VACUUM DISTILLATION FOR ENRICHING CANNABIDIOL

Abstract

The present invention relates to a method for producing, obtaining and enriching cannabidiol (CBD) and to the use thereof. The invention also relates to a cannabidiol extract and the use of an obtained cannabidiol extract in the pharmaceutical and cosmetic fields.

Claims

1.-15. (canceled)

16. A method for extracting cannabidiol from cannabis plant material, which comprises a vacuum distillation by means of a rectifying column is performed, wherein the vacuum distillation is performed on a primary extract with at least 15% by weight cannabidiol, wherein the pressure is 0.001 to 50 mbar and the temperature is 120 to 240 C., and an enrichment of cannabidiol of more than 70% by weight in the dry weight of an extract is achieved, with depletion of THC.

17. The method for extracting cannabidiol from cannabis plant material according to claim 16, wherein the vacuum distillation is a short-path distillation.

18. The method for extracting cannabidiol from cannabis plant material according to claim 16, wherein the vacuum distillation is performed by means of a thin-film evaporator, short-path evaporator or falling film evaporator.

19. The method for extracting cannabidiol from cannabis plant material according to claim 18, wherein the length of the rectifying column is at least 2.50 m.

20. The method for extracting cannabidiol from cannabis plant material according to claim 16, wherein the pressure is 0.001 to 10 mbar and the temperature is 150 to 240 degrees Celsius.

21. The method for extracting cannabidiol from cannabis plant material according to claim 16, wherein the vacuum distillation is coupled with a column distillation.

22. A cannabidiol-containing extract obtained by the method according to claim 16, having a CBD:THC ratio of at least 125:1.

23. The cannabidiol-containing extract according to claim 22, having a CBD:CBN ratio of at least 384:1.

24. The cannabidiol-containing extract according to claim 21, wherein the extract has the capability of residue-free vaporisation.

25. A pharmaceutical product containing a cannabidiol-containing extract for use in inhalation obtained by the method according to claim 16.

26. A cosmetic or dietary supplement which comprises the cannabidiol-containing extract according to claim 22.

Description

[0041] The invention therefore also relates to a cannabidiol-containing extract obtainable by a method according to the invention having a high-boiling proportion of less than 5% based on CBD and a low-boiling proportion of less than 7% based on CBD.

[0042] FIG. 1 shows an HPLC chromatogram of an extract of this kind obtained from column distillation under vacuum.

[0043] Furthermore, an exemplary starting composition was used as follows for the method according the invention, with a starting ratio of approximately 45:1:

TABLE-US-00002 Cannabidiol (CBD) % 23.8 Delta9-THC % 0.53 C3-cannabidiol % 0.71 C4-cannabidiol % 0.13 CBN % 0.71

[0044] Furthermore, the low-boiling proportion based on CBD [%] is 19.8, and the high-boiling proportion based on CBD [%] is 26.0.

[0045] The method according to the invention particularly advantageously allows a significant reduction of the low- and high-boiling proportions compared to a used starting material. This leads to an extract having specific properties, such as the advantageous capability, of residue-free vaporisation which is particularly suitable for inhalation of CBI) in a medical application, in particular for a pharmaceutical product.

[0046] This enriched cannabidiol-containing extract, on account of its excellent consistency, can be used immediately particularly advantageously in formulations such as ointments, creams, gels, lotions (body milk), pastes or preferably emulsions.

[0047] The invention therefore also relates to a pharmaceutical product, dietary supplement or cosmetic containing a cannabidiol-containing extract obtainable by a method according to the invention. The pharmaceutical product is particularly suitable for antispastic, analgesic, antiemetic, neuroprotective, anti-inflammatory effect and in psychiatric illnesses.

[0048] A pharmaceutical composition or agent according to the invention, in particular a pharmaceutical product (medicament), can be galenically prepared in the usual manner. Suitable solid or liquid galenic preparation forms are, for example, granules, powder, lozenges, tablets, (micro)capsules, hard capsules, suppositories, syrups, juices, pensions, or emulsions, in the production of which conventional auxiliaries such as carriers, disintegrants, binders, coating agents, swelling agents, lubricants, flavourings, sweeteners and solubilisers are used. Potential auxiliary substances are magnesium stearate, sodium chloride, magnesium carbonate, titanium dioxide, lactose, mannitol and other sugars, talc, milk protein, gelatins, starches, celluloses and derivatives thereof, animal and vegetable oils, such as cod liver oil, sunflower oil, groundnut oil or sesame oil, polyethylene glycols, and solvents, such as sterile water and mono- or polyvalent alcohols, for example glycerol

[0049] Further detergents and surfactants can also be provided as auxiliaries and additives, as will be mentioned hereinafter by way of example for a cosmetic composition.

[0050] Emulsions, in particular for a cosmetic composition, are understood generally to mean heterogeneous systems consisting of two liquids that are not miscible with one another or that are only miscible with one another to a limited extent and which are usually referred to as phases. In an emulsion, one of the two liquids is dispersed in the form of very fine droplets within the other liquid. If the two liquids are water and oil and oil droplets are finely distributed in water, this is an oil-in-water emulsion (O/W emulsion). The basic character of an O/W emulsion is defined by the water. In the case of a water-in-oil emulsion. (W/O emulsion), the principle is reversed and the basic character is determined here by the oil. Mixed systems, such as water-in-oil-in-water emulsions (W/O/W emotions) and oil-in-water-in-oil emulsions (O/W/O emotions) are also known. All specified emulsions are suitable in accordance with the invention.

[0051] The anhydrous systems suitable in accordance with the invention include pure oil preparations, such as skin oils. Pastes containing the preparation according to the invention can also be used and are characterised in that they consist of the same or similar constituents as an emulsion, but are substantially anhydrous. Within the scope of the present invention, the terms oil phase and lipid phase are used synonymously. In a further preferred embodiment the preparation according to the invention can contain an emulsifier as a further constituent. In a very preferred embodiment this emulsifier can be an O/W emulsifier.

[0052] Emulsifiers can be selected advantageously from the group of non-ionic, anionic, cationic or amphoteric emulsifiers.

[0053] Various emulsifiers from the groups of partial fatty acid esters, fatty alcohols, sterols, polyethylene glycols such as ethoxylated fatty acids, ethoxylated fatty alcohols and ethoxylated sorbitan esters, sugar emulsifiers, polyglycerol emulsifiers or silicone emulsifiers can be used as non-ionic emulsifier.

[0054] Various emulsifiers from the groups of soaps, for example, sodium stearate, fatty alcohol sulphate, mono-, di- and trialkyl phosphoric esters and ethoxylates thereof, fatty acid lactate esters, fatty acid citrate esters, or fatty acid citroglycerol esters can be used as anionic emulsifiers.

[0055] For example, quaternary ammonium compounds with a long-chain aliphatic group, for example distearyldimonium chlorides, can be used as cationic emulsifiers.

[0056] Various emulsifiers from the groups alkylamininoalkane carboxylic acids, betaines, sulfobetaines or imidazoline derivatives can be used as amphoteric emulsifiers.

[0057] Naturally occurring emulsifiers, for example including beeswax, lanolin wax, lecithin and sterols, amongst others, which can likewise be used in the production of a preparation according to the invention are preferred in accordance with the invention. In a preferred formulation of the preparation according to the invention, O/W emulsifiers can be selected from the group of plant protein hydrolysates and derivatives thereof.

[0058] In the sense of the present invention, substances selected from the group of esters of saturated and/or unsaturated, branched and/or unbranched alkane carboxylic acids and/or alkene carboxylic acids with a chain length of 3-30 carbon atoms and saturated and/or unsaturated, branched and/or unbranched alcohols with a chain length of 3-30 carbon atoms and from the group of esters of aromatic carboxylic acids and saturated and/or unsaturated, branched and/or unbranched alcohols with a chain length of 3 to 30 carbon atoms can also be contained advantageously as additives. Esterols of this kind can then be selected advantageously from the group of isopropylmyristate, isopropylpalmitate, isopropylstearate, isopropyloleate, n-butylstearate, n-hexyllaurate, n-decyloleate, isooctylstearate, isononylstearate, isononyliso-nonanoate, 2-ethylhexylpalmitate, 2-ethylhexyllaurat, 2-hexyldecylstearate, 2-octyldodecyl-palmitate, oleyloleate, oleylerucate, erucyloleate, erucylerucate and synthetic, semisynthetic and natural mixtures of such esters, such as jojoba oil.

[0059] The oil phase can also be selected advantageously from the group of branched and unbranched hydrocarbons and waxes, dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides, specifically triglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkane carboxylic acids with a chain length of 8-24 carbon atoms, in particular 12-18 carbon atoms. The fatty acid triglycerides can be selected advantageously for example from the group of synthetic, semisynthetic and natural oils.

[0060] In particular, antioxidants and/or radical catchers can be added additionally as auxiliary or additive to the preparations according to the invention, Antioxidants of this kind are advantageously selected from the group of lipophilic systems, for example: natural and synthetic tocopherols, nordihydroguaiaretic acid, coniferyl benzoate, butylhydroxyanisole, butylhydroxytoluene, gallic acid ester, and various antioxidant plant extracts. From the hydrophilic systems, inorganic sulphur compounds, sodium hydrogen sulphite, cysteine, or ascorbic acid can be used particularly advantageously.

[0061] The cosmetic preparations according to the invention can also contain cosmetic auxiliaries, as are used conventionally in preparations of this kind, for example preservatives, bactericides, perfumes, substances for preventing foaming, dyes, pigments which have a colouring effect, thickeners, surface-active substances, softening, dampening and/or moistening substances, or other conventional constituents of a cosmetic or dermatological formulation, such as alcohols, polyols, polymers, foam stabilisers, electrolytes, organic solvents or silicone derivatives.

[0062] In a further particular embodiment, the preparation according to the invention is composed of substantially naturally occurring ingredients, as mentioned above.