CATALYTIC SYNTHESIS OF FREE ISOCYANATES

Abstract

The present invention is directed towards a process for the preparation of free isocyanates, which improves upon the disadvantages associated with heterogeneous catalysis. The process comprises converting formamides into the corresponding isocyanates via a catalytic dehydrogenation, which involves bringing the formamide into contact with a Group VII, VIII or IX transition metal complex and heating.

Claims

1. A process for preparing free isocyanate, the process comprising converting a formamide into a corresponding free isocyanate by catalytic dehydrogenation, wherein: the formamide is contacted with a catalyst and heated to a temperature of 160-240? C., the process is a homogenous catalytic process, the free isocyanate is a monoisocyanate, a diisocyanate, or a polyisocyanate, the conversion of the formamide to the corresponding isocyanate takes place in a solvent, and the catalyst is a transition metal complex of the formula: ##STR00016## wherein: M is Ru; each X, Y and Z are independently P, N, or C; each R.sub.6 and R.sub.7 are independently Ph.sub.2, (iPr).sub.2, (tBu).sub.2 or Et.sub.2; each R.sub.8 and R.sub.9 are independently H, a C1-C10 alkyl, or a C5-C10 aryl; each R.sub.10 and R.sub.11 are independently H, a C1-C10 alkyl, or a C5-C10 aryl; each m and n are independently an integer of 0-3; p is 0 or 1; and when p is 1, R.sub.12 is Cl; wherein optionally: the carbon attached to R.sub.8 forms a double bond with the carbon attached to R.sub.9; and/or the carbon attached to R.sub.10 forms a double bond with the carbon attached to R.sub.11; and/or two or more of R.sub.8, R.sub.9, R.sub.10, and R.sub.11 form a ring system; and/or the carbon attached to R.sub.9 forms a double bond with Y; and/or the carbon attached to R.sub.10 forms a double bond with Y.

2. The process according to claim 1, wherein hydrogen is released.

3. The process according to claim 1, wherein the catalytic dehydrogenation is a non-oxidative catalytic dehydrogenation.

4. The process according to claim 1, wherein the formamide is a secondary amide.

5. The process according to claim 1, wherein the free isocyanate is a monoisocyanate of the formula:
R.sub.1(CH.sub.2).sub.wNCO, wherein: R1 is a C1-C4 linear or branched alkyl, or a C5-C10 aryl; and w is an integer of 0-3.

6. The process according to claim 1, wherein the free isocyanate is a diisocyanate.

7. The process according to claim 6, wherein the free isocyanate is a diisocyanate of the formula:
OCN(R.sub.2).sub.x(R.sub.4).sub.a(CH.sub.2).sub.z(R.sub.5).sub.b(R.sub.3).sub.yNCO, wherein: each R.sub.2 and R.sub.3 are independently CH.sub.2, CH(CH.sub.3) or C(CH.sub.3).sub.2; each x and y are independently an integer of 0-5; each R.sub.4 and R.sub.5 are independently a C3-C8 cyclic alkylene or C5-C10 arylene, each optionally substituted with one or more CH.sub.3 groups; each a and b are independently an integer of 0 or 1; and z is an integer of 0-2.

8. The process according to claim 7, wherein the diisocyanate is H12MDI, HDI, IPDI, 4,4-MDI, 2,4-MDI, 2,2-MDI, m-XDI, p-XDI, m-TMXDI, p-TMXDI, NDI, 2,4-TDI or 2,6-TDI.

9. The process according to claim 1, wherein the formamide is heated to a temperature of 170-240? C.

10. The process according to claim 1, wherein the solvent is an aprotic solvent.

11. The process according to claim 10, wherein the aprotic solvent is an aromatic hydrocarbon or an ether.

12. The process according to claim 1, wherein the process takes place under inert atmosphere.

13. The process according to claim 1, wherein the conversion of the formamide to the corresponding free isocyanate takes place in the presence of an additive.

14. The process according to claim 13, wherein the additive is a base, an acid, or a hydrogen scavenger.

15. The process according to claim 13, wherein the additive is DBU, DBN, DABCO, or an alkylamine.

16. The process according to claim 13, wherein the additive is p-TsOH.

17. The process according to claim 13, wherein the additive is an olefin.

18. The process according to claim 1, wherein the transition metal complex is ##STR00017##

19. The process according to claim 11, wherein the aprotic solvent is toluene, dioxane or cyclopentyl methyl ether.

20. The process according to claim 17, wherein the additive is 3,3-dimethylbutene.

21. The process according to claim 1, wherein two or more of R.sub.8, R.sub.9, R.sub.10, and R.sub.11 form an aromatic C3-C6 monocyclic ring system.

22. The process according to claim 1, two or more of R.sub.8, R.sub.9, R.sub.10, and R.sub.11 form an aromatic C9-14 tricyclic ring system.

Description

DETAILED DESCRIPTION

[0015] Embodiments according to the present invention will now be described in more detail.

[0016] As used herein, Ph refers to a phenyl group, .sup.iPr refers to an iso-propyl group, .sup.tBu refers to a tert-butyl group and Et refers to an ethyl group.

[0017] As used herein, the term free isocyanate refers to the isocyanate which corresponds to the formamide starting material (see figure below). The free isocyanate is not bound, in particular not covalently bound, or complexed to any additional elements or compounds (such as the catalyst).

##STR00001##

[0018] The term pincer ligand refers to a tridentate ligand. Examples of pincer ligands include, but are not limited to the following:

##STR00002##

[0019] Pincer ligands can be labelled by naming them according to the atoms interacting with the metal centre, such that the first compound in the above figure is referred to as a PNN-type pincer ligand and the second compound is referred to as a PNP-type pincer ligand.

[0020] The term non-innocent ligand refers to a ligand which can take part in a reaction to be catalysed by a transition metal catalyst comprising the non-innocent ligand. For example, a non-innocent ligand could undergo a deprotonation during the reaction, forming a basic site on the ligand which has the ability to abstract a proton from the substrate. A non-innocent redox-ligand, for example, could function as an electron reservoir, such that the oxidation state of the metal does not change during the catalytic cycle.

[0021] The reaction according to the invention is a catalytic dehydrogenation of formamides to isocyanates (see figure below). Throughout the reaction, free isocyanate, i.e., isocyanate that is not covalently bonded to any additional elements or compounds, is released and the transition metal catalyst is regenerated. It was generally confirmed by High-Resolution Mass Spectrometry (HRMS) that the free isocyanate was obtained. The free isocyanate can be isolated and characterised utilising suitable methods.

##STR00003##

[0022] A process according to the present invention includes converting a formamide into the corresponding isocyanate by catalytic dehydrogenation, wherein the formamide is brought into contact with a catalyst and is heated, wherein the catalyst is a Group VII, VIII or IX transition metal complex.

[0023] In a preferred embodiment, the formamide is a secondary amide.

[0024] The process according to the invention can be used for the preparation of free isocyanate, wherein the isocyanate can be a monoisocyanate, a diisocyanate, or a polyisocyanate.

[0025] When the isocyanate is a monoisocyanate, the monoisocyanate is preferably of the formula [0026] R.sub.1(CH.sub.2).sub.wNCO, wherein: [0027] R.sub.1 is a C1-C4 linear or branched alkyl, or a C5-C10 aryl; and [0028] w is an integer of 0-3; [0029] preferably R.sub.1 is phenyl or tert-butyl, and w is an integer of 0-3.

[0030] The corresponding formamide can, for example be

##STR00004##

[0031] When the isocyanate is a monoisocyanate, the monoisocyanate is more preferably butylisocyanate.

[0032] preferred embodiment, the free isocyanate is a diisocyanate.

[0033] When the isocyanate is a diisocyanate, the diisocyanate is preferably of the formula [0034] OCN(R.sub.2).sub.x(R.sub.4).sub.a(CH.sub.2).sub.z(R.sub.5).sub.b(R.sub.3).sub.yNCO, wherein: [0035] each R.sub.2 and R.sub.3 are independently CH.sub.2, CH(CH.sub.3) or C(CH.sub.3).sub.2; [0036] each x and y are independently an integer of 0-5; [0037] each R.sub.4 and R.sub.5 are independently a C3-C8 cyclic alkylene or C5-C10 arylene, each optionally substituted with one or more CH.sub.3 groups; [0038] each a and b are independently an integer of 0 or 1; [0039] and z is an integer of 0-2.

[0040] When the isocyanate is a diisocyanate, the diisocyanate is more preferably hydrogenated MDI (also known as 4,4-diisocyanato dicyclohexylmethane or bis (4-isocyanatocyclohexyl) methane) (H12MDI), hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), 4,4-methylene diphenyl diisocyanate (MDI), 2,4-MDI, 2,2-MDI, m-xylylene diisocyanate (m-XDI), p-xylylene diisocyanate (p-XDI), m-tetramethylxylene diisocyanate (m-TMXDI), p-tetramethylxylene diisocyanate (p-TMXDI), 1,5-naphthylene diisocyanate (NDI), 2,4-toluene diisocyanate (2,4-TDI), or 2,6-toluene diisocyanate (2,6-TDI).

##STR00005## ##STR00006##

[0041] Most preferably the diisocyanate is HDI, H12MDI or 2,4-TDI.

[0042] In a preferred embodiment according to the present invention, a process for the preparation of free isocyanate is a homogeneous catalytic process.

[0043] According to a preferred embodiment of the invention, the process comprises the release of hydrogen.

[0044] In a further preferred embodiment, the catalytic dehydrogenation is a non-oxidative catalytic dehydrogenation.

[0045] In a preferred embodiment, the process takes place under inert atmosphere.

[0046] According to a preferred embodiment of the invention, when the formamide is brought into contact with a catalyst and is heated, the temperature is preferably between 100-250? C. More preferably the temperature is between 160-240? C., even more preferably between 165-240? C., even more preferably between 170-240? C., even more preferably between 175-235? C., even more preferably between 180-230? C., even more preferably between 185-225? C. Most preferably, the temperature is between 190-220? C.

[0047] The process according to the invention can be carried out in any means suitable, preferably in an autoclave reactor or a microwave. Based on the knowledge of the micro kinetics of the reaction, the skilled person would use suitable reactor types.

[0048] In a preferred embodiment, the formamide and the catalyst are heated, preferably at a temperature of between 190-220? C., for between 0.5-48 hours, more preferably 1-36 hours, even more preferably 1-24 hours, even more preferably 1-16 hours, even more preferably 1-12 hours, even more preferably 1-8 hours, most preferably 1-4 hours.

[0049] The process according to the invention can be carried out in neat conditions or in the presence of one or more solvents. In a preferred embodiment, the conversion of the formamide to the corresponding isocyanate takes place in a solvent. Preferably, the solvent is an aprotic solvent. This has the advantage that it avoids the conversion of the product into unwanted side-products. A further advantage is that dehydrogenation of the solvent cannot occur, which would be a competing reaction to the dehydrogenation of the formamide. When the solvent is an aprotic solvent, the solvent is preferably an aromatic hydrocarbon or an ether. When the solvent is an aromatic hydrocarbon or an ether, the solvent is preferably toluene, dioxane or cyclopentyl methyl ether (CPME), more preferably CPME.

[0050] The process according to the invention involves a catalyst, wherein the catalyst is a Group VII, VIII or IX transition metal complex.

[0051] According to an embodiment of the invention, the catalysis is based on a metal-ligand cooperation (MLC). MLC involves metal-ligand complexes which form a bi-functional system. Such systems are typically more active than classical metal catalysts. The design of the ligands used in the bi-functional system, allow the electronic and structural properties of the transition metal to be varied. Furthermore, the ligands can actively participate in the key bond-forming and/or bond-breaking steps.

[0052] Different strategies can be applied in order to increase the activity of the catalysts and/or to change the structure and electronic properties of the metal centre. For example, the ligands can i) act as Lewis bases, ii) act as Lewis acids, iii) be aromatised/de-aromatised during the reaction, or iv) act as non-innocent redox-ligands.

[0053] In a preferred embodiment, the transition metal complex contains a non-innocent ligand. For example, the non-innocent ligand is a ligand capable of undergoing de-aromatisation upon deprotonation.

[0054] In a preferred embodiment, the transition metal complex contains a pincer ligand. This has the advantage that the pincer ligand allows the thermal stability of the catalyst to be increased. This is particularly helpful since acceptor-less dehydrogenation reactions require higher reaction temperatures. Preferably, the pincer ligand is a PNP-type pincer ligand or a PNN-type pincer ligand. More preferably, the pincer ligand is a PNP-type pincer ligand.

[0055] In a more preferred embodiment the ligand is a pincer ligand and a non-innocent ligand. Examples of such ligands include, but are not limited to, the following:

##STR00007##

[0056] Most preferably, the pincer ligand that is also a non-innocent ligand is:

##STR00008##

[0057] In a preferred embodiment, the transition metal of the transition metal complex is Ru, Fe, Mn, or Ir. More preferably, the transition metal is Ru.

[0058] In a preferred embodiment according to the invention, the transition metal complex is of the formula

##STR00009##

wherein: [0059] M is a Group VII, VIII or IX transition metal, preferably Ru, Fe, Mn, or Ir, most preferably Ru; [0060] each X, Y and Z are independently P, N, or C; [0061] each R.sub.6 and R.sub.7 are independently Ph.sub.2, (.sup.iPr).sub.2, (.sup.tBu).sub.2 or Et.sub.2; [0062] each R.sub.8 and R.sub.9 are independently H, a C1-C10 alkyl, or a C5-C10 aryl; [0063] each R.sub.10 and R.sub.11 are independently H, a C1-C10 alkyl, or a C5-C10 aryl; [0064] each m and n are independently an integer of 0-3; [0065] p is 0 or 1; and [0066] when p is 1, R.sub.12 is Cl; [0067] wherein optionally: [0068] the carbon attached to R.sub.8 forms a double bond with the carbon attached to R.sub.9; and/or [0069] the carbon attached to Rio forms a double bond with the carbon attached to R.sub.11; and/or [0070] two or more of R.sub.8, R.sub.9, R.sub.10, and R.sub.11 form a ring system, wherein the ring system is preferably an aromatic C.sub.3-C.sub.6 monocyclic ring system, or an aromatic C.sub.9-14 tricyclic ring system; and/or [0071] the carbon attached to R.sub.9 forms a double bond with Y; and/or [0072] the carbon attached to R.sub.10 forms a double bond with Y.

[0073] In a more preferred embodiment, the transition metal complex is

##STR00010## ##STR00011##

[0074] The present invention includes the use of the aforementioned catalysts I, II, and/or III as dehydrogenation catalysts in the formation of free isocyanate.

[0075] According to a preferred embodiment of the present invention, the concentration of the transition metal complex in relation to the formamide is from 0.01 to 1 mol %.

[0076] In an embodiment, the process according to the present invention can provide a yield of more than 20% of the product.

[0077] In an embodiment, the process according to the present invention can provide a selectivity of more than 60%.

[0078] In an embodiment, the process according to the present invention can provide a selectivity of more than 60% and a yield of more than 20% of the product.

[0079] In a most preferred embodiment, the process for the preparation of free isocyanate comprises converting a formamide into the corresponding free isocyanate by catalytic dehydrogenation, [0080] wherein the formamide is brought into contact with a catalyst and is heated between 170-240? C. in a solvent, preferably toluene, dioxane or CPME, most preferably CPME; [0081] wherein the catalyst is a Group VII, VIII or IX transition metal complex; [0082] wherein the transition metal is preferably Ru, Fe, Mn or Ir, most preferably Ru; [0083] wherein the transition metal complex comprises a ligand that is both a pincer ligand and a non-innocent ligand; [0084] wherein the catalytic process for the preparation of the free isocyanate is a homogenous catalytic process; [0085] wherein the process comprises the release of hydrogen; [0086] wherein the isocyanate is a monoisocyanate, a diisocyanate or a polyisocyanate, preferably a diisocyanate; and [0087] wherein the process takes place under inert atmosphere.

[0088] According to a further embodiment of the invention, the conversion of the formamide to the corresponding isocyanate takes place in the presence of an additive. The additive is preferably a base, an acid, or a hydrogen scavenger. The additive may simultaneously function as a solvent.

[0089] When the additive is a base, the additive is preferably 1,8-diazabicyclo [5.4.0]undec-7-ene (DBU), 1,5-diazabicyclo [4.3.0]non-5-ene (DBN), 1,4-diazabicyclo [2.2.2]octane (DABCO) or an alkylamine, more preferably DBU.

[0090] When the additive is an acid, the additive is preferably p-toluenesulfonic acid (p-TsOH).

[0091] When the additive is a hydrogen scavenger (or hydrogen acceptor), it should be a molecule with at least one structure or functional group that can accept a hydrogen molecule. This acceptance can be, in general terms, a hydrogenation. Having more than one of these hydrogen accepting structures may be advantageous. In the best case, this hydrogen accepting structure should be a C/C double or triple bond. Other functional groups or structures that can accept the hydrogen are also possible, provided the resulting protic structure does not react with the product. The remaining part of the molecular structure may also consist of carbon or even heteroatoms. For example, this may include aliphatic, cyclic or aromatic carbons. The hydrogen acceptor is at least a C.sub.2H.sub.2 molecule. Preferably, the hydrogen scavenger is an olefin, more preferably a C.sub.2-C.sub.20 olefin, even more preferably a C.sub.2-C.sub.10 olefin, most preferably 3,3-dimethylbutene (neo-hexene). The addition of a hydrogen scavenger has the advantage that the yield of the product can be improved.

[0092] In an embodiment according to the invention, the mole ratio between the amide and the additive ranges from catalytic amounts to super stoichiometric amounts.

[0093] Overall, the methods described herein have a number of advantages. The present invention provides a process for the preparation of free isocyanate, which improves upon the disadvantages associated with heterogeneous catalysis. In particular, these advantages include but are not limited to the production of free isocyanates in good yields and with good product selectivity. The process according to the present invention (conversion of a formamide into the corresponding isocyanate via a catalytic dehydrogenation reaction) also yields H.sub.2.

EXAMPLES

[0094] Examples according to the present invention will be presented. The following general procedure was utilised to complete the experiments and form the isocyanate product:

[0095] The starting material and the catalyst are dissolved in the solvent under inert atmosphere, placed into the reactor (e.g., an autoclave or microwave) and heated to the desired temperature for the desired time.

[0096] For analytical purposes, the isocyanate product is transformed into the corresponding carbamate. This has the advantage that the carbamate is easier to quantify and is less toxic. The carbamate is synthesised as follows:

[0097] To the above reaction mixture (once the desired reaction time is complete), methanol is added and the mixture is heated to the desired temperature for the desired time. A sample is then taken from the resulting reaction mixture and quantitative data is obtained using GC-FID and an internal standard (e.g., tetradecane).

[0098] For the analysis of the reaction mixtures and the collection of quantitative data, a calibration was carried out in advance. First, a series of separate solutions at different concentrations of each of the individual substrates were prepared. The same amount of an internal standard (for example tetradecane), was added to each concentration mixture. Each of these mixtures was measured on the same device with the same set-up and temperature profile. The linear relationship between the areas under the curve of the substance to be analysed and the internal standard and the respective concentrations was determined (using the software LabSolutions). The linear relationship was then utilised to determine the concentration of the compounds in question (the product in the reaction mixture).

[0099] In order to exclude the possibility that the methanol contributes to the conversion of the formamide to the isocyanate, a series of experiments were completed in the presence of methanol but the absence of the transition metal complex (the catalyst). These experiments confirmed that the carbamate is not formed in the absence of the transition metal complex.

[0100] Gas chromatography-mass spectrometry (GC-MS) was conducted using a Shimadzu GCMS-QP2020 Gas Chromatograph Mass Spectrometer. The column was of the type RTX1 30 m, 0.25 mm, 0.5 ?m; the name of the column used is S88, 1413000; and the gas used was helium. Gas chromatography with flame-ionisation detection (GC-FID) was conducted using a Shimadzu Nexis GC-2030 Gas Chromatograph. The column was of the type RTX-1, 30 m, 0.25 mm, 0.5 ?m; the name of the column used is S114; and the gas used was helium. Experiments which were conducted in an autoclave, were conducted in a stainless steel autoclave with a volume of 10 mL. Experiments which were conducted in a microwave, were conducted in an Anton Paar Monowave 450. 10 mL Anton Paar microwave vials with cap and PTFE septum were used.

[0101] Specific examples of reactions according to the invention will now be discussed and presented in the following tables. The above discussed general procedures were applied, utilising the conditions specified in each of the tables and their titles.

[0102] The below table 1 shows the data for experiments carried out according to the present invention, utilising various starting materials, catalysts and reaction conditions.

[0103] The tested catalysts include catalyst I, catalyst II and catalyst III:

##STR00012##

[0104] It is noted that catalyst I was prepared ex situ from complex I.sup.prime as shown in the figure below. First, .sup.tBuOK was filled into a Schlenk finger. Complex I.sup.prime was filled into another Schlenk finger and dissolved in dry THF. Subsequently, the THF solution was transferred via a cannula into the first Schlenk finger and then stirred for 1 hour at room temperature. After the reaction time, the solvent was removed in vacuo under inert atmosphere. The residues were then dissolved in toluene and filtered under inert atmosphere. The gained solution was concentrated in vacuo to obtain catalyst I.

##STR00013##

TABLE-US-00001 TABLE 1 Process according to the invention. General reaction conditions: the reactions were completed in an autoclave; the solvent added was toluene (2 mL); the starting material (SM), the catalyst (Cat), temperature (Temp), and reaction time (time in hours) are specified in the table. 4 mmol of neo-hexene were added to the reaction mixture prior to heating. The % conversion (Conv), % yield and % selectivity (Selec) were calculated based on the carbamate resulting from reacting the isocyanate with 1.5 mL of methanol for 5 hours at 160? C. Temp Time Yield # SM (mmol) Cat (mol %) (? C.) (hrs) (%) 1 Formanilide (4 mmol) I (0.5) 160 16 9 2 Formanilide (4 mmol) II (0.5) 160 16 5 3 Formanilide (4 mmol) III (0.5) 160 16 13 4 Formanilide (4 mmol) II (0.5) 100 16 1 5 Formanilide (4 mmol) II (0.5) 130 16 2 6 Formanilide (4 mmol) II (0.5) 160 16 5 7 Formanilide (4 mmol) II (0.5) 190 16 9 8 Formanilide (4 mmol) II (0.5) 160 24 5 9 Formanilide (4 mmol) II (0.5) 160 72 8 10 Formanilide (4 mmol) II (0.5) 160 96 9 11.sup.a Formanilide (4 mmol) II (0.5) 160 16 4 12.sup.b Formanilide (4 mmol) I (0.5) 190 16 9 13.sup.b Formanilide (4 mmol) III (0.5) 190 16 13 .sup.aToluene was replaced by xylene (2 mL) as the solvent .sup.bThe % conversion (Conv), % yield and % selectivity (Selec) were calculated based on the carbamate resulting from the reaction of the isocyanate with 1 mL of methanol for 1 hour at 190? C.

[0105] Furthermore, the following reactions were also carried out:

[0106] Following the abovementioned general experimental procedure, a reaction using

##STR00014##

as the starting material (4 mmol) and a separate reaction using

##STR00015##

as the starting material (4 mmol) were completed in an autoclave. The solvent added was toluene (2 mL), the catalyst used was catalyst II (0.5 mol %), the temperature at which the reaction was run was 190? C. and the reaction time for each experiment was 19 hours. 4 mmol of neo-hexene were added to the reaction mixture prior to heating. Upon completion of the reaction time, the GC-MS data indicated that the corresponding free isocyanate was formed.

[0107] Further experiments according to the present invention utilising formanilide as the starting material were completed. The corresponding data is presented in the below table (table 2).

TABLE-US-00002 TABLE 2 Process according to the invention utilising formanilide as the starting material. General reaction conditions: reaction was completed in a microwave; starting material (SM) is formanilide; catalyst (Cat) is catalyst III; % conversion (Conv) , % yield and % selectivity (selec) were calculated based on the carbamate resulting from reaction of the isocyanate with 1 mL of methanol for 1 hour at the same temperature as that utilised for the production of the isocyanate (column Temp in below table). The remaining reaction conditions are listed in the table. SM Temp Time Cat Yield Selec # (mmol) Solvent (? C.) (hours) (mol %) (%) (%) 1 4 Toluene 190 4 1 19 43 (2 mL) 2 4 Toluene 160 4 0.5 26 51 (1 mL) 3 4 Dioxane 160 4 0.25 10 84 (2 mL) 4 4 Dioxane 160 8 0.125 9 62 (2 mL)

[0108] Further experiments according to the present invention utilising formanilide as the starting material were completed. The corresponding data is presented in the below table (table 3). Unless stated otherwise in the table, the following procedure (in accordance with the general procedure outlined above) was applied:

[0109] During the process according to the invention, formanilide and the catalyst III were dissolved in a solvent (2 mL) under inert atmosphere in a microwave-vial. The vial was placed in the microwave and heated for 4 hours. For analytical purposes, upon completion of the 4 hours, methanol (1.5 mL) was added to the vial. The vial was heated to 190? C. for 1 hour. Following this, a sample was taken from the vial and analysed via GC-FID.

TABLE-US-00003 TABLE 3 Process according to the invention utilising formanilide as the starting material. General reaction conditions: reaction was completed in a microwave; starting material (SM) is formanilide; catalyst (Cat) is catalyst III; reaction time is 4 hours; % conversion (Conv), % yield and % selectivity (selec) were calculated based on the carbamate resulting from reaction of the isocyanate with 1.5 mL of methanol for 1 hour at 190? C. The remaining reaction conditions are listed in the table. SM Solvent Temp Cat Conv Yield Selec # (mmol) (2 mL) (? C.) (mol %) (%) (%) (%) 1 0.5 CPME 220 0.25 89 45 51 2 0.75 CPME 220 0.25 88 28 32 3 1.5 CPME 220 0.25 75 20 27 4 1.75 CPME 220 0.25 73 19 26 5 2 Dioxane 160 0.25 22 9 42 6 2 Dioxane 180 0.25 23 10 45 7 2 Dioxane 200 0.25 77 18 24 8 2 Dioxane 220 0.25 66 17 26 9 2 Dioxane 235 0.25 73 15 20 10 2 Dioxane 250 0.25 77 14 18 11 2 THE 180 0.25 21 9 43 12 2 CPME 180 0.25 29 10 35 13 2 2- 180 0.25 25 12 47 Methyl- THF 14 2 ACN 180 0.25 21 6 28 15 2 Pyridine 180 0.25 25 8 33 16 2 TEA 180 0.25 66 14 21 17 2 2- 220 0.25 68 19 28 Methyl- THF 18 2 Pyridine 220 0.25 59 18 30 19 2 CPME 220 0.25 69 18 26 20 4 CPME 220 0.0125 26 2 7 21 1 CPME 220 0.25 63 30 47 22 1 CPME 220 0.5 67 29 42 23 1 CPME 220 0.75 90 27 30 24 1 CPME 220 1 92 25 27 25.sup.a 2 Dioxane 190 0.25 81 16 22 26.sup.b 2 Dioxane 190 0.25 62 24 40 27.sup.c 0.5 CPME 220 0.25 46 31 83 28.sup.d 2 Dioxane 190 0.25 20 13 66 29.sup.e 4 Toluene 190 0.5 28 16 25 30.sup.e 4 Toluene 160 0.5 46 15 34 .sup.aThe reaction was run in the presence of 30 ?l of DBU. .sup.bThe reaction was run in the presence of 3 ?l of DBU. .sup.cThe reaction was run in 1.55 mL of solvent instead of 2 mL. Furthermore, % conversion, % yield and % selectivity were calculated based on the carbamate resulting from reaction of the isocyanate with 1.5 mL of methanol for 1 hour at room temperature. .sup.d% conversion, % yield and % selectivity were calculated based on the carbamate resulting from reaction of the isocyanate with 1.5 mL of methanol for 1 hour at 160? C. .sup.eThe reaction was run utilising catalyst II instead of III. Furthermore, % conversion, % yield and % selectivity were calculated based on the carbamate resulting from reaction of the isocyanate with 1 mL of methanol for 1 hour at 190? C.

[0110] Experiments for several diisocyanate products were also completed. The data in the below table (table 4) was acquired by utilising the corresponding formamide of each of HDI, H12MDI and 2,4-TDI. The specific reaction conditions were as follows:

[0111] The starting material (1 mmol) and catalyst III (0.25 mol %) were dissolved in CPME (2 mL) under inert atmosphere in a microwave-vial. The vial was placed in the microwave and heated to 220? C. for 4 hours.

[0112] For analytical purposes, upon completion of the 4 hours, methanol (1.5 mL) was added to the vial. The vial was heated to 190? C. for 1 hour. Following this, a sample was taken from the vial and analysed via GC-FID.

TABLE-US-00004 TABLE 4 Process according to the invention, producing various diisocyanates. General reaction conditions: the reaction was completed in a microwave; the catalyst is catalyst III (0.25 mol %); the temperature was 220? C., the solvent was CPME (2 mL), the amount of starting material added was 1 mmol, the reaction time was 4 hours. The % conversion, % yield and % selectivity were calculated based on the carbamate resulting from reacting the diisocyanate with 1.5 mL of methanol for 1 hour at 190? C. # Product Conversion (%) Yield (%) Selectivity (%) 1 HDI 23 7 32 2 H12MDI 36 22 62 3 2,4-TDI 74 17 22

[0113] As a precipitate was observed prior to removing a sample for GC-FID analysis, it is noted that the percentages provided in the above table 4 should be considered as the minimum values achievable. Some of the product may have precipitated prior to analysis and could thus not be considered towards the final data in the table. Therefore, the percent conversion, yield and selectivity are presumed to be higher than the values provided in the table.