa atggcttcat ggttgtataa ccaatagttt atgtcctttt  64021 ccaaaaattc tattttaggg gaaatatggg ataagtaaac tagtatactt aggaagtaca  64081 ttatttgtaa tgcagaattt aaaaagtcaa cagtattata ggtaagctac taactcatca  64141 gaaacaaaat tccagaggag agttaaaagg gataggaaat attgactttg ctgaagaaag  64201 ttcagaatga gtcccagttg gtgaaaaata gccttgtatt ttatgtagct gcagccacga  64261 cattactcaa ggttgccaaa tagtccgcct gaaaaggacg tttgacttga atctaaaacc  64321 atagcbgtct tctcatatgc aactcagttt taaagaaaaa taaaattata tttatatttg  64381 cattgagagc acaaaaatgg cccatactat agagaatgaa catgactctc tctgcacatc  64441 ttataaacat tcatatatta aattaccatt ttcctaagaa agaaaaacca aacattagtg  64501 ttgtgggata ttggtgtact tttaataaag cataatgcta atttttctta ttgcctagct  64561 atagaaatga gtttaagaaa tatccttagc ttgtcttttc aatgttatat cattctcatt  64621 cacaagtcaa tttaggatcc catcagctgt ctctttagtt atatattgaa cttaaatgtt  64681 aaaatctgaa atgaatgtga gtgatttgca gctgcbgtgg gcttttttta tcttggtggt  64741 ttccgtaaaa cttactgatt tccctatgac ttgacaggta ttgataatga gtggagaaag  64801 actcaatgca tgccacggga ggtgtgtata gatgtgggga aggagtttgg agtcgcgaca  64861 aacaccttct ttaaacctcc atgtgtgtcc gtctacagat gtgggggttg ctgcaatagt  64921 gaggggctgc agtgcatgaa caccagcacg agctacctca gcaagacggt gggtattgcc  64981 cattcctgct acctgcgaga gcccccttaa tcagaagctt taactttggg gatgatgtgt  65041 ttaaacttct ggttgcttta aactaacttg gttcaactca gggtctcata ttttctttag  65101 gggaatgaag tcagtttttc agtgttttgt gtgtttgaca acacagtgtc acaaagaaag  65161 taattgatgc tttattactt tgcaaactct tcatatagtg gagtcaaagc ctcatgcaga  65221 aaacaataaa tatacgtatg tatgtgtgta catgtacgtg tgtatgtgtg tgtgttgatc  65281 ttcaagaata aacatgttca tttggcaata aaatactttt aaatgggtga gttttcagat  65341 ggtggagata acagtgcaaa cagtattcaa agtgtaaaat taaatgcgtg tgttctgtga  65401 aacagtggta tagtattgaa ataagccatc tcactgaaga aatttattgt cttcctgtcg  65461 aaagcaaagg aaataactct gacactaaat ctcagatgtt ttgaataaac tgggaagttt  65521 atctcattaa atggtaagct tctgataacc aggaaatgtc tcttaaggtt ggctttggat  65581 cagggatttt cagaccagac acataaaccc gotttgtggg cottacgtgg tagaggaggc  65641 tggcbgtgga acacgcgtat gtgctggcga taaccatgaa agtgttgttt gaaattgtgt  65701 gcacctctgg cctctgaaca gaaatgtttg gagaaatcca gtcccgtggg ctggactgaa  65761 gcaaacttct cccgaaagac aaaactgtgg ttgtcctaat gacctttcta agctattttt  65821 ggagttagac tcacacacgt aaatctggct aaattcagaa ctgttctttg acctggagaa  65881 tgaaaaatga aattgaaaga tgtggtgtta gatttgattt gtatgatgtg gtatgacaga  65941 aaattcacat tttaatttta tgcaaacttt agctgatcta catggttttc agtaataaaa  66001 cctactctta tttcaatata gtattaatag aaatcagagt taagattact atctcaattc  66061 catgaactac attttttcag ctagctgaat atttccaaaa tttttactgt tacgatcatt  66121 tggcctctga gtttggagac attgtcttat tatacaaccc aaattaattg ctttcttttc  66181 aaaaattgag tttctttata ttgctcaccc acttgataaa gaaacaagcc attttagatt  66241 aagacttgca agaagaaaca aaaaataaat tataaagcta aattttctat tcagcttgcc  66301 tctgcctcaa ctctaaaggt taaaaaaaat taaaaggtga tgctttgggg cctgctatca  66361 tttcttttag tatcatagtt agttaagctt agccagatgc aattcattct gattatttcc  66421 taaaagcaca gcaaaataat gtaggggtcg ttccaacatg tgttctcaag gaatacaatg  66481 tgactctaaa catagtcctg catttagaaa ctttaccaga aaaatgtaca gttgtaggaa  66541 catgacaata tttcagtggt tgccaaaatt ataatatttt tgatagacta acatataatt  66601 atactattgg acatagcaaa agttatcctt agttcattta tcctccctga gtctttatca  66661 aacaacaata aacaataaga cgttatagtt ttgtacttac tattctaaat aaattaatac  66721 tactttaaca ggttttattg gtattatgta ttttatcata accctgaaat caaacaggat  66781 tctttaagat cctctaaatt ttagaactgc atactttaaa ataaattaaa tagaaatact  66841 taggccaagc agatattctt tgaaaggtaa tattcatttt taaaacatat taataattaa  66901 aabittgttt ttatcttcaa gccaaacctc ttaatgggaa ttttggtata ctgagtctct  66961 tgagaaatat gtcatttcct tttaaagtta gagaaaataa atatggatga tttaggaatt  67021 gaaatataca atttttggaa tgccgttaat gatttatatt ttaaaataat tcagttaagc  67081 aatatgatgt attctagatt atattcctaa tatggtattt gatttaaatc aaatagtaaa  67141 ccaaggtact ttggatactg tttccaacta ataagataac cttctctctg ctcttcctcc  67201 ttccatttcc tttcttcata atcttttcta taaattactt tcaagcatat tttttaaaaa  67261 catagatcca aatctatggc taggcatggt ggctcacgcc tgtggtctca gctgctgagg  67321 aggcagaggc aggaggatcg ctggagccca ggagttcagg gctgcagtgt gctaggattg  67381 caccactgca ctcccagcct aggtgacaga gcatgaccct gtttcaaaaa caaaaaaacc  67441 ccacagagct gatgtcagtc tccagcataa aggcctttca gtgatttccc attgcttgta  67501 aaataagaca aaaatctttt ttgaaggtta tatttattga catatcatag ctgtacatat  67561 tttggggtca tgtgttatat gttgatacct gtacaaaatg tgtaatgatc aaatcagggt  67621 aattgggata tccatcatct caaacattta tcttttcttt ctattgggaa caatacagta  67681 cttctcttgc agctttttaa aaaatataca atatatcgtt attcactcca atttccctga  67741 tgtactattg aacactaaaa cttactcctt ctatttaact gtgcttttgt acccctcaac  67801 catcctctct ccatcctccc tacccttgcc cctcccagcc tctgataatc agtattcttc  67861 totctacttc catgagatcc actcgtttag ctcccacata aatgagaaca tgcaggattt  67921 tcaagaccac atctttatca caacctgcaa tctctgcccc atagcccctg ttcagcatca  67981 tctaatgtaa tgattcttga tcttgtgctt ccagtgctct agactttctc caattcctgg  68041 gcatcatcgt gtttcctctg ctcctgggcc cttgcacaca cacctttagg ttaacctggc  68101 cttcctgtct cctctttcct gaggtgctag ctcttcagat cttaatttgg gtgtcaagtg  68161 gctttggcaa ggcctcaggc aagactttct gacctatttg gattagaccc aatatttgta  68221 gtaaatgctt tatagtttcc catattttta aaatagtatt tattacagcc tataatcaca  68281 tagtttatag ttatgtagtc attgttactt gattaatgtc tccctcctcc acaaaggcaa  68341 aaacagatcc gttcactact tatcccagtg cctaccacag aatcagtgca caaatctctt  68401 ttagtatcac ataaaaactg tggacccttt catgagaaca aatgaaaata tagacacatc  68461 cacagcattt ccccccacag ttttagggag tttgttccct gacccctagc cttttccctt  68521 taaaccaggc tttaaaactg ctgccttgaa gattattaat aataaaatag ctgattaaca  68581 cacttgtgga attttcaaat aattggtctt tttgctaaac aaacgtttat gctatcaatt  68641 tagcttgatc ttttaaaaaa tatctgtttc tggagaggaa cagaaaaggt aactattggg  68701 tactgggctt aattcctggg tgatgaaata atctgtgcaa caacccccat gacatgagtt  68761 tacctatgtc acaaacctgc acatgcaccc ccaaacctaa aataaaagtt tacctattta  68821 acaaacctgc acatggaccc ccaaacctaa aataaaagtt tacctatgta acaaacctgc  68881 acatggaccc ccaaacctaa aataaaaccc caaacctaaa ataaaagttt atgtcacaaa  68941 cctgcacatg cacccccaaa cctaaaataa aaccccaaac ctaaaataaa agtttaccta  69001 tgtcacaaac ctgcacatgc acccccaaac ctaaaataaa agtttacctg tgtcgcaaat  69061 ctgcatatgc accgcgaaac ctaaaataaa agtttaccta tgtcacaaat ctgcacatgg  69121 acccccaaac ctaaaataaa agtttaccta tgtcacaaac ctgcacatgg acccccaaac  69181 ctaaaataaa accccaaact taaaataaaa gtttacctat gtcacaaacc tgcacatgga  69241 cccacaaacc tgcacatgga cccccaaacc taaaataaaa ccccaaacct aaaataaaag  69301 tttacctatg tcacaaacct gcacatgcac ccccaaacct aaaataaaag tttacgtatg  69361 taacaaacct gcacatggac ccccaaacct aaatataaac tttatatatg tatgtatata  69421 tatacatatg tatatacaga tatacatata tgtatctgta aaagaaacat atctatctat  69481 atctatatct agatatccag atgactagat gagatataga tatctgtttc tcttacagat  69541 aaggaagaaa attcttcttt attctctcat tcattagtta atatgagcaa aagccaacat  69601 tatatctttc ttactattgg tcaaccaaat aaatgcatac tttacatatg ggccaaatag  69661 atacctaagc ataccttagg taaaatctaa acttggaaaa cagaaaatca gtacattgtt  69721 agtaagcaaa gtaaataaat ttagtcttct attaaccatt tgagtttttt ctgtgaccat  69781 tgcatattca ttttctgcat tggtctaatt aggtgtcaca ttcacccagt gggtattgga  69841 gtgaaagtat ttattcaagg gtaggtgtgt atgctcagta gcataaaaat tgctctatca  69901 agagggaggt gttggagagg tttaggcttt agaaattgca aggcttcgct gggcactgtg  69961 gcttacacct gtaatcccag cactttggga tgccaagaca ggcagatctc ttgagcttag  70021 gaattggaga ccagcctggg caacatagtg aaaccctgtc tccccaaaaa agtataaaaa  70081 ttagccaggc atggtgttgt gcacctgtgg tcccagctac gcgggaggta gctgaggtgg  70141 gaggattgct ggatcctgga aggcagaggc tgcagtgagt aaagatcgca gcactgcact  70201 ccagcctggg tgacagagcc agaccctgcc tcaaaaaaaa aaaaaacaaa aaaaaaacaa  70261 aagaaaaaaa ttacaagggg ccaggggtaa gatgagcatt tagtgctaag tgtaagctgc  70321 atataggtga aataattttg cccagtctac ttagtactta aacatcagat atttgctata  70381 agaaaattgt ctactttaga tcacatggaa tcttttcttg ctgtatttca tctctttcac  70441 ctcccagctt tgcagaattt aggcttactt ttataataga tttacaatgt tgatatgagt  70501 tttgtcaact tcttcccaat catttgcttg tgtgaaaaat caggacttgc ccatgaaatt  70561 tctgaagttt gtctgctttt ttgttattgg ttgatttttt tttcagtttt ttttctatcc  70621 tattggtggg ctatatattt acaataatca caatatttat acattctgat ctgtaatgca  70681 gtcatatttt aaaatttata tagcattagt ttttattttg tcattttaat tttttaaaga  70741 tttgaagatt ttgagaatta aaaatttgta gttcatcaaa aatatggtat ttctcctgag  70801 aattctgacc taagacacct tctctgcaga ctgtaactct ccttgtattt tctcatctac  70861 ttttttttac ttttcccaaa cctttccctc caattcaggc ttctttcctg atttctatac  70921 tgtccactca accttgtgac ttggctgtcc ctcagacagg tcagtctgtc tcacttaaca  70981 gttagaacct attccctacc accttgccca aataagcaag taagtgaatc ctattctttt  71041 tccagtgttc bitgtcttag taaatgacat catcattcag ccagtoggtc aagccaagtt  71101 attcttcctt tcaccaaaac taattgctat tcaatctacc ttgcaaacat ctctaggacc  71161 tatccagtgt ctccacgctg ctaatcccgc tctgatctag gtcacattta ccccttacct  71221 agaccattcc tcttggacaa gcctaataac tggtctccta cctccattct tcctttcctc  71281 caatctattt gccacttttt agcagtgatt tttttttctt ttcttaatgc taagtcagat  71341 actgctaaaa actccttgat aacattgcct tattgggatg gagccagcat tcaactagtg  71401 tggtgataag cttatctttt ctaattgggt tgcttaggcc agcatctggt cagattgatt  71461 ggtacaaatg ttctaagttg ttagtgtttt gaatggaact cttctttcag acaaaatccc  71521 ttaaacataa tttcctgggc cctcaatgat ctggatgcta cctaagtgtc cagcctcaaa  71581 tgtcaatgct tttccccaca aacactactt accactaaga cccaaattct tttcacttct  71641 tgggttatgt caatatctgt cacctccagt attgcaatgc tgtactctgt gtttgaaaca  71701 tctccctaca catgatcccg tatctcgatg tatctagtta atgtctactc atccttaggc  71761 ctaaacataa atgtgacttc caggacattc bittatgtgc ttccacagca tccattgttg  71821 ctgtatctta gcatcattac cttatctgtc agattgtttt atctttgttt aattccctag  71881 gttttttttt tttttttttt tttagatgga gtctcactct tgttgcccag gtgggggagt  71941 gcagtggcag gaactcagct cactgtgacc tctgcctcct gggttcaagt gattatcttg  72001 cctcagcctc ccaagtagct gggattgcag gtgtgcacca ccacacctgg ctaatttttt  72061 gtatttgtag tagagatggg gtttcaccat gttagccagg ctggtctaga aactcctgac  72121 ctcaggtgat cctcccacct ctgcctccca aagtgctggg attacaggtg tgagccactg  72181 cacccagtct tattccatag gttctagact ccatgaaaac aaagattgcg tctgcttgtt  72241 acactgaaca atagcacagt agttggcaca tagcaaacac ttagaagtga ataaaatgaa  72301 tatttgaata aaaagaaaca aatttggggt caaaggtcaa attttgaata tgctgatttg  72361 aaagagtctg aatggtgttt aggtggagat accagaaggt ttgatgtaca attctaaaat  72421 tttagaacaa taactgggtc tttaaatata gatttgggag gaagcatcat tctgataaat  72481 gtcatttgaa gcctggtgtg cttattaatt cttagggtat tgatgtatca caagagaaga  72541 gcaaacatca gtaccaaggg aaagccaaca ttcatcatta gcbgtgccct gcatttccct  72601 ctttgatttt gtattatcat gcccttttcc tatccaaagg attcgcttat atttttgttt  72661 atagtataag gaattttttt ttttttgaaa cggagtctca ctcttgtcac ccaggctgga  72721 gtgcaatggt gtgatcttgg ctcactgcaa cctccacctc ctgggttcaa gcgattctcc  72781 tgcctcagcc tcccgagtag ctgggattac aggtgtccac caccacgccc agctgatttt  72841 gtattttaat agagataggt tttcaccacg ttggccaggc tggtctcgaa ctcctgactt  72901 caagtgatcc actcgcctcg gccacccaat gtgctgggat tacaggcatg agccaccgca  72961 ccojgcagat agttttaatt taaattcagt tagacaagtg catgtggtac acccattatg  73021 tgacgcttca tattatgtac taaaagcatg ctatgcacaa agtgtaggtg tacagtgatg  73081 gatagatcct gccctatgga actaacaaat tagcaagcga aatcaacatt tatcaagtaa  73141 ttaaaagtag tttaagtgtt gtgaaggaaa agtacaaagg cttatggaag tgcatatcca  73201 ggatgtttat aaaccaaggg aggtcgaggc ataaaatttc tgaaagcaag aatgcagtgt  73261 tcctacattt ttactaatat tccaagttct gaaaacgtgt acttaagtag cagcttttcc  73321 tgagtttatt caatttattg cattatcagt gtagtatgaa tgggagtgtg tgatgatttc  73381 cttcaaatat aaaaggaaat ttcttaatgc gttgttttct taaggtaaaa aaaaacaaaa  73441 aaaagacttt toittttgtt aaaagagttc caggcacatt ttgtagcaaa gccaccaatt  73501 ggcatgatgt aaattgtaag gacaatgtac cttaggtaat gttaaactca agttttttat  73561 agatacttca tagaaatgct tttttaaaat gggactcaat gaaggggagg ttatcagggc  73621 gtgtgaggaa gccagcbgtt cattgaaaag taaaagcata tgcactgtgc attccaaagt  73681 atactaatgg ataaaaactg cttcaaagtt ctccacacaa gtatctaagt ggctttgaaa  73741 agttaagtag attggatgtc ttttcaacct ctttcataaa catacacttt gagtatattt  73801 tcttatgaga agttgtatgt ttaagagata taaccaaaaa gtagaaaatg aattttgcag  73861 ggggtaaatt atttggtgat gaaagcagaa gcagaagaaa gtcatctgct tttgaggcac  73921 acatttggat taaaagttac ttgaatgtta gtatttacct tatatatttt actaaatcta  73981 ggaaagaata aagaaaaaca gctcaatctc tagagtcttc ctgaaaatgg tggggttaaa  74041 tcaagctcaa ggaactagaa gttctttgct gtgttcatta gtgccagact aaagaagcca  74101 gtttagttaa gaagctagct tgctatgagc taattctgat acatagaagc agcattattt  74161 taaattctac attgccatct taaaaacaag cagctacttc tttttcatta ttttataaag  74221 caataatatg agcaatcaat aatatgagca tgtatattaa caaagacatg ctcgattata  74281 tttaagttgg atgtttcata aaattttaca acaaaaaata tttaaaccta agtaaaatat  74341 gcaactatat aatgaaatta gaggtattat tttgcactgc agtcagagat atttcttcca  74401 ttaattaaac agaatactgc agcagtctgg aagattaatt tattacattc ctttgtattc  74461 agcaagtgga acgtgatttg tattgtatct ttagcaagtt aatatttggc aagcacagtt  74521 tttggaaatc aggttttatc ctgatgtgga aaaagaactc tatgccagta ccagttatca  74581 gaactttctt taagaataac atttgcctta agaacataat taatgcatct gtgaaaaata  74641 ccactttttt ccaacccaag gtacaatgag attcacgtat tttattcagt atttctaaaa  74701 ctcttcaatt gaggttttta ttttaattgt ggtactgtgt atacttttta tgcataacaa  74761 tatgttaaaa ttaattcagt accagattta aatctgttag gctatctgtt attccatttt  74821 ctttcccaaa cccaatttaa gttccacagg ccttttatag ctggccatgt ggttgcaatg  74881 ctaagtcaaa atgctaagac cttttcccat tttggggcat tatttcttta aattcgttgt  74941 agttttaaaa tctgatttta tagttattaa tcatattctt ctgggggtac atatatctgt  75001 acttaatgga ctaaagtttg gaatatttaa atttaaatta aatatggtag tgagatttgt  75061 tctgaagaga aactggttat atttaggata taatggtgtt ttaaaggaag gcattttttg  75121 tgtcatattt gtatccacac aaacattact tataatttag tactaaatta taactcaaga  75181 tcctctcagt aaggaagttc tacacctttt tcttgaatag ccagcaagat aagtacgatt  75241 aggaattgtt gctttatagc cgttgctatg ctgctgtaaa caacctattg tttcaaaatg  75301 tggctttatt tgaagtccat tctbittggt gagaattgac tattaaatat tcctattaaa  75361 gaatgccagt agattacaac tgggaacctc tcagttggaa acacttgcca tttcctcttg  75421 tttattatag ttttacagaa tatacagtca gatttttttt tcagtttcca accttgctta  75481 aatgcctttt tttatatgtc cttttgatct tctccaaaac caacaactgg tattatatgc  75541 ctaaagtata tgtcaggctt cataatgaat tgtattatta caactttttt tgtgtcctac  75601 attggacaca agttaatatt acttattggt tcagaacaat tcactttatt gtataaaact  75661 gttttagaaa aatcataatt ttcaaaatat caaattataa tagatacatt atcagttaaa  75721 tacatcatca atcagtattt actaaataaa catacttgga gctattagct agtgctgaat  75781 aatacataaa ttttatgtgc tatgaactta aatgtagaac agaaaatact attatataca  75841 caataaagca caaaatagtc tgacaatagt atcatgattc atattttctt aaaataatct  75901 acttactgtt tcaaacattg atatgtttgg atagatctaa actcttttga gaggaaattc  75961 tagttactat gttagttcag atcattatta atggcaagaa caaattgcat aagggaatta  76021 aactccagtg tttacggtaa gctatttggt atttcagaaa ttctaccata gtatctctct  76081 ctgtgtatat gtatgttctc attcaccctc accgtgaggt ctcttttttt ttctttttct  76141 tttttttttt tttttttttt tcggagaggg agtccacctc tgttggccag gctggagtgc  76201 aggtgcagtg gtgcaatctg ggctcactgc aacctctgcc tccojggttc aagaaactct  76261 cctgcctcag cctcccaagt agcbjggatt acaggcatcc gccacgccac ccagctaatt  76321 ttagtatttt tagtagaaac gggatttcac cabittgggc cggcbggtct tgaactcctg  76381 acctcaagtg atcctcccac ctcagcctcc caaagtgctg gggttacagg cgtgagtcac  76441 catgccccgc cctcattgtt aggtttctga tcagcataga ggcaaggtca ttactgatga  76501 ctgttatcct gagattctag caaggtgctt ggtatcatgt aggtactgaa taaatagtta  76561 ctgaaaacta aacaaggaaa gattttaaat aaaaatttta aaatttagaa tttctttaac  76621 aaaaatttaa ctaaatcttg gctgatgtga atgatgataa agaacaagag aaagaagagg  76681 aggaagagaa atccaaacat tacactgaaa tcaccattat tattatccct attttatagg  76741 taatgaaatg gaggcttggg gaagttaggt aatttttcca agtctcagaa gtagtaaatt  76801 gaagatccag gactctaatt actgtctgtt tctcaagact aagtaaactc ttgtttattc  76861 ttacatactt cgtggagtag ggaagttgcc agtgatttga aaatgttatg tatttatttt  76921 gggagggcgc catgcaagtt tataatgcac ttctaattat tattttttca gttcaaaaaa  76981 tgtatatttt ctaagcacat actatctagg aaaaaaagct tacggaaatt cttagtaacg  77041 tagggattaa atatagctat gtaaaaattc acaaagtggt ctgtaaacaa gaaaatagaa  77101 tttactatat ttattgaaaa ggcagtagaa actgtaatca tgtctaactg ataagagtaa  77161 gtcagtcaat atacacacat gagaccagca cagaaagaat tagaaaaatt aaagaggcct  77221 ctttagtatg tgacaagagc tggtataggt acaattatat cttaatacat acccagatgg  77281 catattccca gtagatatta ctaattttcc tgaagttgat agataaataa aactcaatta  77341 tcaagactct ttctactttt aatattatca aaggtatctt tctctggact cttaaaattt  77401 tttcacactg gtatcatcaa gtagcaggtc aaaatttagg gatagaggat gtgtttcaag  77461 agaagaacaa aattttttaa ctttaatttt tcaatctctg ttccttttga caaaattaac  77521 tgaattcagc ctgccaattg ctacttagac acaaaaaaga gaaatgagac attagttatt  77581 aagattttga ttttgattcc tttatgttgt gatttccttt atttccttta agtagttaaa  77641 ctgcaacaaa gatttttttc tctccaactg taaaaaagtc ttccatttta ccacttataa  77701 aagtcttcaa cttagaggaa aagacagttc tctaaacagt gatttggttt tagtgctgtt  77761 ttacctgtct ccttattctt ttagtcagtg tattcaaaaa cacatttctt gcagcctttg  77821 aaagcataga gccacactta gttttccagg aagatgcttt cttaatgtga attagctatt  77881 cttcatctca ccagaacatt cttcaaagct gctgttcctg aattcatgct tgatacccat  77941 gggtggatcc tgatttgtga acattatcta cctaggcatg gatgaggtct ctccatgatc  78001 actgatactg ctcacggcaa tctgtctacc atttggaaaa caggccgggg cagaatctgg  78061 aagggcagcc atcagtggga gcaggaatga tgctgccaag ggttaggggt gggaaaacat  78121 aaactcttct acaatagctg ttagttatct caaatagtgc cttaccttca ctatcaggct  78181 ctgtcctgcc tggtttcact ggagacaatg ccaaatcctg ctgtgcttac ttattacttt  78241 gtttttgcat tgctataaag gaatacctaa gactgggtag tttataaaga aaataggctt  78301 aattggctta tggttctgca ggctgtacag gaagcatgat gctggcattt gctcaccttc  78361 tggtgatgcc tcaggaagct tgcaatcttg gtggaagggg gcgcbggtgt gtcatatggc  78421 cagagtgtga gcaagagagg gaagggagag gtctcagact cctttaaaca accagctcta  78481 gcatgaacta acaggaaaat ctcacttctt accgaaggat ggtgctaagc cattcatgag  78541 ggatctggtc ccatgaccca ttcatctccc gccagctccc acctctaaca ttgggaatca  78601 catttcaaca tgagatttgg aggagacaca gatccaaacc atatcagatt acaaacactg  78661 tgcgtgtaag caaaattgtt tctgcbggtc tgagccactt gagccctttc ccactagtca  78721 catggagcac ctcttcttgt cccccgtctc cactgctgct tccttcctac agcccctgcc  78781 ctgccacagc ccttggaacc acatcgggtg ctggttatct cctgtcaatt cttgttacat  78841 ttgacttccc gaagacatgt ggccctgtga ccacacacac ctgtttgaag ctctcccctc  78901 tttctctggc acccgttggc ttgacagtct cccctcctga tgctccatca ttgttatgct  78961 tcttcccaga catattcact agttcctttg cctcttccca cctcatagat gttcctgtgc  79021 cccaggtttc tattcttaga cattttctct tttcatttag agtgctcatc aagtaatctc  79081 atcaatgtcc aagactccaa ttacagctta aatgttcatg acttttcaat ggctctccta  79141 aactctagac acacatatgt gactgcctac tagacctaaa ttcttaggta caccttccta  79201 ccatctacat tattgcagag cttaaataat caaattataa attatacaaa tataaaaaat  79261 aagtaatttt ataaatttat taaaaattgc tttttaaaac cactttgtat gtcttctgta  79321 gtgctagttc ttaatataga ttccatagat gtcttaaaag atagaaaaat tgtagcttat  79381 gaagacactg cagaattctc tcttaaaata ggtatatata gtgcaaagga ttactgccat  79441 tgcaatattt cacctaatca aagattttat ccaacgtgta taaacgggta tctttttaga  79501 taagaaactg gtcaaaatca taatagtggc atatgttgag gtcacatagt gaagttatct  79561 atgcagatca gacagtattg tggagaatac ctagaatctt gagaatttac acaaatagta  79621 ataacttaga tctgtatagc aaataatata catatcagat tcatttagtt tatgtaatct  79681 ttataatctg agaataatga gtcaagtgtt atccttagtt tactgattat caaagaaaaa  79741 tacagcttgg agaagtcaaa tgaattttcc aaatttatgc tacttataaa tgggagagct  79801 aataaaagcc acctgtctgg gtataaccct gtacctattt cttctaaagc atattgtttt  79861 ctaaagaaag tagttacatt ttaaatgaat atataaggaa tacatcttga atgaagacaa  79921 tatgcatttt ataatttaca tatttctgta tttcattatt cagaattcat ttaaaaagtc  79981 tccttgttgg catggacaaa attggcagct aatcctatcc cataaatatt ttcaatggtc  80041 ttcagctgat ggcgtgaaag ttcagcaaag gccaagtcac aatgctttga agtttgtcat  80101 cttttttatc actgctcaga ttgtcatgaa gacaccaagt aatacatgga tcaattatag  80161 ttaaatgact gcaagttgat cttatcaagc agttagtggg caagatttca cttttaccat  80221 tttttctggt aatgatttag agtgtaagaa cactaggaat ttaaatctac ttagttttac  80281 ttaatcaatg atgtatttgt ttatttaatt taaaacattg tttttggaga aggaagagaa  80341 cacaagaagt tcttgatcca taaataaggc gttcagaagg agaccagtta aactaaattt  80401 tgactgtaat tcagaattgt gtaaaatgcc ctactttatt ttaagctcat tattttcata  80461 attcctttac caagatagca gaaacatggc tttatctatt aaattataaa tgtagttttt  80521 tttgttttaa acataatcaa tttataagag atctaagaca tataaaacta cattgaggta  80581 gaaatttaat aaaaattaac tttacatcta tgtaacttac gtctatgtat tcagtttatt  80641 taaagtaggt cataaccaag tatttctggg ttgtgtggcc aatagctttg ctcctaaatc  80701 acaaagatgt ttctgtgtgt gacacttttt aaatccctgg aatattttaa atgttcattt  80761 caaataatct ataactttga aacagttctt ttttcttgaa cacattgttc tgtcacgtct  80821 aataggataa ccaattagtt ggttatccta attctaatat gcttcataac tagtgacata  80881 agataaacat atggagtatt tattactctg ataaaagata ctggttagga gcaagacagt  80941 ttttactttg taatcataaa aacatagcgt cctgcgtaca ctaggcagct acttatatag  81001 agctaatctc actctttttc ggactccaat atttaccata aaagtgcttt acagcatcta  81061 tataattttt tcttcttttt gtcccttctt tgtagttatt tgaaattaca gtgcctctct  81121 ctcaaggccc caaaccagta acaatcagtt ttgccaatca cacttcctgc cgatgcatgt  81181 ctaaactgga tgtttacaga caagttcatt ccattattag acgttccctg ccagcaacac  81241 taccacagtg agtatgaatt aaatctattt tttctgcatc ctctactaat attaaattat  81301 tttcaagtaa acataagtta aacaaataac ctctgtgaaa tttactgtaa tatactctgc  81361 ttcaaataca aaacaaagac aaaattttgt atagtataca atgaaaataa actgaaaatt  81421 aaaattcagt gggaagcgta ttttagaggc aaagtaattc acaatataaa agaagtatgt  81481 ctgtgaaata aaacacattc caccagtgtt cataaaatat cagtaaggta gcttaattga  81541 tttaacattc ctgaaatcag gtatgctaac tcataaatca tattaaagtt caaaacattt  81601 cagccttgat aagattttag gccaaaacaa aaagtaaata taaataattt tatatctatt  81661 agcattcagt tgctttcttc aatctcaaac ataaaaatat atatgbitgt gtgtgtatat  81721 gtgtatatat gtatctccat gtttcttatt tcagcaatat ttgaatagtg aaatagtgct  81781 taattacttg aaaaaaattt ctgttaatat catttcaaat tgacattcaa accattattt  81841 gttattcagg tttcctttcc atcctatttt tttggagggg caaatggcag catatacctc  81901 atgtgatcat ataggagaac ttatcacgtt ctcctgtatg atcatgttct gaccctgtga  81961 atagctgata atgaattaat atgcattact gcctaagatc tgagagtttt ctgccccaaa  82021 gtagggatgc aaccctttgt tccttaggat atccggtgca tatggatgaa acttacataa  82081 ctctagcatt tgtaacaaat gtataaataa attgatcaaa atacatatat attacaaaaa  82141 agaaaacctt acatttttaa aagactcaac aataaatgta atatgcaaac catggttttc  82201 cccactgaat cacgttgtac tactctgctt agtgtggcag atagggggac cccttgtttg  82261 tccagggaca gtttaggaaa acctggaaga tagcctaatt tgagtgacag agatctgtcc  82321 ccttttatgt gagaaagcaa agatcttaca gacatttgtg aataaatgta tgctaataca  82381 agcaagagac cactaccatc tgaactcaag aggatgccgt atgtgcaatt tcatccccgc  82441 aggctagaga gttctgttca ccttcctcag ccctgagcag aagccctcag tgactcctcc  82501 attctgagag ctttagccat tatctccata ctcatggctt ccaaaatgac atttgaagat  82561 ctaaccatat ttttgactta taatatttta tctaaatcta tcttctattg ctttgcttgt  82621 aattatatta gctgtaagta caaagagaaa gacttgttaa atcctttatt tctacattat  82681 tcatggcagt gttttctcat tttctttgag gccttgaaat cacagagttg tcattacttc  82741 ttcttcttct tctatcccat ctaaacacaa ttgattattt tggaggaggg ggagatatgt  82801 gttccaagct aaacttatat ttcatttcca tcactgccat tatcatccac ttcattatgc  82861 atgtctctga tctaatgcag tgatattaat actagttttc aagcatcaag tctttctcct  82921 gttgtataat gtcactgttt tatgaagtaa gctttaaaag gcatcgtttc attcatctca  82981 ccagaaacag tgactttcag ttgctcaaag aactgagcac aaatttctca ccaccctatt  83041 ctggtgtcag ccttcctttc ttgttttgtc ttccattatt cacccagtct gtgtttcacc  83101 aagtccgatt cccagaacgc caagctcatt tcctgctctg tatcttgttt ctattctggc  83161 cctggcttgt gttctgcctt tccaaagccc tctccatttc tcagagttca ggtaaaggtc  83221 tttctcctgc atttgtcttg tccgaatacc acggccaact ttgcttcttg aatacccata  83281 gcactcactg gattaacttc atcctcacat ggctttatca gggtctgcaa atgttgcatg  83341 tggaactgga ttatgagagt gtttccagta agtttatatt gtctgcaaca ttcagctaac  83401 aacactcaaa aatacttgag ccattcctgt gctctcagcc cctttacctg cattgtctga  83461 tttaaccctt aacaaaatca tctagaaggt cagcagcagc atttgcctta ttttacagat  83521 aaaggtggaa atcacactcc aaagcbgttg gctaaataat gtacataaat gcttgttaaa  83581 taaaatgact catttcctgg atgtatttta tagcatttgc catgttttca tcattactta  83641 ttcatataac tactatccta tacactgttt gaggtcaaga agagacagga agctacagca  83701 aaaagagcct gagtcttaga gtaagccata cctgattctg aattcagatt tgccactaat  83761 tcattctctg tgatcaggta ggtgttttat gtctctgaaa ctcagtttac ttatatataa  83821 actgtaaaga tgtaaagagg attgaatgaa gtactgaatg cttatgcaat gcttagcaga  83881 gtgtctggta tccagaaggt agtcattaaa gggcaaattt attattacca ttaatatcta  83941 agtctgattc atttcctcac ccatgtgttt ttcagtattt ttaaaaccac tatctacagt  84001 aagaaaaaca ttttatattc caaaccagga tgtgtggtat acacacacat agtgtgtctc  84061 tgtgtatata tatatgtcga tattagagaa ttttaaatta gctagataac ttcacatgta  84121 attaattatg tataagcata aaactaaaac aaattaccat ttaaaaatat tgtccttaat  84181 tatggtgctg ctcaagcttt ctcattatca caaccccaag gatcctttta taaacatttt  84241 ttccctaatc actttcccca taaaatttta atgtaacaaa tatactctgt ctttatacta  84301 tatgtatctc tgtgctttat acataaaaag gaagtgtaaa gtttactttt ttgttcaatg  84361 tagtgttaaa taacaaataa aatgtttaag ttaacattta aattaaaaat ttttaatctc  84421 ttaacagcta acataaattt ataattgtat ttgccaggaa acttttaagg taatctgttt  84481 acttatataa attgtaatat atcaaattac atatgcaaag taacaattga tatgaatata  84541 taatacaaat ataataattt ataaaaacat tcaaaatcac tatttttcca gcaaaagtaa  84601 aataattttt aaaataactt ctttaaaaat atttggagag cttaactatt aactttgctc  84661 agtatgagaa aacttttaac ttatatagat gataaatatt aatttagata ttgtcaactt  84721 tttcttttca tcatttgaca tgtaatggta tgactaacat ttgtagaatt aataataaaa  84781 tataaattat tattatttaa ttctcaaagc tcaagtcaca catgaaaaca ccaaggacca  84841 agcataagca atatccacag ggcaaccaat ggcagccaat aggcccacat aggtaccact  84901 cagtatatgt ttgaaatcac tcagtcaatt aagagaaaat cctccagtca tagccatcta  84961 gtcaccataa tttcatagct catatattgc aaacacttgg ggtgtgttcc gttgccaatg  85021 ctgttcatgt aatggccaat aaaaccaaat agaatttaag tattaaggaa tattattttc  85081 ttgggttttg gagagccaaa aatcattgag atattaagat tttagcccca tccaggcctc  85141 atacccaatt tttaccccct tagagatgat tttactccct ttatgaatat ttgccttatt  85201 attacgtgtg atatacccaa ataatttttc tattctgttt ttctttgtga aaatattggt  85261 ctcaaccctt tatgaattat ggcccacaat tcaataaaag ctacactagt gataatatat  85321 atatgatgga catgtgacta tgttataaaa ttctaacatt tgttaagatt taagaggaac  85381 aatcaccacc acggtggcta aaattaaaaa cactgacaaa aacaagtgtt agaatgtggt  85441 gcaaccaaaa ctcctatgtc accaatgggc attaaaattg ttcaatcatt tttcaaaaca  85501 gttgacagtt tcttatgaat ttaacatgta catatttcca cacaataact tgtgtacaaa  85561 tgttctttat tagtcaataa ctggaaacaa ctcaaatgcc catgaaagat gagtggatta  85621 acacatctta gtatatgcat acagtggaac attgctgagc aatgtaaaaa gaatgaacta  85681 ctgatacaca caagaacata aaaggatctc agagacatta agttgagtga aataagcttg  85741 gctaaaaaga gtacattctc tatgatttga tttacatgag gcccttaaaa gacgcaaatg  85801 tactctagag tgagagaacg caattcagtg tttgtttgag gatttggatc aggattgact  85861 gacaatgggc aagagagaca ttgtgaggtg ttagaaacat tctttatttt gattgtgaca  85921 gtagttaatg tggatacata aacttacgaa aagatgataa attcaaaata ggagcatgtt  85981 attgtatgca aattattccc caataaaatt gatttttgaa aagcctagaa aagaattcct  86041 ttattaagta caatttttta agtagcttag gtttcaaata gtagatttct cttttttttt  86101 tttttttttt tttttttttt gagacagatt ctcactctat cacccaggct ggagtacaat  86161 gacgtgatct cagctcactg caacctcctc ctcctgggtt caagcaattc tctgcctcat  86221 cctcccgagt agctgtgatt acagttgccc gccaccatgc ctggttaatt tttgtatttt  86281 tagtagagat ggggtttcac cattctggcc aggctggtct tgaactcctg accttgtgat  86341 ctacccgcct cggcctccca aagtgctggg attgcaggca tgagccacca cgcccagcca  86401 aaatagtaga ttttttaaaa cctttacaat aacattttaa gtcaaatctt tgattaggga  86461 gggagatttc ccacagtcat ccaaaaacta tacgttgagt cactaagata aagaatgctt  86521 ctagatccta ttagagaaaa caaagatgcg cttggctggc tctgaactta gagcacttat  86581 agtcaagtaa gaacaacaca tattatagtt acattattat tgttttattt tactaaatat  86641 tacaaagcac caagcatctg ccacacattg tctcatgttc atacaaatac tgccggtggc  86701 tccattcgta atacacatca catagtacaa ggctgaagag tgtggatgct gtagggagct  86761 tccagttttg agaatttagt ctctgatttc tctttgagtt tgagtaggtt ctgtaaactt  86821 tcttgtgaca catttttttt aatctacaaa agagcacata agtaagaatg ttacatataa  86881 catcatacag aatatttata agctaatctt cactgaaatc aatctgttca atagcattat  86941 accatatttg acataccata gccatgttaa tctgatattg tagaatagca tagtataata  87001 ataataactc ctaactcaag gabittgtga tctttataac cagcaatcca tgttaaatat  87061 tagcacagtg cctaaaacat attaagcatt caataaatga tcgctactat ttttactaac  87121 atcctacaga tttggaaatt gagtcttaga aatgttaatg tgtaaaatgc taaagagcca  87181 aaaaaactgc caggaaaata taaaaattaa aatcatttta tttctgaaac ccatgtgttc  87241 cccccaatat cttctaacat ttctagtatt tacagaaaaa ctttcaagtc tcaatatcag  87301 aaagtttcat aaaagccaga ggaagtagca attctcttta gcagacagag ttagatacca  87361 attttcatat tggtgttctc acagattatt ttttccaatt atttcctctc atattttctt  87421 caaatttaac tccatgtatt tccatgggcc ctttagtaga gactttcttt tcatggaggg  87481 agtcatttgt gattaagtag cgatccccta gattttcctc cttggtagta gtgtttgttt  87541 attcattcat gagacattta tgtcaggtct tctatctcta taatactgta ttaggaaatg  87601 tggggtattt ttaaatgaat aatataattc tttagctaaa ataactcatg tactagagta  87661 caaacaaaca atatttctag tatagtaagt gtctaaaaca ctatgctgta cttcattcac  87721 tcattcaaca aatagcattt gtgtttctgc tagatactaa taaggtggtt agaccacaga  87781 gatagaaaga tacatagaat tgttactcca gaagaaattc cattcttgaa ccagacatgt  87841 aaacatatga ctgaaatcag tgaaatcagt gtggtgagga agcatcttgg agacatggct  87901 acagtagaga ggggatacat gagtctggag aggtcaacag aatcacatat gcccagccaa  87961 ggatgggctg tttcttaaag tctcttgaga actactaaaa gtatatatgc agagatgtgg  88021 tatctgcagt tttgtattat agaaagaaca gcttggtggc aagggagtgt gtggattaga  88081 ggaagcaaaa cgggaggtgg aaaaattcgg gagtaatcat ttgaaataat ctgagtgaaa  88141 aataataaag atggtggcca cagcagtgga tatggggata gaaagaaaag aggtggaaaa  88201 gacgtttgaa atacaagaaa gcatatgact tgggaaccgc atatggggga tggtaaagtg  88261 ggagaagttg aggatgaaac tgtatggatg acattcaaaa gacaaggagc acctgttcat  88321 agtaggaact tacctgaaaa ggagaactga gtttttaaca catgttagct tgagtgcttg  88381 taatatttgt aagacatcag agtggtagag taattggaag agatgacctc aaccaaaaga  88441 aatatagcaa gtaagaagac aagatgagcc acagatgaaa ctgtggggaa atcaatattt  88501 aagaaacagt tatctgtaga gcagacacaa taatctggag aaacagtaat ctgtacggga  88561 gactgagaag aagcaatcag aacaatcgga ataacaacag agagagagac cacaaaagcc  88621 agtggagaca tgagttcaag gaaggaggaa gtggtaagag gtgccaaata ttagaaaggt  88681 tcaagaataa ctgggactta ctctgttagc tgaacagcat gaaatagaga tgtttattta  88741 ctaataactt accatactct gggcacagag agggagaatg tgttttgaga aagggggaga  88801 gaaagcaaga cagtgaaaga aattcacatt tacacatgag aaactgaatc agaaagggta  88861 agtaaatttc cccaatgtca cacaactaga aaagtagcaa agcagagatt caaactaaat  88921 ttgtttggat ataatccatt tcttttgagg tgtggctatg actgcatttt tattgttttt  88981 tagttgatac ataattgtac atatttatgg ggtatatgtg atattttgat acatacatat  89041 aatgcgtaat ggtcagctca ggatattttg gatatccatc acctcaaaca tttatcattt  89101 cttbitgttg taaacatttt aaatcttcta gctattttga aatatataat aaaatattat  89161 taactattgt taccctactg tgcbgtggaa tactagaact tgtttcttct atataactgt  89221 actttggaat gcattaccaa cctctcttca ttccccccac aactgaccca cacttcccag  89281 actctagtaa ccatcattct actctctact tccgtgagat tcactttttg gctctcataa  89341 atgagtgaga acatgagata bitgtctttc tgtgcccagc ttatttcact taacataata  89401 gcctccagtt ccctccatgt tgatgcaaat gacaggattg cattcttttt atggctaaat  89461 agtactccgt tgtgtatata taacagattt tctttatttt taacttctat aaattaaaaa  89521 atatcaaaca tcaaggacaa aacaaaaaca aaacaaaaaa gttcccttct accccaattt  89581 gaaatgtaac aactattttt ttgtatttac taaagataca acccaaatcc ccagtcatca  89641 ttcttcactc ttcattccca gaagtaacca ccactcaaaa attgtattat tctcactctt  89701 ctgtattttt atggcatctg gatttattaa cataccagaa gatattatac agtgcagctt  89761 tgagtgtttt gtattttaag ttaaaatgtt ggcattactt tttttctctt gacattatgt  89821 tttacagata tagtcatatt gctatctgta cacctggtgt attcatttaa taactatata  89881 gcattccatt aaataaacac aagtttttat gtttttttta ttctgtgacg atgtactata  89941 gggaagtcaa tatacactac agattagcaa gagagtacaa tcaaagagga gagagtgatg  90001 tcaaatagac aaggaccttg aagttaatag tgctaaattt attagttatt tggttagcat  90061 ggacaatgtc cctaaagatg taataaaata acacgttctg tgcacagtta ataaaccagg  90121 ttgatttcag tcttaagctg tgaaagcaat tggatattaa atgaaaacac aatactgtga  90181 ttctaaagct ttgagcagca gcctagggaa tttcacctat tctgtagagg tattagggga  90241 gcagaggttg tttctgggta gaggaatgat tgacaagaca abittcagca tagccaagaa  90301 atcttgaatt atttttaatg gataataaat atagaagata ggtattattt caatttggaa  90361 gacagtcgcc tcgtggtgaa aaagagaaaa gggatgaaaa aagatgagga aaaaaaatgg  90421 ataaatctag cctgaaggct aatttgcata tttatttatt tgctgtcttt tatttctttt  90481 attaaaatgt tgacattgtt tactcagtaa aacttatttg cttgcaagaa gttacactta  90541 ctagggttta tttaagaaga ttttattctt atgagaacat gtcttatttc caaggaatag  90601 agtaagtaga tttatagcca aggaaacatt tgatttggaa cttgaggtct ccgtgttttt  90661 ggtotattaa tatttaacag atcctcagtc caaatgccta gatgottaaa tatccataag  90721 ttgtactttt agccataatg cttcactctt tcctttttaa tttgaaggtt atacattatt  90781 gctttaccaa aagacaatga agcaaaatag cctaataaca taaatttaat aaactgtatc  90841 agagcagaaa tggagagata gcttagcttc cagttaattg gaccacagtc tcgtactaga  90901 tcatcagaaa ctactgtttt tcagcatttt aaaacatgca tctttagtct cccctgaaat  90961 tatcctcttt gccagttcaa aatctttatg tccatatacg gttatttttg aaatcgtaag  91021 tcatatgtct gttcatcccc tttcctataa agctcattat ctaaacattg tctcacactt  91081 caaaggatca cctgttgatg tgaatggatt taccagtgga actcaggcaa gagattccag  91141 gctgtgagcg ttactgtttt tgtaaaggga aggtaacttt tatatatagt ttgcctgcct  91201 ttggacagtc ttgtttctac cttctaaaat acgataattg aaagcacagc gttcctatgg  91261 cttgctgata gattgtgaga aataacagca aaatatatac agctgaggag attgcatcaa  91321 tacatctctg caccgaaatt atggcagtga tttgcctaga attgggggct attagatcaa  91381 agattgtcct aaagtttaaa gttacattca accaaacaca tggacaattt ttgttaatat  91441 catattagac cagatttacc agttgttttc taaaatttaa tatacatttt ttaaccattt  91501 taggttacag aaaaagcaga aagtatagag agttttcata taacatcctc tttcacgagt  91561 ttcctctagt tttaacatct tgcattagca tggtacattt gtaacagttg aggagccgat  91621 actgacatgt gatcgttaac taaaatccat agcttacatt agggttccct cttttttggg  91681 tgtaagttct gtggattttg acaaaggtat aaatgatgtg tcaatcatta cagtatcatg  91741 cagaatactt ttactgccct aaaagtctcc gtgttccgcc tgttcatttc tcctcccctg  91801 tattcctggc atcaaccagc cactttgatg tcatatcaac tcttataccc tcataacgtg  91861 ttttttattg tcatcattgt tttgtttttg tttttctgtt aatgacgtat ggctgtgaca  91921 aggtaatgag accagojgct gttgttggag gacctttttt cttaattcct ggttacttat  91981 ccttgaatta tgtgacaagc tgataaatcc aataaccatg gattttccat tgtttcaacc  92041 tgccaatact tctctcaagc ttgtatatcc aagaaaatat aaaaaatagt agagcagaaa  92101 attacaagct tccatactta tcctactctc cctgtgtccc catccccact tctggtggct  92161 ttccaactca gttaagtcct gtacttagcc agttggtgac cacacaatgt gacatgtttt  92221 atatccaagt cagtctcaga ctaggtgagt tttttatgtg gcagattact gcttagttta  92281 tactcagaca aaaaggaaaa aattaaacat ataaacaccc tttttttttt ttcgagagtc  92341 tcatgcbgtt gcccaggcta gagtgcagtg gcgtgatctc agctcactgc atcctctgcc  92401 tccojggttc cagcgattct cctgcctcag cctcctgagt aactgggatt acaagcacgt  92461 gccaccacac ctggctaatt tgtatatttt tagtagagat ggggtttcgc catattggcc  92521 aggcttgtct caaactcctg acctcaggtg atctgcccat ctcgacctcc caaaatgctg  92581 ggattacagg cgtaagccac cgtgcccagc ctaaacccat gttttaaatt aatgcaatga  92641 ttgtattagc ctttcaaaca ttaagactgg caaaattgtt acaactatgg agttttcatt  92701 gattcatcct actcaccatc ttttccttta atatctgaac aaaccccaac tctgttcact  92761 gttctccctg tgagtagact aatggaacaa gagcaaacag taacacaaac agacgctaac  92821 acaagttcat gcagaatcaa taaaaatcag tacaacagaa gataagtcta tgtgtttttg  92881 atacatacga ttaagcatgt gcctttttaa caatttatat aaaacctaaa atatatgtat  92941 ttctgatttt tacctgtagt actgaagaag ttacttaata acgttgaata taaaggccac  93001 ttttacttaa ccaccttcca ttcactatta actgcbgttt ccaaagtgta agcaaatcag  93061 tctctgtgta catagtcaag tgtatacaag cgtcaggcgt aacaaactca agatgaacat  93121 gacagttcaa agatatttgg gacaaaattg ttgaagcatt tttacccagg gctctgtagc  93181 tctgacaatg aaagaatata gttgctcttc cagctgctat tcagacagaa agcttgggca  93241 agaagggtct gtatctatgt tcttcataat acaattacaa gtttgaactt cagataacat  93301 cagcagttgg catgtggaaa accaaaaccc tattttggta tttatcaaga ttgttaatgg  93361 agtcaggttt cccttatttg tttctttaat ggggtacaga acatcctgtt ggataacccg  93421 ctgagtgaca tgacgatgct ctgaaggaat gcatgagagc ttgtggtacc tgccttgaaa  93481 catgggtttc actaatgctg gtggctcaca cttcccattg aacaagacta gagataggaa  93541 ggctatttga gggacacagc tatggaacca taggtgccac atggtaagcc aaatttttat  93601 ttgttgtgtt gttgtgaaaa accttattaa aagagcttcc aatgagagta cttgattaat  93661 aacacagttc gtatctatag aaataatttg cttttcaaga aaatcatcat gtgctacagt  93721 tgaattgaca ttaatgttat cattcatttt gaatgatctg tgaagtattt taagagagat  93781 ctggggaagt aaatcaataa gtagtttaac ataaatcaag gtgcagttaa tttttttcaa  93841 ttagaaatat attacaaaga ttctgtcatt tccaacaacg tgaaataacc tggaggaaat  93901 tgtgctgagt gaaataagcc agacacagaa agatgcatat tactgatctc ccttatatat  93961 ggaatctaga aaagtagaat tcatagatac agaatagaag agtggtcacc acggtcttgg  94021 gggtggggga catggggaaa tgttagagtg tgacaacttg cagttacaag gtgaatatgc  94081 tctggagacc taacgtatag tacagcatag ttactctact caatagtatt ctcactgcac  94141 cccccaactc ccccacacac acagtaactc tttgaggtgt ggatatgtta attagcttga  94201 ttttggtaat catttcacag tgtatacata taccaaaaca tcactttgta taccttatat  94261 atgtacaata tttatcaatc atacttcaat aaagctggaa aaatgcatga atattatata  94321 tatgtatatg tatatacaaa tgtataagag attatagcag attatagctc tttgaaaaag  94381 aataacattt cagcccagtt ctgactaaga ccaaacaaaa ggtgatagca tgttttagtt  94441 ccttaaatgt ggatttgagg agtcaagaaa tctccaagtg taggaaaacc tccgtggcaa  94501 agagtgtaga atatgagaat cacaaaaata gcatgcacaa aatagcctgc tgtgatgttg  94561 aaagtataag agctagtaat tattattatt attattattt ttatttttat tattatactt  94621 taagttttag ggtacatgtg cacattgtgc aggttagtta catatgtata catgtgccat  94681 gcbggtgtgc tgcacccact aacttgtcat ctaccattag gtatatctcc caatgctatc  94741 cctccccctc cctccacccc acaacagtcc ccagagtgtg atgttcccct tcctgtgtcc  94801 atgtgatctc attgttcaat tcccacctat gagtgagaat atgoggtgtt tggttttttg  94861 ttcttgtgat agtttactga gaatgatgac ttccaatttc atccatgtcc ctacaaagga  94921 catgaactca tcatttttta tggctgcata gtattccatg gtgtatatgt gccacatttt  94981 cttaatccag tctatcattg ttggacattt gggttggttc caagtctttg ctatcgtgaa  95041 taatgccgca ataaacatac gtgtgcatgt gtctttatag cagcatgatt tatagttctt  95101 tgggtatata cccagtaatg ggatggctgg gtcaaatggt atttccagtt ctagatccct  95161 gaggaatcgc cacactgact tccacaatgg ttgaactagt ttacagtccc accaacagtg  95221 taaaagtgtt cctatttctc cacatcctct ccagcacctg tbitttcctg acttttgaat  95281 gattgccatt ctacgtggtg tgagatggta tctcattgta gttttgattt gcatttctct  95341 gatgaccagt gatggtgagc attttttcat gtgttttttg gctgcataaa tgtcttcttt  95401 tgagaagtgt ctgttcatgt ccttcgccca ctttttgatg gggttgtttg tttttttctt  95461 gtaaatttgt ttgagttcat tgtagattct ggatattagc cctttgtcag atgagtaggt  95521 tgtgaaaatt ttctcccatt ttgtaggttg cctgttcact ctgatggtag tttcttttgc  95581 tgtgcagaag ctctttagtt taattagatc ccatttatca attttgtctt ttgttgccat  95641 tgcttttggt gttttagacg tgaagtcctt gcccatgcct atgtcctgaa tggtaatgcc  95701 taggttttct tctagggttt ttatggtttt aggtctaacg tttaagtctt taatccatct  95761 tgaactgatt tttgtataag gtgtaaggaa gggatccagt ttcagctttc tacatatggc  95821 tagccagttt tcccagcacc atttattaaa tagggcatcc tttccccatt gcttgttttt  95881 ctcaggtttg tcaaagatca gattgttgta gatatgcggc gttatttctg agggctctgt  95941 tctgttccat tgatctatat ctctgttttg aaccagtacc atgcbgtttt ggttactgta  96001 gccttgtggt atagtttgaa gtcaggtagg gtgatgcctc cagctttgtt cttttggctt  96061 agggttgact tggtgatgca ggctcttttt tggttccata tgaactttaa agtagttttt  96121 tccagttctg tgaagaaagt cattggtagc ttgatgggga tggcattgaa tctgtaaatt  96181 accttgggca gtatggccat tttcacgata ttgattcttc ctacccatga gcatggaatg  96241 ttcttccatt tgtttgtatc ctcttttatt tccttgagca gtggtttgta gttctccttg  96301 aagaggtcct tcacatccct tgtaagttgg attcctaggt attttattct ctttgaagca  96361 attgtgaatg ggagttcact catgatttgg ctctctgttt gtctgttgtt ggtgtataag  96421 agtgcttgtg atttttgtac attgattttg tatctggaga ctttgctgaa gttgcttatc  96481 agcttaagga gatttttggc tgagacaatg gggttttcta gatatacaat catgttgtct  96541 gcaaacaggg acaatttgac ttcctctttt cctaattgaa taccctttat ttccttctcc  96601 tgcctaattg ccctggccag aacttccaac actatgttga atagtagtgg tgagagaggg  96661 catccctgtc ttgtgccagt tttcaaaggg aatgcttcca gtttttgccc attcagtatg  96721 atattggctg tgggtttgtc atagatagct cttattattt tgaaatatgt cccatcaata  96781 cctaatttat tgagagtttt tagcatgaag ggttgttgaa ttttgtcaaa ggctttttct  96841 gcatctattg agataatcat gtggtttttg tctttggctc tgtttatatg ctggattaca  96901 tttatttatt gatttgcata tattgaacca gtcttgcatc ccagggatga agcccgcttg  96961 atcatggtgg ataagctttt tgatgtgctg ctggattcgt tttgccagta ttttattgag  97021 gatttttgca tcaatgttca tcaaggatat tggtctaaaa ttctcttttt ttgttgtgtc  97081 tctgcctggc tttcatatca gaatgatgct ggcctcataa aatgagttag ggaggattcc  97141 ctctttttct attgattgga atagtttcag aaggaatggt accagttcct ccttgtacct  97201 ctggtagaat tgggcbgtga atccgtctgg tcctggactc tttttggttg gtaagctatt  97261 gattattgcc acaatttcag atcctgttat tggtctattc agagattcaa cttcttcctg  97321 gtttagtctt gggagagtgt abitgtcgag gaatttattc atttcttcta gattttctag  97381 tttatttgca tagaggtgtt tgtagtattc tctgatggta gtttgtattt ctgtgggatc  97441 ggtggtgata tcccctttat cattttttat tgcgtctatt tgattcttct ctcttttttt  97501 ctttattagt cttgctagca gtotatcaat tttgttgatc ccttcaaaaa accagctcct  97561 ggattcatta atttttgaag ggttttttgt gtctctattt ccttcagttc tgctctgatt  97621 ttagttattt cttgccttct gctagctttt gaatgtgttt gctcttgctt ttctagttct  97681 tttaattgtg abittagggt gtcaattttg gatctttcct gctttctctt gtgggcattt  97741 agtgctataa atttccctct acacactgct ttgaatgcgt cccagagatt ctggtatgtt  97801 gtgtctttgt tctoittggt ttcaaagaac atctttattt ctgccttcat ttcgttacgt  97861 acccagtagt cattcaggag caggttgttc agtttccatg tagttgagca gttttgagtg  97921 agattcttaa tcctgagttc tagtttgatt gcactgtggt ctgagagata gtttgttata  97981 atttctgttc ttttacattt gctgaggaga gctttacttc caagtatgtg gtcaattttg  98041 gaataggtgt ggtgtggtgc tgaaaaaaat atatattcca ttgatttggg gtggagagtt  98101 ctgtagatgt ctattaggtc cgcttggtgc agaactgagt tcaattcctg cgtatccttg  98161 ttgactttct gtctcgttga tctgtctaat gttgacagtg ggtgttaaag tctcccatta  98221 ttaatgtgtg ggagtctaag tctctttgta ggtcactcag gacttgcttt atgaatcttg  98281 gtgctcctgt attgggtgca tatatattta ggatagttag ctcttcttgt tgaattgatc  98341 cctttacgat tatgtaatgg ccttttttgt ctcttttgat cttbittggt ttaaagtctg  98401 ttttatcaga gactaggatt acaacccctg cctttttttg ttttccattt gcttggtaga  98461 tcttcctcca tccttttatt ttgagcctat gtgtgtctct gcacgtgaga tgggtttcct  98521 gaatacagca cactgatggg tcttgactct ttatccaatt tgccagtctg tgtcttttaa  98581 ttggagcatt tagtccattg acatttaaag ttaatattgt tatgtgtgaa tttgatcctg  98641 tcattatgat gttagctggt tattttgctc attagttgat gcagtttctt cctagtctcg  98701 atggtcttta cattttggca tgattttgca gcggctggta ccagttgttc ctttccatat  98761 ttagcgcttc cttcaggagc tcttttaggg caggcctggt ggtgacaaaa tctctcagca  98821 tttgcttgtc tgtaaagtat tttatttctc cttcacttat atgaagctta ttttggctgg  98881 atatgaaatt ctgggttgaa aattcttttc tttaagaatg ttgaatattg gcccccactc  98941 tcttctggct tgtagggttt ctgccgagag atcctctgtt agtctgatgg gcttcccttt  99001 gagggtaacc agacctttct ctctggctgc ccttaacatt ttttccttca tttcaacttt  99061 ggtgaatctg acagttatgt gtcttggagt tgctcttctc gaggagtatc tttgtggcat  99121 tctctgtatt tcctgaatct gaacgttggc ctgccttgct agattgggga agttctcctg  99181 gataatatcc tgcagagtgt tttccaactt ggttccattc tccccatcac tttcaggtac  99241 accaatcaga catagatttg gtcttttcac atagtcccat atttcttgga ggctttgctc  99301 atttcttttt attctttttt ctctaaactt cccttctcgc ttcatttcat tcatttcatc  99361 ttccattgct gatactcttt cttccagttg attgcatcgg ctcctgaggc ttctgcattc  99421 ttcacgtagt tctcgagcct tggttttcag ctccatcagc tcctttaagc acttctctgt  99481 attggttatt ctagttatac attcttctaa atttttttca aagttttcaa cttctttgcc  99541 tttggtttga atgtcctcct gtagctcaga gtaatttgat cgtctgaagc cttcttctcg  99601 cagctcgtca aagttattct ccatccagct ttgttccatt gctggtaagg aactgtgttt  99661 ctttggagga ggagaggcac tctgcttttt agactttcca gtttttctgt tctgtttttt  99721 ccccatcttt gtggttttat cgacttttgg tctttgatga tggtgatgta cagatgggtt  99781 ttoggtgtgg atgtoctttc bitttgttag ttttccttct aacagacagg accctcagct  99841 gcaggtctgt tggaataccc tgcbgtgtga ggtgtcagtg tgcccctgct ggggggtgcc  99901 tcccagttag gctgctcggg ggtcaggggt cagggaccca cttgaggaag cagtctgccc  99961 gttctcagat ctccagctgc gtgctgggag aaccactgct ctcttcaaag ctgtcagaca 100021 gggacattta agtctgcaga agttacttct gtctttttgt ttgtctgtgc cctgccccca 100081 gaggtggagc ctacagaggc aggcaggcct ccttgagctg tggtgggctc cacccagttc 100141 gagcttcccg gctgctttgt ttacctaatc aagcctgggc aatggcgggc gtccctcccc 100201 cagcctcatt gccgccttgc agtttgatct cagactgctg tgctagcaat cagcgagact 100261 ccgtgggcgt aggaccctcg agccaggtgc gggtataatc tcgtggtgtg ccgttttttg 100321 tttttttttt gtttgtttgt ttgtttgttt ttgagacgga gtctcgctct gtcgcccagg 100381 ctggagtgca gtggcgggat ctojgctcac tgcaagctcc gcctgccggg ttcacgccat 100441 tctcctgcct cagcctccca agtagcbggg actacaggcg cccgccacta cgcccggcta 100501 attttttgta tttttagtag agacggggtt tcaccgtttt agccgggatg gtctcgatct 100561 cctgacctcg tgatccgccc gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc 100621 accgcgccgg gccggtgcgc cgttttttaa gcccttcgga aaagcgcagt attcgggtgg 100681 gagtgacccg attttccagg tgctgcccct cacccctttc tttgactagg aaagggaact 100741 ccctgaccac ttgtgcttcc caagtgaggc aatgcctcgc cctgcttcgg ctcgcgcacg 100801 gtgcgtgcac ccactgacct gcgcccactg tctggcactc cctagtgaga tgaacccggt 100861 acctcagatg gaaatgcaga aatcacccgt cttctgcgtt gctcaggctg ggagctgtag 100921 accggagctg ttcctatttg gccatcttgg ctcctcccca agagctggta attattaccc 100981 aacgtttaga atataatgta acagaacgta tttggaatac atttatcttt taatatttca 101041 aaggagagat aaatgcaaac taagatttta tttatcatta aattcattgt tctttagttt 101101 gaaaaacaca tatactcata tttttgtcac gtgattttaa ccagcataaa gcaatagctg 101161 ccacaccaaa gtcaagtgaa gctgtgaaaa taattaatga aacaattctg ataaaagcat 101221 ctttatcctt catacaggtt ataggcagga ttgtggttgt gcctgtgtgt gtgtgtggtg 101281 gggtoggtgg ggggatagga aagttagttt attcacatga ttctcaacat agacatacct 101341 tgcaaataat tgtgcaattc cctgctttgc tttgcagaca gaatgtcttt gaatcaatgt 101401 cttttataaa tacactatac aaaaaacata attataaacc tttaaagtat ttatgcatac 101461 tttaatattc agaactagaa gagaaatttc tgtaaggaga aatgctttgg agattaaaac 101521 gtaaaggaga taaccaaatt ttactaaacc tctatccatc atgaccacat ttcctttcat 101581 tctaaaataa aaatattttg gaaatgttga ccccctgccc accatttttg cctgagaagt 101641 tttaaatgcg aagaacttgc tcctcacttt tgaagcacgg tgctttcttt aggaaccaat 101701 ctgtatcaca tgcattctat tggtttgtat tttattacat atcattctat tacattttaa 101761 aatgcatttc tgagcccatg tcattgattt catgattcat taatgggttg caagcagcag 101821 ctggaataac actggcttag gtaatggcag tataaatcac abittggtaa aatgaaagat 101881 gcctttctac caacacgtta taatggccac tcgatgccaa catggcagtg tgttacttaa 101941 accatatatc aatcaacaca gaagcgacat aaccaaaatg tttttaccat catttataga 102001 agattatgag tttcatgcag ccaggattaa ttgcattgct attatagaac ttaatataag 102061 ttgtatcata tttgatggaa ggatgctaac tatcaagagg atataaattt taaaaacaat 102121 gatactgttt tggataagtc ctgactgtct gcattttatc tagaacaata tatgttcatg 102181 attaacctag aaaataatga caaaaatgcg caatgagtag agacttgccc ttggaattcc 102241 taaaattatt aggaaggtac aatgttctcc aagaaatatt ggtaagtgaa aaaaacaagg 102301 tttacaataa tgtgtaacgg atgctatctg tgtaacaaaa tgtgaaaaaa catatatgca 102361 attttttggc aagaagatac cctgaaaaca taaaccaaaa agccaaaaaa aaaaaaagaa 102421 acttgctgat gatacagaac ttctctgact gtacattttt ctcatagtct taactctgat 102481 aattacatac atgtttgaca ttctcaaaag taagaacata gaagtacata atatatgcag 102541 gataaagcaa ataacagttt atgtgaagat tgttagaagc caaggttttc atggaagtta 102601 ttagtatgaa gtcaaagtag tacattaaaa tccagtaatg ttaattggat ttggaagtaa 102661 cagtatgaaa ttttttctct aaaaatgtgt gcaggaatct cttgcttaag atcagtaatc 102721 tattcccaaa aatagatttt gagagcacat ttctgttcta aatgggaaca attatagtga 102781 atggaaggta aaccaaaaca tagctatttc ctacaaaata attgatacct aataatgcct 102841 gtagaaaagc atagaaaagt gacaaactct cttgataaaa tctaaaatgt atattgtttc 102901 ctaatcagca attattgatg ttgctaacat acagttgctt tgtatctagt tacatggacc 102961 gtgtatatgc tgtatgagaa attgtcactt tgtggtatag catagcaaat aacacagcaa 103021 tcaaaaagtt aaaagtcaaa attaaaataa ataaaagacc cataatagac tgtttttcac 103081 cttgctaaag gagaaatgac tcttgaagaa actcaagaag ggacaaagaa aggtcaaatc 103141 agtcattgct atttgcagaa ggtgatgggt ggatggagga caagggggca atcttcgaca 103201 aactgtcata tgaagaggaa tgaagagacc ttccccatgt ctgtgtctag tagatgctgt 103261 agagacttgc tggacaggaa agctttggta aatcttcaga aatgatgttc aagctgaagg 103321 aagatgttca agctgcattt tggttgcaaa atgcagattt gcttgttttt ctgttgaaaa 103381 attcctctat gtgatgctgt aagagttacc aggctattat taaaagaaag atgtattgtc 103441 acactgagta tgtctgcaaa actttcttag taactggcct gtttgtttat actcaatgca 103501 catgttaaga tggctacata ggattcttac tatgttctat caatttggaa tgtaactcaa 103561 cattcttcca gcacataaag ttgtttacaa tatataatga gtgtgaaaga tataaataaa 103621 tacttctatt tgatgtctac accaacatta gatgaaaaaa tgaggtagtg agaagttgat 103681 atatatcctg taaattagca tatttaaaac caaaaatcct tctactgggt aaatattaac 103741 taggaaaaca ttctacagga tataatgcat ttttctagct ctgccccctg aaaaggtcta 103801 gtagtaatgt gatctgatgg cactaaacac ttctgatctc aaatgatagc ctctaaaatg 103861 ctgttttcca acaaagagaa ttagggctcc tgaagaaatg gctgatgcca ggtgtggagg 103921 agaaaatgag caagctgagc ttgtgatata tgttcacccc agagagggct catgtcacgt 103981 gggcaccaac agagaggggt ctcaggtagc aacagtgggg ccattggacc atcaaaggag 104041 caattagggt acttgactga agcctgtagg ttcataattt ttactctaaa acaaggaagg 104101 aaggtgggaa gaaaggggaa aggaggggaa gggaaggaag aaaggaggga gggagggaag 104161 gaaggaagta aagagctaga acaacaatga aacaaaatat ctttgataac tttttggggg 104221 agtacagagt ggaaattttg catttctgga ggctttacaa gatggggatc tgtgcttcag 104281 aaataagtca gtaaagatac atttacatag atgtttcctc cagtattgct tggaaaagcc 104341 aaaatcaaag tgatgtagat agttacctaa gagatgaata aaataaataa tggtacatct 104401 tttgtatgga atattacata gccactaaaa ataatggagc agaactctac tcaatgacat 104461 ataaaaatgt ccatgatata ttgtataatg gaaaaaaatt ttaaagcaaa aggttttacc 104521 ttatttattt cacaagctaa aaccctatat gattatacaa accaatgtgt ttgccttaaa 104581 aagataaaag tctggtgtcc tctaagacca taccacaaac agtgatcacc tctgggattg 104641 gaattttata gcagttgtgg gtagagagag tttgggagaa aacattcaca ttttatctca 104701 taattcttat atttttaaag cttttctatg agcattattt tgatacatat gtgagcagag 104761 atggtccctt ctaggtacca gttacaccat tgctaaacct cgtctgtttc ttccaaaggt 104821 gtcaggcagc gaacaagacc tgccccacca attacatgtg gaataatcac atctgcagat 104881 gcctggctca ggaagatttt atgttttcct cggatgctgg agatggtaag cagaatgatg 104941 ctttaaagac taaacgccag gggtctatat tgtgattaac atactctaat attaaaacca 105001 cacatataat attcatcatt cttctaaata agtgactaaa aaatagtaca ttttctactt 105061 cacgttggta ttattttgaa ctcctttata aaggaacata ctcatgtttg tacccaatcc 105121 tttgatggaa aacatacaaa aggaagatgc ttttaaaagc ttttgtttca tgccacaccc 105181 agaaccaagt aaggtatagt aaagattctc tgactatttg tctagactca acagatggat 105241 tccatgacat ctgtggacca aacaaggagc tggatgaaga gacctgtcag tgtgtctgca 105301 gagojgggct tojgcctgcc agctgtggac cccacaaaga actagacaga aactcatgcc 105361 agtgtgtctg taaaaacaaa ctcttcccca gccaatgtgg ggccaaccga gaatttgatg 105421 aaaacacatg ccagtgtgta tgtaaaagaa cctgccccag aaatcaaccc ctaaatcctg 105481 gaaaatgtgc ctgtgaatgt acagaaagtc cacagaaatg cttgttaaaa ggaaagaagt 105541 tccaccacca aacatgcagg taagagatcc tcatgaagaa tattaattta tcttactaga 105601 aatatgctct aaaccaaaag cagttttctt aaccaaagta acaattgctt gttagaatga 105661 ggccaataca ttctgaaaga caaaaatctt atattttttt aaccaatgct aaacttgcat 105721 gagactggat ttgcttccaa aaaagcaaga caggagcctt gaggatcaaa attagatcca 105781 agctcagaat atactctaaa ttagtggttc ctgtgggatg ttttcaaaat acctaaaggc 105841 aatccacttc acccccacca aaaagtagga tgccttcaga cataatttag gacaactgtt 105901 ctaaatgcag acaattttta tgcaaaactt acaaacaaag gacaggagag taccactggt 105961 atagaattat atctggaaat gaaaatacat agctaagtat ttgatagaat tagagaaata 106021 aatgaatatg ttgttaaagg tacccaagac tcatgtctta aacttggttt tgactcttct 106081 gcatcaagaa aaaaaaaatg aagttattcg actcaagcac attcagtgtt aatcccgaaa 106141 cctcttcctc tttaatctca gagaataaat tgatcctact atttaagcca gacctgtccg 106201 tttgacattt tctccacatt ccttcaacat tgcttcatgc cattccttct ttcttctgta 106261 acttgaacat cttcaactct actttttttc cccttagttt ataaaagttc ccaaatttct 106321 tctattttat tagcctctta ctgtgaagtt gagcaaactt tagcaaccca ggtctgttct 106381 cttcaaagct gctcaaaaac gaggcatttg ttttcacctc tttcacctac catgtattca 106441 accaactaaa acctggttta tggcctacag tgctatgtta aacctctgtt taacgtttca 106501 ttggcctcat agttgccaaa tccaacagag aattttgtcc ttaggtaacc tgtcctttcc 106561 atggcctttt tctttaagct cacctcttct atgacatgac attgtacttt cctagttgtc 106621 tacttaattt tcagaccatt tgtttttaat cactttcact ggattctctt tttacatcca 106681 ttctttacat atgggtagat aatgttcttt ttaacagaaa aaagcttgta tttcatttat 106741 ttactatctt cactaatgtt cattattatt tttccacagt atataacgag ttcatctttt 106801 tattctcaag agttttgtgt ccttatttta atgtatattt ttggtggttt tcctaaacta 106861 atattttagc tactggataa aaaggcttta gtggatctgg ctatctcatt gattatattt 106921 ttcttccctt atactgcaaa gtacatcata ggtataattt tattttgaga aagaactata 106981 ttccaatttt acctatatat tcctactgta ataaccaaga ggacatttca aaaatgtata 107041 tgctactatt ttcagaagga tatagatact aaatcttttt aagccttatt aaactatgtt 107101 ttatattgaa ttcttattga gtgaatttag tatacattga aaaatctgaa attcttatgt 107161 ctgcatacct acttttctac agaattatat gaacacagac aatatttcta tcattgcatt 107221 tctcctaata ctatacattc tttcaaaaag actctgttta ctgcaactca tcctagattc 107281 atttttctaa gtgtataatt ccaagctttg tgatataaat tggagcaaaa gagaaaatat 107341 catattttga aaatatatat tctcctcatt ctctcttaat atctattaca aagtgcagta 107401 ggcagagtat atattctttg gttcattgcc ttaattaaca gcttttatgg atcattaagt 107461 atcatatccc tttttagtag aggaatacca gtagtcataa ctatgaattt gcatttgcaa 107521 agtttaagaa aaattaacta gacatgcttt cttttctaga gccaaataaa tgaaatgtca 107581 aaaccaaatt gtgtagggtt ttttatagca cacttttgat ttccacctca ggtcatcttg 107641 cacttttccc tttacaccta ttcccacaca ttaggcatgc tcatactcca aaatgttttt 107701 aaaagatagc tccaattctc accaggcgtg gtggctcaca cctgtaatcc tagcactttg 107761 gaaggccaag gcgggcagat cacttgaggc caggagttca agaccagccc agccaacatg 107821 gcaaaaccct ggctctatga aaaatacaga aacttagcca ggcgtggcca cacatacctg 107881 taatcccagc tactojggag gctgagacac aagaatggct tgagcccagg aggcggaggt 107941 tgcagtaagc tgagattgcc ccactgcgct ccagcctggg cgacagaaca agactctgtc 108001 tcaaaaaatg aagcctcaat tcactggagc aacagggcag gagacacact gaccaattga 108061 taatttgtcc tctcaccgct actggaaact ggaagtctag gatgggagga aggggaccct 108121 cgctgctgag tattgtcctt ctcacctccc tgccccagaa tgcctctgtt tcacctggag 108181 ccaaggtgga aaggaagagt tagtcaccgt catgcagcca gctgccaagt agagacacaa 108241 gagtgagggt ggggctgctc actgaggacc acagttctgc caacatggct gggtttaatt 108301 gcctggaagt ctgggtccca tacaagtccc agactcatgt gaattctgcc atgcttatgt 108361 gatcacagta agtcagcaga ccttcagtgt tcactttcag aatttctgtt ttatgtttct 108421 ttcacccatg aagcaaagag cacttcaaag gaactaatgc ttacaatacc tcatccttcc 108481 atttgttata tcagcaagca agacttttat tttaaggctt ttccattcct cttaaatgtt 108541 gtaattctaa gcagaaacaa acttttttaa acctatgaac aatttcgtca taaaattagt 108601 aattttattc cagtctgaaa tttaaaaaca cagaaatacc ttggtagcat gatgaatcca 108661 ttgccttgat ctttaacgta agtgtgttct tgtttgttct cctagctgtt acagacggcc 108721 atgtacgaac cgccagaagg cttgtgagcc aggattttca tatagtgaag aagtgtgtcg 108781 ttgtgtccct tcatattgga aaagaccaca aatgagctaa gattgtactg ttttccagtt 108841 catcgatttt ctattatgga aaactgtgtt gccacagtag aactgtctgt gaacagagag 108901 acccttgtgg gtccatgcta acaaagacaa aagtotgtot ttcctgaacc atgtggataa 108961 ctttacagaa atggactgga gctcatctgc aaaaggcctc ttgtaaagac tggttttctg 109021 ccaatgacca aacagccaag attttcctct tgtgatttct ttaaaagaat gactatataa 109081 tttatttcca ctaaaaatat tgtttctgca ttcattttta tagcaacaac aattggtaaa 109141 actcactgtg atcaatattt ttatatcatg caaaatatgt ttaaaataaa atgaaaattg 109201 tattataagc tg Human VEGF-D Gene (NCBI Accession No. NG_012509.1) (SEQ ID NO: 83)      1 aagacacatg cttctgcaag cttccatgaa ggttgtgcaa aaaagtttca atccagagtt     61 gggttccagc tttctgtagc tgtaagcatt ggtggccaca ccacctcctt acaaagcaac    121 tagaacctgc ggcatacatt ggagagattt ttttaatttt ctggacatga agtaaattta    181 gagtgctttc taatttcagg tagaagacat gtccaccttc tgattatttt tggagaacat    241 tttgattttt ttcatctctc tctccccacc cctaagattg tgcaaaaaaa gcgtaccttg    301 cctaattgaa ataatttcat tggattttga tcagaactga ttatttggtt ttctgtgtga    361 agttttgagg tttcaaactt tccttctgga gaatgccttt tgaaacaatt ttctctagct    421 gcctgatgtc aactgcttag taatcagtgg atattgaaat attcaaaatg tacagagagt    481 gggtagtggt gaatgttttc atgatgttgt acgtccagct ggtgcagggc tccagtaatg    541 aacatggacc agtgaaggta ggtgagctca atttttaatg tgatgaagtt ctttttattg    601 gctcatacag aggactttct ttgccctcac tatttttgaa acaatataaa aatgcagaac    661 catcctagta gtggactgga caggatatat cctgcatttc ttggtgactg ttctgtttct    721 tagtcttatt aaacttctgg ccatgagtat ttgaaaatgc tggggtgggg gttggttgtt    781 ttttgaagtt atggtagaac atgagcagtc tggaatcttt ttggatggag aagtttctcc    841 toggttgcat atgcagatgg cacagtggtt ttttaatgaa acattgattt gtttttatga    901 ctgataactt tgtgggccat ttattttcag gtctttgtga gcagcagagg ttagtttatt    961 cgtttggtaa attgaaaatt gcagtgcttt ctatgaacat tttctatctg cttttgcaaa   1021 ttaccaattg ctgccatcca gaaaaatgtt ttctcagaga gtgtttggtt ttttcgcttc   1081 ttgaaaggtg taaaattcaa cactaatcaa atctttggtt ctgtgagcaa gcatcaaata   1141 gagcttaacg aacagagagt aatgcaaaaa attaaccaga atgttgctga ctgctggaac   1201 aatacttagc ccaattttat gcatttcatg gattatatat attttaagct tctattttga   1261 aaatgattcg gatgtaattg ttttgactga agtggtgcta aatcattatt gatttaggaa   1321 cttctggcct tgaaaagaca attaaatgtg agtttgagtt tttgtagctg ttgtttagga   1381 cgtgcatttt caacaggggt gatatcgccc ccagcagggg aaaattggtt cgtggaggga   1441 tgaaaaagtt ttaccctttt gatacatcac gcacagacgt acatacagta catatggtat   1501 gtagtttaaa atacgttata cattcaaatt gcataggggg aaagtgtctt caaaggctcc   1561 tggcbggtgt tggtggcctg gcgagggtgg gggctgatat ttaaaaatgt tgaacactga   1621 gctggaggtg agtgggaagt caccttgtct ggcagccagc acttttctaa cttctcaaat   1681 tccaaattta catgggagaa atcacagtgt ttggctccat tttactgcca ccagccttga   1741 tattggatct caaggccaga ttgtaggtaa atgggaatct gactgtaagc ataggtaaca   1801 ggagaaaacg gtctgacttg tttgaagcaa gtaagacttt tccgactgtc cagctttttc   1861 gtaagttcat gaaacagaaa tcctttagat gtgctgggct cctcgagttt taaaatattt   1921 ccattttcct tgtaaaacat cactttatct gatggtataa taaaggagac tgaattgttg   1981 gacataagtc atattcttta ggttgctcag ctctttcaaa gagcacaagc accaagaatg   2041 tctcaggtgt cctgggcact gtgaagtttt atttatttat ttatttattt atttgagacg   2101 gagtctcact ctgtcaccca ggctggagtg tagtgatgca atctcagctc gctgcaacct   2161 ctgcctccog ggttcaagtg attcccctgc ctcagcctct cgagtagctg gaattatagg   2221 cacgtgccac catgccgggc taattttttg tatttttagt agagacaggg tttcactgtg   2281 ttagccagga tggtctcgat ctcctgacct gatgatctgc ccgccttggc ctcccatagt   2341 gcbjggatta caggcgtgag ccaccgcgcc cggctggcac tgtgaagttt taaatgcttt   2401 gaatgtactg ttaatatata aatttgttga atggagtaac gaaggaaagc agctgaattt   2461 gcatgtgaca gaaaacaagt tgttacacgt ggaggatgca gcattatata cttactaata   2521 cgattagcaa ttttttttca gaatatatca gaatttcctt taaaaagtga agctacatat   2581 actgaactta tatccaccct acccctcgct caattaaatt atttctgata tgaaggaaag   2641 gattgcctat agctaaacag aagttttggc atagatatga ctgagtggta agggataatg   2701 agatatataa tattggttat agttttcttt tttccccaac ttttaagaaa agaaaatcta   2761 agaggaaata atgtttctaa atgttaaagt tcttcttgtt aaaattaaaa tgtagtgtga   2821 aaacatattc atggtggtaa tggtttaggg tggtggtatt tgaatttttt gttttttttt   2881 ttttactttt tgaaataaaa tgttttattt attataagaa attcatggtc ttcctcggta   2941 cttggtccat atgtatttct ttctcctcac cctcccctct tctaaccacc tcttttccag   3001 aatggatggt gatgccaatt ttgctcctag gttgtcctcc agccaccccc agcccagttt   3061 tcactttcta gctttgaaga ttgtccagtt ttccagctta gactagcatt gcctctacga   3121 tagttctagg tatctgtgaa gatttttttt tttcctgtag caatcatgaa atagctacta   3181 gtgctctgga cgattgtgct taatgccatt tgggtgtaag gcctcctaat ttcattagtc   3241 ttaccacttg bitttgcaag gatagctgtt tggagtcagc agtgcatgga acatgtgaac   3301 tgagacaaat ctgtttgaaa atctcaactt aagatttcaa atccactgtg tatactattt   3361 agcbgttaag tttctcagtc taagaagaac acgttttcct ctagaaataa gcttaaccca   3421 gtacctatgc atcgttcatt aatataatca gattacggcc tagatgtgga atttatttct   3481 gtttctattt tctccagctt tttaatacag ctcagacagt catatacagt tgtacacgat   3541 gtgcactgca caactctagg gtgctccatg catatagaca tatctgtatg tgacagccct   3601 aagtacaatg tggtagacac tctggacatt tggtaaataa gtatctacat cctcactctt   3661 ctctcattca cattggcctt ctggccagca ctatttctgg tttatttaat aaacaattct   3721 tgtcccccag aaattctgtg agtcttctga agatgccggg gaaagccagc cttcataaat   3781 cttttcaatg tcactaatga agacatgtca ctattgcaac aaaggaatac caggccatag   3841 taggctttca caactttttt ctgacagaat ttgtttcttt ctgctttatc ttccctgtgt   3901 actgtctttt tttatccacc ctctttctta attacactgg tagaagaata ttggtgggtg   3961 atggagtcat tcacattctg tgtaagacta gaatcagtcc aagatccaca ggaatgtggg   4021 atacttcttt catgagaagc cacatggctc acaagacttc tttacatttg tgttacttgc   4081 cttctcctga aattgtotct acagtgaatc aaataacaag gactgaggtg tattttccat   4141 atttaattcc aggaagcagt cccactcctt ctccctgccc gatttccagt tccaaagtca   4201 tgtacaggga agtccattga ctttgatgtt ggtcaaatgg cccagcaagc ttttgtccac   4261 ttttctgtca gacacagtcc ttggcacaaa agacatctga aatacttccc attaatttct   4321 tctttattta tgaccttgta gttaagtgtg ttgaattata tgcttctata cacatctgtt   4381 ttaatccagt tactcactta taactggtga ctgaaacttt tatatcacta tagcgtatta   4441 ttggtaccca ggatacaata gaatcctcaa tatcttacat cttcaatata gtacttcctt   4501 gtatgactta tttcttaaca taaaaatcct gttttagacc tgtggataaa cctttactat   4561 aaatcccaga gacaatttct ggaatgagaa tatagtattt gtccacacac atgattccat   4621 gtagaacttg aggtaataag atctgggact cccagataca tttattatta ccacaattgg   4681 atagaggtgc tacagaaata ggcacacaaa tgacagtaaa attgtttctg agaacatttc   4741 taggctcaac ttttttctac aacttaggat gaacagagag agtggaaact gtatataatt   4801 gggaatgtga ctgagatgag acaaagatga catggaagca tttcttcttc ccttgctttt   4861 ctggtggtaa gttcactctt ctgtcttcct tgccactagt tcttgcagtc cctaccaaga   4921 cactagggca ttatacagca aacacaccct gaggccccct gctactgcat catgaaagcc   4981 ttagctggtt gtgatgtcct agttcataaa gaatctgcct agtctctcat tagagctttc   5041 caatatttga caattcattc atttattttt ttcaacaggt atttattggg caccaatata   5101 tctaggcatt gatctagggg ctgggaatga agcaggaaat aagtctaggg gctgggaatg   5161 cagcaggaaa taagacaatg tttcaattct cttggaattt gcattccaag tgtgatgggt   5221 agaggcagac aatatgcaaa tgtgtaacat gtcaggtgtg ataaatgcta tgaagaaaat   5281 caagtagggg gagcggatac agtactgaat aaatcagagg agacctttct gattcagtta   5341 tgtctctaca gagtcctgaa ggtaataaga gagacagagg caaccatcag tgcagtggcc   5401 atggtgggcg cagcaagttg gcttcgatgt ctgggtatta gccagggagc cggtgcagct   5461 ggaggtgggg tgagtggagg ccagaagtgc agttgttgag gttggagaag tagccagaga   5521 agatcatgta aggtgtgact gtgctcccat aaaactttat ggacactaaa aattgaattt   5581 tatgtaattt tcctgcatca tgaaattaaa aaaaaaattg tttcaaccat tggaaaatgt   5641 aaaaaattgt tcttagctaa caggccatac aaaaacaggc tgcaggttag atttggccca   5701 tgggtcatag tttggcaatt gtgttatata taaattatta cactgtttta tcttcatcat   5761 ggtacacatc catacctgac atgttttatt tgcctgtgta tacatttatt gctttgtcac   5821 cgtctactag aatacaagtt ttttgagaaa aggagctctt aattgtcttg tttactgcag   5881 catcccaatc accagtgaaa agcctgtatg taatagagta gatactaaaa acagtatttg   5941 ttgactgatt gatggactag acctcaggat ttttagatac ccaggatcag gatatgaact   6001 actgcattaa atcatctcca acatctactc tcatgatggc ttgtctgact tcatgattta   6061 aaaaaaattc taaagcattt ttaaggcagt atattcaccc tgtgctattt tcctgtgggc   6121 ataggatagg gtttgtgtgg atgtatcaaa gacttctcca ctgtccttcc aggcacaagc   6181 catcctataa ggcgttccct tttaggagcc agaggtatag aaggaagtca tctgagccca   6241 ttattccagc ctgttggtaa cagaaagaga gatgagcaaa gtagcatttg gctgcacagg   6301 ggtctggaca aaacttcaac atcttgatgt tttccttcat ccctgagagc cttagaaatg   6361 ctacctatgc tttcatttta bittaggttg tttgtaaaat catggtaaat tatggcaaaa   6421 tactctggtc agatacttta tcaggttagg ccaggatatg ctgtgaaaac aaacaccccc   6481 gaaatcttgg tggttcataa acaacagaga cttatttatt gcttatacca catgaccagc   6541 ctggttcatc tggggtcaaa tccacatggg gatgaagctg gctgagtatc cgatcttgaa   6601 tgttaggaat cactatgaca gagggaggga gagcctgaga gcgcctcacc ctggcactta   6661 aattctctgg cccagaagtg acacatatta cttctagttg cagccccttg acccactgcc   6721 ccatctagcc acaaagggcc aggaagtgca atcccaccat gcgctcagaa ggcagagaga   6781 tggaaatatt tgacaaaccg tattaatgac tgtgacacat ggtgagttct tcacattggt   6841 gacttctaag tgcttctgaa cacacctttg actgtagaat gtcaaaaaca ttctcaattt   6901 tacagcagtg ctggaaaatg aattgtattg agacaacttg ggaggagtag aaggagatgg   6961 aataaaaaaa attcactgat ttctgtcatg tgtcatgcct cctttaatgc acggaagaac   7021 gtatactttg cttaggaaat cacattacca cattcagaac aactttagtg aagatgggaa   7081 acaaccatgg ctggtcaatg gggtaacgtg tgctgaagga agacaggttt atttctcagg   7141 aggcatcttc tccctgggaa aaggaaagac acatattcat ctcagtaaat atttgtggaa   7201 tgtctaccat gtgccaggca tatgagtgga aatgatgttt ttataaaata aagatgtctt   7261 aagtatttgc atgtcttact aacagtcagg gagttcaact tggccagtgg gaaggataat   7321 tttatgcctg aaactttagt aatgtaaatt tttatgctga ttctcttttt gtcattcact   7381 gagtattcct aagtaactat aacactcaca tattggagat aagtattggt ttcctgaaat   7441 ctaggtttgg ctaacattgc ttctggaaag agaaaataac abitgttgaa tgtccctatg   7501 gcaaattctt gctgttactt actgttccat tatggagagt gttagaaaga gtgtaatttt   7561 gattgaatga atatgctaaa aaaaacaccc taaataagaa actcacaaaa agaacagagt   7621 ggaatgaaaa agtgaaaaca actttgcaat ggtgtgcttc gtttataagt acattgtcac   7681 agcaagacta gggatgattg ggcatcttag agagtgcaga ggatgttgat aaggaagagg   7741 aagaggagat aagtggattt tgatatggga cactagatcc ttagggaaga aatgtgaaag   7801 agggtattct gggctgactg ccgctggcat agcaaggctg ctttgtagaa gggacaataa   7861 agttttgcat aaggatcctt tttcccatcc aatggattat gctatacttt agctggaata   7921 gggctgtagc agttagctat tgccacaata atgctgtgta acaaagcagt ccaaatttca   7981 gtggcttaaa acatcactac cttattctca cttatgtctc caagtcagct gggagtcaga   8041 ggattaaggc tcaaggctta ggtttggtgc aggtcagccc caggtgtctc tcatcctcct   8101 ttgatcagtg ggctagcagg agcatgtgct tgcaatgatg gtggaaatag aaaaacgtgc   8161 aatcatatgt gagtttcaag cctctccttg catcatgtct tgtaatgtcc tattggtcag   8221 tagggcbjgg aaatatatcc ctccctcaga gagtcaggag tggaaatgaa aatgttttta   8281 acaatagcct aatcaccata aaggctttgg gtggcacact gggcccttga tcttggagat   8341 cagtgataga ctgtaacaga cctcagaaac cccttggggt tattcagagc atacttctag   8401 agggtctggg gttgtcttgc cattcaagcc catcccacac ccatctgccc ccacatatcc   8461 taagcacagt tatgtcaagt gagaacagag gcatttgagt ggagcacaga tttcaaacac   8521 ataaaggcag ggcatggcca tctcccgcag tgctagatga tctggcbggg agaaaaccac   8581 aagcagtctt catcaaattg gaggatgtgg aggtcccagg catttagtcc cctagtatgt   8641 ccttaaaaaa cccagacagc catgcacaca cactcacaca aatgcacacg cacacacaca   8701 tacattcaca cacacactct tttcctgcat ttgtagttcc tttcctcagt ctaagtttaa   8761 ttaaacaact tggatttcat atatattcat ttaaatatag aattgcataa agaaaagagc   8821 caccagaacc accaatggta gcatgaggcc tctgaaatga aagatgagcc caccccaacc   8881 ttaaatggcc aggtttctgg atttcagaga agcaagatca gacccttggc aggttccatc   8941 tgagcagcca cagcagccat agctacagca ataattatta gcaagtgtgc gttctccctg   9001 ccctagttag tacaccctat accatcaggt gtcatctgtt ctagttaaag tcagaccgta   9061 ataacaaaac atcaaaatgt aaaatgtggg ttgttttttt ctttacacac ttctaaagac   9121 atttaaagcc tgagcagata ccttaaaatt catcttctat ctgaaaatac ctcctagaac   9181 cattttaaaa aggagatgga ggcaaggtgg agagaaaaag tttgtctttg gttgacactg   9241 ggaaagttgt cttttaaaaa attttttaat gtttatttac tatggagttg ccgtgtcttg   9301 ctcttttcaa gctcacctgt cojgcttcta aggaatatca ggggccctaa aacacagact   9361 tctaaacccc aacacatagg acacacctaa gtgtggaaag aaaggaaaga ggcaggaaag   9421 aaaggaaaga ggaaggaaag aaaggaatgc aacatttatt gtgtgcctac catatacctg   9481 accctttcct acatatgacc acatatgatc tcttcatgag ctttatgagg tgacctatta   9541 ttaacaatgc tgctttataa atgaggaaac caagccttaa ggaagtcaaa taccatatcc   9601 tcagtcaaat agctaaaaaa aaaaaaagaa aagaaaaaga aaaggtagtg cctggattca   9661 aagacagctt atttttttaa cttatagagt aaaatggatt ttttcccttt tggtgtgtag   9721 ttctatgaat tctaacacat gtatagattt atataaccac aaccataatt aggatacgga   9781 actattccat caccccccaa aaattcactt acgttatcct tttacagtca gaccttcctc   9841 ccagcctccc aacctctggc aatcactgat ctgttctcct tcactgtcgt tttgtatttt   9901 tggttcgctg tcattttggt tttttgggaa tgtcatataa atggaatcat acagtatgta   9961 gcagtttgag attggcttct ttcactcata ctgcctttga gattctacca gtgtcccagt  10021 agttcattcc tttttattgc tgagtagtat tacatcgatt gctgaaccgt tcacccattg  10081 aatgacacat aagttgtttc tagttttttg gctattgtga ataaagctac tacaaacatt  10141 catgtacatg tatttatgtg aacataaggc ttcatttatc aagggtaaaa tccccagaag  10201 taggactgtt gggtcatatg gtgagcatat gtttataaga aactgcaaac acattttcca  10261 gagtgttata ccattcaaag ccagttttga acaattcaaa tctatgcttt ttctttccag  10321 taagcbgttt ctccagacga cagagtggtt tactatatta ggcaaagctt catcttgggg  10381 aatgttattt ccaactgaga gctatgggag gcaaagtcac aaaccttcag ctcagactca  10441 ccaatctaac ttgatctggg aagatacctc gacaggtggg ggagggagaa catctgctga  10501 ggaaggccgg gagtggagtg agacattgct acttggaccc caaaaccagg aaaaatttgg  10561 tggttttggt tgagcttgaa ccatcaggtt aaacaggaaa tgcaaaatgc tcttccagtg  10621 aaacagaaga agctgctaag aggtagaggg aacatggaac tatttgtatt gcaaccgaat  10681 ccacctcccc aaacccactg caaagggaaa ttgctgactg caatgtccct gaactccagg  10741 gtgagtaaga agagaaccac gccccccagg gaacacttgt aaatttttaa gcaaatctag  10801 ggaaagttgt gtaaaatgtg tcccttccat aactcaccct aaagcttctg ggtattctaa  10861 atatacaaat tctattcatc acaccgtttt atcaccaagc ttcctgaagg catattgcca  10921 acacaatttg acaaagaaaa tagcaccaac agotttttaa agccttggaa ggatagtctc  10981 agacccatgg ctctctagag gtccagggat gaatctagca aagctggcct ccttttccat  11041 atatatagaa caagaggatt gttaatagca tgggattgga atggctcaag aaaagctttt  11101 tgaagctctt tgagaaaagt agccagggtc cccccttaaa ccttctttgc tgatggcctt  11161 acagctcaaa accagcattg gaaccggcta ggtactccca aaccaaagcc tcttccactt  11221 ggcatgtata tttatattct catatcttct ttcaaatacc tttcagtgtt gccttttgaa  11281 aagattataa tttgtacttt tttgttgaat tcagtaggtt aaagcagtac ctattatctt  11341 taattttatt ttgaaaaatt ggttggtttg gcttttgggg aatttgagag gcaatttagt  11401 ctgtcattta ggatggcatc atataaggca gccaacttca tcatgctatt tagcctgaaa  11461 agcgatattg ttgatcttca accttgaaaa agtcgtacag gttgggagct gacctgcaaa  11521 tggtcaggta tcttgagata ggaaaaggat ttacaaatcc aggtcagcaa gatactcata  11581 caaatatttt gaacccaagg tatacatcaa atagatttaa agactaagac tatttctgag  11641 catgcatcga ctgtttgaag actagtggac ttgtatgaag ttcaggagtt aacctgggtc  11701 ttgtaactta aaaacagcat ttctcatgcc ctaaattagt agtagagaga caatatagag  11761 agttcctata tagccctcac ctatcttcct ctaaggctaa cacctgggaa gttttttttt  11821 aaaaaatcct gatggcaaag ctgcagccca gacccaaaaa atgagaatct gtgagattta  11881 agattcgagc atcagtattt ctttgaagct tattcccagg tagattcaag aagaagccaa  11941 gattttgaat gcctgcttta ttattttttt ttttgtgaga gctttaatgg cacaaaatgt  12001 ttatagctac aagttataca tgtattgtaa attgtatata acgatacaaa gtgctaacta  12061 aatagatgga gaacgcataa ccactttggc tcagttaatc caataatttc cacaatgggt  12121 tcatgaaaaa cctcatctga ctggctaagt cttcaattct cattttttta gaatagtaaa  12181 tatttttact gcaatcacag gaacttgttg cgctttccaa tgtgcaagtt tctgcagttt  12241 tgctcttgat tctatttaca aatatcttaa gccagttttc atcaaacata tgaaaaatga  12301 agcctgcctt tttgtcccca aattgtaaat aggtgtaaat ctttttaagc atcaatctca  12361 caatttcaac agttaattgt tgaattctcc tttccaatac acgatgtttt cgttcaacac  12421 aaatctgggt agtagtaaaa tgttcatccc gtgtgttagg gctacagata catactacgt  12481 gctctcataa taaattttac tgttatgatg tattcatttt ttaagtaatt ttccataatt  12541 tcactgatgc tttaagaaaa agagcaacac tatgtttctt tttaacgttg aaagaaatca  12601 taaatatacc caggttcaat ggcgctactg atagaactgc tgctgaattt ggaatgagca  12661 caatgcacta gctgtaagaa gtcagttttg ggtaatgaat aattttactt ttccctcctg  12721 taataccaat ttcatactgt agcagtttat ctagtcagtt ctcctaactt tctgtccttt  12781 ccaattttat tcaggctttt caaaaatcag tgagccatca gatttacttt cttcccaaag  12841 aaattcaaat atgaatgctt gaaataaata ggttatagaa ggcaaatcaa gtgttatcag  12901 gtttaagatt aagacagaaa catggtctaa taaaaagatg tccaaaatta tctagacatc  12961 aaatgctaga aagaaaaaag aaaattactt gcaaaactat ttaggatata tcatctttct  13021 taaagattgc cagctatatt cttgaaaaaa agataaaaat tttcttgttt aacctgcatg  13081 ttattttcca ctataacatt aattttacaa atgttgatgt gagagagaag agttagatag  13141 tttctgcaaa ctggcaaacc tggctgtgat agtgttttta ttcaagttaa cctggtgcac  13201 tttatagatt gctagottta aaattaacag tgtgaacccc tgotttaaac ccttctcaaa  13261 gtgcagtcag ccaatcaaca gtattgccat cacctgggaa cttgttagac cccactttgt  13321 caaactcatt tcctggtatg acaatgaatc tggctacagc aacagggtgg tggacctcat  13381 ggtccacatg gcctccaagg agtaacaccc caggaccatc agccccagtg agagcacgag  13441 agaaagagag aggccctcag ctgcttggga atccctgcca cgctcagtcc ccaccacact  13501 gaggatctcc tctcctcaca atttccatgc agaccccctg aagagggaag ggcctaggga  13561 gccccacttt gtcatgtacc accaataaag ttccctgtac tcagccaaaa aaaaaagaaa  13621 gaaagaaaaa agaaaaagaa atgcagcatc ctgtcttgcc ccaaacccac tgcgtcagaa  13681 tctgcatttt aacaagatcc ccaggtatgc acattaagtt ttgagaggca gtactacata  13741 taaaatatgc aacagaccac acaaacctgg gcccaattgc tatttgtcag atacatgtat  13801 gtatttatta cttataaatt ccttcatcag atatgtatta cgtgcttatt actttaaaaa  13861 gatgaatctg acacatatcc taccctcaaa gagatctcag tctaggaagg gaaatacaat  13921 gtgttcataa ataatatagt ctaagttagg gacttcataa aatgcttgat ggaagaagtg  13981 gcatttattt tggacctgga atgagaactg aaagaagata ttcaaaagac aagtgatgta  14041 gtgatgtagt tttgaataca cgaataatct cagggttact ttttctatag cttttggtga  14101 atcaagttgt ttattcatac atttaataaa tatttattca gctcttacta ttgctataag  14161 acagatacca ttactgctca ggtggttttt acaacctagt ggggaagaca agcagataac  14221 aagaaatgac acaattcatt agtgttactg gtagcgttgt gaaggacaag gatggggtgc  14281 tagaaatcca tgtgacggac cagacctagg caggggtggg agttatggag gaggtttccc  14341 tgagtaggta acatctaagc tgagaaagat ttagttagac aaagagtgaa tggcattcca  14401 ggcaaaggaa acagcatgga ctaaggtcaa aacaagaaga aatgaacgaa agagcaagtt  14461 gataaaatgg atgtccaata atattccatt gttcaactat gcaacatttt tcattgcctc  14521 ccaaattgga tcaaagtagc ctggtcttca tgcctccagt ccttcctctt tttaaaaatt  14581 ttatacaact atattaatat agaatttaca tactataaaa tttcattcaa gtatattagg  14641 aaatttactg agttgtatag ctatcatcca tataaggtcc gttatgtccc tttgcaatga  14701 accctccatt ctcactccca gcctcaggca gccaataatc tattttctgt ctctaggggc  14761 tggaaactta ggattggaat tagttggttg tataataaat ttagcttatt agagaactgc  14821 tgaactcttt tccaaagcaa caatacaatt ttacagtttc atcagccttg tgtgagggtt  14881 cctgttgctc catatccatt acaacacttg gtattgtcag tccttttgtt tatagccatt  14941 ctactgggtg tgaagtggta tctcatttca ccagcccctc ttcctaactt atttgccaga  15001 ttccccactt ctaaacttgc tctatgccca accaaagtga accccttgct gttttttttt  15061 tcccctgagg ctcgttgata tccccaaatt atgcctttct tcattctttg aatgtgttac  15121 ttgactggat atgtattttt ggtgaaggag aggggctgga aattgagaga tgaaattggt  15181 aggagtacag aaggccgttg acttcctcac aacgtgggac acttccaagt ttctcctaca  15241 aaccccacca ctataccttt ccaaatatct tgcctgccat cttggtcacc cgtgacctaa  15301 attaatactt aggaagctat ggagatgctc atgcttcctc aggggagaat gctgtgtgaa  15361 cttagaaatt agcaaaaggg gaaatgacta cccttgaaat tgtaccacag aaaggagcat  15421 acattcaaat gatggtgaag tcttattaaa aagactttaa gcctcccaat ttagaagctg  15481 gottgtggta gccaagaaat tagagaatga tttgttattt aagagtgaaa ttgctagtag  15541 tcttgaatta attaccataa aaaagctgcc gctgtaataa aaagcagaga tctggtaacc  15601 ctgcttcatt cactttcttc ctcttgatga aaacctttta attattttga ttttgattag  15661 cacttccatc agaaaatagg aagaaattag gagcaattta cttggcaaag gtttagtaat  15721 taaaaccact gaaatcaatg gtttaagtat gtatttggga taaacacatt tttaattgtt  15781 atttttgtct tacccaagtg gataacataa agttcattat acaaaaatca accagtgcag  15841 aaagccgatt gggaacaaac aaccattctt gaaccctttg aaaatgtatg cccttgatga  15901 attacttgtc aggtttctac ttaagtttaa ttgttagtac ttccacttaa aatagcaaaa  15961 tgactgtctg caatttctgt tatttcaaac taggttttaa attctggggt tgaaagtaag  16021 cttaaataac tctgagtact tgagtaaaca ctgcattttt tatgatgagg caagttgtat  16081 gagccattta attactttaa ttcaatccag agatttgata ttttctcctg agttctcaca  16141 gttggatagt ttaaaaatat ttctaagatt gaattgaatc ctgtaagaac tataataaaa  16201 ccatacatct gcctgttttc tttctttctc tttctctcct ttcttttctt tctttctttc  16261 tctttctctc ctttctttct ttctctttct ctcctttctt tctttccttc ttttctttct  16321 ttctttcttt tctttctttc tttctttctt tcctttcttt cttctttctt tctttcttct  16381 ttcctttctt tctttctttc tttctttctt tctttctttc tttctttttc tttttctttc  16441 tttctttctt tctttctttt tcaagatcgt gctccattgc ccaggctgga gtgcaagtgg  16501 cgagatcatg gctcactgca accttgacct ccccaggctc aggtgattct cccacctcag  16561 tctcctgagt agcbjggagt acaggcatgc accagcatgt ctggctaatt tttgtatttt  16621 tagtagagac agggtctcac catgtttcca gtctgatctt gaactcttgg gctcaggcaa  16681 tcctcccacc tojgcttccc aaagtgctgg gattacaagt gtaagccacc atgcctggcc  16741 ttgtattttt ggataatatt gagtgaaatt tgcctcaata cataaaaatc ctttcaatat  16801 gcttcaactc taaaatcttt aaaaagctgc ttggtttcat tattttcacg tggaagcagc  16861 attgtcacaa agttttattt tgaagactga attgtatatg gagtactgtc caactagaag  16921 agaatgaata atcaggaaaa gagagactat tgacaaataa gacttaatgg agaagcattg  16981 aatttcaaag ctgccagaga cattagcaat tgttcagttt catctccaga tttcttagat  17041 gaagaagctg tggcaagcca atttcacaaa cccgatctat gatcctcatg ctccccactc  17101 ctctcactcc cacaattttg ccttgattca aactttatcg aaaagtgaga aatcacaggt  17161 atgagctcac tgagcttccc aggcagtctt gccatctaca aacccatgtc attctgtatt  17221 ttcctcttgt ttctgacagt gatcctctca tctagtcaca ctacatccac ttatctctgg  17281 cacttatgtc aaaacaaccc ctctaggtcc tgccttagct ctcctgcata tgctttttct  17341 ttcttcctgt ctgttgcctc tttcccccag cttataattc tcccgctttt attaaaaaca  17401 tgcacccaca gacacacact cacatctgga ttcccaagtg cgataacctt gtagattcat  17461 attttcagat cgttcttagt ccacagaata taaaattgat tgaatgatgg caaacatctg  17521 cagatgacaa tcatttacag aaatggcact aaagccatga agctgaagct gcaggactta  17581 tggatctggg ctagaagaca ggggccatca aaaatttagc ttcagttgga aatcggctct  17641 tttagtgcac tacatcagat ccatgaaaga ggaaggaaga gttactgctc attgctgcct  17701 ggagctgtga cttctatgaa attacttaac ggggcaaagg aggaagcaga tacttccttg  17761 caactaggac gtgagctgag ctgatocctg aatcataaat actcaacaag attcggattc  17821 aggacccagg gtattatggg gtacaaccat aaaacttcta aatgttggag aaagaataat  17881 gagaaagaaa aatgaatctc tgaatgaaaa tggaactact aaccaaaatt ccaaatcacg  17941 ttaatataat tattactaag aatgacagca acaaaatgaa taatcagtat atgtcatacc  18001 tataaagtta aaatctaaaa taatttgaag aaatacttaa aaatatttgc aaccctcaaa  18061 gagataaaga aataatattc ataaaattga aatgacaaac taggggcagg gcgcagtggc  18121 tcacgcctgt aatcccagca ctgtgggagg ccgaggtggg tggatcacaa agtcaggaga  18181 tcgagaccat cctggctaac acggtgaaac cctgtctcta ataaaaatac aaaaacaaaa  18241 ttagccgggc gtggtggtgg gcgcctgtag tcccagctac tcaggaggct gaggagggag  18301 aatggcgtga acccgggagg tggagcttgc agtgagccga gatcgcgcca ctgcactcta  18361 gcctgggcaa cagaatgaga ctgggtctca aaacaaacaa acaaacaaac aaacaaacta  18421 ggaagaatat acagaaatgt aacagaaagt agataggaag aagaatgaag tagaaatgct  18481 tgaaattaga aatacggtga ttgaaattaa aaccttaaca aagtaaactc tagactcaca  18541 acaattggag agttggtgat tggaaagatg aaccaattaa tttacccata acacattaga  18601 gagaggtgaa gaggaaaaaa tagctaaata taaaagcaca tttaagagac atgtaagatg  18661 attaaaagcc tccaacattt ttcaaaaaag agagtagagg caatattata ggtggaataa  18721 tgaaaatgat aatggctgag aatattaaag aattgagaat aaaaaagaca agtggcctca  18781 gattgaaact gccatgaagg tctctgtctc aaattctcaa ctctgctttt gtagtatgaa  18841 agcagccgta gacaataagt aaatgaatgg acatggctgt gtgtcaatac aacttgattt  18901 acaaaaacag gcaggcagca ggctaaatta ggcbgggagg tcatagtttg acagctcttg  18961 atctaaagaa taaccattgt tggccaggcg cagcggctca tgtctgtaat cacaacactt  19021 tgggcggcca aggcgagcag atcacttgag cccaggagtt caagaccagc ctgcgcaaca  19081 tggcgaaacc ccatctctac taaaagtaca aaaattagcc gggcatggtg gcaggctcct  19141 gtagtcccag ctacttagga ggctgaggca ggagaatcgc ttgaacctgg gaggctgagg  19201 ttgcagtgag cggagatggt gccactgcac tccagcctgg atgacagagc cagactcggt  19261 ctcgaaaata aataaagaat aacctttgtt tacattttca tgtatatgtc tccagatgtt  19321 cctcatatat ccatataagt atgtatatat gatgtacata agtgcataag taaaaataca  19381 taagtaattt taaaagaggt tatatcatag ctgaatcaca catgacttag accacacttg  19441 ctcttctgag tacccatttt tggacaactc tcagtgtcca ctagcatgtc taaaaaaaat  19501 ttctcctcct aaaatgctaa tgcatgatgt agattttaac tacagctttt gaggctcagt  19561 ggaggagagt gtacatcaca ctacccaatg caaagccttt taacagcccc ttttgctcat  19621 ctttgttttc cttcactgtt cctcgccctg cagcaggcag ctgacattca cctttccctt  19681 ccaccctcct ctctcagcac tggtcctttg cctcctccct catcccagct ctacaaatgg  19741 cctcagcctg catattccaa ccacccagca aaacaaacat ctagtaacta ccgggtcagc  19801 aagagaaaat cggaggccct agccatagat agatcacctt atcatttctc cagcacattc  19861 caggaaggat ctcaattcgt tctgtcccaa tatacctcta catcctttgt tttgatgatc  19921 acatagaatt cattgtatgc atatatcatt atttatataa ctaagccccc aattttgaac  19981 aagaggctac atactgaaaa tcttttatct accaagtctt ttttttctta caaacccatc  20041 caatacagtt gcactgtatc cgccaataca gttcatgcaa ctgtatggaa agcaaactct  20101 agaagagtat ttgatagctc cataagaata ttaaactctt atacttctag agcgtaaaac  20161 cccagaaaag tattttgtca gaaaaaaatc atgtttttga aatagtaggt tttaaaagaa  20221 aacaaagaga gttagaagta agaaaattca ggttatcagg ggcttgatat cttttttttg  20281 tgactgtagt caggttaccc aggcctttgt ggatcaattt ctcaaacaaa taacagagat  20341 gaaaacaact gtcagtagct actgtcacaa aaataatatg ataaacatct tttcgtttcc  20401 tatggctgcc ataactaatt atcacaaact tggtggctta aaataacaga aatgtatttt  20461 ctcacagctc cagagtccag aattccaaaa tggaagggtc agcaaggctg cacgccctca  20521 aaacactctt ggagagaatc ttttcttgct tcatccagct tctgatggct ctaggcaatc  20581 ccccgcttgt cactgcatca ctcoggtctc tgcccccatc ttcaaatgac cttcctctgt  20641 gtccctgtct tctcttctgt ctcttataag gacacttgtc attgtacagt atttagggtc  20701 cacatagata atccaggagg atctcatttt aagatcctta acttcattac atctgtacag  20761 atcctttgtc caaattaagg taatgttcac aggttctgtg ggttaggatg tggacatatc  20821 attttgaggc ccaccattca atgcactaca attttctttg taagtgttct gagaacccag  20881 gaagaataag taaatcctct gattcaatca aaaatgagca gaatgtaaac caaaaatact  20941 agaagatatc ctttttccta ggcactggca tacgtttcaa tagtatctct aattacagat  21001 gtatttacac ttctaagtgt cagaaatgaa gattattatg acaaatttaa aatttagtaa  21061 cttgttttta aactggtatt tttgtttttt taagcgatca tctcagtcca cattggaacg  21121 atctgaacag cagatcaggg ctgcttctag tttggaggaa ctacttcgaa ttactcactc  21181 tgaggactgg aagcbgtgga gatgcaggct gaggctcaaa agttttacca gtatggactc  21241 tcgctcagca tcccatcggt ccactaggtt tgcggcaact ttctatgaca ttgaaacact  21301 aaaaggtagg tgtgtggatg tggagacaaa ttctttctct ttattagata gtgacaaaca  21361 cacttacttt ctccaaaagt ctgcgtaggg cagacacgtg tcagagggag aatgaaagtc  21421 ggtctttgat ttccagtatt agtgcagaat cttgattttt taatgtttac ttcacagaga  21481 aatatattca atatgatttt gagataaaaa acacaaaaga acatctcaaa atatagaaat  21541 aaatttaact caaggatgtg ggggcaaaga aaacccagga agactattgt tctcaataga  21601 aaaacaatca tcaggtttac ttagaaaata aaacctgggg attcatccac aaggagtatt  21661 ctactgccat acatacatag acaaaaacca aagatggcca ggcatggtgg ctcatgcctg  21721 taatcccagc actttgggag gccaagaacg gcagatcgct tgagcccagg agtttgaaac  21781 cagcctgggc aacatgacga gaccccatct ctacaaaaaa atagaaaaaa atagctgaac  21841 attgtggtac gtgcctgtat tcccagctac ttgggaggct gaggtgggag gatcggctga  21901 gcccaggagg tcgaggctgc agtgagccat gatcatgcta ctgcactcca gcctgggcaa  21961 cagagcaaga tcctgtctca aaaaaaccac cccctccccg aaccaataga ttaggtatag  22021 cttttttttt tatttctgca aagttgtgtg attttttagt aaaagtgaaa agtaaaagtt  22081 agacactgag ttgtaatatt gggtactggt attgctagga gaataatgaa gggagaaaat  22141 tctcaagaca aaatgatcaa aactccagac tagaaaataa cataatttga aataaggata  22201 atgatcgttc cctagtaacg tatgaagatt ctttaaaaga aaatcaggcc aggtgtggtg  22261 gatgacacct gtaatcccag cactttggga ggttgaggca ggtggatcac ctgaggtcag  22321 gagttcgaga ccagcctgac caacatggtg aaaacccatc tctactaaaa atacaaaatt  22381 agccaggcat ggcggtgcat gcctgtaatc ccaactactt gggaggctga ggcaggagaa  22441 tcacttgaac ccaggaggcg gaggttgcag tgagccaaga ttgcaccatt gcactccaac  22501 ctgggcaaca agagtgaaac tccatcttaa aaaacaaaaa aacaaaacaa aacaaaacaa  22561 aaaaacaaag aaagaaagaa agaaaaccag tgtgagtagg tactgtcata atgaataaaa  22621 tgcttgtcaa gtaaagttct gtggtttctg attaggcact taattttttg atgtcatgtc  22681 aaaacaacac aagaagctgc tacagcattg ctgatctagc attctagatt tgattaacat  22741 gattacctgg taactgacta tatatatagc ataattcaaa ttaaccacta ggccaaaact  22801 atttttttct ttctacctaa aattgtattt gttttttccc atttgtaaaa agatgttggg  22861 gttgcacaga cctctgttgt tggcbgtggg gagagctgtg catagatggg gacatattct  22921 ttggtagcac cttgggcatg agtgtgaaga ggattcttag tgttcatgtg tatgactgtg  22981 tgtctaagtg agttgatgtg gtaggaacca tagcctcgag ctcacttcag acagaaattt  23041 gaagctctag atgtttctat gtggtgaatt aatatagcct tcatgagaac aaagggttgg  23101 cacctcatct agaggtcaaa ggccttaacc agattacctg actgaaggcc tgaggtgaac  23161 ctggagctat ttcatgaaca tgaacgttac cataaaacca agactaggtg atctaaaaaa  23221 agtcaatgac attgacattt tctaaggaga aaaccattaa aatatcacgg aatttgcaaa  23281 ccctatgaat ttatctcgta atttctaggg gatcatctga agttatttac taagttagaa  23341 gcagtcaata atgaaatcag catgttacac caattagaat ttgttatcaa ctctcccttg  23401 tggatttcaa ggtaatttcc tgaggcagag cagtcctgct gggaagcagt aaagaatagt  23461 agagttatga agcctttaat cagtgatgtt ggtcataatt gcatatgatt ttgattaaaa  23521 gcttaccact ccaatttcaa aacttagttt tataaaaaga gaaaaagcaa atggaaagca  23581 acctttaagt agaattttaa attgggaata ttttcatagg ttggtttctt gttttttcaa  23641 ggattcatga ttaattatag tgaattaaat aataaccata ataatactta attgagtaat  23701 ttatctctca bitgttcagc cttcaggctt tttatataaa tattaataat cagaaatttt  23761 taaaaaggtt tcttgggggc tgggcacagt ggctcacgcc tttaatccca gcactttggg  23821 aggctgaggt gggcggatca caaggttaag agatcaagac cagcctggcc aacatggtga  23881 aactccgtct ctactaaaaa tacaaaaatt agctgggcat ggtggcgcat acctgtaatc  23941 ccagctactt gggaggctga ggcaggagaa tcgcttgaac ccaggaggtg gaggttgcag  24001 tgagccgaga tcgcgccgct gcactccagc ctggcaacag agtgagaccc cgtctcaaaa  24061 aaaaaaaaaa aagtttctca ggatagaatg ttttattatg aggaaaaaaa taaaaaaaaa  24121 caaagtttag gtagactgtg tagtataatg cagtgctcca gacaactcat attatgtttt  24181 cagtgattga agaagcaaca tatgaaaaaa attggtatta agggatgaaa aaggagaaag  24241 gaatggagaa gatgttataa gggaataatt tagggactag ggtcacatct caaatggtaa  24301 tattgtatca gtatacttca agcagacgtt ttctctattc cttctattcc cctatatggg  24361 aattcaggat aatctcagga gagttcttga aaatgcagta aaaataaagg agagtttgcc  24421 tattgttgca taacacatta ccacaaaact tagctactta aaacaatatt tatctcagtt  24481 tctgtgggcc agaaatgctg acatggccta gatcagtttt tctgcttcag atgtctctgg  24541 aggctgcagt taagatgttg gcttgggctg caggcatctt agggcacagc tgaagcagag  24601 tgtgctttca agttcagtca gctgttgttt gcaggactca attcctcaca ggctgttgga  24661 ctgagggtct tagttcctcg ctggctattg gccagaggct gcctcaagtt ccttgtcgtg  24721 tggacctttc taacatggcg gcaaactaac acaagaactg aaaaccaaac accgcatgtt  24781 ctcactcata agtgggagtt gaacaatgag aacacatata cacaaggagg ggaacatcac  24841 aaaccagggc ctgttggtgg gtggggggca aagggaggga gagcattagg acaaatacct  24901 aatgcatgcg gggcttgaaa cctagatgac gggttgacgg gtgcagcaaa ccaccgtggc  24961 acatgcatac ctgtgtaaca aacctgcacg ttctgcacat gtatcccaga acttaaagta  25021 aaataagcta aaaaaaaaaa aaaaaaaaaa agcctgcaag tggagaagga ggagagagag  25081 agagagagtg tgtgtgagaa agtgagacag agtaagaaag aagggagctt gcaataagta  25141 gaaacaagac tgcaatcttt tttaacttca tcatggaagt ggtatcccat cacttttgct  25201 gtattctctt cataagaagc aagttactag gttcagctca cacacgaggg gaaggcattt  25261 acacaagggc atgactatca ggagatgggg accactgggg gttagtttca aagctgccta  25321 ccacaagaga ttttcaccag caccacaacc ccacacataa taaataaact ctacagttcc  25381 atggcaagct acaaggaagt ctttgtgttg tctttatcat aaaattgaat ctttccccca  25441 aaacacctgt agaaaggcta tgcagcatta agtatcaaag ggtcaaaatc taatttaaaa  25501 aataaattat gagagaaaag caagtactgt tttacaagaa agtatataat ttttttattc  25561 ccataggctt ctttttttgt taccttcaaa ttaactatgg tcaaaggatt gctcattcca  25621 gtaataagaa caggcttatt tcatcattta cataaatatc agtatcgggc acttgcaaat  25681 gagaaaactc tgatttgagt aaggattagt ttcacttcaa tttccattta tgcgtttgcc  25741 aagtttaaat cctactgtag ttacttaagc aaccaacaga aacatatttc ttgatgatgc  25801 taaaacctac ctacacctgg ctttaaagca gaagaaatgc tatccagctg tatcctataa  25861 attgcttgat aaataatatt tacatgttat ttctttacac gcttctattt acttccctat  25921 taaccagctt ctccagatgt attcagtgta attatgtaca ggacatggtg ttctacctca  25981 aagggaaata aaatacttat attctacaag gtatggtata aatgggaaag agcacagaga  26041 ttggttgtaa cttctctgca aacaatcttt ggttaaagga ctgacaaaaa atatccatct  26101 agtaaaagaa acaagcagta gaaatgtgaa aatgactgtg ttcagcataa ccctggcaca  26161 tgttggcaca ccaggaccat tccacctgct agccccagtg agctttcttt ctctctgcag  26221 ttatagatga agaatggcaa agaactcagt gcagccctag agaaacgtgc gtggaggtgg  26281 ccagtgagct ggggaagagt accaacacat tcttcaagcc cccttgtgtg aacgtgttcc  26341 gatgtggtgg ctgttgcaat gaagagagcc ttatctgtat gaacaccagc acctcgtaca  26401 tttccaaaca ggtataagga catcggcaag cctgccgtct ctaaagccct gatgataata  26461 gtgttgatag ctacaacaac cttgttgcta aacactgtac taaatgcttt atgtgcataa  26521 tcgcatttaa tctttgaaac aaatcaagag ggtattttat gctcctttat agatgaggaa  26581 actgaggctc agagaggtaa cttacttatc caagtttaca cggctgataa atagcagagc  26641 tgggattcaa acccaggtct gtgggaggcc agagcctgaa ctcttatcag ttattgtctc  26701 tctgatgcta tgatgtcaag actcagaaaa ccatatggaa gttactagga caggatgtta  26761 aaaggaatga agatagctga tggcaggttc tgtgttgctc aaatggagtg attgagaaaa  26821 atttaatgaa ggttgtgggc agaattgggg aaagagggat gggacagtga agcacctgaa  26881 gctagcaaaa agggtgagat ttocccaccc ttcgactgag gagacaaggg gagggagcag  26941 ttatgggaac ccagagggaa agcggagaag agggtttctg gactggccac tgtcaactct  27001 tagcctggca gggagtaggg gcaggggctg ggagaggcaa gagggtttat agatgtagcc  27061 catggagggc agcgtcctgg ggcacagagc ctgatgggga aggaagggga gaggatggtg  27121 tctctggagg ggcaaagaga gaatatctag cacaaaagac atttggaaat aattctgcag  27181 tccccatgaa agaaataatt cagccctctt catcttataa atttcccttt gcttagtagg  27241 taagttttcc tttctctggt taccatgttt ttaataaatg tcgcatatga gagcagtagt  27301 aacaaacttg ggaaagcaat actaaaaaac tgtacatcaa actacattat ttttggtatc  27361 bittgcaaat tctttgaatg ttgatatact tatttaattg tcagtttgcc tatatggttt  27421 attctccttt taactgcaaa aagaggtagt acaagaaaat tacatgcact gaatatatcc  27481 atgttaggta attttcttaa tgctgatttg ttttgttaat agatttactt atccttaatt  27541 ttgttcctcc accctctaaa atatccttta aactgcagag tttctttttc taaattcttt  27601 tagagaatct tggagcttgt gtgtatttta acctctacta tttgacaatt aggaaaaaaa  27661 aatgacccaa gtagggctaa gcatcaattc tgagtagaaa aaaagcttgc ataacgtaag  27721 agggtttagt tcatgatcat gtgattccct agagcatagc caaaaaattg tgcaagaaga  27781 tgaagtttat gcaaagtaaa cactacaaaa acactctcac tgagactcat ggaagttcca  27841 ttacatattg agatgtcaga ataaacacaa ccttaatgga ttgcttccac ttaatagata  27901 gttgagtact ttattttgac tgctgtactc aacaaatgat taatttcata caatgtactt  27961 aagtgtaagt gtacagcagt ttttcttcca aatatgcatt tttgaacatt ttaatagtag  28021 ttttttaaaa actatctctc gccccaaagt tatggactat ttggcaaacc acctcttaga  28081 aacaaagtga acaaatgaat actctatgta gtaaggacta catggaatgg tgattgaata  28141 gacaatgcat taaaatcaac ttcaaactca tccacacatc atagaaccac tcaagaaagt  28201 tgtgtaatct ctctgtacat ctgtttcttc acctgtaaga tggggataat aaaaacccac  28261 cccataatgt tgttataagg ggtaaatgag ttaacatgaa agcacttaca acagggcctg  28321 gcctacggaa agcgtagaaa gaatgatata catgttagct ataattattt gtttgggcat  28381 gatgatcttg tatcagtcag ctattaatac acagtgctac gtaacaaaca cactaaaact  28441 cagtggttcc aaacaacaat gatttactct cacttatgta tctgaggttc agttagttta  28501 gggtggattc agcbjggctt gactctaagc tgcagtgtga gtccaagtca acttctatgt  28561 ttcccatcgc ttggaccagc aagcctgccg gattatgttc ttttcatggc tatagcataa  28621 gtttgagaaa acaagcccca taaaacatgc acagttcaaa tttgtacttc tgtcatgtct  28681 gctaacatcc cactagccaa agaaagtgac atggccaaat aaaaagtcaa gagacaggaa  28741 actatatttc ttcaatagag atggtgtgag aagggatgaa taaatagttt gaataataat  28801 ctattctaat aaaatcctaa agaaactgca tagctttaat ctcatttaac ccttacgatt  28861 tacactcaaa tttaaagcag gagcagggat taacagtacc attttacaag agtatcaatg  28921 atcaaaaagt taaaagattt gaccaaactt aaacacttca taaagttaga tgagcctgtt  28981 tagttccatt cttaatggac aacttggcta aagtcattgc cgtaaatgac aaaggcaaaa  29041 attcagacta gaacaacttt aaaaatgata tataaaatta aaaaaatata ttgtggttat  29101 ctttctctgc tgtagctctt tgagatatca gtgcctttga catcagtacc tgaattagtg  29161 ccbittaaag ttgccaatca tacaggttgt aagtgottgc caacagoccc ccgccatcca  29221 tactcaatta tcagaagatc catccagatc cctgaagaag atcggtaagc acttttgttt  29281 ttttttttat actggattat gcttattttt gccttgccaa aactgtgtgt agaggatttt  29341 tcattaatgt agagttatca atttatcttc aaattattca tattttagct tctaacctga  29401 acctactggt aataactggc aaatacatat ttttattaga tgttagatat atattgtggt  29461 aggaccaaaa cgctcagtgg tatgagcttg tcatgtctac ttgtagacac gtttgttctt  29521 aatatgcata gtctactgca ggtgtaaaac cgctgtaacc tcaaatttag cacatgttcc  29581 agaacaagca ttaaataaaa cttatttcag gcbgtttgta tatttacatc ctgaaatgag  29641 agaaaacaaa gaagattcct ggggtcattg gggagtgaca aaactagcag cacgtgagtt  29701 ttgcaacttt ctaatctttc ccccttaaga ttaccaaatg gaaaaccctt attttaaatt  29761 aaaatgactt aaaattaatt tggctttgaa attctcttga gattaatttt gtgattattt  29821 ataagacaaa cgacaaaacc aaaggtaagg atcacttatt tgaagaaaaa aaaggattta  29881 atataaagaa acaagtaaag ggtaactgaa tgaaaagatc attagttaga tacttagact  29941 ttgcaaaagt aaagcaataa atatattgtg tgagtggcaa gtaaaagagt aagctggtga  30001 ttagttaaca ttgaaccaag aagacacctc ccgcctctct ccagcagaaa agaaaacttg  30061 tagaaaagca acatttattc tcaagatgtt cctgcbgttc tggccaatgc ttttatcttt  30121 attttaaaga aaataatctt aggggccggg cacggtggct cacacctgta atcccagcag  30181 tatgggaggc tgaggcgggc agatcacgag gtcaggagat tgagaccatc ctggctaaca  30241 cggtgcaact ccgtctctac taaaaatata aaaaaaaatt agccgggtgt ggtggtgggt  30301 gcctgtagtc ccagttactt gggaggctga ggcaggagaa tggcatgaac ctgggaggtg  30361 gagcttgcag tgagccgaga tcgcgccact gcactccagc ctgggcaaca gagggagact  30421 ccgtcaaaaa aaaaagaaaa gaaaataatc ttaggaggta tgttagaaca tatttaattt  30481 tcgtaaataa actgttgaca gctataattt gcatagtttt aacatatacc ttcttaagaa  30541 gattacaatt tccaaaatta cagtttagtt tctaaacatt tccacgtaga atatttataa  30601 ttacagaatc actatctagt aagatgcagt tcataaatac aaattaagct cctttaaaat  30661 cttttttttt tttgagacgg agtttcgctc ttgttgcccc ggctggagtg caatggcgag  30721 atctojgctc actgcaacct ccgcctccca ggttcaagtg attctcctgc ctcagccttc  30781 caagtagctg ggattacagg catgtgccgc cacgcccggc taattttgta tttttcagta  30841 gagatggggt ttctccatat tagtcaggct ggtctcgaac tcccgacctc aggtgatctg  30901 cccgcctcgg actcccaaag tgctgggatt acaggcgtga gccaccgcac ctggcccgct  30961 cctttaaaat cttaactctt ctcacatcct tatcattttg tggtgagaac atttgaaatt  31021 tactctctta gcaatttgga aatataaaat acattattat tattgactat agttaccatg  31081 ctgtgcaata gatctcaaaa ccttatttct ccaaactgag tataaaaagc aaaaaataaa  31141 tttaaaaaat cttaactatt atctactcag gaatttattt aatgttccaa agttttgatt  31201 atccttgaaa gcttttaaat ctggttcatt gttttctttt cctagcbgtt cccattccaa  31261 gaaactctgt cctattgaca tgctatggga tagcaacaaa tgtaaatgtg ttttgcagga  31321 ggaaaatcca cttgctggaa cagaaggtaa tgatagtagt agtaaaataa taacagtaat  31381 aataaaagta gcaacaatag cagcaaccgt tattgagtac ttagtatgac cagacaatgt  31441 tgtaaatott gtatatgttt taactcattt aattctcaca acaaccctgt aatgtactat  31501 tgttatttct ttttttacaa ttacaaaatg ggcacaccaa gatatcgagt aatttcctca  31561 aggtcacaca gctgagagtg atagaagtgg tcagattcca gaaccctctg taccataatc  31621 atatagtaag tccatcaatg catcactctg ctttttaatc tcaaagaaaa gcccagagtg  31681 gttggagcat cctgaaacac tgaaattgaa aggggatgtt aaacttgaat gaaagctgct  31741 tcagaactaa atactagtca actgcagttt actaatttat ttgtataaaa gtctcacagg  31801 aacataaagt aattttggac ttggtttctg tcagctgcat catatgaaaa cacgccagta  31861 atttgaaaaa agaaatggag aataagagaa aatttttctg gaattagggc aaagcaaaag  31921 caaaatatgg ctattggtct aaggggagct gggagcaaaa tgagatatag tcaaattgtc  31981 attgctcata atccgtaatt ctgtgacttt gggtgatgaa catttgcttg aaaatgaatg  32041 cattttaatg tattttccag agagctttac atggttccac caaaaaaaaa aaagaaagaa  32101 aaaaaaagtc acaagtagtc atgcagtttt aaccttgctt gttttaaact ataatctata  32161 agcaagaaca gtaagggcta aactctaaga aatctgtcct ataaactgta aatagcaacc  32221 tactctccat tcttctgcct ctcagcttcc ttctaaatgt tttcacgaaa gctcagccca  32281 gagcatgtgg ggaaatttaa tatttatgtg gtttaaatgc ccatgccgat cttgaatgtt  32341 ctttacaccc ttcccaccaa gtgttcagcc atcctctacc agaacataca tcagttattt  32401 ggagactcgc catccagtga ggcagcacca aggggtgggc acactcctgt tgttatactg  32461 aaatgaaatc tctctccaga acagaccaga ctgcccaatg gaatacaata agagtcatat  32521 atgtaactca cattttacat taaaaagata aaaagaaaca agtgaaattt atcttaatat  32581 attttattta atccaatcta tccaatgtac tatcatttca acatgcaatc aatataaaaa  32641 atttatgagc tagcctacat tctttgtgct aagtctttga aatccagtgt gtgttgtaca  32701 cttacagcac atctcaattt agactctcta tttcatgccc aatagtcaca tatggcccat  32761 agctaccttg ttggacagcc cagctcaaga gcatcaactc attagttcag gttttaccct  32821 atagaaccat gtaaaacaaa tctaattctt tctccatgtg actcatgttc taaaagtgtt  32881 agaaaatttt tgtggggttg gccgggaatg gtggctcatg cctgtaatcc tagcactttg  32941 ggaggccgag atgggaggat cacttgaggt tgggagtttg aaaaccagcc gggccggccg  33001 ggcgcggtgg ctcacgcctg tagtcccagc actttgggag gccgaggcgg gcggatcacg  33061 aggtcaggag attgagacca tcctggctaa aacggtgaaa ccccgtctct actaaaaata  33121 caaaaaaaaa attagccggg cgtagtggcg ggcgcctgta gtcccagcta cttgggaggc  33181 tgaggcagga gaatggcgtg aacccgggag gcggagcttg cagtgagccg agatcccgcc  33241 actgcactcc agcctgggca acagagcgag actccgtctc aaaaaaagaa aaaaaaaaaa  33301 aagaaaacca gccgggccaa catggcgaaa tcccatctct actactacta aaaaaaaaaa  33361 aaaaaaaaaa aaaaaaaaaa aaaaaatagc tgggcatggt gatgtgcgcc tgtagtccca  33421 gctactcagg aggctgaggc atgagaatct cttgaacctg ggaggcagag gttgcagtga  33481 gccgaggtca tgccaccgca ctcgggcctg gatgacagag tgagactctg cctccaaaaa  33541 aagaaagaaa gaaagaaaga gagaaagaga aaaagaaaag aaaagaaaga gagagagaga  33601 gaaagaaaga aagaaaagaa aagaaagaga gagaaagaaa gaaagaaaag aaagaaaaag  33661 aaaggaagga aggaaggata gaaagaaaga aagagaaaga aagtaagtta ctgtgggaag  33721 ggcaatatac ttagagctta aaggctctag ctgaggattt cctggcacaa agcctctgag  33781 acagttttgt acggaggagg tttgtaggca ggcacaaggc attaaagggt aaagagagag  33841 gcagcagacc acagcgcagt tgctaagagg catcagccta agccaatggg aagttgaagc  33901 tgggaacccc tgcgggggta agtcttaaat ctaggtgaag aggctgagcc ctgtagaccg  33961 ttcattggct gccttggaga ggggatgtag ccttaggaga ggcagcttat ttctgctgga  34021 gataattctt gggaaggcac tcagccagta cacgtgtgta gagggtggta agaagaatag  34081 ggaagaagag aagtgctgtt ctaagcagcg ggtatatgag cactcagggc tggaggtgag  34141 agaacatact ggaagaagtt cagcatggtg gggatataat gggtggggac ataatgggga  34201 aggggctggt tagatgtgag agaagaagct ggacaggctc acaggggcaa agcagaagga  34261 ccttgtaatt cttgcatggg agcttggatg tgatactaag gacaaaggga aaccacacaa  34321 ctggctaaag caggagagtg acagtaccca ttagaatttt aacaaaatca tatcagcaac  34381 agtgtagaag aggatgtgtt gactcggggc agggaaggag gcaggaaacc ttttgggaag  34441 ttgtagcaat gatgtaagtg agaggcgcag ggtggactgg atcacaattg tttctcattc  34501 tcatctccta taagtcccca atgtggatca agttcacatt catttctcca gtggccccat  34561 caaattgatg ggatttactg agcttactgc tcactatact ttttttccgc acatgtgact  34621 gttaagccaa ctgccttttc tacagtgact tctcttgccc agatgagcac atttaggtta  34681 gtgaatccaa gtctaattta attgagtctt gttagagtca ggtcattgct ctaaattgtt  34741 aaaacaaacg atatacacaa acacacacac acacaaaaga ataaattgag gaggtcccaa  34801 ttctgtattt taaaatactt aatatatccc ttccttcttg aagagagcta caatttcaag  34861 aatttatttt gaaaaaattc tatcagttta ttgataaaaa tggtaaaagg aacaaagctg  34921 agaacagaac atatcatcag actctctagg gacggaaatc aatacataat acttcaagat  34981 atcaccctca gctacttgct gttccaccac cagttctctt gcatccagtt tttgtttctt  35041 ttaacttggc tataaggatg tgagcacaga ctctgccaaa cagcctgctg aagttctgca  35101 aacaccttgt ggattgtgtt tccctgaaca accctgtcca acaatggcct tgggcctgtc  35161 tgaagtattc ttagtgaact tctgctgcca cctagtgatc attgcgaatt tttaaaaagc  35221 ctctttatcc tttaacaagt tactcttgtc ttaccccaaa gcggcatctg cctcactggc  35281 atatgactta cagagctcac attttccctc tccacaaagt tcaaaatgga gacttctcag  35341 atttagcctt ccagcaccca ttctcaaacg tcgtgcatta cagaaaagtt taaactataa  35401 agttgaaccg cacgagattc tcattttgat atgtcattaa agtcagatat tggcaagaac  35461 atatggttta acccaatggc ttggaatgct ggatgggatt cccagaagct ccatacatcg  35521 gcctgcttca ggaccctttt attacaccaa ataaacccaa caaacatcca tcgagtgcct  35581 attttatatc agaacaatga gacctgctcc ttctccttca ggacatttta cttaatgggg  35641 gaaacataca agtaaacaga caaatgtaat cagtgcaaga aagaatcgga cagcaatatg  35701 cacaggataa ggacacttag ctaaacctgc agacattggg aaagatgtca gggaaaaggg  35761 atggcagaag gaaagacaag gccaaaggca tgggactggg aggcactgga atatcagggc  35821 aacagaaagt gctgtcattt ggtataaatg gaacacacag gatatatgaa agcaagaaac  35881 agaagatgag tctgtgaggt tactatgatc cagttcatgg agggccttgt atgtcctggt  35941 gggaaaattg gtttttattg tgggaaggga accttttaat gcattcaaag cagtggaatg  36001 aagtgatttg gtttgcattt gttaatcatg tgaagaagaa taggttggag ggataaaact  36061 tgtggtggtg agatgagtga cagagcgaca gccatctaca aaagaaacac aaggtacaga  36121 ctgaattgtg ggagtggtag tggggatgga aaataaagaa caaatttaga gaggcagaac  36181 tgagtggaca tgatgctcag acttaccaga gcaggtgagt caagaatgat gtcaccattc  36241 cctaaatgag gcaaactggg agagaagcag atttggggag aaaactacta aacatgtacg  36301 tccctccaaa accttcaaga atgctaaagg gacagagtca agttcttcca aagtttctgt  36361 ctcttccatt tattttgcaa tgaatttcaa cttgttaatc agaaatggat ttggagtagt  36421 agctattcaa ttgttttata caccttctag aagaaatatt tgtcagatga gtatgtcaaa  36481 aacttctcag accctcccct ttacttgaat gtatcttcca gcagatgttg gtggaatcaa  36541 agttcattat tactcctata tcttttatac tagtgttatg atctgcagtg aggacatgca  36601 ttgctattgc tacgcctggc ctggaatgtc tgaggtgtat ttctacaaca ccaattattt  36661 tgtgtgtctc tccttttaat ctccaccaaa aaatggagac agctagattc ataaccctta  36721 gacatcctat attttattac taatacttgg ttgtggaagt ttgcattcta aacaagtcat  36781 caacataaaa atctctaaaa atattttatg aaaaatattc agcttatgat attttaaaaa  36841 tcacaaacct aagaaaacac acaaacctgt gtttgtattg tgaaatcaga ggttaatctt  36901 cctcaccctg tgaaaaaatt aggggcataa atctatagga aggagattgg gtgaatccaa  36961 gttacttacg gatgacataa aagatacaat caactttggt gatccaattg ccacactaca  37021 actatctgac caacacgttt ctgtttctct ttagaccact ctcatctcca ggaaccagct  37081 ctctgtgggc cacacatgat gtttgacgaa gatcgttgcg agtgtgtctg taaaacacca  37141 tgtcccaaag atctaatcca gcaccccaaa aactgcagtt gctttgagtg caaagaaagt  37201 ctggagacct gctgccagaa gcacaagcta tttcacccag acacctgcag gtaaatgcct  37261 tgagttgtct tgcctttact catgacattt aacgtagatg ccattttaat ttggtgggat  37321 tccttagtaa gctaattttt ccccttggtg cctgagtccc ttttggataa tagaacagag  37381 gtttagcagc taaggaataa gcaagagtat accgagtcat gattaatcat gaaaataaga  37441 aaatcaatcc tgcctgttat tatgtgtgta gagctttttt tttttagacg gagtctcgct  37501 ctgtctccag gctggagtgc agtggcgtga tctgggctca ctgcaacctc cgtctctctg  37561 gttcaaggga gtctcctgcc tcagcctccc aagtagctgg gattacaggc acgtgccacc  37621 acacccagct aatttttgta tttcagtaga gacggggttt caccatgttg gccaggatag  37681 tcttgatctc ctgacctcat gatccacccg tctojgcctc ccaaagtgct gggattacag  37741 gcatgagcca ccgcgcccac cojgggttta gagctcttaa acaacaatga aattggtaaa  37801 atttaagcag ttattaggat attgcttaat aataatattt taggaagggg aggtttcaga  37861 tcatcaacct gtttagttca atctctcatt gtttatgtct atatatgttt gtttttttct  37921 ttaatggagg gaatatcatt ggatttatat agcaagtaat ttattcatga atagaacact  37981 tggaggttac tgattcactt cagtagattt tgaatccatg tgggataacc atgcaggatt  38041 ttatactgac attttaaata catgtctgga aaacttaatc aaatcagagc agagttattc  38101 ttttgaatcc agtcattgat tctgaattct catctttatt ttcttttgca acagctgtga  38161 ggacagatgc ccctttcata ccagaccatg tgcaagtggc aaaacagcat gtgcaaagca  38221 ttgccgcttt ccaaaggaga aaagggctgc ccaggggccc cacagccgaa agaatccttg  38281 attcagcgtt ccaagttocc catocctgtc atttttaaca gcatgctgct ttgccaagtt  38341 gcbgtcactg tttttttccc aggtgttaaa aaaaaaatcc attttacaca gcaccacagt  38401 gaatccagac caaccttcca ttcacaccag ctaaggagtc cctggttcat tgatggatgt  38461 cttctagctg cagatgcctc tgcgcaccaa ggaatggaga ggaggggacc catgtaatcc  38521 ttttgtttag ttttgttttt gttttttggt gaatgagaaa ggtgtgctgg tcatggaatg  38581 gcaggtgtca tatgactgat tactcagagc agatgaggaa aactgtagtc tctgagtcct  38641 ttgctaatcg caactcttgt gaattattct gattcttttt tatgcagaat ttgattcgta  38701 tgatcagtac tgactttctg attactgtcc agcttatagt cttccagttt aatgaactac  38761 catctgatgt ttcatattta agtgtattta aagaaaataa acaccattat tcaagccata  38821 taa

[0202] In some embodiments of any of the vectors described herein, the vector includes a sequence encoding an antibody or antigen-binding antibody fragment that can bind specifically to VEGF. In some embodiments, an antibody or antigen-binding antibody fragment can include a human IgG Fc domain (e.g., SEQ ID NO: 113). In some embodiments, the sequence encoding an antibody or antigen-binding fragment can further include a sequence encoding a secretion signal sequence (e.g., SEQ ID NO: 92). In some embodiments of any of the vectors described herein, the vector comprises a sequence of a T2A peptidase (e.g., SEQ ID NO: 99).

[0203] In some embodiments, the antibody can be a humanized antibody, a chimeric antibody, or a multivalent antibody. In some embodiments, an antibody or an antigen-binding antibody fragment can be a scFv-Fc, a V.sub.HH domain, a V.sub.NAR domain, a (scFv).sub.2, a minibody, or a BiTE. In some embodiments, an antibody or an antigen-binding antibody fragment can be a DVD-Ig, and a dual-affinity re-targeting antibody (DART), a triomab, kih IgG with a common LC, a crossmab, an ortho-Fab IgG, a 2-in-1-IgG, IgG-ScFv, scFv.sub.2-Fc, a bi-nanobody, tanden antibody, a DART-Fc, a scFv-HAS-scFv, DNL-Fab3, DAF (two-in-one or four-in-one), DutaMab, DT-IgG, knobs-in-holes common LC, knobs-in-holes assembly, charge pair antibody, Fab-arm exchange antibody, SEEDbody, Triomab, LUZ-Y, Fcab, kλ-body, orthogonal Fab, DVD-IgG, IgG(H)-scFv, scFv-(H)IgG, IgG(L)-scFv, scFv-(L)-IgG, IgG (L,H)-Fc, IgG(H)-V, V(H)-IgG, IgG(L)-V, V(L)-IgG, KIH IgG-scFab, 2scFv-IgG, IgG-2scFv, scFv4-Ig, Zybody, DVI-IgG, nanobody, nanobody-HSA, a diabody, a TandAb, scDiabody, scDiabody-CH3, Diabody-CH3, Triple Body, miniantibody, minibody, TriBi minibody, scFv-CH3 MIL Fab-scFv, scFv-CH-CL-scFv, F(ab′).sub.2-scFV.sub.2, scFv-KIH, Fab-scFv-Fc, tetravalent HCAb, scDiabody-Fc, diabody-Fc, tandem scFv-Fc, intrabody, dock and lock bispecific antibody, ImmTAC, HSAbody, scDiabody-HAS, tandem scFv, IgG-IgG, Cov-X-Body, and scFv1-PEG-scFv2.

[0204] Additional examples of an antibody or an antigen-binding antibody fragment include an Fv fragment, a Fab fragment, a F(ab′)2 fragment, and a Fab′ fragment. Additional examples of an antibody or an antigen-binding antibody fragment include an antigen-binding fragment of an IgG (e.g., an antigen-binding fragment of IgG1, IgG2, IgG3, or IgG4) (e.g., an antigen-binding fragment of a human or humanized IgG, e.g., human or humanized IgG1, IgG2, IgG3, or IgG4); an antigen-binding fragment of an IgA (e.g., an antigen-binding fragment of IgA1 or IgA2) (e.g., an antigen-binding fragment of a human or humanized IgA, e.g., a human or humanized IgA1 or IgA2); an antigen-binding fragment of an IgD (e.g., an antigen-binding fragment of a human or humanized IgD); an antigen-binding fragment of an IgE (e.g., an antigen-binding fragment of a human or humanized IgE); or an antigen-binding fragment of an IgM (e.g., an antigen-binding fragment of a human or humanized IgM).

[0205] Any of the antibodies or antigen-binding antibody fragments described herein can bind specifically to VEGF.

[0206] A V.sub.HH domain is a single monomeric variable antibody domain that can be found in camelids. A V.sub.NAR domain is a single monomeric variable antibody domain that can be found in cartilaginous fish. Non-limiting aspects of V.sub.HH domains and V.sub.NAR domains are described in, e.g., Cromie et al., Curr. Top. Med. Chem. 15:2543-2557, 2016; De Genst et al., Dev. Comp. Immunol. 30:187-198, 2006; De Meyer et al., Trends Biotechnol. 32:263-270, 2014; Kijanka et al., Nanomedicine 10:161-174, 2015; Kovaleva et al., Expert. Opin. Biol. Ther 14:1527-1539, 2014; Krah et al., Immunopharmacol. Immunotoxicol. 38:21-28, 2016; Mujic-Delic et al., Trends Pharmacol. Sci. 35:247-255, 2014; Muyldermans, J. Biotechnol. 74:277-302, 2001; Muyldermans et al., Trends Biochem. Sci. 26:230-235, 2001; Muyldermans, Ann. Rev. Biochem. 82:775-797, 2013; Rahbarizadeh et al., Immunol. Invest. 40:299-338, 2011; Van Audenhove et al., EBioMedicine 8:40-48, 2016; Van Bockstaele et al., Curr. Opin. Investig. Drugs 10:1212-1224, 2009; Vincke et al., Methods Mol. Biol. 911:15-26, 2012; and Wesolowski et al., Med. Microbiol. Immunol. 198:157-174, 2009.

[0207] A “Fv” fragment includes a non-covalently-linked dimer of one heavy chain variable domain and one light chain variable domain.

[0208] A “Fab” fragment includes, the constant domain of the light chain and the first constant domain (C.sub.H1) of the heavy chain, in addition to the heavy and light chain variable domains of the Fv fragment.

[0209] A “F(ab′).sub.2” fragment includes two Fab fragments joined, near the hinge region, by disulfide bonds.

[0210] A “dual variable domain immunoglobulin” or “DVD-Ig” refers to multivalent and multispecific binding proteins as described, e.g., in DiGiammarino et al., Methods Mol. Biol. 899:145-156, 2012; Jakob et al., MABs 5:358-363, 2013; and U.S. Pat. Nos. 7,612,181; 8,258,268; 8,586,714; 8,716,450; 8,722,855; 8,735,546; and 8,822,645, each of which is incorporated by reference in its entirety.

[0211] DARTs are described in, e.g., Garber, Nature Reviews Drug Discovery 13:799-801, 2014.

[0212] Additional aspects of antibodies and antigen-binding antibody fragments are known in the art.

[0213] In some embodiments, any of the antibodies or antigen-binding antibody fragments described herein has a dissociation constant (KO of less than 1×10.sup.−5 M (e.g., less than 0.5×10.sup.−5 M, less than 1×10.sup.−6 M, less than 0.5×10.sup.−6 M, less than 1×10.sup.−7 M, less than 0.5×10.sup.−7 M, less than 1×10.sup.−8 M, less than 0.5×10.sup.−8 M, less than 1×10.sup.−9 M, less than 0.5×10.sup.−9 M, less than 1×10.sup.−10 M, less than 0.5×10.sup.−10 M, less than 1×10.sup.−11 M, less than 0.5×10.sup.−11 M, or less than 1×10.sup.−12 M), e.g., as measured in phosphate buffered saline using surface plasmon resonance (SPR) for a VEGF protein (e.g., any of the VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D).

[0214] In some embodiments, any of the antibodies or antigen-binding antibody fragments described herein has a K.sub.D of about 1×10.sup.−12 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, about 1×10.sup.−8 M, about 0.5×10.sup.−8 M, about 1×10.sup.−9 M, about 0.5×10.sup.−9 M, about 1×10.sup.−10 M, about 0.5×10.sup.−10 M, about 1×10.sup.−11 M, or about 0.5×10.sup.−11 M (inclusive); about 0.5×10.sup.−11 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, about 1×10.sup.−8 M, about 0.5×10.sup.−8 M, about 1×10.sup.−9 M, about 0.5×10.sup.−9 M, about 1×10.sup.−10 M, about 0.5×10.sup.−10 M, or about 1×10.sup.−11 M (inclusive); about 1×10.sup.−11 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, about 1×10.sup.−8 M, about 0.5×10.sup.−8 M, about 1×10.sup.−9 M, about 0.5×10.sup.−9 M, about 1×10.sup.−10 M, or about 0.5×10.sup.−10 M (inclusive); about 0.5×10.sup.−10 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, about 1×10.sup.−8 M, about 0.5×10.sup.−8 M, about 1×10.sup.−9 M, about 0.5×10.sup.−9 M, or about 1×10.sup.−10 M (inclusive); about 1×10.sup.−10 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, about 1×10.sup.−8 M, about 0.5×10.sup.−8 M, about 1×10.sup.−9 M, or about 0.5×10.sup.−9 M (inclusive); about 0.5×10.sup.−9 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, about 1×10.sup.−8 M, about 0.5×10.sup.−8 M, or about 1×10.sup.−9 M (inclusive); about 1×10.sup.−9 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, about 1×10.sup.−8 M, or about 0.5×10.sup.−8 M (inclusive); about 0.5×10.sup.−8 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, about 0.5×10.sup.−7 M, or about 1×10.sup.−8 M (inclusive); about 1×10.sup.−8 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, about 1×10.sup.−7 M, or about 0.5×10.sup.−7 M (inclusive); about 0.5×10.sup.−7 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, about 0.5×10.sup.−6 M, or about 1×10.sup.−7 M (inclusive); about 1×10.sup.−7 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, about 1×10.sup.−6 M, or about 0.5×10.sup.−6 M (inclusive); about 0.5×10.sup.−6 M to about 1×10.sup.−5 M, about 0.5×10.sup.−5 M, or about 1×10.sup.−6 M (inclusive); about 1×10.sup.−6 M to about 1×10.sup.−5 M or about 0.5×10.sup.−5 M (inclusive); or about 0.5×10.sup.−5 M to about 1×10.sup.−5 M (inclusive), e.g., as measured in phosphate buffered saline using surface plasmon resonance (SPR), for a VEGF protein (e.g., any of the VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D).

[0215] A variety of different methods known in the art can be used to determine the K.sub.D values of any of the antibodies or antigen-binding antibody fragments described herein (e.g., an electrophoretic mobility shift assay, a filter binding assay, surface plasmon resonance, and a biomolecular binding kinetics assay, etc.).

[0216] In some embodiments of any of the antibodies and/or antigen-binding antibody fragments described herein, the half-life of the antibody and/or the antigen-binding antibody fragment in a subject (e.g., a human) is decreased about 0.5-fold to about 4-fold (e.g., about 0.5-fold to about 3.5-fold, about 0.5-fold to about 3-fold, about 0.5-fold to about 2.5-fold, about 0.5-fold to about 2-fold, about 0.5-fold to about 1.5-fold, about 0.5-fold to about 1-fold, about 1-fold to about 4-fold, about 1-fold to about 3.5-fold, about 1-fold to about 3-fold, about 1-fold to about 2.5-fold, about 1-fold to about 2-fold, about 1.5-fold to about 4-fold, about 1.5-fold to about 3.5-fold, about 1.5-fold to about 3-fold, about 1.5-fold to about 2.5-fold, about 1.5-fold to about 2-fold, about 2-fold to about 4-fold, about 2-fold to about 3.5-fold, about 2-fold to about 3-fold, about 2-fold to about 2.5-fold, about 2.5-fold to about 4-fold, about 2.5-fold to about 3.5-fold, about 2.5-fold to about 3-fold, about 3-fold to about 4-fold, about 3-fold to about 3.5-fold, or about 3.5-fold to about 4-fold) as compared to the half-life of a control antibody and/or a control antigen-binding antibody fragment (e.g., any of the control antibodies and control antigen-binding antibody fragments described herein) in a similar subject. See, e.g., Leabman et al., MAbs. 5(6): 896-903, 2013. In some embodiments, an antibody or antigen-binding antibody fragment described herein has one or more amino acid substitutions in the Fc region that decrease its half-life in a mammal, and a control antibody lacks at least one (e.g., lacks all) of these one or more amino acid substitutions in the Fc region.

[0217] In some examples of any of the antibodies and antigen-binding fragments thereof described herein, the antibody and antigen-binding fragment can bind to a VEGF antigen (e.g., any of the exemplary VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D) (e.g., any of the binding affinities described herein).

[0218] In some embodiments described herein, an antibody or antigen-binding antibody fragment can decrease an activity of a VEGF (e.g., one or more of any of the exemplary VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D). In some embodiments, an antibody or antigen-binding antibody fragment can block a VEGF (e.g., one or more of any of the exemplary VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D) from binding to one or more of its receptors (e.g., one or more VEGF receptors) See, e.g., WO 1998/045331, U.S. Pat. No. 9,079,953, US 2015/0147317, US 2016/0289314, Plotkin et al., Otology & Neurotology 33: 1046-1052 (2012); and Ferrara et al. (2005) Biochem Biophys Res Commun 333(2): 328-335. In some embodiments, an antibody or antigen-binding antibody can decrease downstream signaling (e.g., signaling downstream of a VEGF receptor, e.g., one or more of any of the exemplary VEGF receptors described herein, e.g., one or more of human VEGFR-1 (SEQ ID NO: 111), human VEGFR-2 (SEQ ID NO: 112), and human VEGFR-3). In some embodiments, a decrease in an activity of a VEGF can be detected indirectly, e.g., through an increase in hearing (e.g., a 1% to about 400% increase (or any of the subranges of this range described herein) in hearing) or a decrease (e.g., a 1% to 99%, a 1% to 95%, a 1% to 90%, a 1% to 85%, a 1% to 80%, a 1% to 75%, a 1% to 70%, a 1% to 65%, a 1% to 60%, a 1% to 55%, a 1% to 50%, a 1% to 45%, a 1% to 40%, a 1% to 35%, a 1% to 30%, a 1% to 25%, a 1% to 20%, a 1% to 15%, a 1% to 10%, a 1% to 5%, a 5% to 99%, a 5% to 95%, a 5% to 90%, a 5% to 85%, a 5% to 80%, a 5% to 75%, a 5% to 70%, a 5% to 65%, a 5% to 60%, a 5% to 55%, a 5% to 50%, a 5% to 45%, a 5% to 40%, a 5% to 35%, a 5% to 30%, a 5% to 25%, a 5% to 20%, a 5% to 15%, a 5% to 10%, a 10% to 99%, a 10% to 95%, a 10% to 90%, a 10% to 85%, a 10% to 80%, a 10% to 75%, a 10% to 70%, a 10% to 65%, a 10% to 60%, a 10% to 55%, a 10% to 50%, a 10% to 45%, a 10% to 40%, a 10% to 35%, a 10% to 30%, a 10% to 25%, a 10% to 20%, a 10% to 15%, a 15% to 99%, a 15% to 95%, a 15% to 90%, a 15% to 85%, a 15% to 80%, a 15% to 75%, a 15% to 70%, a 15% to 65%, a 15% to 60%, a 15% to 55%, a 15% to 50%, a 15% to 45%, a 15% to 40%, a 15% to 35%, a 15% to 30%, a 15% to 25%, a 15% to 20%, a 20% to 99%, a 20% to 95%, a 20% to 90%, a 20% to 85%, a 20% to 80%, a 20% to 75%, a 20% to 70%, a 20% to 65%, a 20% to 60%, a 20% to 55%, a 20% to 50%, a 20% to 45%, a 20% to 40%, a 20% to 35%, a 20% to 30%, a 20% to 25%, a 25% to 99%, a 25% to 95%, a 25% to 90%, a 25% to 85%, a 25% to 80%, a 25% to 75%, a 25% to 70%, a 25% to 65%, a 25% to 60%, a 25% to 55%, a 25% to 50%, a 25% to 45%, a 25% to 40%, a 25% to 35%, a 25% to 30%, a 30% to 99%, a 30% to 95%, a 30% to 90%, a 30% to 85%, a 30% to 80%, a 30% to 75%, a 30% to 70%, a 30% to 65%, a 30% to 60%, a 30% to 55%, a 30% to 50%, a 30% to 45%, a 30% to 40%, a 30% to 35%, a 35% to 99%, a 35% to 95%, a 35% to 90%, a 35% to 85%, a 35% to 80%, a 35% to 75%, a 35% to 70%, a 35% to 65%, a 35% to 60%, a 35% to 55%, a 35% to 50%, a 35% to 45%, a 35% to 40%, a 40% to 99%, a 40% to 95%, a 40% to 90%, a 40% to 85%, a 40% to 80%, a 40% to 75%, a 40% to 70%, a 40% to 65%, a 40% to 60%, a 40% to 55%, a 40% to 50%, a 40% to 45%, a 45% to 99%, a 45% to 95%, a 45% to 90%, a 45% to 85%, a 45% to 80%, a 45% to 75%, a 45% to 70%, a 45% to 65%, a 45% to 60%, a 45% to 55%, a 45% to 50%, a 50% to 99%, a 50% to 95%, a 50% to 90%, a 50% to 85%, a 50% to 80%, a 50% to 75%, a 50% to 70%, a 50% to 65%, a 50% to 60%, a 50% to 55%, a 55% to 99%, a 55% to 95%, a 55% to 90%, a 55% to 85%, a 55% to 80%, a 55% to 75%, a 55% to 70%, a 55% to 65%, a 55% to 60%, a 60% to 99%, a 60% to 95%, a 60% to 90%, a 60% to 85%, a 60% to 80%, a 60% to 75%, a 60% to 70%, a 60% to 65%, a 65% to 99%, a 65% to 95%, a 65% to 90%, a 65% to 85%, a 65% to 80%, a 65% to 75%, a 65% to 70%, a 70% to 99%, a 70% to 95%, a 70% to 90%, a 70% to 85%, a 70% to 80%, a 70% to 75%, a 75% to 99%, a 75% to 95%, a 75% to 90%, a 75% to 85%, a 75% to 80%, a 80% to 99%, a 80% to 95%, a 80% to 90%, a 80% to 85%, a 85% to 99%, a 85% to 95%, a 85% to 90%, a 90% to 99%, a 90% to 95%, or a 95% to 99% decrease) in the size or the severity of one or more symptoms of an acoustic neuroma, vestibular schwannoma, or neurofibromatosis type II in a mammal as compared to the level of hearing or size of an acoustic neuroma, vestibular schwannoma, or neurofibromatosis type II in the mammal, respectively, before administration of any of the AAV vectors described herein. In some embodiments, a decrease in a VEGF activity can be detected in an in vitro assay.

[0219] In some embodiments, the antibody that specifically binds to a VEGF is bevacizumab (Avastatin®) (SEQ ID NO: 103) or an antigen-binding fragment thereof. Bevacizumab (full size antibody ˜150 kDa) inhibits all isoforms of VEGF-A. Bevacizumab received Food and Drug administration (FDA) approval in 2004 for colon cancer for intravenous (IV) dose of 4.0-7.5 mg/kg at 2-3 weeks (plasmatic half life 21 days), for intravetrial (IVT) dose 1.25 mg in 0.05 mL (half-life 5.6 days). Bevacizumab has a K.sub.D for VEGF 165 (VEGF-A) of 58 pM. See, e.g., WO 2017/050825. The leader sequence of bevacizumab is SEQ ID NO: 104, the heavy chain variable domain of bevacizumab is SEQ ID NO: 105, the heavy chain constant region of bevacizumab is SEQ ID NO: 106, the light chain variable domain of devacizumab is SEQ ID NO: 107, and the light chain constant region of bevacizumab is SEQ ID NO: 108. An exemplary cDNA sequence encoding bevacizumab is SEQ ID NO: 109.

[0220] In some embodiments, the antibody that specifically binds to a VEGF is ranibizumab (Lucentis®) (SEQ ID NO: 95), or an antigen-binding fragment thereof. Ranibizumab (˜50 kDa) inhibits all isoforms of VEGF-A. Ranibizumab received FDA approval in 2006 for ocular use for intravenous (IV) dose of 4.0-7.5 mg/kg at 2-3 weeks (plasma half life of 0.5 days), for intravetrial (IVT) dose 0.5 mg in 0.05 mL (half-life of 3.2 days). Ranibizumab has a K.sub.D for VEGF 165 (VEGF-A) of 46 pM. See, e.g., WO 2014/178078. The leader sequence of ranibizumab has a sequence of SEQ ID NO: 96, the heavy chain variable domain of ranibizumab has a sequence of SEQ ID NO: 97, the heavy chain constant region of ranibizumab has a sequence of SEQ ID NO: 98, the light chain variable domain of ranibizumab has a sequence of SE QID NO: 100, the light chain contant region of ranibizumab has a sequence of SEQ ID NO: 101. An exemplary cDNA sequence encoding ranibizumab is SEQ ID NO: 102.

[0221] In some embodiments, the antibody that specifically binds to VEGF is sevacizumab (APX003/SIM-BD0801), or an antigen-binding fragment thereof.

[0222] In some embodiments, the antibody or antigen-binding fragment thereof that specifically binds to VEGF is aflibercept (SEQ ID NO: 110). An exemplary cDNA sequence encoding aflibercept is SEQ ID NO: 114.

[0223] In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable light chain domain of bevacizumab, and/or includes a variable heavy chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable heavy chain domain of bevacizumab.

[0224] In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the variable light chain domain of bevacizumab, and/or a variable heavy chain domain that is or includes the variable heavy chain domain of bevacizumab. In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the sequence of variable light chain domain of bevacizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions, and/or includes a variable heavy chain domain that is or includes the sequence of variable heavy chain of bevacizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions. In some embodiments the first antigen-binding domain includes the three CDRs in the light chain variable domain of bevacizumab, and/or the three CDRs in the heavy chain variable domain of bevacizumab.

[0225] In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable light chain domain of ranibizumab, and/or includes a variable heavy chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable heavy chain domain of ranibizumab.

[0226] In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the variable light chain domain of ranibizumab, and/or a variable heavy chain domain that is or includes the variable heavy chain domain of ranibizumab. In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the sequence of variable light chain domain of ranibizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions, and/or includes a variable heavy chain domain that is or includes the sequence of variable heavy chain of ranibizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions. In some embodiments the first antigen-binding domain includes the three CDRs in the light chain variable domain of ranibizumab, and/or the three CDRs in the heavy chain variable domain of ranibizumab.

Vectors

[0227] The compositions provided herein include at least two (e.g., two, three, four, five, or six) nucleic acid vectors, where: each of the at least two different vectors includes a coding sequence that encodes a different portion of a target protein (e.g., a supporting cell target protein or a hair cell target protein), each of the encoded portions being at least 30 amino acids (e.g., about 30 amino acids to about 800 amino acids, about 30 amino acids to about 750 amino acids, about 30 amino acids to about 700 amino acids, about 30 amino acids to about 650 amino acids, about 30 amino acids to about 600 amino acids, about 30 amino acids to about 550 amino acids, about 30 amino acids to about 500 amino acids, about 30 amino acids to about 450 amino acids, about 30 amino acids to about 400 amino acids, about 30 amino acids to about 350 amino acids, about 30 amino acids to about 300 amino acids, about 30 amino acids to about 250 amino acids, about 30 amino acids to about 200 amino acids, about 30 amino acids to about 150 amino acids, about 30 amino acids to about 100 amino acids, about 30 amino acids to about 50 amino acids, about 50 amino acids to about 800 amino acids, about 50 amino acids to about 750 amino acids, about 50 amino acids to about 700 amino acids, about 50 amino acids to about 650 amino acids, about 50 amino acids to about 600 amino acids, about 50 amino acids to about 550 amino acids, about 50 amino acids to about 500 amino acids, about 50 amino acids to about 450 amino acids, about 50 amino acids to about 400 amino acids, about 50 amino acids to about 350 amino acids, about 50 amino acids to about 300 amino acids, about 50 amino acids to about 250 amino acids, about 50 amino acids to about 200 amino acids, about 50 amino acids to about 150 amino acids, about 50 amino acids to about 100 amino acids, about 100 amino acids to about 1600 amino acids, about 100 amino acids to about 800 amino acids, about 100 amino acids to about 750 amino acids, about 100 amino acids to about 700 amino acids, about 100 amino acids to about 650 amino acids, about 100 amino acids to about 600 amino acids, about 100 amino acids to about 550 amino acids, about 100 amino acids to about 500 amino acids, about 100 amino acids to about 450 amino acids, about 100 amino acids to about 400 amino acids, about 100 amino acids to about 350 amino acids, about 100 amino acids to about 300 amino acids, about 100 amino acids to about 250 amino acids, about 100 amino acids to about 200 amino acids, about 100 amino acids to about 150 amino acids, about 150 amino acids to about 800 amino acids, about 150 amino acids to about 750 amino acids, about 150 amino acids to about 700 amino acids, about 150 amino acids to about 650 amino acids, about 150 amino acids to about 600 amino acids, about 150 amino acids to about 550 amino acids, about 150 amino acids to about 500 amino acids, about 150 amino acids to about 450 amino acids, about 150 amino acids to about 400 amino acids, about 150 amino acids to about 350 amino acids, about 150 amino acids to about 300 amino acids, about 150 amino acids to about 250 amino acids, about 150 amino acids to about 200 amino acids, about 200 amino acids to about 800 amino acids, about 200 amino acids to about 750 amino acids, about 200 amino acids to about 700 amino acids, about 200 amino acids to about 650 amino acids, about 200 amino acids to about 600 amino acids, about 200 amino acids to about 550 amino acids, about 200 amino acids to about 500 amino acids, about 200 amino acids to about 450 amino acids, about 200 amino acids to about 400 amino acids, about 200 amino acids to about 350 amino acids, about 200 amino acids to about 300 amino acids, about 200 amino acids to about 250 amino acids, about 250 amino acids to about 800 amino acids, about 250 amino acids to about 750 amino acids, about 250 amino acids to about 700 amino acids, about 250 amino acids to about 650 amino acids, about 250 amino acids to about 600 amino acids, about 250 amino acids to about 550 amino acids, about 250 amino acids to about 500 amino acids, about 250 amino acids to about 450 amino acids, about 250 amino acids to about 400 amino acids, about 250 amino acids to about 350 amino acids, about 250 amino acids to about 300 amino acids, about 300 amino acids to about 800 amino acids, about 300 amino acids to about 750 amino acids, about 300 amino acids to about 700 amino acids, about 300 amino acids to about 650 amino acids, about 300 amino acids to about 600 amino acids, about 300 amino acids to about 550 amino acids, about 300 amino acids to about 500 amino acids, about 300 amino acids to about 450 amino acids, about 300 amino acids to about 400 amino acids, about 300 amino acids to about 350 amino acids, about 350 amino acids to about 800 amino acids, about 350 amino acids to about 750 amino acids, about 350 amino acids to about 700 amino acids, about 350 amino acids to about 650 amino acids, about 350 amino acids to about 600 amino acids, about 350 amino acids to about 550 amino acids, about 350 amino acids to about 500 amino acids, about 350 amino acids to about 450 amino acids, about 350 amino acids to about 400 amino acids, about 400 amino acids to about 800 amino acids, about 400 amino acids to about 750 amino acids, about 400 amino acids to about 700 amino acids, about 400 amino acids to about 650 amino acids, about 400 amino acids to about 600 amino acids, about 400 amino acids to about 550 amino acids, about 400 amino acids to about 500 amino acids, about 400 amino acids to about 450 amino acids, about 450 amino acids to about 800 amino acids, about 450 amino acids to about 750 amino acids, about 450 amino acids to about 700 amino acids, about 450 amino acids to about 650 amino acids, about 450 amino acids to about 600 amino acids, about 450 amino acids to about 550 amino acids, about 450 amino acids to about 500 amino acids, about 500 amino acids to about 800 amino acids, about 500 amino acids to about 750 amino acids, about 500 amino acids to about 700 amino acids, about 500 amino acids to about 650 amino acids, about 500 amino acids to about 600 amino acids, about 500 amino acids to about 550 amino acids, about 550 amino acids to about 800 amino acids, about 550 amino acids to about 750 amino acids, about 550 amino acids to about 700 amino acids, about 550 amino acids to about 650 amino acids, about 550 amino acids to about 600 amino acids, about 600 amino acids to about 800 amino acids, about 600 amino acids to about 750 amino acids, about 600 amino acids to about 700 amino acids, about 600 amino acids to about 650 amino acids, about 650 amino acids to about 800 amino acids, about 650 amino acids to about 750 amino acids, about 650 amino acids to about 700 amino acids, about 700 amino acids to about 800 amino acids, about 700 amino acids to about 750 amino acids, or about 750 amino acids to about 800 amino acids), where the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein (e.g., a full-length wildtype supporting cell target protein)) or an active hair cell target protein (e.g., a full-length hair cell target protein (e.g., a full-length wildtype hair cell target protein)); and, when introduced into a primate cell, the at least two different vectors undergo homologous recombination with each other, where the recombined nucleic acid encodes an active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein) or an active hair cell target protein (e.g., a full-length hair cell target protein). In some embodiments, one of the nucleic acid vectors can include a coding sequence that encodes a portion of a target protein (e.g., a supporting cell target protein or a hair cell target protein), where the encoded portion is, e.g., about 30 amino acids to about 800 amino acids, about 30 amino acids to about 750 amino acids, about 30 amino acids to about 700 amino acids, about 30 amino acids to about 650 amino acids, about 30 amino acids to about 600 amino acids, about 30 amino acids to about 550 amino acids, about 30 amino acids to about 500 amino acids, about 30 amino acids to about 450 amino acids, about 30 amino acids to about 400 amino acids, about 30 amino acids to about 350 amino acids, about 30 amino acids to about 300 amino acids, about 30 amino acids to about 250 amino acids, about 30 amino acids to about 200 amino acids, about 30 amino acids to about 150 amino acids, about 30 amino acids to about 100 amino acids, about 30 amino acids to about 50 amino acids, about 50 amino acids to about 800 amino acids, about 50 amino acids to about 750 amino acids, about 50 amino acids to about 700 amino acids, about 50 amino acids to about 650 amino acids, about 50 amino acids to about 600 amino acids, about 50 amino acids to about 550 amino acids, about 50 amino acids to about 500 amino acids, about 50 amino acids to about 450 amino acids, about 50 amino acids to about 400 amino acids, about 50 amino acids to about 350 amino acids, about 50 amino acids to about 300 amino acids, about 50 amino acids to about 250 amino acids, about 50 amino acids to about 200 amino acids, about 50 amino acids to about 150 amino acids, about 50 amino acids to about 100 amino acids, about 100 amino acids to about 1600 amino acids, about 100 amino acids to about 800 amino acids, about 100 amino acids to about 750 amino acids, about 100 amino acids to about 700 amino acids, about 100 amino acids to about 650 amino acids, about 100 amino acids to about 600 amino acids, about 100 amino acids to about 550 amino acids, about 100 amino acids to about 500 amino acids, about 100 amino acids to about 450 amino acids, about 100 amino acids to about 400 amino acids, about 100 amino acids to about 350 amino acids, about 100 amino acids to about 300 amino acids, about 100 amino acids to about 250 amino acids, about 100 amino acids to about 200 amino acids, about 100 amino acids to about 150 amino acids, about 150 amino acids to about 800 amino acids, about 150 amino acids to about 750 amino acids, about 150 amino acids to about 700 amino acids, about 150 amino acids to about 650 amino acids, about 150 amino acids to about 600 amino acids, about 150 amino acids to about 550 amino acids, about 150 amino acids to about 500 amino acids, about 150 amino acids to about 450 amino acids, about 150 amino acids to about 400 amino acids, about 150 amino acids to about 350 amino acids, about 150 amino acids to about 300 amino acids, about 150 amino acids to about 250 amino acids, about 150 amino acids to about 200 amino acids, about 200 amino acids to about 800 amino acids, about 200 amino acids to about 750 amino acids, about 200 amino acids to about 700 amino acids, about 200 amino acids to about 650 amino acids, about 200 amino acids to about 600 amino acids, about 200 amino acids to about 550 amino acids, about 200 amino acids to about 500 amino acids, about 200 amino acids to about 450 amino acids, about 200 amino acids to about 400 amino acids, about 200 amino acids to about 350 amino acids, about 200 amino acids to about 300 amino acids, about 200 amino acids to about 250 amino acids, about 250 amino acids to about 800 amino acids, about 250 amino acids to about 750 amino acids, about 250 amino acids to about 700 amino acids, about 250 amino acids to about 650 amino acids, about 250 amino acids to about 600 amino acids, about 250 amino acids to about 550 amino acids, about 250 amino acids to about 500 amino acids, about 250 amino acids to about 450 amino acids, about 250 amino acids to about 400 amino acids, about 250 amino acids to about 350 amino acids, about 250 amino acids to about 300 amino acids, about 300 amino acids to about 800 amino acids, about 300 amino acids to about 750 amino acids, about 300 amino acids to about 700 amino acids, about 300 amino acids to about 650 amino acids, about 300 amino acids to about 600 amino acids, about 300 amino acids to about 550 amino acids, about 300 amino acids to about 500 amino acids, about 300 amino acids to about 450 amino acids, about 300 amino acids to about 400 amino acids, about 300 amino acids to about 350 amino acids, about 350 amino acids to about 800 amino acids, about 350 amino acids to about 750 amino acids, about 350 amino acids to about 700 amino acids, about 350 amino acids to about 650 amino acids, about 350 amino acids to about 600 amino acids, about 350 amino acids to about 550 amino acids, about 350 amino acids to about 500 amino acids, about 350 amino acids to about 450 amino acids, about 350 amino acids to about 400 amino acids, about 400 amino acids to about 800 amino acids, about 400 amino acids to about 750 amino acids, about 400 amino acids to about 700 amino acids, about 400 amino acids to about 650 amino acids, about 400 amino acids to about 600 amino acids, about 400 amino acids to about 550 amino acids, about 400 amino acids to about 500 amino acids, about 400 amino acids to about 450 amino acids, about 450 amino acids to about 800 amino acids, about 450 amino acids to about 750 amino acids, about 450 amino acids to about 700 amino acids, about 450 amino acids to about 650 amino acids, about 450 amino acids to about 600 amino acids, about 450 amino acids to about 550 amino acids, about 450 amino acids to about 500 amino acids, about 500 amino acids to about 800 amino acids, about 500 amino acids to about 750 amino acids, about 500 amino acids to about 700 amino acids, about 500 amino acids to about 650 amino acids, about 500 amino acids to about 600 amino acids, about 500 amino acids to about 550 amino acids, about 550 amino acids to about 800 amino acids, about 550 amino acids to about 750 amino acids, about 550 amino acids to about 700 amino acids, about 550 amino acids to about 650 amino acids, about 550 amino acids to about 600 amino acids, about 600 amino acids to about 800 amino acids, about 600 amino acids to about 750 amino acids, about 600 amino acids to about 700 amino acids, about 600 amino acids to about 650 amino acids, about 650 amino acids to about 800 amino acids, about 650 amino acids to about 750 amino acids, about 650 amino acids to about 700 amino acids, about 700 amino acids to about 800 amino acids, about 700 amino acids to about 750 amino acids, or about 750 amino acids to about 800 amino acids in length.

[0228] In some embodiments of these compositions, at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of target genomic DNA (e.g., supporting cell target genomic DNA or hair cell target genomic DNA), and lacks the intronic sequence that naturally occurs between the two neighboring exons.

[0229] In some embodiments, the amino acid sequence of none of the encoded portions overlaps even in part with the amino acid sequence of a different one of the encoded portions. In some embodiments, the amino acid sequence of one or more of the encoded portions partially overlaps with the amino acid sequence of a different one of the encoded portions. In some embodiments, the amino acid sequence of each of the encoded portions partially overlaps with the amino acid sequence of a different one of the encoded portions.

[0230] In some embodiments, the overlapping amino acid sequence is between about 30 amino acid residues to about 800 amino acids (e.g., or any of the subranges of this range described herein) in length.

[0231] In some examples, the vectors include two different vectors, each of which includes a different segment of an intron, where the intron includes the nucleotide sequence of an intron that is present in a target genomic DNA (e.g., a supporting cell target genomic DNA (e.g., SLC26A4 genomic DNA or a GJB2 genomic DNA) (e.g., any of the exemplary introns in SEQ ID NO: 3 described herein) or a hair cell target genomic DNA (e.g., an OTOF genomic DNA, a TRIOBP genomic DNA, a PJVK genomic DNA, a NDP genomic DNA, a CLRN1 genomic DNA, a TMC1 genomic DNA, a VEGF genomic DNA, a HSPA1A genomic DNA, or a STRC genomic DNA (e.g., any of the exemplary introns in SEQ ID NO: 19, SEQ ID NO: 22, SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 50, SEQ ID NO: 61, SEQ ID NO: 71 or SEQ ID NO: 80 described herein), and where the two different segments overlap in sequence by at least 100 nucleotides (e.g., about 100 nucleotides to about 3,000 nucleotides, about 100 nucleotides to about 2,500 nucleotides, about 100 nucleotides to about 2,000 nucleotides, about 100 nucleotides to about 1,500 nucleotides, about 100 nucleotides to about 1,000 nucleotides, about 100 nucleotides to about 800 nucleotides, about 100 nucleotides to about 600 nucleotides, about 100 nucleotides to about 400 nucleotides, about 100 nucleotides to about 200 nucleotides, about 200 nucleotides to about 3,000 nucleotides, about 200 nucleotides to about 2,500 nucleotides, about 200 nucleotides to about 2,000 nucleotides, about 200 nucleotides to about 1,500 nucleotides, about 200 nucleotides to about 1,000 nucleotides, about 200 nucleotides to about 800 nucleotides, about 200 nucleotides to about 600 nucleotides, about 200 nucleotides to about 400 nucleotides, about 400 nucleotides to about 3,000 nucleotides, about 400 nucleotides to about 2,500 nucleotides, about 400 nucleotides to about 2,000 nucleotides, about 400 nucleotides to about 1,500 nucleotides, about 400 nucleotides to about 1,000 nucleotides, about 400 nucleotides to about 800 nucleotides, about 400 nucleotides to about 600 nucleotides, about 600 nucleotides to about 3,000 nucleotides, about 600 nucleotides to about 2,500 nucleotides, about 600 nucleotides to about 2,000 nucleotides, about 600 nucleotides to about 1,500 nucleotides, about 600 nucleotides to about 1,000 nucleotides, about 600 nucleotides to about 800 nucleotides, about 800 nucleotides to about 3,000 nucleotides, about 800 nucleotides to about 2,500 nucleotides, about 800 nucleotides to about 2,000 nucleotides, about 800 nucleotides to about 1,500 nucleotides, about 800 nucleotides to about 1,000 nucleotides, about 1,000 nucleotides to about 3,000 nucleotides, about 1,000 nucleotides to about 2,500 nucleotides, about 1,000 nucleotides to about 2,000 nucleotides, about 1,000 nucleotides to about 1,500 nucleotides, about 1,500 nucleotides to about 3,000 nucleotides, about 1,500 nucleotides to about 2,500 nucleotides, about 1,500 nucleotides to about 2,000 nucleotides, about 2,000 nucleotides to about 3,000 nucleotides, about 2,000 nucleotides to about 2,500 nucleotides, or about 2,500 nucleotides to about 3,000 nucleotides), in length.

[0232] The overlapping nucleotide sequence in any two of the different vectors can include part or all of one or more exons of a target gene (e.g., a supporting cell target gene (e.g., a SLC26A4 gene or a GJB2 gene) (e.g., any one or more of the exemplary exons in SEQ ID NO: 3 described herein) or a hair cell target gene (e.g., an OTOF gene, a TRIOBP gene, a PJVK gene, a NDP gene, a CLRN1 gene, a TMC1 gene, or a STRC gene) (e.g., any one or more of the exemplary exons in SEQ ID NO: 19, SEQ ID NO: 22, SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 50, SEQ ID NO: 63, SEQ ID NO: 71 or SEQ ID NO: 80 described herein).

[0233] In some embodiments, the number of different vectors in the composition is two, three, four, or five. In compositions where the number of different vectors in the composition is two, the first of the two different vectors can include a coding sequence that encodes an N-terminal portion of the target protein (e.g., an N-terminal portion of the supporting cell target protein or an N-terminal portion of the hair cell target protein). In some examples, the N-terminal portion of the target gene (e.g., the N-terminal portion of the supporting cell target gene or the N-terminal portion of the hair cell target gene) is between about 30 amino acids to about 800 amino acids (e.g., between about 30 amino acids to about 790 amino acids, between about 30 amino acids to about 780 amino acids, between about 30 amino acids to about 770 amino acids, between about 30 amino acids to about 760 amino acids, between about 30 amino acids to about 750 amino acids, between about 30 amino acids to about 740 amino acids, between about 30 amino acids to about 730 amino acids, between about 30 amino acids to about 720 amino acids, between about 30 amino acids to about 710 amino acids, between about 30 amino acids to about 700 amino acids, between about 30 amino acids to about 690 amino acids, between about 30 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 30 amino acids to about 660 amino acids, between about 30 amino acids to about 650 amino acids, between about 30 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 30 amino acids to about 620 amino acids, between about 30 amino acids to about 610 amino acids, between about 30 amino acids to about 600 amino acids, between about 30 amino acids to about 590 amino acids, between about 30 amino acids to about 580 amino acids, between about 30 amino acids to about 570 amino acids, between about 30 amino acids to about 560 amino acids, between about 30 amino acids to about 550 amino acids, between about 30 amino acids to about 540 amino acids, between about 30 amino acids to about 530 amino acids, between about 30 amino acids to about 520 amino acids, between about 30 amino acids to about 510 amino acids, between about 30 amino acids to about 500 amino acids, between about 30 amino acids to about 490 amino acids, between about 30 amino acids to about 480 amino acids, between about 30 amino acids to about 470 amino acids, between about 30 amino acids to about 460 amino acids, between about 30 amino acids to about 450 amino acids, between about 30 amino acids to about 440 amino acids, between about 30 amino acids to about 430 amino acids, between about 30 amino acids to about 420 amino acids, between about 30 amino acids to about 410 amino acids, between about 30 amino acids to about 400 amino acids, between about 30 amino acids to about 390 amino acids, between about 30 amino acids to about 380 amino acids, between about 30 amino acids to about 370 amino acids, between about 30 amino acids to about 360 amino acids, between about 30 amino acids to about 350 amino acids, between about 30 amino acids to about 340 amino acids, between about 30 amino acids to about 330 amino acids, between about 30 amino acids to about 320 amino acids, between about 30 amino acids to about 310 amino acids, between about 30 amino acids to about 300 amino acids, between about 30 amino acids to about 290 amino acids, between about 30 amino acids to about 280 amino acids, between about 30 amino acids to about 270 amino acids, between about 30 amino acids to about 260 amino acids, between about 30 amino acids to about 250 amino acids, between about 30 amino acids to about 240 amino acids, between about 30 amino acids to about 230 amino acids, between about 30 amino acids to about 220 amino acids, between about 30 amino acids to about 210 amino acids, between about 30 amino acids to about 200 amino acids, between about 30 amino acids to about 190 amino acids, between about 30 amino acids to about 180 amino acids, between about 30 amino acids to about 170 amino acids, between about 30 amino acids to about 160 amino acids, between about 30 amino acids to about 150 amino acids, between about 30 amino acids to about 140 amino acids, between about 30 amino acids to about 130 amino acids, between about 30 amino acids to about 120 amino acids, between about 30 amino acids to about 110 amino acids, between about 30 amino acids to about 100 amino acids, between about 30 amino acids to about 90 amino acids, between about 30 amino acids to about 80 amino acids, between about 30 amino acids to about 70 amino acids, between about 30 amino acids to about 60 amino acids, between about 30 amino acids to about 50 amino acids, between about 30 amino acids to about 40 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 50 amino acids to about 500 amino acids, between about 50 amino acids to about 490 amino acids, between about 50 amino acids to about 480 amino acids, between about 50 amino acids to about 470 amino acids, between about 50 amino acids to about 460 amino acids, between about 50 amino acids to about 450 amino acids, between about 50 amino acids to about 440 amino acids, between about 50 amino acids to about 430 amino acids, between about 50 amino acids to about 420 amino acids, between about 50 amino acids to about 410 amino acids, between about 50 amino acids to about 400 amino acids, between about 50 amino acids to about 390 amino acids, between about 50 amino acids to about 380 amino acids, between about 50 amino acids to about 370 amino acids, between about 50 amino acids to about 360 amino acids, between about 50 amino acids to about 350 amino acids, between about 50 amino acids to about 340 amino acids, between about 50 amino acids to about 330 amino acids, between about 50 amino acids to about 320 amino acids, between about 50 amino acids to about 310 amino acids, between about 50 amino acids to about 300 amino acids, between about 50 amino acids to about 290 amino acids, between about 50 amino acids to about 280 amino acids, between about 50 amino acids to about 270 amino acids, between about 50 amino acids to about 260 amino acids, between about 50 amino acids to about 250 amino acids, between about 50 amino acids to about 240 amino acids, between about 50 amino acids to about 230 amino acids, between about 50 amino acids to about 220 amino acids, between about 50 amino acids to about 210 amino acids, between about 50 amino acids to about 200 amino acids, between about 50 amino acids to about 190 amino acids, between about 50 amino acids to about 180 amino acids, between about 50 amino acids to about 170 amino acids, between about 50 amino acids to about 160 amino acids, between about 50 amino acids to about 150 amino acids, between about 50 amino acids to about 140 amino acids, between about 50 amino acids to about 130 amino acids, between about 50 amino acids to about 120 amino acids, between about 50 amino acids to about 110 amino acids, between about 50 amino acids to about 100 amino acids, between about 50 amino acids to about 90 amino acids, between about 50 amino acids to about 80 amino acids, between about 50 amino acids to about 70 amino acids, between about 50 amino acids to about 60 amino acids, between about 80 amino acids to about 800 amino acids, between about 80 amino acids to about 790 amino acids, between about 80 amino acids to about 780 amino acids, between about 80 amino acids to about 770 amino acids, between about 80 amino acids to about 760 amino acids, between about 80 amino acids to about 750 amino acids, between about 80 amino acids to about 740 amino acids, between about 80 amino acids to about 730 amino acids, between about 80 amino acids to about 720 amino acids, between about 80 amino acids to about 710 amino acids, between about 80 amino acids to about 700 amino acids, between about 80 amino acids to about 690 amino acids, between about 80 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 80 amino acids to about 660 amino acids, between about 80 amino acids to about 650 amino acids, between about 80 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 80 amino acids to about 620 amino acids, between about 80 amino acids to about 610 amino acids, between about 80 amino acids to about 600 amino acids, between about 80 amino acids to about 590 amino acids, between about 80 amino acids to about 580 amino acids, between about 80 amino acids to about 570 amino acids, between about 80 amino acids to about 560 amino acids, between about 80 amino acids to about 550 amino acids, between about 80 amino acids to about 540 amino acids, between about 80 amino acids to about 530 amino acids, between about 80 amino acids to about 520 amino acids, between about 80 amino acids to about 510 amino acids, between about 80 amino acids to about 500 amino acids, between about 80 amino acids to about 490 amino acids, between about 80 amino acids to about 480 amino acids, between about 80 amino acids to about 470 amino acids, between about 80 amino acids to about 460 amino acids, between about 80 amino acids to about 450 amino acids, between about 80 amino acids to about 440 amino acids, between about 80 amino acids to about 430 amino acids, between about 80 amino acids to about 420 amino acids, between about 80 amino acids to about 410 amino acids, between about 80 amino acids to about 400 amino acids, between about 80 amino acids to about 390 amino acids, between about 80 amino acids to about 380 amino acids, between about 80 amino acids to about 370 amino acids, between about 80 amino acids to about 360 amino acids, between about 80 amino acids to about 350 amino acids, between about 80 amino acids to about 340 amino acids, between about 80 amino acids to about 330 amino acids, between about 80 amino acids to about 320 amino acids, between about 80 amino acids to about 310 amino acids, between about 80 amino acids to about 300 amino acids, between about 80 amino acids to about 290 amino acids, between about 80 amino acids to about 280 amino acids, between about 80 amino acids to about 270 amino acids, between about 80 amino acids to about 260 amino acids, between about 80 amino acids to about 250 amino acids, between about 80 amino acids to about 240 amino acids, between about 80 amino acids to about 230 amino acids, between about 80 amino acids to about 220 amino acids, between about 80 amino acids to about 210 amino acids, between about 80 amino acids to about 200 amino acids, between about 80 amino acids to about 190 amino acids, between about 80 amino acids to about 180 amino acids, between about 80 amino acids to about 170 amino acids, between about 80 amino acids to about 160 amino acids, between about 80 amino acids to about 150 amino acids, between about 80 amino acids to about 140 amino acids, between about 80 amino acids to about 130 amino acids, between about 80 amino acids to about 120 amino acids, between about 80 amino acids to about 110 amino acids, between about 80 amino acids to about 100 amino acids, between about 100 amino acids to about 800 amino acids, between about 100 amino acids to about 790 amino acids, between about 100 amino acids to about 780 amino acids, between about 100 amino acids to about 770 amino acids, between about 100 amino acids to about 760 amino acids, between about 100 amino acids to about 750 amino acids, between about 100 amino acids to about 740 amino acids, between about 100 amino acids to about 730 amino acids, between about 100 amino acids to about 720 amino acids, between about 100 amino acids to about 710 amino acids, between about 100 amino acids to about 700 amino acids, between about 100 amino acids to about 690 amino acids, between about 100 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 100 amino acids to about 660 amino acids, between about 100 amino acids to about 650 amino acids, between about 100 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 100 amino acids to about 620 amino acids, between about 100 amino acids to about 610 amino acids, between about 100 amino acids to about 600 amino acids, between about 100 amino acids to about 590 amino acids, between about 100 amino acids to about 580 amino acids, between about 100 amino acids to about 570 amino acids, between about 100 amino acids to about 560 amino acids, between about 100 amino acids to about 550 amino acids, between about 100 amino acids to about 540 amino acids, between about 100 amino acids to about 530 amino acids, between about 100 amino acids to about 520 amino acids, between about 100 amino acids to about 510 amino acids, between about 100 amino acids to about 500 amino acids, between about 100 amino acids to about 490 amino acids, between about 100 amino acids to about 480 amino acids, between about 100 amino acids to about 470 amino acids, between about 100 amino acids to about 460 amino acids, between about 100 amino acids to about 450 amino acids, between about 100 amino acids to about 440 amino acids, between about 100 amino acids to about 430 amino acids, between about 100 amino acids to about 420 amino acids, between about 100 amino acids to about 410 amino acids, between about 100 amino acids to about 400 amino acids, between about 100 amino acids to about 390 amino acids, between about 100 amino acids to about 380 amino acids, between about 100 amino acids to about 370 amino acids, between about 100 amino acids to about 360 amino acids, between about 100 amino acids to about 350 amino acids, between about 100 amino acids to about 340 amino acids, between about 100 amino acids to about 330 amino acids, between about 100 amino acids to about 320 amino acids, between about 100 amino acids to about 310 amino acids, between about 100 amino acids to about 300 amino acids, between about 100 amino acids to about 290 amino acids, between about 100 amino acids to about 280 amino acids, between about 100 amino acids to about 270 amino acids, between about 100 amino acids to about 260 amino acids, between about 100 amino acids to about 250 amino acids, between about 100 amino acids to about 240 amino acids, between about 100 amino acids to about 230 amino acids, between about 100 amino acids to about 220 amino acids, between about 100 amino acids to about 210 amino acids, between about 100 amino acids to about 200 amino acids, between about 100 amino acids to about 190 amino acids, between about 100 amino acids to about 180 amino acids, between about 100 amino acids to about 170 amino acids, between about 100 amino acids to about 160 amino acids, between about 100 amino acids to about 150 amino acids, between about 100 amino acids to about 140 amino acids, between about 100 amino acids to about 130 amino acids, between about 100 amino acids to about 120 amino acids, between about 100 amino acids to about 110 amino acids, between about 120 amino acids to about 800 amino acids, between about 120 amino acids to about 790 amino acids, between about 120 amino acids to about 780 amino acids, between about 120 amino acids to about 770 amino acids, between about 120 amino acids to about 760 amino acids, between about 120 amino acids to about 750 amino acids, between about 120 amino acids to about 740 amino acids, between about 120 amino acids to about 730 amino acids, between about 120 amino acids to about 720 amino acids, between about 120 amino acids to about 710 amino acids, between about 120 amino acids to about 700 amino acids, between about 120 amino acids to about 690 amino acids, between about 120 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 120 amino acids to about 660 amino acids, between about 120 amino acids to about 650 amino acids, between about 120 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 120 amino acids to about 620 amino acids, between about 120 amino acids to about 610 amino acids, between about 120 amino acids to about 600 amino acids, between about 120 amino acids to about 590 amino acids, between about 120 amino acids to about 580 amino acids, between about 120 amino acids to about 570 amino acids, between about 120 amino acids to about 560 amino acids, between about 120 amino acids to about 550 amino acids, between about 120 amino acids to about 540 amino acids, between about 120 amino acids to about 530 amino acids, between about 120 amino acids to about 520 amino acids, between about 120 amino acids to about 510 amino acids, between about 120 amino acids to about 500 amino acids, between about 120 amino acids to about 490 amino acids, between about 120 amino acids to about 480 amino acids, between about 120 amino acids to about 470 amino acids, between about 120 amino acids to about 460 amino acids, between about 120 amino acids to about 450 amino acids, between about 120 amino acids to about 440 amino acids, between about 120 amino acids to about 430 amino acids, between about 120 amino acids to about 420 amino acids, between about 120 amino acids to about 410 amino acids, between about 120 amino acids to about 400 amino acids, between about 120 amino acids to about 390 amino acids, between about 120 amino acids to about 380 amino acids, between about 120 amino acids to about 370 amino acids, between about 120 amino acids to about 360 amino acids, between about 120 amino acids to about 350 amino acids, between about 120 amino acids to about 340 amino acids, between about 120 amino acids to about 330 amino acids, between about 120 amino acids to about 320 amino acids, between about 120 amino acids to about 310 amino acids, between about 120 amino acids to about 300 amino acids, between about 120 amino acids to about 290 amino acids, between about 120 amino acids to about 280 amino acids, between about 120 amino acids to about 270 amino acids, between about 120 amino acids to about 260 amino acids, between about 120 amino acids to about 250 amino acids, between about 120 amino acids to about 240 amino acids, between about 120 amino acids to about 230 amino acids, between about 120 amino acids to about 220 amino acids, between about 120 amino acids to about 210 amino acids, between about 120 amino acids to about 200 amino acids, between about 120 amino acids to about 190 amino acids, between about 120 amino acids to about 180 amino acids, between about 120 amino acids to about 170 amino acids, between about 120 amino acids to about 160 amino acids, between about 120 amino acids to about 150 amino acids, between about 120 amino acids to about 140 amino acids, between about 120 amino acids to about 130 amino acids, between about 150 amino acids to about 800 amino acids, between about 150 amino acids to about 790 amino acids, between about 150 amino acids to about 780 amino acids, between about 150 amino acids to about 770 amino acids, between about 150 amino acids to about 760 amino acids, between about 150 amino acids to about 750 amino acids, between about 150 amino acids to about 740 amino acids, between about 150 amino acids to about 730 amino acids, between about 150 amino acids to about 720 amino acids, between about 150 amino acids to about 710 amino acids, between about 150 amino acids to about 700 amino acids, between about 150 amino acids to about 690 amino acids, between about 150 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 150 amino acids to about 660 amino acids, between about 150 amino acids to about 650 amino acids, between about 150 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 150 amino acids to about 620 amino acids, between about 150 amino acids to about 610 amino acids, between about 150 amino acids to about 600 amino acids, between about 150 amino acids to about 590 amino acids, between about 150 amino acids to about 580 amino acids, between about 150 amino acids to about 570 amino acids, between about 150 amino acids to about 560 amino acids, between about 150 amino acids to about 550 amino acids, between about 150 amino acids to about 540 amino acids, between about 150 amino acids to about 530 amino acids, between about 150 amino acids to about 520 amino acids, between about 150 amino acids to about 510 amino acids, between about 150 amino acids to about 500 amino acids, between about 150 amino acids to about 490 amino acids, between about 150 amino acids to about 480 amino acids, between about 150 amino acids to about 470 amino acids, between about 150 amino acids to about 460 amino acids, between about 150 amino acids to about 450 amino acids, between about 150 amino acids to about 440 amino acids, between about 150 amino acids to about 430 amino acids, between about 150 amino acids to about 420 amino acids, between about 150 amino acids to about 410 amino acids, between about 150 amino acids to about 400 amino acids, between about 150 amino acids to about 390 amino acids, between about 150 amino acids to about 380 amino acids, between about 150 amino acids to about 370 amino acids, between about 150 amino acids to about 360 amino acids, between about 150 amino acids to about 350 amino acids, between about 150 amino acids to about 340 amino acids, between about 150 amino acids to about 330 amino acids, between about 150 amino acids to about 320 amino acids, between about 150 amino acids to about 310 amino acids, between about 150 amino acids to about 300 amino acids, between about 150 amino acids to about 290 amino acids, between about 150 amino acids to about 280 amino acids, between about 150 amino acids to about 270 amino acids, between about 150 amino acids to about 260 amino acids, between about 150 amino acids to about 250 amino acids, between about 150 amino acids to about 240 amino acids, between about 150 amino acids to about 230 amino acids, between about 150 amino acids to about 220 amino acids, between about 150 amino acids to about 210 amino acids, between about 150 amino acids to about 200 amino acids, between about 150 amino acids to about 190 amino acids, between about 150 amino acids to about 180 amino acids, between about 150 amino acids to about 170 amino acids, between about 150 amino acids to about 160 amino acids, between about 180 amino acids to about 800 amino acids, between about 180 amino acids to about 790 amino acids, between about 180 amino acids to about 780 amino acids, between about 180 amino acids to about 770 amino acids, between about 180 amino acids to about 760 amino acids, between about 180 amino acids to about 750 amino acids, between about 180 amino acids to about 740 amino acids, between about 180 amino acids to about 730 amino acids, between about 180 amino acids to about 720 amino acids, between about 180 amino acids to about 710 amino acids, between about 180 amino acids to about 700 amino acids, between about 180 amino acids to about 690 amino acids, between about 180 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 180 amino acids to about 660 amino acids, between about 180 amino acids to about 650 amino acids, between about 180 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 180 amino acids to about 620 amino acids, between about 180 amino acids to about 610 amino acids, between about 180 amino acids to about 600 amino acids, between about 180 amino acids to about 590 amino acids, between about 180 amino acids to about 580 amino acids, between about 180 amino acids to about 570 amino acids, between about 180 amino acids to about 560 amino acids, between about 180 amino acids to about 550 amino acids, between about 180 amino acids to about 540 amino acids, between about 180 amino acids to about 530 amino acids, between about 180 amino acids to about 520 amino acids, between about 180 amino acids to about 510 amino acids, between about 180 amino acids to about 500 amino acids, between about 180 amino acids to about 490 amino acids, between about 180 amino acids to about 480 amino acids, between about 180 amino acids to about 470 amino acids, between about 180 amino acids to about 460 amino acids, between about 180 amino acids to about 450 amino acids, between about 180 amino acids to about 440 amino acids, between about 180 amino acids to about 430 amino acids, between about 180 amino acids to about 420 amino acids, between about 180 amino acids to about 410 amino acids, between about 180 amino acids to about 400 amino acids, between about 180 amino acids to about 390 amino acids, between about 180 amino acids to about 380 amino acids, between about 180 amino acids to about 370 amino acids, between about 180 amino acids to about 360 amino acids, between about 180 amino acids to about 350 amino acids, between about 180 amino acids to about 340 amino acids, between about 180 amino acids to about 330 amino acids, between about 180 amino acids to about 320 amino acids, between about 180 amino acids to about 310 amino acids, between about 180 amino acids to about 300 amino acids, between about 180 amino acids to about 290 amino acids, between about 180 amino acids to about 280 amino acids, between about 180 amino acids to about 270 amino acids, between about 180 amino acids to about 260 amino acids, between about 180 amino acids to about 250 amino acids, between about 180 amino acids to about 240 amino acids, between about 180 amino acids to about 230 amino acids, between about 180 amino acids to about 220 amino acids, between about 180 amino acids to about 210 amino acids, between about 180 amino acids to about 200 amino acids, between about 180 amino acids to about 190 amino acids, between about 200 amino acids to about 800 amino acids, between about 200 amino acids to about 790 amino acids, between about 200 amino acids to about 780 amino acids, between about 200 amino acids to about 770 amino acids, between about 200 amino acids to about 760 amino acids, between about 200 amino acids to about 750 amino acids, between about 200 amino acids to about 740 amino acids, between about 200 amino acids to about 730 amino acids, between about 200 amino acids to about 720 amino acids, between about 200 amino acids to about 710 amino acids, between about 200 amino acids to about 700 amino acids, between about 200 amino acids to about 690 amino acids, between about 200 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 200 amino acids to about 660 amino acids, between about 200 amino acids to about 650 amino acids, between about 200 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 200 amino acids to about 620 amino acids, between about 200 amino acids to about 610 amino acids, between about 200 amino acids to about 600 amino acids, between about 200 amino acids to about 590 amino acids, between about 200 amino acids to about 580 amino acids, between about 200 amino acids to about 570 amino acids, between about 200 amino acids to about 560 amino acids, between about 200 amino acids to about 550 amino acids, between about 200 amino acids to about 540 amino acids, between about 200 amino acids to about 530 amino acids, between about 200 amino acids to about 520 amino acids, between about 200 amino acids to about 510 amino acids, between about 200 amino acids to about 500 amino acids, between about 200 amino acids to about 490 amino acids, between about 200 amino acids to about 480 amino acids, between about 200 amino acids to about 470 amino acids, between about 200 amino acids to about 460 amino acids, between about 200 amino acids to about 450 amino acids, between about 200 amino acids to about 440 amino acids, between about 200 amino acids to about 430 amino acids, between about 200 amino acids to about 420 amino acids, between about 200 amino acids to about 410 amino acids, between about 200 amino acids to about 400 amino acids, between about 200 amino acids to about 390 amino acids, between about 200 amino acids to about 380 amino acids, between about 200 amino acids to about 370 amino acids, between about 200 amino acids to about 360 amino acids, between about 200 amino acids to about 350 amino acids, between about 200 amino acids to about 340 amino acids, between about 200 amino acids to about 330 amino acids, between about 200 amino acids to about 320 amino acids, between about 200 amino acids to about 310 amino acids, between about 200 amino acids to about 300 amino acids, between about 200 amino acids to about 290 amino acids, between about 200 amino acids to about 280 amino acids, between about 200 amino acids to about 270 amino acids, between about 200 amino acids to about 260 amino acids, between about 200 amino acids to about 250 amino acids, between about 200 amino acids to about 240 amino acids, between about 200 amino acids to about 230 amino acids, between about 200 amino acids to about 220 amino acids, between about 200 amino acids to about 210 amino acids, between about 250 amino acids to about 800 amino acids, between about 250 amino acids to about 790 amino acids, between about 250 amino acids to about 780 amino acids, between about 250 amino acids to about 770 amino acids, between about 250 amino acids to about 760 amino acids, between about 250 amino acids to about 750 amino acids, between about 250 amino acids to about 740 amino acids, between about 250 amino acids to about 730 amino acids, between about 250 amino acids to about 720 amino acids, between about 250 amino acids to about 710 amino acids, between about 250 amino acids to about 700 amino acids, between about 250 amino acids to about 690 amino acids, between about 250 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 250 amino acids to about 660 amino acids, between about 250 amino acids to about 650 amino acids, between about 250 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 250 amino acids to about 620 amino acids, between about 250 amino acids to about 610 amino acids, between about 250 amino acids to about 600 amino acids, between about 250 amino acids to about 590 amino acids, between about 250 amino acids to about 580 amino acids, between about 250 amino acids to about 570 amino acids, between about 250 amino acids to about 560 amino acids, between about 250 amino acids to about 550 amino acids, between about 250 amino acids to about 540 amino acids, between about 250 amino acids to about 530 amino acids, between about 250 amino acids to about 520 amino acids, between about 250 amino acids to about 510 amino acids, between about 250 amino acids to about 500 amino acids, between about 250 amino acids to about 490 amino acids, between about 250 amino acids to about 480 amino acids, between about 250 amino acids to about 470 amino acids, between about 250 amino acids to about 460 amino acids, between about 250 amino acids to about 450 amino acids, between about 250 amino acids to about 440 amino acids, between about 250 amino acids to about 430 amino acids, between about 250 amino acids to about 420 amino acids, between about 250 amino acids to about 410 amino acids, between about 250 amino acids to about 400 amino acids, between about 250 amino acids to about 390 amino acids, between about 250 amino acids to about 380 amino acids, between about 250 amino acids to about 370 amino acids, between about 250 amino acids to about 360 amino acids, between about 250 amino acids to about 350 amino acids, between about 250 amino acids to about 340 amino acids, between about 250 amino acids to about 330 amino acids, between about 250 amino acids to about 320 amino acids, between about 250 amino acids to about 310 amino acids, between about 250 amino acids to about 300 amino acids, between about 250 amino acids to about 290 amino acids, between about 250 amino acids to about 280 amino acids, between about 250 amino acids to about 270 amino acids, between about 250 amino acids to about 260 amino acids, between about 280 amino acids to about 800 amino acids, between about 280 amino acids to about 790 amino acids, between about 280 amino acids to about 780 amino acids, between about 280 amino acids to about 770 amino acids, between about 280 amino acids to about 760 amino acids, between about 280 amino acids to about 750 amino acids, between about 280 amino acids to about 740 amino acids, between about 280 amino acids to about 730 amino acids, between about 280 amino acids to about 720 amino acids, between about 280 amino acids to about 710 amino acids, between about 280 amino acids to about 700 amino acids, between about 280 amino acids to about 690 amino acids, between about 280 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 280 amino acids to about 660 amino acids, between about 280 amino acids to about 650 amino acids, between about 280 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 280 amino acids to about 620 amino acids, between about 280 amino acids to about 610 amino acids, between about 280 amino acids to about 600 amino acids, between about 280 amino acids to about 590 amino acids, between about 280 amino acids to about 580 amino acids, between about 280 amino acids to about 570 amino acids, between about 280 amino acids to about 560 amino acids, between about 280 amino acids to about 550 amino acids, between about 280 amino acids to about 540 amino acids, between about 280 amino acids to about 530 amino acids, between about 280 amino acids to about 520 amino acids, between about 280 amino acids to about 510 amino acids, between about 280 amino acids to about 500 amino acids, between about 280 amino acids to about 490 amino acids, between about 280 amino acids to about 480 amino acids, between about 280 amino acids to about 470 amino acids, between about 280 amino acids to about 460 amino acids, between about 280 amino acids to about 450 amino acids, between about 280 amino acids to about 440 amino acids, between about 280 amino acids to about 430 amino acids, between about 280 amino acids to about 420 amino acids, between about 280 amino acids to about 410 amino acids, between about 280 amino acids to about 400 amino acids, between about 280 amino acids to about 390 amino acids, between about 280 amino acids to about 380 amino acids, between about 280 amino acids to about 370 amino acids, between about 280 amino acids to about 360 amino acids, between about 280 amino acids to about 350 amino acids, between about 280 amino acids to about 340 amino acids, between about 280 amino acids to about 330 amino acids, between about 280 amino acids to about 320 amino acids, between about 280 amino acids to about 310 amino acids, between about 280 amino acids to about 300 amino acids, between about 300 amino acids to about 800 amino acids, between about 300 amino acids to about 790 amino acids, between about 300 amino acids to about 780 amino acids, between about 300 amino acids to about 770 amino acids, between about 300 amino acids to about 760 amino acids, between about 300 amino acids to about 750 amino acids, between about 300 amino acids to about 740 amino acids, between about 300 amino acids to about 730 amino acids, between about 300 amino acids to about 720 amino acids, between about 300 amino acids to about 710 amino acids, between about 300 amino acids to about 700 amino acids, between about 300 amino acids to about 690 amino acids, between about 300 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 300 amino acids to about 660 amino acids, between about 300 amino acids to about 650 amino acids, between about 300 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 300 amino acids to about 620 amino acids, between about 300 amino acids to about 610 amino acids, between about 300 amino acids to about 600 amino acids, between about 300 amino acids to about 590 amino acids, between about 300 amino acids to about 580 amino acids, between about 300 amino acids to about 570 amino acids, between about 300 amino acids to about 560 amino acids, between about 300 amino acids to about 550 amino acids, between about 300 amino acids to about 540 amino acids, between about 300 amino acids to about 530 amino acids, between about 300 amino acids to about 520 amino acids, between about 300 amino acids to about 510 amino acids, between about 300 amino acids to about 500 amino acids, between about 300 amino acids to about 490 amino acids, between about 300 amino acids to about 480 amino acids, between about 300 amino acids to about 470 amino acids, between about 300 amino acids to about 460 amino acids, between about 300 amino acids to about 450 amino acids, between about 300 amino acids to about 440 amino acids, between about 300 amino acids to about 430 amino acids, between about 300 amino acids to about 420 amino acids, between about 300 amino acids to about 410 amino acids, between about 300 amino acids to about 400 amino acids, between about 300 amino acids to about 390 amino acids, between about 300 amino acids to about 380 amino acids, between about 300 amino acids to about 370 amino acids, between about 300 amino acids to about 360 amino acids, between about 300 amino acids to about 350 amino acids, between about 300 amino acids to about 340 amino acids, between about 300 amino acids to about 330 amino acids, between about 300 amino acids to about 320 amino acids, between about 300 amino acids to about 310 amino acids, between about 350 amino acids to about 800 amino acids, between about 350 amino acids to about 790 amino acids, between about 350 amino acids to about 780 amino acids, between about 350 amino acids to about 770 amino acids, between about 350 amino acids to about 760 amino acids, between about 350 amino acids to about 750 amino acids, between about 350 amino acids to about 740 amino acids, between about 350 amino acids to about 730 amino acids, between about 350 amino acids to about 720 amino acids, between about 350 amino acids to about 710 amino acids, between about 350 amino acids to about 700 amino acids, between about 350 amino acids to about 690 amino acids, between about 350 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 350 amino acids to about 660 amino acids, between about 350 amino acids to about 650 amino acids, between about 350 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 350 amino acids to about 620 amino acids, between about 350 amino acids to about 610 amino acids, between about 350 amino acids to about 600 amino acids, between about 350 amino acids to about 590 amino acids, between about 350 amino acids to about 580 amino acids, between about 350 amino acids to about 570 amino acids, between about 350 amino acids to about 560 amino acids, between about 350 amino acids to about 550 amino acids, between about 350 amino acids to about 540 amino acids, between about 350 amino acids to about 530 amino acids, between about 350 amino acids to about 520 amino acids, between about 350 amino acids to about 510 amino acids, between about 350 amino acids to about 500 amino acids, between about 350 amino acids to about 490 amino acids, between about 350 amino acids to about 480 amino acids, between about 350 amino acids to about 470 amino acids, between about 350 amino acids to about 460 amino acids, between about 350 amino acids to about 450 amino acids, between about 350 amino acids to about 440 amino acids, between about 350 amino acids to about 430 amino acids, between about 350 amino acids to about 420 amino acids, between about 350 amino acids to about 410 amino acids, between about 350 amino acids to about 400 amino acids, between about 350 amino acids to about 390 amino acids, between about 350 amino acids to about 380 amino acids, between about 350 amino acids to about 370 amino acids, between about 350 amino acids to about 360 amino acids, between about 380 amino acids to about 800 amino acids, between about 380 amino acids to about 790 amino acids, between about 380 amino acids to about 780 amino acids, between about 380 amino acids to about 770 amino acids, between about 380 amino acids to about 760 amino acids, between about 380 amino acids to about 750 amino acids, between about 380 amino acids to about 740 amino acids, between about 380 amino acids to about 730 amino acids, between about 380 amino acids to about 720 amino acids, between about 380 amino acids to about 710 amino acids, between about 380 amino acids to about 700 amino acids, between about 380 amino acids to about 690 amino acids, between about 380 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 380 amino acids to about 660 amino acids, between about 380 amino acids to about 650 amino acids, between about 380 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 380 amino acids to about 620 amino acids, between about 380 amino acids to about 610 amino acids, between about 380 amino acids to about 600 amino acids, between about 380 amino acids to about 590 amino acids, between about 380 amino acids to about 580 amino acids, between about 380 amino acids to about 570 amino acids, between about 380 amino acids to about 560 amino acids, between about 380 amino acids to about 550 amino acids, between about 380 amino acids to about 540 amino acids, between about 380 amino acids to about 530 amino acids, between about 380 amino acids to about 520 amino acids, between about 380 amino acids to about 510 amino acids, between about 380 amino acids to about 500 amino acids, between about 380 amino acids to about 490 amino acids, between about 380 amino acids to about 480 amino acids, between about 380 amino acids to about 470 amino acids, between about 380 amino acids to about 460 amino acids, between about 380 amino acids to about 450 amino acids, between about 380 amino acids to about 440 amino acids, between about 380 amino acids to about 430 amino acids, between about 380 amino acids to about 420 amino acids, between about 380 amino acids to about 410 amino acids, between about 380 amino acids to about 400 amino acids, between about 380 amino acids to about 390 amino acids, between about 400 amino acids to about 800 amino acids, between about 400 amino acids to about 790 amino acids, between about 400 amino acids to about 780 amino acids, between about 400 amino acids to about 770 amino acids, between about 400 amino acids to about 760 amino acids, between about 400 amino acids to about 750 amino acids, between about 400 amino acids to about 740 amino acids, between about 400 amino acids to about 730 amino acids, between about 400 amino acids to about 720 amino acids, between about 400 amino acids to about 710 amino acids, between about 400 amino acids to about 700 amino acids, between about 400 amino acids to about 690 amino acids, between about 400 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 400 amino acids to about 660 amino acids, between about 400 amino acids to about 650 amino acids, between about 400 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 400 amino acids to about 620 amino acids, between about 400 amino acids to about 610 amino acids, between about 400 amino acids to about 600 amino acids, between about 400 amino acids to about 590 amino acids, between about 400 amino acids to about 580 amino acids, between about 400 amino acids to about 570 amino acids, between about 400 amino acids to about 560 amino acids, between about 400 amino acids to about 550 amino acids, between about 400 amino acids to about 540 amino acids, between about 400 amino acids to about 530 amino acids, between about 400 amino acids to about 520 amino acids, between about 400 amino acids to about 510 amino acids, between about 400 amino acids to about 500 amino acids, between about 400 amino acids to about 490 amino acids, between about 400 amino acids to about 480 amino acids, between about 400 amino acids to about 470 amino acids, between about 400 amino acids to about 460 amino acids, between about 400 amino acids to about 450 amino acids, between about 400 amino acids to about 440 amino acids, between about 400 amino acids to about 430 amino acids, between about 400 amino acids to about 420 amino acids, between about 400 amino acids to about 410 amino acids, between about 450 amino acids to about 800 amino acids, between about 450 amino acids to about 790 amino acids, between about 450 amino acids to about 780 amino acids, between about 450 amino acids to about 770 amino acids, between about 450 amino acids to about 760 amino acids, between about 450 amino acids to about 750 amino acids, between about 450 amino acids to about 740 amino acids, between about 450 amino acids to about 730 amino acids, between about 450 amino acids to about 720 amino acids, between about 450 amino acids to about 710 amino acids, between about 450 amino acids to about 700 amino acids, between about 450 amino acids to about 690 amino acids, between about 450 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 450 amino acids to about 660 amino acids, between about 450 amino acids to about 650 amino acids, between about 450 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 450 amino acids to about 620 amino acids, between about 450 amino acids to about 610 amino acids, between about 450 amino acids to about 600 amino acids, between about 450 amino acids to about 590 amino acids, between about 450 amino acids to about 580 amino acids, between about 450 amino acids to about 570 amino acids, between about 450 amino acids to about 560 amino acids, between about 450 amino acids to about 550 amino acids, between about 450 amino acids to about 540 amino acids, between about 450 amino acids to about 530 amino acids, between about 450 amino acids to about 520 amino acids, between about 450 amino acids to about 510 amino acids, between about 450 amino acids to about 500 amino acids, between about 450 amino acids to about 490 amino acids, between about 450 amino acids to about 480 amino acids, between about 450 amino acids to about 470 amino acids, between about 450 amino acids to about 460 amino acids, between about 480 amino acids to about 800 amino acids, between about 480 amino acids to about 790 amino acids, between about 480 amino acids to about 780 amino acids, between about 480 amino acids to about 770 amino acids, between about 480 amino acids to about 760 amino acids, between about 480 amino acids to about 750 amino acids, between about 480 amino acids to about 740 amino acids, between about 480 amino acids to about 730 amino acids, between about 480 amino acids to about 720 amino acids, between about 480 amino acids to about 710 amino acids, between about 480 amino acids to about 700 amino acids, between about 480 amino acids to about 690 amino acids, between about 480 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 480 amino acids to about 660 amino acids, between about 480 amino acids to about 650 amino acids, between about 480 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 480 amino acids to about 620 amino acids, between about 480 amino acids to about 610 amino acids, between about 480 amino acids to about 600 amino acids, between about 480 amino acids to about 590 amino acids, between about 480 amino acids to about 580 amino acids, between about 480 amino acids to about 570 amino acids, between about 480 amino acids to about 560 amino acids, between about 480 amino acids to about 550 amino acids, between about 480 amino acids to about 540 amino acids, between about 480 amino acids to about 530 amino acids, between about 480 amino acids to about 520 amino acids, between about 480 amino acids to about 510 amino acids, between about 480 amino acids to about 500 amino acids, between about 480 amino acids to about 490 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 550 amino acids to about 800 amino acids, between about 550 amino acids to about 790 amino acids, between about 550 amino acids to about 780 amino acids, between about 550 amino acids to about 770 amino acids, between about 550 amino acids to about 760 amino acids, between about 550 amino acids to about 750 amino acids, between about 550 amino acids to about 740 amino acids, between about 550 amino acids to about 730 amino acids, between about 550 amino acids to about 720 amino acids, between about 550 amino acids to about 710 amino acids, between about 550 amino acids to about 700 amino acids, between about 550 amino acids to about 690 amino acids, between about 550 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 550 amino acids to about 660 amino acids, between about 550 amino acids to about 650 amino acids, between about 550 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 550 amino acids to about 620 amino acids, between about 550 amino acids to about 610 amino acids, between about 550 amino acids to about 600 amino acids, between about 550 amino acids to about 590 amino acids, between about 550 amino acids to about 580 amino acids, between about 550 amino acids to about 570 amino acids, between about 550 amino acids to about 560 amino acids, between about 580 amino acids to about 800 amino acids, between about 580 amino acids to about 790 amino acids, between about 580 amino acids to about 780 amino acids, between about 580 amino acids to about 770 amino acids, between about 580 amino acids to about 760 amino acids, between about 580 amino acids to about 750 amino acids, between about 580 amino acids to about 740 amino acids, between about 580 amino acids to about 730 amino acids, between about 580 amino acids to about 720 amino acids, between about 580 amino acids to about 710 amino acids, between about 580 amino acids to about 700 amino acids, between about 580 amino acids to about 690 amino acids, between about 580 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 580 amino acids to about 660 amino acids, between about 580 amino acids to about 650 amino acids, between about 580 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 580 amino acids to about 620 amino acids, between about 580 amino acids to about 610 amino acids, between about 580 amino acids to about 600 amino acids, between about 580 amino acids to about 590 amino acids, between about 600 amino acids to about 800 amino acids, between about 600 amino acids to about 790 amino acids, between about 600 amino acids to about 780 amino acids, between about 600 amino acids to about 770 amino acids, between about 600 amino acids to about 760 amino acids, between about 600 amino acids to about 750 amino acids, between about 600 amino acids to about 740 amino acids, between about 600 amino acids to about 730 amino acids, between about 600 amino acids to about 720 amino acids, between about 600 amino acids to about 710 amino acids, between about 600 amino acids to about 700 amino acids, between about 600 amino acids to about 690 amino acids, between about 600 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 600 amino acids to about 660 amino acids, between about 600 amino acids to about 650 amino acids, between about 600 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 600 amino acids to about 620 amino acids, between about 600 amino acids to about 610 amino acids, between about 650 amino acids to about 800 amino acids, between about 650 amino acids to about 790 amino acids, between about 650 amino acids to about 780 amino acids, between about 650 amino acids to about 770 amino acids, between about 650 amino acids to about 760 amino acids, between about 650 amino acids to about 750 amino acids, between about 650 amino acids to about 740 amino acids, between about 650 amino acids to about 730 amino acids, between about 650 amino acids to about 720 amino acids, between about 650 amino acids to about 710 amino acids, between about 650 amino acids to about 700 amino acids, between about 650 amino acids to about 690 amino acids, between about 650 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 650 amino acids to about 660 amino acids, between about 680 amino acids to about 800 amino acids, between about 680 amino acids to about 790 amino acids, between about 680 amino acids to about 780 amino acids, between about 680 amino acids to about 770 amino acids, between about 680 amino acids to about 760 amino acids, between about 680 amino acids to about 750 amino acids, between about 680 amino acids to about 740 amino acids, between about 680 amino acids to about 730 amino acids, between about 680 amino acids to about 720 amino acids, between about 680 amino acids to about 710 amino acids, between about 680 amino acids to about 700 amino acids, between about 680 amino acids to about 690 amino acids, between about 700 amino acids to about 800 amino acids, between about 700 amino acids to about 790 amino acids, between about 700 amino acids to about 780 amino acids, between about 700 amino acids to about 770 amino acids, between about 700 amino acids to about 760 amino acids, between about 700 amino acids to about 750 amino acids, between about 700 amino acids to about 740 amino acids, between about 700 amino acids to about 730 amino acids, between about 700 amino acids to about 720 amino acids, between about 700 amino acids to about 710 amino acids, between about 750 amino acids to about 800 amino acids, between about 750 amino acids to about 790 amino acids, between about 750 amino acids to about 780 amino acids, between about 750 amino acids to about 770 amino acids, between about 750 amino acids to about 760 amino acids, or between about 780 amino acids to about 800 amino acids) in length. In some examples, the first vector further includes one or both of a promoter (e.g., any of the promoters described herein or known in the art) and a Kozak sequence (e.g., any of the exemplary Kozak sequences described herein or known in the art). In some examples, the first vector includes a promoter that is an inducible promoter, a constitutive promoter, or a tissue-specific promoter. In some examples, the second of the two different vectors includes a coding sequence that encodes a C-terminal portion of the target protein (e.g., a C-terminal portion of the supporting cell target protein or a C-terminal portion of the hair cell target protein). In some examples, the C-terminal portion of the target protein (e.g., the C-terminal portion of the supporting cell target protein or the C-terminal portion of the hair cell target protein) is between about 30 amino acids to about 800 amino acids (e.g., between about 30 amino acids to about 790 amino acids, between about 30 amino acids to about 780 amino acids, between about 30 amino acids to about 770 amino acids, between about 30 amino acids to about 760 amino acids, between about 30 amino acids to about 750 amino acids, between about 30 amino acids to about 740 amino acids, between about 30 amino acids to about 730 amino acids, between about 30 amino acids to about 720 amino acids, between about 30 amino acids to about 710 amino acids, between about 30 amino acids to about 700 amino acids, between about 30 amino acids to about 690 amino acids, between about 30 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 30 amino acids to about 660 amino acids, between about 30 amino acids to about 650 amino acids, between about 30 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 30 amino acids to about 620 amino acids, between about 30 amino acids to about 610 amino acids, between about 30 amino acids to about 600 amino acids, between about 30 amino acids to about 590 amino acids, between about 30 amino acids to about 580 amino acids, between about 30 amino acids to about 570 amino acids, between about 30 amino acids to about 560 amino acids, between about 30 amino acids to about 550 amino acids, between about 30 amino acids to about 540 amino acids, between about 30 amino acids to about 530 amino acids, between about 30 amino acids to about 520 amino acids, between about 30 amino acids to about 510 amino acids, between about 30 amino acids to about 500 amino acids, between about 30 amino acids to about 490 amino acids, between about 30 amino acids to about 480 amino acids, between about 30 amino acids to about 470 amino acids, between about 30 amino acids to about 460 amino acids, between about 30 amino acids to about 450 amino acids, between about 30 amino acids to about 440 amino acids, between about 30 amino acids to about 430 amino acids, between about 30 amino acids to about 420 amino acids, between about 30 amino acids to about 410 amino acids, between about 30 amino acids to about 400 amino acids, between about 30 amino acids to about 390 amino acids, between about 30 amino acids to about 380 amino acids, between about 30 amino acids to about 370 amino acids, between about 30 amino acids to about 360 amino acids, between about 30 amino acids to about 350 amino acids, between about 30 amino acids to about 340 amino acids, between about 30 amino acids to about 330 amino acids, between about 30 amino acids to about 320 amino acids, between about 30 amino acids to about 310 amino acids, between about 30 amino acids to about 300 amino acids, between about 30 amino acids to about 290 amino acids, between about 30 amino acids to about 280 amino acids, between about 30 amino acids to about 270 amino acids, between about 30 amino acids to about 260 amino acids, between about 30 amino acids to about 250 amino acids, between about 30 amino acids to about 240 amino acids, between about 30 amino acids to about 230 amino acids, between about 30 amino acids to about 220 amino acids, between about 30 amino acids to about 210 amino acids, between about 30 amino acids to about 200 amino acids, between about 30 amino acids to about 190 amino acids, between about 30 amino acids to about 180 amino acids, between about 30 amino acids to about 170 amino acids, between about 30 amino acids to about 160 amino acids, between about 30 amino acids to about 150 amino acids, between about 30 amino acids to about 140 amino acids, between about 30 amino acids to about 130 amino acids, between about 30 amino acids to about 120 amino acids, between about 30 amino acids to about 110 amino acids, between about 30 amino acids to about 100 amino acids, between about 30 amino acids to about 90 amino acids, between about 30 amino acids to about 80 amino acids, between about 30 amino acids to about 70 amino acids, between about 30 amino acids to about 60 amino acids, between about 30 amino acids to about 50 amino acids, between about 30 amino acids to about 40 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 50 amino acids to about 500 amino acids, between about 50 amino acids to about 490 amino acids, between about 50 amino acids to about 480 amino acids, between about 50 amino acids to about 470 amino acids, between about 50 amino acids to about 460 amino acids, between about 50 amino acids to about 450 amino acids, between about 50 amino acids to about 440 amino acids, between about 50 amino acids to about 430 amino acids, between about 50 amino acids to about 420 amino acids, between about 50 amino acids to about 410 amino acids, between about 50 amino acids to about 400 amino acids, between about 50 amino acids to about 390 amino acids, between about 50 amino acids to about 380 amino acids, between about 50 amino acids to about 370 amino acids, between about 50 amino acids to about 360 amino acids, between about 50 amino acids to about 350 amino acids, between about 50 amino acids to about 340 amino acids, between about 50 amino acids to about 330 amino acids, between about 50 amino acids to about 320 amino acids, between about 50 amino acids to about 310 amino acids, between about 50 amino acids to about 300 amino acids, between about 50 amino acids to about 290 amino acids, between about 50 amino acids to about 280 amino acids, between about 50 amino acids to about 270 amino acids, between about 50 amino acids to about 260 amino acids, between about 50 amino acids to about 250 amino acids, between about 50 amino acids to about 240 amino acids, between about 50 amino acids to about 230 amino acids, between about 50 amino acids to about 220 amino acids, between about 50 amino acids to about 210 amino acids, between about 50 amino acids to about 200 amino acids, between about 50 amino acids to about 190 amino acids, between about 50 amino acids to about 180 amino acids, between about 50 amino acids to about 170 amino acids, between about 50 amino acids to about 160 amino acids, between about 50 amino acids to about 150 amino acids, between about 50 amino acids to about 140 amino acids, between about 50 amino acids to about 130 amino acids, between about 50 amino acids to about 120 amino acids, between about 50 amino acids to about 110 amino acids, between about 50 amino acids to about 100 amino acids, between about 50 amino acids to about 90 amino acids, between about 50 amino acids to about 80 amino acids, between about 50 amino acids to about 70 amino acids, between about 50 amino acids to about 60 amino acids, between about 80 amino acids to about 800 amino acids, between about 80 amino acids to about 790 amino acids, between about 80 amino acids to about 780 amino acids, between about 80 amino acids to about 770 amino acids, between about 80 amino acids to about 760 amino acids, between about 80 amino acids to about 750 amino acids, between about 80 amino acids to about 740 amino acids, between about 80 amino acids to about 730 amino acids, between about 80 amino acids to about 720 amino acids, between about 80 amino acids to about 710 amino acids, between about 80 amino acids to about 700 amino acids, between about 80 amino acids to about 690 amino acids, between about 80 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 80 amino acids to about 660 amino acids, between about 80 amino acids to about 650 amino acids, between about 80 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 80 amino acids to about 620 amino acids, between about 80 amino acids to about 610 amino acids, between about 80 amino acids to about 600 amino acids, between about 80 amino acids to about 590 amino acids, between about 80 amino acids to about 580 amino acids, between about 80 amino acids to about 570 amino acids, between about 80 amino acids to about 560 amino acids, between about 80 amino acids to about 550 amino acids, between about 80 amino acids to about 540 amino acids, between about 80 amino acids to about 530 amino acids, between about 80 amino acids to about 520 amino acids, between about 80 amino acids to about 510 amino acids, between about 80 amino acids to about 500 amino acids, between about 80 amino acids to about 490 amino acids, between about 80 amino acids to about 480 amino acids, between about 80 amino acids to about 470 amino acids, between about 80 amino acids to about 460 amino acids, between about 80 amino acids to about 450 amino acids, between about 80 amino acids to about 440 amino acids, between about 80 amino acids to about 430 amino acids, between about 80 amino acids to about 420 amino acids, between about 80 amino acids to about 410 amino acids, between about 80 amino acids to about 400 amino acids, between about 80 amino acids to about 390 amino acids, between about 80 amino acids to about 380 amino acids, between about 80 amino acids to about 370 amino acids, between about 80 amino acids to about 360 amino acids, between about 80 amino acids to about 350 amino acids, between about 80 amino acids to about 340 amino acids, between about 80 amino acids to about 330 amino acids, between about 80 amino acids to about 320 amino acids, between about 80 amino acids to about 310 amino acids, between about 80 amino acids to about 300 amino acids, between about 80 amino acids to about 290 amino acids, between about 80 amino acids to about 280 amino acids, between about 80 amino acids to about 270 amino acids, between about 80 amino acids to about 260 amino acids, between about 80 amino acids to about 250 amino acids, between about 80 amino acids to about 240 amino acids, between about 80 amino acids to about 230 amino acids, between about 80 amino acids to about 220 amino acids, between about 80 amino acids to about 210 amino acids, between about 80 amino acids to about 200 amino acids, between about 80 amino acids to about 190 amino acids, between about 80 amino acids to about 180 amino acids, between about 80 amino acids to about 170 amino acids, between about 80 amino acids to about 160 amino acids, between about 80 amino acids to about 150 amino acids, between about 80 amino acids to about 140 amino acids, between about 80 amino acids to about 130 amino acids, between about 80 amino acids to about 120 amino acids, between about 80 amino acids to about 110 amino acids, between about 80 amino acids to about 100 amino acids, between about 100 amino acids to about 800 amino acids, between about 100 amino acids to about 790 amino acids, between about 100 amino acids to about 780 amino acids, between about 100 amino acids to about 770 amino acids, between about 100 amino acids to about 760 amino acids, between about 100 amino acids to about 750 amino acids, between about 100 amino acids to about 740 amino acids, between about 100 amino acids to about 730 amino acids, between about 100 amino acids to about 720 amino acids, between about 100 amino acids to about 710 amino acids, between about 100 amino acids to about 700 amino acids, between about 100 amino acids to about 690 amino acids, between about 100 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 100 amino acids to about 660 amino acids, between about 100 amino acids to about 650 amino acids, between about 100 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 100 amino acids to about 620 amino acids, between about 100 amino acids to about 610 amino acids, between about 100 amino acids to about 600 amino acids, between about 100 amino acids to about 590 amino acids, between about 100 amino acids to about 580 amino acids, between about 100 amino acids to about 570 amino acids, between about 100 amino acids to about 560 amino acids, between about 100 amino acids to about 550 amino acids, between about 100 amino acids to about 540 amino acids, between about 100 amino acids to about 530 amino acids, between about 100 amino acids to about 520 amino acids, between about 100 amino acids to about 510 amino acids, between about 100 amino acids to about 500 amino acids, between about 100 amino acids to about 490 amino acids, between about 100 amino acids to about 480 amino acids, between about 100 amino acids to about 470 amino acids, between about 100 amino acids to about 460 amino acids, between about 100 amino acids to about 450 amino acids, between about 100 amino acids to about 440 amino acids, between about 100 amino acids to about 430 amino acids, between about 100 amino acids to about 420 amino acids, between about 100 amino acids to about 410 amino acids, between about 100 amino acids to about 400 amino acids, between about 100 amino acids to about 390 amino acids, between about 100 amino acids to about 380 amino acids, between about 100 amino acids to about 370 amino acids, between about 100 amino acids to about 360 amino acids, between about 100 amino acids to about 350 amino acids, between about 100 amino acids to about 340 amino acids, between about 100 amino acids to about 330 amino acids, between about 100 amino acids to about 320 amino acids, between about 100 amino acids to about 310 amino acids, between about 100 amino acids to about 300 amino acids, between about 100 amino acids to about 290 amino acids, between about 100 amino acids to about 280 amino acids, between about 100 amino acids to about 270 amino acids, between about 100 amino acids to about 260 amino acids, between about 100 amino acids to about 250 amino acids, between about 100 amino acids to about 240 amino acids, between about 100 amino acids to about 230 amino acids, between about 100 amino acids to about 220 amino acids, between about 100 amino acids to about 210 amino acids, between about 100 amino acids to about 200 amino acids, between about 100 amino acids to about 190 amino acids, between about 100 amino acids to about 180 amino acids, between about 100 amino acids to about 170 amino acids, between about 100 amino acids to about 160 amino acids, between about 100 amino acids to about 150 amino acids, between about 100 amino acids to about 140 amino acids, between about 100 amino acids to about 130 amino acids, between about 100 amino acids to about 120 amino acids, between about 100 amino acids to about 110 amino acids, between about 120 amino acids to about 800 amino acids, between about 120 amino acids to about 790 amino acids, between about 120 amino acids to about 780 amino acids, between about 120 amino acids to about 770 amino acids, between about 120 amino acids to about 760 amino acids, between about 120 amino acids to about 750 amino acids, between about 120 amino acids to about 740 amino acids, between about 120 amino acids to about 730 amino acids, between about 120 amino acids to about 720 amino acids, between about 120 amino acids to about 710 amino acids, between about 120 amino acids to about 700 amino acids, between about 120 amino acids to about 690 amino acids, between about 120 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 120 amino acids to about 660 amino acids, between about 120 amino acids to about 650 amino acids, between about 120 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 120 amino acids to about 620 amino acids, between about 120 amino acids to about 610 amino acids, between about 120 amino acids to about 600 amino acids, between about 120 amino acids to about 590 amino acids, between about 120 amino acids to about 580 amino acids, between about 120 amino acids to about 570 amino acids, between about 120 amino acids to about 560 amino acids, between about 120 amino acids to about 550 amino acids, between about 120 amino acids to about 540 amino acids, between about 120 amino acids to about 530 amino acids, between about 120 amino acids to about 520 amino acids, between about 120 amino acids to about 510 amino acids, between about 120 amino acids to about 500 amino acids, between about 120 amino acids to about 490 amino acids, between about 120 amino acids to about 480 amino acids, between about 120 amino acids to about 470 amino acids, between about 120 amino acids to about 460 amino acids, between about 120 amino acids to about 450 amino acids, between about 120 amino acids to about 440 amino acids, between about 120 amino acids to about 430 amino acids, between about 120 amino acids to about 420 amino acids, between about 120 amino acids to about 410 amino acids, between about 120 amino acids to about 400 amino acids, between about 120 amino acids to about 390 amino acids, between about 120 amino acids to about 380 amino acids, between about 120 amino acids to about 370 amino acids, between about 120 amino acids to about 360 amino acids, between about 120 amino acids to about 350 amino acids, between about 120 amino acids to about 340 amino acids, between about 120 amino acids to about 330 amino acids, between about 120 amino acids to about 320 amino acids, between about 120 amino acids to about 310 amino acids, between about 120 amino acids to about 300 amino acids, between about 120 amino acids to about 290 amino acids, between about 120 amino acids to about 280 amino acids, between about 120 amino acids to about 270 amino acids, between about 120 amino acids to about 260 amino acids, between about 120 amino acids to about 250 amino acids, between about 120 amino acids to about 240 amino acids, between about 120 amino acids to about 230 amino acids, between about 120 amino acids to about 220 amino acids, between about 120 amino acids to about 210 amino acids, between about 120 amino acids to about 200 amino acids, between about 120 amino acids to about 190 amino acids, between about 120 amino acids to about 180 amino acids, between about 120 amino acids to about 170 amino acids, between about 120 amino acids to about 160 amino acids, between about 120 amino acids to about 150 amino acids, between about 120 amino acids to about 140 amino acids, between about 120 amino acids to about 130 amino acids, between about 150 amino acids to about 800 amino acids, between about 150 amino acids to about 790 amino acids, between about 150 amino acids to about 780 amino acids, between about 150 amino acids to about 770 amino acids, between about 150 amino acids to about 760 amino acids, between about 150 amino acids to about 750 amino acids, between about 150 amino acids to about 740 amino acids, between about 150 amino acids to about 730 amino acids, between about 150 amino acids to about 720 amino acids, between about 150 amino acids to about 710 amino acids, between about 150 amino acids to about 700 amino acids, between about 150 amino acids to about 690 amino acids, between about 150 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 150 amino acids to about 660 amino acids, between about 150 amino acids to about 650 amino acids, between about 150 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 150 amino acids to about 620 amino acids, between about 150 amino acids to about 610 amino acids, between about 150 amino acids to about 600 amino acids, between about 150 amino acids to about 590 amino acids, between about 150 amino acids to about 580 amino acids, between about 150 amino acids to about 570 amino acids, between about 150 amino acids to about 560 amino acids, between about 150 amino acids to about 550 amino acids, between about 150 amino acids to about 540 amino acids, between about 150 amino acids to about 530 amino acids, between about 150 amino acids to about 520 amino acids, between about 150 amino acids to about 510 amino acids, between about 150 amino acids to about 500 amino acids, between about 150 amino acids to about 490 amino acids, between about 150 amino acids to about 480 amino acids, between about 150 amino acids to about 470 amino acids, between about 150 amino acids to about 460 amino acids, between about 150 amino acids to about 450 amino acids, between about 150 amino acids to about 440 amino acids, between about 150 amino acids to about 430 amino acids, between about 150 amino acids to about 420 amino acids, between about 150 amino acids to about 410 amino acids, between about 150 amino acids to about 400 amino acids, between about 150 amino acids to about 390 amino acids, between about 150 amino acids to about 380 amino acids, between about 150 amino acids to about 370 amino acids, between about 150 amino acids to about 360 amino acids, between about 150 amino acids to about 350 amino acids, between about 150 amino acids to about 340 amino acids, between about 150 amino acids to about 330 amino acids, between about 150 amino acids to about 320 amino acids, between about 150 amino acids to about 310 amino acids, between about 150 amino acids to about 300 amino acids, between about 150 amino acids to about 290 amino acids, between about 150 amino acids to about 280 amino acids, between about 150 amino acids to about 270 amino acids, between about 150 amino acids to about 260 amino acids, between about 150 amino acids to about 250 amino acids, between about 150 amino acids to about 240 amino acids, between about 150 amino acids to about 230 amino acids, between about 150 amino acids to about 220 amino acids, between about 150 amino acids to about 210 amino acids, between about 150 amino acids to about 200 amino acids, between about 150 amino acids to about 190 amino acids, between about 150 amino acids to about 180 amino acids, between about 150 amino acids to about 170 amino acids, between about 150 amino acids to about 160 amino acids, between about 180 amino acids to about 800 amino acids, between about 180 amino acids to about 790 amino acids, between about 180 amino acids to about 780 amino acids, between about 180 amino acids to about 770 amino acids, between about 180 amino acids to about 760 amino acids, between about 180 amino acids to about 750 amino acids, between about 180 amino acids to about 740 amino acids, between about 180 amino acids to about 730 amino acids, between about 180 amino acids to about 720 amino acids, between about 180 amino acids to about 710 amino acids, between about 180 amino acids to about 700 amino acids, between about 180 amino acids to about 690 amino acids, between about 180 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 180 amino acids to about 660 amino acids, between about 180 amino acids to about 650 amino acids, between about 180 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 180 amino acids to about 620 amino acids, between about 180 amino acids to about 610 amino acids, between about 180 amino acids to about 600 amino acids, between about 180 amino acids to about 590 amino acids, between about 180 amino acids to about 580 amino acids, between about 180 amino acids to about 570 amino acids, between about 180 amino acids to about 560 amino acids, between about 180 amino acids to about 550 amino acids, between about 180 amino acids to about 540 amino acids, between about 180 amino acids to about 530 amino acids, between about 180 amino acids to about 520 amino acids, between about 180 amino acids to about 510 amino acids, between about 180 amino acids to about 500 amino acids, between about 180 amino acids to about 490 amino acids, between about 180 amino acids to about 480 amino acids, between about 180 amino acids to about 470 amino acids, between about 180 amino acids to about 460 amino acids, between about 180 amino acids to about 450 amino acids, between about 180 amino acids to about 440 amino acids, between about 180 amino acids to about 430 amino acids, between about 180 amino acids to about 420 amino acids, between about 180 amino acids to about 410 amino acids, between about 180 amino acids to about 400 amino acids, between about 180 amino acids to about 390 amino acids, between about 180 amino acids to about 380 amino acids, between about 180 amino acids to about 370 amino acids, between about 180 amino acids to about 360 amino acids, between about 180 amino acids to about 350 amino acids, between about 180 amino acids to about 340 amino acids, between about 180 amino acids to about 330 amino acids, between about 180 amino acids to about 320 amino acids, between about 180 amino acids to about 310 amino acids, between about 180 amino acids to about 300 amino acids, between about 180 amino acids to about 290 amino acids, between about 180 amino acids to about 280 amino acids, between about 180 amino acids to about 270 amino acids, between about 180 amino acids to about 260 amino acids, between about 180 amino acids to about 250 amino acids, between about 180 amino acids to about 240 amino acids, between about 180 amino acids to about 230 amino acids, between about 180 amino acids to about 220 amino acids, between about 180 amino acids to about 210 amino acids, between about 180 amino acids to about 200 amino acids, between about 180 amino acids to about 190 amino acids, between about 200 amino acids to about 800 amino acids, between about 200 amino acids to about 790 amino acids, between about 200 amino acids to about 780 amino acids, between about 200 amino acids to about 770 amino acids, between about 200 amino acids to about 760 amino acids, between about 200 amino acids to about 750 amino acids, between about 200 amino acids to about 740 amino acids, between about 200 amino acids to about 730 amino acids, between about 200 amino acids to about 720 amino acids, between about 200 amino acids to about 710 amino acids, between about 200 amino acids to about 700 amino acids, between about 200 amino acids to about 690 amino acids, between about 200 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 200 amino acids to about 660 amino acids, between about 200 amino acids to about 650 amino acids, between about 200 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 200 amino acids to about 620 amino acids, between about 200 amino acids to about 610 amino acids, between about 200 amino acids to about 600 amino acids, between about 200 amino acids to about 590 amino acids, between about 200 amino acids to about 580 amino acids, between about 200 amino acids to about 570 amino acids, between about 200 amino acids to about 560 amino acids, between about 200 amino acids to about 550 amino acids, between about 200 amino acids to about 540 amino acids, between about 200 amino acids to about 530 amino acids, between about 200 amino acids to about 520 amino acids, between about 200 amino acids to about 510 amino acids, between about 200 amino acids to about 500 amino acids, between about 200 amino acids to about 490 amino acids, between about 200 amino acids to about 480 amino acids, between about 200 amino acids to about 470 amino acids, between about 200 amino acids to about 460 amino acids, between about 200 amino acids to about 450 amino acids, between about 200 amino acids to about 440 amino acids, between about 200 amino acids to about 430 amino acids, between about 200 amino acids to about 420 amino acids, between about 200 amino acids to about 410 amino acids, between about 200 amino acids to about 400 amino acids, between about 200 amino acids to about 390 amino acids, between about 200 amino acids to about 380 amino acids, between about 200 amino acids to about 370 amino acids, between about 200 amino acids to about 360 amino acids, between about 200 amino acids to about 350 amino acids, between about 200 amino acids to about 340 amino acids, between about 200 amino acids to about 330 amino acids, between about 200 amino acids to about 320 amino acids, between about 200 amino acids to about 310 amino acids, between about 200 amino acids to about 300 amino acids, between about 200 amino acids to about 290 amino acids, between about 200 amino acids to about 280 amino acids, between about 200 amino acids to about 270 amino acids, between about 200 amino acids to about 260 amino acids, between about 200 amino acids to about 250 amino acids, between about 200 amino acids to about 240 amino acids, between about 200 amino acids to about 230 amino acids, between about 200 amino acids to about 220 amino acids, between about 200 amino acids to about 210 amino acids, between about 250 amino acids to about 800 amino acids, between about 250 amino acids to about 790 amino acids, between about 250 amino acids to about 780 amino acids, between about 250 amino acids to about 770 amino acids, between about 250 amino acids to about 760 amino acids, between about 250 amino acids to about 750 amino acids, between about 250 amino acids to about 740 amino acids, between about 250 amino acids to about 730 amino acids, between about 250 amino acids to about 720 amino acids, between about 250 amino acids to about 710 amino acids, between about 250 amino acids to about 700 amino acids, between about 250 amino acids to about 690 amino acids, between about 250 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 250 amino acids to about 660 amino acids, between about 250 amino acids to about 650 amino acids, between about 250 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 250 amino acids to about 620 amino acids, between about 250 amino acids to about 610 amino acids, between about 250 amino acids to about 600 amino acids, between about 250 amino acids to about 590 amino acids, between about 250 amino acids to about 580 amino acids, between about 250 amino acids to about 570 amino acids, between about 250 amino acids to about 560 amino acids, between about 250 amino acids to about 550 amino acids, between about 250 amino acids to about 540 amino acids, between about 250 amino acids to about 530 amino acids, between about 250 amino acids to about 520 amino acids, between about 250 amino acids to about 510 amino acids, between about 250 amino acids to about 500 amino acids, between about 250 amino acids to about 490 amino acids, between about 250 amino acids to about 480 amino acids, between about 250 amino acids to about 470 amino acids, between about 250 amino acids to about 460 amino acids, between about 250 amino acids to about 450 amino acids, between about 250 amino acids to about 440 amino acids, between about 250 amino acids to about 430 amino acids, between about 250 amino acids to about 420 amino acids, between about 250 amino acids to about 410 amino acids, between about 250 amino acids to about 400 amino acids, between about 250 amino acids to about 390 amino acids, between about 250 amino acids to about 380 amino acids, between about 250 amino acids to about 370 amino acids, between about 250 amino acids to about 360 amino acids, between about 250 amino acids to about 350 amino acids, between about 250 amino acids to about 340 amino acids, between about 250 amino acids to about 330 amino acids, between about 250 amino acids to about 320 amino acids, between about 250 amino acids to about 310 amino acids, between about 250 amino acids to about 300 amino acids, between about 250 amino acids to about 290 amino acids, between about 250 amino acids to about 280 amino acids, between about 250 amino acids to about 270 amino acids, between about 250 amino acids to about 260 amino acids, between about 280 amino acids to about 800 amino acids, between about 280 amino acids to about 790 amino acids, between about 280 amino acids to about 780 amino acids, between about 280 amino acids to about 770 amino acids, between about 280 amino acids to about 760 amino acids, between about 280 amino acids to about 750 amino acids, between about 280 amino acids to about 740 amino acids, between about 280 amino acids to about 730 amino acids, between about 280 amino acids to about 720 amino acids, between about 280 amino acids to about 710 amino acids, between about 280 amino acids to about 700 amino acids, between about 280 amino acids to about 690 amino acids, between about 280 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 280 amino acids to about 660 amino acids, between about 280 amino acids to about 650 amino acids, between about 280 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 280 amino acids to about 620 amino acids, between about 280 amino acids to about 610 amino acids, between about 280 amino acids to about 600 amino acids, between about 280 amino acids to about 590 amino acids, between about 280 amino acids to about 580 amino acids, between about 280 amino acids to about 570 amino acids, between about 280 amino acids to about 560 amino acids, between about 280 amino acids to about 550 amino acids, between about 280 amino acids to about 540 amino acids, between about 280 amino acids to about 530 amino acids, between about 280 amino acids to about 520 amino acids, between about 280 amino acids to about 510 amino acids, between about 280 amino acids to about 500 amino acids, between about 280 amino acids to about 490 amino acids, between about 280 amino acids to about 480 amino acids, between about 280 amino acids to about 470 amino acids, between about 280 amino acids to about 460 amino acids, between about 280 amino acids to about 450 amino acids, between about 280 amino acids to about 440 amino acids, between about 280 amino acids to about 430 amino acids, between about 280 amino acids to about 420 amino acids, between about 280 amino acids to about 410 amino acids, between about 280 amino acids to about 400 amino acids, between about 280 amino acids to about 390 amino acids, between about 280 amino acids to about 380 amino acids, between about 280 amino acids to about 370 amino acids, between about 280 amino acids to about 360 amino acids, between about 280 amino acids to about 350 amino acids, between about 280 amino acids to about 340 amino acids, between about 280 amino acids to about 330 amino acids, between about 280 amino acids to about 320 amino acids, between about 280 amino acids to about 310 amino acids, between about 280 amino acids to about 300 amino acids, between about 300 amino acids to about 800 amino acids, between about 300 amino acids to about 790 amino acids, between about 300 amino acids to about 780 amino acids, between about 300 amino acids to about 770 amino acids, between about 300 amino acids to about 760 amino acids, between about 300 amino acids to about 750 amino acids, between about 300 amino acids to about 740 amino acids, between about 300 amino acids to about 730 amino acids, between about 300 amino acids to about 720 amino acids, between about 300 amino acids to about 710 amino acids, between about 300 amino acids to about 700 amino acids, between about 300 amino acids to about 690 amino acids, between about 300 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 300 amino acids to about 660 amino acids, between about 300 amino acids to about 650 amino acids, between about 300 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 300 amino acids to about 620 amino acids, between about 300 amino acids to about 610 amino acids, between about 300 amino acids to about 600 amino acids, between about 300 amino acids to about 590 amino acids, between about 300 amino acids to about 580 amino acids, between about 300 amino acids to about 570 amino acids, between about 300 amino acids to about 560 amino acids, between about 300 amino acids to about 550 amino acids, between about 300 amino acids to about 540 amino acids, between about 300 amino acids to about 530 amino acids, between about 300 amino acids to about 520 amino acids, between about 300 amino acids to about 510 amino acids, between about 300 amino acids to about 500 amino acids, between about 300 amino acids to about 490 amino acids, between about 300 amino acids to about 480 amino acids, between about 300 amino acids to about 470 amino acids, between about 300 amino acids to about 460 amino acids, between about 300 amino acids to about 450 amino acids, between about 300 amino acids to about 440 amino acids, between about 300 amino acids to about 430 amino acids, between about 300 amino acids to about 420 amino acids, between about 300 amino acids to about 410 amino acids, between about 300 amino acids to about 400 amino acids, between about 300 amino acids to about 390 amino acids, between about 300 amino acids to about 380 amino acids, between about 300 amino acids to about 370 amino acids, between about 300 amino acids to about 360 amino acids, between about 300 amino acids to about 350 amino acids, between about 300 amino acids to about 340 amino acids, between about 300 amino acids to about 330 amino acids, between about 300 amino acids to about 320 amino acids, between about 300 amino acids to about 310 amino acids, between about 350 amino acids to about 800 amino acids, between about 350 amino acids to about 790 amino acids, between about 350 amino acids to about 780 amino acids, between about 350 amino acids to about 770 amino acids, between about 350 amino acids to about 760 amino acids, between about 350 amino acids to about 750 amino acids, between about 350 amino acids to about 740 amino acids, between about 350 amino acids to about 730 amino acids, between about 350 amino acids to about 720 amino acids, between about 350 amino acids to about 710 amino acids, between about 350 amino acids to about 700 amino acids, between about 350 amino acids to about 690 amino acids, between about 350 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 350 amino acids to about 660 amino acids, between about 350 amino acids to about 650 amino acids, between about 350 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 350 amino acids to about 620 amino acids, between about 350 amino acids to about 610 amino acids, between about 350 amino acids to about 600 amino acids, between about 350 amino acids to about 590 amino acids, between about 350 amino acids to about 580 amino acids, between about 350 amino acids to about 570 amino acids, between about 350 amino acids to about 560 amino acids, between about 350 amino acids to about 550 amino acids, between about 350 amino acids to about 540 amino acids, between about 350 amino acids to about 530 amino acids, between about 350 amino acids to about 520 amino acids, between about 350 amino acids to about 510 amino acids, between about 350 amino acids to about 500 amino acids, between about 350 amino acids to about 490 amino acids, between about 350 amino acids to about 480 amino acids, between about 350 amino acids to about 470 amino acids, between about 350 amino acids to about 460 amino acids, between about 350 amino acids to about 450 amino acids, between about 350 amino acids to about 440 amino acids, between about 350 amino acids to about 430 amino acids, between about 350 amino acids to about 420 amino acids, between about 350 amino acids to about 410 amino acids, between about 350 amino acids to about 400 amino acids, between about 350 amino acids to about 390 amino acids, between about 350 amino acids to about 380 amino acids, between about 350 amino acids to about 370 amino acids, between about 350 amino acids to about 360 amino acids, between about 380 amino acids to about 800 amino acids, between about 380 amino acids to about 790 amino acids, between about 380 amino acids to about 780 amino acids, between about 380 amino acids to about 770 amino acids, between about 380 amino acids to about 760 amino acids, between about 380 amino acids to about 750 amino acids, between about 380 amino acids to about 740 amino acids, between about 380 amino acids to about 730 amino acids, between about 380 amino acids to about 720 amino acids, between about 380 amino acids to about 710 amino acids, between about 380 amino acids to about 700 amino acids, between about 380 amino acids to about 690 amino acids, between about 380 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 380 amino acids to about 660 amino acids, between about 380 amino acids to about 650 amino acids, between about 380 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 380 amino acids to about 620 amino acids, between about 380 amino acids to about 610 amino acids, between about 380 amino acids to about 600 amino acids, between about 380 amino acids to about 590 amino acids, between about 380 amino acids to about 580 amino acids, between about 380 amino acids to about 570 amino acids, between about 380 amino acids to about 560 amino acids, between about 380 amino acids to about 550 amino acids, between about 380 amino acids to about 540 amino acids, between about 380 amino acids to about 530 amino acids, between about 380 amino acids to about 520 amino acids, between about 380 amino acids to about 510 amino acids, between about 380 amino acids to about 500 amino acids, between about 380 amino acids to about 490 amino acids, between about 380 amino acids to about 480 amino acids, between about 380 amino acids to about 470 amino acids, between about 380 amino acids to about 460 amino acids, between about 380 amino acids to about 450 amino acids, between about 380 amino acids to about 440 amino acids, between about 380 amino acids to about 430 amino acids, between about 380 amino acids to about 420 amino acids, between about 380 amino acids to about 410 amino acids, between about 380 amino acids to about 400 amino acids, between about 380 amino acids to about 390 amino acids, between about 400 amino acids to about 800 amino acids, between about 400 amino acids to about 790 amino acids, between about 400 amino acids to about 780 amino acids, between about 400 amino acids to about 770 amino acids, between about 400 amino acids to about 760 amino acids, between about 400 amino acids to about 750 amino acids, between about 400 amino acids to about 740 amino acids, between about 400 amino acids to about 730 amino acids, between about 400 amino acids to about 720 amino acids, between about 400 amino acids to about 710 amino acids, between about 400 amino acids to about 700 amino acids, between about 400 amino acids to about 690 amino acids, between about 400 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 400 amino acids to about 660 amino acids, between about 400 amino acids to about 650 amino acids, between about 400 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 400 amino acids to about 620 amino acids, between about 400 amino acids to about 610 amino acids, between about 400 amino acids to about 600 amino acids, between about 400 amino acids to about 590 amino acids, between about 400 amino acids to about 580 amino acids, between about 400 amino acids to about 570 amino acids, between about 400 amino acids to about 560 amino acids, between about 400 amino acids to about 550 amino acids, between about 400 amino acids to about 540 amino acids, between about 400 amino acids to about 530 amino acids, between about 400 amino acids to about 520 amino acids, between about 400 amino acids to about 510 amino acids, between about 400 amino acids to about 500 amino acids, between about 400 amino acids to about 490 amino acids, between about 400 amino acids to about 480 amino acids, between about 400 amino acids to about 470 amino acids, between about 400 amino acids to about 460 amino acids, between about 400 amino acids to about 450 amino acids, between about 400 amino acids to about 440 amino acids, between about 400 amino acids to about 430 amino acids, between about 400 amino acids to about 420 amino acids, between about 400 amino acids to about 410 amino acids, between about 450 amino acids to about 800 amino acids, between about 450 amino acids to about 790 amino acids, between about 450 amino acids to about 780 amino acids, between about 450 amino acids to about 770 amino acids, between about 450 amino acids to about 760 amino acids, between about 450 amino acids to about 750 amino acids, between about 450 amino acids to about 740 amino acids, between about 450 amino acids to about 730 amino acids, between about 450 amino acids to about 720 amino acids, between about 450 amino acids to about 710 amino acids, between about 450 amino acids to about 700 amino acids, between about 450 amino acids to about 690 amino acids, between about 450 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 450 amino acids to about 660 amino acids, between about 450 amino acids to about 650 amino acids, between about 450 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 450 amino acids to about 620 amino acids, between about 450 amino acids to about 610 amino acids, between about 450 amino acids to about 600 amino acids, between about 450 amino acids to about 590 amino acids, between about 450 amino acids to about 580 amino acids, between about 450 amino acids to about 570 amino acids, between about 450 amino acids to about 560 amino acids, between about 450 amino acids to about 550 amino acids, between about 450 amino acids to about 540 amino acids, between about 450 amino acids to about 530 amino acids, between about 450 amino acids to about 520 amino acids, between about 450 amino acids to about 510 amino acids, between about 450 amino acids to about 500 amino acids, between about 450 amino acids to about 490 amino acids, between about 450 amino acids to about 480 amino acids, between about 450 amino acids to about 470 amino acids, between about 450 amino acids to about 460 amino acids, between about 480 amino acids to about 800 amino acids, between about 480 amino acids to about 790 amino acids, between about 480 amino acids to about 780 amino acids, between about 480 amino acids to about 770 amino acids, between about 480 amino acids to about 760 amino acids, between about 480 amino acids to about 750 amino acids, between about 480 amino acids to about 740 amino acids, between about 480 amino acids to about 730 amino acids, between about 480 amino acids to about 720 amino acids, between about 480 amino acids to about 710 amino acids, between about 480 amino acids to about 700 amino acids, between about 480 amino acids to about 690 amino acids, between about 480 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 480 amino acids to about 660 amino acids, between about 480 amino acids to about 650 amino acids, between about 480 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 480 amino acids to about 620 amino acids, between about 480 amino acids to about 610 amino acids, between about 480 amino acids to about 600 amino acids, between about 480 amino acids to about 590 amino acids, between about 480 amino acids to about 580 amino acids, between about 480 amino acids to about 570 amino acids, between about 480 amino acids to about 560 amino acids, between about 480 amino acids to about 550 amino acids, between about 480 amino acids to about 540 amino acids, between about 480 amino acids to about 530 amino acids, between about 480 amino acids to about 520 amino acids, between about 480 amino acids to about 510 amino acids, between about 480 amino acids to about 500 amino acids, between about 480 amino acids to about 490 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 550 amino acids to about 800 amino acids, between about 550 amino acids to about 790 amino acids, between about 550 amino acids to about 780 amino acids, between about 550 amino acids to about 770 amino acids, between about 550 amino acids to about 760 amino acids, between about 550 amino acids to about 750 amino acids, between about 550 amino acids to about 740 amino acids, between about 550 amino acids to about 730 amino acids, between about 550 amino acids to about 720 amino acids, between about 550 amino acids to about 710 amino acids, between about 550 amino acids to about 700 amino acids, between about 550 amino acids to about 690 amino acids, between about 550 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 550 amino acids to about 660 amino acids, between about 550 amino acids to about 650 amino acids, between about 550 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 550 amino acids to about 620 amino acids, between about 550 amino acids to about 610 amino acids, between about 550 amino acids to about 600 amino acids, between about 550 amino acids to about 590 amino acids, between about 550 amino acids to about 580 amino acids, between about 550 amino acids to about 570 amino acids, between about 550 amino acids to about 560 amino acids, between about 580 amino acids to about 800 amino acids, between about 580 amino acids to about 790 amino acids, between about 580 amino acids to about 780 amino acids, between about 580 amino acids to about 770 amino acids, between about 580 amino acids to about 760 amino acids, between about 580 amino acids to about 750 amino acids, between about 580 amino acids to about 740 amino acids, between about 580 amino acids to about 730 amino acids, between about 580 amino acids to about 720 amino acids, between about 580 amino acids to about 710 amino acids, between about 580 amino acids to about 700 amino acids, between about 580 amino acids to about 690 amino acids, between about 580 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 580 amino acids to about 660 amino acids, between about 580 amino acids to about 650 amino acids, between about 580 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 580 amino acids to about 620 amino acids, between about 580 amino acids to about 610 amino acids, between about 580 amino acids to about 600 amino acids, between about 580 amino acids to about 590 amino acids, between about 600 amino acids to about 800 amino acids, between about 600 amino acids to about 790 amino acids, between about 600 amino acids to about 780 amino acids, between about 600 amino acids to about 770 amino acids, between about 600 amino acids to about 760 amino acids, between about 600 amino acids to about 750 amino acids, between about 600 amino acids to about 740 amino acids, between about 600 amino acids to about 730 amino acids, between about 600 amino acids to about 720 amino acids, between about 600 amino acids to about 710 amino acids, between about 600 amino acids to about 700 amino acids, between about 600 amino acids to about 690 amino acids, between about 600 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 600 amino acids to about 660 amino acids, between about 600 amino acids to about 650 amino acids, between about 600 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 600 amino acids to about 620 amino acids, between about 600 amino acids to about 610 amino acids, between about 650 amino acids to about 800 amino acids, between about 650 amino acids to about 790 amino acids, between about 650 amino acids to about 780 amino acids, between about 650 amino acids to about 770 amino acids, between about 650 amino acids to about 760 amino acids, between about 650 amino acids to about 750 amino acids, between about 650 amino acids to about 740 amino acids, between about 650 amino acids to about 730 amino acids, between about 650 amino acids to about 720 amino acids, between about 650 amino acids to about 710 amino acids, between about 650 amino acids to about 700 amino acids, between about 650 amino acids to about 690 amino acids, between about 650 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 650 amino acids to about 660 amino acids, between about 680 amino acids to about 800 amino acids, between about 680 amino acids to about 790 amino acids, between about 680 amino acids to about 780 amino acids, between about 680 amino acids to about 770 amino acids, between about 680 amino acids to about 760 amino acids, between about 680 amino acids to about 750 amino acids, between about 680 amino acids to about 740 amino acids, between about 680 amino acids to about 730 amino acids, between about 680 amino acids to about 720 amino acids, between about 680 amino acids to about 710 amino acids, between about 680 amino acids to about 700 amino acids, between about 680 amino acids to about 690 amino acids, between about 700 amino acids to about 800 amino acids, between about 700 amino acids to about 790 amino acids, between about 700 amino acids to about 780 amino acids, between about 700 amino acids to about 770 amino acids, between about 700 amino acids to about 760 amino acids, between about 700 amino acids to about 750 amino acids, between about 700 amino acids to about 740 amino acids, between about 700 amino acids to about 730 amino acids, between about 700 amino acids to about 720 amino acids, between about 700 amino acids to about 710 amino acids, between about 750 amino acids to about 800 amino acids, between about 750 amino acids to about 790 amino acids, between about 750 amino acids to about 780 amino acids, between about 750 amino acids to about 770 amino acids, between about 750 amino acids to about 760 amino acids, or between about 780 amino acids to about 800 amino acids) in length. In some examples, the second vector further includes a poly(A) sequence.

[0234] In some examples where the number of different vectors in the composition is two, the N-terminal portion encoded by one of the two vectors can include a portion including amino acid position 1 to about amino acid position 800, about amino acid position 790, about amino acid position 780, about amino acid position 770, about amino acid position 760, about amino acid position 750, about amino acid position 740, about amino acid position 730, about amino acid position 720, about amino acid position 710, about amino acid position 700, about amino acid position 690, about amino acid position 680, about amino acid position 670, about amino acid position 660, about amino acid position 650, about amino acid position 640, about amino acid position 630, about amino acid position 620, about amino acid position 610, about amino acid position 600, about amino acid position 590, about amino acid position 580, about amino acid position 570, about amino acid position 560, about amino acid position 550, about amino acid position 540, about amino acid position 530, about amino acid position 520, about amino acid position 510, about amino acid position 500, about amino acid position 490, about amino acid position 480, about amino acid position 470, about amino acid position 460, about amino acid position 450, about amino acid position 440, about amino acid position 430, about amino acid position 420, about amino acid position 410, about amino acid position 400, about amino acid position 390, about amino acid position 380, about amino acid position 370, about amino acid position 360, about amino acid position 350, about amino acid position 340, about amino acid position 330, about amino acid position 320, about amino acid position 310, about amino acid position 300, about amino acid position 290, about amino acid position 280, about amino acid position 270, about amino acid position 260, about amino acid position 250, about amino acid position 240, about amino acid position 230, about amino acid position 220, about amino acid position 210, about amino acid position 200, about amino acid position 190, about amino acid position 180, about amino acid position 170, about amino acid position 160, about amino acid position 150, about amino acid position 140, about amino acid position 130, about amino acid position 120, about amino acid position 110, about amino acid position 100, about amino acid position 90, about amino acid position 80, about amino acid position 70, about amino acid position 60, about amino acid position 50, or about amino acid position 40 of a wildtype hair cell target protein (e.g., SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 20, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 39, SEQ ID NO: 41, SEQ ID NO: 43, SEQ ID NO: 45, SEQ ID NO: 48, SEQ ID NO: 51, SEQ ID NO: 53, SEQ ID NO: 55, SEQ ID NO: 57, SEQ ID NO: 59, SEQ ID NO: 61, SEQ ID NO: 64, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, or SEQ ID NO: 79).

[0235] In some examples where the number of different vectors in the composition is two, the N-terminal portion of the precursor hair cell target protein can include a portion including amino acid position 1 to amino acid position 300, amino acid position 1 to amino acid position 310, amino acid position 1 to about amino acid position 320, amino acid position 1 to about amino acid position 330, amino acid position 1 to about amino acid position 340, amino acid position 1 to about amino acid position 350, amino acid position 1 to about amino acid position 360, amino acid position 1 to about amino acid position 370, amino acid position 1 to about amino acid position 380, amino acid position 1 to about amino acid position 390, amino acid position 1 to about amino acid position 400, amino acid position 1 to about amino acid position 410, amino acid position 1 to about amino acid position 420, amino acid position 1 to about amino acid position 430, amino acid position 1 to about amino acid position 440, amino acid position 1 to about amino acid position 450, amino acid position 1 to about amino acid position 460, amino acid position 1 to about amino acid position 470, amino acid position 1 to about amino acid position 480, amino acid position 1 to about amino acid position 490, amino acid position 1 to about amino acid position 500, amino acid position 1 to about amino acid position 510, amino acid position 1 to about amino acid position 520, amino acid position 1 to about amino acid position 530, amino acid position 1 to about amino acid position 540, amino acid position 1 to about amino acid position 550, amino acid position 1 to about amino acid position 560, amino acid position 1 to about amino acid position 570, amino acid position 1 to about amino acid position 580, amino acid position 1 to about amino acid position 590, amino acid position 1 to about amino acid position 600, amino acid position 1 to about amino acid position 610, amino acid position 1 to about amino acid position 620, amino acid position 1 to about amino acid position 630, amino acid position 1 to about amino acid position 640, amino acid position 1 to about amino acid position 650, amino acid position 1 to about amino acid position 660, amino acid position 1 to about amino acid position 670, amino acid position 1 to about amino acid position 680, amino acid position 1 to about amino acid position 690, amino acid position 1 to about amino acid position 700, amino acid position 1 to about amino acid position 710, amino acid position 1 to about amino acid position 720, amino acid position 1 to about amino acid position 730, amino acid position 1 to about amino acid position 740, amino acid position 1 to about amino acid position 750, amino acid position 1 to about amino acid position 760, amino acid position 1 to about amino acid position 770, amino acid position 1 to about amino acid position 780, amino acid position 1 to about amino acid position 790, amino acid position 1 to about amino acid position 800 of a wildtype hair cell target protein (e.g., SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 20, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 41, SEQ ID NO: 43, SEQ ID NO: 45, SEQ ID NO: 48, SEQ ID NO: 51, SEQ ID NO: 53, SEQ ID NO: 55, SEQ ID NO: 57, SEQ ID NO: 59, SEQ ID NO: 61, SEQ ID NO: 64, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79).

[0236] In some examples where the number of different vectors in the composition is two, the N-terminal portion encoded by one of the two vectors can include a portion including amino acid position 1 to about amino acid position 800, about amino acid position 790, about amino acid position 780, about amino acid position 770, about amino acid position 760, about amino acid position 750, about amino acid position 740, about amino acid position 730, about amino acid position 720, about amino acid position 710, about amino acid position 700, about amino acid position 690, about amino acid position 680, about amino acid position 670, about amino acid position 660, about amino acid position 650, about amino acid position 640, about amino acid position 630, about amino acid position 620, about amino acid position 610, about amino acid position 600, about amino acid position 590, about amino acid position 580, about amino acid position 570, about amino acid position 560, about amino acid position 550, about amino acid position 540, about amino acid position 530, about amino acid position 520, about amino acid position 510, about amino acid position 500, about amino acid position 490, about amino acid position 480, about amino acid position 470, about amino acid position 460, about amino acid position 450, about amino acid position 440, about amino acid position 430, about amino acid position 420, about amino acid position 410, about amino acid position 400, about amino acid position 390, about amino acid position 380, about amino acid position 370, about amino acid position 360, about amino acid position 350, about amino acid position 340, about amino acid position 330, about amino acid position 320, about amino acid position 310, about amino acid position 300, about amino acid position 290, about amino acid position 280, about amino acid position 270, about amino acid position 260, about amino acid position 250, about amino acid position 240, about amino acid position 230, about amino acid position 220, about amino acid position 210, about amino acid position 200, about amino acid position 190, about amino acid position 180, about amino acid position 170, about amino acid position 160, about amino acid position 150, about amino acid position 140, about amino acid position 130, about amino acid position 120, about amino acid position 110, about amino acid position 100, about amino acid position 90, about amino acid position 80, about amino acid position 70, about amino acid position 60, about amino acid position 50, or about amino acid position 40 of a wildtype supporting cell target protein (e.g., SEQ ID NO: 1 or SEQ ID NO: 4).

[0237] In some examples where the number of different vectors in the composition is two, the N-terminal portion of the precursor supporting cell target protein can include a portion including amino acid position 1 to amino acid position 300, amino acid position 1 to amino acid position 310, amino acid position 1 to about amino acid position 320, amino acid position 1 to about amino acid position 330, amino acid position 1 to about amino acid position 340, amino acid position 1 to about amino acid position 350, amino acid position 1 to about amino acid position 360, amino acid position 1 to about amino acid position 370, amino acid position 1 to about amino acid position 380, amino acid position 1 to about amino acid position 390, amino acid position 1 to about amino acid position 400, amino acid position 1 to about amino acid position 410, amino acid position 1 to about amino acid position 420, amino acid position 1 to about amino acid position 430, amino acid position 1 to about amino acid position 440, amino acid position 1 to about amino acid position 450, amino acid position 1 to about amino acid position 460, amino acid position 1 to about amino acid position 470, amino acid position 1 to about amino acid position 480, amino acid position 1 to about amino acid position 490, amino acid position 1 to about amino acid position 500, amino acid position 1 to about amino acid position 510, amino acid position 1 to about amino acid position 520, amino acid position 1 to about amino acid position 530, amino acid position 1 to about amino acid position 540, amino acid position 1 to about amino acid position 550, amino acid position 1 to about amino acid position 560, amino acid position 1 to about amino acid position 570, amino acid position 1 to about amino acid position 580, amino acid position 1 to about amino acid position 590, amino acid position 1 to about amino acid position 600, amino acid position 1 to about amino acid position 610, amino acid position 1 to about amino acid position 620, amino acid position 1 to about amino acid position 630, amino acid position 1 to about amino acid position 640, amino acid position 1 to about amino acid position 650, amino acid position 1 to about amino acid position 660, amino acid position 1 to about amino acid position 670, amino acid position 1 to about amino acid position 680, amino acid position 1 to about amino acid position 690, amino acid position 1 to about amino acid position 700, amino acid position 1 to about amino acid position 710, amino acid position 1 to about amino acid position 720, amino acid position 1 to about amino acid position 730, amino acid position 1 to about amino acid position 740, amino acid position 1 to about amino acid position 750, amino acid position 1 to about amino acid position 760, amino acid position 1 to about amino acid position 770, amino acid position 1 to about amino acid position 780, amino acid position 1 to about amino acid position 790, amino acid position 1 to about amino acid position 800 of a wildtype supporting cell target protein (e.g., SEQ ID NO: 1 or SEQ ID NO: 4).

[0238] As used herein, the term “vector” means a composition including a polynucleotide capable of carrying at least one exogenous nucleic acid fragment, e.g., a plasmid vector, a transposon, a cosmid, an artificial chromosome (e.g., a human artificial chromosome (HAC), a yeast artificial chromosome (YAC), a bacterial artificial chromosome (BAC), or a P1-derived artificial chromosome (PAC)) or a viral vector (e.g., any adenoviral vectors (e.g., pSV or pCMV vectors), any retroviral vectors as described herein) and any Gateway® vectors. A vector can, e.g., include sufficient cis-acting elements for expression; other elements for expression can be supplied by the host primate cell or in an in vitro expression system. The term “vector” includes any genetic element (e.g., a plasmid, a transposon, a cosmid, an artificial chromosome, or a viral vector, etc.) that is capable of replicating when associated with the proper control elements. Thus, the term includes cloning and expression vectors, as well as viral vectors (e.g., an adeno-associated virus (AAV) vector, an adenovirus vector, a lentivirus vector, or a retrovirus vector).

[0239] Vectors include all those known in the art, including cosmids, plasmids (e.g., naked or contained in liposomes) and viruses (e.g., lentiviruses, retroviruses, adenoviruses, and adeno-associated viruses) that incorporate the recombinant polynucleotide. Skilled practitioners will be capable of selecting suitable vectors and primate cells for making any of the nucleic acids described herein.

In some embodiments the vector is a plasmid (i.e. a circular DNA molecule that can autonomously replicate inside a cell). In some embodiments, the vector can be a cosmid (e.g., pWE and sCos series (Wahl et al. (1987), Evans et al. (1989)).

[0240] In some embodiments, the vector(s) is a viral vector (e.g., adeno-associated virus, adenovirus, lentivirus, and retrovirus). Non-limiting examples of viral vectors are described herein. In some embodiments, the vector(s) is an adeno-associated viral vector (AAV) (see, e.g., Asokan et al., Mol. Ther. 20: 699-7080, 2012). “Recombinant AAV vectors” or “rAAVs” are typically composed of, at a minimum, a transgene or a portion thereof and a regulatory sequence, and optionally 5′ and 3′ AAV inverted terminal repeats (ITRs). Such a recombinant AAV vector is packaged into a capsid and delivered to a selected target cell (e.g., an outer hair cell).

[0241] The AAV sequences of the vector typically include the cis-acting 5′ and 3′ ITR sequences (See, e.g., B. J. Carter, in “Handbook of Parvoviruses”, ed., P. Tijsser, CRC Press, pp. 155 168, 1990). Typical AAV ITR sequences are about 145 nucleotides in length. In some embodiments, at least 75% of a typical ITR sequence (e.g., at least 80%, at least 85%, at least 90%, or at least 95%) is incorporated into the AAV vector. The ability to modify these ITR sequences is within the skill of the art. (See, e.g., texts such as Sambrook et al., “Molecular Cloning. A Laboratory Manual”, 2d ed., Cold Spring Harbor Laboratory, New York, 1989; and K. Fisher et al., J Virol. 70:520 532, 1996). In some embodiments, any of the coding sequences described herein are flanked by 5′ and 3′ AAV ITR sequences in the AAV vectors. The AAV ITR sequences may be obtained from any known AAV, including presently identified AAV types.

[0242] AAV vectors as described herein may include any of the regulatory elements described herein (e.g., one or more of a promoter, a polyA sequence, and an IRES).

[0243] In some embodiments, the AAV vector is selected from the group consisting of: an AAV1 vector, an AAV2 vector, an AAV3 vector, an AAV4 vector, an AAV5 vector, an AAV6 vector, an AAV7 vector, an AAV8 vector, an AAV9 vector, an AAV2.7m8 vector, an AAV8BP2 vector, and an AAV293 vector. Additional exemplary AAV vectors that can be used herein are known in the art. See, e.g., Kanaan et al., Mol. Ther. Nucleic Acids 8:184-197, 2017; Li et al., Mol. Ther. 16(7): 1252-1260; Adachi et al., Nat. Commun. 5: 3075, 2014; Isgrig et al., Nat. Commun. 10(1): 427, 2019; and Gao et al., J. Virol. 78(12): 6381-6388.

[0244] In some embodiments, the vector(s) is an adenovirus (see, e.g., Dmitriev et al. (1998) J. Virol. 72: 9706-9713; and Poulin et al., J. Virol 8: 10074-10086, 2010). In some embodiments, the vector(s) is a retrovirus (see, e.g., Maier et al. (2010) Future Microbiol 5: 1507-23).

[0245] The vectors provided herein can be of different sizes. The choice of vector that is used in any of the compositions, kits, and methods described herein may depend on the size of the vector.

[0246] In some embodiments, the vector(s) is a plasmid and can include a total length of up to about 1 kb, up to about 2 kb, up to about 3 kb, up to about 4 kb, up to about 5 kb, up to about 6 kb, up to about 7 kb, up to about 8 kb, up to about 9 kb, up to about 10 kb, up to about 11 kb, up to about 12 kb, up to about 13 kb, up to about 14 kb, or up to about 15 kb. In some embodiments, the vector(s) is a plasmid and can have a total length in a range of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 1 kb to about 9 kb, about 1 kb to about 10 kb, about 1 kb to about 11 kb, about 1 kb to about 12 kb, about 1 kb to about 13 kb, about 1 kb to about 14 kb, or about 1 kb to about 15 kb.

[0247] In some embodiments, the vector(s) is a viral vector and can have a total number of nucleotides of up to 10 kb. In some embodiments, the viral vector(s) can have a total number of nucleotides in the range of about 1 kb to about 2 kb, 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 1 kb to about 9 kb, about 1 kb to about 10 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 2 kb to about 6 kb, about 2 kb to about 7 kb, about 2 kb to about 8 kb, about 2 kb to about 9 kb, about 2 kb to about 10 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, about 3 kb to about 6 kb, about 3 kb to about 7 kb, about 3 kb to about 8 kb, about 3 kb to about 9 kb, about 3 kb to about 10 kb, about 4 kb to about 5 kb, about 4 kb to about 6 kb, about 4 kb to about 7 kb, about 4 kb to about 8 kb, about 4 kb to about 9 kb, about 4 kb to about 10 kb, about 5 kb to about 6 kb, about 5 kb to about 7 kb, about 5 kb to about 8 kb, about 5 kb to about 9 kb, about 5 kb to about 10 kb, about 6 kb to about 7 kb, about 6 kb to about 8 kb, about 6 kb to about 9 kb, about 6 kb to about 10 kb, about 7 kb to about 8 kb, about 7 kb to about 9 kb, about 7 kb to about 10 kb, about 8 kb to about 9 kb, about 8 kb to about 10 kb, or about 9 kb to about 10 kb.

[0248] In some embodiments, the vector(s) is a lentivirus and can have a total number of nucleotides of up to 8 kb. In some examples, the lentivirus(es) can have a total number of nucleotides of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 2 kb to about 6 kb, about 2 kb to about 7 kb, about 2 kb to about 8 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, about 3 kb to about 6 kb, about 3 kb to about 7 kb, about 3 kb to about 8 kb, about 4 kb to about 5 kb, about 4 kb to about 6 kb, about 4 kb to about 7 kb, about 4 kb to about 8 kb, about 5 kb to about 6 kb, about 5 kb to about 7 kb, about 5 kb to about 8 kb, about 6 kb to about 8 kb, about 6 kb to about 7 kb, or about 7 kb to about 8 kb.

[0249] In some embodiments, the vector(s) is an adenovirus and can have a total number of nucleotides of up to 8 kb. In some embodiments, the adenovirus(es) can have a total number of nucleotides in the range of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 2 kb to about 6 kb, about 2 kb to about 7 kb, about 2 kb to about 8 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, about 3 kb to about 6 kb, about 3 kb to about 7 kb, about 3 kb to about 8 kb, about 4 kb to about 5 kb, about 4 kb to about 6 kb, about 4 kb to about 7 kb, about 4 kb to about 8 kb, about 5 kb to about 6 kb, about 5 kb to about 7 kb, about 5 kb to about 8 kb, about 6 kb to about 7 kh, about 6 kb to about 8 kb, or about 7 kb to about 8 kb.

[0250] In some embodiments, the vector(s) is an adeno-associated virus (AAV vector) and can include a total number of nucleotides of up to 5 kb. In some embodiments, the AAV vector(s) can include a total number of nucleotides in the range of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, or about 4 kb to about 5 kb.

[0251] In some embodiments of any of the compositions, kits, and methods provided herein, the at least two different vectors can be substantially the same type of vector and may differ in size. In some embodiments, the at least two different vectors can be different types of vector, and may have substantially the same size or have different sizes.

[0252] In some embodiments, any of the at least two vectors can have a total number of nucleotides in the range of about 500 nucleotides to about 10,000 nucleotides, about 500 nucleotides to about 9,500 nucleotides, about 500 nucleotides to about 9,000 nucleotides, about 500 nucleotides to about 8,500 nucleotides, about 500 nucleotides to about 8,000 nucleotides, about 500 nucleotides to about 7,800 nucleotides, about 500 nucleotides to about 7,600 nucleotides, about 500 nucleotides to about 7,400 nucleotides, about 500 nucleotides to about 7,200 nucleotides, about 500 nucleotides to about 7,000 nucleotides, about 500 nucleotides to about 6,800 nucleotides, about 500 nucleotides to about 6,600 nucleotides, about 500 nucleotides to about 6,400 nucleotides, about 500 nucleotides to about 6,200 nucleotides, about 500 nucleotides to about 6,000 nucleotides, about 500 nucleotides to about 5,800 nucleotides, about 500 nucleotides to about 5,600 nucleotides, about 500 nucleotides to about 5,400 nucleotides, about 500 nucleotides to about 5,200 nucleotides, about 500 nucleotides to about 5,000 nucleotides, about 500 nucleotides to about 4,800 nucleotides, about 4,600 nucleotides, about 500 nucleotides to about 4,400 nucleotides, about 500 nucleotides to about 4,200 nucleotides, about 500 nucleotides to about 4,000 nucleotides, about 500 nucleotides to about 3,800 nucleotides, about 500 nucleotides to about 3,600 nucleotides, about 500 nucleotides to about 3,400 nucleotides, about 500 nucleotides to about 3,200 nucleotides, about 500 nucleotides to about 3,000 nucleotides, about 500 nucleotides to about 2,800 nucleotides, about 500 nucleotides to about 2,600 nucleotides, about 500 nucleotides to about 2,400 nucleotides, about 500 nucleotides to about 2,200 nucleotides, about 500 nucleotides to about 2,000 nucleotides, about 500 nucleotides to about 1,800 nucleotides, about 500 nucleotides to about 1,600 nucleotides, about 500 nucleotides to about 1,400 nucleotides, about 500 nucleotides to about 1,200 nucleotides, about 500 nucleotides to about 1,000 nucleotides, about 500 nucleotides to about 800 nucleotides, about 800 nucleotides to about 10,000 nucleotides, about 800 nucleotides to about 9,500 nucleotides, about 800 nucleotides to about 9,000 nucleotides, about 800 nucleotides to about 8,500 nucleotides, about 800 nucleotides to about 8,000 nucleotides, about 800 nucleotides to about 7,800 nucleotides, about 800 nucleotides to about 7,600 nucleotides, about 800 nucleotides to about 7,400 nucleotides, about 800 nucleotides to about 7,200 nucleotides, about 800 nucleotides to about 7,000 nucleotides, about 800 nucleotides to about 6,800 nucleotides, about 800 nucleotides to about 6,600 nucleotides, about 800 nucleotides to about 6,400 nucleotides, about 800 nucleotides to about 6,200 nucleotides, about 800 nucleotides to about 6,000 nucleotides, about 800 nucleotides to about 5,800 nucleotides, about 800 nucleotides to about 5,600 nucleotides, about 800 nucleotides to about 5,400 nucleotides, about 800 nucleotides to about 5,200 nucleotides, about 800 nucleotides to about 5,000 nucleotides, about 800 nucleotides to about 4,800 nucleotides, about 800 nucleotides to about 4,600 nucleotides, about 800 nucleotides to about 4,400 nucleotides, about 800 nucleotides to about 4,200 nucleotides, about 800 nucleotides to about 4,000 nucleotides, about 800 nucleotides to about 3,800 nucleotides, about 800 nucleotides to about 3,600 nucleotides, about 800 nucleotides to about 3,400 nucleotides, about 800 nucleotides to about 3,200 nucleotides, about 800 nucleotides to about 3,000 nucleotides, about 800 nucleotides to about 2,800 nucleotides, about 800 nucleotides to about 2,600 nucleotides, about 800 nucleotides to about 2,400 nucleotides, about 800 nucleotides to about 2,200 nucleotides, about 800 nucleotides to about 2,000 nucleotides, about 800 nucleotides to about 1,800 nucleotides, about 800 nucleotides to about 1,600 nucleotides, about 800 nucleotides to about 1,400 nucleotides, about 800 nucleotides to about 1,200 nucleotides, about 800 nucleotides to about 1,000 nucleotides, about 1,000 nucleotides to about 10,000 nucleotides, about 1,000 nucleotides to about 9,000 nucleotides, about 1,000 nucleotides to about 8,500 nucleotides, about 1,000 nucleotides to about 8,000 nucleotides, about 1,000 nucleotides to about 7,800 nucleotides, about 1,000 nucleotides to about 7,600 nucleotides, about 1,000 nucleotides to about 7,400 nucleotides, about 1,000 nucleotides to about 7,200 nucleotides, about 1,000 nucleotides to about 7,000 nucleotides, about 1,000 nucleotides to about 6,800 nucleotides, about 1,000 nucleotides to about 6,600 nucleotides, about 1,000 nucleotides to about 6,400 nucleotides, about 1,000 nucleotides to about 6,200 nucleotides, about 1,000 nucleotides to about 6,000 nucleotides, about 1,000 nucleotides to about 5,800 nucleotides, about 1,000 nucleotides to about 5,600 nucleotides, about 1,000 nucleotides to about 5,400 nucleotides, about 1,000 nucleotides to about 5,200 nucleotides, about 1,000 nucleotides to about 5,000 nucleotides, about 1,000 nucleotides to about 4,800 nucleotides, about 1,000 nucleotides to about 4,600 nucleotides, about 1,000 nucleotides to about 4,400 nucleotides, about 1,000 nucleotides to about 4,200 nucleotides, about 1,000 nucleotides to about 4,000 nucleotides, about 1,000 nucleotides to about 3,800 nucleotides, about 1,000 nucleotides to about 3,600 nucleotides, about 1,000 nucleotides to about 3,400 nucleotides, about 1,000 nucleotides to about 3,200 nucleotides, about 1,000 nucleotides to about 3,000 nucleotides, about 1,000 nucleotides to about 2,600 nucleotides, about 1,000 nucleotides to about 2,400 nucleotides, about 1,000 nucleotides to about 2,200 nucleotides, about 1,000 nucleotides to about 2,000 nucleotides, about 1,000 nucleotides to about 1,800 nucleotides, about 1,000 nucleotides to about 1,600 nucleotides, about 1,000 nucleotides to about 1,400 nucleotides, about 1,000 nucleotides to about 1,200 nucleotides, about 1,200 nucleotides to about 10,000 nucleotides, about 1,200 nucleotides to about 9,500 nucleotides, about 1,200 nucleotides to about 9,000 nucleotides, about 1,200 nucleotides to about 8,500 nucleotides, about 1,200 nucleotides to about 8,000 nucleotides, about 1,200 nucleotides to about 7,800 nucleotides, about 1,200 nucleotides to about 7,600 nucleotides, about 1,200 nucleotides to about 7,400 nucleotides, about 1,200 nucleotides to about 7,200 nucleotides, about 1,200 nucleotides to about 7,000 nucleotides, about 1,200 nucleotides to about 6,800 nucleotides, about 1,200 nucleotides to about 6,600 nucleotides, about 1,200 nucleotides to about 6,400 nucleotides, about 1,200 nucleotides to about 6,200 nucleotides, about 1,200 nucleotides to about 6,000 nucleotides, about 1,200 nucleotides to about 5,800 nucleotides, about 1,200 nucleotides to about 5,600 nucleotides, about 1,200 nucleotides to about 5,400 nucleotides, about 1,200 nucleotides to about 5,000 nucleotides, about 1,200 nucleotides to about 4,800 nucleotides, about 1,200 nucleotides to about 4,600 nucleotides, about 1,200 nucleotides to about 4,400 nucleotides, about 1,200 nucleotides to about 4,200 nucleotides, about 1,200 nucleotides to about 4,000 nucleotides, about 1,200 nucleotides to about 3,800 nucleotides, about 1,200 nucleotides to about 3,600 nucleotides, about 1,200 nucleotides to about 3,400 nucleotides, about 1,200 nucleotides to about 3,200 nucleotides, about 1,200 nucleotides to about 3,000 nucleotides, about 1,200 nucleotides to about 2,800 nucleotides, about 1,200 nucleotides to about 2,600 nucleotides, about 1,200 nucleotides to about 2,400 nucleotides, about 1,200 nucleotides to about 2,200 nucleotides, about 1,200 nucleotides to about 2,000 nucleotides, about 1,200 nucleotides to about 1,800 nucleotides, about 1,200 nucleotides to about 1,600 nucleotides, about 1,200 nucleotides to about 1,400 nucleotides, about 1,400 nucleotides to about 10,000 nucleotides, about 1,400 nucleotides to about 9,500 nucleotides, about 1,400 nucleotides to about 9,000 nucleotides, about 1,400 nucleotides to about 8,500 nucleotides, about 1,400 nucleotides to about 8,000 nucleotides, about 1,400 nucleotides to about 7,800 nucleotides, about 1,400 nucleotides to about 7,600 nucleotides, about 1,400 nucleotides to about 7,400 nucleotides, about 1,400 nucleotides to about 7,200 nucleotides, about 1,400 nucleotides to about 7,000 nucleotides, about 1,400 nucleotides to about 6,800 nucleotides, about 1,400 nucleotides to about 6,600 nucleotides, about 1,400 nucleotides to about 6,400 nucleotides, about 1,400 nucleotides to about 6,200 nucleotides, about 1,400 nucleotides to about 6,000 nucleotides, about 1,400 nucleotides to about 5,800 nucleotides, about 1,400 nucleotides to about 5,600 nucleotides, about 1,400 nucleotides to about 5,400 nucleotides, about 1,400 nucleotides to about 5,200 nucleotides, about 1,400 nucleotides to about 5,000 nucleotides, about 1,400 nucleotides to about 4,800 nucleotides, about 1,400 nucleotides to about 4,600 nucleotides, about 1,400 nucleotides to about 4,400 nucleotides, about 1,400 nucleotides to about 4,200 nucleotides, about 1,400 nucleotides to about 4,000 nucleotides, about 1,400 nucleotides to about 3,800 nucleotides, about 1,400 nucleotides to about 3,600 nucleotides, about 1,400 nucleotides to about 3,400 nucleotides, about 1,400 nucleotides to about 3,200 nucleotides, about 1,400 nucleotides to about 3,000 nucleotides, about 1,400 nucleotides to about 2,600 nucleotides, about 1,400 nucleotides to about 2,400 nucleotides, about 1,400 nucleotides to about 2,200 nucleotides, about 1,400 nucleotides to about 2,000 nucleotides, about 1,400 nucleotides to about 1,800 nucleotides, about 1,400 nucleotides to about 1,600 nucleotides, about 1,600 nucleotides to about 10,000 nucleotides, about 1,600 nucleotides to about 9,500 nucleotides, about 1,600 nucleotides to about 9,000 nucleotides, about 1,600 nucleotides to about 8,500 nucleotides, about 1,600 nucleotides to about 8,000 nucleotides, about 1,600 nucleotides to about 7,800 nucleotides, about 1,600 nucleotides to about 7,600 nucleotides, about 1,600 nucleotides to about 7,400 nucleotides, about 1,600 nucleotides to about 7,200 nucleotides, about 1,600 nucleotides to about 7,000 nucleotides, about 1,600 nucleotides to about 6,800 nucleotides, about 1,600 nucleotides to about 6,400 nucleotides, about 1,600 nucleotides to about 6,200 nucleotides, about 1,600 nucleotides to about 6,000 nucleotides, about 1,600 nucleotides to about 5,800 nucleotides, about 1,600 nucleotides to about 5,600 nucleotides, about 1,600 nucleotides to about 5,400 nucleotides, about 1,600 nucleotides to about 5,200 nucleotides, about 1,600 nucleotides to about 5,000 nucleotides, about 1,600 nucleotides to about 4,800 nucleotides, about 1,600 nucleotides to about 4,600 nucleotides, about 1,600 nucleotides to about 4,400 nucleotides, about 1,600 nucleotides to about 4,200 nucleotides, about 1,600 nucleotides to about 4,000 nucleotides, about 1,600 nucleotides to about 3,800 nucleotides, about 1,600 nucleotides to about 3,600 nucleotides, about 1,600 nucleotides to about 3,400 nucleotides, about 1,600 nucleotides to about 3,200 nucleotides, about 1,600 nucleotides to about 3,000 nucleotides, about 1,600 nucleotides to about 2,800 nucleotides, about 1,600 nucleotides to about 2,600 nucleotides, about 1,600 nucleotides to about 2,400 nucleotides, about 1,600 nucleotides to about 2,200 nucleotides, about 1,600 nucleotides to about 2,000 nucleotides, about 1,600 nucleotides to about 1,800 nucleotides, about 1,800 nucleotides to about 10,000 nucleotides, about 1,800 nucleotides to about 9,500 nucleotides, about 1,800 nucleotides to about 9,000 nucleotides, about 1,800 nucleotides to about 8,500 nucleotides, about 1,800 nucleotides to about 8,000 nucleotides, about 1,800 nucleotides to about 7,800 nucleotides, about 1,800 nucleotides to about 7,600 nucleotides, about 1,800 nucleotides to about 7,400 nucleotides, about 1,800 nucleotides to about 7,200 nucleotides, about 1,800 nucleotides to about 7,000 nucleotides, about 1,800 nucleotides to about 6,800 nucleotides, about 1,800 nucleotides to about 6,600 nucleotides, about 1,800 nucleotides to about 6,400 nucleotides, about 1,800 nucleotides to about 6,200 nucleotides, about 1,800 nucleotides to about 6,000 nucleotides, about 1,800 nucleotides to about 5,800 nucleotides, about 1,800 nucleotides to about 5,600 nucleotides, about 1,800 nucleotides to about 5,400 nucleotides, about 1,800 nucleotides to about 5,200 nucleotides, about 1,800 nucleotides to about 5,000 nucleotides, about 1,800 nucleotides to about 4,800 nucleotides, about 1,800 nucleotides to about 4,600 nucleotides, about 1,800 nucleotides to about 4,400 nucleotides, about 1,800 nucleotides to about 4,200 nucleotides, about 1,800 nucleotides to about 4,000 nucleotides, about 1,800 nucleotides to about 3,800 nucleotides, about 1,800 nucleotides to about 3,600 nucleotides, about 1,800 nucleotides to about 3,400 nucleotides, about 1,800 nucleotides to about 3,200 nucleotides, about 1,800 nucleotides to about 3,000 nucleotides, about 1,800 nucleotides to about 2,800 nucleotides, about 1,800 nucleotides to about 2,600 nucleotides, about 1,800 nucleotides to about 2,400 nucleotides, about 1,800 nucleotides to about 2,200 nucleotides, about 1,800 nucleotides to about 2,000 nucleotides, about 2,000 nucleotides to about 10,000 nucleotides, about 2,000 nucleotides to about 9,500 nucleotides, about 2,000 nucleotides to about 9,000 nucleotides, about 2,000 nucleotides to about 8,500 nucleotides, about 2,000 nucleotides to about 8,000 nucleotides, about 2,000 nucleotides to about 7,800 nucleotides, about 2,000 nucleotides to about 7,600 nucleotides, about 2,000 nucleotides to about 7,400 nucleotides, about 2,000 nucleotides to about 7,200 nucleotides, about 2,000 nucleotides to about 7,000 nucleotides, about 2,000 nucleotides to about 6,800 nucleotides, about 2,000 nucleotides to about 6,600 nucleotides, about 2,000 nucleotides to about 6,400 nucleotides, about 2,000 nucleotides to about 6,200 nucleotides, about 2,000 nucleotides to about 6,000 nucleotides, about 2,000 nucleotides to about 5,800 nucleotides, about 2,000 nucleotides to about 5,600 nucleotides, about 2,000 nucleotides to about 5,400 nucleotides, about 2,000 nucleotides to about 5,200 nucleotides, about 2,000 nucleotides to about 5,000 nucleotides, about 2,000 nucleotides to about 4,800 nucleotides, about 2,000 nucleotides to about 4,600 nucleotides, about 2,000 nucleotides to about 4,400 nucleotides, about 2,000 nucleotides to about 4,200 nucleotides, about 2,000 nucleotides to about 4,000 nucleotides, about 2,000 nucleotides to about 3,800 nucleotides, about 2,000 nucleotides to about 3,600 nucleotides, about 2,000 nucleotides to about 3,400 nucleotides, about 2,000 nucleotides to about 3,200 nucleotides, about 2,000 nucleotides to about 3,000 nucleotides, about 2,000 nucleotides to about 2,800 nucleotides, about 2,000 nucleotides to about 2,600 nucleotides, about 2,000 nucleotides to about 2,400 nucleotides, about 2,000 nucleotides to about 2,200 nucleotides, about 2,200 nucleotides to about 10,000 nucleotides, about 9,500 nucleotides, about 9,000 nucleotides, about 8,500 nucleotides, about 8,000 nucleotides, about 7,800 nucleotides, about 7,600 nucleotides, about 7,400 nucleotides, about 7,200 nucleotides, about 7,000 nucleotides, about 6,800 nucleotides, about 6,600 nucleotides, about 6,400 nucleotides, about 6,200 nucleotides, about 6,000 nucleotides, about 5,800 nucleotides, about 5,600 nucleotides, about 5,400 nucleotides, about 5,200 nucleotides, about 5,000 nucleotides, about 4,800 nucleotides, about 4,600 nucleotides, about 4,400 nucleotides, about 4,200 nucleotides, about 4,000 nucleotides, about 3,800 nucleotides, about 3,600 nucleotides, about 3,400 nucleotides, about 3,200 nucleotides, about 3,000 nucleotides, about 2,800 nucleotides, about 2,600 nucleotides, about 2,400 nucleotides, about 2,400 nucleotides to about 10,000 nucleotides, about 2,400 nucleotides to about 9,500 nucleotides, about 2,400 nucleotides to about 9,000 nucleotides, about 2,400 nucleotides to about 8,500 nucleotides, about 2,400 nucleotides to about 8,000 nucleotides, about 2,400 nucleotides to about 7,800 nucleotides, about 2,400 nucleotides to about 7,600 nucleotides, about 2,400 nucleotides to about 7,400 nucleotides, about 2,400 nucleotides to about 7,200 nucleotides, about 2,400 nucleotides to about 7,000 nucleotides, about 2,400 nucleotides to about 6,800 nucleotides, about 2,400 nucleotides to about 6,600 nucleotides, about 2,400 nucleotides to about 6,400 nucleotides, about 2,400 nucleotides to about 6,200 nucleotides, about 2,400 nucleotides to about 6,000 nucleotides, about 2,400 nucleotides to about 5,800 nucleotides, about 2,400 nucleotides to about 5,600 nucleotides, about 2,400 nucleotides to about 5,400 nucleotides, about 2,400 nucleotides to about 5,200 nucleotides, about 2,400 nucleotides to about 5,000 nucleotides, about 2,400 nucleotides to about 4,800 nucleotides, about 2,400 nucleotides to about 4,600 nucleotides, about 2,400 nucleotides to about 4,400 nucleotides, about 2,400 nucleotides to about 4,200 nucleotides, about 2,400 nucleotides to about 4,000 nucleotides, about 2,400 nucleotides to about 3,800 nucleotides, about 2,400 nucleotides to about 3,600 nucleotides, about 2,400 nucleotides to about 3,400 nucleotides, about 2,400 nucleotides to about 3,200 nucleotides, about 2,400 nucleotides to about 3,000 nucleotides, about 2,400 nucleotides to about 2,800 nucleotides, about 2,400 nucleotides to about 2,600 nucleotides, about 2,600 nucleotides to about 10,000 nucleotides, about 2,600 nucleotides to about 9,500 nucleotides, about 2,600 nucleotides to about 9,000 nucleotides, about 2,600 nucleotides to about 8,500 nucleotides, about 2,600 nucleotides to about 8,000 nucleotides, about 2,600 nucleotides to about 7,800 nucleotides, about 2,600 nucleotides to about 7,600 nucleotides, about 2,600 nucleotides to about 7,400 nucleotides, about 2,600 nucleotides to about 7,200 nucleotides, about 2,600 nucleotides to about 7,000 nucleotides, about 2,600 nucleotides to about 6,800 nucleotides, about 2,600 nucleotides to about 6,600 nucleotides, about 2,600 nucleotides to about 6,400 nucleotides, about 2,600 nucleotides to about 6,200 nucleotides, about 2,600 nucleotides to about 6,000 nucleotides, about 2,600 nucleotides to about 5,800 nucleotides, about 2,600 nucleotides to about 5,600 nucleotides, about 2,600 nucleotides to about 5,400 nucleotides, about 2,600 nucleotides to about 5,200 nucleotides, about 2,600 nucleotides to about 5,000 nucleotides, about 2,600 nucleotides to about 4,800 nucleotides, about 2,600 nucleotides to about 4,600 nucleotides, about 2,600 nucleotides to about 4,400 nucleotides, about 2,600 nucleotides to about 4,200 nucleotides, about 2,600 nucleotides to about 4,000 nucleotides, about 2,600 nucleotides to about 3,800 nucleotides, about 2,600 nucleotides to about 3,600 nucleotides, about 2,600 nucleotides to about 3,400 nucleotides, about 2,600 nucleotides to about 3,200 nucleotides, about 2,600 nucleotides to about 3,000 nucleotides, about 2,600 nucleotides to about 2,800 nucleotides, about 2,800 nucleotides to about 10,000 nucleotides, about 2,800 nucleotides to about 9,500 nucleotides, about 2,800 nucleotides to about 9,000 nucleotides, about 2,800 nucleotides to about 8,500 nucleotides, about 2,800 nucleotides to about 8,000 nucleotides, about 2,800 nucleotides to about 7,800 nucleotides, about 2,800 nucleotides to about 7,600 nucleotides, about 2,800 nucleotides to about 7,400 nucleotides, about 2,800 nucleotides to about 7,200 nucleotides, about 2,800 nucleotides to about 7,000 nucleotides, about 2,800 nucleotides to about 6,800 nucleotides, about 2,800 nucleotides to about 6,600 nucleotides, about 2,800 nucleotides to about 6,400 nucleotides, about 2,800 nucleotides to about 6,200 nucleotides, about 2,800 nucleotides to about 6,000 nucleotides, about 2,800 nucleotides to about 5,800 nucleotides, about 2,800 nucleotides to about 5,600 nucleotides, about 2,800 nucleotides to about 5,400 nucleotides, about 2,800 nucleotides to about 5,200 nucleotides, about 2,800 nucleotides to about 5,000 nucleotides, about 2,800 nucleotides to about 4,800 nucleotides, about 2,800 nucleotides to about 4,600 nucleotides, about 2,800 nucleotides to about 4,400 nucleotides, about 2,800 nucleotides to about 4,200 nucleotides, about 2,800 nucleotides to about 4,000 nucleotides, about 2,800 nucleotides to about 3,800 nucleotides, about 2,800 nucleotides to about 3,600 nucleotides, about 2,800 nucleotides to about 3,400 nucleotides, about 2,800 nucleotides to about 3,200 nucleotides, about 2,800 nucleotides to about 3,000 nucleotides, about 3,000 nucleotides to about 10,000 nucleotides, about 3,000 nucleotides to about 9,500 nucleotides, about 3,000 nucleotides to about 9,000 nucleotides, about 3,000 nucleotides to about 8,500 nucleotides, about 3,000 nucleotides to about 8,000 nucleotides, about 3,000 nucleotides to about 7,800 nucleotides, about 3,000 nucleotides to about 7,600 nucleotides, about 3,000 nucleotides to about 7,400 nucleotides, about 3,000 nucleotides to about 7,200 nucleotides, about 3,000 nucleotides to about 7,000 nucleotides, about 3,000 nucleotides to about 6,800 nucleotides, about 3,000 nucleotides to about 6,600 nucleotides, about 3,000 nucleotides to about 6,400 nucleotides, about 3,000 nucleotides to about 6,200 nucleotides, about 3,000 nucleotides to about 6,000 nucleotides, about 3,000 nucleotides to about 5,800 nucleotides, about 3,000 nucleotides to about 5,600 nucleotides, about 3,000 nucleotides to about 5,400 nucleotides, about 3,000 nucleotides to about 5,200 nucleotides, about 3,000 nucleotides to about 5,000 nucleotides, about 3,000 nucleotides to about 4,800 nucleotides, about 3,000 nucleotides to about 4,600 nucleotides, about 3,000 nucleotides to about 4,400 nucleotides, about 3,000 nucleotides to about 4,200 nucleotides, about 3,000 nucleotides to about 4,000 nucleotides, about 3,000 nucleotides to about 3,800 nucleotides, about 3,000 nucleotides to about 3,600 nucleotides, about 3,000 nucleotides to about 3,400 nucleotides, about 3,000 nucleotides to about 3,200 nucleotides, about 3,200 nucleotides to about 10,000 nucleotides, about 3,200 nucleotides to about 9,500 nucleotides, about 3,200 nucleotides to about 9,000 nucleotides, about 3,200 nucleotides to about 8,500 nucleotides, about 3,200 nucleotides to about 8,000 nucleotides, about 3,200 nucleotides to about 7,800 nucleotides, about 3,200 nucleotides to about 7,600 nucleotides, about 3,200 nucleotides to about 7,400 nucleotides, about 3,200 nucleotides to about 7,200 nucleotides, about 3,200 nucleotides to about 7,000 nucleotides, about 3,200 nucleotides to about 6,800 nucleotides, about 3,200 nucleotides to about 6,600 nucleotides, about 3,200 nucleotides to about 6,400 nucleotides, about 3,200 nucleotides to about 6,200 nucleotides, about 3,200 nucleotides to about 6,000 nucleotides, about 3,200 nucleotides to about 5,800 nucleotides, about 3,200 nucleotides to about 5,600 nucleotides, about 3,200 nucleotides to about 5,400 nucleotides, about 3,200 nucleotides to about 5,200 nucleotides, about 3,200 nucleotides to about 5,000 nucleotides, about 3,200 nucleotides to about 4,800 nucleotides, about 3,200 nucleotides to about 4,600 nucleotides, about 3,200 nucleotides to about 4,400 nucleotides, about 3,200 nucleotides to about 4,200 nucleotides, about 3,200 nucleotides to about 4,000 nucleotides, about 3,200 nucleotides to about 3,800 nucleotides, about 3,200 nucleotides to about 3,600 nucleotides, about 3,200 nucleotides to about 3,400 nucleotides, about 3,400 nucleotides to about 10,000 nucleotides, about 3,400 nucleotides to about 9,500 nucleotides, about 3,400 nucleotides to about 9,000 nucleotides, about 3,400 nucleotides to about 8,500 nucleotides, about 3,400 nucleotides to about 8,000 nucleotides, about 3,400 nucleotides to about 7,800 nucleotides, about 3,400 nucleotides to about 7,600 nucleotides, about 3,400 nucleotides to about 7,400 nucleotides, about 3,400 nucleotides to about 7,200 nucleotides, about 3,400 nucleotides to about 7,000 nucleotides, about 3,400 nucleotides to about 6,800 nucleotides, about 3,400 nucleotides to about 6,600 nucleotides, about 3,400 nucleotides to about 6,400 nucleotides, about 3,400 nucleotides to about 6,200 nucleotides, about 3,400 nucleotides to about 6,000 nucleotides, about 3,400 nucleotides to about 5,800 nucleotides, about 3,400 nucleotides to about 5,600 nucleotides, about 3,400 nucleotides to about 5,400 nucleotides, about 3,400 nucleotides to about 5,200 nucleotides, about 3,400 nucleotides to about 5,000 nucleotides, about 3,400 nucleotides to about 4,800 nucleotides, about 3,400 nucleotides to about 4,600 nucleotides, about 3,400 nucleotides to about 4,400 nucleotides, about 3,400 nucleotides to about 4,200 nucleotides, about 3,400 nucleotides to about 4,000 nucleotides, about 3,400 nucleotides to about 3,800 nucleotides, about 3,400 nucleotides to about 3,600 nucleotides, about 3,600 nucleotides to about 10,000 nucleotides, about 3,600 nucleotides to about 9,500 nucleotides, about 3,600 nucleotides to about 9,000 nucleotides, about 3,600 nucleotides to about 8,500 nucleotides, about 3,600 nucleotides to about 8,000 nucleotides, about 3,600 nucleotides to about 7,800 nucleotides, about 3,600 nucleotides to about 7,600 nucleotides, about 3,600 nucleotides to about 7,400 nucleotides, about 3,600 nucleotides to about 7,200 nucleotides, about 3,600 nucleotides to about 7,000 nucleotides, about 3,600 nucleotides to about 6,800 nucleotides, about 3,600 nucleotides to about 6,600 nucleotides, about 3,600 nucleotides to about 6,400 nucleotides, about 3,600 nucleotides to about 6,200 nucleotides, about 3,600 nucleotides to about 6,000 nucleotides, about 3,600 nucleotides to about 5,800 nucleotides, about 3,600 nucleotides to about 5,600 nucleotides, about 3,600 nucleotides to about 5,400 nucleotides, about 3,600 nucleotides to about 5,200 nucleotides, about 3,600 nucleotides to about 5,000 nucleotides, about 3,600 nucleotides to about 4,800 nucleotides, about 3,600 nucleotides to about 4,600 nucleotides, about 3,600 nucleotides to about 4,400 nucleotides, about 3,600 nucleotides to about 4,200 nucleotides, about 3,600 nucleotides to about 4,000 nucleotides, about 3,600 nucleotides to about 3,800 nucleotides, about 3,800 nucleotides to about 10,000 nucleotides, about 3,800 nucleotides to about 9,500 nucleotides, about 3,800 nucleotides to about 9,000 nucleotides, about 3,800 nucleotides to about 8,500 nucleotides, about 3,800 nucleotides to about 8,000 nucleotides, about 3,800 nucleotides to about 7,800 nucleotides, about 3,800 nucleotides to about 7,600 nucleotides, about 3,800 nucleotides to about 7,400 nucleotides, about 3,800 nucleotides to about 7,200 nucleotides, about 3,800 nucleotides to about 7,000 nucleotides, about 3,800 nucleotides to about 6,800 nucleotides, about 3,800 nucleotides to about 6,600 nucleotides, about 3,800 nucleotides to about 6,400 nucleotides, about 3,800 nucleotides to about 6,200 nucleotides, about 3,800 nucleotides to about 6,000 nucleotides, about 3,800 nucleotides to about 5,800 nucleotides, about 3,800 nucleotides to about 5,600 nucleotides, about 3,800 nucleotides to about 5,400 nucleotides, about 3,800 nucleotides to about 5,200 nucleotides, about 3,800 nucleotides to about 5,000 nucleotides, about 3,800 nucleotides to about 4,800 nucleotides, about 3,800 nucleotides to about 4,600 nucleotides, about 3,800 nucleotides to about 4,200 nucleotides, about 3,800 nucleotides to about 4,000 nucleotides, about 4,000 nucleotides to about 10,000 nucleotides, about 4,000 nucleotides to about 9,500 nucleotides, about 4,000 nucleotides to about 9,000 nucleotides, about 4,000 nucleotides to about 8,500 nucleotides, about 4,000 nucleotides to about 8,000 nucleotides, about 4,000 nucleotides to about 7,800 nucleotides, about 4,000 nucleotides to about 7,600 nucleotides, about 4,000 nucleotides to about 7,400 nucleotides, about 4,000 nucleotides to about 7,200 nucleotides, about 4,000 nucleotides to about 7,000 nucleotides, about 4,000 nucleotides to about 6,800 nucleotides, about 4,000 nucleotides to about 6,600 nucleotides, about 4,000 nucleotides to about 6,400 nucleotides, about 4,000 nucleotides to about 6,200 nucleotides, about 4,000 nucleotides to about 6,000 nucleotides, about 4,000 nucleotides to about 5,800 nucleotides, about 4,000 nucleotides to about 5,600 nucleotides, about 4,000 nucleotides to about 5,400 nucleotides, about 4,000 nucleotides to about 5,200 nucleotides, about 4,000 nucleotides to about 5,000 nucleotides, about 4,000 nucleotides to about 4,800 nucleotides, about 4,000 nucleotides to about 4,600 nucleotides, about 4,000 nucleotides to about 4,400 nucleotides, about 4,000 nucleotides to about 4,200 nucleotides, about 4,200 nucleotides to about 10,000 nucleotides, about 4,200 nucleotides to about 9,500 nucleotides, about 4,200 nucleotides to about 9,000 nucleotides, about 4,200 nucleotides to about 8,500 nucleotides, about 4,200 nucleotides to about 8,000 nucleotides, about 4,200 nucleotides to about 7,800 nucleotides, about 4,200 nucleotides to about 7,600 nucleotides, about 4,200 nucleotides to about 7,400 nucleotides, about 4,200 nucleotides to about 7,200 nucleotides, about 4,200 nucleotides to about 7,000 nucleotides, about 4,200 nucleotides to about 6,800 nucleotides, about 4,200 nucleotides to about 6,600 nucleotides, about 4,200 nucleotides to about 6,400 nucleotides, about 4,200 nucleotides to about 6,200 nucleotides, about 4,200 nucleotides to about 6,000 nucleotides, about 4,200 nucleotides to about 5,800 nucleotides, about 4,200 nucleotides to about 5,600 nucleotides, about 4,200 nucleotides to about 5,400 nucleotides, about 4,200 nucleotides to about 5,200 nucleotides, about 4,200 nucleotides to about 5,000 nucleotides, about 4,200 nucleotides to about 4,800 nucleotides, about 4,200 nucleotides to about 4,600 nucleotides, about 4,200 nucleotides to about 4,400 nucleotides, about 4,400 nucleotides to about 10,000 nucleotides, about 4,400 nucleotides to about 9,500 nucleotides, about 4,400 nucleotides to about 9,000 nucleotides, about 4,400 nucleotides to about 8,500 nucleotides, about 4,400 nucleotides to about 8,000 nucleotides, about 4,400 nucleotides to about 7,800 nucleotides, about 4,400 nucleotides to about 7,600 nucleotides, about 4,400 nucleotides to about 7,400 nucleotides, about 4,400 nucleotides to about 7,200 nucleotides, about 4,400 nucleotides to about 7,000 nucleotides, about 4,400 nucleotides to about 6,800 nucleotides, about 4,400 nucleotides to about 6,600 nucleotides, about 4,400 nucleotides to about 6,400 nucleotides, about 4,400 nucleotides to about 6,200 nucleotides, about 4,400 nucleotides to about 6,000 nucleotides, about 4,400 nucleotides to about 5,800 nucleotides, about 4,400 nucleotides to about 5,600 nucleotides, about 4,400 nucleotides to about 5,400 nucleotides, about 4,400 nucleotides to about 5,200 nucleotides, about 4,400 nucleotides to about 5,000 nucleotides, about 4,400 nucleotides to about 4,800 nucleotides, about 4,400 nucleotides to about 4,600 nucleotides, about 4,600 nucleotides to about 10,000 nucleotides, about 4,600 nucleotides to about 9,500 nucleotides, about 4,600 nucleotides to about 9,000 nucleotides, about 4,600 nucleotides to about 8,500 nucleotides, about 4,600 nucleotides to about 8,000 nucleotides, about 4,600 nucleotides to about 7,800 nucleotides, about 4,600 nucleotides to about 7,600 nucleotides, about 4,600 nucleotides to about 7,400 nucleotides, about 4,600 nucleotides to about 7,200 nucleotides, about 4,600 nucleotides to about 7,000 nucleotides, about 4,600 nucleotides to about 6,800 nucleotides, about 4,600 nucleotides to about 6,600 nucleotides, about 4,600 nucleotides to about 6,400 nucleotides, about 4,600 nucleotides to about 6,200 nucleotides, about 4,600 nucleotides to about 6,000 nucleotides, about 4,600 nucleotides to about 5,800 nucleotides, about 4,600 nucleotides to about 5,600 nucleotides, about 4,600 nucleotides to about 5,400 nucleotides, about 4,600 nucleotides to about 5,200 nucleotides, about 4,600 nucleotides to about 5,000 nucleotides, about 4,600 nucleotides to about 4,800 nucleotides, about 4,800 nucleotides to about 10,000 nucleotides, about 4,800 nucleotides to about 9,500 nucleotides, about 4,800 nucleotides to about 9,000 nucleotides, about 4,800 nucleotides to about 8,500 nucleotides, about 4,800 nucleotides to about 8,000 nucleotides, about 4,800 nucleotides to about 7,800 nucleotides, about 4,800 nucleotides to about 7,600 nucleotides, about 4,800 nucleotides to about 7,400 nucleotides, about 4,800 nucleotides to about 7,200 nucleotides, about 4,800 nucleotides to about 7,000 nucleotides, about 4,800 nucleotides to about 6,800 nucleotides, about 4,800 nucleotides to about 6,600 nucleotides, about 4,800 nucleotides to about 6,400 nucleotides, about 4,800 nucleotides to about 6,200 nucleotides, about 4,800 nucleotides to about 6,000 nucleotides, about 4,800 nucleotides to about 5,800 nucleotides, about 4,800 nucleotides to about 5,600 nucleotides, about 4,800 nucleotides to about 5,400 nucleotides, about 4,800 nucleotides to about 5,200 nucleotides, about 4,800 nucleotides to about 5,000 nucleotides, about 5,000 nucleotides to about 10,000 nucleotides, about 5,000 nucleotides to about 9,500 nucleotides, about 5,000 nucleotides to about 9,000 nucleotides, about 5,000 nucleotides to about 8,500 nucleotides, about 5,000 nucleotides to about 8,000 nucleotides, about 5,000 nucleotides to about 7,800 nucleotides, about 5,000 nucleotides to about 7,600 nucleotides, about 5,000 nucleotides to about 7,400 nucleotides, about 5,000 nucleotides to about 7,200 nucleotides, about 5,000 nucleotides to about 7,000 nucleotides, about 5,000 nucleotides to about 6,800 nucleotides, about 5,000 nucleotides to about 6,600 nucleotides, about 5,000 nucleotides to about 6,400 nucleotides, about 5,000 nucleotides to about 6,200 nucleotides, about 5,000 nucleotides to about 6,000 nucleotides, about 5,000 nucleotides to about 5,800 nucleotides, about 5,000 nucleotides to about 5,600 nucleotides, about 5,000 nucleotides to about 5,400 nucleotides, about 5,000 nucleotides to about 5,200 nucleotides, about 5,200 nucleotides to about 10,000 nucleotides, about 5,200 nucleotides to about 9,500 nucleotides, about 5,200 nucleotides to about 9,000 nucleotides, about 5,200 nucleotides to about 8,500 nucleotides, about 5,200 nucleotides to about 8,000 nucleotides, about 5,200 nucleotides to about 7,800 nucleotides, about 5,200 nucleotides to about 7,600 nucleotides, about 5,200 nucleotides to about 7,400 nucleotides, about 5,200 nucleotides to about 7,200 nucleotides, about 5,200 nucleotides to about 7,000 nucleotides, about 5,200 nucleotides to about 6,800 nucleotides, about 5,200 nucleotides to about 6,600 nucleotides, about 5,200 nucleotides to about 6,400 nucleotides, about 5,200 nucleotides to about 6,200 nucleotides, about 5,200 nucleotides to about 6,000 nucleotides, about 5,200 nucleotides to about 5,800 nucleotides, about 5,200 nucleotides to about 5,600 nucleotides, about 5,200 nucleotides to about 5,400 nucleotides, about 5,400 nucleotides to about 10,000 nucleotides, about 5,400 nucleotides to about 9,500 nucleotides, about 5,400 nucleotides to about 9,000 nucleotides, about 5,400 nucleotides to about 8,500 nucleotides, about 5,400 nucleotides to about 8,000 nucleotides, about 5,400 nucleotides to about 7,800 nucleotides, about 5,400 nucleotides to about 7,600 nucleotides, about 5,400 nucleotides to about 7,400 nucleotides, about 5,400 nucleotides to about 7,200 nucleotides, about 5,400 nucleotides to about 7,000 nucleotides, about 5,400 nucleotides to about 6,800 nucleotides, about 5,400 nucleotides to about 6,600 nucleotides, about 5,400 nucleotides to about 6,400 nucleotides, about 5,400 nucleotides to about 6,200 nucleotides, about 5,400 nucleotides to about 6,000 nucleotides, about 5,400 nucleotides to about 5,800 nucleotides, about 5,400 nucleotides to about 5,600 nucleotides, about 5,600 nucleotides to about 10,000 nucleotides, about 5,600 nucleotides to about 9,500 nucleotides, about 5,600 nucleotides to about 9,000 nucleotides, about 5,600 nucleotides to about 8,500 nucleotides, about 5,600 nucleotides to about 8,000 nucleotides, about 5,600 nucleotides to about 7,800 nucleotides, about 5,600 nucleotides to about 7,600 nucleotides, about 5,600 nucleotides to about 7,400 nucleotides, about 5,600 nucleotides to about 7,200 nucleotides, about 5,600 nucleotides to about 7,000 nucleotides, about 5,600 nucleotides to about 6,800 nucleotides, about 5,600 nucleotides to about 6,600 nucleotides, about 5,600 nucleotides to about 6,400 nucleotides, about 5,600 nucleotides to about 6,200 nucleotides, about 5,600 nucleotides to about 6,000 nucleotides, about 5,600 nucleotides to about 5,800 nucleotides, about 5,800 nucleotides to about 10,000 nucleotides, about 5,800 nucleotides to about 9,500 nucleotides, about 5,800 nucleotides to about 9,000 nucleotides, about 5,800 nucleotides to about 8,500 nucleotides, about 5,800 nucleotides to about 8,000 nucleotides, about 5,800 nucleotides to about 7,800 nucleotides, about 5,800 nucleotides to about 7,600 nucleotides, about 5,800 nucleotides to about 7,400 nucleotides, about 5,800 nucleotides to about 7,200 nucleotides, about 5,800 nucleotides to about 7,000 nucleotides, about 5,800 nucleotides to about 6,800 nucleotides, about 5,800 nucleotides to about 6,600 nucleotides, about 5,800 nucleotides to about 6,400 nucleotides, about 5,800 nucleotides to about 6,200 nucleotides, about 5,800 nucleotides to about 6,000 nucleotides, about 6,000 nucleotides to about 10,000 nucleotides, about 6,000 nucleotides to about 9,500 nucleotides, about 6,000 nucleotides to about 9,000 nucleotides, about 6,000 nucleotides to about 8,500 nucleotides, about 6,000 nucleotides to about 8,000 nucleotides, about 6,000 nucleotides to about 7,800 nucleotides, about 6,000 nucleotides to about 7,600 nucleotides, about 6,000 nucleotides to about 7,400 nucleotides, about 6,000 nucleotides to about 7,200 nucleotides, about 6,000 nucleotides to about 7,000 nucleotides, about 6,000 nucleotides to about 6,800 nucleotides, about 6,000 nucleotides to about 6,600 nucleotides, about 6,000 nucleotides to about 6,400 nucleotides, about 6,000 nucleotides to about 6,200 nucleotides, about 6,200 nucleotides to about 10,000 nucleotides, about 6,200 nucleotides to about 9,000 nucleotides, about 6,200 nucleotides to about 8,500 nucleotides, about 6,200 nucleotides to about 8,000 nucleotides, about 6,200 nucleotides to about 7,800 nucleotides, about 6,200 nucleotides to about 7,600 nucleotides, about 6,200 nucleotides to about 7,400 nucleotides, about 6,200 nucleotides to about 7,200 nucleotides, about 6,200 nucleotides to about 7,000 nucleotides, about 6,200 nucleotides to about 6,800 nucleotides, about 6,200 nucleotides to about 6,600 nucleotides, about 6,200 nucleotides to about 6,400 nucleotides, about 6,400 nucleotides to about 10,000 nucleotides, about 6,400 nucleotides to about 9,500 nucleotides, about 6,400 nucleotides to about 9,000 nucleotides, about 6,400 nucleotides to about 8,500 nucleotides, about 6,400 nucleotides to about 8,000 nucleotides, about 6,400 nucleotides to about 7,800 nucleotides, about 6,400 nucleotides to about 7,600 nucleotides, about 6,400 nucleotides to about 7,400 nucleotides, about 6,400 nucleotides to about 7,200 nucleotides, about 6,400 nucleotides to about 7,000 nucleotides, about 6,400 nucleotides to about 6,800 nucleotides, about 6,400 nucleotides to about 6,600 nucleotides, about 6,600 nucleotides to about 10,000 nucleotides, about 6,600 nucleotides to about 9,500 nucleotides, about 6,600 nucleotides to about 9,000 nucleotides, about 6,600 nucleotides to about 8,500 nucleotides, about 6,600 nucleotides to about 8,000 nucleotides, about 6,600 nucleotides to about 7,800 nucleotides, about 6,600 nucleotides to about 7,600 nucleotides, about 6,600 nucleotides to about 7,400 nucleotides, about 6,600 nucleotides to about 7,200 nucleotides, about 6,600 nucleotides to about 7,000 nucleotides, about 6,600 nucleotides to about 6,800 nucleotides, about 6,800 nucleotides to about 10,000 nucleotides, about 6,800 nucleotides to about 9,500 nucleotides, about 6,800 nucleotides to about 9,000 nucleotides, about 6,800 nucleotides to about 8,500 nucleotides, about 6,800 nucleotides to about 8,000 nucleotides, about 6,800 nucleotides to about 7,800 nucleotides, about 6,800 nucleotides to about 7,600 nucleotides, about 6,800 nucleotides to about 7,400 nucleotides, about 6,800 nucleotides to about 7,200 nucleotides, about 6,800 nucleotides to about 7,000 nucleotides, about 7,000 nucleotides to about 10,000 nucleotides, about 7,000 nucleotides to about 9,500 nucleotides, about 7,000 nucleotides to about 9,000 nucleotides, about 7,000 nucleotides to about 8,500 nucleotides, about 7,000 nucleotides to about 8,000 nucleotides, about 7,000 nucleotides to about 7,800 nucleotides, about 7,000 nucleotides to about 7,600 nucleotides, about 7,000 nucleotides to about 7,400 nucleotides, about 7,000 nucleotides to about 7,200 nucleotides, about 7,200 nucleotides to about 10,000 nucleotides, about 7,200 nucleotides to about 9,500 nucleotides, about 7,200 nucleotides to about 9,000 nucleotides, about 7,200 nucleotides to about 8,500 nucleotides, about 7,200 nucleotides to about 8,000 nucleotides, about 7,200 nucleotides to about 7,800 nucleotides, about 7,200 nucleotides to about 7,600 nucleotides, about 7,200 nucleotides to about 7,400 nucleotides, about 7,400 nucleotides to about 10,000 nucleotides, about 7,400 nucleotides to about 9,500 nucleotides, about 7,400 nucleotides to about 9,000 nucleotides, about 7,400 nucleotides to about 8,500 nucleotides, about 7,400 nucleotides to about 8,000 nucleotides, about 7,400 nucleotides to about 7,800 nucleotides, about 7,400 nucleotides to about 7,600 nucleotides, about 7,600 nucleotides to about 10,000 nucleotides, about 7,600 nucleotides to about 9,500 nucleotides, about 7,600 nucleotides to about 9,000 nucleotides, about 7,600 nucleotides to about 8,500 nucleotides, about 7,600 nucleotides to about 8,000 nucleotides, about 7,600 nucleotides to about 7,800 nucleotides, about 7,800 nucleotides to about 10,000 nucleotides, about 7,800 nucleotides to about 9,500 nucleotides, about 7,800 nucleotides to about 9,000 nucleotides, about 7,800 nucleotides to about 8,500 nucleotides, about 7,800 nucleotides to about 8,000 nucleotides, about 8,000 nucleotides to about 10,000 nucleotides, about 8,000 nucleotides to about 9,500 nucleotides, about 8,000 nucleotides to about 9,000 nucleotides, about 8,000 nucleotides to about 8,500 nucleotides, about 8,500 nucleotides to about 10,000 nucleotides, about 8,500 nucleotides to about 9,500 nucleotides, about 8,500 nucleotides to about 9,000 nucleotides, about 9,000 nucleotides to about 10,000 nucleotides, about 9,000 nucleotides to about 9,500 nucleotides, or about 9,500 nucleotides to about 10,000 nucleotides (inclusive).

[0253] A variety of different methods known in the art can be used to introduce any of vectors disclosed herein into a primate cell (e.g., a supporting cochlear outer hair cell or a hair cell (e.g., an inner hair cell or an outer hair cell). Non-limiting examples of methods for introducing nucleic acid into a primate cell include: lipofection, transfection (e.g., calcium phosphate transfection, transfection using highly branched organic compounds, transfection using cationic polymers, dendrimer-based transfection, optical transfection, particle-based transfection (e.g., nanoparticle transfection), or transfection using liposomes (e.g., cationic liposomes)), microinjection, electroporation, cell squeezing, sonoporation, protoplast fusion, impalefection, hydrodynamic delivery, gene gun, magnetofection, viral transfection, and nucleofection.

[0254] Skilled practitioners will appreciate that any of the vectors described herein can be introduced into a primate cell by, for example, lipofection.

[0255] Various molecular biology techniques that can be used to introduce a mutation(s) and/or a deletion(s) into an endogenous gene are also known in the art. Non-limiting examples of such techniques include site-directed mutagenesis, CRISPR (e.g., CRISPR/Cas9-induced knock-in mutations and CRISPR/Cas9-induced knock-out mutations), TALENs, and base editing (Rees & Lui, Nature Rev. Genetics 19: 770-788, 2018; Eid et al., Biochem J. 475(11): 1955-1964, 2018). These methods can be used to correct the sequence of a defective endogenous gene present in a chromosome of a target cell.

[0256] Any of the vectors described herein can further include a control sequence, e.g., a control sequence selected from the group of a transcription initiation sequence, a transcription termination sequence, a promoter sequence, an enhancer sequence, an RNA splicing sequence, a polyadenylation (polyA) sequence, and a Kozak consensus sequence. Non-limiting examples of these control sequences are described herein. In some embodiments, a promoter can be a native promoter, a constitutive promoter, an inducible promoter, and/or a tissue-specific promoter.

[0257] Some embodiments of any of the compositions and kits described herein can include any combination of the AAV vectors described herein. Some embodiments of any of the methods described herein can include the use of any combination of the AAV vectors described herein.

Promoters

[0258] The term “promoter” means a DNA sequence recognized by enzymes/proteins in a primate cell required to initiate the transcription of a specific gene (e.g., a supporting cell target gene or a hair cell target gene). A promoter typically refers to, e.g., a nucleotide sequence to which an RNA polymerase and/or any associated factor binds and at which transcription is initiated. Non-limiting examples of promoters are described herein. Additional examples of promoters are known in the art.

[0259] In some embodiments, a vector encoding an N-terminal portion of a hair cell target protein (e.g., a human hair cell target protein) or a hair cell target protein can include a promoter and/or an enhancer. The vector encoding the N-terminal portion of the hair cell target protein or a hair cell target protein can include any of the promoters and/or enhancers described herein or known in the art.

[0260] In some embodiments, a vector encoding an N-terminal portion of a supporting cell target protein (e.g., a human supporting cell target protein) or a supporting cell target protein can include a promoter and/or an enhancer. The vector encoding the N-terminal portion of the supporting cell target protein or a supporting cell target protein can include any of the promoters and/or enhancers described herein or known in the art.

[0261] In some embodiments, the promoter is an inducible promoter, a constitutive promoter, a primate cell promoter, a viral promoter, a chimeric promoter, an engineered promoter, a tissue-specific promoter, or any other type of promoter known in the art. In some embodiments, the promoter is a RNA polymerase II promoter, such as a primate RNA polymerase II promoter. In some embodiments, the promoter is a RNA polymerase III promoter, including, but not limited to, a H1 promoter, a human U6 promoter, a mouse U6 promoter, or a swine U6 promoter. The promoter will generally be one that is able to promote transcription in cochlear cells such as hair cells. In some examples, the promoter is a cochlea-specific promoter or a cochlea-oriented promoter.

[0262] A variety of promoters are known in the art that can be used herein. Non-limiting examples of promoters that can be used herein include: human EF1a, human cytomegalovirus (CMV) (U.S. Pat. No. 5,168,062), human ubiquitin C (UBC), mouse phosphoglycerate kinase 1, polyoma adenovirus, simian virus 40 (SV40), β-globin, β-actin, α-fetoprotein, γ-globin, β-interferon, γ-glutamyl transferase, mouse mammary tumor virus (MMTV), Rous sarcoma virus, rat insulin, glyceraldehyde-3-phosphate dehydrogenase, metallothionein II (MT II), amylase, cathepsin, MI muscarinic receptor, retroviral LTR (e.g. human T-cell leukemia virus HTLV), AAV ITR, interleukin-2, collagenase, platelet-derived growth factor, adenovirus 5 E2, stromelysin, murine MX gene, glucose regulated proteins (GRP78 and GRP94), α-2-macroglobulin, vimentin, MHC class I gene H-2κ b, HSP70, proliferin, tumor necrosis factor, thyroid stimulating hormone a gene, immunoglobulin light chain, T-cell receptor, HLA DQα and DQβ, interleukin-2 receptor, MHC class II, MHC class II HLA-DRα, muscle creatine kinase, prealbumin (transthyretin), elastase I, albumin gene, c-fos, c-HA-ras, neural cell adhesion molecule (NCAM), H2B (TH2B) histone, rat growth hormone, human serum amyloid (SAA), troponin I (TN I), duchenne muscular dystrophy, human immunodeficiency virus, and Gibbon Ape Leukemia Virus (GALV) promoters. Additional examples of promoters are known in the art. See, e.g., Lodish, Molecular Cell Biology, Freeman and Company, New York 2007. In some embodiments, the promoter is the CMV immediate early promoter. In some embodiments, the promoter is a CAG promoter or a CAG/CBA promoter.

[0263] The term “constitutive” promoter refers to a nucleotide sequence that, when operably linked with a nucleic acid encoding a target protein (e.g., a supporting cell target protein, a hair cell target protein), causes RNA to be transcribed from the nucleic acid in a primate cell under most or all physiological conditions.

[0264] Examples of constitutive promoters include, without limitation, the retroviral Rous sarcoma virus (RSV) LTR promoter, the cytomegalovirus (CMV) promoter (see, e.g., Boshart et al, Cell 41:521-530, 1985), the SV40 promoter, the dihydrofolate reductase promoter, the beta-actin promoter, the phosphoglycerol kinase (PGK) promoter, and the EF1-alpha promoter (Invitrogen).

[0265] Inducible promoters allow regulation of gene expression and can be regulated by exogenously supplied compounds, environmental factors such as temperature, or the presence of a specific physiological state, e.g., acute phase, a particular differentiation state of the cell, or in replicating cells only. Inducible promoters and inducible systems are available from a variety of commercial sources, including, without limitation, Invitrogen, Clontech, and Ariad. Additional examples of inducible promoters are known in the art.

[0266] Examples of inducible promoters regulated by exogenously supplied compounds include the zinc-inducible sheep metallothionine (MT) promoter, the dexamethasone (Dex)-inducible mouse mammary tumor virus (MMTV) promoter, the T7 polymerase promoter system (WO 98/10088); the ecdysone insect promoter (No et al, Proc. Natl. Acad. Sci. U.S.A. 93:3346-3351, 1996), the tetracycline-repressible system (Gossen et al, Proc. Natl. Acad. Sci. U.S.A. 89:5547-5551, 1992), the tetracycline-inducible system (Gossen et al, Science 268:1766-1769, 1995, see also Harvey et al, Curr. Opin. Chem. Biol. 2:512-518, 1998), the RU486-inducible system (Wang et al, Nat. Biotech. 15:239-243, 1997) and Wang et al, Gene Ther. 4:432-441, 1997), and the rapamycin-inducible system (Magari et al. J. Clin. Invest. 100:2865-2872, 1997).

[0267] The term “tissue-specific” promoter refers to a promoter that is active only in certain specific cell types and/or tissues (e.g., transcription of a specific gene occurs only within cells expressing transcription regulatory proteins that bind to the tissue-specific promoter).

[0268] In some embodiments, the regulatory sequences impart tissue-specific gene expression capabilities. In some cases, the tissue-specific regulatory sequences bind tissue-specific transcription factors that induce transcription in a tissue-specific manner.

[0269] Exemplary tissue-specific promoters include but are not limited to the following: a liver-specific thyroxin binding globulin (TBG) promoter, an insulin promoter, a glucagon promoter, a somatostatin promoter, a pancreatic polypeptide (PPY) promoter, a synapsin-1 (Syn) promoter, a creatine kinase (MCK) promoter, a primate desmin (DES) promoter, an alpha-myosin heavy chain (a-MHC) promoter, and a cardiac Troponin T (cTnT) promoter. Additional exemplary promoters include Beta-actin promoter, hepatitis B virus core promoter (Sandig et al., Gene Ther. 3:1002-1009, 1996), alpha-fetoprotein (AFP) promoter (Arbuthnot et al., Hum. Gene Ther. 7:1503-1514, 1996), bone osteocalcin promoter (Stein et al., Mol. Biol. Rep. 24:185-196, 1997); bone sialoprotein promoter (Chen et al., J. Bone Miner. Res. 11:654-664, 1996), CD2 promoter (Hansal et al., J. Immunol. 161:1063-1068, 1998); immunoglobulin heavy chain promoter; T cell receptor alpha-chain promoter, neuronal such as neuron-specific enolase (NSE) promoter (Andersen et al., Cell. Mol. Neurobiol. 13:503-515, 1993), neurofilament light-chain gene promoter (Piccioli et al., Proc. Natl. Acad. Sci. U.S.A. 88:5611-5615, 1991), and the neuron-specific vgf gene promoter (Piccioli et al., Neuron 15:373-384, 1995).

[0270] In some embodiments, the tissue-specific promoter is a cochlea-specific promoter. In some embodiments, the tissue-specific promoter is a cochlear hair cell-specific promoter. Non-limiting examples of cochlear hair cell-specific promoters include but are not limited to: a ATOH1 promoter, a POU4F3 promoter, a LHX3 promoter, a MYO7A promoter, a MYO6 promoter, a α9ACHR promoter, and a α10ACHR promoter. In some embodiments, the promoter is an outer hair cell-specific promoter such as a PRESTIN promoter or an ONCOMOD promoter. See, e.g., Zheng et al., Nature 405:149-155, 2000; Tian et al. Dev. Dyn. 231:199-203, 2004; and Ryan et al., Adv. Otorhinolaryngol. 66: 99-115, 2009.

[0271] In some embodiments of any of the AAV vectors described herein, the AAV vector includes a human ATOH1 enhancer-promoter (SEQ ID NO: 84).

TABLE-US-00024 Human ATOH1 enhancer-promoter (SEQ ID NO: 84) ctatggagtttgcataacaaacgtttggcagctcgctctottacactccattaacaagctgtaacatatag ctgcaggttgctataatctcattaatattttggaaacttgaatattgagtatttctgagtgctcattcccc atatgccagccacttctgccatgctgactggttcctttctctccattattagcaattagcttcttaccttc caaagtcagatccaaggtatccaagatactagcaaaggaatcaactatgtgtgcaagttaagcatgcttaa tatcacccaaacaaacaaagaggcagcatttcttaaagtaatgaagatagataaatcgggttagtcctttg cgacactgctggtgctttctagagttttatatattttaagcagcttgctttatattctgtctttgcctccc accccaccagcacttttatttgtggagggttttggctcgccacactttgggaaacttatttgatttcacgg agagctgaaggaagatcatttttggcaacagacaagtttaaacacgatttctatgggacattgctaactgg ggcccctaaggagaaaggggaaactgagcggagaatgggttaaatccttggaagcaggggagaggcagggg aggagagaagtcggaggagtataaagaaaaggacaggaaccaagaagcgtgggggtggtttgccgtaatgt gagtgtttcttaattagagaacggttgacaatagagggtctggcagaggctcctggccgcggtgcggagcg tctggagcggagcacgcgctgtcagctggtgagcgcactctcctttcaggcagctccccggggagctgtgc ggccacatttaacaccatcatcacccctccccggcctcctcaacctcggcctcctcctcgtcgacagcctt ccttggcccccaccagcagagctcacagtagcgagcgtctctcgccgtctcccgcactcggccggggcctc tctcctcccccagctgcgcagcgggagccgccactgcccactgcacctcccagcaaccagcccagcacgca aagaagctgcgcaaagttaaagccaagcaatgccaaggggaggggaagctggaggcgggctttgagtggct tctgggcgcctggcgggtccagaatcgcccagagccgcccgcggtcgtgcacatctgacccgagtcagctt gggcaccagccgagagccggctccgcaccgctcccgcaccccagccgccggggtggtgacacacaccggag tcgaattacagccctgcaattaacatatgaatctgacgaatttaaaagaaggaaaaaaaaaaaaaaacctg agcaggcttgggagtcctctgcacacaagaacttttctcggggtgtaaaaactctttgattggctgctcgc acgcgcctgcccgcgccctccattggctgagaagacacgcgaccggcgcgaggagggggttgggagaggag cggggggagactgagtggcgcgtgccgctttttaaaggggcgcagcgccttcagcaaccggagaagcatag ttgcacgcgacctggtgtgtgatctccgagtgggtgggggagggtcgaggagggaaaaaaaaataagacgt tgcagaagagacccggaaagggccttttttttggttgagctggtgtcccagtgctgcctccgatcctgagc ctccgagcctttgcagtgcaa

Enhancers and 5′ Cap

[0272] In some instances, a vector can include a promoter sequence and/or an enhancer sequence. The term “enhancer” refers to a nucleotide sequence that can increase the level of transcription of a nucleic acid encoding a protein of interest (e.g., a supporting cell target protein or a hair cell target protein) Enhancer sequences (50-1500 basepairs in length) generally increase the level of transcription by providing additional binding sites for transcription-associated proteins (e.g., transcription factors). In some embodiments, an enhancer sequence is found within an intronic sequence. Unlike promoter sequences, enhancer sequences can act at much larger distance away from the transcription start site (e.g., as compared to a promoter). Non-limiting examples of enhancers include a RSV enhancer, a CMV enhancer, and a SV40 enhancer.

Destabilizing Domain (DD)

[0273] Any of the AAV vectors provided herein can optionally include a sequence encoding a destabilizing domain (“a destabilizing sequence”) for temporal control of protein expression. Non-limiting examples of destabilizing sequences include sequences encoding: a FK506 sequence, a dihydrofolate reductase (DHFR) sequence.

TABLE-US-00025 Exemplary DHFR destabilizing sequence (SEQ ID NO: 85): MISLIAALAVDYVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPSTDDR VTWVKSVDEAIAACGDVPEIMVIGGGRVIEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVESEFHD ADAQNSHSYCFEILERR Exemplary DHFR destabilizing domain sequence (SEQ ID NO: 86) ggtaccatcagtotgattqcggcgttagoggtagattacgttatoggcatggaaaacgccatgccgtggaa cctqcctqccgatctcgcctggtttaaacgcaacaccttaaataaacccgtgattatgggccgccatacct gggaatcaatoggtcgtccgttgccaggacgcaaaaatattatcctcagcagtcaaccgagtacggacgat cgcgtaacgtgggtgaagtoggtggatgaagccatcgcggcgtgtggtgacgtaccagaaatcatggtgat tggcggcggtcgcgttattgaacagttottgccaaaagcgcaaaaactqtatctgacgcatatcgacgcag aagtggaaggcgacacccatttccoggattacgagccggatgactgggaatcggtattcagcgaattccac gatqctgatqcgcagaactotcacagctattgotttgagattctggagoggcgataa

[0274] In some embodiments of any of the AAV vectors described herein, the AAV vector includes a destabilizing domain (SEQ ID NO: 87).

TABLE-US-00026 Exemplary destabilizing domain (SEQ ID NO: 87) atcagtctgattgoggcgttagcggtagattacgttatcggcatggaaaacgccatgccgtggaacctgcc tgccgatctcgcctggtttaaacgcaacaccttaaataaacccgtgattatgggccgccatacctgggaat caatcggtcgtccgttgccaggacgcaaaaatattatcctcagcagtcaaccgagtacggacgatcgcgta acgtgggtgaagtcggtggatgaagccatcgcggcgtgtggtgacgtaccagaaatcatggtgattggcgg cggtcgcgttattgaacagttcttgccaaaagcgcaaaaactgtatctgacgcatatcgacgcagaagtgg aaggcgacacccatttcccggattacgagccggatgactgggaatcggtattcagcgaattccacgatgct gatgcgcagaactctcacagctattgctttgagattctggagcggcga

[0275] Additional examples of destabilizing sequences are known in the art. In some embodiments, the destabilizing sequence is a FK506- and rapamycin-binding protein (FKBP12) sequence, and the stabilizing ligand is Shield-1 (Shld1) (Banaszynski et al. (2012) Cell 126(5): 995-1004).

TABLE-US-00027 Exemplary FKBP12 destabilizing sequence (SEQ ID NO: 88) MGVEKQVIRPGNGPKPAPGQTVTVHCTGEGKDGDLSQKFWSTKDEGQKPFSFQIGKGAVIKGWDEGVIGMQ IGEVARLRCSSDYAYGAGGFPAWGIQPNSVLDFEIEVLSVQ

[0276] In some embodiments, the destabilizing sequence is a DHFR sequence, and the stabilizing ligand is trimethoprim (TMP) (Iwamoto et al. (2010) Chem Biol 17:981-988).

[0277] In the absence of a stabilizing ligand, the protein sequence operatively linked to the destabilizing sequence is degraded by ubiquitination. In contrast, in the presence of a stabilizing ligand, protein degradation is inhibited, thereby allowing the protein sequence operatively linked to the destabilizing sequence to be actively expressed. As a positive control for stabilization of protein expression, protein expression can be detected by conventional means, including enzymatic, radiographic, colorimetric, fluorescence, or other spectrographic assays; fluorescent activating cell sorting (FACS) assays; immunological assays (e.g., enzyme linked immunosorbent assay (ELISA), radioimmunoassay (RIA), and immunohistochemistry).

[0278] In some embodiments, the destabilizing sequence is a FKBP12 sequence, and the presence of an AAV vector carrying the FKBP12 gene in a primate cell (e.g., a supporting cochlear outer hair cell) is detected by western blotting. In some embodiments, the destabilizing sequence can be used to verify the temporally-specific activity of any of the AAV vectors described herein.

Poly(A) Sequences

[0279] In some embodiments, any of the vectors provided herein can include a poly(A) sequence. Most nascent eukaryotic mRNAs possess a poly(A) tail at their 3′ end which is added during a complex process that includes cleavage of the primary transcript and a coupled polyadenylation reaction (see, e.g., Proudfoot et al., Cell 108:501-512, 2002). The poly(A) tail confers mRNA stability and transferability (Molecular Biology of the Cell, Third Edition by B. Alberts et al., Garland Publishing, 1994). In some embodiments, the poly(A) sequence is positioned 3′ to the nucleic acid sequence encoding the C-terminus of the hair cell target protein. In some embodiments, the poly(A) sequence is positioned 3′ to the nucleic acid sequence encoding the C-terminus of the supporting cell target protein or a protein of interest (e.g., a Cas9 endonuclease, e.g., a SaCas9 endonuclease (e.g., any of the SaCas9 endonucleases described herein), a reporter protein (e.g., a GFP protein, a mScarlet protein)).

[0280] As used herein, “polyadenylation” refers to the covalent linkage of a polyadenylyl moiety, or its modified variant, to a messenger RNA molecule. In eukaryotic organisms, most messenger RNA (mRNA) molecules are polyadenylated at the 3′ end. The 3′ poly(A) tail is a long sequence of adenine nucleotides (e.g., 50, 60, 70, 100, 200, 500, 1000, 2000, 3000, 4000, or 5000) added to the pre-mRNA through the action of an enzyme, polyadenylate polymerase. In higher eukaryotes, the poly(A) tail is added onto transcripts that contain a specific sequence, the polyadenylation signal or “poly(A) sequence.” The poly(A) tail and the protein bound to it aid in protecting mRNA from degradation by exonucleases. Polyadenylation is also important for transcription termination, export of the mRNA from the nucleus, and translation. Polyadenylation occurs in the nucleus immediately after transcription of DNA into RNA, but additionally can also occur later in the cytoplasm. After transcription has been terminated, the mRNA chain is cleaved through the action of an endonuclease complex associated with RNA polymerase. The cleavage site is usually characterized by the presence of the base sequence AAUAAA near the cleavage site. After the mRNA has been cleaved, adenosine residues are added to the free 3′ end at the cleavage site.

[0281] As used herein, a “poly(A) sequence” is a sequence that triggers the endonuclease cleavage of an mRNA and the additional of a series of adenosines to the 3′ end of the cleaved mRNA.

[0282] There are several poly(A) sequences that can be used, including those derived from bovine growth hormone (bgh) (Woychik et al., Proc. Natl. Acad. Sci. U.S.A. 81(13):3944-3948, 1984; U.S. Pat. No. 5,122,458), mouse-β-globin, mouse-α-globin (Orkin et al., EMBO J. 4(2):453-456, 1985; Thein et al., Blood 71(2):313-319, 1988), human collagen, polyoma virus (Batt et al., Mol. Cell Biol. 15(9):4783-4790, 1995), the Herpes simplex virus thymidine kinase gene (HSV TK), IgG heavy-chain gene polyadenylation signal (US 2006/0040354), human growth hormone (hGH) (Szymanski et al., Mol. Therapy 15(7):1340-1347, 2007), the group of SV40 poly(A) sites, such as the SV40 late and early poly(A) site (Schek et al., Mol. Cell Biol. 12(12):5386-5393, 1992).

[0283] The poly(A) sequence can be a sequence of AATAAA. The AATAAA sequence may be substituted with other hexanucleotide sequences with homology to AATAAA which are capable of signaling polyadenylation, including ATTAAA, AGTAAA, CATAAA, TATAAA, GATAAA, ACTAAA, AATATA, AAGAAA, AATAAT, AAAAAA, AATGAA, AATCAA, AACAAA, AATCAA, AATAAC, AATAGA, AATTAA, or AATAAG (see, e.g., WO 06/12414).

[0284] In some embodiments, the poly(A) sequence can be a synthetic polyadenylation site (see, e.g., the pCl-neo expression vector of Promega which is based on Levitt el al, Genes Dev. 3(7):1019-1025, 1989). In some embodiments, the poly(A) sequence is the polyadenylation signal of soluble neuropilin-1 (sNRP) (AAATAAAATACGAAATG, SEQ ID NO: 90) (see, e.g., WO 05/073384). Additional examples of poly(A) sequences are known in the art.

Internal Ribosome Entry Site (IRES)

[0285] In some embodiments, a vector encoding the C-terminus of the hair cell target protein or a hair cell target protein can include a polynucleotide internal ribosome entry site (IRES). In some embodiments, a vector encoding the C-terminus of the supporting cell target protein or a supporting cell target protein can include a polynucleotide internal ribosome entry site (IRES). An IRES sequence is used to produce more than one polypeptide from a single gene transcript. An IRES forms a complex secondary structure that allows translation initiation to occur from any position with an mRNA immediately downstream from where the IRES is located (see, e.g., Pelletier and Sonenberg, Mol. Cell. Biol. 8(3):1103-1112, 1988).

[0286] There are several IRES sequences known to those in skilled in the art, including those from, e.g., foot and mouth disease virus (FMDV), encephalomyocarditis virus (EMCV), human rhinovirus (HRV), cricket paralysis virus, human immunodeficiency virus (11W), hepatitis A virus (HAV), hepatitis C virus (HCV), and poliovirus (PV). See e.g., Alberts, Molecular Biology of the Cell, Garland Science, 2002; and Hellen et al., Genes Dev. 15(13):1593-612, 2001.

[0287] In some embodiments, the IRES sequence that is incorporated into the vector that encodes the C-terminus of a hair cell target protein or a hair cell target protein is the foot and mouth disease virus (FMDV). In some embodiments, the IRES sequence that is incorporated into the vector that encodes the C-terminus of a supporting cell target protein or a supporting cell target protein is the foot and mouth disease virus (FMDV) 2A sequence. In some embodiments, the IRES sequence that is incorporated into the vector that encodes the C-terminal portion of a protein of interest (e.g., a Cas9 endonuclease, e.g., a SaCas9 endonuclease (e.g., any of the SaCas9 endonucleases described herein)) is the FMDV 2A sequence. The Foot and Mouth Disease Virus 2A sequence is a small peptide (approximately 18 amino acids in length) that has been shown to mediate the cleavage of polyproteins (Ryan, M D et al., EMBO 4:928-933, 1994; Mattion et al., J. Virology 70:8124-8127, 1996; Furler et al., Gene Therapy 8:864-873, 2001; and Halpin et al., Plant Journal 4:453-459, 1999). The cleavage activity of the 2A sequence has previously been demonstrated in artificial systems including plasmids and gene therapy vectors (AAV and retroviruses) (Ryan et al., EMBO 4:928-933, 1994; Mattion et al., J. Virology 70:8124-8127, 1996; Furler et al., Gene Therapy 8:864-873, 2001; and Halpin et al., Plant Journal 4:453-459, 1999; de Felipe et al., Gene Therapy 6:198-208, 1999; de Felipe et al., Human Gene Therapy 11:1921-1931, 2000; and Klump et al., Gene Therapy 8:811-817, 2001).

Reporter Sequences/Detectable Marker Genes

[0288] Any of the vectors provided herein can optionally include a sequence encoding a reporter protein or a detectable marker (“a reporter sequence” or “detectable marker gene”). Non-limiting examples of reporter sequences or detectable marker genes include DNA sequences encoding: a beta-lactamase, a beta-galactosidase (LacZ), an alkaline phosphatase, a thymidine kinase, a green fluorescent protein (GFP), a red fluorescent protein, an mCherry fluorescent protein, a yellow fluorescent protein, a chloramphenicol acetyltransferase (CAT), and a luciferase. Additional examples of reporter sequences and detectable marker genes are known in the art. When associated with regulatory elements which drive their expression, the reporter sequence or detectable marker gene can provide signals detectable by conventional means, including enzymatic, radiographic, colorimetric, fluorescence, or other spectrographic assays; fluorescent activating cell sorting (FACS) assays; immunological assays (e.g., enzyme linked immunosorbent assay (ELISA), radioimmunoassay (RIA), and immunohistochemistry).

[0289] In some embodiments, the reporter sequence or detectable marker gene is the LacZ gene, and the presence of a vector carrying the LacZ gene in a primate cell (e.g., a supporting cochlear outer hair cell or a hair cell (e.g., a cochlear outer hair cell or a cochlear inner hair cell)) is detected by assays for beta-galactosidase activity. In other embodiments, the reporter or detectable marker is a fluorescent protein (e.g., green fluorescent protein) or luciferase, the presence of a vector carrying the fluorescent protein or luciferase in a primate cell (e.g., a supporting cochlear outer hair cell or a hair cell (e.g., a cochlear outer hair cell, a cochlear inner hair cell)) may be measured by fluorescent techniques (e.g., fluorescent microscopy or FACS) or light production in a luminometer (e.g., a spectrophotometer or an IVIS imaging instrument). In some embodiments, the reporter sequence or detectable marker can be used to verify the tissue-specific targeting capabilities and tissue-specific promoter regulatory activity of any of the vectors described herein.

Flanking Regions Untranslated Regions (UTRs)

[0290] In some embodiments, any of the vectors described herein (e.g., any of the at least two different vectors) can include an untranslated region. In some embodiments, a vector can includes a 5′ UTR or a 3′ UTR.

[0291] Untranslated regions (UTRs) of a gene are transcribed but not translated. The 5′ UTR starts at the transcription start site and continues to the start codon but does not include the start codon. The 3′ UTR starts immediately following the stop codon and continues until the transcriptional termination signal. There is growing body of evidence about the regulatory roles played by the UTRs in terms of stability of the nucleic acid molecule and translation. The regulatory features of a UTR can be incorporated into any of the vectors, compositions, kits, or methods as described herein to enhance the stability of a supporting cell target protein or a hair cell target protein or of a protein of interest (e.g., a Cas9 endonuclease, e.g., a SaCas9 endonuclease (e.g., any of the SaCas9 endonucleases described herein), a reporter protein (e.g., a GFP protein, a mScarlet protein).

[0292] Natural 5′ UTRs include a sequence that plays a role in translation initiation. They harbor signatures like Kozak sequences, which are commonly known to be involved in the process by which the ribosome initiates translation of many genes. Kozak sequences have the consensus sequence CCR(A/G)CCAUGG, where R is a purine (A or G) three bases upstream of the start codon (AUG), which is followed by another “G”. The 5′ UTR have also been known, e.g., to form secondary structures that are involved in elongation factor binding.

[0293] For example, in some embodiments, a 5′ UTR is included in any of the vectors described herein. Non-limiting examples of 5′ UTRs including those from the following genes: albumin, serum amyloid A, Apolipoprotein A/B/E, transferrin, alpha fetoprotein, erythropoietin, and Factor VIII, can be used to enhance expression of a nucleic acid molecule, such as a mRNA.

[0294] In some embodiments, a 5′ UTR from a mRNA that is transcribed by a cell in the cochlea can be included in any of the vectors, compositions, kits, and methods described herein.

[0295] 3′ UTRs are known to have stretches of adenosines and uridines embedded in them. These AU-rich signatures are particularly prevalent in genes with high rates of turnover. Based on their sequence features and functional properties, the AU-rich elements (AREs) can be separated into three classes (Chen et al., Mol. Cell. Biol. 15:5777-5788, 1995; Chen et al., Mol. Cell Biol. 15:2010-2018, 1995): Class I AREs contain several dispersed copies of an AUUUA motif within U-rich regions. For example, c-Myc and MyoD mRNAs contain class I AREs. Class II AREs possess two or more overlapping UUAUUUA(U/A) (U/A) nonamers. GM-CSF and TNF-alpha mRNAs are examples that contain class II AREs. Class III AREs are less well defined. These U-rich regions do not contain an AUUUA motif. Two well-studied examples of this class are c-Jun and myogenin mRNAs.

[0296] Most proteins binding to the AREs are known to destabilize the messenger, whereas members of the ELAV family, most notably HuR, have been documented to increase the stability of mRNA. HuR binds to AREs of all the three classes. Engineering the HuR specific binding sites into the 3′ UTR of nucleic acid molecules will lead to HuR binding and thus, stabilization of the message in vivo.

[0297] In some embodiments, the introduction, removal, or modification of 3′ UTR AREs can be used to modulate the stability of an mRNA encoding a hair cell target protein. In some embodiments, the introduction, removal, or modification of 3′ UTR

[0298] AREs can be used to modulate the stability of an mRNA encoding a supporting cell target protein. In other embodiments, AREs can be removed or mutated to increase the intracellular stability and thus increase translation and production of a hair cell target protein. In other embodiments, AREs can be removed or mutated to increase the intracellular stability and thus increase translation and production of a supporting cell target protein.

[0299] In other embodiments, non-UTR sequences may be incorporated into the 5′ or 3′ UTRs. In some embodiments, introns or portions of intron sequences may be incorporated into the flanking regions of the polynucleotides in any of the vectors, compositions, kits, and methods provided herein. Incorporation of intronic sequences may increase protein production as well as mRNA levels.

Primate Cells

[0300] Also provided herein is a cell (e.g., a primate cell) that includes any of the nucleic acids, vectors (e.g., at least two different vectors described herein), or compositions described herein. In some embodiments, the primate cell is a human cell (e.g., a human supporting cell or a human hair cell). In other embodiments, the primate is a non-human primate (e.g., simian cell (e.g., a monkey cell (e.g., a marmoset cell, a baboon cell, a macaque cell), or an ape cell (e.g., a gorilla cell, a gibbon cell, an orangutan cell, a chimpanzee cell). Skilled practitioners will appreciate that the nucleic acids and vectors described herein can be introduced into any primate cell (e.g., a primate supporting cell or a primate hair cell). Non-limiting examples of vectors and methods for introducing vectors into primate cells are described herein.

[0301] In some embodiments, the primate cell can be a supporting hair cell of the inner ear of a mammal. For example, a supporting cell can be Hensen's cells, Deiters' cells, inner pillar cells, outer pillar cells, Claudius cells, inner border cells, inner phalangeal cells, or cells of the stria vascularis.

[0302] In some embodiments, the primate cell is a specialized cell of the cochlea. In some embodiments, the primate cell is a hair cell. In some embodiments, the primate cell is a cochlear inner hair cell or a cochlear outer hair cell. In some embodiments, the primate cell is a cochlear inner hair cell. In some embodiments, the primate cell is a cochlear outer hair cell.

[0303] In some embodiments, the primate cell is in vitro. In some embodiments, the primate cell is present in a primate. In some embodiments, the primate cell is autologous cell obtained from a primate and cultured ex vivo.

Methods

[0304] Also provided herein are methods of correcting a hair cell target gene defect in a hair cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the hair cell target gene defect in the hair cell of the inner ear of the primate.

[0305] Also provided herein are methods of increasing the expression level of a hair cell target protein in a hair cell of an inner ear of a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering results in an increase in the expression level of the hair cell target protein in the hair cell of the inner ear of the primate.

[0306] Also provided herein are methods of treating hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss) in a primate identified as having a defective hair cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

[0307] In some embodiments of any of these methods, the primate has been previously identified as having a defective hair cell target gene (e.g., a hair cell target gene having a mutation that results in a decrease in the expression and/or activity of a hair cell target protein encoded by the gene). Some embodiments of any of these methods further include, prior to the introducing or administering step, determining that the primate has a defective hair cell target gene. Some embodiments of any of these methods can further include detecting a mutation in a hair cell target gene in a primate. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having non-syndromic sensorineural hearing loss. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having syndromic sensorineural hearing loss.

[0308] Also provided herein are methods of correcting a supporting cell target gene defect in a supporting cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the supporting cell target gene defect in the supporting cell of the inner ear of the primate.

[0309] Also provided herein are methods of increasing the expression level of a supporting cell target protein in a supporting cell of an inner ear of a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering results in an increase in the expression level of the supporting cell target protein in the supporting cell of the inner ear of the primate.

[0310] Also provided herein are methods of treating hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss) in a primate identified as having a defective supporting cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

[0311] Also provided herein are methods of restoring hearing in a primate identified or diagnosed as having hearing loss that include: administering to the inner ear of the primate a therapeutically effective amount of any compositions described herein.

[0312] Also provided herein are methods of restoring synapses and/or preserving spiral ganglion nerves in a primate identified or diagnosed as having an inner ear disorder that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

[0313] Also provided herein are methods that include administering to an inner ear of a primate a therapeutically effective amount of any of the compositions described herein.

[0314] In some embodiments of any of these methods, the primate has been previously identified as having a defective supporting cell target gene (e.g., a supporting cell target gene having a mutation that results in a decrease in the expression and/or activity of a supporting cell target protein encoded by the gene). Some embodiments of any of these methods further include, prior to the introducing or administering step, determining that the primate has a defective supporting cell target gene. Some embodiments of any of these methods can further include detecting a mutation in a supporting cell target gene in a primate. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having non-syndromic sensorineural hearing loss. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having syndromic sensorineural hearing loss.

[0315] In some embodiments of any of these methods, two or more doses of any of the compositions described herein are introduced or administered into the cochlea of the primate. Some embodiments of any of these methods can include introducing or administering a first dose of the composition into the cochlea of the primate, assessing hearing function of the primate following the introducing or the administering of the first dose, and administering an additional dose of the composition into the cochlea of the primate found not to have a hearing function within a normal range (e.g., as determined using any test for hearing known in the art).

[0316] In some embodiments of any of the methods described herein, the composition can be formulated for intra-cochlear administration. In some embodiments of any of the methods described herein, the compositions described herein can be administered via intra-cochlear administration or local administration. In some embodiments of any of the methods described herein, the compositions are administered through the use of a medical device (e.g., any of the exemplary medical devices described herein).

[0317] In some embodiments, intra-cochlear administration can be performed using any of the methods described herein or known in the art. For example, a composition can be administered or introduced into the cochlea using the following surgical technique: first using visualization with a 0 degree, 2.5-mm rigid endoscope, the external auditory canal is cleared and a round knife is used to sharply delineate an approximately 5-mm tympanomeatal flap. The tympanomeatal flap is then elevated and the middle ear is entered posteriorly. The chorda tympani nerve is identified and divided, and a currette is used to remove the scutal bone, exposing the round window membrane. To enhance apical distribution of the administered or introduced composition, a surgical laser may be used to make a small 2-mm fenestration in the oval window to allow for perilymph displacement during trans-round window membrane infusion of the composition. The microinfusion device is then primed and brought into the surgical field. The device is maneuvered to the round window, and the tip is seated within the bony round window overhang to allow for penetration of the membrane by the microneedle(s). The footpedal is engaged to allow for a measured, steady infusion of the composition. The device is then withdrawn and the round window and stapes foot plate are sealed with a gelfoam patch.

[0318] In some embodiments of any of the methods described herein, the primate has or is at risk of developing non-syndromic sensorineural hearing loss. In some embodiments of any of the methods described herein, the primate has been previously identified as having a mutation in a hair cell target gene. In some embodiments of any of the methods described herein, the primate has been previously identified as having a mutation in a supporting cell target gene. In some embodiments of any of the methods described herein, the primate has any of the mutations in a hair cell target gene that are described herein or are known in the art to be associated with non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss. In some embodiments of any of the methods described herein, the primate has any of the mutations in a supporting cell target gene that are described herein or are known in the art to be associated with non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss.

[0319] In some embodiments of any of the methods described herein, the primate has been identified as being a carrier of a mutation in a hair cell target gene (e.g., via genetic testing). In some embodiments of any of the methods described herein, the primate has been identified as being a carrier of a mutation in a supporting cell target gene (e.g., via genetic testing). In some embodiments of any of the methods described herein, the primate has been identified as having a mutation in a hair cell target gene and has been diagnosed with hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In some embodiments of any of the methods described herein, the primate has been identified as having a mutation in a supporting cell target gene and has been diagnosed with hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In some embodiments of any of the methods described herein, the primate has been identified as having hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In some embodiments, successful treatment of hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss) can be determined in a primate using any of the conventional functional hearing tests known in the art. Non-limiting examples of functional hearing tests are various types of audiometric assays (e.g., pure-tone testing, speech testing, test of the middle ear, auditory brainstem response, and otoacoustic emissions).

[0320] In some embodiments of these methods, the primate cell is in vitro. In some embodiments of these methods, the primate cell is originally obtained from a primate and is cultured ex vivo. In some embodiments, the primate cell has previously been determined to have a defective hair cell target gene. In some embodiments, the primate cell has previously been determined to have a defective supporting cell target gene.

[0321] Methods for introducing any of the compositions described herein into a primate cell are known in the art (e.g., via lipofection or through the use of a viral vector, e.g., any of the viral vectors described herein).

[0322] An increase in expression of an active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein) or an active hair cell target protein (e.g., a full-length hair cell target protein) as described herein is, e.g., as compared to a control or to the level of expression of an active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein) or an active hair cell target protein (e.g., a full-length hair cell target protein) prior to the introduction of the vector(s).

[0323] Methods of detecting expression and/or activity of a target protein (e.g., a supporting cell target protein or a hair cell target protein) are known in the art. In some embodiments, the level of expression of a hair cell target protein can be detected directly (e.g., detecting hair cell target protein or detecting hair cell target mRNA). In some embodiments, the level of expression of a supporting cell target protein can be detected directly (e.g., detecting supporting cell target protein or detecting supporting cell target mRNA). Non-limiting examples of techniques that can be used to detect expression and/or activity of a target protein (e.g., a supporting cell target protein or a hair cell target protein) directly include: real-time PCR, Western blotting, immunoprecipitation, immunohistochemistry, or immunofluorescence. In some embodiments, expression of a hair cell target protein can be detected indirectly (e.g., through functional hearing tests). In some embodiments, expression of a supporting cell target protein can be detected indirectly (e.g., through functional hearing tests).

Pharmaceutical Compositions and Kits

[0324] In some embodiments, any of the compositions described herein can further include one or more agents that promote the entry of a nucleic acid or any of the vectors described herein into a primate cell (e.g., a liposome or cationic lipid).

[0325] In some embodiments, any of the vectors described herein can be formulated using natural and/or synthetic polymers. Non-limiting examples of polymers that may be included in any of the compositions described herein can include, but are not limited to, DYNAMIC POLYCONJUGATE® (Arrowhead Research Corp., Pasadena, Calif.), formulations from Mirus Bio (Madison, Wis.) and Roche Madison (Madison, Wis.), PhaseRX polymer formulations such as, without limitation, SMARTT POLYMER TECHNOLOGY® (PhaseRX, Seattle, Wash.), DMRUDOPE, poloxamer, VAXFECTIN® adjuvant from Vical (San Diego, Calif.), chitosan, cyclodextrin from Calando Pharmaceuticals (Pasadena, Calif.), dendrimers and poly (lactic-co-glycolic acid) (PLGA) polymers, RONDEL™ (RNAi/Oligonucleotide Nanoparticle Delivery) polymers (Arrowhead Research Corporation, Pasadena, Calif.), and pH responsive co-block polymers, such as, but not limited to, those produced by PhaseRX (Seattle, Wash.). Many of these polymers have demonstrated efficacy in delivering oligonucleotides in vivo into a primate cell (see, e.g., deFougerolles, Human Gene Ther. 19:125-132, 2008; Rozema et al., Proc. Natl. Acad. Sci. U.S.A. 104:12982-12887, 2007; Rozema et al., Proc. Natl. Acad. Sci. U.S.A. 104:12982-12887, 2007; Hu-Lieskovan et al., Cancer Res. 65:8984-8982, 2005; Heidel et al., Proc. Natl. Acad. Sci. U.S.A. 104:5715-5721, 2007).

[0326] Any of the compositions described herein can be, e.g., a pharmaceutical composition. A pharmaceutical composition can include any of the compositions described herein and one or more pharmaceutically or physiologically acceptable carriers, diluents, or excipients. Such compositions may include one or more buffers, such as neutral-buffered saline, phosphate-buffered saline, and the like; one or more carbohydrates, such as glucose, mannose, sucrose, and dextran; mannitol; one or more proteins, polypeptides, or amino acids, such as glycine; one or more antioxidants; one or more chelating agents, such as EDTA or glutathione; and/or one or more preservatives.

[0327] In some embodiments, the composition includes a pharmaceutically acceptable carrier (e.g., phosphate buffered saline, saline, or bacteriostatic water). Upon formulation, solutions will be administered in a manner compatible with the dosage formulation and in such amount as is therapeutically effective. The formulations are easily administered in a variety of dosage forms such as injectable solutions, injectable gels, drug-release capsules, and the like.

[0328] As used herein, the term “pharmaceutically acceptable carrier” includes solvents, dispersion media, coatings, antibacterial agents, antifungal agents, and the like that are compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into any of the compositions described herein.

[0329] In some embodiments, a single dose of any of the compositions described herein can include a total sum amount of the at least two different vectors of at least 1 ng, at least 2 ng, at least 4 ng, about 6 ng, about 8 ng, at least 10 ng, at least 20 ng, at least 30 ng, at least 40 ng, at least 50 ng, at least 60 ng, at least 70 ng, at least 80 ng, at least 90 ng, at least 100 ng, at least 200 ng, at least 300 ng, at least 400 ng, at least 500 ng, at least 1 μg, at least 2 μg, at least 4 μg, at least 6 μg, at least 8 μg, at least 10 μg, at least 12 μg, at least 14 μg, at least 16 μg, at least 18 μg, at least 20 μg, at least 22 μg, at least 24 μg, at least 26 μg, at least 28 μg, at least 30 μg at least 32 μg, at least 34 μg, at least 36 μg, at least 38 μg, at least 40 μg, at least 42 μg, at least 44 μg, at least 46 μg, at least 48 μg, at least 50 μg, at least 52 μg, at least 54 μg, at least 56 μg, at least 58 μg, at least 60 μg, at least 62 μg, at least 64 μg, at least 66 μg, at least 68 μg, at least 70 μg, at least 72 μg, at least 74 μg, at least 76 μg, at least 78 μg, at least 80 μg, at least 82 μg, at least 84 μg, at least 86 μg, at least 88 μg, at least 90 μg, at least 92 μg, at least 94 μg, at least 96 μg, at least 98 μg, at least 100 μg, at least 102 μg, at least 104 μg, at least 106 μg, at least 108 μg, at least 110 μg, at least 112 μg, at least 114 μg, at least 116 μg, at least 118 μg, at least 120 μg, at least 122 μg, at least 124 μg, at least 126 μg, at least 128 μg, at least 130 μg at least 132 μg, at least 134 μg, at least 136 μg, at least 138 μg, at least 140 μg, at least 142 μg, at least 144 μg, at least 146 μg, at least 148 μg, at least 150 μg, at least 152 μg, at least 154 μg, at least 156 μg, at least 158 μg, at least 160 μg, at least 162 μg, at least 164 μg, at least 166 μg, at least 168 μg, at least 170 μg, at least 172 μg, at least 174 μg, at least 176 μg, at least 178 μg, at least 180 μg, at least 182 μg, at least 184 μg, at least 186 μg, at least 188 μg, at least 190 μg, at least 192 μg, at least 194 μg, at least 196 μg, at least 198 μg, or at least 200 μg, e.g., in a buffered solution.

[0330] The compositions provided herein can be, e.g., formulated to be compatible with their intended route of administration. A non-limiting example of an intended route of administration is local administration (e.g., intra-cochlear administration). In some embodiments, the therapeutic compositions are formulated to include a lipid nanoparticle. In some embodiments, the therapeutic compositions are formulated to include a polymeric nanoparticle. In some embodiments, the therapeutic compositions are formulated to include a mini-circle DNA. In some embodiments, the therapeutic compositions are formulated to comprise a CELiD DNA. In some embodiments, the therapeutic compositions are formulated to comprise a synthetic perilymph solution. An exemplary synthetic perilymph solution includes 20-200 mM NaCl; 1-5 mM KCl; 0.1-10 mM CaCl.sub.2; 1-10 mM glucose; 2-50 mM HEPES, having a pH of between about 6 and about 9.

[0331] Also provided are kits including any of the compositions described herein. In some embodiments, a kit can include a solid composition (e.g., a lyophilized composition including the at least two different vectors described herein) and a liquid for solubilizing the lyophilized composition. In some embodiments, a kit can include a pre-loaded syringe including any of the compositions described herein.

[0332] In some embodiments, the kit includes a vial comprising any of the compositions described herein (e.g., formulated as an aqueous composition, e.g., an aqueous pharmaceutical composition).

[0333] In some embodiments, the kits can include instructions for performing any of the methods described herein.

Devices and Surgical Methods

[0334] Provided herein are therapeutic delivery systems for treating hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In one aspect, the therapeutic delivery systems include i) a medical device capable of creating one or a plurality of incisions in a round window membrane of an inner ear of a primate in need thereof, and ii) an effective dose of a composition (e.g., any of the compositions described herein). In some embodiments, the medical device includes a plurality of micro-needles.

[0335] Also provided herein are surgical methods for treatment of hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In some embodiments, the methods include the steps of: introducing into a cochlea of a primate a first incision at a first incision point; and administering intra-cochlearly a therapeutically effective amount of any of the compositions provided herein. In some embodiments, the composition is administered to the primate at the first incision point. In some embodiments, the composition is administered to the primate into or through the first incision.

[0336] In some embodiments of any of the methods described herein, any of the compositions described herein is administered to the primate into or through the cochlea oval window membrane. In some embodiments of any of the methods described herein, any of the compositions described herein is administered to the primate into or through the cochlea round window membrane. In some embodiments of any of the methods described herein, the composition is administered using a medical device capable of creating a plurality of incisions in the round window membrane. In some embodiments, the medical device includes a plurality of micro-needles. In some embodiments, the medical device includes a plurality of micro-needles including a generally circular first aspect, where each micro-needle has a diameter of at least about 10 microns. In some embodiments, the medical device includes a base and/or a reservoir capable of holding the composition. In some embodiments, the medical device includes a plurality of hollow micro-needles individually including a lumen capable of transferring the composition. In some embodiments, the medical device includes a means for generating at least a partial vacuum.

[0337] The invention is further described in detail by reference to the following experimental examples. These examples are provided for purposes of illustration only, and are not intended to be limiting unless otherwise specified. Thus, the invention should in no way be construed as being limited to the following examples, but rather should be construed to encompass any and all variations that become evident as a result of the teaching provided herein.

[0338] Without further description, it is believed that one of ordinary skill in the art can, using the preceding description and the following illustrative examples, make and utilize the compounds of the present invention and practice the claimed methods. The following working examples specifically point out various aspects of the present invention, and are not to be construed as limiting in any way the remainder of the disclosure.

EXAMPLES

Example 1. AAV Single Vector Injection into the Inner Ear

[0339] Immunofluorescent staining was performed on cochlear tissue of a cynomolgus macaque (non-human primate) following administration of a single Anc80-GFP AAV vector directly into the inner ear through the round window.

[0340] The cochlear tissue from the treated macaque was processed for immunofluorescence analysis using Myo7a as a marker for hair cells and Iba-1 as a marker for macrophages. The middle turn is representative of the entire sensory epithelium. The data in FIGS. 1A-1C show clear GFP expression in both the hair cells and the supporting cells, including the following supporting cell subtypes: Hensen's cells (HC), Claudius cells (CC), Dieter cells (DC), inner and outer pillar cells (OPC/IPC), inner border cells, and inner phalangeal cells (IPHC/IBC). These data demonstrate successful Anc80-GFP AAV vector transduction into different cell types of the inner ear sensory epithelium, and the resulting expression of the encoded reporter gene (GFP) in these different cell types. These data indicate the present claimed compositions including a single AAV vector or two or more AAV vectors can be used to express a gene in hair cells and supporting cells, and can be used to repair a mutation in a gene in hair cells and supporting cells.

OTHER EMBODIMENTS

[0341] It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.

[0342] All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, section headings, the materials, methods, and examples are illustrative only and not intended to be limiting.