Oral care compositions

Abstract

Described herein are compositions comprising an active compound from an extract of magnolia, or a derivative thereof; and a non-surfactant electrolyte in an amount effective to stabilize the composition, and methods of making and using the same.

Claims

1. An oral care composition comprising: a liquid comprising a mixture of: an antibacterial effective amount of an active compound from an extract of magnolia; sodium sulfate at a concentration of about 2% by weight of the composition; at least one fluoride ion source selected from: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and a combination of two or more thereof; and an orally acceptable carrier, wherein said liquid does not exhibit complete phase separation upon centrifuging at 500 rpm for 2 hours; wherein the active compound is selected from honokiol, tetrahydromagnolol, and tetrahydrohonokiol, and mixtures thereof; and wherein the active compound is present at a concentration of about 1 to about 2% by weight of the composition.

2. The composition according to claim 1, wherein the active compound is honokiol.

3. The composition according to claim 1, wherein the active compound is present at a concentration of about 1 to about 1.5% by weight of the composition.

4. The composition according to claim 1, wherein the active compound is present at a concentration of about 1.3%, by weight of the composition.

5. The composition according to claim 1, wherein the composition is in a form selected from: a mouthrinse, toothpaste, a lozenge, a confectionary, and a dissolvable tablet.

6. The composition according to claim 1, further comprising one or more components selected from: an abrasive, a surfactant, a foaming agent, a vitamin, a polymer, an enzyme, a humectant, a thickener, an antibacterial agent, a preservative, a flavoring agent and a colorant.

7. A method of treating a disease or condition of the oral cavity comprising contacting an oral cavity surface with a composition of claim 1.

8. The method of claim 7, wherein the disease or condition of the oral cavity is selected from gingivitis, periodontitis and halitosis.

Description

EXAMPLES

Example 1

(1) A flavor premix (Part 1) can be made by adding a quantity of flavoring agent and PEG 400 to a quantity of honokiol. This is mixed until the honokiol is fully solubilized. A quantity of sodium lauryl sulfate is then added, and mixed.

(2) An aqueous phase (Part 2) can be prepared by adding a quantity of saccharin, sodium fluoride and sodium sulfate to water. This is mixed until all the solids are substantially dissolved. Glycerin and sorbitol are then added, and mixed until homogenized.

(3) The aqueous phase (Part 2) is added to the flavor premix (Part 1), and mixed until a homogeneous solution is obtained.

Example 2

(4) Product stability can be evaluated using an optical centrifugation method and by visual observation of phase separation. In optical centrifugation, the physical stability is monitored by centrifuging the samples at 500 rpm for 2 hrs and recording phase separation using optical sensors. This method accelerates the ageing process, and the results can be used to predict the long-term stability of a composition.

Example 3

(5) Several compositions were prepared by the process described in Example 1. Table 1 (below) describes the formulations of two exemplary compositions of the present invention (Compositions I and II) and two comparative compositions which do not contain an effective amount of non-surfactant electrolyte (Compositions X and Y).

(6) TABLE-US-00001 TABLE 1 Composition I II X Y Ingredient % w/w Sodium sulfate 2 2 PEG 400 2.8 2.8 2.8 2.8 Gantrez (13% solution) 41 41 41 41 Sodium hydroxide 3.3 3.3 3.3 3.3 (50% solution) Flavor 1.3 1.3 1.3 1.3 Honokiol 1.3 1.3 1.3 1.3 Sodium lauryl sulfate 2.1 2.7 2.1 2.7 Sodium saccharin 0.2 0.2 0.2 0.2 Sodium fluoride 0.1 0.1 0.2 0.1 Sorbitol 11.9 11.2 12.5 11.8 Glycerin 11.8 11.1 12.3 11.7 Water q.s. q.s. q.s. q.s

(7) Physical stability of the compositions was measured on a scale of 1 to 10; wherein stability is measured in terms of clarity and phase separation. A score of 10 indicates that the phases remain substantially unseparated; while a score of 1 indicates that an unacceptable level of phase separation has occurred. Phase separation can be used to identify a product having unacceptable long-term stability.

(8) Compositions I and II, having physical stability scores of 7 and 6.5, respectively, demonstrated minimal phase separation; while complete phase separation was observed in Compositions X and Y, which had physical stability scores of 5 and 2.8, respectively. These results demonstrate that the addition of an effective amount of a non-surfactant electrolyte to a formulation comprising an active compound from an extract of magnolia, as described herein, provides a composition with acceptable long-term stability; whereas similarly formulated compositions lacking an effective amount of a non-surfactant electrolyte as described herein, do not have acceptable long-term stability.

(9) TABLE-US-00002 TABLE 2 Composition Physical Stability Score I 7 II 6.5 X 5 Y 2.8

(10) As those skilled in the art will appreciate, numerous changes and modifications may be made to the embodiments described herein without departing from the spirit of the invention. It is intended that all such variations fall within the scope of the appended claims.