Composition for preventing or treating scars

Abstract

The present invention relates to a composition for preventing or treating scars and a preparation method therefor. The composition, according to one aspect, comprises a pigment and silicone oil, and may be stably formulated into a formulation adequate for spreading on the skin, and may inhibit the formation of scars or reduce already existing scars by forming a membrane on the skin, and has an effect whereby scars may be concealed by the pigment stably dispersed in the composition.

Claims

1. A method for preparing a skin external composition, the method comprising: obtaining a first phase including a first silicone oil; obtaining a second phase comprising a second silicone oil and a pigment by mixing and dispersing the second silicone oil and the pigment, wherein the second silicone oil is distinct from the first silicone oil of the first phase; and mixing and dispersing the first phase and the second phase, wherein the silicone oils of the first and second phases include at least one selected from the group consisting of dimethicone, polysilicone-11, hydrogen dimethicone, cyclopentasiloxane and cyclohexasiloxane, wherein an amount of the total silicone oil of the first and second phases is in a range of 70% by weight to 85% by weight based on a total weight of the skin external composition, wherein the pigment includes at least one selected from the group consisting of titanium dioxide, zinc oxide, iron oxide and aluminum hydroxide, wherein an amount of the pigment is in a range of 10% by weight to 19% by weight based on a total weight of the skin external composition, and wherein the mixing and dispersing of the first and second phase is performed by a milling process.

Description

DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is a photograph showing spreadability evaluation on compositions of comparative example 2 and comparative example 3 according to one embodiment.

(2) FIG. 2 is a photograph showing scar removal evaluation on compositions of comparative example 1, comparative example 3, and example 1 according to one embodiment.

(3) FIG. 3 is a photograph showing scar removal evaluation on compositions of comparative example 4 and example 1 according to one embodiment.

BEST MODE

(4) Hereinafter, the embodiments of the present invention will be described in more detail by using examples. However, these examples are intended to illustrate one or more embodiments, but the scope of the present invention is not limited thereto.

Example 1 and Comparative Examples 1 to 4: Preparation of Composition for Prevention or Treatment of Scars

(5) In order to prepare a composition for the prevention or treatment of scars the followings were performed. First, components of phase-A of Table 1 below were mixed at room temperature. Next, after mixing components of phase-B of Table 1, full dispersion was carried out using a three-stage roller (Kyoung Yong Machinery Co., Ltd.). After mixing phase-A with phase-B prepared as described above, full dispersion was carried out using the three-stage roller at room temperature, and thus the composition for prevention or treatment of the scars was prepared.

(6) Specific components and contents of Example 1 and Comparative Examples 1 to 4 are shown in Table 1 below. Unless stated otherwise in the specification herein, content of each component is indicated as a weight percent.

(7) TABLE-US-00001 TABLE 1 Comparative Comparative Comparative Comparative Phase Component Example 1 Example 2 Example 3 Example 4 Example 1 A Dimethicone 44.5275 40.4775 38.2275 31.4775 31.4775 Polysilicon-11 14.8425 13.4925 12.7425 10.4925 10.4925 Cyclopentasiloxane 39.58 35.98 33.98 27.98 27.98 Total 98.95 89.95 84.95 69.95 69.95 B Titanium dioxide 0.6435 6.435 6.435 12.87 12.87 Zinc oxide 0.18 1.8 1.8 3.6 3.6 Iron oxide (CI 0.0648 0.648 0.648 1.296 0.696 77492) Hydrogen 0.035 0.35 0.35 0.7 0.7 dimethicone Iron oxide (CI 0.0276 0.276 0.276 0.552 0.324 77491) Iron oxide (CI 0.027 0.27 0.27 0.54 0.264 77499) Aluminum 0.165 0.165 0.33 0.33 hydroxide 0.0165 Diphenylsiloxyphenyltrimethicone 0.00374 0.0374 0.0374 0.0748 0.04 Triethoxysilylethylpolydimethyl- 0.00124 0.0124 0.0124 0.0248 0.0136 siloxyethylhexyldimethicone Bariumsulphate 0.00061 0.0061 0.0061 0.0122 1.1392 Dimethicone 0.00001 0.0001 0.0001 0.0002 0.0232 Cyclopentasiloxane — — 3.2 6.4 6.4 Cyclopentasiloxane — — 1.8 3.6 3.6 Tocopheryl acetate 0.05 0.05 0.05 0.05 0.05 Total 1.05 10.05 15.05 30.05 30.05 Total 100 100 100 100 100

Experimental Example 1: Evaluation on Spreadability

(8) In order to evaluate spreadability, compositions of Comparative Example 2 and Comparative Example 3 were evaluated by taking out the compositions with the same amount and applying the compositions onto a flat paper with the same force. FIG. 1 shows the spreadability evaluation result.

(9) As shown in FIG. 1, it was confirmed that the composition of Comparative Example 3 has the excellent applicability and spreadability, because the composition of Comparative Example 3 was uniformly applied without clumping or agglomeration compared to the composition of Comparative Example 2.

(10) Accordingly, it was confirmed that even when content of the silicone oil contained in the whole composition is the same, the pigment is dispersed in the composition stably and uniformly due to a process of dispersing the pigment into appropriate amounts of silicone oil by the milling process and then mixing the dispersion with remaining silicone oil, so that formulation becomes stable, the applicability and spreadability are improved, and the formulation is suitable to be applied to the skin.

Experimental Example 2: Evaluation on Scar Removability

(11) In order to evaluate scar removability by concealing the scar, the same red marks were marked on one person's arm with a red pen; the same amount of the compositions of Comparative Example 1, Comparative Example 3, and Example 1 was applied to the marked portions or no composition was applied (control group); and the degree of removal of the red marks was checked. The resulted photographs are shown in FIG. 2.

(12) As shown in FIG. 2, it was confirmed that the removal degrees of the red marks were excellent in a sequence of Comparative Example 1, Comparative Example 3, and Example 1.

(13) Accordingly, it was confirmed that the composition of Example 1 contains the pigment so that the effect of concealing and removing the scar is excellent when applied to the skin.

Experimental Example 3: Evaluation on Scar Removability

(14) FIG. 3 shows photographs confirming the scar removability with application of the compositions of Comparative Example 4 and Example 1 or without application (control group), in the same manner as in Experiment Example 2.

(15) As shown in FIG. 3, it was confirmed that the red mark appeared darkening when the composition of Comparative Example 4 is applied. In contrast, it was confirmed that the red mark was concealed properly and almost invisible as a result of the application of Example 1, and the pigment was deposited and thus became invisible.

(16) Accordingly, it was confirmed that, because the skin looks black due to pigment when the pigment in the composition of Example 1 is excessively used, the composition of Example 1 using an appropriate amount of pigment has the excellent effect of scar removal and concealment.

Experimental Example 4: Evaluation on Scar Treatment Effect

(17) In order to evaluate the scar treatment effect, the same scars were made on five mice, and sizes of the scars were measured. The compositions of Example 1, Comparative Examples 1 to 4 were applied to the scar sites once every three days for two months. The results of evaluating the scar treatment effect are shown in Table 2 below, in which sizes of the scars were measured after 2 months, and the scar size after application is calculated as a percentage of the scar size before application.

(18) TABLE-US-00002 TABLE 2 Comparative Comparative Comparative Comparative Exam- Example 1 Example 2 Example 3 Example 4 ple 1 Scar 10% 12% 11% 12% 10% size

(19) As shown in Table 2, it was confirmed that the scars were reduced to about 10% within two months after applying the compositions of Comparative Examples 1 to 4 and Example 1. Accordingly, it was confirmed to exhibit an excellent scar healing effect when the compositions of Comparative Examples 1 to 4, and Example 1 include the silicone oil.