Method of Marking Film-Like Dosage Forms

Abstract

Disclosed is a method for marking film-type dosage forms, comprising at least the positioning of a film-type dosage form between two layers of a scalable packaging material, the sectional heat-scaling of the two layers of the scalable packaging material so as to obtain an edge-sealed bag containing the film-type dosage form, and the blind-embossing of the film-type dosage form contained in the edge-sealed bag through at least one of the two layers of packaging material of the edge-sealed bag.

Claims

1. A method of marking film-type dosage forms including at least the following steps: placing a film-type dosage form between two layers of sealable packaging material; sectionally heat sealing the two layers of the sealable packaging material to form an edge-sealed bag containing the film-type dosage form; and blind embossing the film-type dosage form contained in the edge-sealed bag through at least one of the two packaging material layers of the edge-sealed bag.

2. The method as claimed in claim 1; wherein the two layers of sealable packaging material are provided in the form of a strip-shaped rolled product.

3. The method as claimed in claim 1; wherein the blind embossing is effected with a pressure of at least 2 bar and not more than 10 bar.

4. The method as claimed in claim 1; wherein the embossing tools used for the blind embossing are cooled.

5. The method as claimed in claim 1, wherein the blind embossing is flat embossing or relief embossing.

6. The method as claimed in claim 1; wherein the blind embossing is effected with at least one embossing tool selected from the group consisting of embossing stamps, embossing wheels, and embossing rollers.

7. The method as claimed in claim 1; wherein the blind embossing forms at least one mark on the film-type dosage form selected from the group consisting of numbers, letters, symbols, shapes, and combinations thereof.

8. The method as claimed in claim 1, further comprising: sectionally heat sealing the two layers of the sealable packaging material to form a second edge-sealed bag containing a second film-type dosage form; and separating the edge-sealed bag from the second edge-sealed bag.

9. The method as claimed in claim 8; wherein the edge sealed bag is separated from the second edge-sealed bag before the blind embossing.

10. A film-like dosage form comprising: an embossed marking formed according to the method as claimed in claim 1.

11. The film-like dosage form as claimed in claim 10; wherein the film-like dosage form is present in an edge-sealed bag.

12. The film-like dosage form as claimed claim 10; wherein the film-like dosage form is a heavy oily film.

13. The method as claimed in claim 8; wherein the edge-sealed bag is separated from the second edge-sealed bag after the blind embossing.

Description

EXEMPLARY EMBODIMENT

[0048] A film, which rapidly dissolves in the oral cavity, based on a copolymer of methacrylic acid and ethyl acetate (1:1) (Eudragit L 100-55 from the company Evonik Nutrition Care GmbH) containing 2.5 mg nicotine and 6.64 mg mint oil was subjected to blind embossing in which an embossing stamp pressed a two digit number about 8 mm high with a pressure of 2 bar into the film. After sealing into two layers of aluminium foil laminated with sealable plastic material the marked films were stored at room temperature without being pressed. After a storage period of at most four weeks no embossing was visible on the unpacked films.

[0049] In parallel with the aforementioned control experiment, the same films were firstly sealed in the same packaging material and then subjected to blind embossing in which an embossing stamp pressed a two digit number about 8 mm high with a pressure of 2 bar into the film through one layer of packaging material. After storing for more than half a year, no change in the marking of the films in comparison with an identical marking directly after embossing could be detected.