MULTIVITAMIN EXTRUDATES

Abstract

This invention relates generally to multivitamin extrudates. Their production as well as their use.

Claims

1. An extrudate comprising at least 8 wt-%, based on the total weight of the extrudate, of more than one water soluble vitamins and/or one or more oil-soluble vitamins.

2. Extrudate according to claim 1 comprising up to 95 wt-%, based on the total weight of the extrudate, of more than one vitamin.

3. Extrudate according to claim 1, comprising 8 wt-% to 80 wt-%, based on the total weight of the extrudate, of more than one vitamin.

4. Extrudate according to claim 3, comprising at least three vitamins.

5. Extrudate according to claim 1, comprising more than one vitamin chosen from the group consisting of vitamin A or its esters (for example vitamin A acetate and vitamin A palmitate), vitamin E or its esters (for example vitamin E acetate), vitamin K (phytomenadione) vitamin D3 (cholecalciferol), vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin, niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine, pyridoxamine, pyridoxal), vitamin B7 (biotin), vitamin B9 (folic acid, folinic acid), vitamin B12 (cyanocobalamin, hydroxycobalamin, methylcobalamin), and vitamin C (ascorbic acid).

6. Extrudate according to claim 1, wherein the extrudate only comprises water-soluble vitamins.

7. Extrudate according to claim 1, wherein the extrudate only comprises fat-soluble vitamins.

8. Extrudate according to claim 1, comprising at least one emulsifier.

9. Extrudate according to claim 8, comprising 10-92 wt-%, preferably 15-92 wt-%, more preferably 20-92 wt-%, based on the total weight of the extrudate, of at least one emulsifier.

10. Extrudate according to claim 8, wherein the emulsifier is chosen from the group consisting of modified (food) starches, pectin, alginate, carrageenan, furcellaran, chitosan, maltodextrin, dextrin derivatives, celluloses and cellulose derivatives (e.g. cellulose acetate, methyl cellulose, hydroxypropyl methyl cellulose), lignosulfonate, polysaccharide gums (such as gum acacia, gum arabic, flaxseed gum, ghatti gum, tamarind gum and arabinogalactan), gelatine (bovine, fish, pork, poultry), plant proteins (such as are for example peas, soybeans, castor beans, cotton, potatoes, sweet potatoes, manioc, rapeseed, sunflowers, sesame, linseed, safflower, lentils, nuts, wheat, rice, maize, barley, rye, oats, lupin and sorghum), animal proteins including milk or whey proteins, lecithin, polyglycerol ester of fatty acids, monoglycerides of fatty acids, diglycerides of fatty acids, sorbitan ester, PG ester and sugar ester (as well as derivatives thereof).

11. Extrudate according to claim 1, comprising at least one auxiliary agents.

12. Extrudate according to claim 11 comprising at least one auxiliary agent chosen from the group consisting of antioxidants (such as ascorbic acid or salts thereof, tocopherol (synthetic or natural)); butylated hydroxytoluene (BHT); butylated hydroxyanisole (BHA); propyl gallate; tert. butyl hydroxyquinoline and/or ascorbic acid esters of a fatty acid); ethoxyquin; plasticisers; stabilisers; humectants (such as glycerine, sorbitol, polyethylene glycol); protective colloids; dyes, fragrances; minerals (such as zinc gluconate, copper (II) gluconate, postassium iodide, sodium selenite, ferrous fumarate, tri-calcium phosphate, ferrous sulfate, zinc sulfate); fillers (such as for example micro crystalline cellulose) and buffers.

13. Extrudate according to claim 11, wherein amount of the auxiliary agents goes from 0.1 to 92 wt.-%, based on the total weight of the extrudate.

14. Use of at least one extrudate according to claim 1, in the production of food, feed, pharma and/or personal care formulations and of premixes for food, feed pharma and/or personal care formulations.

15. Food, feed, pharma and/or personal care formulations or premixes for food, feed, pharma and/or personal care formulations comprising at least one extrudate according to claim 1.

Description

EXAMPLES

Example 1: Extruded Multicomponent Particle Comprising all B Vitamins

[0098] This example describes the production of solid, extruded particles comprising all B vitamins (thiamine, riboflavin, pyridoxine, niacin, folic acid and cobalamin). The powder premix containing the B vitamins as well as wheat starch and durum wheat semolina as carrier materials was gravimetrically fed (Brabender Technologie) into the first barrel of a laboratory-scale co-rotating twin screw extruder (Thermo Fisher Scientific, HAAKE Polylab OS with PTW16/40 OS twin screw extruder). The extruder consisted of 10 (electrically heated and water-cooled) barrels and a die head (12 or 210 0.5 mm) with a screw diameter of 16 mm and a length to diameter ratio of 40. Demineralized water was injected into the second barrel. The temperature of barrels 2-10 as well as the die head was set to 20 C. The powder premix was fed at 500 g/h and 60 g/h water was added. The extrudate strands containing the B vitamins were directly die-face cut by two rotating knives at the die head. After die-face cutting the solid particles were dried in a laboratory-scale fluid bed drier (Retsch TG 200) for 60 minutes at 50 C. to obtain a final water content of 6 wt %.

[0099] The content of the dry extrudate particles is shown in Table 1. The Vitamin B2-5-phosphate content was measured by HPLC of the freshly produced extrudate and a recovery of 93% was found.

TABLE-US-00001 TABLE 1 Composition of dry extrudate containing all B vitamins. Ingredient Content, wt % in dry extrudate Thiamine mononitrate (B1) 0.829 Riboflavin 5-phosphate sodium (B2) 0.96 Pyridoxine hydrochloride (B6) 0.74 Niacinamide (B3) 7.28 Folic Acid (B9) 0.19 Vitamin B12 Crystalline 0.001 Wheat starch 45.00 Durum wheat semolina 45.00

Example 2: Extruded Multicomponent Particle Comprising Oil- and Water-Soluble Vitamins

[0100] This example describes the production of solid, extruded particles comprising oil- (Vitamin A acetate, Vitamin D3, Vitamin E acetate) and water-soluble (Vitamin C, thiamine, riboflavin, pyridoxine, niacin, folic acid and cobalamin) vitamins. The production of solid, extruded particles comprising emulsified oil-soluble vitamins as well as water-soluble vitamins was conducted on the laboratory-scale co-rotating twin screw extruder described in Example 1. The emulsifier (modified food starch) as well as the filler (microcrystalline cellulose) were premixed with the water-soluble vitamins as shown in Table 2. This powder premix was gravimetrically fed into the first barrel of the twin screw extruder. Demineralized water was injected into the second barrel. The temperature of barrels 2-10 as well as the die head was set to 50 C. The oil-soluble vitamins Vitamin A acetate, Vitamin D3 crystalline, d,l-alpha-tocopheryl acetate (optionally with added antioxidant such as d,l-alpha tocopherol or butylated hydroxytoluene (BHT)) were molten and premixed at 70 C. (Table 3). This oily melt was injected into barrel 5 and mixed with the other components in the downstream barrels. The powder premix was fed at 750 g/h, the oily premix at 40 g/h and 210 g/h water was added. The extrudate strands containing the oil- and water-soluble vitamins were collected, let to cool down to room temperature and subsequently cut by a pelletizer (Thermo Fisher Scientific). The cut, solid particles were dried in a laboratory-scale fluid bed drier (Retsch TG 200) for 60 minutes at 50 C. to obtain a final water content of 5 wt %.

TABLE-US-00002 TABLE 2 Composition of powder premix for extrusion of water- and oil-soluble vitamins. Ingredient Content, wt % in powder premix Thiamine mononitrate (B1) 0.51 Ribofiavin 5-phosphate sodium (B2) 0.61 Pyridoxine hydrochloride (B6) 0.47 Niacinamide (B3) 4.61 Folic Acid (B9) 0.12 Vitamin B12 Crystalline 0.001 Ascorbic acid fine powder (C) 20.39 Modified food starch 29.32 Microcrystalline cellulose 43.969

TABLE-US-00003 TABLE 3 Composition of oily melt for extrusion of water- and oil-soluble vitamins. Ingredient Content, wt % in oily melt Vitamin A acetate crystalline 7.30 Vitamin D3 crystalline 0.08 d,l-alpha-tocopheryl acetate (E) 91.62 d,l-alpha-tocopherol 1.00

[0101] The content of the dry extrudate particles is shown in Table 4. The Vitamin B2-5-phophate, Vitamin A acetate as well as Vitamin D3 contents were measured by HPLC of the freshly produced extrudate and recoveries of 94%, 89% and 100% were found, respectively.

TABLE-US-00004 TABLE 4 Composition of dry extrudate containing oil- and water-soluble vitamins. Ingredient Content, wt % in dry extrudate Thiamine mononitrate (B1) 0.482 Riboflavin 5-phosphate sodium (B2) 0.577 Pyridoxine hydrochloride (B6) 0.445 Niacinamide (B3) 4.374 Folic Acid (B9) 0.114 Vitamin B12 Crystalline 0.001 Ascorbic acid fine powder (C) 19.35 Modified food starch 27.82 Microcrystalline cellulose 41.73 Vitamin A acetate crystalline 0.373 Vitamin D3 crystalline 0.004 d,l-alpha-tocopheryl acetate (E) 4.679 d,l-alpha-tocopherol 0.051

Example 3: Extruded Multicomponent Particle Comprising Oil-Soluble Vitamins

[0102] This example describes the production of solid, extruded particles comprising oil-soluble (Vitamin A acetate, Vitamin D3, Vitamin E acetate) vitamins. The production of solid, extruded particles comprising emulsified oil-soluble vitamins was conducted on the laboratory-scale co-rotating twin screw extruder described in Example 1. The emulsifier (modified food starch) as well as the filler (microcrystalline cellulose) were premixed at a ratio 2:3. This powder premix was gravimetrically fed into the first barrel of the twin screw extruder. Demineralized water was injected into the second barrel. The temperature of barrels 2-10 as well as the die head was set to 50 C. The oil-soluble vitamins Vitamin A acetate, Vitamin D3 crystalline, d,l-alpha-tocopheryl acetate (optionally with added antioxidant such as d,l-alpha tocopherol or butylated hydroxytoluene (BHT)) were molten and premixed at 70 C. (Table 5). This oily melt was injected into barrel 5 and mixed with the other components in the downstream barrels. The powder premix was fed at 500 g/h, the oily premix at 73 g/h and 300 g/h water was added. The extrudate strands containing the oil- and water-soluble vitamins were collected and subsequently spheronized in batches of 250 g at 1900 rpm for 15 minutes (Gabler R-250). The spheronized, solid particles were dried in a laboratory-scale fluid bed drier (Retsch TG 200) for 60 minutes at 50 C. to obtain a final water content of 4 wt %.

[0103] The content of the dry extrudate particles is shown in Table 6. The Vitamin A acetate as well as Vitamin D3 contents were measured by HPLC of the freshly produced extrudate and recoveries of 88% and 92% were found, respectively.

TABLE-US-00005 TABLE 5 Composition of oily melt for extrusion of oil-soluble vitamins. Ingredient Content, wt % in oily melt Vitamin A acetate crystalline 7.30 Vitamin D3 crystalline 0.08 d,l-alpha-tocopheryl acetate (E) 91.63 d,l-alpha-tocopherol 0.99

TABLE-US-00006 TABLE 6 Composition of dry extrudate containing oil-soluble vitamins. Ingredient Content, wt % in dry extrudate Vitamin A acetate crystalline 0.94 Vitamin D3 crystalline 0.01 d,l-alpha-tocopheryl acetate (E) 11.73 d,l-alpha-tocopherol 0.13 Modified food starch 34.87 Microcrystalline cellulose 52.32