Methods for Determining Equivalent Alkane Carbon Number

Abstract

Disclosed herein are methods to determine the equivalent alkane carbon number (EACN) of a composition comprising an oil.

Claims

1-24. (canceled)

25. A method for determining the equivalent alkane carbon number (EACN) of a composition comprising oil, the method comprising; a. mixing one or more compositions comprising; i. a compound having Formula (I) Ca.sub.a—(PO).sub.b-(EO).sub.c-SO.sub.4Na, where a is from 6 to 18, b is from 1 to 12, and c is from 0 to 4; ii. one or more oils; iii. water; and iv. a salt; b. determining the salt concentration which produces an equal volume of oil and volume of water within a formed microemulsion; c. determining the equivalent alkane carbon number using Formula (II) HLD=ln(S)−K.Math.EACN+Cc−f(A)−α.sub.TΔ(T); where HLD is the hydrophilic-lipophilic deviation value, S is the salt concentration producing equal volume of oil and volume of water within a formed microemulsion, K is an empirical constant, EACN is the equivalent alkane carbon number of the oil phase, Cc is a constant characterizing the hydrophilicity and lipophilicity of the compound of Formula (I), f(A) is a function of added alcohol, α.sub.T is an empirical constant, and Δ(T) is the temperature deviation from 25° C.

26. The method according to claim 25, wherein the salt is selected from sodium chloride, potassium chloride, ammonium chloride, calcium chloride, magnesium chloride, and a combination of two or more thereof.

27. The method according to claim 25, wherein the salt is present at an amount of about 1 wt. % to about 10 wt. %.

28. The method according to claim 25, wherein the salt is present at an amount of about 10 wt. % to about 25 wt. %.

29. The method according to claim 25, wherein at least one of the one or more oils is non-polar.

30. The method according to claim 25, wherein at least one of the one or more compositions further comprises a solubilizer.

31. The method according to claim 30, wherein the solubilizer is pre-mixed with at least one of the one or more oils.

32. The method according to claim 25, wherein at least one of the one or more oils comprises a water-soluble solvent.

33. The method according to claim 25, wherein a is from 7 to 9, b is from 3 to 5, and c is from 1 to 2.

34. The method according to claim 25, wherein a is 8, b is 4, and c is 1.

35. A method for determining the equivalent alkane carbon number (EACN) of a composition comprising oil, the method comprising; a. mixing one or more compositions consisting essentially of; i. a compound having Formula (I) Ca.sub.a—(PO).sub.b-(EO).sub.c-SO.sub.4Na, where a is from 6 to 18, b is from 1 to 12, and c is from 0 to 4; ii. one or more oils; iii. water; and iv. a salt; b. determining the salt concentration which produces an equal volume of oil and volume of water within a formed microemulsion; c. determining the equivalent alkane carbon number using Formula (II) HLD=ln(S)−K.Math.EACN+Cc−f(A)−α.sub.TΔ(T); where HLD is the hydrophilic-lipophilic deviation value, S is the salt concentration producing equal volume of oil and volume of water within a formed microemulsion, K is an empirical constant, EACN is the equivalent alkane carbon number of the oil phase, Cc is a constant characterizing the hydrophilicity and lipophilicity of the compound of Formula (I), f(A) is a function of added alcohol, α.sub.T is an empirical constant, and Δ(T) is the temperature deviation from 25° C.

36. The method according to claim 35, wherein the salt is selected from sodium chloride, potassium chloride, ammonium chloride, calcium chloride, magnesium chloride, and a combination of two or more thereof.

37. The method according to claims 35, wherein the salt is present at an amount of about 1 wt. % to about 10 wt. %.

38. The method according to claim 35, wherein the salt is present at an amount of about 10 wt. % to about 25 wt. %.

39. The method according to claim 35, wherein at least one of the one or more oils is non-polar.

40. The method according to claim 35, wherein the one or more oils comprise a polar oil and a non-polar oil.

41. The method according to claim 35, wherein at least one of the one or more compositions further comprises a solubilizer.

42. The method according to claim 41, wherein the solubilizer is pre-mixed with at least one of the one or more oils.

43. The method according to claim 35, wherein the one or more oils comprises a water-soluble solvent.

44. The method according to claim 35, wherein a is from 7 to 9, b is from 3 to 5, and c is from 1 to 2.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0011] FIG. 1 depicts the microemulsion phase behavior of Fragrance “J” with 2 wt. % SAS-C.sub.8 solution at various NaCl concentrations.

DETAILED DESCRIPTION

[0012] For illustrative purposes, the principles of the present invention are described by referencing various exemplary embodiments thereof. Although certain embodiments of the invention are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable to, and can be employed in other applications and methods. It is to be understood that the invention is not limited in its application to the details of any particular embodiment shown. The terminology used herein is for the purpose of description and not to limit the invention, its application, or uses.

[0013] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context dictates otherwise. The singular form of any class of the ingredients refers not only to one chemical species within that class, but also to a mixture of those chemical species. The terms “a” (or “an”), “one or more” and “at least one” may be used interchangeably herein. The terms “comprising”, “including”, “containing”, and “having” may be used interchangeably. The term “include” should be interpreted as “include, but are not limited to”. The term “including” should be interpreted as “including, but are not limited to”.

[0014] As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range.

[0015] Unless otherwise specified, all percentages and amounts expressed herein and elsewhere in the specification should be understood to refer to percentages by weight of the total composition. Reference to a molecule, or to molecules, being present at a “wt. %” refers to the amount of that molecule, or molecules, present in the composition based on the total weight of the composition.

[0016] According to the present application, use of the term “about” in conjunction with a numeral value refers to a value that may be +/−5% of that numeral. As used herein, the term “substantially free” is intended to mean an amount less than about 5.0 weight %, less than 3.0 weight %, 1.0 wt. %; preferably less than about 0.5 wt. %, and more preferably less than about 0.25 wt. % of the composition. As used herein, the term “free”, when used with reference to one or more components, means that the cited component(s) is not present in the composition at all. For example, “free of supporting oil” means that no supporting oil is present in the composition.

[0017] As used herein, the term “effective amount” refers to an amount that is effective to elicit the desired biological response, including the amount of a composition that, when administered to a subject, is sufficient to achieve an effect toward the desired result. The effective amount may vary depending on the composition, the disease, and its severity and the age, weight, etc., of the subject to be treated. The effective amount can include a range of amounts. As is understood in the art, an effective amount may be in one or more doses, i.e., a single dose or multiple doses may be required to achieve the desired endpoint.

[0018] As used herein, the term “physicochemical property” or “physicochemical properties” may refer to physical properties, solvation properties related to interactions with different media, and properties or molecular attributes that define intrinsic chemical reactivity.

[0019] Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs. All patents, patent applications, publications, and other references cited or referred to herein are incorporated by reference in their entireties for all purposes. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0020] The present disclosure is directed towards methods to determine the EACN of a composition comprising one or more oils. In certain embodiments, the methods comprise utilization of a sodium alkoxy sulfate surfactant. The sodium alkoxy sulfate surfactant may have the formula of Formula (I):

Ca.sub.a—(PO).sub.b-(EO).sub.c-SO.sub.4Na   Formula (I)

where a is from 6 to 18, b is from 1 to 12, and c is from 0 to 4. In certain embodiments, the sodium alkoxy sulfate surfactant has the Formula (Ia) C.sub.8—(PO).sub.4-EO-SO.sub.4Na (known commercially as Alfoterra K2-41s or Alfoterra 8-41s from Sasol and herein referred to as SAS-C.sub.8). The methods provide accurate and predictable EACN values with a wide range of oils, from hydrophilic fragrances to very hydrophobic alkanes. Further, the present inventors have surprisingly and unexpectedly discovered that sodium alkoxy sulfate surfactants, such as SAS-C.sub.8, may be utilized to determine EACN values without the need to also use a further supporting oil.

[0021] In certain embodiments, the method comprises mixing one or more compositions comprising one or more oils, water, salt, and a compound having Formula (I) Ca.sub.a—(PO).sub.b-(EO).sub.c-SO.sub.4Na, where a is from 6 to 18, b is from 1 to 12, and c is from 0 to 4; determining the salt concentration which produces an equal volume of oil and volume of water within a formed microemulsion; and determining the equivalent alkane carbon number using Formula (II) HLD=ln(S)−K.Math.EACN+Cc−f(A)−α.sub.TΔ(T); where HLD is the hydrophilic-lipophilic deviation value, S is the salt concentration producing equal volume of oil and volume of water within a formed microemulsion, K is an empirical constant, EACN is the equivalent alkane carbon number of the oil phase, Cc is a constant characterizing the hydrophilicity and lipophilicity of the compound of Formula (I), f(A) is a function of added alcohol, α.sub.T is an empirical constant, and Δ(T) is the temperature deviation from 25° C.

[0022] In other embodiments, the method comprises mixing one or more compositions consisting essentially of one or more oils, water, salt, and a compound having Formula (I) Ca.sub.a—(PO).sub.b-(EO).sub.c-SO.sub.4Na, where a is from 6 to 18, b is from 1 to 12, and c is from 0 to 4; determining the salt concentration which produces an equal volume of oil and volume of water within a formed microemulsion; and determining the equivalent alkane carbon number using Formula (II) HLD=ln(S)−K.Math.EACN+Cc−f(A)−α.sub.TΔ(T); where HLD is the hydrophilic-lipophilic deviation value, S is the salt concentration producing equal volume of oil and volume of water within a formed microemulsion, K is an empirical constant, EACN is the equivalent alkane carbon number of the oil phase, Cc is a constant characterizing the hydrophilicity and lipophilicity of the compound of Formula (I), f(A) is a function of added alcohol, α.sub.T is an empirical constant, and Δ(T) is the temperature deviation from 25° C.

[0023] The present invention utilizes a sodium alkoxy sulfate surfactant having the formula of Formula (I): Ca.sub.a—(PO).sub.b-(EO).sub.c-SO.sub.4Na, where a is from 6 to 18, b is from 1 to 12, and c is from 0 to 4. In certain embodiments, a is from 6 to 10. In certain embodiments, b is from 1 to 7. In certain embodiments, c is from 1 to 3. In certain embodiments, a is from 6 to 10, b is from 1 to 7, and c is from 1 to 3. In other embodiments, a is from 7 to 9, b is from 3 to 5, and c is from 1 to 2. In further embodiments, a is 8, b is 4, and c is 1.

[0024] The invention requires use of salt. Salts useful in the invention include, but are not limited to, NaCl, CaCl.sub.2, MgCl.sub.2, and KCl, and mixtures thereof. In certain embodiments, the salt is selected from sodium chloride, potassium chloride, ammonium chloride, calcium chloride, magnesium chloride, or a mixture thereof. In certain embodiments, the salt comprises NaCl. In other embodiments, the salt is NaCl. The salt may be present at various amounts or concentrations. In certain embodiments, the salt is present in an amount from about 1 wt. % to about 30 wt. %. For example, salt may be present in an amount of about 1.0 weight %, 2.0 weight %, about 2.5 weight %, about 3.0 weight %, about 3.5 weight %, about 4.0 weight %, about 4.5 weight %, about 5.0 weight %, about 5.5 weight %, about 6.0 weight %, about 6.5 weight %, about 7.0 weight %, about 7.5 weight %, about 8.0 weight %, about 8.5 weight %, about 9.0 weight %, about 9.5 weight %, about 10.0 weight %, about 10.5 weight %, about 11.0 weight %, about 11.5 weight %, about 12.0 weight %, about 12.5 weight %, about 13.0 weight %, about 13.5 weight %, about 14.0 weight % about 15.0 weight %, about 20.0 weight %, about 25.5 weight %, or about 30.0 weight %. In another example, salt may be present in an amount of from about 1.0% to about 10.0%, from about 2.0% to about 6.0%, from about 4 wt. % to about 6 wt. %, about 10.0% to about 30.0%, from about 10% to about 25%, about 15.0% to about 30.0%, or about 5.0% to about 28.0%, based on the weight of the composition. In further embodiments, salt is present in an amount of about 1.0% or more, about 4.0% or more, about 10.0% or more, or about 15.0% or more up to about 30.0%, based on the weight of the composition. In further embodiments, salt is present in an amount of about 3.5% to 5.5%, about 5.0% to about 15.0%, about 10.0% to about 20.0%, or about 2.0% to about 20.0%, based on the weight of the composition.

[0025] A microemulsion is an equilibrium dispersion of oil-in-water (Type I) or water-in-oil (Type II). The hydrophilic lipophilic deviation (HLD) value measures the departure of a microemulsion's thermodynamic state from the optimum Type III (bicontinuous) formulation. Negative, zero, or positive HLD values suggest the formation of Type I, Type III or Type II microemulsions, respectively.

[0026] Determination of salt concentration which produces an equal volume of oil and volume of water within a formed microemulsion, or Type III bicontinuous formulation, may be performed using techniques not requiring complex equipment. For example, an equal volume of oil composition and aqueous composition may be combined with SAS-C.sub.8 and salt. The composition may then be mixed and allowed to equilibrate. Equilibration may occur at about 25° C. Visual inspection of the composition phase behavior may then be performed to determine if a microemulsion having an equal volume of oil and volume of water is formed. When such a microemulsion is formed, then HLD=0. The salt concentration producing such microemulsion (may be referred to as “optimal salt concentration”) may then be used to calculate the equivalent alkane carbon number (EACN). Typically, multiple compositions of varying salt concentration are used to make this determination.

[0027] Upon determination of the optimal salt concentration, Formula (II):

HLD=ln(S)−K.Math.EACN+Cc−f(A)−α.sub.TΔ(T)   Formula (II)

may be used to determine the EACN. HLD is the hydrophilic-lipophilic deviation value, S is the salt concentration producing equal volume of oil and volume of water within a formed microemulsion, K is an empirical constant, EACN is the equivalent alkane carbon number of the oil phase, Cc is a constant characterizing the hydrophilicity and lipophilicity of the compound of Formula (I), f(A) is a function of added alcohol, α.sub.T is an empirical constant, and Δ(T) is the temperature deviation from 25° C.

[0028] The inventive methods are useful for application with various oil(s). In some embodiments, the oil may be a fragrance oil. In some embodiments, the oil may be another oil type. In some embodiments, the oil may be a mixture of oils. In some embodiments, the oil may contain water soluble solvents. In some embodiments, the water soluble solvent is dipropylene glycol. In some embodiments, the one or more oils are non-polar. In some embodiments, the one or more oils comprise a polar oil and a non-polar oil.

[0029] The inventive methods may utilize a surfactant or solubilizer. Suitable surfactants include neutral surfactants (such as polyoxyethylene hydrogenated castor oil or fatty acids of sugars), anionic surfactants (such as sodium lauryl sulfate), cationic surfactants (such as the ammonium cation surfactants) or zwitterionic surfactants. In some embodiments, the compositions of the present disclosure include at least one surfactant that is a polyoxyethylene (polyethylene glycol; PEG) hydrogenated castor oil. Suitable PEG-40 hydrogenated castor oils include, for example, those sold by BASF under the name Cremophor RH 410 and Cremophor RH 40. Those of skill in the art will appreciate that for PEG-40 hydrogenated castor oils having higher percentages of active, for example Cremophor RH 40, which is typically provided as a pure (i.e., 100%) composition of PEG hydrogenated castor oil, a correspondingly smaller amount of such PEG-40 hydrogenated castor oil would be employed. In some embodiments, the surfactant is anionic. In certain embodiments, the surfactant is nonionic. In certain embodiments, the surfactant is amphoteric. In certain embodiments, the amphoteric surfactant is cocamidopropyl betaine.

[0030] The mass ratio of surfactant to the compound of Formula (I) may vary. In some embodiments, the mass ratio of surfactant to the compound of Formula (I) is from about 1:1 to about 1:8. In some embodiments, the mass ratio of surfactant to the compound of Formula (I) is from about 1:2 to about 1:6. In some embodiments, the mass ratio of surfactant to the compound of Formula (I) is about 1:4.

EXAMPLE

[0031] A total of 5 mL fragrance oil and 5 mL of an aqueous phase containing 2 wt. % reference surfactant SAS-C.sub.8 (Alfoterra k2-41s, Sasol, South Africa) along with NaCl were added into a vial, hand-shaken once a day for three sequential days and allowed to equilibrate at 25° C. Multiple vial samples were prepared, each having a particular NaCl concentration, in order to yield a range of NaCl concentrations. Visual observation was made to determine formation of a middle phase microemulsion. The NaCl concentration providing for a defined middle phase microemulsion system having an equal volume of oil in the microemulsion and water in the microemulsion is referred to as the optimal formulation and used to determine the optimal salinity (S*).

[0032] Determination of EACN was made by use of Formula (II):

HLD=ln(S)−K.Math.EACN+Cc−f(A)+α.sub.TΔ(T),   Formula (II)

where HLD is the hydrophilic-lipophilic deviation value, S is the salt concentration producing equal volume of oil and volume of water within a formed microemulsion, K is an empirical constant, EACN is the equivalent alkane carbon number of the oil phase, Cc is a constant characterizing the hydrophilicity and lipophilicity of the surfactant used (C.sub.8—(PO).sub.4-EO-SO.sub.4Na), f(A) is a function of added alcohol (f(A) is 0 for formulations without alcohol), α.sub.T is an empirical constant and Δ(T) is the temperature deviation from 25° C. (α.sub.TΔ(T) is 0 when at a constant temperature of 25° C.). Therefore, when experimentation is performed at constant 25° C. and without added alcohol, then f(A)−α.sub.TΔ(T) equals 0. When the optimal formulation is achieved, or an equal volume of oil in the microemulsion and water in the microemulsion exists, then HLD=0 and S=S*. The SAS-C.sub.8 surfactant was a 28.7% active solution having a k value of 0.053 and a Cc value of −2.47.

[0033] FIG. 1 shows the results of testing with the Fragrance “J”. NaCl concentrations from left to right are 4.6, 4.8, 5.0, 5.2, 5.4, 5.6 wt. %. A NaCl concentration of 5.0 wt. % shows the optimum concentration, therefore HLD=0 at this NaCl concentration. Using Formula (II), EACN of Fragrance “J” was calculated to be −14.8.

[0034] Table 1 shows the average EACN values (n=3) and standard deviation for various fragrances.

TABLE-US-00001 TABLE 1 Standard Fragrance EACN Deviation A −33.3  2.7 B −28.3  0.8 C −27.6  0.4 D −25.5  1.2 E −24.3  1.2 F −21.5  0.5 G −20.0  1.0 H −18.1  0.5 I −16.4  0.8 J −14.8  0.8 K −14.8  0.8 Limonene −0.9  1.0 Vitamin E 5.2 0.8 Isopropyl 7.8 0.6 myristate Flaxseed oil 13.0  0.5 Olive oil 15.0  0.5

[0035] While the present invention has been described with reference to several embodiments, which embodiments have been set forth in considerable detail for the purposes of making a complete disclosure of the invention, such embodiments are merely exemplary and are not intended to be limiting or represent an exhaustive enumeration of all aspects of the invention. The scope of the invention is to be determined from the claims appended hereto. Further, it will be apparent to those of skill in the art that numerous changes may be made in such details without departing from the spirit and the principles of the invention.