Composition and method of treating skin conditions

Abstract

The present invention is a composition and method of treatment for skin disorders, conditions, and severe skin dryness in general through topical systematic and periodic application of a formulation that generally may include salicylic acid, glycolic acid, urea, dimethyl isosorbide, ethoxydiglycol, barrier repair agents, anti-irritants, humectants, and also has an acidic pH formulation.

Claims

1. A composition for the treatment of dry skin consisting of a pharmaceutically effective amount of Ethoxydiglycol, Ally Methacrylates Crosspolymer, Salicylic Acid, Urea, Glycol Acid, Hexyldecanol, Bisabolol, Cetyl, Hydroxyproline Palmitate, Stearic Acid, Brassica Campestris Sterols, Glycine Soja Sterols, Saccharide Isomerate, Butylene Glycol, Pentylene Glycol, Hydroxyphenyl Propamidobenzoic Acid, and Niacinamide.

Description

DETAILED DESCRIPTION

(1) In a preferred embodiment, the composition generally comprises a composition and method of treatment for skin disorders and skin dryness through topical systematic and periodic application of a formulation. The formulation may be utilized as a cream, lotion, liquid, and combinations thereof. It is also understood that the following description of said components is not limited to exact percentages, quantities, or ingredients and that it is understood equivalent ingredients known in the art may be substituted or added. Due to the nature of skin disorders and skin dryness, a preferred embodiment of the invention provides a treatment that will generally penetrate and stay on the top two layers of skin.

(2) A Preferred Embodiment

(3) AHAs (alpha hydroxyl acids) promote cell renewal by weakening the bonds between neighboring skin cells, thus allowing them to be more easily shed. Unfortunately, keratolytic agents degrade keratin fibers that can accumulate and clog follicles. Utilizing a combination of Salicylic Acid, Glycolic Acid, and Urea will deliver an effective keratolytic effect, clear blockages, remove dead skin cells, and rid the skin of other cellular debris. To optimize the delivery and efficacy of these agents, the pH of the formulation will be acidic (to maintain the acids in their active form) and a penetration enhancer, Dimethyl Isosorbide, will be added. Lastly, the formulation will be rounded out by addition of barrier repair agents, anti-irritants, and humectants.

(4) In addition, the non-comedogenic emollients and humectants in a preferred embodiment of the invention bind moisture to the skin to provide long-lasting moisturization; free of fragrances, parabens, lanolin, and mineral oil. Helps restore and maintain the skin's natural protective barrier. A preferred embodiment of the invention provides a cream and or lotion that spreads easily and smoothly, absorbs rapidly, and never feels greasy. The invention may provide all-day moisturization with a single application and is clinically proven to increase skin hydration. It contains SKINMIMICS, a multi-lamellar concentrate of long chain ceramides, cholesterol, behenic acid, and sphingosine that demonstrates a reparative effect on the stratum corneum. Not only do its components reconstitute the skin barrier, but they also help to stimulate lipid synthesis and epidermal renewal. SKINMIMICS is designed for mature skin to help revitalize water management in the epidermisceramides, naturally occurring components of the skin that play a key role in enhancing and restoring the skin's protective function. It is contemplated the current invention may be part of a daily skin care routine specifically formulated for mature skin.

(5) The current invention contemplates a formulation as follows in TABLE 1. It is understood the current invention is not limited to same and the below is for illustrative purposes.

(6) TABLE-US-00001 TABLE 1 CONCENTRATION TRADE NAME INCI NAME (W/W) FUNCTION Miscellaneous QS to 100% Purified water, thickener, emollients, preservative, fragrance, pH adjuster, etc. Transcutol P Ethoxydiglycol 3% Penetration enhancer; optimizes the delivery of skin care actives; Polypore 450 SA Allyl Methacrylates 0.9% (0.45% Sal BHA; Keratolytic agent; delivery Crosspolymer (and) Acid) system helps to mitigate irritation Salicylic Acid Urea Urea 5% Keratolytic and moisturizing agent GlycolicAcid Glycolic Acid 10% AHA to promote cell turnover and renewal Symrepair Hexyldecanol (and) 3% Barrier repair and anti-inflammatory Bisabolol (and) Cetyl Hydroxyproline Palmitate (and) Stearic Acid (and) Brassica Campestris (Rapeseed) Sterols Generol 122 N Glycine Soja 0.75% Barrier repair, anti-inflammatory, and PRL Pentavitin (Soybean) Sterols improvements in skin elasticity Saccharide Isomerate 4% Humectant; substantive and durable hydrating effect; effective in low humidity environments; combats the drying effects of AHAs SymCalmin Butylene Glycol (and) 2% Anti-itch and anti-redness Pentylene Glycol (and) Hydroxyphenyl Propamidobenzoic Acid Niacinamide Niacinamide 0.5% Anti-oxidant anti-inflammatory, and barrier repair

(7) In another preferred embodiment, the current invention contemplates a formulation as follows in TABLE 2. It is understood the current invention is not limited to same and the below is for illustrative purposes.

(8) TABLE-US-00002 TABLE 2 CTFA Name Trade Name % (w/w) Purified Water Purified Water 38.250 Disodium EDTA Versene NA 0.100 Niacinamide Niacinamide 0.500 Urea Urea 5.000 Xanthan Gum (and) Acacia Senegal Solagum AX 1.000 Gum Glycerin USP Glycerin 1.000 Ethoxydiglycol Transcutol CG 3.000 Propylene Glycol Propylene Glycol 2.000 Salicylic Acid (and) Allyl Methacrylates Polypore 450 SA 0.900 Copolymer Glycolic Acid (and) Ammonium Glycolic 3.8 18.500 Glycolate Cetearyl Alcohol (and) Dicetyl Crodafos CES 2.000 Phosphate (and) Ceteth-10 Phosphate PEG-100 Stearate (and) Glyceryl Arlacel 165 3.000 Stearate Caprylic/Capric Triglycerides Neobee M5 5.000 Glycine Soja (Soybean) Sterols Generol 122 N PRL 0.250 Stearyl Alcohol Stearyl Alcohol 2.000 Dimethicone DC 200, 350 cst 3.000 Ceramide NP (and) Ceramide AP (and) SK Influx 2.000 Ceramide EOP (and) Phytosphingosine (and) Cholesterol (and) Sodium Lauroyl Lactylate (and) Carbomer (and) Xanthan Gum Saccharide Isomerate Pentavitin 4.000 Water (and) Glycerin (and) Avena DragoCalm 2.000 Sativa (Oat) Kernel Extract Phenoxyethanol (and) Euxyl PE 9010 1.000 Ethylhexylglycerin Acrylamide/Sodium Simulgel 600 4.000 Acryloyldimethyltaurate Copolymer (and) Isohexadecane (and) Polysorbate 80 Mica (and) Triethoxycaprylylsilane GMS-11SP 1.500 (and) Polyhydroxystearic Acid

(9) In yet another preferred embodiment, the current invention contemplates a formulation as follows in Table 3. It is understood the current invention is not limited to same and the below is for illustrative purposes.

(10) TABLE-US-00003 TABLE 3 CTFA Name Trade Name % (w/w) Purified Water Purified Water 38.150 Disodium EDTA Versene NA 0.100 Niacinamide Niacinamide 0.500 Urea Urea 5.000 Xanthan Gum (and) Acacia Senegal Gum Solagum AX 1.000 Glycerin USP Glycerin 1.000 Ethoxydiglycol Transcutol CG 3.000 Propylene Glycol Propylene Glycol 2.000 Salicylic Acid (and) Allyl Methacrylates Copolymer Polypore 450 SA 0.900 Glycolic Acid (and) Ammonium Glycolate Glycolic 3.8 18.500 Cetearyl Alcohol (and) Dicetyl Phosphate (and) Ceteth-10 Crodafos CES 2.000 Phosphate PEG-100 Stearate (and) Glyceryl Stearate Arlacel 165 3.000 Caprylic/Capric Triglycerides Neobee Al5 5.000 Glycine Soja (Soybean) Sterols Generol 122 N PRL 0.250 Stearyl Alcohol Stearyl Alcohol 2.000 Dimethicone DC 200, 350cst 3.000 Ceramide NP (and) Ceramide AP (and) Ceramide EOP (and) SK Influx 2.000 Phytosphingosine (and) Cholesterol (and) Sodium Lauroyl Lactylate (and) Carbomer (and) Xanthan Gum Saccharide Isomerate Pentavitin 4.000 Water (and) Glycerin (and) Avena Sativa (Oat) Kernel Extract DragoCalm 2.000 Phenoxyethanol (and) Ethylhexylglycerin Euxyl PE 9010 1.000 Acrylamide/Sodium Acryloyldimethyltaurate Copolymer (and) Simulgel 600 4.000 Isohexadecane (and) Polysorbate 80 Mica (and) Triethoxycaplylylsilane (and) GMS-11SP 1.500 Polyhydroxystearic Acid Biasabolol (and) Zingiber Officinale (Ginger) Root Extract Symrelief 100 0.100

(11) Formulation Summary

(12) As mentioned above, mature skin is often prone to hyperkeratotic conditions due to depressed cell renewal. Knees and elbows are typical sites of HP, whereas Keratosis Pilaris (KP) usually affects the back of the arms and front of the legs. This condition can be treated with alpha hydroxy acids (AHAs) and/or keratolytic agents, such as Urea and Salicylic Acid. AHAs promote cell renewal by weakening the bonds between neighboring skin cells, thus allowing them to be more easily shed. On the other hand, keratolytic agents degrade keratin fibers that can accumulate and clog follicles. Utilizing a combination of Salicylic Acid, Glycolic Acid, and Urea will deliver an effective keratolytic effect, clear blockages, remove dead skin cells, and rid the skin of other cellular debris. To optimize the delivery and efficacy of these agents, the pH of the formulation will be acidic to maintain the acids in their active form and a penetration enhancer, Ethoxydiglycol, will be added. Lastly, the formulation may be rounded out by addition of barrier repair agents, anti-irritants, and humectants.

(13) Keratolytic Agents

(14) Salicylic Acid has long been recognized as an effective keratolytic agent and is used to treat such conditions as acne, dandruff, and seborrheic dermatitis. By penetrating into the follicle, Salicylic Acid encourages the sloughing of dead skin cells and other cellular debris and, ultimately, clears blockages. Further benefits of its exfoliating action are improvements in skin texture and hyperpigmentation. This formulation utilizes Polypore 450 SA, an extended release delivery system. Salicylic Acid is loaded into a polymer matrix to allow slow, extended release of the active. This slow release allows for long- lasting availability of the active, as well as less irritation. Urea also contributes keratolytic action via degradation of keratin fibers. In addition, it helps to increase water content in the skin.

(15) Alpha-Hydroxy Acids

(16) Glycolic Acid has been widely used to enhance cell turnover rates. As the smallest alpha-hydroxy acid, it is believed to have the best penetration into the skin. By weakening the lipid bonds between cells, glycolic acid allows dead skin cells to shed from the skin surface. In addition, glycolic acid is has also been used to help reduce the appearance of wrinkles, acne scars, hyperpigmentation, and hyperkeratotic skin conditions.

(17) Barrier Repair/Humectancy

(18) Improvements in skin moisture levels are achieved via a barrier effect to prevent water from escaping the skin. Symrepair, a synergistic blend of ceramide, free fatty acids, and phytosterol reconstitute and repair the skin barrier. Bisabolol, the active fraction of chamomile and a potent anti-inflammatory agent, is also a component of the blend and can help mitigate the irritating effects of hydroxy acids. Pure Soybean Sterols, a class of phytosterols, share a similar structure to that of cholesterol, an important component of the skin's lipid barrier. Aside from strengthening and repairing the skin barrier, phytosterols also have leucotriene inhibiting properties to deliver an anti-inflammatory effect. Soybean Sterols exhibit good penetration to provide emolliency and improve skin elasticity. Lastly, Saccharide Isomerate, engages in specializing binding with keratin fibers, allowing the carbohydrate to attract water while demonstrating high substantivity and resistance to wash-off. The combination of these barrier repair agents and humectants will help repair and reinforce the skin barrier, as well as offer a long-lasting moisturization effect.

(19) Anti-irritants

(20) Hydroxy acids are typically associated with irritation, since their cell renewal and/or keratolytic effects occur under acidic conditions. The irritation and redness commonly associated with hydroxy acid use can be reduced by addition of anti-irritants. The previously mentioned Soybean Sterols and Bisabolol function to calm irritation and inflammation. In addition, another skin benefit of Saccharide Isomerate is its ability to help decrease the dryness and irritation associated with AHAs. SymCalmin, containing avenathramides, exhibits potent anti-histamine activity to calm itch and reduce redness. Lastly, Niacinamide (Vitamin B3) contributes anti-inflammatory and anti-oxidant activity, as well as improves barrier function via stimulation of ceramide production.

(21) A number of implementations have been described herein. Nevertheless, it will be understood that various modifications may be made. Accordingly, other implementations are within the scope of the following claims. Changes may be made in the combinations, operations, and arrangements of the various parts, elements, and amounts described herein without departing from the spirit and scope of the invention.