SUBSTITUTED CYCLIC ARYL AND HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS

Abstract

The invention relates to substituted cyclic aryl- and heteroarylcarbonyl hydrazides of the general formula (I) or salts thereof

##STR00001##

where the radicals of the formula (I) are each as defined in the description for enhancing stress tolerance in plants to abiotic stress, and for enhancing plant growth and/or for increasing plant yield.

Claims

1. A substituted cyclic aryl- or heteroarylcarbonyl hydrazide of formula (I) or salt thereof ##STR00115## in which R.sup.1, R.sup.2 and R.sup.38 are independently hydrogen, halogen, cyano, nitro, NR.sup.39R.sup.40, OR.sup.41, S(O).sub.nR.sup.42, thiocyanato, isothiocyanato, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, pentafluorothio, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylcarbonyl-(C.sub.1-C.sub.8)-alkyl, COOR.sup.42, CONR.sup.39R.sup.40, COR.sup.41, CNOR.sup.41, R.sup.41OOC(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkynyl, heteroaryl-(C.sub.1-C.sub.8)-alkynyl, heterocyclyl-(C.sub.1-C.sub.8)-alkynyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.2-C.sub.8)-alkynyl, bis[(C.sub.1-C.sub.8)-alkyl](aryl)silyl-(C.sub.2-C.sub.8)-alkynyl, bisaryl[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.2-C.sub.8)-alkynyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.2-C.sub.8)-alkynyl, aryl-(C.sub.2-C.sub.8)-alkenyl, heteroaryl-(C.sub.2-C.sub.8)-alkenyl, heterocyclyl-(C.sub.2-C.sub.8)-alkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.2-C.sub.8)-alkenyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylaminosulfonylamino, (C.sub.3-C.sub.8)-cycloalkylaminosulfonylamino, diazo, aryldiazo, tris[(C.sub.1-C.sub.8)-alkyl]silyl, bis[(C.sub.1-C.sub.8)-alkyl](aryl)silyl, bisaryl[(C.sub.1-C.sub.8)-alkyl]silyl, X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are the same or different and are independently N (nitrogen) or the CR.sup.2 moiety, but there are never more than two adjacent nitrogen atoms, and where R.sup.2 in each CR.sup.2 moiety is the same or different as defined below, and where R.sup.1 and R.sup.2 are not both hydrogen when X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are CR.sup.2, W is O (oxygen) or S (sulfur), A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 are the same or different and are each independently N (nitrogen) or the CR.sup.38 moiety, but there are never more than two adjacent nitrogen atoms, and where R.sup.38 in each CR.sup.38 moiety is the same or different as defined above, Q together with the CR.sup.3R.sup.4 group and the nitrogen atom to which they are bonded forms a fully saturated, partly saturated or fully unsaturated 3-7-membered ring which is optionally interrupted by heteroatoms and optionally has further substitution, and is additionally the moieties Q-1 to Q-15 ##STR00116## ##STR00117## where R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25, R.sup.26, R.sup.27, R.sup.28, R.sup.29, R.sup.30, R.sup.31, R.sup.32, R.sup.33, R.sup.34, R.sup.35, R.sup.36 and R.sup.37 are each defined according to the definitions above and where the arrow represents a bond to the nitrogen atom of the hydrazide group, R.sup.3, R.sup.4, R.sup.17, R.sup.18, R.sup.19 and R.sup.20 are independently hydrogen, (C.sub.1-C.sub.8)-alkyl, halogen, NR.sup.39R.sup.40, S(O).sub.nR.sup.42, cyano, nitro, cyano-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.10)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-haloalkenyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylamino-(C.sub.1-C.sub.8)-alkyl, bis[(C.sub.1-C.sub.8)-alkyl]amino-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkylamino-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkynyloxycarbonyl-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylcarbonyl-(C.sub.1-C.sub.8)-alkyl or together with the atom to which they are bonded form an oxo group, R.sup.5 and R.sup.6 are independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkylthio-(C.sub.1-C.sub.8)-alkyl, COOR.sup.41, CONR.sup.39R.sup.40, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkynyloxycarbonyl-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, heteroaryl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25, R.sup.26, R.sup.27, R.sup.28, R.sup.29, R.sup.30, R.sup.31, R.sup.32, R.sup.33, R.sup.34, R.sup.35 and R.sup.36 are independently hydrogen, cyano, nitro, halogen, hydroxyl, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.1-C.sub.10)haloalkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-haloalkenyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkylthio-(C.sub.1-C.sub.8)-alkyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, R.sup.37 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.2-C.sub.8)-alkenyloxy, aryl, heteroaryl, heterocyclyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, S(O).sub.nR.sup.42, n is 0, 1 or 2, R.sup.39 and R.sup.40 are the same or different and are independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, COR.sup.41, SO.sub.2R.sup.42, (C.sub.1-C.sub.8)-alkyl-HNO.sub.2S, (C.sub.3-C.sub.8)-cycloalkyl-HNO.sub.2S, heterocyclyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl, heteroaryl-(C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl, (C.sub.2-C.sub.8)-alkynyloxycarbonyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, R.sup.41 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl and R.sup.42 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, NR.sup.39R.sup.40 Y is a bond or the Y-1 to Y-7 moieties ##STR00118## where R.sup.43, R.sup.44, R.sup.45, R.sup.46, R.sup.47, R.sup.48, R.sup.49, R.sup.50, R.sup.51, R.sup.52, R.sup.53 and R.sup.54 are each as per the definition below and where the arrow represents a bond to the 6-membered ring with the A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 moieties, R.sup.43, R.sup.44, R.sup.45, R.sup.46, R.sup.47, R.sup.48, R.sup.49, R.sup.50, R.sup.51, R.sup.52, R.sup.53 and R.sup.54 are independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkylthio-(C.sub.1-C.sub.8)-alkyl, COOR.sup.23, R.sup.1 and X.sup.1, when X.sup.1 is a CR.sup.2 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, X.sup.1 and X.sup.2, when each is a CR.sup.2 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.1 and A.sup.2, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.2 and A.sup.3, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.3 and A.sup.4, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.5 and R.sup.6 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.3 and X.sup.23 together with the atoms to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.9 and R.sup.10 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution and R.sup.15 and R.sup.16 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution.

2. A substituted cyclic aryl- or heteroarylcarbonyl hydrazide or salt as claimed in claim 1, where R.sup.1, R.sup.2 and R.sup.38 are independently hydrogen, halogen, cyano, nitro, NR.sup.39R.sup.40, OR.sup.41, S(O).sub.nR.sup.42, thiocyanato, isothiocyanato, (C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.7)-haloalkenyl, (C.sub.2-C.sub.7)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, pentafluorothio, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-alkyl, aryl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylcarbonyl-(C.sub.1-C.sub.7)-alkyl, COOR.sup.42, CONR.sup.39R.sup.40, COR.sup.41 CNOR.sup.41, R.sup.41OOC(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkynyl, heteroaryl-(C.sub.1-C.sub.7)-alkynyl, heterocyclyl-(C.sub.1-C.sub.7)-alkynyl, tris[(C.sub.1-C.sub.7)-alkyl]silyl-(C.sub.2-C.sub.7)-alkynyl, bis[(C.sub.1-C.sub.7)-alkyl](aryl)silyl-(C.sub.2-C.sub.7)-alkynyl, bisaryl [(C.sub.1-C.sub.7)-alkyl]silyl-(C.sub.2-C.sub.7)-alkynyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.2-C.sub.7)-alkynyl, aryl-(C.sub.2-C.sub.7)-alkenyl, heteroaryl-(C.sub.2-C.sub.7)-alkenyl, heterocyclyl-(C.sub.2-C.sub.7)-alkenyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.2-C.sub.7)-alkenyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylaminosulfonylamino, (C.sub.3-C.sub.7)-cycloalkylaminosulfonylamino, diazo, aryldiazo, tris[(C.sub.1-C.sub.7)-alkyl]silyl, bis[(C.sub.1-C.sub.7)-alkyl](aryl)silyl, bisaryl[(C.sub.1-C.sub.7)-alkyl]silyl, X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are the same or different and are independently N (nitrogen) or the CR.sup.2 moiety, but there are never more than two adjacent nitrogen atoms, and where R.sup.2 in each CR.sup.2 moiety is the same or different as defined below, and where R.sup.1 and R.sup.2 are not both hydrogen when X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are CR.sup.2, W is O (oxygen) or S (sulfur), A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 are the same or different and are each independently N (nitrogen) or the CR.sup.38 moiety, but there are never more than two adjacent nitrogen atoms, and where R.sup.38 in each CR.sup.38 moiety is the same or different as defined above, Q together with the CR.sup.3R.sup.4 group and the nitrogen atom to which they are bonded forms a fully saturated, partly saturated or fully unsaturated 3-7-membered ring which is optionally interrupted by heteroatoms and optionally has further substitution, and is additionally the moieties Q-1 to Q-15 ##STR00119## ##STR00120## where R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25, R.sup.26, R.sup.27, R.sup.28, R.sup.29, R.sup.30, R.sup.31, R.sup.32, R.sup.33, R.sup.34, R.sup.35, R.sup.36 and R.sup.37 are each defined according to the definitions above and where the arrow represents a bond to the nitrogen atom of the hydrazide group, R.sup.3, R.sup.4, R.sup.17, R.sup.18, R.sup.19 and R.sup.20 are independently hydrogen, halogen, NR.sup.39R.sup.40, S(O).sub.nR.sup.42, cyano, nitro, cyano-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.10)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-haloalkynyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-haloalkenyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylamino-(C.sub.1-C.sub.7)-alkyl, bis[(C.sub.1-C.sub.7)-alkyl]amino-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkylamino-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, hydroxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyloxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkynyloxycarbonyl-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylcarbonyl-(C.sub.1-C.sub.7)-alkyl or together with the atom to which they are bonded form an oxo group, R.sup.5 and R.sup.6 are independently hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.7)-haloalkenyl, (C.sub.2-C.sub.7)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, aryl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkylthio-(C.sub.1-C.sub.7)-alkyl, COOR.sup.41, CONR.sup.39R.sup.40, hydroxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyloxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkynyloxycarbonyl-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, heteroaryl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25, R.sup.26, R.sup.27, R.sup.28, R.sup.29, R.sup.30, R.sup.31, R.sup.32, R.sup.33, R.sup.34, R.sup.35 and R.sup.36 are independently hydrogen, cyano, nitro, halogen, hydroxyl, (C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy, (C.sub.1-C.sub.7)-alkylthio, (C.sub.1-C.sub.7)-haloalkoxy, (C.sub.1-C.sub.7)-haloalkylthio, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.1-C.sub.10)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-haloalkynyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-haloalkenyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkylthio-(C.sub.1-C.sub.7)-alkyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, R.sup.37 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.1-C.sub.7)-alkoxy, (C.sub.2-C.sub.7)-alkenyloxy, aryl, heteroaryl, heterocyclyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, S(O).sub.nR.sup.42, n is 0, 1 or 2, R.sup.39 and R.sup.40 are the same or different and are independently hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.1-C.sub.7)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.7)-haloalkenyl, (C.sub.2-C.sub.7)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.7)-alkyl, COR.sup.41, SO.sub.2R.sup.42, (C.sub.1-C.sub.7)-alkyl-HNO.sub.2S, (C.sub.3-C.sub.7)-cycloalkyl-HNO.sub.2S, heterocyclyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl, heteroaryl-(C.sub.1-C.sub.7)-alkoxycarbonyl, (C.sub.2-C.sub.7)-alkenyloxycarbonyl, (C.sub.2-C.sub.7)-alkynyloxycarbonyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, R.sup.41 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.1-C.sub.7)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.7)-haloalkenyl, (C.sub.2-C.sub.7)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyloxycarbonyl-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, hydroxycarbonyl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl and R.sup.42 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.1-C.sub.7)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.7)-haloalkenyl, (C.sub.2-C.sub.7)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.7)-alkyl, NR.sup.39R.sup.40. Y is a bond or the Y-1 to Y-7 moieties ##STR00121## where R.sup.43, R.sup.44, R.sup.45, R.sup.46, R.sup.47, R.sup.48, R.sup.49, R.sup.50, R.sup.51, R.sup.52, R.sup.53 and R.sup.54 are each as per the definition below and where the arrow represents a bond to the 6-membered ring with the A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 moieties, R.sup.43, R.sup.44, R.sup.45, R.sup.46, R.sup.47, R.sup.48, R.sup.49, R.sup.50, R.sup.51, R.sup.52, R.sup.53 and R.sup.54 are independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.2-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkylthio-(C.sub.1-C.sub.8)-alkyl, COOR.sup.23, R.sup.1 and X.sup.1, when X.sup.1 is a CR.sup.2 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, X.sup.1 and X.sup.2, when each is a CR.sup.2 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.1 and A.sup.2, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.2 and A.sup.3, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.3 and A.sup.4, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.5 and R.sup.6 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.3 and R.sup.23 together with the atoms to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.9 and R.sup.10 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution and R.sup.15 and R.sup.16 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution.

3. A substituted cyclic aryl- or heteroarylcarbonyl hydrazide or salt as claimed in claim 1, where R.sup.1, R.sup.2 and R.sup.38 are independently hydrogen, halogen, cyano, nitro, NR.sup.39R.sup.40, OR.sup.41, S(O).sub.nR.sup.42, thiocyanato, isothiocyanato, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, pentafluorothio, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylcarbonyl-(C.sub.1-C.sub.6)-alkyl, COOR.sup.42, CONR.sup.39R.sup.40, COR.sup.41, NOR.sup.41, R.sup.41OOC(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkynyl, heteroaryl-(C.sub.1-C.sub.6)-alkynyl, heterocyclyl-(C.sub.1-C.sub.6)-alkynyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl-(C.sub.2-C.sub.6)-alkynyl, bis[(C.sub.1-C.sub.6)-alkyl](aryl)silyl-(C.sub.2-C.sub.6)-alkynyl, bisaryl [(C.sub.1-C.sub.6)-alkyl]silyl-(C.sub.2-C.sub.6)-alkynyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.2-C.sub.6)-alkynyl, aryl-(C.sub.2-C.sub.6)-alkenyl, heteroaryl-(C.sub.2-C.sub.6)-alkenyl, heterocyclyl-(C.sub.2-C.sub.6)-alkenyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.2-C.sub.6)-alkenyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylaminosulfonylamino, (C.sub.3-C.sub.6)-cycloalkylaminosulfonylamino, diazo, aryldiazo, tris[(C.sub.1-C.sub.6)-alkyl]silyl, bis[(C.sub.1-C.sub.6)-alkyl](aryl)silyl, bisaryl[(C.sub.1-C.sub.6)-alkyl]silyl, X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are the same or different and are independently N (nitrogen) or the CR.sup.2 moiety, but there are never more than two adjacent nitrogen atoms, and where R.sup.2 in each CR.sup.2 moiety is the same or different as defined below, and where R.sup.1 and R.sup.2 are not both hydrogen when X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are CR.sup.2, W is O (oxygen) or S (sulfur), A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 are the same or different and are each independently N (nitrogen) or the CR.sup.38 moiety, but there are never more than two adjacent nitrogen atoms, and where R.sup.38 in each CR.sup.38 moiety is the same or different as defined above, Q together with the CR.sup.3R.sup.4 group and the nitrogen atom to which they are bonded forms a fully saturated, partly saturated or fully unsaturated 3-7-membered ring which is optionally interrupted by heteroatoms and optionally has further substitution, and is additionally the moieties Q-1 to Q-15 ##STR00122## ##STR00123## where R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25, R.sup.26, R.sup.27, R.sup.28, R.sup.29, R.sup.30, R.sup.31, R.sup.32, R.sup.33, R.sup.34, R.sup.35, R.sup.36 and R.sup.37 are each defined according to the definitions above and where the arrow represents a bond to the nitrogen atom of the hydrazide group, R.sup.3, R.sup.4, R.sup.17, R.sup.18, R.sup.19 and R.sup.20 are independently hydrogen, halogen, NR.sup.39R.sup.40, S(O).sub.nR.sup.42, cyano, nitro, cyano-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.10)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-haloalkenyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylamino-(C.sub.1-C.sub.6)-alkyl, bis[(C.sub.1-C.sub.6)-alkyl]amino-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkylamino-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, hydroxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyloxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkynyloxycarbonyl-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylcarbonyl-(C.sub.1-C.sub.6)-alkyl, or together with the atom to which they are bonded form an oxo group, R.sup.5 and R.sup.6 are independently hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, COOR.sup.41, CONR.sup.39R.sup.40, hydroxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyloxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkynyloxycarbonyl-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, heteroaryl-(C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl-(C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25, R.sup.26, R.sup.27, R.sup.28, R.sup.30, R.sup.31, R.sup.32, R.sup.33, R.sup.34, R.sup.35 and R.sup.36 are independently hydrogen, cyano, nitro, halogen, hydroxyl, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-haloalkylthio, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.1-C.sub.10)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-haloalkenyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, R.sup.37 is hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.2-C.sub.6)-alkenyloxy, aryl, heteroaryl, heterocyclyl, COR.sup.41, COOR.sup.41, CONR.sup.39R.sup.40, S(O).sub.nR.sup.42, n is 0, 1 or 2, R.sup.39 and R.sup.40 are the same or different and are independently hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.6)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.6)-alkyl, COR.sup.41, SO.sub.2R.sup.42, (C.sub.1-C.sub.6)-alkyl-HNO.sub.2S, (C.sub.3-C.sub.6)-cycloalkyl-HNO.sub.2S, heterocyclyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl, heteroaryl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.2-C.sub.6)-alkenyloxycarbonyl, (C.sub.2-C.sub.6)-alkynyloxycarbonyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, R.sup.41 is hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.6)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyloxycarbonyl-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, hydroxycarbonyl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl and R.sup.42 is hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.6)-cyanoalkyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.3-C.sub.10)-halocycloalkyl, (C.sub.4-C.sub.10)-cycloalkenyl, (C.sub.4-C.sub.10)-halocycloalkenyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-haloalkyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.4-C.sub.10)-cycloalkenyl-(C.sub.1-C.sub.6)-alkyl, NR.sup.39R.sup.40. Y is a bond or the Y-1 to Y-7 moieties ##STR00124## where R.sup.43, R.sup.44, R.sup.45, R.sup.46, R.sup.47, R.sup.48, R.sup.49, R.sup.50, R.sup.51, R.sup.52, R.sup.53 and R.sup.54 are each as per the definition below and where the arrow represents a bond to the 6-membered ring with the A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 moieties, R.sup.43, R.sup.44, R.sup.45, R.sup.46, R.sup.47, R.sup.48, R.sup.49, R.sup.50, R.sup.51, R.sup.52, R.sup.53 and R.sup.54 are independently hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.10)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.3-C.sub.10)-cycloalkyl, aryl, aryl-(C.sub.1-C.sub.6)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, COOR.sup.23, R.sup.1 and X.sup.1, when X.sup.1 is a CR.sup.2 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, X.sup.1 and X.sup.2, when each is a CR.sup.2 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.1 and A.sup.2, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.2 and A.sup.3, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, A.sup.3 and A.sup.4, when each is a CR.sup.7 group, together with the atoms to which they are bonded form a fully saturated, partly saturated or fully unsaturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.5 and R.sup.6 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.3 and R.sup.23 together with the atoms to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.9 and R.sup.10 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution and R.sup.15 and R.sup.16 together with the atom to which they are bonded form a fully saturated or partly saturated 5-7-membered ring optionally interrupted by heteroatoms and optionally having further substitution.

4. A product comprising one or more compounds of the formula (I) or salts thereof as claimed in claim 1 for increasing tolerance to abiotic stress in plants.

5. A treatment of plants comprising applying a nontoxic amount, effective for enhancing the resistance of plants to one or more abiotic stress factors, one or more of the compounds of formula (I) or salts thereof as claimed in claim 1.

6. The treatment as claimed in claim 5, wherein the abiotic stress conditions correspond to one or more conditions selected from the group of heat, drought, cold and drought stress, osmotic stress, waterlogging, elevated soil salinity, elevated exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients.

7. A product comprising one or more compounds of formula (I) or salts thereof as claimed in claim 1 adapted for use in a spray application to one or more plants and/or plant parts in combinations with one or more active ingredients selected from the group of insecticides, attractants, acaricides, fungicides, nematicides, herbicides, growth regulators, safeners, substances which influence plant maturity and bactericides.

8. A product comprising one or more compounds of formula (I) or salts thereof as claimed in claim 1 adapted for use in a spray application for one or more plants and plant parts in combination with one or more fertilizers.

9. A product comprising one or more compounds of formula (I) or salts thereof as claimed in claim 1 for application to genetically modified cultivars, seed thereof, and/or to cultivated areas in which cultivars grow.

10. A spray solution for treatment of plants, comprising an amount, effective for enhancing the resistance of plants to abiotic stress factors, of one or more compounds of formula (I) as claimed in claim 1 or salts thereof.

11. A product comprising a spray solution comprising one or more compounds of formula (I) as claimed in claim 1 or salts thereof for enhancing the resistance of one or more plants to one or more abiotic stress factors.

12. A method of increasing stress tolerance in one or more plants selected from the group of useful plants, ornamental plants, turfgrass types and trees, which comprises applying a sufficient, nontoxic amount of one or more compounds of formula (I) as claimed in claim 1 or salts thereof to an area where a corresponding effect is desired, to the plants, seed thereof and/or to an area in which plants grow.

13. The method as claimed in claim 12, wherein the resistance of the plants thus treated to abiotic stress is increased by at least 3% compared to untreated plants under otherwise identical physiological conditions.

Description

SYNTHESIS EXAMPLES

No. A1-37: N-(3-Methoxyazetidin-1-yl)-N-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2-(trifluoromethyl)benzamide

[0187] ##STR00025##

[0188] 2-(Trifluoromethyl)benzoyl chloride (530 mg, 2.54 mmol) was dissolved in abs. dichloromethane (10 ml), and triethylamine (1.09 ml, 7.88 mmol) was added. After stirring at room temperature for 5 minutes and then cooling the reaction solution to 0 C., a solution of 3-methoxyazetidin-1-amine oxalate salt (488 mg, 2.54 mmol) in abs. dichloromethane (5 ml) was added dropwise. The resulting reaction mixture was stirred at room temperature for a further 3 h, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(3-methoxyazetidin-1-yl)-2-(trifluoromethyl)benzamide in the form of a colorless solid (110 mg, 16% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.71-7.67 (m, 1H), 7.62-7.48 (m, 3H), 6.80 (br. s, 1H, NH), 4.32-4.28 (m, 1H), 4.08 (m, 1H), 3.82-3.69 (m, 1H), 3.57-3.53 (m, 1H), 3.34-3.30 (m, 1H), 3.30 (s, 3H). N-(3-Methoxyazetidin-1-yl)-2-(trifluoromethyl)benzamide (110 mg, 0.40 mmol) was dissolved in abs. tetrahydrofuran (5 ml) under argon, and sodium hydride (24 mg, 0.60 mmol, 60% dispersion) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2-(chloromethyl)-3,5-dimethyl-4-methoxypyridine (102 mg, 0.55 mmol), and the resulting reaction mixture was stirred under reflux conditions for 3 hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(3-methoxyazetidin-1-yl-N-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2-(trifluoromethyl)benzamide in the form of a colorless solid (21 mg, 9% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.30 (s, 1H), 7.62 (m, 1H), 7.53 (m, 1H), 7.47 (m, 1H), 7.39 (m, 1H), 5.24-5.19 (m, 2H), 4.89 (s, 2H), 4.43-4.38 (m, 2H), 3.80 (s, 3H), 3.68 (m, 1H), 3.23 (s, 3H), 2.50 (s, 3H), 2.31 (s, 3H).

No. A2-122: N-Quinolin-2-yl)methyl]-N-(pyrrolidin-1-yl)-2-(trifluoromethyl)benzamide

[0189] ##STR00026##

[0190] 2-(Trifluoromethyl)benzoyl chloride (3000 mg, 14.38 mmol) was dissolved in abs. dichloromethane (40 ml), and triethylamine (2.41 ml, 17.26 mmol) was added. After stirring at room temperature for 5 minutes and then cooling the reaction solution to 0 C., a solution of 1-aminopyrrolidine (1239 mg, 14.38 mmol) in abs. dichloromethane (10 ml) was added dropwise. The resulting reaction mixture was stirred at room temperature for a further 3 h, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(pyrrolidin-1-yl)-2-(trifluoromethyl)benzamide in the form of a colorless solid (2160 mg, 52% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.71-7.67 (m, 1H), 7.62-7.48 (m, 3H), 6.41 (br. s, 1H, NH), 3.5-3.00 (m, 4H), 1.96-1.89 (m, 4H). N-(Pyrrolidin-1-yl)-2-(trifluoromethyl)benzamide (1000 mg, 3.87 mmol) was dissolved in abs. tetrahydrofuran (15 ml) under argon, and sodium hydride (170 mg, 4.26 mmol, 60% dispersion) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2-(chloromethyl)quinoline (1 equiv., 3.87 mmol), and the resulting reaction mixture was stirred under reflux conditions for 5 hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(quinolin-2-ylmethyl)-N-(pyrrolidin-1-yl)-2-(trifluoromethyl)benzamide in the form of a colorless solid (327 mg, 20% of theory). .sup.1H-NMR (400 MHz, CDCL.sub.3 , ppm) 8.25 (m, 1H), 8.08 (m, 1H), 7.87-7.83 (m, 2H), 7.77-7.74 (m, 1H), 7.61-7.57 (m, 2H), 7.44-7.38 (m, 2H), 7.36-7.32 (m, 1H), 5.46 (s, 2H), 4.33-4.28 (m, 2H), 3.79-3.71 (m, 2H), 2.38-2.29 (m, 2H), 2.14-2.06 (m, 2H).

No. A3-21: N-(3-Methoxypyrrolidin-1-yl)-N-(pyridin-2-ylmethyl)-2-(trifluoromethyl)benzamide

[0191] ##STR00027##

[0192] 2-(Trifluoromethyl)benzoyl chloride (550 mg, 2.64 mmol) was dissolved in abs. dichloromethane (10 ml), and triethylamine (0.44 ml, 3.16 mmol) was added. After stirring at room temperature for 5 minutes and then cooling the reaction solution to 0 C., a solution of 3-methoxypyrrolidin-1-amine (306 mg, 2.64 mmol) in abs. dichloromethane (5 ml) was added dropwise. The resulting reaction mixture was stirred at room temperature for 3 h, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(3-methoxypyrrolidin-1-yl)-2-(trifluoromethyl)benzamide in the form of a colorless solid (580 mg, 76% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.70-7.67 (m, 1H), 7.60-7.53 (m, 3H), 7.11 (br. s, 1H, NH), 4.04-3.99 (m, 1H), 3.42-3.38 (m, 1H), 3.36-3.32 (m, 1H), 3.29 (s, 3H), 3.12-3.01 (m, 2H), 2.92 (m, 1H), 2.15-2.09 (m, 1H), 2.03-1.96 (m, 1H). N-(3-Methoxypyrrolidin-1-yl)-2-(trifluoromethyl)benzamide (150 mg, 0.52 mmol) was dissolved in abs. tetrahydrofuran (5 ml) under argon, and sodium hydride (23 mg, 0.57 mmol, 60% dispersion) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2-chloromethylpyrridine (66 mg, 0.52 mmol), and the resulting reaction mixture was stirred under reflux conditions for 3 hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(3-methoxypyrrolidin-1-yl)-N-(pyridin-2-ylmethyl)-2-(trifluoromethyl)benzamide in the form of a colorless solid (54 mg, 27% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.65 (m, 1H), 7.77-7.74 (m, 1H), 7.72-7.70 (m, 1H), 7.60-7.58 (m, 1H), 7.42-7.38 (m, 1H), 7.36-7.32 (m, 2H), 7.24 (m, 1H), 5.53 (d, 1H), 5.16 (d, 1H), 4.53-4.47 (m, 1H), 4.26-4.17 (m, 2H), 3.94-3.85 (m, 2H), 3.35 (s, 3H), 2.63-2.57 (m, 1H), 2.15-2.09 (m, 1H).

No. A10-36: N-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-2,6-difluoro-N-(pyrrolidin-1-yl)benzamide

[0193] ##STR00028##

[0194] 2,6-Difluorobenzoic acid (1 equiv.) was dissolved in abs. dichloromethane (10 ml/mmol), and triethylamine (3 equiv.) was added. After stirring at room temperature for 5 minutes, 1-aminopyrrolidine (1.3 equiv.) and 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (1.5 equiv., 50% solution in tetrahydrofuran) were added. The resulting reaction mixture was stirred at room temperature for a further 30 minutes, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave 2,6-difluoro-N-(pyrrolidin-1-yl)benzamide in the form of a colorless solid. 2,6-Difluoro-N-(pyrrolidin-1-yl)benzamide (100 mg, 0.44 mmol) was then dissolved in abs. N,N-dimethylformamide (10 ml) under argon, and potassium carbonate (122 mg, 0.88 mmol) and catalytic amounts of potassium iodide were added at room temperature. Stirring at room temperature for 15 minutes was followed by the addition of 3-chloro-2-(chloromethyl)-5-(trifluoromethyl)pyridine (122 mg, 0.53 mmol), and the resulting reaction mixture was stirred under reflux conditions for two hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-2,6-difluoro-N-(pyrrolidin-1-yl)benzamide in the form of a colorless viscous oil (119 mg, 64% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.82 (m, 1H), 8.03 (m, 1H), 7.17-7.10 (m, 1H), 6.82-6.75 (m, 2H), 5.61 (s, 2H), 4.70-4.65 (m, 2H), 3.58-3.51 (m, 2H), 2.42-2.35 (m, 2H), 2.08-2.01 (m, 2H).

No. A12-21: N(N-Methylpyridazin-1-yl)-N-(pyridin-2-ylmethyl)-2-(trifluoromethyl)-benzamide

[0195] ##STR00029##

[0196] 2-(Trifluoromethyl)benzoic acid (600 mg, 3.16 mmol) was dissolved in abs. dichloromethane (5 ml), and triethylamine (1.32 ml, 9.47 mmol) was added. After stirring at room temperature for 5 minutes, 4-methylpiperazin-1-amine (436 mg, 3.79 mmol) and 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (2.44 ml, 410 mmol, 50% solution in tetrahydrofuran) were added. The resulting reaction mixture was stirred at room temperature for a further 30 minutes, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave 2-trifluoromethyl-N-(4-methylpiperazin-1-yl)benzamide in the form of a colorless solid (500 mg, 47% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.72 (m, 1H), 7.61-7.53 (m, 3H), 6.78 (br. s, 1H, NH), 3.78-3.73 (m, 2H), 3.14-3.02 (m, 4H), 2.82-2.71 (m, 2H), 2.41 (s, 3H). 2-Trifluoromethyl-N-(4-methylpiperazin-1-yl)benzamine (175 mg, 0.55 mmol) was dissolved in abs. tetrahydrofuran (4 ml) under argon, and sodium hydride (57 mg, 1.43 mmol, 60% dispersion) was added at room temperature. Stirring at room temperature for 20 minutes was followed by the addition of 2-picolyl chloride hydrochloride (90 mg, 0.55 mmol), and the resulting reaction mixture was stirred at a temperature of 70 C. for 4 hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N(N-methylpyridazin-1-yl)-N-(pyridin-2-ylmethyl)-2-(trifluoromethyl)benzamide in the form of a colorless solid (58 mg, 28% of theory). .sup.1H-NMR (400 MHz, d.sub.6-DMSO , ppm) 8.68 (m, 1H), 7.90 (m, 1H), 7.74-7.68 (m, 1H), 7.61-7.58 (m, 1H), 7.51-7.37 (m, 3H), 7.15 (m, 1H), 5.16 (s, 2H), 4.26-4.15 (m, 2H), 3.54-3.39 (m, 4H), 2.92-2.83 (m, 2H), 2.43 (s, 3H).

No. A14-4: N-(Pyrrolidin-1-yl)-N-(2,3-dichlorobenzyl)-4-(1,2,3-benzothiadiazolyl)carbonyl amide

[0197] ##STR00030##

[0198] 4-(1,2,3-benzothiadiazolyl)carboxylic acid (800 mg, 4.44 mmol) was dissolved in abs. dichloromethane (30 ml) in a baked-out round-bottom flask under argon and at room temperature, and triethylamine (1.86 ml, 13.32 mmol) was added. After stirring at room temperature for 5 minutes, 1-aminopyrrolidine (459 mg, 5.33 mmol) and 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (1.98 ml, 6.66 mmol, 50% solution in tetrahydrofuran) were added. The resulting reaction mixture was stirred at room temperature for a further 60 minutes, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-pyrrolidinyl-4-(1,2,3-benzothiadiazolyl)carbonyl hydrazide in the form of a colorless solid (310 mg, 28% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.73 (m, 1H), 7.99 (m, 1H), 7.71 (m, 1H), 7.42 (br. s, 1H, NH), 3.81 (m, 4H), 2.03 (m, 4H). N-Pyrrolidinyl-4-(1,2,3-benzothiadiazolyl)carbonyl hydrazide (80 mg, 0.32 mmol) was dissolved in abs. tetrahydrofuran (5 ml) under argon, and sodium hydride (15 mg, 0.39 mmol, 60% purity) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2,3-dichlorobenzyl chloride (66 mg, 0.34 mmol), and the resulting reaction mixture was stirred under reflux conditions for two-and-a-half hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(pyrrolidin-1-yl) N-(2,3-dichlorobenzyl)-4-(1,2,3-benzothiadiazolyl)carbonyl amide in the form of a colorless solid (96 mg, 73% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.65 (m, 1H), 8.39 (m, 1H), 7.69 (m, 1H), 7.48 (m, 1H), 7.37 (m, 1H), 7.05 (m, 1H), 5.48 (s, 2H), 4.40 (m, 2H), 3.51 (m, 2H), 2.37 (m, 2H), 2.12 (m, 2H).

No. B2-1: N-(2-Chlorobenzyl)-N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide

[0199] ##STR00031##

[0200] 4-(Trifluoromethyl)nicotinic acid (1100 mg, 5.25 mmol) was dissolved in abs. dichloromethane (30 ml) in a baked-out round-bottom flask under argon and at room temperature, and oxalyl chloride (0.39 ml, 4.45 mmol) and catalytic amounts of N,N-dimethyl-formamide were added. The resulting reaction solution was then stirred at room temperature for 3 h and under reflux conditions for 1 h. After cooling to room temperature, the reaction mixture was concentrated and coevaporated with a little abs. toluene. By thorough removal of solvent residues, 4-(trifluoromethyl)nicotinoyl chloride (1100 mg, 5.25 mmol) was obtained, which was then, without further purification, dissolved again in abs. dichloromethane (10 ml) and added dropwise to a solution, cooled to 0 C., of 1-aminopyrrolidine HCl salt (715 mg, 5.25 mmol) and triethylamine (1.61 ml, 11.55 mmol) in dichloromethane (5 ml) under argon. The resulting reaction mixture was stirred at room temperature for 1.5 h, and then water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide in the form of a colorless solid (360 mg, 26% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.86 (m, 1H), 8.70 (m, 1H), 7.58 (m, 1H), 6.59 (br. s, 1H, NH), 3.09 (m, 4H), 2.78 (m, 4H). N-(Pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide (100 mg, 0.39 mmol) was dissolved in abs. tetrahydrofuran (6 ml) under argon, and sodium hydride (17 mg, 0.42 mmol, 60% purity) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2-chlorobenzyl chloride (62 mg, 0.39 mmol), and the resulting reaction mixture was stirred under reflux conditions for two-and-a-half hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(2-chlorobenzyl)-N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide in the form of a colorless solid (82 mg, 55% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.89 (m, 1H), 8.71 (m, 1H), 7.80-7.77 (m, 1H), 7.53-7.48 (m, 2H), 7.42-7.38 (m, 2H), 5.39 (s, 2H), 4.33-4.28 (m, 2H), 3.45-3.38 (m, 2H), 2.39-2.30 (m, 2H), 2.09-2.03 (m, 2H).

No. B2-61: N-(2-Cyanobenzyl)-N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide

[0201] ##STR00032##

[0202] 6-(Trifluoromethyl)nicotinic acid (1100 mg, 5.25 mmol) was dissolved in abs. dichloromethane (30 ml) in a baked-out round-bottom flask under argon and at room temperature, and oxalyl chloride (0.39 ml, 4.45 mmol) and catalytic amounts of N,N-dimethylformamide were added. The resulting reaction solution was then stirred at room temperature for 3 h and under reflux conditions for 1 h. After cooling to room temperature, the reaction mixture was concentrated and coevaporated with a little abs. toluene. By thorough removal of solvent residues, 4-(trifluoromethyl)nicotinoyl chloride (1100 mg, 5.25 mmol) was obtained, which was then, without further purification, dissolved again in abs. dichloromethane (10 ml) and added dropwise to a solution, cooled to 0 C., of 1-aminopyrrolidine HCl salt (715 mg, 5.25 mmol) and triethylamine (1.61 ml, 11.55 mmol) in dichloromethane (5 ml) under argon. The resulting reaction mixture was stirred at room temperature for 1.5 h, and then water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide in the form of a colorless solid (360 mg, 26% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.86 (m, 1H), 8.70 (m, 1H), 7.58 (m, 1H), 6.59 (br. s, 1H, NH), 3.09 (m, 4H), 2.78 (m, 4H). N-(Pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide (100 mg, 0.39 mmol) was dissolved in abs. tetrahydrofuran (6 ml) under argon, and sodium hydride (17 mg, 0.42 mmol, 60% purity) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2-chloromethylbenzonitrile (58 mg, 0.39 mmol), and the resulting reaction mixture was stirred under reflux conditions for two-and-a-half hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(2-cyanobenzyl)-N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide in the form of a colorless solid (88 mg, 61% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.83 (m, 1H), 8.69 (m, 1H), 7.97 (m, 1H), 7.76-7.70 (m, 2H), 7.58 (m, 1H), 7.52 (m, 1H), 5.42 (s, 2H), 4.29-4.23 (m, 2H), 3.54-3.47 (m, 2H), 2.39-2.30 (m, 2H), 2.20-2.13 (m, 2H).

No. B2-144: N-{[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}-N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide

[0203] ##STR00033##

[0204] N-(Pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide (100 mg, 0.39 mmol) was dissolved in abs. tetrahydrofuran (6 ml) under argon, and sodium hydride (17 mg, 0.42 mmol, 60% purity) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2-(chloromethyl)-3-methyl-4(2,2,2-trifluoroethoxy)pyridine (95 mg, 0.39 mmol), and the resulting reaction mixture was stirred under reflux conditions for two-and-a-half hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-{[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}-N-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinamide in the form of a colorless solid (138 mg, 77% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.74 (m, 1H), 8.67 (m, 1H), 8.44 (m, 1H), 7.47 (m, 1H), 6.76 (m, 1H), 5.35 (s, 2H), 4.48-4.38 (m, 4H), 3.66-3.59 (m, 2H), 2.52 (s, 3H), 2.34-2.27 (m, 2H), 1.98-1.90 (m, 2H).

No. B5-61: N-(2-Cyanobenzyl)-N-(morpholin-4-yl)-4-(trifluoromethyl)-nicotinamide

[0205] ##STR00034##

[0206] 4-(Trifluoromethyl)nicotinic acid (1000 mg, 5.23 mmol) was dissolved in abs. dichloromethane (10 ml/mmol), and triethylamine (2.19 ml, 15.69 mmol) was added. After stirring at room temperature for 5 minutes, 4-aminomorpholine (641 mg, 6.28) and 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (4328 mg, 6.80 mmol, 50% solution in tetrahydrofuran) were added. The resulting reaction mixture was stirred at room temperature for a further 30 minutes, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(morpholinyl-4-yl)-4-(trifluoromethyl)nicotinamide in the form of a colorless solid (530 mg, 37% of theory). N-(morpholin-4-yl)-4-(trifluoromethyl)nicotinamide (200 mg, 0.73 mmol) was dissolved in a mixture of abs. tetrahydrofuran and abs. N,N-dimethylformamide (5 ml, 4:1) under argon, and sodium hydride (41 mg, 1.02 mmol, 60% purity) was added at room temperature. Stirring at room temperature for 30 minutes was followed by the addition of 2-bromomethylbenzonitrile (143 mg, 0.73 mmol) and sodium iodide (22 mg, 0.15 mmol), and the resulting reaction mixture was stirred at a temperature of 70 C. for four hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(2-cyanobenzyl)-N-(morpholin-4-yl)-4-(trifluoromethyl)-nicotinamide in the form of a colorless solid (93 mg, 33% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.87 (m, 1H), 8.74 (m, 1H), 7.90 (m, 1H), 7.80 (m, 1H), 7.75-7.71 (m, 1H), 7.64-7.59 (m, 1H), 7.57 (m, 1H), 5.41 (s, 2H), 4.32-4.26 (m, 4H), 3.90-3.83 (m, 2H), 3.46-3.39 (m, 2H).

No. B8-462: 2-Chloro-N-[3-(2,6-difluorophenyl)propyl]-N-(pyrrolidin-1-yl)nicotinamide

[0207] ##STR00035##

[0208] 2-Chloronicotinic acid (1 equiv.) was dissolved in abs. dichloromethane (10 ml/mmol), and triethylamine (3 equiv.) was added. After stirring at room temperature for 5 minutes, 1-aminopyrrolidine (1.3 equiv.) and 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (1.5 equiv., 50% solution in tetrahydrofuran) were added. The resulting reaction mixture was stirred at room temperature for a further 30 minutes, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave 2-chloro-N-(pyrrolidin-1-yl)nicotinamide in the form of a colorless solid. 2-Chloro-N-(pyrrolidin-1-yl)nicotinamide (180 mg, 0.79 mmol) was then dissolved in abs. N,N-dimethylformamide (10 ml) under argon, and sodium hydride (38 mg, 0.95 mmol, 60% purity) was added at room temperature. Stirring at room temperature for 15 minutes was followed by the addition of 2-(3-bromopropyl)-1,3-difluorobenzene (225 mg, 0.95 mmol), and the resulting reaction mixture was stirred at a temperature of 80 C. for two hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-[3-(2,6-difluorophenyl)propyl]-N-(pyrrolidin-1-yl)-3-(trifluoromethyl)pyridine-2-carboxamide in the form of a colorless viscous oil (109 mg, 34% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.28 (m, 1H), 7.71 (m, 1H), 7.19-7.10 (m, 2H), 6.89-6.80 (m, 2H), 4.42-4.35 (m, 2H), 4.05-3.98 (m, 2H), 3.19-3.12 (m, 2H), 2.86-2.76 (m, 4H), 2.39-2.29 (m, 2H), 2.26-2.15 (m, 2H).

No. D1-462: N-[3-(2,6-Difluorophenyl)propyl]-N-(pyrrolidin-1-yl)-3-(trifluoromethyl)pyridine-2-carboxamide

[0209] ##STR00036##

[0210] 3-(Trifluoromethyl)pyridine-2-carboxylic acid (1 equiv.) was dissolved in abs. dichloromethane (10 ml/mmol), and triethylamine (3 equiv.) was added. After stirring at room temperature for 5 minutes, 1-aminopyrrolidine (1.3 equiv.) and 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (1.5 equiv. 50% solution in tetrahydrofuran) were added. The resulting reaction mixture was stirred at room temperature for a further 30 minutes, and then water, sat. sodium hydrogencarbonate solution and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-(pyrrolidin-1-yl)-3-(trifluoromethyl)pyridine-2-carboxamide in the form of a colorless solid. N-(Pyrrolidin-1-yl)-3-(trifluoromethyl)pyridine-2-carboxamide (200 mg, 0.7 mmol) was then dissolved in abs. N,N-dimethylformamide (10 ml) under argon, and sodium hydride (50 mg, 1.16 mmol, 60% purity) was added at room temperature. Stirring at room temperature for 15 minutes was followed by the addition of 2-(3-bromopropyl)-1,3-difluorobenzene (218 mg, 0.93 mmol), and the resulting reaction mixture was stirred at a temperature of 80 C. for two hours. After cooling to room temperature, sat. sodium hydrogencarbonate solution, water and dichloromethane were added. The aqueous phase was repeatedly extracted vigorously with dichloromethane, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification of the resulting crude product by column chromatography gave N-[3-(2,6-difluorophenyl)propyl]-N-(pyrrolidin-1-yl)-3-(trifluoromethyl)pyridine-2-carboxamide in the form of a colorless viscous oil (109 mg, 34% of theory). .sup.1H-NMR (400 MHz, CDCl.sub.3 6, ppm) 8.79 (d, 1H), 8.05 (m, 1H), 7.54-7.50 (m, 1H), 7.25-7.14 (m, 2H), 6.91-6.84 (m, 1H), 4.81-4.75 (m, 2H), 4.05-3.98 (m, 2H), 3.55-3.47 (m, 2H), 2.86-2.82 (m, 2H), 2.53-2.43 (m, 2H), 2.38-2.29 (m, 2H), 2.22-2.15 (m, 2H).

[0211] In analogy to the preparation examples cited above and recited at the appropriate point, and taking account of the general details relating to the preparation of substituted heteroarylcarbonyl hydrazides of the general formula (I), the compounds cited below are obtained. In table 1 below, Y= represents a direct bond.

[0212] A1. Compounds A1-1 to A1-681 of the general formula (Ic1) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 670; corresponding to compounds A1-1 to A1-681) in table 1 below.

##STR00037##

TABLE-US-00001 TABLE 1 No. R.sup.5 R.sup.6 Y A.sup.1 A.sup.2 A.sup.3 A.sup.4 A.sup.5 1 H H CCl CH CH CH CH 2 H H CH CCl CH CH CH 3 H H CH CH CCl CH CH 4 H H CCl CCl CH CH CH 5 H H CCl CH CCl CH CH 6 H H CCl CH CH CCl CH 7 H H CCl CH CH CH CCl 8 H H CH CCl CCl CH CH 9 H H CH CCl CH CCl CH 10 H H CCl CH CCl CH CCl 11 H H CF CH CH CH CH 12 H H CH CF CH CH CH 13 H H CH CH CF CH CH 14 H H CF CF CH CH CH 15 H H CF CH CF CH CH 16 H H CF CH CH CF CH 17 H H CF CH CH CH CF 18 H H CH CF CF CH CH 19 H H CH CF CH CF CH 20 H H CF CH CF CH CF 21 H H N CH CH CH CH 22 H H CH N CH CH CH 23 H H CH CH N CH CH 24 H H N N CH CH CH 25 H H N CH N CH CH 26 H H N CH CH N CH 27 H H N CH CH CH N 28 H H CH N N CH CH 29 H H CH N CH N CH 30 H H N COCH.sub.3 CH COCH.sub.3 N 31 H H N CCl CH CH CH 32 H H N CH CCl CH CH 33 H H N CH CH CCl CH 34 H H N CH CH CH CCl 35 H H N CH CCl CH CCl 36 H H N CH CCF.sub.3 CH CCl 37 H H N CH CCH.sub.3 COCH.sub.3 CCH.sub.3 38 H H N CH CH CH CCH.sub.3 39 H H N CH CH CCH.sub.3 CH 40 H H N CH CH CCl CCl 41 H H CBr CH CH CH CH 42 H H CH CBr CH CH CH 43 H H CH CH CBr CH CH 44 H H CF CH CBr CH CH 45 H H CCl CH CBr CH CH 46 H H CBr CH CF CH CH 47 H H CBr CH CCl CH CH 48 H H CH CCl CBr CH CH 49 H H CH CBr CCl CH CH 50 H H CH N CH CBr CH 51 H H CI CH CH CH CH 52 H H CH CI CH CH CH 53 H H CH CH CI CH CH 54 H H CF CH CI CH CH 55 H H CF CH CCl CH CH 56 H H CF CH CH CCl CH 57 H H CH CF CCl CH CH 58 H H CH CCl CF CH CH 59 H H CF CH CH CH CCl 60 H H CH CF CH CCl CH 61 H H CCN CH CH CH CH 62 H H CH CCN CH CH CH 63 H H CH CH CCN CH CH 64 H H CCl CH CCN CH CH 65 H H CH CCl CH CCN CH 66 H H COEt CH CH CH CH 67 H H CH COEt CH CH CH 68 H H CH CH COEt CH CH 69 H H CCl CH COEt CH CH 70 H H CH CCl CH COEt CH 71 H H CCH.sub.3 CH CH CH CH 72 H H CH CCH.sub.3 CH CH CH 73 H H CH CH CCH.sub.3 CH CH 74 H H CCH.sub.3 CCH.sub.3 CH CH CH 75 H H CCH.sub.3 CH CCH.sub.3 CH CH 76 H H CCH.sub.3 CH CH CCH.sub.3 CH 77 H H CCH.sub.3 CH CH CH CCH.sub.3 78 H H CH CCH.sub.3 CCH.sub.3 CH CH 79 H H CH CCH.sub.3 CH CCH.sub.3 CH 80 H H CCH.sub.3 CH CCH.sub.3 CH CCH.sub.3 81 H H CCF.sub.3 CH CH CH CH 82 H H CH CCF.sub.3 CH CH CH 83 H H CH CH CCF.sub.3 CH CH 84 H H CCF.sub.3 CCl CH CH CH 85 H H CCF.sub.3 CH CCF.sub.3 CH CH 86 H H CCl CH CH CCF.sub.3 CH 87 H H CCl CH CH CH CCF.sub.3 88 H H CH CCF.sub.3 CCF.sub.3 CH CH 89 H H CH CCF.sub.3 CH CCF.sub.3 CH 90 H H CCl CH CCl CH CCF.sub.3 91 H H CCl CH CCF.sub.3 CH CH 92 H H CCF.sub.3 CH CCl CH CH 93 H H CH CCl CCF.sub.3 CH CH 94 H H CH N CCl CH CH 95 H H CH N CF CH CH 96 H H CH N CCF.sub.3 CH CH 96 H H CH N CH CCF.sub.3 CH 97 H H CCl N CH CH CH 98 H H CH N CH CCl CH 99 H H CCl N CCl CH CH 100 H H CCl N CH CH CCl 101 H H COCH.sub.3 CH CH CH CH 102 H H CH COCH.sub.3 CH CH CH 103 H H CH CH COCH.sub.3 CH CH 104 H H COCH.sub.3 COCH.sub.3 CH CH CH 105 H H COCH.sub.3 CH COCH.sub.3 CH CH 106 H H COCH.sub.3 CH CH COCH.sub.3 CH 107 H H COCH.sub.3 CH CH CH CCl 108 H H CH COCH.sub.3 COCH.sub.3 CH CH 109 H H CH COCH.sub.3 CH COCH.sub.3 CH 110 H H CH COCH.sub.3 COCH.sub.3 COCH.sub.3 CH 101 H H CSCH.sub.3 CH CH CH CH 102 H H CH CSCH.sub.3 CH CH CH 103 H H CH CH CSCH.sub.3 CH CH 104 H H CSCF.sub.3 CH CH CH CH 105 H H CH CSCF.sub.3 CH CH CH 106 H H CH CH CSCF.sub.3 CH CH 107 H H COCF.sub.3 CH CH CH CH 108 H H CH COCF.sub.3 CH CH CH 109 H H CH CH COCF.sub.3 CH CH 110 H H CNO.sub.2 CH CH CH CH 111 H H CH CNO.sub.2 CH CH CH 112 H H CH CH CNO.sub.2 CH CH 113 H H CCl CH CNO.sub.2 CH CH 114 H H CCl CH COCH.sub.3 CH CH 115 H H CH CCl COCH.sub.3 CH CH 116 H H CSCN CH CH CH CH 117 H H CH CSCN CH CH CH 118 H H CH CH CSCN CH CH 119 H H CH N CCH.sub.3 CH CH 120 H H CH N COCH.sub.3 CH CH 121 H H N CH [00038] CH 122 H H N [00039] CH CH 123 H H CH N COCH.sub.3 CH CH 124 H H CH N CSCH.sub.3 CH CH 125 H H CH N COCF.sub.3 CH CH 126 H H CEt CH CEt CH CCH.sub.3 127 H H CEt CH CEt CH CH 128 H H CH CH CEt CH CH 129 H H CH CH Ci-Pr CH CH 130 H H [00040] CH CH N 131 H H CH CCl N CH CH 132 H H CCl CH N CH CH 133 H H CH CCl N CCl CH 134 H H CCl N N CCl CH 135 H H CCl CH N CH CCl 136 H H CH CH CH CH CH 137 H H CCl CH CF CH CH 138 H H CCl CH CCl CCl CH 139 H H CCl CH [00041] CH 140 H H CH CH [00042] CH 141 H H CH CH [00043] CH 142 H H [00044] CH CH 143 H H CH CH Ct-Bu CH CH 144 H H N CH CH COCH.sub.2CF.sub.3 CCH.sub.3 145 H H N CH CCH.sub.3 COCH.sub.3 CCH.sub.3 146 H H N CH CH COCH.sub.3 CH 147 H H CCl CH COCH.sub.3 COCH.sub.3 CH 148 H H N CH CH CCl COCH.sub.3 149 H H CCl CH CH CCl CCl 150 H H CH CCl CCl CCl CH 151 CH.sub.3 H CH CH CH CH CH 152 CH.sub.3 H CCl CH CH CH CH 153 CH.sub.3 H CH CCl CH CH CH 154 CH.sub.3 H CH CH CCl CH CH 155 CH.sub.3 H CCl CH CCl CH CH 156 CH.sub.3 H CCl CH CH CCl CH 157 CH.sub.3 H CF CH CH CH CH 158 CH.sub.3 H CH CF CH CH CH 159 CH.sub.3 H CH CH CF CH CH 160 CH.sub.3 H CF CH CF CH CH 161 CH.sub.3 H CH CF CH CF CH 162 CH.sub.3 H CF CH CH CH CF 163 CH.sub.3 H CBr CH CH CH CH 164 CH.sub.3 H CH CBr CH CH CH 165 CH.sub.3 H CH CH CBr CH CH 166 CH.sub.3 H CI CH CH CH CH 167 CH.sub.3 H COCH.sub.3 CH CH CH CH 168 CH.sub.3 H CCF.sub.3 CH CH CH CH 169 CH.sub.3 H CCH.sub.3 CH CH CH CH 170 CH.sub.3 H CCN CH CH CH CH 171 CH.sub.3 H CH CH CI CH CH 172 CH.sub.3 H CH CH COCH.sub.3 CH CH 173 CH.sub.3 H CH CH CCF.sub.3 CH CH 174 CH.sub.3 H CH CH CCH.sub.3 CH CH 175 CH.sub.3 H CH CH CCN CH CH 176 CH.sub.3 H CH CH CSCF.sub.3 CH CH 177 CH.sub.3 H CH CH COCF.sub.3 CH CH 178 CH.sub.3 H CH CH COEt CH CH 179 CH.sub.3 H CH CH Ct-Bu CH CH 180 CH.sub.3 H CF CH CBr CH CH 181 CH.sub.3 H N CH CH CH CH 182 CH.sub.3 H N CCl CH CH CH 183 CH.sub.3 H N CH CCl CH CH 184 CH.sub.3 H N CH CH CH CCl 185 CH.sub.3 H CH N CH CH CH 186 CH.sub.3 H CH N CCl CH CH 187 CH.sub.3 H CH CH N CH CH 188 CH.sub.3 H N CH CH CH N 189 CH.sub.3 H N CH CCF.sub.3 CH CH 190 CH.sub.3 H CCl CH N CH CH 191 CH.sub.3 H CH CI CH CH CH 192 CH.sub.3 H CH COCH.sub.3 CH CH CH 193 CH.sub.3 H CH CCF.sub.3 CH CH CH 194 CH.sub.3 H CH CCH.sub.3 CH CH CH 195 CH.sub.3 H CH CCN CH CH CH 196 CH.sub.3 H CH CCH.sub.3 CH CH CH 197 CH.sub.3 H CH CCl CH CCl CH 198 CH.sub.3 H CH CSCF.sub.3 CH CH CH 199 CH.sub.3 H CH COCF.sub.3 CH CH CH 200 CH.sub.3 H CH COEt CH CH CH 201 Et H CH CH CH CH CH 202 Et H CCl CH CH CH CH 203 Et H CH CCl CH CH CH 204 Et H CH CH CCl CH CH 205 Et H CCl CH CCl CH CH 206 Et H CCl CH CH CCl CH 207 Et H CF CH CH CH CH 208 Et H CH CF CH CH CH 209 Et H CH CH CF CH CH 210 Et H CF CH CF CH CH 211 Et H CH CF CH CF CH 212 Et H CF CH CH CH CF 213 Et H CBr CH CH CH CH 214 Et H CH CBr CH CH CH 215 Et H CH CH CBr CH CH 216 Et H CI CH CH CH CH 217 Et H COCH.sub.3 CH CH CH CH 218 Et H CCF.sub.3 CH CH CH CH 219 Et H CCH.sub.3 CH CH CH CH 220 Et H CCN CH CH CH CH 221 Et H CH CH CI CH CH 222 Et H CH CH COCH.sub.3 CH CH 223 Et H CH CH CCF.sub.3 CH CH 224 Et H CH CH CCH.sub.3 CH CH 225 Et H CH CH CCN CH CH 226 Et H CH CH CSCF.sub.3 CH CH 227 Et H CH CH COCF.sub.3 CH CH 228 Et H CH CH COEt CH CH 229 Et H CH CH Ct-Bu CH CH 230 Et H CF CH CBr CH CH 231 Et H N CH CH CH CH 232 Et H N CCl CH CH CH 233 Et H N CH CCl CH CH 234 Et H N CH CH CH CCl 235 Et H CH N CH CH CH 236 Et H CH N CCl CH CH 237 Et H CH CH N CH CH 238 Et H N CH CH CH N 239 Et H N CH CH N CH 240 Et H CCl CH N CH CH 241 Et H CH CI CH CH CH 242 Et H CH COCH.sub.3 CH CH CH 243 Et H CH CCF.sub.3 CH CH CH 244 Et H CH CCH.sub.3 CH CH CH 245 Et H CH CCN CH CH CH 246 Et H CH CCH.sub.3 CH CH CH 247 Et H CH CCl CH CCl CH 248 Et H CH CSCF.sub.3 CH CH CH 249 Et H CH COCF.sub.3 CH CH CH 250 Et H CH COEt CH CH CH 251 i-Pr H CH CH CH CH CH 252 i-Pr H CCl CH CH CH CH 253 i-Pr H CH CCl CH CH CH 254 i-Pr H CH CH CCl CH CH 255 i-Pr H CCl CH CCl CH CH 256 i-Pr H CCl CH CH CCl CH 257 i-Pr H CF CH CH CH CH 258 i-Pr H CH CF CH CH CH 259 i-Pr H CH CH CF CH CH 260 i-Pr H CF CH CF CH CH 261 i-Pr H CH CF CH CF CH 262 i-Pr H CF CH CH CH CF 263 i-Pr H CBr CH CH CH CH 264 i-Pr H CH CBr CH CH CH 265 i-Pr H CH CH CBr CH CH 266 i-Pr H CI CH CH CH CH 267 i-Pr H COCH.sub.3 CH CH CH CH 268 i-Pr H CCF.sub.3 CH CH CH CH 269 i-Pr H CCH.sub.3 CH CH CH CH 270 i-Pr H CCN CH CH CH CH 271 i-Pr H CH CH CI CH CH 272 i-Pr H CH CH COCH.sub.3 CH CH 273 i-Pr H CH CH CCF.sub.3 CH CH 274 i-Pr H CH CH CCH.sub.3 CH CH 275 i-Pr H CH CH CCN CH CH 276 i-Pr H CH CH CSCF.sub.3 CH CH 277 i-Pr H CH CH COCF.sub.3 CH CH 278 i-Pr H CH CH COEt CH CH 279 i-Pr H CH CH Ct-Bu CH CH 280 i-Pr H CF CH CBr CH CH 281 i-Pr H N CH CH CH CH 282 i-Pr H N CCl CH CH CH 283 i-Pr H N CH CCl CH CH 284 i-Pr H N CH CH CH CCl 285 i-Pr H CH N CH CH CH 286 i-Pr H CH N CCl CH CH 287 i-Pr H CH CH N CH CH 288 i-Pr H N CH CH CH N 289 i-Pr H N CH CH N CH 290 i-Pr H CCl CH N CH CH 291 i-Pr H CH CI CH CH CH 292 i-Pr H CH COCH.sub.3 CH CH CH 293 i-Pr H CH CCF.sub.3 CH CH CH 294 i-Pr H CH CCH.sub.3 CH CH CH 295 i-Pr H CH CCN CH CH CH 296 i-Pr H CH CCH.sub.3 CH CH CH 297 i-Pr H CH CCl CH CCl CH 298 i-Pr H CH CSCF.sub.3 CH CH CH 299 i-Pr H CH COCF.sub.3 CH CH CH 300 i-Pr H CH COEt CH CH CH 301 c-Pr H CH CH CH CH CH 302 c-Pr H CCl CH CH CH CH 303 c-Pr H CH CCl CH CH CH 304 c-Pr H CH CH CCl CH CH 305 c-Pr H CCl CH CCl CH CH 306 c-Pr H CCl CH CH CCl CH 307 c-Pr H CF CH CH CH CH 308 c-Pr H CH CF CH CH CH 309 c-Pr H CH CH CF CH CH 310 c-Pr H CF CH CF CH CH 311 c-Pr H CH CF CH CF CH 312 c-Pr H CF CH CH CH CF 313 c-Pr H CBr CH CH CH CH 314 c-Pr H CH CBr CH CH CH 315 c-Pr H CH CH CBr CH CH 316 c-Pr H CI CH CH CH CH 317 c-Pr H COCH.sub.3 CH CH CH CH 318 c-Pr H CCF.sub.3 CH CH CH CH 319 c-Pr H CCH.sub.3 CH CH CH CH 320 c-Pr H CCN CH CH CH CH 321 c-Pr H CH CH CI CH CH 322 c-Pr H CH CH COCH.sub.3 CH CH 323 c-Pr H CH CH CCF.sub.3 CH CH 324 c-Pr H CH CH CCH.sub.3 CH CH 325 c-Pr H CH CH CCN CH CH 326 c-Pr H CH CH CSCF.sub.3 CH CH 327 c-Pr H CH CH COCF.sub.3 CH CH 328 c-Pr H CH CH COEt CH CH 329 c-Pr H CH CH Ct-Bu CH CH 330 c-Pr H CF CH CBr CH CH 331 c-Pr H N CH CH CH CH 332 c-Pr H N CCl CH CH CH 333 c-Pr H N CH CCl CH CH 334 c-Pr H N CH CH CH CCl 335 c-Pr H CH N CH CH CH 336 c-Pr H CH N CCl CH CH 337 c-Pr H CH CH N CH CH 338 c-Pr H N CH CH CH N 339 c-Pr H N CH CH N CH 340 c-Pr H CCl CH N CH CH 341 c-Pr H CH CI CH CH CH 342 c-Pr H CH COCH.sub.3 CH CH CH 343 c-Pr H CH CCF.sub.3 CH CH CH 344 c-Pr H CH CCH.sub.3 CH CH CH 345 c-Pr H CH CCN CH CH CH 346 c-Pr H CH CCH.sub.3 CH CH CH 347 c-Pr H CH CCl CH CCl CH 348 c-Pr H CH CSCF.sub.3 CH CH CH 349 c-Pr H CH COCF.sub.3 CH CH CH 350 c-Pr H CH COEt CH CH CH 351 CH.sub.3 H CH.sub.2 CH CH CH CH CH 352 CH.sub.3 H CH.sub.2 CCl CH CH CH CH 353 CH.sub.3 H CH.sub.2 CH CCl CH CH CH 354 CH.sub.3 H CH.sub.2 CH CH CCl CH CH 355 CH.sub.3 H CH.sub.2 CCl CH CCl CH CH 356 CH.sub.3 H CH.sub.2 CCl CH CH CCl CH 357 CH.sub.3 H CH.sub.2 CF CH CH CH CH 358 CH.sub.3 H CH.sub.2 CH CF CH CH CH 359 CH.sub.3 H CH.sub.2 CH CH CF CH CH 360 CH.sub.3 H CH.sub.2 CF CH CF CH CH 361 CH.sub.3 H CH.sub.2 CH CF CH CF CH 362 CH.sub.3 H CH.sub.2 CF CH CH CH CF 363 CH.sub.3 H CH.sub.2 CBr CH CH CH CH 364 CH.sub.3 H CH.sub.2 CH CBr CH CH CH 365 CH.sub.3 H CH.sub.2 CH CH CBr CH CH 366 CH.sub.3 H CH.sub.2 CI CH CH CH CH 367 CH.sub.3 H CH.sub.2 COCH.sub.3 CH CH CH CH 368 CH.sub.3 H CH.sub.2 CCF.sub.3 CH CH CH CH 369 CH.sub.3 H CH.sub.2 CCH.sub.3 CH CH CH CH 370 CH.sub.3 H CH.sub.2 CCN CH CH CH CH 371 CH.sub.3 H CH.sub.2 CH CH CI CH CH 372 CH.sub.3 H CH.sub.2 CH CH COCH.sub.3 CH CH 373 CH.sub.3 H CH.sub.2 CH CH CCF.sub.3 CH CH 374 CH.sub.3 H CH.sub.2 CH CH CCH.sub.3 CH CH 375 CH.sub.3 H CH.sub.2 CH CH CCN CH CH 376 CH.sub.3 H CH.sub.2 CH CH CSCF.sub.3 CH CH 377 CH.sub.3 H CH.sub.2 CH CH COCF.sub.3 CH CH 378 CH.sub.3 H CH.sub.2 CH CH COEt CH CH 379 CH.sub.3 H CH.sub.2 CH CH Ct-Bu CH CH 380 CH.sub.3 H CH.sub.2 CF CH CBr CH CH 381 CH.sub.3 H CH.sub.2 N CH CH CH CH 382 CH.sub.3 H CH.sub.2 N CCl CH CH CH 383 CH.sub.3 H CH.sub.2 N CH CCl CH CH 384 CH.sub.3 H CH.sub.2 N CH CH CH CCl 385 CH.sub.3 H CH.sub.2 CH N CH CH CH 386 CH.sub.3 H CH.sub.2 CH N CCl CH CH 387 CH.sub.3 H CH.sub.2 CH CH N CH CH 388 CH.sub.3 H CH.sub.2 N CH CH CH N 389 CH.sub.3 H CH.sub.2 N CH CH N CH 390 CH.sub.3 H CH.sub.2 CCl CH N CH CH 391 CH.sub.3 H CH.sub.2 CH CI CH CH CH 392 CH.sub.3 H CH.sub.2 CH COCH.sub.3 CH CH CH 393 CH.sub.3 H CH.sub.2 CH CCF.sub.3 CH CH CH 394 CH.sub.3 H CH.sub.2 CH CCN CH CH CH 395 CH.sub.3 H CH.sub.2 CCH.sub.3 CH CH CH CCH.sub.3 396 CH.sub.3 H CH.sub.2 CCl CH CH CH CCl 397 CH.sub.3 H CH.sub.2 CH CCl CH CCl CH 398 CH.sub.3 H CH.sub.2 CH CSCF.sub.3 CH CH CH 399 CH.sub.3 H CH.sub.2 CH COCF.sub.3 CH CH CH 400 CH.sub.3 H CH.sub.2 CH COEt CH CH CH 401 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CH CH CH 402 CH.sub.3 H CH.sub.2CH.sub.2 CCl CH CH CH CH 403 CH.sub.3 H CH.sub.2CH.sub.2 CH CCl CH CH CH 404 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CCl CH CH 405 CH.sub.3 H CH.sub.2CH.sub.2 CCl CH CCl CH CH 406 CH.sub.3 H CH.sub.2CH.sub.2 CCl CH CH CCl CH 407 CH.sub.3 H CH.sub.2CH.sub.2 CF CH CH CH CH 408 CH.sub.3 H CH.sub.2CH.sub.2 CH CF CH CH CH 409 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CF CH CH 410 CH.sub.3 H CH.sub.2CH.sub.2 CF CH CF CH CH 411 CH.sub.3 H CH.sub.2CH.sub.2 CH CF CH CF CH 412 CH.sub.3 H CH.sub.2CH.sub.2 CF CH CH CH CF 413 CH.sub.3 H CH.sub.2CH.sub.2 CBr CH CH CH CH 414 CH.sub.3 H CH.sub.2CH.sub.2 CH CBr CH CH CH 415 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CBr CH CH 416 CH.sub.3 H CH.sub.2CH.sub.2 CI CH CH CH CH 417 CH.sub.3 H CH.sub.2CH.sub.2 COCH.sub.3 CH CH CH CH 418 CH.sub.3 H CH.sub.2CH.sub.2 CCF.sub.3 CH CH CH CH 419 CH.sub.3 H CH.sub.2CH.sub.2 CCH.sub.3 CH CH CH CH 420 CH.sub.3 H CH.sub.2CH.sub.2 CCN CH CH CH CH 421 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CI CH CH 422 CH.sub.3 H CH.sub.2CH.sub.2 CH CH COCH.sub.3 CH CH 423 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CCF.sub.3 CH CH 424 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CCH.sub.3 CH CH 425 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CCN CH CH 426 CH.sub.3 H CH.sub.2CH.sub.2 CH CH CSCF.sub.3 CH CH 427 CH.sub.3 H CH.sub.2CH.sub.2 CH CH COCF.sub.3 CH CH 428 CH.sub.3 H CH.sub.2CH.sub.2 CH CH COEt CH CH 429 CH.sub.3 H CH.sub.2CH.sub.2 CH CH Ct-Bu CH CH 430 CH.sub.3 H CH.sub.2CH.sub.2 CF CH CBr CH CH 431 CH.sub.3 H CH.sub.2CH.sub.2 N CH CH CH CH 432 CH.sub.3 H CH.sub.2CH.sub.2 N CCl CH CH CH 433 CH.sub.3 H CH.sub.2CH.sub.2 N CH CCl CH CH 434 CH.sub.3 H CH.sub.2CH.sub.2 N CH CH CH CCl 435 CH.sub.3 H CH.sub.2CH.sub.2 CH N CH CH CH 436 CH.sub.3 H CH.sub.2CH.sub.2 CH N CCl CH CH 437 CH.sub.3 H CH.sub.2CH.sub.2 CH CH N CH CH 438 CH.sub.3 H CH.sub.2CH.sub.2 N CH CH CH N 439 CH.sub.3 H CH.sub.2CH.sub.2 N CH CH N CH 440 CH.sub.3 H CH.sub.2CH.sub.2 CCl CH N CH CH 441 CH.sub.3 H CH.sub.2CH.sub.2 CH CI CH CH CH 442 CH.sub.3 H CH.sub.2CH.sub.2 CH COCH.sub.3 CH CH CH 443 CH.sub.3 H CH.sub.2CH.sub.2 CH CCF.sub.3 CH CH CH 444 CH.sub.3 H CH.sub.2CH.sub.2 CH CCN CH CH CH 445 CH.sub.3 H CH.sub.2CH.sub.2 CCH.sub.3 CH CH CH CCH.sub.3 446 CH.sub.3 H CH.sub.2CH.sub.2 CCl CH CH CH CCl 447 CH.sub.3 H CH.sub.2CH.sub.2 CH CCl CH CCl CH 448 CH.sub.3 H CH.sub.2CH.sub.2 CH CSCF.sub.3 CH CH CH 449 CH.sub.3 H CH.sub.2CH.sub.2 CH COCF.sub.3 CH CH CH 450 CH.sub.3 H CH.sub.2CH.sub.2 CH COEt CH CH CH 451 H H CH.sub.2CH.sub.2 CH CH CH CH CH 452 H H CH.sub.2CH.sub.2 CCl CH CH CH CH 453 H H CH.sub.2CH.sub.2 CH CCl CH CH CH 454 H H CH.sub.2CH.sub.2 CH CH CCl CH CH 455 H H CH.sub.2CH.sub.2 CCl CH CCl CH CH 456 H H CH.sub.2CH.sub.2 CCl CH CH CCl CH 457 H H CH.sub.2CH.sub.2 CF CH CH CH CH 458 H H CH.sub.2CH.sub.2 CH CF CH CH CH 459 H H CH.sub.2CH.sub.2 CH CH CF CH CH 460 H H CH.sub.2CH.sub.2 CF CH CF CH CH 461 H H CH.sub.2CH.sub.2 CH CF CH CF CH 462 H H CH.sub.2CH.sub.2 CF CH CH CH CF 463 H H CH.sub.2CH.sub.2 CBr CH CH CH CH 464 H H CH.sub.2CH.sub.2 CH CBr CH CH CH 465 H H CH.sub.2CH.sub.2 CH CH CBr CH CH 466 H H CH.sub.2CH.sub.2 CI CH CH CH CH 467 H H CH.sub.2CH.sub.2 COCH.sub.3 CH CH CH CH 468 H H CH.sub.2CH.sub.2 CCF.sub.3 CH CH CH CH 469 H H CH.sub.2CH.sub.2 CCH.sub.3 CH CH CH CH 470 H H CH.sub.2CH.sub.2 CCN CH CH CH CH 471 H H CH.sub.2CH.sub.2 CH CH CI CH CH 472 H H CH.sub.2CH.sub.2 CH CH COCH.sub.3 CH CH 473 H H CH.sub.2CH.sub.2 CH CH CCF.sub.3 CH CH 474 H H CH.sub.2CH.sub.2 CH CH CCH.sub.3 CH CH 475 H H CH.sub.2CH.sub.2 CH CH CCN CH CH 476 H H CH.sub.2CH.sub.2 CH CH CSCF.sub.3 CH CH 477 H H CH.sub.2CH.sub.2 CH CH COCF.sub.3 CH CH 478 H H CH.sub.2CH.sub.2 CH CH COEt CH CH 479 H H CH.sub.2CH.sub.2 CH CH Ct-Bu CH CH 480 H H CH.sub.2CH.sub.2 CF CH CBr CH CH 481 H H CH.sub.2CH.sub.2 N CH CH CH CH 482 H H CH.sub.2CH.sub.2 N CCl CH CH CH 483 H H CH.sub.2CH.sub.2 N CH CCl CH CH 484 H H CH.sub.2CH.sub.2 N CH CH CH CCl 485 H H CH.sub.2CH.sub.2 CH N CH CH CH 486 H H CH.sub.2CH.sub.2 CH N CCl CH CH 487 H H CH.sub.2CH.sub.2 CH CH N CH CH 488 H H CH.sub.2CH.sub.2 N CH CH CH N 489 H H CH.sub.2CH.sub.2 N CH CH N CH 490 H H CH.sub.2CH.sub.2 CCl CH N CH CH 491 H H CH.sub.2CH.sub.2 CH CI CH CH CH 492 H H CH.sub.2CH.sub.2 CH COCH.sub.3 CH CH CH 493 H H CH.sub.2CH.sub.2 CH CCF.sub.3 CH CH CH 494 H H CH.sub.2CH.sub.2 CH CCN CH CH CH 495 H H CH.sub.2CH.sub.2 CCH.sub.3 CH CH CH CCH.sub.3 496 H H CH.sub.2CH.sub.2 CCl CH CH CH CCl 497 H H CH.sub.2CH.sub.2 CH CCl CH CCl CH 498 H H CH.sub.2CH.sub.2 CH CSCF.sub.3 CH CH CH 499 H H CH.sub.2CH.sub.2 CH COCF.sub.3 CH CH CH 500 H H CH.sub.2CH.sub.2 CH COEt CH CH CH 501 H H CH CH COH CH CH 502 H H CH COH COCH.sub.3 CCl CH 503 CH.sub.3 CH.sub.3 CH CH CH CH CH 504 H H CH CH CNMe.sub.2 CH CH 505 H H CH CCH.sub.3 COCH.sub.3 CH CH 506 H H CH CCl COCH.sub.3 CH CH 507 H H N CH CCH.sub.3 N CH 508 H H N CH CCl N CH 509 H H CCl CH [00045] CH 510 c-Bu H CH.sub.2CH.sub.3 CH CH CH CH CH 511 c-Pr H CH.sub.2CH.sub.3 CH CH CH CH CH 512 CO.sub.2CH.sub.3 H CH CH CH CH CH 513 CO.sub.2CH.sub.3 H CCl CH CH CH CH 514 CO.sub.2CH.sub.3 H CH CCl CH CH CH 515 CO.sub.2CH.sub.3 H CH CH CCl CH CH 516 CO.sub.2CH.sub.3 H CF CH CH CH CH 517 CO.sub.2CH.sub.3 H CH CF CH CH CH 518 CO.sub.2CH.sub.3 H CH CH CF CH CH 519 CO.sub.2CH.sub.3 H CCl CH CCl CH CCl 520 CO.sub.2CH.sub.3 H CH CH CBr CH CH 521 CO.sub.2CH.sub.3 H CH CH CI CH CH 522 CO.sub.2CH.sub.3 H CH CH COCH.sub.3 CH CH 523 CO.sub.2CH.sub.3 H CH CH CCN CH CH 524 CO.sub.2CH.sub.3 H CH CCl CH CCl CH 525 CO.sub.2Et H CH CH CH CH CH 526 CO.sub.2Et H CCl CH CH CH CH 527 CO.sub.2Et H CH CCl CH CH CH 528 CO.sub.2Et H CH CH CCl CH CH 529 CO.sub.2Et H CF CH CH CH CH 530 CO.sub.2Et H CH CF CH CH CH 531 CO.sub.2Et H CH CH CF CH CH 532 CO.sub.2Et H CCl CH CCl CH CCl 533 CO.sub.2Et H CH CH CBr CH CH 534 CO.sub.2Et H CH CH CI CH CH 535 CO.sub.2Et H CH CH COCH.sub.3 CH CH 536 CO.sub.2Et H CH CH CCN CH CH 537 CO.sub.2Et H CH CCl CH CCl CH 538 CO.sub.2CH.sub.3 H CH.sub.2 CH CH CH CH CH 539 CO.sub.2CH.sub.3 H CH.sub.2 CCl CH CH CH CH 540 CO.sub.2CH.sub.3 H CH.sub.2 CH CCl CH CH CH 541 CO.sub.2CH.sub.3 H CH.sub.2 CH CH CCl CH CH 542 CO.sub.2CH.sub.3 H CH.sub.2 CF CH CH CH CH 543 CO.sub.2CH.sub.3 H CH.sub.2 CH CF CH CH CH 544 CO.sub.2CH.sub.3 H CH.sub.2 CH CH CF CH CH 545 CO.sub.2CH.sub.3 H CH.sub.2 CCl CH CCl CH CCl 546 CO.sub.2CH.sub.3 H CH.sub.2 CH CH CBr CH CH 547 CO.sub.2CH.sub.3 H CH.sub.2 CH CH CI CH CH 548 CO.sub.2CH.sub.3 H CH.sub.2 CH CH COCH.sub.3 CH CH 549 CO.sub.2CH.sub.3 H CH.sub.2 CH CH CCN CH CH 550 CO.sub.2CH.sub.3 H CH.sub.2 CH CCl CH CCl CH 551 CO.sub.2Et H CH.sub.2 CH CH CH CH CH 552 CO.sub.2Et H CH.sub.2 CCl CH CH CH CH 553 CO.sub.2Et H CH.sub.2 CH CCl CH CH CH 554 CO.sub.2Et H CH.sub.2 CH CH CCl CH CH 555 CO.sub.2Et H CH.sub.2 CF CH CH CH CH 556 CO.sub.2Et H CH.sub.2 CH CF CH CH CH 557 CO.sub.2Et H CH.sub.2 CH CH CF CH CH 558 CO.sub.2Et H CH.sub.2 CCl CH CCl CH CCl 559 CO.sub.2Et H CH.sub.2 CH CH CBr CH CH 560 CO.sub.2Et H CH.sub.2 CH CH CI CH CH 561 CO.sub.2Et H CH.sub.2 CH CH COCH.sub.3 CH CH 562 CO.sub.2Et H CH.sub.2 CH CH CCN CH CH 563 CO.sub.2Et H CH.sub.2 CH CCl CH CCl CH 564 CO.sub.2Et H CH.sub.2 N CH CH CH CH 565 CO.sub.2CH.sub.3 H CH.sub.2 N CH CH CH CH 566 CO.sub.2Et H N CH CH CH CH 567 CO.sub.2CH.sub.3 H N CH CH CH CH 568 CO.sub.2Et H CH.sub.2 CH N CH CH CH 569 CO.sub.2CH.sub.3 H CH.sub.2 CH N CH CH CH 570 CO.sub.2Et H CH N CH CH CH 571 CO.sub.2CH.sub.3 H CH N CH CH CH 572 CO.sub.2CH.sub.3 H CH.sub.2 CCl CH CCl CH CH 573 CO.sub.2CH.sub.3 H CCl CH CCl CH CH 574 CO.sub.2Et H CH.sub.2 CCl CH CCl CH CH 575 CO.sub.2Et H CCl CH CCl CH CH 576 [00046] H CH CH CH CH CH 577 [00047] H CH CH CCl CH CH 578 [00048] H CH CH CBr CH CH 579 [00049] H CH CH CI CH CH 580 [00050] H CH CCl CH CH CH 581 [00051] H CCl CH CCl CH CH 582 [00052] H CH.sub.2 CH CH CH CH CH 583 [00053] H CH.sub.2 CH CH CCl CH CH 584 [00054] H CH.sub.2 CH CH CBr CH CH 585 [00055] H CH.sub.2 CH CH CI CH CH 586 [00056] H CH.sub.2 CH CCl CH CH CH 587 [00057] H CH.sub.2 CCl CH CCl CH CH 588 [00058] H CH CH CH CH CH 589 [00059] H CH CH CCl CH CH 590 [00060] H CH CH CBr CH CH 591 [00061] H CH CH CI CH CH 592 [00062] H CH CCl CH CH CH 593 [00063] H CCl CH CCl CH CH 594 [00064] H CH.sub.2 CH CH CH CH CH 595 [00065] H CH.sub.2 CH CH CCl CH CH 596 [00066] H CH.sub.2 CH CH CBr CH CH 597 [00067] H CH.sub.2 CH CH CI CH CH 598 [00068] H CH.sub.2 CH CCl CH CH CH 599 [00069] H CH.sub.2 CCl CH CCl CH CH 600 [00070] H N CH CH CH CH 601 CO.sub.2CH.sub.3 H CH.sub.2 CCl CH CCF.sub.3 CH CH 602 CO.sub.2Et H CH.sub.2 CCl CH CCF.sub.3 CH CH 603 H H CCO.sub.2CH.sub.3 CH CH CH CH 604 H H CH CCO.sub.2CH.sub.3 CH CH CH 605 H H CH CH CCO.sub.2CH.sub.3 CH CH 606 H H CCO.sub.2Et CH CH CH CH 607 H H CH CCO.sub.2Et CH CH CH 608 H H CH CH CCO.sub.2Et CH CH 609 H H CCO.sub.2H CH CH CH CH 610 H H CH CCO.sub.2H CH CH CH 611 H H CH.sub.2 CH CH CH CH CH 612 H H CH.sub.2 CCl CH CH CH CH 613 H H CH.sub.2 CH CCl CH CH CH 614 H H CH.sub.2 CH CH CCl CH CH 615 H H CH.sub.2 CCl CH CCl CH CH 616 H H CH.sub.2 CCl CH CH CCl CH 617 H H CH.sub.2 CF CH CH CH CH 618 H H CH.sub.2 CH CF CH CH CH 619 H H CH.sub.2 CH CH CF CH CH 620 H H CH.sub.2 CF CH CF CH CH 621 H H CH.sub.2 CH CF CH CF CH 622 H H CH.sub.2 CF CH CH CH CF 623 H H CH.sub.2 CBr CH CH CH CH 624 H H CH.sub.2 CH CBr CH CH CH 625 H H CH.sub.2 CH CH CBr CH CH 626 H H CH.sub.2 CI CH CH CH CH 627 H H CH.sub.2 COCH.sub.3 CH CH CH CH 628 H H CH.sub.2 CCF.sub.3 CH CH CH CH 629 H H CH.sub.2 CCH.sub.3 CH CH CH CH 630 H H CH.sub.2 CCN CH CH CH CH 631 H H CH.sub.2 CH CH CI CH CH 632 H H CH.sub.2 CH CH COCH.sub.3 CH CH 633 H H CH.sub.2 CH CH CCF.sub.3 CH CH 634 H H CH.sub.2 CH CH CCH.sub.3 CH CH 635 H H CH.sub.2 CH CH CCN CH CH 636 H H CH.sub.2 CH CH CSCF.sub.3 CH CH 637 H H CH.sub.2 CH CH COCF.sub.3 CH CH 638 H H CH.sub.2 CH CH COEt CH CH 639 H H CH.sub.2 CH CH Ct-Bu CH CH 640 H H CH.sub.2 CF CH CBr CH CH 641 H H CH.sub.2 N CH CH CH CH 642 H H CH.sub.2 N CCl CH CH CH 643 H H CH.sub.2 N CH CCl CH CH 644 H H CH.sub.2 N CH CH CH CCl 645 H H CH.sub.2 CH N CH CH CH 646 H H CH.sub.2 CH N CCl CH CH 647 H H CH.sub.2 CH CH N CH CH 648 H H CH.sub.2 N CH CH CH N 649 H H CH.sub.2 N CH CH N CH 650 H H CH.sub.2 CCl CH N CH CH 651 H H CH.sub.2 CH CI CH CH CH 652 H H CH.sub.2 CH COCH.sub.3 CH CH CH 653 H H CH.sub.2 CH CCF.sub.3 CH CH CH 654 H H CH.sub.2 CH CCN CH CH CH 655 H H CH.sub.2 CCH.sub.3 CH CH CH CCH.sub.3 656 H H CH.sub.2 CCl CH CH CH CCl 657 H H CH.sub.2 CH CCl CH CCl CH 658 H H CH.sub.2 CH CSCF.sub.3 CH CH CH 659 H H CH.sub.2 CH COCF.sub.3 CH CH CH 660 H H CH.sub.2 CH COEt CH CH CH 661 H H CH.sub.2 CH COCH.sub.3 COCH.sub.3 COCH.sub.3 CH 662 H H CH.sub.2 CH COCH.sub.3 COCH.sub.3 CH CH 663 H H CH.sub.2 CH CCH.sub.3 CCH.sub.3 CH CH 664 H H CH.sub.2 CCH.sub.3 CH CCH.sub.3 CH CH 665 H H CH.sub.2 CCH.sub.3 CH CCH.sub.3 CH CCH.sub.3 666 H H CH.sub.2 CEt CH CCH.sub.3 CH CH 667 H H CH.sub.2 CNO.sub.2 CH CH CH CH 668 H H CH.sub.2 CH CNO.sub.2 CH CH CH 669 H H CH.sub.2 CH CH CNO.sub.2 CH CH 670 H H CH.sub.2 [00071] CH CH CH 671 H H CCHF.sub.2 CH CH CH CH 672 H H CH CCHF.sub.2 CH CH CH 673 H H CH CH CCHF.sub.2 CH CH 674 H H CCH.sub.3 CCH.sub.3 CCH.sub.3 CCH.sub.3 CCH.sub.3 675 H H CF CF CF CF CF 676 H H COCHF.sub.2 CH CH CH CH 677 H H CH COCHF.sub.2 CH CH CH 678 H H CH CH COCHF.sub.2 CH CH 679 H H CCN N CH CH CH 680 H H CCl CCl CCF.sub.3 CCl CCl 681 H H CH N CCl CH CCl

[0213] A2. Compounds A2-1 to A2-681 of the general formula (Id1) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A2-1 to A2-681) in table 1 above.

##STR00072##

[0214] A3. Compounds A3-1 to A3-681 of the general formula (If1) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A3-1 to A3-681) in table 1 above.

##STR00073##

[0215] A4. Compounds A4-1 to A4-681 of the general formula (Ii1) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A4-1 to A4-681) in table 1 above.

##STR00074##

[0216] A5. Compounds A5-1 to A5-681 of the general formula (Id2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A5-1 to A5-681) in table 1 above.

##STR00075##

[0217] A6. Compounds A6-1 to A6-681 of the general formula (Id3) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A6-1 to A6-681) in table 1 above.

##STR00076##

[0218] A7. Compounds A7-1 to A7-681 of the general formula (Id4) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A7-1 to A7-681) in table 1 above.

##STR00077##

[0219] A8. Compounds A8-1 to A8-681 of the general formula (Id5) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A8-1 to A8-681) in table 1 above.

##STR00078##

[0220] A9. Compounds A9-1 to A9-681 of the general formula (Id6) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A9-1 to A9-681) in table 1 above.

##STR00079##

[0221] A10. Compounds A10-1 to A10-681 of the general formula (Id7) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A10-1 to A10-681) in table 1 above.

##STR00080##

[0222] A11. Compounds A11-1 to A11-681 of the general formula (Id8) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A11-1 to A11-681) in table 1 above.

##STR00081##

[0223] A12. Compounds A12-1 to A12-681 of the general formula (Io1) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A12-1 to A12-681) in table 1 above.

##STR00082##

[0224] A13. Compounds A13-1 to A13-681 of the general formula (Il1) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A13-1 to A13-681) in table 1 above.

##STR00083##

[0225] A14. Compounds A14-1 to A14-681 of the general formula (Id9) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A14-1 to A14-681) in table 1 above.

##STR00084##

[0226] A15. Compounds A15-1 to A15-681 of the general formula (Id10) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A15-1 to A15-681) in table 1 above.

##STR00085##

[0227] A16. Compounds A16-1 to A16-681 of the general formula (Id11) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A16-1 to A16-681) in table 1 above.

##STR00086##

[0228] A17. Compounds A17-1 to A17-681 of the general formula (Id12) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A17-1 to A17-681) in table 1 above.

##STR00087##

[0229] A18. Compounds A18-1 to A18-681 of the general formula (Id13) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A18-1 to A18-681) in table 1 above.

##STR00088##

[0230] A19. Compounds A19-1 to A19-681 of the general formula (Id14) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds A19-1 to A19-681) in table 1 above.

##STR00089##

[0231] B1. Compounds B1-1 to B1-681 of the general formula (Ic2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B1-1 to B1-681) in table 1 above.

##STR00090##

[0232] B2. Compounds B2-1 to B2-681 of the general formula (Id15) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B2-1 to B2-681) in table 1 above.

##STR00091##

[0233] B3. Compounds B3-1 to B3-681 of the general formula (If2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B3-1 to B3-681) in table 1 above.

##STR00092##

[0234] B4. Compounds B4-1 to B4-681 of the general formula (Ii2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B4-1 to B4-681) in table 1 above.

##STR00093##

[0235] B5. Compounds B5-1 to B5-681 of the general formula (Ij2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B5-1 to B5-681) in table 1 above.

##STR00094##

[0236] B6. Compounds B6-1 to B6-681 of the general formula (Io2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B6-1 to B6-681) in table 1 above.

##STR00095##

[0237] B7. Compounds B7-1 to B7-681 of the general formula (Il2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B7-1 to B7-681) in table 1 above.

##STR00096##

[0238] B8. Compounds B8-1 to B8-681 of the general formula (Id16) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B8-1 to B8-681) in table 1 above.

##STR00097##

[0239] B9. Compounds B9-1 to B9-681 of the general formula (Ik2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B9-1 to B9-681) in table 1 above.

##STR00098##

[0240] B10. Compounds B10-1 to B10-681 of the general formula (In2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B10-1 to B10-681) in table 1 above.

##STR00099##

[0241] B11. Compounds B11-1 to B11-681 of the general formula (Iq1) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B11-1 to B11-681) in table 1 above.

##STR00100##

[0242] B12. Compounds B12-1 to B12-681 of the general formula (Ig2) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds B12-1 to B12-681) in table 1 above.

##STR00101##

[0243] C1. Compounds C1-1 to C1-681 of the general formula (Ic3) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C1-1 to C1-681) in table 1 above.

##STR00102##

[0244] C2. Compounds C2-1 to C2-681 of the general formula (Id17) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C2-1 to C2-681) in table 1 above.

##STR00103##

[0245] C3. Compounds C3-1 to C3-681 of the general formula (If3) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C3-1 to C3-681) in table 1 above.

##STR00104##

[0246] C.sub.4. Compounds C4-1 to C4-681 of the general formula (Ii3) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C4-1 to C4-681) in table 1 above.

##STR00105##

[0247] C5. Compounds C5-1 to C5-681 of the general formula (Id18) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C5-1 to C5-681) in table 1 above.

##STR00106##

[0248] C6. Compounds C6-1 to C6-681 of the general formula (Ii3) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C6-1 to C6-681) in table 1 above.

##STR00107##

[0249] C7. Compounds C7-1 to C7-681 of the general formula (Ij3) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C7-1 to C7-681) in table 1 above.

##STR00108##

[0250] C8. Compounds C8-1 to C8-681 of the general formula (Il3) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds C8-1 to C8-681) in table 1 above.

##STR00109##

[0251] D1. Compounds D1-1 to D1-681 of the general formula (Id19) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds D1-1 to D1-681) in table 1 above.

##STR00110##

[0252] D2. Compounds D2-1 to D2-681 of the general formula (Id20) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds D2-1 to D2-681) in table 1 above.

##STR00111##

[0253] E1. Compounds E1-1 to E1-681 of the general formula (Id21) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds E1-1 to E1-681) in table 1 above.

##STR00112##

[0254] F1. Compounds F1-1 to F1-681 of the general formula (Id22) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds F1-1 to F1-681) in table 1 above.

##STR00113##

[0255] F2. Compounds F2-1 to F2-681 of the general formula (Id23) in which R.sup.5, R.sup.6, Y, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 correspond to the definitions (Nos. 1 to 681; corresponding to compounds F2-1 to F2-681) in table 1 above.

##STR00114##

Spectroscopic Data of Selected Table Examples

[0256] The spectroscopic data listed hereinafter for selected table examples were evaluated via conventional .sup.1H NMR interpretation or via

[0257] NMR peak list methods.

[0258] a) Conventional .sup.1H NMR Interpretation

Example No. A5-5

[0259] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.18 (m, 1H), 7.93-7.88 (m, 1H), 7.52 (m, 1H), 7.46-7.34 (m, 3H), 5.51 (s, 2H), 4.33-4.28 (m, 2H), 3.71-3.64 (m, 2H).

Example No. A5-6

[0260] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.18 (m, 1H), 7.92 (m, 1H), 7.46-7.37 (m, 4H), 5.51 (s, 2H), 4.35-4.29 (m, 2H), 3.70-3.62 (m, 2H).

Example No. A5-36

[0261] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 10.06 (s, 1H), 8.69 (s, 1H), 8.53 (s, 1H), 8.18 (s, 1H), 8.03 (m, 1H), 7.92 (m, 1H), 7.46 (m, 1H), 5.79 (s, 2H), 4.36-4.30 (m, 2H), 3.73-3.66 (m, 2H).

Example No. A5-37

[0262] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 10.60 (s, 1H), 8.59 (s, 1H), 8.22 (s, 1H), 8.19 (m, 1H), 7.92 (m, 1H), 7.46 (m, 1H), 5.54 (s, 2H), 4.32-4.26 (m, 2H), 3.70-3.61 (m, 2H.

Example No. A12-1

[0263] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.72-7.65 (m, 3H), 7.53-7.47 (m, 2H), 7.43-7.33 (m, 3H), 5.37 (s, 2H), 4.52-4.38 (m, 2H), 3.38-3.28 (m, 2H), 3.08-2.95 (m, 2H), 2.75-2.67 (m, 2H), 2.35 (s, 3H).

Example No. A12-40

[0264] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.50 (m, 1H), 7.65-7.58 (m, 2H), 7.53-7.48 (m, 2H), 7.42-7.37 (m, 1H), 5.59 (s, 2H), 4.58-4.54 (m, 2H), 3.55-3.45 (m, 2H), 3.11-3.01 (m, 2H), 2.72-2.66 (m, 2H), 2.34 (s, 3H).

Example No. A12-61

[0265] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.92 (d, 1H), 7.78 (d, 1H), 7.73-7.67 (m, 2H), 7.62-7.56 (m, 2H), 7.53-7.48 (m, 1H), 7.45-7.40 (m, 1H), 5.40 (s, 2H), 4.45-4.35 (br. m, 2H), 3.43-3.35 (m, 2H), 3.02-2.94 (m, 2H), 2.73-2.69 (m, 2H), 2.35 (s, 3H).

Example No. A13-1

[0266] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.72 (m, 1H), 7.68-7.61 (m, 2H), 7.53-7.47 (m, 2H), 7.43-7.34 (m, 3H), 5.38 (s, 2H), 4.75-4.68 (m, 1H), 4.52-4.43 (m, 1H), 3.98-3.92 (m, 1H), 3.38 (s, 3H), 2.92-2.84 (m, 1H), 2.66-2.61 (m, 1H), 2.38-2.27 (m, 1H), 2.23-2.18 (m, 1H), 1.81-1.74 (m, 1H), 1.20-1.12 (m, 1H).

Example No. A13-21

[0267] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.67 (m, 1H), 7.77-7.70 (m, 2H), 7.64 (m, 1H), 7.43-7.39 (m, 1H), 7.38-7.33 (m, 3H), 5.36 (m, 1H), 5.21 (m, 1H), 4.77-4.70 (m, 1H), 4.42-4.35 (m, 1H), 3.96-3.89 (m, 1H), 3.40 (s, 3H), 3.17-3.10 (m, 1H), 2.97-2.89 (m, 1H), 2.33-2.23 (m, 1H), 2.21-2.15 (m, 1H), 1.87-1.79 (m, 1H), 1.33-1.24 (m, 1H).

Example No. A13-40

[0268] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.49 (m, 1H), 7.65-7-59 (m, 2H), 7.52-7.49 (m, 2H), 7.40 (m, 1H), 5.66 (m, 1H), 5.58 (m, 1H), 4.77-4.71 (m, 1H), 4.62-4.57 (m, 1H), 4.04-3.98 (m, 1H), 3.40 (s, 3H), 3.22-3.17 (m, 1H), 2.91-2.86 (m, 1H), 2.42-2.32 (m, 1H), 2.23-2.17 (m, 1H), 1.83-1.77 (m, 1H), 1.18-1.13 (m, 1H).

Example No. A13-61

[0269] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 7.92 (m, 1H), 7.78 (m, 1H), 7.70-7.66 (m, 2H), 7.60-7.56 (m, 2H), 7.51-7.39 (m, 2H), 5.50 (m, 1H), 5.38 (m, 1H), 4.77-4.70 (m, 1H), 4.38-4.28 (m, 1H), 3.97-3.90 (m, 1H), 3.38 (s, 3H), 3.03-2.95 (m, 1H), 2.77-2.71 (m, 1H), 2.38-2.27 (m, 1H), 2.24-2.18 (m, 1H), 1.87-1.79 (m, 1H), 1.33-1.24 (m, 1H).

Example No. B5-11

[0270] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.87 (m, 1H), 8.70 (m, 1H), 7.66-7.61 (m, 1H), 7.54-7.47 (m, 2H), 7.29 (m, 1H), 7.18 (m, 1H), 5.24 (s, 2H), 4.34-4.27 (m, 4H), 3.85-3.80 (m, 2H), 3.32-3.26 (m, 2H).

Example No. B5-21

[0271] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.67 (m, 2H), 8.56 (m, 1H), 7.82-7.77 (m, 1H), 7.70 (m, 1H), 7.52 (m, 1H), 7.39 (m, 1H), 5.23 (s, 2H), 4.50-4.46 (m, 2H), 4.32-4.26 (m, 2H), 3.85-3.81 (m, 2H), 3.50-3.44 (m, 2H).

Example No. B6-1

[0272] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.96 (m, 1H), 8.72 (m, 1H), 7.68 (m, 1H), 7.55-7.47 (m, 2H), 7.42-7.35 (m, 2H), 5.35 (s, 2H), 4.43-4.36 (m, 2H), 3.39-3.29 (m, 2H), 2.97-2.91 (m, 2H), 2.72-2.67 (m, 2H), 2.34 (s, 3H).

Example No. B6-21

[0273] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.67 (m, 2H), 8.61 (m, 1H), 7.79 (m, 1H), 7.70 (m, 1H), 7.52 (m, 1H), 7.38 (m, 1H), 5.20 (s, 2H), 4.55-4.46 (m, 2H), 3.57-3.43 (m, 2H), 2.96-2.90 (m, 2H), 2.74-2.70 (m, 2H), 2.35 (s, 3H).

Example No. B6-40

[0274] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.92 (s, 1H), 8.77 (m, 1H), 8.51 (m, 1H), 7.61 (m, 1H), 7.54 (m, 1H), 5.60 (s, 2H), 4.74-4.69 (m, 2H), 4.29-4.21 (m, 2H), 3.77-3.69 (m, 2H), 3.49-3.44 (m, 2H), 2.83 (s, 3H).

Example No. B6-61

[0275] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.90 (m, 1H), 8.72 (m, 1H), 7.88 (m, 1H), 7.79 (m, 1H), 7.73-7.68 (m, 1H), 7.62-7.56 (m, 2H), 5.38 (s, 2H), 4.43-4.31 (m, 2H), 3.47-3.36 (m, 2H), 3.00-2.88 (m, 2H), 2.78-2.72 (m, 2H), 2.34 (s, 3H).

Example No. B7-1

[0276] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.92 (s, 1H), 8.72 (m, 1H), 7.69 (m, 1H), 7.54-7.48 (m, 2H), 7.43-7.36 (m, 2H), 5.36 (s, 2H), 4.68-4.62 (m, 1H), 4.51-4.43 (m, 1H), 3.97-3.88 (m, 1H), 3.38 (s, 3H), 2.96-2.88 (m, 1H), 2.69-2.64 (m, 1H), 2.35-2.18 (m, 2H), 1.84-1.77 (m, 1H), 1.30-1.15 (m, 1H).

Example No. B7-21

[0277] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.68 (m, 2H), 8.61 (s, 1H), 7.78-7.75 (m, 1H), 7.68 (m, 1H), 7.50 (m, 1H), 7.38 (m, 1H), 5.32 (m, 1H), 5.19 (m, 1H), 4.73-4.68 (m, 1H), 4.46-4.40 (m, 1H), 3.92-3.86 (m, 1H), 3.40 (s, 3H), 3.19-3.12 (m, 1H), 2.98-2.92 (m, 1H), 2.30-2.15 (m, 2H), 1.91-1.84 (m, 1H), 1.40-1.25 (m, 1H).

Example No. B7-61

[0278] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 8.85 (s, 1H), 8.72 (m, 1H), 7.86 (m, 1H), 7.77 (m, 1H), 7.71 (m, 1H), 7.59 (m, 1H), 7.54 (m, 1H), 5.44 (m, 1H), 5.34 (m, 1H), 4.70-4.64 (m, 1H), 4.35-4.29 (m, 1H), 3.92-3.85 (m, 1H), 3.38 (s, 3H), 3.07-3.00 (m, 1H), 2.79-2.75 (m, 1H), 2.26-2.19 (m, 2H), 1.88-1.83 (m, 1H), 1.32-1.23 (m, 1H).

Example No. E1-21

[0279] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 9.22 (s, 1H), 8.71 (s, 1H), 8.66 (m, 1H), 7.82-7.77 (m, 1H), 7.66 (m, 1H), 7.38-7.34 (m, 1H), 5.23 (s, 2H), 4.33-4.28 (m, 2H), 3.71-3.64 (m, 2H), 2.33-2.28 (m, 2H), 2.14-2.09 (m, 2H).

Example No. E1-35

[0280] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 9.24 (s, 1H), 8.99 (s, 1H), 8.57 (m, 1H), 7.85 (m, 1H), 5.47 (s, 2H), 4.43-4.38 (m, 2H), 3.65-3.57 (m, 2H), 2.35-2.29 (m, 2H), 2.06-2.01 (m, 2H).

Example No. E1-61

[0281] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 9.28 (s, 1H), 8.97 (s, 1H), 7.90 (m, 1H), 7.79 (m, 1H), 7.75-7.70 (m, 1H), 7.63-7.58 (m, 1H), 5.39 (s, 2H), 4.31-4.23 (m, 2H), 3.54-3.45 (m, 2H), 2.39-2.30 (m, 2H), 2.21-2.14 (m, 2H).

Example No. F1-61

[0282] .sup.1H-NMR (400 MHz, CDCl.sub.3 , ppm) 9.60 (s, 1H), 9.23 (s, 1H), 7.97 (m, 1H), 7.75 (m, 1H), 7.59-7.50 (m, 3H), 5.38 (s, 2H), 4.28-4.22 (m, 2H), 3.58-3.50 (m, 2H), 2.35-2.27 (m, 2H), 2.22-2.15 (m, 2H).

[0283] b) NMR Peak List Method:

[0284] The .sup.1H NMR data of selected examples are stated in the form of .sup.1H NMR peak lists. For each signal peak, first the value in ppm and then the signal intensity in round brackets are listed. The pairs of value-signal intensity numbers for different signal peaks are listed with separation from one another by semicolons. The peak list for a corresponding example therefore takes the form of: .sub.1 (intensity.sub.1); .sub.2 (intensity.sub.2); . . . ; .sub.i (intensity.sub.i); . . . ; .sub.n (intensity.sub.n)

[0285] The intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities.

[0286] In the case of broad signals, several peaks or the middle of the signal and the relative intensity thereof may be shown in comparison to the most intense signal in the spectrum. To calibrate the chemical shift of .sup.1H-NMR spectra, we used tetramethylsilane and/or the chemical shift of the solvent, particularly in the case of spectra measured in DMSO. Therefore, the tetramethylsilane peak may but need not occur in NMR peak lists. The lists of the .sup.1H NMR peaks are similar to the conventional .sup.1H NMR printouts and thus usually contain all peaks listed in a conventional NMR interpretation. In addition, like conventional .sup.1H NMR printouts, they may show solvent signals, signals of stereoisomers of the target compounds which are likewise provided by the invention, and/or peaks of impurities. In the reporting of compound signals within the delta range of solvents and/or water, our lists of .sup.1H NMR peaks show the standard solvent peaks, for example peaks of DMSO in DMSO-d.sub.6 and the peak of water, which usually have a high intensity on average. The peaks of stereoisomers of the target compounds and/or peaks of impurities usually have a lower intensity on average than the peaks of the target compounds (for example with a purity of >90%). Such stereoisomers and/or impurities may be typical of the particular preparation process. Their peaks can thus help in identifying reproduction of our preparation process with reference to by-product fingerprints.

[0287] An expert calculating the peaks of the target compounds by known methods (MestreC, ACD simulation, but also with empirically evaluated expected values) can, if required, isolate the peaks of the target compounds, optionally using additional intensity filters. This isolation would be similar to the peak picking in question in conventional .sup.1H NMR interpretation.

Example No. A1-37

[0288] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.298 (2.1); 8.198 (1.4); 7.634 (0.8); 7.615 (1.0); 7.526 (0.6); 7.507 (1.1); 7.472 (0.5); 7.454 (0.9); 7.389 (0.5); 7.370 (0.8); 7.262 (28.2); 5.241 (0.8); 5.224 (0.9); 5.215 (0.5); 5.208 (1.0); 5.191 (0.9); 4.892 (5.1); 4.680 (4.5); 4.431 (1.0); 4.415 (1.0); 4.399 (1.0); 4.383 (1.0); 3.804 (16.0); 3.760 (0.9); 3.748 (11.5); 3.690 (0.7); 3.674 (1.0); 3.658 (0.6); 3.462 (0.7); 3.226 (15.3); 2.498 (9.2); 2.312 (7.9); 2.273 (6.6); 2.239 (5.4); 2.228 (0.7); 2.053 (0.7); 1.667 (0.9); 1.265 (0.7); 0.882 (1.2); 0.000 (9.9)

Example No. A2-2

[0289] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.618 (3.4); 7.617 (3.1); 7.600 (3.6); 7.598 (3.9); 7.580 (3.6); 7.575 (6.8); 7.571 (3.9); 7.532 (1.8); 7.516 (4.1); 7.515 (4.0); 7.498 (2.4); 7.496 (2.4); 7.479 (3.5); 7.460 (1.5); 7.435 (2.5); 7.429 (4.3); 7.424 (3.0); 7.414 (6.6); 7.411 (8.3); 7.410 (6.6); 7.407 (6.6); 7.382 (1.7); 7.380 (2.2); 7.378 (2.2); 7.374 (6.9); 7.373 (6.8); 7.362 (3.0); 7.359 (5.2); 7.352 (2.7); 7.342 (1.3); 7.340 (1.3); 7.338 (1.1); 7.336 (2.4); 7.272 (0.7); 7.270 (0.9); 7.269 (1.4); 7.267 (1.8); 7.266 (2.1); 7.265 (2.5); 7.260 (145.2); 7.257 (1.9); 7.256 (1.2); 7.2554 (0.8); 7.2546 (0.5); 7.210 (1.1); 6.996 (0.8); 5.152 (16.0); 4.286 (1.4); 4.266 (2.1); 4.241 (1.5); 3.329 (1.0); 3.323 (1.1); 3.307 (2.7); 3.301 (1.9); 3.292 (2.0); 3.285 (2.0); 3.279 (2.5); 3.264 (1.1); 3.257 (1.1); 2.954 (2.3); 2.884 (2.1); 2.882 (2.1); 2.380 (0.9); 2.373 (1.3); 2.366 (1.4); 2.359 (2.4); 2.345 (2.1); 2.341 (2.7); 2.327 (1.4); 2.318 (1.0); 2.051 (0.8); 2.043 (0.7); 2.033 (2.0); 2.024 (1.8); 2.017 (3.7); 2.013 (3.2); 2.006 (1.9); 1.998 (1.8); 1.978 (0.5); 1.591 (1.3); 1.255 (0.8); 0.008 (2.0); 0.0064 (0.7); 0.0055 (0.8); 0.005 (1.0); 0.004 (1.2); 0.002 (2.8); 0.000 (60.7); 0.003 (2.3); 0.004 (0.8); 0.005 (0.5); 0.009 (1.6)

Example No. A2-4

[0290] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.760 (4.3); 7.756 (4.6); 7.740 (4.9); 7.736 (4.9); 7.646 (3.1); 7.626 (3.6); 7.569 (5.4); 7.565 (4.7); 7.549 (69); 7.545 (52); 7.519 (26); 7.508 (18); 7.490 (30); 7.471 (14); 7.403 (17); 7.385 (25); 7.366 (11); 7.327 (5.0); 7.308 (7.8); 7.288 (4.1); 7.260 (439.2); 7.256 (3.6); 7.254 (1.5); 7.253 (1.1); 7.2524 (0.8); 7.2516 (0.7); 7.251 (0.6); 7.250 (0.6); 7.249 (0.6); 7.210 (2.3); 6.996 (2.2); 5.456 (16.0); 4.306 (2.1); 4.148 (0.9); 4.131 (2.7); 4.113 (2.8); 4.095 (0.9); 3.389 (1.1); 3.372 (2.4); 3.357 (1.9); 3.344 (2.2); 3.328 (1.2); 2.351 (2.3); 2.335 (2.5); 2.176 (0.6); 2.170 (1.8); 2.128 (0.6); 2.063 (2.6); 2.044 (14.4); 2.026 (3.2); 2.009 (1.7); 1.918 (0.6); 1.551 (5.7); 1.277 (4.0); 1.259 (8.6); 1.256 (2.5); 1.241 (3.9); 0.008 (5.3); 0.000 (193.5); 0.009 (5.2); 0.050 (0.9); 0.150 (0.5)

Example No. A2-5

[0291] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.775 (3.8); 7.754 (4.2); 7.646 (1.6); 7.626 (1.9); 7.558 (1.0); 7.541 (1.9); 7.540 (2.0); 7.519 (1.0); 7.514 (1.1); 7.513 (1.1); 7.496 (1.8); 7.485 (4.2); 7.479 (4.7); 7.405 (1.0); 7.401 (0.8); 7.385 (1.5); 7.362 (3.0); 7.357 (2.6); 7.341 (2.5); 7.336 (2.4); 7.274 (0.6); 7.273 (0.6); 7.272 (0.7); 7.2713 (0.7); 7.2705 (0.8); 7.270 (1.0); 7.269 (1.1); 7.268 (1.2); 7.2673 (1.4); 7.2665 (1.6); 7.266 (1.9); 7.265 (2.4); 7.264 (3.1); 7.263 (4.2); 7.260 (143.7); 7.257 (2.4); 7.256 (1.6); 7.255 (1.2); 7.2543 (0.9); 7.2535 (0.7); 7.253 (0.5); 7.210 (1.1); 6.996 (0.8); 5.359 (10.5); 4.293 (0.8); 4.268 (1.1); 4.244 (0.9); 3.394 (0.6); 3.388 (0.5); 3.372 (1.3); 3.366 (0.9); 3.356 (1.0); 3.350 (1.0); 3.344 (1.3); 3.328 (0.6); 3.321 (0.6); 2.362 (0.7); 2.348 (1.2); 2.334 (1.0); 2.330 (1.3); 2.317 (0.7); 2.047 (1.0); 2.044 (1.3); 2.031 (1.6); 2.027 (1.6); 2.020 (1.0); 2.012 (0.9); 1.556 (16.0); 0.008 (2.0); 0.007 (0.6); 0.006 (0.7); 0.005 (0.8); 0.004 (1.1); 0.000 (65.4); 0.005 (0.8); 0.006 (0.7); 0.007 (0.6); 0.009 (1.8)

Example No. A2-6

[0292] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.858 (6.0); 7.852 (6.1); 7.681 (0.6); 7.668 (2.5); 7.649 (3.2); 7.638 (2.9); 7.618 (3.3); 7.577 (0.8); 7.570 (0.8); 7.557 (0.6); 7.538 (1.9); 7.519 (4.0); 7.502 (1.6); 7.403 (1.9); 7.398 (3.7); 7.384 (2.8); 7.376 (9.9); 7.364 (1.4); 7.358 (6.9); 7.352 (6.4); 7.336 (2.2); 7.330 (2.3); 7.271 (1.0); 7.268 (1.6); 7.260 (183.0); 7.254 (0.6); 7.210 (1.2); 6.996 (1.0); 5.356 (16.0); 4.278 (1.3); 4.255 (1.8); 4.233 (1.3); 4.130 (0.9); 4.113 (0.9); 3.452 (1.0); 3.446 (1.0); 3.430 (2.3); 3.424 (1.7); 3.415 (1.8); 3.408 (1.8); 3.402 (2.3); 3.386 (1.0); 3.380 (1.0); 3.030 (0.5); 3.013 (1.3); 2.995 (0.5); 2.385 (0.8); 2.378 (1.1); 2.370 (1.2); 2.364 (2.0); 2.349 (1.9); 2.345 (2.3); 2.332 (1.2); 2.096 (0.7); 2.078 (1.8); 2.061 (2.9); 2.058 (2.7); 2.051 (1.8); 2.043 (5.7); 1.933 (0.6); 1.925 (0.8); 1.915 (1.7); 1.906 (0.7); 1.898 (0.6); 1.655 (0.7); 1.565 (4.8); 1.276 (1.3); 1.259 (2.7); 1.256 (0.9); 1.241 (1.2); 0.008 (2.4); 0.000 (80.4); 0.009 (2.2)

Example No. A2-7

[0293] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.700 (0.7); 7.681 (0.9); 7.631 (3.4); 7.612 (4.0); 7.596 (3.0); 7.577 (5.1); 7.558 (1.0); 7.541 (0.7); 7.519 (2.9); 7.498 (3.8); 7.476 (9.7); 7.474 (9.1); 7.455 (16.0); 7.392 (1.9); 7.369 (8.8); 7.351 (6.2); 7.347 (4.8); 7.329 (3.6); 7.260 (257.5); 7.211 (1.5); 6.996 (1.4); 5.752 (14.3); 4.654 (1.7); 4.628 (2.3); 4.608 (1.8); 4.148 (0.6); 4.131 (1.6); 4.113 (1.6); 3.065 (1.0); 3.046 (2.3); 3.038 (2.1); 3.024 (3.0); 3.013 (2.7); 2.757 (0.5); 2.379 (0.7); 2.366 (0.9); 2.357 (1.2); 2.340 (2.3); 2.327 (2.4); 2.320 (1.9); 2.308 (1.3); 2.044 (7.8); 2.005 (0.7); 1.934 (1.1); 1.926 (1.7); 1.916 (3.1); 1.908 (1.7); 1.895 (2.0); 1.875 (3.5); 1.856 (1.6); 1.656 (1.0); 1.567 (13.2); 1.277 (2.3); 1.259 (4.7); 1.241 (2.2); 0.008 (3.0); 0.000 (114.9); 0.009 (3.2); 0.050 (0.7)

Example No. A2-10

[0294] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.632 (1.4); 7.612 (1.7); 7.581 (1.2); 7.563 (1.5); 7.520 (0.9); 7.516 (1.0); 7.494 (16.0); 7.479 (0.7); 7.396 (0.8); 7.376 (1.2); 7.357 (0.5); 7.261 (74.8); 7.211 (0.5); 5.714 (5.8); 4.607 (0.9); 3.030 (0.7); 3.024 (0.7); 3.012 (1.3); 3.006 (1.4); 2.998 (1.1); 2.990 (0.8); 2.983 (1.0); 2.363 (0.5); 2.345 (1.0); 2.333 (1.0); 2.326 (0.8); 2.315 (0.6); 2.044 (1.4); 1.933 (0.6); 1.925 (0.7); 1.916 (1.4); 1.907 (1.3); 1.899 (1.0); 1.888 (1.5); 1.874 (0.7); 1.869 (0.7); 1.577 (3.8); 1.259 (1.1); 1.255 (1.2); 0.008 (1.1); 0.000 (33.1); 0.009 (0.9)

Example No. A2-11

[0295] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.019 (1.6); 7.737 (0.9); 7.732 (0.9); 7.718 (1.8); 7.713 (1.8); 7.699 (0.9); 7.695 (0.9); 7.624 (1.7); 7.605 (2.0); 7.528 (1.0); 7.519 (0.9); 7.509 (1.9); 7.483 (1.1); 7.465 (1.7); 7.458 (0.7); 7.453 (0.6); 7.445 (1.2); 7.440 (1.1); 7.419 (1.1); 7.414 (0.7); 7.405 (0.7); 7.401 (0.6); 7.377 (0.9); 7.359 (1.4); 7.339 (0.6); 7.260 (117.0); 7.242 (2.4); 7.239 (2.5); 7.223 (1.1); 7.220 (1.1); 7.211 (0.9); 7.155 (1.1); 7.130 (1.5); 7.109 (1.0); 6.996 (0.6); 5.278 (6.5); 4.270 (1.1); 3.379 (0.5); 3.363 (1.2); 3.349 (1.0); 3.336 (1.1); 3.314 (0.5); 2.955 (16.0); 2.884 (14.0); 2.883 (14.2); 2.360 (0.7); 2.345 (1.3); 2.327 (1.3); 2.314 (0.7); 2.044 (1.3); 2.037 (1.3); 2.021 (1.8); 2.011 (1.1); 2.003 (1.0); 1.576 (3.0); 1.259 (0.5); 1.256 (0.6); 0.008 (1.5); 0.000 (50.8); 0.009 (1.5)

Example No. A2-15

[0296] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.762 (2.3); 7.746 (2.5); 7.740 (4.6); 7.724 (4.6); 7.719 (2.6); 7.703 (2.3); 7.628 (5.0); 7.608 (5.8); 7.520 (0.6); 7.486 (0.9); 7.477 (13.9); 7.475 (16.0); 7.467 (8.5); 7.465 (10.0); 7.462 (6.5); 7.445 (0.7); 7.443 (0.7); 7.387 (2.1); 7.385 (2.2); 7.383 (1.1); 7.378 (1.8); 7.375 (3.0); 7.368 (2.3); 7.365 (2.9); 7.363 (2.3); 7.360 (1.5); 7.356 (1.6); 7.353 (2.2); 7.346 (1.2); 7.343 (1.2); 7.261 (109.6); 7.007 (1.7); 7.004 (1.8); 7.000 (1.9); 6.998 (2.2); 6.985 (3.2); 6.983 (2.4); 6.981 (2.6); 6.979 (3.5); 6.966 (1.6); 6.963 (1.7); 6.959 (1.8); 6.957 (1.8); 6.912 (2.8); 6.905 (2.4); 6.890 (3.0); 6.886 (3.5); 6.880 (2.6); 6.865 (2.8); 6.858 (2.4); 5.235 (15.9); 5.233 (15.9); 4.268 (2.2); 4.258 (2.3); 4.246 (3.2); 4.234 (2.4); 4.223 (2.3); 3.371 (1.4); 3.367 (1.4); 3.349 (3.2); 3.336 (2.8); 3.322 (3.0); 3.306 (1.3); 3.301 (1.3); 2.380 (0.6); 2.373 (1.2); 2.366 (1.9); 2.358 (1.9); 2.352 (3.3); 2.338 (2.9); 2.333 (3.7); 2.320 (1.9); 2.311 (1.3); 2.306 (0.7); 2.078 (1.1); 2.064 (2.0); 2.060 (2.9); 2.052 (2.5); 2.043 (5.0); 2.040 (4.4); 2.033 (2.8); 2.025 (2.5); 2.010 (0.5); 2.005 (0.7); 1.635 (2.3); 1.258 (0.6); 0.008 (1.3); 0.000 (42.3); 0.009 (1.2)

Example No. A2-17

[0297] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.626 (3.1); 7.611 (5.3); 7.594 (4.4); 7.519 (1.8); 7.513 (2.1); 7.492 (3.9); 7.475 (2.1); 7.463 (2.2); 7.458 (2.0); 7.447 (1.4); 7.442 (4.2); 7.437 (1.4); 7.426 (2.0); 7.421 (2.3); 7.405 (1.2); 7.379 (2.4); 7.359 (3.4); 7.340 (1.5); 7.294 (0.6); 7.291 (0.5); 7.260 (290.3); 7.254 (1.4); 7.253 (0.7); 7.252 (0.6); 7.251 (0.5); 7.249 (0.5); 7.210 (1.8); 7.043 (6.4); 7.023 (9.0); 7.003 (5.5); 6.996 (2.5); 5.410 (16.0); 4.439 (2.0); 4.412 (2.6); 4.392 (2.1); 4.148 (0.6); 4.131 (1.6); 4.113 (1.6); 3.239 (1.2); 3.223 (2.5); 3.196 (2.4); 3.177 (1.2); 2.374 (1.5); 2.358 (2.7); 2.342 (2.7); 2.326 (1.5); 2.170 (0.6); 2.044 (7.7); 2.039 (0.9); 1.969 (2.2); 1.953 (3.8); 1.935 (2.0); 1.568 (6.0); 1.277 (2.3); 1.259 (4.8); 1.256 (1.2); 1.241 (2.3); 0.008 (3.8); 0.000 (130.2); 0.009 (3.6); 0.051 (0.9)

Example No. A2-21

[0298] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.632 (2.3); 8.630 (2.6); 8.628 (2.7); 8.626 (2.4); 8.620 (2.4); 8.618 (2.7); 8.614 (2.1); 7.792 (1.4); 7.788 (1.4); 7.773 (3.5); 7.769 (3.4); 7.755 (3.8); 7.751 (3.9); 7.743 (3.6); 7.739 (4.7); 7.737 (3.8); 7.724 (1.6); 7.721 (1.8); 7.717 (1.1); 7.602 (2.9); 7.583 (3.1); 7.520 (0.9); 7.429 (1.0); 7.411 (2.6); 7.392 (2.2); 7.351 (3.9); 7.347 (3.1); 7.339 (3.0); 7.333 (5.1); 7.329 (5.3); 7.321 (3.8); 7.317 (3.0); 7.312 (1.7); 7.308 (2.1); 7.284 (0.5); 7.282 (0.5); 7.279 (0.7); 7.261 (153.7); 7.254 (1.1); 7.253 (0.9); 6.997 (0.9); 5.298 (3.9); 5.272 (16.0); 4.289 (1.8); 3.668 (1.0); 3.653 (1.9); 3.639 (1.8); 3.631 (1.6); 3.625 (1.8); 3.609 (0.9); 2.342 (0.8); 2.335 (1.3); 2.328 (1.4); 2.321 (2.3); 2.308 (2.0); 2.302 (2.4); 2.290 (1.4); 2.282 (1.0); 2.085 (0.7); 2.072 (1.4); 2.067 (1.9); 2.059 (1.9); 2.049 (2.9); 2.040 (2.0); 2.032 (1.6); 1.599 (2.1); 1.255 (0.6); 0.008 (1.5); 0.000 (43.1); 0.009 (1.3)

Example No. A2-27

[0299] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.831 (11.6); 8.818 (11.7); 7.566 (2.0); 7.546 (2.3); 7.519 (1.9); 7.509 (1.2); 7.490 (1.8); 7.447 (1.1); 7.429 (1.9); 7.410 (0.9); 7.334 (2.7); 7.321 (3.8); 7.309 (2.5); 7.295 (0.9); 7.291 (0.7); 7.260 (286.8); 7.255 (1.5); 7.2543 (1.2); 7.2536 (0.8); 7.253 (0.8); 7.252 (0.7); 7.227 (0.5); 7.210 (1.7); 6.996 (1.5); 5.470 (16.0); 4.439 (1.5); 3.732 (1.4); 2.358 (1.7); 2.340 (1.8); 2.326 (1.0); 2.052 (2.0); 2.044 (1.6); 2.018 (1.9); 1.573 (5.1); 1.259 (0.8); 1.256 (1.0); 0.008 (3.5); 0.000 (121.1); 0.009 (3.4); 0.050 (0.7)

Example No. A2-37

[0300] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.275 (2.0); 7.610 (0.9); 7.590 (1.0); 7.469 (1.8); 7.467 (1.8); 7.461 (1.1); 7.454 (1.0); 7.262 (17.7); 5.305 (4.8); 5.298 (3.5); 4.396 (0.5); 3.800 (16.0); 3.585 (0.5); 3.558 (0.5); 2.558 (9.2); 2.295 (8.5); 2.278 (0.7); 2.043 (0.8); 1.864 (0.8); 1.258 (0.5); 0.000 (5.5)

Example No. A2-40

[0301] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.474 (4.8); 8.461 (5.0); 7.604 (1.8); 7.585 (2.0); 7.534 (0.8); 7.519 (1.7); 7.514 (1.6); 7.487 (1.2); 7.480 (5.0); 7.467 (6.1); 7.450 (0.8); 7.369 (0.9); 7.350 (1.3); 7.331 (0.6); 7.273 (0.5); 7.272 (0.6); 7.271 (0.6); 7.270 (0.8); 7.2693 (0.8); 7.2685 (0.9); 7.268 (1.2); 7.267 (1.3); 7.266 (1.6); 7.2653 (2.0); 7.2645 (2.6); 7.260 (141.7); 7.256 (1.1); 7.255 (0.8); 7.254 (0.6); 7.210 (0.8); 6.996 (0.8); 5.624 (16.0); 4.470 (1.0); 3.629 (1.2); 3.615 (1.0); 3.601 (1.1); 3.585 (0.5); 2.956 (2.7); 2.955 (2.7); 2.884 (2.4); 2.883 (2.3); 2.367 (0.7); 2.352 (1.3); 2.334 (1.4); 2.321 (0.7); 1.970 (1.0); 1.953 (1.6); 1.937 (0.8); 1.577 (6.7); 1.256 (0.6); 0.008 (1.6); 0.006 (0.5); 0.000 (58.8); 0.009 (1.6)

Example No. A2-61

[0302] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.019 (1.5); 8.014 (1.3); 7.993 (1.0); 7.755 (0.7); 7.752 (0.9); 7.735 (0.9); 7.733 (1.1); 7.727 (0.7); 7.724 (0.6); 7.708 (1.2); 7.704 (1.0); 7.688 (0.7); 7.685 (0.7); 7.650 (0.9); 7.631 (0.9); 7.575 (0.9); 7.571 (1.0); 7.555 (1.3); 7.552 (1.3); 7.542 (0.6); 7.536 (0.7); 7.533 (0.6); 7.525 (1.0); 7.520 (0.9); 7.501 (0.6); 7.484 (0.8); 7.406 (0.5); 7.404 (0.5); 7.386 (0.8); 7.268 (0.5); 7.267 (0.6); 7.2663 (0.8); 7.2655 (0.9); 7.261 (87.9); 7.2574 (2.5); 7.2565 (2.1); 7.256 (1.9); 7.253 (0.6); 5.438 (3.5); 4.272 (0.6); 3.480 (0.7); 3.458 (0.5); 3.452 (0.6); 2.956 (16.0); 2.955 (15.6); 2.884 (14.2); 2.883 (14.2); 2.367 (0.7); 2.349 (0.7); 2.137 (0.5); 2.119 (0.8); 2.044 (1.3); 1.568 (1.5); 1.259 (0.8); 0.008 (1.1); 0.000 (37.1); 0.004 (1.1); 0.005 (1.0); 0.007 (0.5); 0.009 (1.2)

Example No. A2-62

[0303] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.860 (3.7); 7.857 (7.4); 7.853 (4.8); 7.836 (2.9); 7.832 (3.8); 7.828 (2.2); 7.816 (3.2); 7.813 (4.3); 7.809 (2.8); 7.744 (2.9); 7.740 (4.3); 7.737 (2.7); 7.724 (3.7); 7.721 (5.2); 7.717 (3.2); 7.628 (4.0); 7.609 (4.8); 7.572 (4.5); 7.553 (7.3); 7.534 (3.2); 7.520 (1.9); 7.500 (3.6); 7.483 (4.5); 7.480 (4.4); 7.476 (4.6); 7.471 (5.9); 7.456 (1.8); 7.397 (1.7); 7.395 (2.1); 7.392 (2.1); 7.377 (3.0); 7.375 (3.2); 7.373 (2.9); 7.360 (1.1); 7.358 (1.3); 7.355 (1.4); 7.261 (151.2); 7.211 (1.0); 6.997 (0.9); 5.217 (16.0); 4.285 (1.8); 4.263 (2.8); 4.241 (2.0); 3.346 (1.2); 3.340 (1.3); 3.331 (1.4); 3.324 (3.3); 3.318 (2.3); 3.309 (2.4); 3.302 (2.5); 3.296 (3.2); 3.280 (1.4); 3.274 (1.3); 2.955 (1.0); 2.884 (0.9); 2.404 (1.1); 2.397 (1.6); 2.390 (1.6); 2.383 (2.9); 2.369 (2.5); 2.364 (3.3); 2.351 (1.7); 2.342 (1.2); 2.103 (1.0); 2.090 (1.7); 2.085 (2.5); 2.077 (2.1); 2.069 (3.9); 2.065 (3.8); 2.058 (2.4); 2.050 (2.1); 2.044 (1.6); 2.029 (1.3); 1.582 (2.5); 1.256 (1.3); 0.008 (1.9); 0.000 (65.4); 0.009 (1.9)

Example No. A2-63

[0304] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.739 (3.7); 7.737 (2.5); 7.734 (1.6); 7.723 (2.7); 7.718 (11.7); 7.698 (11.1); 7.693 (2.2); 7.682 (1.5); 7.677 (3.4); 7.632 (2.3); 7.612 (2.5); 7.519 (1.5); 7.496 (0.9); 7.477 (2.1); 7.459 (1.9); 7.410 (2.9); 7.395 (2.3); 7.378 (1.9); 7.360 (0.9); 7.279 (0.5); 7.278 (0.5); 7.277 (0.6); 7.276 (0.6); 7.2754 (0.7); 7.2747 (0.7); 7.274 (0.8); 7.273 (0.7); 7.2722 (0.9); 7.2715 (1.0); 7.271 (1.1); 7.270 (1.4); 7.269 (1.5); 7.268 (1.7); 7.2674 (2.0); 7.2667 (2.4); 7.266 (2.7); 7.265 (3.4); 7.264 (4.4); 7.260 (247.9); 7.257 (3.3); 7.256 (2.0); 7.255 (1.4); 7.2544 (1.1); 7.2536 (0.8); 7.253 (0.7); 7.252 (0.6); 7.210 (1.1); 6.996 (1.4); 5.238 (9.5); 4.283 (1.5); 4.260 (1.1); 3.335 (0.7); 3.320 (1.7); 3.304 (1.3); 3.297 (1.3); 3.291 (1.6); 3.276 (0.8); 3.270 (0.7); 2.389 (0.9); 2.375 (1.6); 2.360 (1.4); 2.356 (1.8); 2.343 (0.9); 2.089 (0.5); 2.071 (1.4); 2.054 (2.1); 2.044 (1.4); 2.035 (1.2); 1.555 (16.0); 0.008 (3.1); 0.000 (110.0); 0.006 (0.7); 0.009 (3.0)

Example No. A2-81

[0305] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.206 (3.8); 8.186 (4.0); 7.748 (3.5); 7.728 (4.2); 7.664 (4.1); 7.645 (4.8); 7.636 (1.9); 7.615 (6.0); 7.595 (6.4); 7.576 (0.7); 7.570 (0.6); 7.557 (0.5); 7.539 (4.9); 7.520 (8.0); 7.502 (3.1); 7.424 (2.3); 7.405 (3.6); 7.386 (1.5); 7.270 (0.9); 7.267 (1.2); 7.261 (145.7); 7.253 (0.6); 7.211 (0.9); 6.997 (0.8); 5.475 (16.0); 4.297 (2.5); 4.274 (1.9); 3.262 (1.2); 3.257 (1.3); 3.240 (3.0); 3.225 (2.4); 3.218 (2.5); 3.213 (2.9); 3.196 (1.4); 3.190 (1.4); 3.010 (0.9); 2.955 (1.1); 2.882 (0.9); 2.370 (1.0); 2.363 (1.6); 2.348 (2.8); 2.330 (3.0); 2.316 (1.6); 2.308 (1.2); 2.044 (0.7); 2.038 (0.9); 2.019 (2.4); 2.004 (4.1); 2.000 (4.0); 1.993 (2.3); 1.985 (2.2); 1.965 (0.7); 1.923 (0.6); 1.914 (1.3); 1.904 (0.6); 1.655 (0.5); 1.585 (8.6); 1.256 (1.1); 0.008 (1.8); 0.000 (64.0); 0.009 (1.8)

Example No. A2-121

[0306] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 9.254 (4.7); 8.006 (1.9); 8.005 (1.8); 8.004 (2.0); 7.986 (2.1); 7.984 (2.1); 7.854 (1.7); 7.852 (1.7); 7.833 (2.4); 7.831 (2.4); 7.801 (4.4); 7.747 (1.7); 7.743 (1.7); 7.729 (2.4); 7.726 (3.2); 7.723 (1.2); 7.709 (1.8); 7.706 (1.7); 7.655 (2.0); 7.652 (2.0); 7.637 (1.5); 7.634 (3.0); 7.631 (1.8); 7.617 (1.3); 7.614 (1.2); 7.267 (0.6); 7.266 (0.7); 7.261 (50.3); 4.857 (16.0); 1.604 (1.5); 0.008 (0.6); 0.000 (17.8)

Example No. A2-122

[0307] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 10.244 (12.5); 10.241 (12.8); 8.339 (4.2); 8.318 (4.9); 8.279 (1.8); 8.277 (3.3); 8.275 (3.3); 8.273 (1.8); 8.258 (2.0); 8.256 (3.6); 8.253 (3.6); 8.251 (1.9); 8.058 (9.2); 8.037 (7.9); 7.932 (2.7); 7.930 (2.7); 7.928 (2.9); 7.912 (3.3); 7.908 (3.5); 7.860 (2.4); 7.856 (2.4); 7.843 (3.2); 7.839 (4.7); 7.835 (2.2); 7.821 (2.9); 7.818 (2.6); 7.724 (3.4); 7.721 (3.5); 7.707 (2.8); 7.703 (5.3); 7.700 (3.0); 7.686 (2.2); 7.683 (2.2); 7.520 (0.6); 7.271 (0.6); 7.261 (100.2); 6.997 (0.6); 6.560 (2.0); 1.566 (1.5); 1.422 (2.4); 1.221 (16.0); 0.008 (1.1); 0.005 (0.6); 0.004 (0.7); 0.000 (35.6); 0.009 (1.0);

Example No. A2-144

[0308] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.805 (2.3); 7.799 (1.5); 7.794 (1.3); 7.791 (1.8); 7.789 (1.7); 7.782 (2.5); 7.644 (1.8); 7.643 (1.9); 7.642 (1.8); 7.623 (2.2); 7.622 (2.0); 7.595 (1.6); 7.576 (2.4); 7.514 (1.2); 7.513 (1.2); 7.496 (2.2); 7.494 (2.1); 7.477 (1.2); 7.474 (2.2); 7.468 (1.2); 7.465 (1.2); 7.460 (1.0); 7.455 (1.3); 7.450 (2.6); 7.402 (1.4); 7.400 (1.3); 7.399 (1.3); 7.396 (1.6); 7.384 (4.9); 7.379 (5.4); 7.377 (4.8); 7.369 (6.4); 7.362 (3.4); 7.359 (3.6); 7.356 (3.0); 7.343 (0.7); 7.2683 (0.6); 7.2675 (0.7); 7.267 (1.0); 7.263 (25.6); 7.260 (0.6); 5.407 (16.0); 5.300 (2.8); 4.327 (1.0); 4.305 (1.4); 4.283 (1.1); 3.396 (0.8); 3.390 (0.8); 3.374 (1.8); 3.368 (1.4); 3.361 (1.4); 3.358 (1.4); 3.351 (1.5); 3.346 (1.7); 3.330 (0.8); 3.323 (0.8); 2.362 (0.6); 2.354 (0.9); 2.347 (1.0); 2.340 (1.7); 2.338 (1.7); 2.332 (1.2); 2.326 (1.5); 2.322 (1.8); 2.314 (0.9); 2.309 (0.9); 2.300 (0.7); 2.046 (0.7); 2.040 (0.6); 2.026 (1.1); 2.021 (1.5); 2.012 (1.3); 2.005 (2.4); 2.002 (2.3); 1.995 (1.3); 1.987 (1.2); 1.664 (0.6); 0.000 (9.1)

Example No. A2-462

[0309] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 7.952 (2.2); 7.627 (0.6); 7.591 (3.6); 7.570 (4.6); 7.557 (1.8); 7.539 (3.9); 7.521 (2.5); 7.440 (2.3); 7.421 (3.4); 7.403 (1.4); 7.370 (0.9); 7.354 (1.8); 7.350 (1.6); 7.333 (3.5); 7.315 (5.5); 7.295 (4.2); 7.110 (4.7); 7.090 (7.6); 7.069 (3.9); 4.066 (2.9); 4.042 (2.2); 3.983 (3.2); 3.963 (2.9); 3.942 (3.3); 3.364 (0.8); 3.315 (142.2); 3.282 (0.7); 3.266 (1.7); 3.221 (2.3); 2.890 (16.0); 2.730 (13.6); 2.693 (2.8); 2.674 (6.3); 2.655 (3.2); 2.550 (1.8); 2.546 (1.8); 2.510 (77.0); 2.505 (162.0); 2.501 (222.4); 2.496 (158.9); 2.492 (73.9); 2.328 (1.2); 2.047 (3.6); 2.027 (4.8); 2.007 (3.9); 1.988 (3.0); 1.950 (2.5); 1.940 (2.9); 1.235 (0.8); 1.175 (0.7); 0.008 (3.0); 0.000 (87.2); 0.009 (3.0)

Example No. A2-603

[0310] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.017 (1.7); 7.998 (2.0); 7.902 (1.8); 7.882 (2.2); 7.637 (1.8); 7.618 (3.0); 7.600 (2.3); 7.581 (2.6); 7.562 (2.3); 7.504 (2.1); 7.485 (3.5); 7.465 (1.8); 7.390 (1.1); 7.370 (1.7); 7.352 (0.9); 7.260 (54.0); 7.210 (0.5); 5.760 (7.9); 4.215 (1.9); 3.937 (16.0); 3.337 (1.8); 2.286 (1.9); 1.982 (2.4); 1.563 (4.6); 0.000 (23.6)

Example No. A2-679

[0311] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.770 (5.5); 8.766 (5.8); 8.758 (5.7); 8.754 (5.7); 8.357 (4.3); 8.353 (4.4); 8.337 (4.7); 8.333 (4.5); 8.020 (0.6); 7.669 (3.7); 7.649 (4.4); 7.628 (5.4); 7.617 (5.2); 7.608 (5.1); 7.596 (5.0); 7.520 (1.6); 7.516 (0.5); 7.496 (3.4); 7.493 (4.3); 7.490 (5.0); 7.482 (13.3); 7.480 (12.9); 7.471 (0.9); 7.430 (1.7); 7.428 (1.8); 7.421 (2.2); 7.414 (1.3); 7.411 (1.9); 7.409 (2.1); 7.400 (1.8); 7.395 (0.9); 7.389 (0.9); 7.387 (0.9); 7.273 (0.9); 7.270 (1.4); 7.269 (1.5); 7.268 (1.8); 7.267 (2.1); 7.266 (2.5); 7.261 (243.5); 7.256 (2.4); 7.255 (1.6); 7.254 (1.1); 7.253 (0.8); 7.2524 (0.7); 7.2517 (0.6); 7.251 (0.5); 7.250 (0.5); 7.211 (1.6); 6.997 (1.3); 5.472 (16.0); 4.287 (1.7); 4.277 (1.7); 4.265 (2.5); 4.253 (1.9); 4.243 (1.8); 3.559 (1.2); 3.552 (1.2); 3.537 (2.9); 3.531 (2.0); 3.522 (2.2); 3.515 (2.2); 3.509 (2.7); 3.493 (1.3); 3.487 (1.2); 2.955 (6.8); 2.930 (0.5); 2.884 (5.8); 2.883 (5.9); 2.412 (0.9); 2.405 (1.4); 2.398 (1.4); 2.389 (2.6); 2.376 (2.3); 2.372 (2.6); 2.359 (1.7); 2.324 (0.7); 2.215 (0.9); 2.197 (2.2); 2.177 (3.7); 2.170 (2.2); 2.162 (1.8); 2.142 (0.6); 2.051 (0.7); 1.565 (6.5); 1.256 (2.1); 0.008 (3.0); 0.000 (103.9); 0.007 (0.8); 0.009 (3.0); 0.050 (0.7)

Example No. A3-21

[0312] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.646 (0.9); 8.644 (0.9); 8.634 (0.9); 8.632 (0.9); 7.770 (1.2); 7.765 (1.2); 7.751 (0.9); 7.747 (0.9); 7.716 (1.6); 7.696 (0.9); 7.596 (1.0); 7.576 (1.1); 7.405 (1.0); 7.386 (0.8); 7.355 (1.2); 7.352 (1.3); 7.343 (0.8); 7.339 (1.0); 7.336 (1.4); 7.333 (1.5); 7.324 (0.7); 7.321 (0.7); 7.263 (22.1); 7.247 (0.9); 5.530 (1.2); 5.501 (1.4); 5.300 (1.6); 5.156 (1.1); 5.127 (0.9); 4.483 (0.5); 4.249 (0.6); 4.244 (0.5); 4.239 (0.5); 4.234 (0.6); 3.899 (0.7); 3.890 (0.9); 3.871 (0.5); 3.346 (16.0); 0.000 (6.2)

Example No. A4-1

[0313] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.750 (3.3); 7.746 (2.4); 7.732 (3.9); 7.727 (2.6); 7.678 (4.7); 7.677 (4.8); 7.659 (5.1); 7.658 (5.2); 7.656 (5.2); 7.504 (1.8); 7.484 (4.6); 7.479 (4.0); 7.475 (2.5); 7.463 (3.8); 7.460 (5.0); 7.456 (3.2); 7.410 (2.3); 7.402 (1.2); 7.398 (2.4); 7.393 (4.0); 7.383 (2.7); 7.379 (4.3); 7.375 (3.5); 7.364 (1.9); 7.360 (3.9); 7.355 (5.0); 7.350 (2.3); 7.336 (4.1); 7.332 (2.3); 7.318 (1.4); 7.314 (0.8); 7.267 (9.7); 7.266 (9.3); 7.264 (10.8); 7.263 (14.9); 5.324 (16.0); 5.300 (2.5); 5.299 (2.5); 5.297 (2.8); 5.295 (4.0); 4.477 (1.8); 4.456 (1.8); 3.006 (2.1); 3.002 (2.1); 2.974 (4.3); 2.945 (2.4); 2.398 (0.5); 2.389 (0.9); 2.380 (0.6); 2.356 (2.5); 2.322 (2.5); 2.297 (0.6); 2.289 (1.0); 2.280 (0.5); 2.042 (0.9); 1.808 (1.3); 1.777 (1.4); 1.693 (1.3); 1.661 (3.0); 1.625 (2.7); 1.348 (0.6); 1.338 (0.4); 1.325 (0.9); 1.315 (1.5); 1.305 (0.8); 1.292 (0.9); 1.281 (1.4); 1.275 (0.9); 1.272 (0.8); 1.259 (0.7); 1.257 (0.9); 1.249 (0.5); 1.241 (0.4); 1.240 (0.5); 0.004 (3.3); 0.003 (3.2); 0.002 (3.6)

Example No. A6-1

[0314] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.762 (2.5); 7.757 (1.8); 7.755 (1.6); 7.744 (3.2); 7.738 (2.7); 7.599 (1.3); 7.585 (1.4); 7.578 (1.5); 7.564 (1.4); 7.484 (1.1); 7.483 (1.0); 7.477 (2.3); 7.473 (3.3); 7.469 (1.2); 7.467 (0.6); 7.460 (3.1); 7.458 (2.7); 7.454 (3.5); 7.414 (1.0); 7.405 (1.5); 7.403 (1.5); 7.400 (1.3); 7.398 (2.1); 7.391 (1.6); 7.385 (3.6); 7.379 (3.3); 7.370 (3.4); 7.367 (3.6); 7.364 (3.6); 7.360 (2.7); 7.351 (4.9); 7.347 (3.2); 7.344 (2.4); 7.333 (1.2); 7.327 (2.2); 7.320 (2.2); 7.298 (0.6); 7.288 (4.1); 7.280 (2.9); 7.274 (2.7); 7.265 (5.0); 7.261 (82.3); 7.257 (1.0); 7.256 (0.8); 7.255 (0.8); 7.205 (1.0); 7.1984 (0.9); 7.1976 (0.9); 7.184 (1.9); 7.177 (1.7); 7.164 (0.9); 7.157 (0.8); 5.382 (16.0); 5.298 (3.8); 4.709 (11.2); 4.303 (1.0); 4.281 (1.4); 4.259 (1.0); 3.394 (0.7); 3.388 (0.8); 3.378 (0.7); 3.372 (1.7); 3.366 (1.3); 3.359 (1.3); 3.356 (1.4); 3.349 (1.4); 3.344 (1.7); 3.327 (0.8); 3.321 (0.7); 2.339 (0.6); 2.332 (0.9); 2.324 (0.9); 2.318 (1.6); 2.316 (1.6); 2.309 (1.1); 2.303 (1.4); 2.299 (1.7); 2.286 (0.9); 2.277 (0.7); 2.039 (0.5); 2.025 (1.0); 2.021 (1.4); 2.011 (1.2); 2.005 (2.3); 2.001 (2.2); 1.994 (1.3); 1.986 (1.2); 1.610 (1.2); 1.432 (1.7); 1.416 (0.5); 1.257 (1.6); 1.221 (3.6); 0.008 (0.8); 0.000 (28.3); 0.009 (0.8)

Example No. A6-21

[0315] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.638 (2.2); 8.636 (2.4); 8.634 (2.5); 8.631 (2.2); 8.626 (2.3); 8.624 (2.5); 8.622 (2.4); 8.619 (2.1); 7.783 (1.7); 7.778 (1.7); 7.764 (4.0); 7.759 (3.9); 7.744 (3.0); 7.740 (2.9); 7.698 (3.1); 7.696 (4.7); 7.693 (3.1); 7.679 (2.0); 7.677 (2.8); 7.674 (1.7); 7.520 (0.9); 7.356 (2.2); 7.353 (2.1); 7.344 (2.2); 7.341 (2.2); 7.337 (2.2); 7.334 (2.1); 7.325 (2.7); 7.322 (3.0); 7.311 (4.5); 7.305 (3.8); 7.288 (3.7); 7.282 (3.1); 7.277 (0.7); 7.276 (0.6); 7.2753 (0.6); 7.2745 (0.7); 7.274 (0.7); 7.273 (0.7); 7.272 (0.7); 7.2713 (0.8); 7.2705 (0.9); 7.270 (1.0); 7.269 (1.1); 7.268 (1.3); 7.267 (1.6); 7.261 (151.1); 7.258 (2.9); 7.257 (1.9); 7.256 (1.4); 7.255 (1.1); 7.2544 (0.8); 7.2535 (0.7); 7.253 (0.5); 7.122 (1.2); 7.116 (1.1); 7.101 (2.0); 7.095 (1.9); 7.081 (1.0); 7.074 (0.9); 6.997 (0.8); 6.978 (0.6); 5.298 (7.7); 5.248 (16.0); 5.004 (0.6); 4.274 (1.5); 3.680 (0.8); 3.664 (1.8); 3.649 (1.7); 3.642 (1.4); 3.635 (1.6); 3.620 (0.8); 2.325 (0.7); 2.318 (1.1); 2.311 (1.2); 2.303 (2.0); 2.290 (1.8); 2.284 (2.1); 2.272 (2.1); 2.271 (2.4); 2.264 (0.9); 2.090 (0.7); 2.076 (1.3); 2.072 (1.7); 2.064 (1.6); 2.053 (2.6); 2.045 (1.8); 2.037 (1.4); 2.030 (0.9); 1.610 (1.9); 1.432 (13.5); 1.257 (2.2); 1.244 (0.5); 1.221 (2.6); 0.880 (0.6); 0.008 (1.4); 0.000 (51.6); 0.009 (1.5)

Example No. A6-37

[0316] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.276 (1.4); 7.315 (0.5); 7.298 (0.5); 7.292 (0.5); 7.2674 (0.5); 7.2665 (0.7); 7.263 (28.7); 5.301 (1.9); 5.278 (3.2); 3.798 (16.0); 2.545 (6.6); 2.298 (5.6); 1.871 (0.6); 0.000 (8.5)

Example No. A6-121

[0317] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.248 (6.2); 8.227 (7.1); 8.205 (0.8); 8.088 (6.5); 8.067 (7.4); 7.882 (6.9); 7.863 (8.0); 7.825 (0.9); 7.804 (7.1); 7.782 (9.0); 7.761 (6.2); 7.740 (3.8); 7.626 (4.3); 7.607 (6.2); 7.588 (3.3); 7.571 (0.9); 7.520 (10.7); 7.386 (2.7); 7.381 (3.0); 7.361 (2.2); 7.318 (4.2); 7.312 (3.7); 7.308 (2.3); 7.303 (3.9); 7.302 (4.0); 7.301 (4.0); 7.3004 (4.0); 7.2996 (4.5); 7.299 (4.7); 7.298 (4.5); 7.2973 (4.6); 7.2965 (4.3); 7.296 (4.3); 7.295 (4.2); 7.294 (4.4); 7.2934 (4.1); 7.2925 (3.8); 7.292 (3.7); 7.291 (3.4); 7.290 (2.5); 7.289 (3.6); 7.288 (3.6); 7.287 (3.8); 7.2844 (2.5); 7.2838 (3.5); 7.282 (1.5); 7.2813 (1.8); 7.2806 (2.6); 7.280 (2.6); 7.279 (2.8); 7.278 (2.7); 7.2774 (3.3); 7.2766 (3.8); 7.276 (4.2); 7.275 (4.9); 7.274 (5.4); 7.2734 (5.4); 7.2726 (6.0); 7.272 (5.6); 7.271 (7.1); 7.270 (8.5); 7.2694 (9.6); 7.2687 (11.5); 7.268 (11.9); 7.267 (14.7); 7.266 (18.1); 7.2654 (25.4); 7.2646 (37.1); 7.261 (1809.1); 7.258 (47.0); 7.257 (32.4); 7.2564 (23.7); 7.2556 (15.4); 7.255 (10.9); 7.254 (7.4); 7.253 (6.5); 7.2524 (5.4); 7.2516 (5.0); 7.251 (4.9); 7.250 (3.5); 7.249 (3.3); 7.2484 (2.6); 7.2476 (2.5); 7.247 (2.5); 7.246 (2.4); 7.245 (2.6); 7.2444 (2.9); 7.2437 (2.3); 7.243 (2.1); 7.242 (2.0); 7.2412 (2.5); 7.2405 (2.6); 7.240 (2.8); 7.238 (1.9); 7.237 (3.9); 7.2332 (1.7); 7.2326 (1.3); 7.232 (1.0); 7.231 (0.8); 7.230 (0.9); 7.229 (0.8); 7.228 (1.2); 7.227 (1.3); 7.226 (1.1); 7.225 (0.8); 7.222 (1.1); 7.221 (0.8); 7.214 (0.7); 7.213 (0.8); 7.211 (3.1); 7.209 (0.6); 7.206 (0.6); 7.204 (0.6); 7.202 (0.6); 7.161 (1.4); 7.138 (1.9); 7.111 (3.4); 7.092 (2.0); 6.997 (10.6); 5.441 (16.0); 5.301 (6.6); 4.850 (3.9); 4.297 (3.9); 3.762 (3.9); 3.649 (0.5); 3.119 (0.6); 3.104 (0.6); 2.303 (4.5); 2.088 (6.0); 2.010 (0.7); 1.921 (0.5); 1.563 (29.4); 1.432 (7.8); 1.419 (1.8); 1.401 (0.9); 1.255 (7.3); 1.222 (2.8); 0.880 (2.0); 0.852 (1.6); 0.146 (1.7); 0.069 (11.0); 0.008 (14.8); 0.005 (1.3); 0.000 (660.7); 0.007 (7.4); 0.009 (20.8); 0.0116 (3.5); 0.0124 (3.1); 0.013 (2.7); 0.014 (2.4); 0.015 (2.4); 0.016 (2.2); 0.0165 (2.3); 0.0172 (2.1); 0.018 (2.0); 0.019 (1.9); 0.020 (1.9); 0.021 (2.0); 0.024 (2.3); 0.026 (1.2); 0.028 (1.5); 0.030 (1.1); 0.035 (1.2); 0.040 (1.0); 0.051 (1.5); 0.101 (0.6); 0.123 (0.5); 0.150 (1.8)

Example No. A7-1

[0318] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.878 (2.5); 7.872 (1.5); 7.867 (2.4); 7.863 (1.8); 7.855 (2.7); 7.519 (0.9); 7.496 (2.3); 7.489 (1.8); 7.487 (1.7); 7.483 (1.7); 7.478 (1.9); 7.473 (2.7); 7.451 (2.1); 7.444 (1.7); 7.439 (2.7); 7.433 (1.7); 7.427 (3.6); 7.419 (0.6); 7.373 (1.1); 7.368 (0.6); 7.362 (5.3); 7.360 (5.2); 7.355 (4.1); 7.350 (6.6); 7.348 (4.4); 7.345 (3.3); 7.343 (3.8); 7.340 (2.9); 7.337 (6.8); 7.333 (2.6); 7.328 (3.7); 7.327 (3.7); 7.317 (0.6); 7.260 (157.5); 7.231 (1.2); 7.218 (4.2); 7.214 (4.7); 7.213 (4.0); 7.211 (2.0); 7.205 (7.5); 7.195 (4.2); 7.191 (2.9); 7.178 (0.7); 6.996 (0.9); 5.401 (16.0); 4.829 (1.3); 4.337 (1.5); 4.318 (1.1); 3.411 (0.7); 3.405 (0.8); 3.388 (1.7); 3.383 (1.4); 3.373 (1.4); 3.366 (1.5); 3.361 (1.7); 3.345 (0.9); 3.338 (0.8); 2.955 (1.0); 2.884 (0.8); 2.883 (0.8); 2.409 (0.9); 2.393 (1.7); 2.381 (1.6); 2.378 (1.8); 2.364 (0.9); 2.355 (0.7); 2.076 (0.5); 2.058 (1.5); 2.049 (1.3); 2.042 (2.5); 2.038 (2.4); 2.032 (1.4); 2.024 (1.3); 1.581 (2.3); 0.008 (1.7); 0.005 (0.6); 0.000 (61.2); 0.005 (1.1); 0.006 (1.0); 0.007 (0.9); 0.009 (2.1)

Example No. A7-2

[0319] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.584 (3.8); 7.580 (7.3); 7.575 (4.2); 7.520 (0.8); 7.461 (2.3); 7.457 (3.6); 7.451 (4.4); 7.445 (3.4); 7.442 (5.0); 7.438 (6.3); 7.433 (4.3); 7.428 (4.7); 7.415 (1.9); 7.411 (2.4); 7.406 (2.2); 7.395 (4.6); 7.391 (4.0); 7.390 (4.7); 7.386 (3.3); 7.359 (6.3); 7.340 (6.3); 7.334 (3.9); 7.329 (3.1); 7.325 (2.8); 7.318 (3.6); 7.316 (3.5); 7.311 (5.3); 7.300 (0.7); 7.261 (138.1); 7.227 (0.8); 7.222 (1.8); 7.209 (6.1); 7.203 (9.5); 7.194 (11.7); 7.186 (6.7); 7.179 (4.2); 7.167 (1.2); 7.161 (0.8); 6.997 (0.8); 5.143 (16.0); 4.829 (1.3); 4.335 (1.5); 4.313 (2.3); 4.290 (1.6); 3.326 (1.1); 3.320 (1.1); 3.304 (2.5); 3.289 (2.1); 3.276 (2.5); 3.260 (1.2); 3.254 (1.1); 2.955 (2.4); 2.884 (2.0); 2.883 (2.0); 2.433 (0.9); 2.425 (1.4); 2.418 (1.4); 2.412 (2.6); 2.397 (2.3); 2.393 (2.9); 2.380 (1.5); 2.370 (1.1); 2.080 (0.8); 2.062 (2.3); 2.053 (2.0); 2.043 (3.7); 2.035 (2.1); 2.027 (2.1); 2.020 (4.1); 2.008 (0.6); 1.255 (1.0); 0.008 (1.4); 0.000 (53.4); 0.009 (1.5)

Example No. A7-5

[0320] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.864 (6.3); 7.844 (6.8); 7.519 (1.0); 7.468 (3.1); 7.467 (3.3); 7.459 (8.4); 7.457 (4.3); 7.454 (8.0); 7.451 (3.5); 7.445 (3.9); 7.353 (3.0); 7.347 (6.5); 7.341 (6.9); 7.337 (2.9); 7.3303 (4.4); 7.3296 (4.2); 7.325 (4.4); 7.320 (4.2); 7.273 (0.6); 7.271 (0.8); 7.270 (0.8); 7.269 (0.9); 7.268 (1.1); 7.2674 (1.2); 7.2666 (1.4); 7.266 (1.8); 7.265 (2.2); 7.260 (175.4); 7.257 (4.3); 7.256 (3.1); 7.255 (2.4); 7.2544 (2.0); 7.2536 (1.7); 7.253 (1.4); 7.252 (1.2); 7.251 (1.1); 7.2504 (1.0); 7.2496 (0.9); 7.249 (0.8); 7.248 (0.7); 7.233 (1.3); 7.228 (0.6); 7.221 (7.6); 7.220 (7.3); 7.214 (4.5); 7.210 (6.4); 7.208 (5.5); 7.204 (4.3); 7.198 (5.4); 7.197 (5.4); 7.185 (0.8); 6.996 (0.9); 5.352 (16.0); 4.332 (1.3); 4.308 (1.8); 4.283 (1.4); 3.411 (0.9); 3.405 (0.9); 3.389 (2.0); 3.383 (1.6); 3.374 (1.6); 3.367 (1.7); 3.361 (2.0); 3.345 (1.0); 3.339 (0.9); 2.955 (0.6); 2.884 (0.5); 2.883 (0.5); 2.415 (1.0); 2.401 (1.8); 2.387 (1.7); 2.383 (2.0); 2.370 (1.1); 2.360 (0.8); 2.106 (0.6); 2.088 (1.7); 2.079 (1.5); 2.072 (2.7); 2.068 (2.7); 2.061 (1.6); 2.053 (1.5); 2.044 (1.1); 1.586 (0.8); 1.259 (0.6); 0.008 (2.0); 0.006 (0.6); 0.0054 (0.7); 0.0046 (0.9); 0.004 (1.1); 0.000 (68.9); 0.003 (3.4); 0.004 (1.5); 0.005 (1.1); 0.006 (1.0); 0.007 (0.9); 0.009 (2.2)

Example No. A7-6

[0321] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.912 (6.0); 7.906 (6.1); 7.554 (2.8); 7.548 (3.3); 7.535 (2.5); 7.531 (3.3); 7.519 (0.9); 7.379 (3.5); 7.357 (9.9); 7.353 (3.8); 7.349 (2.9); 7.347 (2.7); 7.338 (6.3); 7.334 (6.7); 7.332 (7.0); 7.330 (5.6); 7.317 (2.1); 7.310 (2.2); 7.260 (157.3); 7.240 (3.8); 7.236 (3.9); 7.223 (4.7); 7.218 (4.9); 7.210 (1.3); 7.206 (2.8); 7.201 (2.5); 7.188 (0.9); 7.183 (0.7); 6.996 (0.8); 5.350 (16.0); 4.324 (1.9); 3.447 (1.0); 3.440 (1.0); 3.424 (2.3); 3.410 (1.9); 3.397 (2.3); 3.381 (1.1); 3.375 (1.0); 2.445 (0.9); 2.437 (1.2); 2.423 (2.2); 2.408 (2.1); 2.405 (2.4); 2.390 (1.3); 2.382 (1.0); 2.125 (0.7); 2.107 (2.0); 2.090 (3.2); 2.080 (1.7); 2.072 (1.7); 2.053 (0.5); 2.044 (1.3); 1.577 (4.9); 1.259 (0.8); 1.256 (0.5); 0.008 (1.5); 0.000 (57.8); 0.009 (1.7)

Example No. A7-7

[0322] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.520 (0.8); 7.515 (3.3); 7.509 (3.9); 7.499 (2.5); 7.496 (2.9); 7.492 (3.9); 7.474 (8.4); 7.472 (9.2); 7.453 (16.0); 7.366 (7.1); 7.348 (7.3); 7.344 (6.7); 7.331 (5.1); 7.326 (8.4); 7.262 (109.8); 7.245 (1.1); 7.241 (1.9); 7.226 (4.9); 7.222 (4.8); 7.215 (4.7); 7.210 (6.1); 7.208 (6.2); 7.204 (4.3); 7.196 (4.1); 7.191 (3.5); 7.178 (1.2); 7.172 (0.9); 6.998 (0.6); 5.762 (15.2); 4.676 (2.3); 4.656 (1.7); 3.057 (1.2); 3.037 (2.7); 3.030 (2.1); 3.022 (2.1); 3.015 (2.5); 2.995 (1.2); 2.989 (1.1); 2.422 (0.9); 2.414 (1.3); 2.402 (1.9); 2.395 (2.5); 2.383 (2.6); 2.376 (2.1); 2.363 (1.4); 2.007 (0.9); 1.923 (0.9); 1.909 (2.1); 1.890 (3.9); 1.876 (1.7); 1.870 (1.7); 1.616 (0.7); 1.255 (0.7); 0.008 (1.3); 0.000 (40.7); 0.008 (1.3)

Example No. A7-10

[0323] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.622 (0.6); 7.619 (0.6); 7.617 (0.5); 7.605 (0.9); 7.599 (0.7); 7.519 (0.9); 7.501 (1.2); 7.491 (16.0); 7.478 (1.3); 7.401 (0.6); 7.387 (0.9); 7.385 (1.0); 7.381 (1.3); 7.378 (1.0); 7.373 (0.8); 7.360 (1.2); 7.356 (1.1); 7.350 (1.6); 7.346 (1.3); 7.342 (1.4); 7.336 (1.6); 7.332 (1.9); 7.327 (2.2); 7.317 (1.0); 7.313 (1.1); 7.299 (0.5); 7.295 (0.5); 7.282 (0.8); 7.260 (142.6); 7.240 (0.6); 7.227 (1.8); 7.222 (1.7); 7.218 (1.6); 7.211 (3.8); 7.204 (1.5); 7.200 (1.3); 7.194 (1.1); 6.996 (0.8); 5.724 (6.1); 4.655 (0.9); 3.056 (0.9); 3.052 (0.8); 3.038 (2.2); 3.025 (1.2); 3.021 (1.4); 3.000 (1.0); 2.978 (1.0); 2.959 (0.5); 2.420 (0.6); 2.401 (1.0); 2.389 (1.1); 2.044 (0.6); 1.943 (1.2); 1.935 (1.4); 1.925 (3.3); 1.916 (1.9); 1.908 (2.0); 1.677 (0.7); 1.566 (1.7); 1.259 (0.5); 1.256 (0.6); 0.008 (1.5); 0.000 (54.6); 0.009 (1.7)

Example No. A7-11

[0324] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.792 (2.2); 7.788 (2.3); 7.773 (4.4); 7.769 (4.4); 7.755 (2.4); 7.750 (2.4); 7.520 (0.8); 7.459 (0.5); 7.450 (4.3); 7.442 (3.3); 7.439 (5.5); 7.433 (4.0); 7.430 (2.3); 7.427 (5.5); 7.421 (2.0); 7.416 (3.2); 7.412 (2.4); 7.402 (2.2); 7.400 (2.2); 7.396 (3.1); 7.391 (1.9); 7.382 (1.9); 7.377 (1.7); 7.344 (0.8); 7.336 (4.5); 7.329 (3.7); 7.323 (6.3); 7.320 (3.8); 7.313 (6.4); 7.303 (1.2); 7.299 (0.7); 7.286 (0.5); 7.274 (0.9); 7.273 (0.9); 7.2713 (1.1); 7.2705 (1.2); 7.269 (1.6); 7.267 (2.2); 7.261 (138.8); 7.256 (2.5); 7.255 (2.2); 7.2543 (1.8); 7.2535 (1.6); 7.253 (1.4); 7.252 (1.3); 7.251 (1.2); 7.2503 (1.2); 7.2495 (1.2); 7.242 (4.1); 7.239 (4.1); 7.223 (6.2); 7.220 (6.3); 7.211 (2.8); 7.204 (3.7); 7.199 (10.3); 7.198 (9.1); 7.193 (6.5); 7.188 (8.4); 7.186 (8.1); 7.182 (5.5); 7.176 (7.2); 7.175 (6.5); 7.163 (1.3); 7.133 (2.9); 7.131 (2.7); 7.112 (2.8); 7.108 (3.7); 7.105 (2.9); 7.087 (2.5); 7.084 (2.3); 6.997 (0.8); 5.270 (16.0); 4.317 (2.9); 4.295 (2.2); 4.130 (0.9); 4.113 (0.9); 3.385 (1.4); 3.368 (3.0); 3.354 (2.8); 3.340 (3.0); 3.325 (1.5); 2.421 (1.2); 2.413 (1.7); 2.399 (3.1); 2.385 (2.9); 2.380 (3.5); 2.367 (1.9); 2.358 (1.4); 2.089 (1.0); 2.072 (2.8); 2.062 (2.6); 2.055 (4.6); 2.052 (4.5); 2.044 (6.7); 2.037 (2.7); 2.017 (0.9); 2.006 (2.0); 1.614 (1.0); 1.276 (1.3); 1.259 (3.2); 1.255 (2.0); 1.241 (1.3); 0.008 (1.9); 0.000 (59.2); 0.009 (2.0)

Example No. A7-15

[0325] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.815 (0.8); 7.799 (0.9); 7.794 (1.6); 7.778 (1.6); 7.772 (0.9); 7.756 (0.8); 7.519 (0.8); 7.424 (0.8); 7.408 (1.0); 7.403 (1.0); 7.347 (1.5); 7.340 (1.1); 7.338 (1.0); 7.334 (1.3); 7.328 (1.4); 7.324 (2.2); 7.314 (0.6); 7.306 (0.5); 7.300 (1.2); 7.275 (0.6); 7.269 (1.2); 7.260 (151.3); 7.229 (2.0); 7.220 (1.9); 7.211 (1.7); 6.996 (1.4); 6.990 (0.7); 6.974 (1.2); 6.968 (1.3); 6.953 (0.6); 6.949 (0.7); 6.902 (1.0); 6.896 (0.8); 6.881 (1.1); 6.876 (1.3); 6.870 (1.0); 6.855 (0.9); 6.849 (0.8); 5.298 (16.0); 5.238 (2.3); 4.603 (1.2); 3.429 (0.5); 2.9534 (4.0); 2.9527 (4.1); 2.880 (3.5); 2.879 (3.6); 2.408 (0.7); 2.395 (1.3); 2.380 (1.2); 2.376 (1.5); 2.363 (0.8); 2.169 (0.8); 2.107 (1.4); 1.255 (1.7); 0.008 (1.8); 0.006 (0.6); 0.0054 (0.7); 0.0046 (0.8); 0.000 (57.1); 0.005 (0.7); 0.006 (0.6); 0.007 (0.5); 0.009 (1.7)

Example No. A7-17

[0326] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.543 (3.3); 7.537 (3.7); 7.524 (3.2); 7.519 (4.7); 7.466 (1.0); 7.450 (1.9); 7.445 (1.9); 7.433 (1.2); 7.429 (3.9); 7.424 (1.3); 7.412 (1.8); 7.407 (2.2); 7.391 (1.1); 7.324 (3.8); 7.321 (3.5); 7.319 (3.2); 7.305 (6.1); 7.301 (5.3); 7.261 (179.1); 7.238 (1.4); 7.235 (2.0); 7.220 (4.9); 7.216 (5.1); 7.211 (1.5); 7.202 (5.1); 7.199 (5.1); 7.198 (4.8); 7.194 (4.4); 7.180 (3.6); 7.175 (3.7); 7.162 (1.3); 7.157 (1.1); 7.031 (6.0); 7.011 (8.8); 6.997 (1.3); 6.990 (5.1); 5.395 (16.0); 4.523 (1.9); 4.502 (2.5); 4.476 (2.0); 4.131 (0.6); 4.113 (0.6); 3.231 (1.1); 3.213 (2.3); 3.189 (2.3); 3.171 (1.1); 2.955 (0.9); 2.884 (0.8); 2.883 (0.8); 2.437 (1.4); 2.421 (2.6); 2.408 (2.5); 2.388 (1.4); 2.044 (2.8); 2.015 (3.4); 1.996 (2.1); 1.979 (3.7); 1.961 (1.8); 1.277 (0.9); 1.259 (1.9); 1.255 (1.0); 1.241 (0.8); 0.008 (1.9); 0.000 (67.8); 0.009 (1.8)

Example No. A7-21

[0327] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.603 (2.8); 8.592 (2.7); 7.813 (2.3); 7.794 (4.8); 7.770 (3.1); 7.766 (3.2); 7.752 (4.1); 7.747 (3.9); 7.732 (1.7); 7.728 (1.7); 7.519 (3.0); 7.331 (2.2); 7.328 (2.2); 7.319 (3.0); 7.314 (5.8); 7.309 (5.2); 7.301 (5.8); 7.296 (5.5); 7.291 (6.0); 7.282 (1.6); 7.276 (1.3); 7.274 (1.8); 7.273 (1.7); 7.272 (1.7); 7.271 (2.2); 7.270 (2.3); 7.269 (2.3); 7.268 (2.7); 7.267 (3.3); 7.266 (5.4); 7.265 (6.6); 7.260 (562.6); 7.253 (2.2); 7.210 (3.5); 7.181 (0.8); 7.168 (2.9); 7.162 (4.8); 7.154 (5.4); 7.144 (3.7); 7.127 (0.6); 6.996 (3.1); 5.270 (16.0); 4.308 (2.0); 3.624 (2.0); 2.368 (2.3); 2.349 (2.5); 2.337 (1.5); 2.100 (2.0); 2.082 (3.1); 2.073 (2.0); 2.066 (4.0); 1.555 (9.7); 1.256 (0.6); 0.146 (0.6); 0.008 (5.6); 0.006 (1.8); 0.000 (210.3); 0.009 (5.9); 0.050 (1.4); 0.150 (0.6)

Example No. A7-40

[0328] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.457 (5.7); 8.444 (5.9); 7.469 (5.8); 7.456 (6.5); 7.448 (1.7); 7.439 (1.1); 7.436 (1.3); 7.431 (1.8); 7.311 (1.9); 7.307 (1.6); 7.304 (1.5); 7.293 (2.3); 7.288 (2.7); 7.275 (0.5); 7.261 (87.2); 7.214 (0.5); 7.210 (1.1); 7.196 (2.7); 7.191 (2.5); 7.186 (2.5); 7.180 (4.1); 7.173 (2.1); 7.168 (2.0); 7.162 (1.7); 7.149 (0.6); 5.608 (16.0); 4.575 (0.8); 4.555 (1.1); 4.530 (0.8); 3.609 (0.5); 3.592 (1.1); 3.578 (1.0); 3.565 (1.1); 3.549 (0.6); 2.414 (0.7); 2.401 (1.3); 2.383 (1.3); 2.369 (0.7); 2.360 (0.5); 2.013 (0.6); 1.995 (1.0); 1.979 (1.7); 1.969 (1.0); 1.961 (1.0); 1.605 (0.9); 0.008 (1.0); 0.000 (36.3); 0.009 (1.0)

Example No. A7-61

[0329] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.101 (4.2); 8.099 (4.2); 8.081 (4.8); 8.080 (4.6); 7.728 (3.7); 7.726 (4.3); 7.725 (4.0); 7.709 (4.6); 7.706 (7.7); 7.702 (2.9); 7.686 (6.3); 7.683 (4.9); 7.667 (3.8); 7.663 (3.0); 7.548 (4.2); 7.545 (4.2); 7.529 (6.7); 7.525 (6.5); 7.521 (0.8); 7.509 (2.9); 7.506 (2.7); 7.474 (0.5); 7.465 (4.7); 7.457 (4.5); 7.456 (4.0); 7.450 (5.7); 7.4422 (5.7); 7.4416 (5.4); 7.432 (1.0); 7.366 (0.7); 7.355 (4.3); 7.347 (6.5); 7.343 (3.6); 7.340 (4.2); 7.333 (5.9); 7.332 (5.9); 7.323 (1.1); 7.322 (0.9); 7.271 (1.0); 7.262 (116.8); 7.2584 (1.7); 7.2576 (1.0); 7.257 (0.6); 7.256 (0.5); 7.228 (2.3); 7.218 (15.3); 7.210 (11.0); 7.204 (9.4); 7.195 (13.4); 7.185 (1.2); 6.998 (0.6); 5.429 (16.0); 4.344 (1.9); 4.321 (2.6); 4.296 (2.0); 3.504 (1.3); 3.497 (1.4); 3.481 (3.0); 3.476 (2.4); 3.466 (2.3); 3.459 (2.5); 3.454 (2.9); 3.438 (1.4); 3.431 (1.4); 2.955 (2.5); 2.884 (2.2); 2.882 (2.2); 2.442 (1.0); 2.435 (1.5); 2.427 (1.7); 2.421 (2.7); 2.419 (2.8); 2.413 (1.9); 2.406 (2.6); 2.403 (2.9); 2.389 (1.5); 2.380 (1.2); 2.188 (0.9); 2.175 (1.9); 2.171 (2.5); 2.160 (2.1); 2.154 (4.1); 2.150 (3.8); 2.144 (2.1); 2.136 (2.1); 2.116 (0.6); 1.613 (1.7); 1.255 (0.5); 0.008 (1.5); 0.000 (52.4); 0.009 (1.4)

Example No. A7-62

[0330] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.875 (11.4); 7.871 (12.8); 7.867 (4.6); 7.858 (3.8); 7.855 (4.7); 7.721 (2.8); 7.718 (4.7); 7.715 (2.8); 7.702 (3.6); 7.698 (5.4); 7.695 (3.2); 7.553 (4.9); 7.548 (1.6); 7.533 (6.1); 7.520 (1.2); 7.512 (3.7); 7.417 (4.2); 7.410 (3.1); 7.407 (3.0); 7.404 (3.1); 7.399 (3.5); 7.393 (5.3); 7.385 (0.6); 7.353 (0.5); 7.345 (4.0); 7.340 (2.9); 7.335 (2.8); 7.330 (3.0); 7.328 (3.4); 7.322 (5.7); 7.312 (0.9); 7.261 (146.9); 7.237 (0.6); 7.231 (1.8); 7.218 (6.6); 7.214 (8.5); 7.205 (11.7); 7.196 (6.8); 7.191 (4.6); 7.178 (1.1); 6.997 (0.8); 5.206 (16.0); 4.330 (2.1); 4.307 (3.1); 4.286 (2.3); 3.336 (1.4); 3.321 (3.3); 3.306 (2.6); 3.293 (3.2); 3.277 (1.5); 3.271 (1.4); 2.453 (1.1); 2.447 (1.7); 2.433 (3.1); 2.419 (2.8); 2.414 (3.4); 2.401 (1.8); 2.365 (0.5); 2.137 (1.0); 2.119 (2.7); 2.110 (2.4); 2.102 (4.4); 2.092 (2.6); 2.084 (2.4); 2.065 (0.7); 2.033 (1.9); 1.585 (1.6); 1.256 (1.4); 0.008 (1.6); 0.000 (55.6); 0.009 (1.9)

Example No. A7-63

[0331] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.7094 (15.9); 7.7085 (16.0); 7.519 (0.9); 7.377 (1.1); 7.369 (0.9); 7.367 (0.9); 7.363 (1.5); 7.354 (1.7); 7.343 (1.4); 7.334 (1.3); 7.331 (0.9); 7.327 (1.2); 7.321 (1.9); 7.260 (163.6); 7.211 (3.6); 7.203 (2.0); 7.202 (2.2); 7.197 (1.9); 7.196 (2.0); 7.188 (3.0); 6.996 (0.9); 5.227 (5.2); 4.315 (0.8); 3.316 (0.9); 3.303 (0.8); 3.289 (0.9); 2.426 (0.9); 2.407 (1.0); 2.394 (0.6); 2.103 (0.8); 2.086 (1.3); 2.075 (0.7); 2.068 (0.7); 2.044 (1.0); 1.551 (8.1); 1.259 (0.6); 0.008 (1.8); 0.000 (62.6); 0.009 (1.8)

Example No. A7-81

[0332] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.300 (3.8); 8.281 (4.0); 7.734 (3.8); 7.714 (4.5); 7.633 (1.9); 7.614 (4.0); 7.596 (2.4); 7.528 (2.8); 7.519 (1.9); 7.508 (4.3); 7.503 (4.9); 7.495 (3.6); 7.489 (4.2); 7.485 (3.7); 7.480 (4.6); 7.371 (4.2); 7.366 (3.3); 7.362 (3.1); 7.353 (4.0); 7.348 (5.8); 7.336 (0.7); 7.296 (0.6); 7.260 (239.2); 7.246 (6.2); 7.241 (7.7); 7.232 (10.6); 7.224 (5.5); 7.217 (3.9); 7.210 (1.8); 7.204 (1.2); 7.198 (0.6); 6.996 (1.3); 5.473 (16.0); 4.353 (2.2); 4.329 (3.0); 4.307 (2.3); 3.258 (1.5); 3.240 (3.2); 3.229 (2.6); 3.214 (3.0); 3.197 (1.5); 3.191 (1.5); 2.411 (1.8); 2.395 (3.1); 2.378 (3.2); 2.362 (1.7); 2.120 (0.8); 2.064 (1.0); 2.046 (2.8); 2.036 (3.2); 2.030 (4.6); 2.019 (2.5); 2.011 (2.4); 1.569 (2.7); 1.256 (0.9); 0.008 (2.6); 0.000 (85.5); 0.009 (3.1); 0.050 (0.5)

Example No. A7-603

[0333] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.009 (0.8); 8.006 (0.8); 7.989 (1.7); 7.986 (1.7); 7.969 (0.9); 7.966 (0.9); 7.588 (1.0); 7.584 (0.9); 7.569 (0.6); 7.565 (0.6); 7.481 (1.1); 7.474 (0.6); 7.473 (0.6); 7.467 (0.6); 7.463 (1.5); 7.459 (1.2); 7.344 (0.8); 7.339 (0.6); 7.335 (0.6); 7.328 (0.6); 7.326 (0.7); 7.321 (1.2); 7.261 (36.5); 7.212 (1.1); 7.207 (1.7); 7.198 (2.0); 7.189 (1.3); 7.183 (0.7); 5.767 (5.0); 4.255 (0.5); 3.931 (16.0); 3.381 (0.5); 3.355 (0.5); 2.356 (0.6); 2.341 (0.6); 2.016 (0.8); 0.000 (13.5)

Example No. A7-679

[0334] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.776 (0.7); 8.765 (0.7); 8.741 (6.3); 8.737 (6.7); 8.729 (6.6); 8.725 (6.5); 8.480 (5.2); 8.475 (5.1); 8.459 (5.6); 8.455 (5.2); 7.832 (0.7); 7.813 (0.8); 7.809 (0.8); 7.608 (6.0); 7.596 (5.9); 7.588 (5.8); 7.576 (5.7); 7.520 (1.4); 7.487 (1.2); 7.475 (1.2); 7.468 (1.0); 7.456 (1.1); 7.452 (0.5); 7.443 (4.4); 7.438 (3.9); 7.434 (3.9); 7.429 (3.7); 7.427 (4.0); 7.4203 (5.5); 7.4197 (5.5); 7.410 (0.7); 7.369 (4.3); 7.364 (3.4); 7.362 (3.2); 7.355 (3.7); 7.350 (4.2); 7.346 (5.8); 7.336 (0.7); 7.284 (0.6); 7.261 (248.4); 7.254 (1.7); 7.248 (2.6); 7.235 (7.4); 7.229 (8.7); 7.228 (8.7); 7.220 (14.4); 7.211 (12.4); 7.206 (5.8); 7.192 (1.7); 7.188 (0.9); 6.997 (1.3); 5.470 (16.0); 5.380 (4.5); 4.338 (2.0); 4.313 (2.7); 4.290 (2.1); 3.559 (1.3); 3.553 (1.3); 3.537 (3.0); 3.531 (2.3); 3.521 (2.4); 3.515 (2.5); 3.509 (2.8); 3.493 (1.4); 3.487 (1.3); 2.955 (1.0); 2.931 (0.7); 2.884 (0.9); 2.883 (0.9); 2.460 (0.9); 2.453 (1.5); 2.445 (1.6); 2.436 (2.8); 2.424 (2.5); 2.420 (2.9); 2.407 (1.6); 2.371 (0.5); 2.246 (1.0); 2.229 (2.5); 2.212 (3.9); 2.209 (3.7); 2.201 (2.1); 2.194 (2.1); 2.176 (0.8); 2.049 (2.4); 1.576 (1.8); 1.256 (1.6); 0.008 (3.2); 0.000 (105.1); 0.009 (2.8); 0.050 (0.6)

Example No. A8-15

[0335] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.936 (6.5); 7.932 (7.6); 7.917 (7.5); 7.912 (7.1); 7.521 (0.7); 7.513 (2.1); 7.497 (2.6); 7.492 (3.9); 7.484 (0.8); 7.476 (3.9); 7.470 (2.2); 7.454 (1.9); 7.380 (0.9); 7.376 (0.8); 7.361 (3.7); 7.354 (2.2); 7.350 (5.0); 7.343 (12.8); 7.332 (3.3); 7.324 (9.5); 7.313 (1.7); 7.309 (2.8); 7.303 (2.1); 7.2714 (0.5); 7.2707 (0.6); 7.270 (0.6); 7.269 (0.7); 7.2683 (0.9); 7.2675 (1.1); 7.267 (1.3); 7.266 (1.7); 7.265 (2.4); 7.262 (104.1); 7.255 (0.7); 7.254 (0.6); 6.998 (0.6); 6.875 (2.2); 6.869 (3.3); 6.854 (5.0); 6.848 (6.9); 6.843 (3.1); 6.832 (5.2); 6.827 (5.5); 6.822 (2.9); 6.814 (2.6); 6.806 (1.5); 5.231 (16.0); 4.222 (2.7); 3.466 (1.5); 3.451 (3.4); 3.437 (3.2); 3.423 (3.3); 3.408 (1.6); 2.953 (2.6); 2.883 (2.3); 2.881 (2.4); 2.344 (1.2); 2.337 (2.0); 2.330 (2.1); 2.323 (3.5); 2.309 (3.3); 2.304 (3.9); 2.292 (2.3); 2.284 (1.6); 2.265 (0.5); 2.257 (0.5); 2.102 (1.1); 2.084 (3.1); 2.077 (3.0); 2.065 (4.9); 2.057 (3.3); 2.049 (2.6); 2.043 (3.7); 2.029 (0.8); 1.276 (0.6); 1.258 (1.6); 1.240 (0.6); 0.008 (1.2); 0.000 (40.2); 0.006 (0.5); 0.009 (1.2)

Example No. A9-15

[0336] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.973 (0.5); 7.969 (0.9); 7.952 (0.8); 7.947 (0.5); 7.270 (0.5); 7.269 (0.5); 7.268 (0.5); 7.2674 (0.6); 7.2666 (0.7); 7.266 (0.9); 7.265 (1.1); 7.261 (57.1); 7.255 (0.7); 7.254 (0.6); 7.228 (0.7); 6.916 (0.8); 6.909 (0.9); 6.888 (1.1); 6.881 (1.6); 6.870 (1.1); 6.859 (1.5); 6.854 (1.3); 6.847 (0.8); 6.832 (0.8); 6.827 (0.9); 6.821 (0.7); 6.806 (0.7); 6.800 (0.6); 5.219 (1.4); 4.236 (0.6); 3.886 (16.0); 2.351 (0.8); 2.338 (0.7); 2.333 (0.9); 2.078 (0.9); 1.614 (0.6); 0.008 (0.7); 0.000 (23.7); 0.009 (0.7)

Example No. A9-462

[0337] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm);

Example A9 462

[0338] 1H NMR (400.0 MHz CDCl3): =7.305 (1.0); 7.300 (1.2); 7.286 (1.2); 7.282 (1.3); 7.260 (71.9); 7.217 (0.6); 7.212 (0.6); 7.196 (0.9); 7.193 (0.9); 7.187 (0.7); 7.181 (0.6); 7.177 (0.8); 7.173 (0.7); 7.170 (0.6); 7.166 (1.3); 7.149 (0.5); 7.145 (0.8); 6.883 (2.5); 6.867 (2.8); 6.864 (3.9); 6.846 (3.2); 6.827 (1.5); 4.400 (0.7); 4.039 (1.1); 4.018 (0.9); 4.010 (0.7); 3.997 (1.1); 3.790 (16.0); 3.183 (0.7); 3.170 (0.6); 3.155 (0.7); 2.802 (0.9); 2.783 (1.9); 2.764 (1.1); 2.348 (0.9); 2.335 (0.7); 2.330 (0.9); 2.317 (0.5); 2.296 (0.5); 2.276 (0.9); 2.255 (1.0); 2.235 (0.7); 2.008 (0.7); 1.990 (2.1); 1.981 (0.8); 1.973 (0.7); 0.008 (0.7); 0.000 (25.0); 0.009 (0.8)

Example No. A11-462

[0339] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.724 (7.5); 7.705 (9.1); 7.693 (7.4); 7.673 (10.4); 7.599 (4.7); 7.581 (9.0); 7.563 (5.1); 7.524 (6.0); 7.506 (8.2); 7.486 (3.3); 7.374 (0.6); 7.261 (251.5); 7.249 (7.4); 7.243 (2.9); 7.227 (4.5); 7.222 (4.3); 7.210 (3.1); 7.206 (8.9); 7.201 (3.4); 7.189 (4.2); 7.185 (5.4); 7.168 (2.7); 7.109 (14.3); 6.997 (1.6); 6.968 (7.2); 6.917 (1.3); 6.913 (1.8); 6.901 (11.7); 6.892 (2.2); 6.882 (16.0); 6.872 (2.3); 6.862 (10.4); 6.850 (1.4); 6.846 (1.1); 4.831 (4.0); 4.822 (4.7); 4.808 (6.2); 4.795 (5.1); 4.786 (4.1); 4.033 (8.4); 4.021 (5.8); 4.012 (7.5); 4.003 (5.8); 3.991 (8.7); 3.614 (2.6); 3.609 (2.8); 3.594 (6.3); 3.578 (6.0); 3.563 (6.2); 3.548 (2.7); 3.543 (2.7); 3.137 (1.0); 2.859 (1.4); 2.848 (7.1); 2.831 (15.4); 2.813 (8.0); 2.554 (0.6); 2.542 (0.7); 2.519 (3.4); 2.512 (3.4); 2.505 (6.2); 2.499 (5.4); 2.491 (5.3); 2.484 (6.7); 2.471 (3.9); 2.464 (2.4); 2.446 (0.9); 2.437 (0.8); 2.320 (2.9); 2.303 (6.9); 2.285 (6.1); 2.279 (6.3); 2.260 (6.7); 2.243 (3.2); 2.219 (4.9); 2.211 (5.2); 2.199 (7.8); 2.190 (5.1); 2.181 (4.1); 2.162 (1.2); 2.148 (0.6); 1.333 (1.0); 1.285 (1.5); 1.255 (1.9); 0.008 (2.8); 0.000 (86.1); 0.009 (2.6)

Example No. A14-1

[0340] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.650 (0.6); 8.648 (0.6); 8.630 (0.7); 8.627 (0.6); 7.716 (0.7); 7.698 (0.7); 7.695 (0.7); 7.677 (0.6); 7.471 (0.5); 7.454 (1.2); 7.451 (0.7); 7.268 (0.5); 7.267 (0.7); 7.266 (0.8); 7.265 (1.0); 7.264 (1.3); 7.260 (69.1); 7.257 (1.0); 7.256 (0.7); 7.210 (0.5); 7.114 (0.5); 5.424 (2.8); 1.549 (16.0); 0.008 (0.9); 0.000 (32.2); 0.009 (0.9)

Example No. A14-3

[0341] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.644 (1.6); 8.642 (1.7); 8.624 (1.7); 8.621 (1.7); 8.370 (1.0); 8.353 (1.1); 7.705 (1.8); 7.687 (2.0); 7.684 (2.0); 7.666 (1.7); 7.519 (0.7); 7.320 (1.4); 7.314 (0.7); 7.304 (1.1); 7.298 (5.9); 7.288 (1.7); 7.283 (6.1); 7.277 (1.3); 7.275 (0.6); 7.274 (0.5); 7.2733 (0.6); 7.2726 (0.6); 7.272 (0.6); 7.271 (0.7); 7.270 (0.9); 7.2693 (1.0); 7.2685 (1.3); 7.268 (1.7); 7.267 (1.8); 7.266 (1.9); 7.2653 (2.2); 7.2645 (2.8); 7.261 (121.6); 7.258 (3.4); 7.257 (2.0); 7.2563 (1.3); 7.2555 (1.0); 7.255 (0.7); 7.254 (0.6); 7.253 (0.5); 7.210 (0.8); 6.997 (0.7); 5.160 (5.4); 4.323 (0.8); 3.404 (0.9); 3.392 (0.7); 3.383 (0.7); 3.377 (0.8); 2.372 (0.8); 2.357 (0.8); 2.353 (1.0); 2.102 (0.8); 2.096 (0.7); 2.085 (1.2); 2.082 (1.2); 2.075 (0.7); 2.067 (0.7); 1.558 (16.0); 1.222 (0.6); 0.008 (1.6); 0.006 (0.5); 0.005 (0.6); 0.004 (0.8); 0.002 (2.1); 0.000 (53.7); 0.009 (1.4)

Example No. A14-4

[0342] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.654 (5.2); 8.651 (5.2); 8.633 (5.7); 8.631 (5.5); 8.393 (5.1); 8.390 (5.3); 8.375 (5.8); 8.372 (5.1); 7.714 (5.2); 7.696 (5.2); 7.694 (5.2); 7.675 (4.7); 7.520 (1.0); 7.502 (4.0); 7.498 (4.3); 7.481 (4.4); 7.477 (4.5); 7.384 (3.5); 7.380 (3.4); 7.365 (4.1); 7.361 (3.7); 7.276 (0.5); 7.275 (0.5); 7.274 (0.8); 7.273 (0.9); 7.272 (0.9); 7.2713 (1.1); 7.2705 (1.1); 7.270 (1.3); 7.269 (1.5); 7.268 (1.7); 7.2673 (2.1); 7.2665 (2.5); 7.266 (3.1); 7.261 (163.2); 7.256 (1.2); 7.255 (0.9); 7.2543 (0.7); 7.2535 (0.5); 7.211 (1.1); 7.065 (4.3); 7.045 (7.1); 7.025 (3.6); 6.997 (0.9); 5.479 (16.0); 4.426 (1.3); 4.404 (1.8); 4.378 (1.4); 3.534 (0.8); 3.528 (0.9); 3.512 (2.0); 3.506 (1.5); 3.496 (1.5); 3.489 (1.6); 3.484 (1.9); 3.468 (0.9); 3.461 (0.9); 2.391 (0.6); 2.385 (1.0); 2.368 (1.8); 2.352 (1.9); 2.338 (1.0); 2.158 (0.6); 2.140 (1.6); 2.124 (2.6); 2.120 (2.5); 2.114 (1.4); 2.105 (1.4); 2.044 (1.1); 1.570 (2.5); 1.259 (1.2); 0.069 (0.6); 0.008 (2.1); 0.000 (74.5); 0.009 (2.1); 0.050 (0.5)

Example No. A14-21

[0343] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.624 (2.4); 8.622 (2.7); 8.620 (2.8); 8.617 (2.6); 8.613 (6.0); 8.611 (7.1); 8.607 (2.8); 8.605 (2.4); 8.593 (5.7); 8.590 (5.4); 8.349 (3.7); 8.347 (3.6); 8.331 (3.9); 8.329 (3.7); 7.684 (5.5); 7.666 (5.6); 7.664 (5.4); 7.645 (5.1); 7.498 (1.7); 7.493 (1.7); 7.479 (3.9); 7.474 (3.8); 7.459 (2.8); 7.455 (2.6); 7.367 (2.7); 7.364 (4.5); 7.362 (2.9); 7.348 (2.2); 7.345 (3.3); 7.342 (2.0); 7.273 (0.6); 7.272 (0.6); 7.2713 (0.6); 7.2705 (0.8); 7.270 (0.9); 7.269 (1.2); 7.268 (1.5); 7.264 (62.9); 7.259 (2.8); 7.256 (0.5); 7.250 (2.5); 7.247 (2.5); 7.243 (2.2); 7.240 (2.0); 7.231 (2.0); 7.228 (1.9); 5.288 (16.0); 4.366 (1.3); 4.357 (1.4); 4.344 (1.9); 4.331 (1.6); 4.322 (1.4); 3.778 (0.9); 3.772 (0.9); 3.763 (1.0); 3.757 (2.2); 3.750 (1.5); 3.742 (1.9); 3.734 (1.5); 3.728 (2.0); 3.721 (0.8); 3.712 (0.9); 3.706 (0.9); 2.358 (0.7); 2.352 (1.2); 2.345 (1.2); 2.336 (2.0); 2.332 (1.4); 2.324 (1.8); 2.318 (2.1); 2.307 (1.3); 2.299 (0.8); 2.297 (0.8); 2.168 (0.8); 2.154 (1.3); 2.150 (1.7); 2.143 (1.6); 2.130 (2.5); 2.123 (1.8); 2.115 (1.4); 2.100 (1.9); 1.662 (0.9); 1.255 (0.7); 0.008 (0.8); 0.000 (28.1); 0.009 (0.8)

Example No. A14-22

[0344] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.647 (8.4); 8.644 (9.2); 8.626 (9.8); 8.623 (9.5); 8.615 (5.8); 8.611 (5.8); 8.599 (5.1); 8.595 (5.2); 8.587 (5.2); 8.583 (5.0); 8.377 (8.6); 8.375 (8.6); 8.359 (9.3); 8.357 (9.0); 7.706 (8.9); 7.688 (9.4); 7.686 (10.3); 7.680 (3.6); 7.674 (2.7); 7.668 (9.0); 7.665 (3.1); 7.659 (3.8); 7.655 (2.6); 7.522 (0.8); 7.263 (149.4); 7.258 (1.0); 7.257 (0.8); 7.2563 (0.6); 7.2555 (0.5); 7.213 (1.2); 7.192 (3.4); 7.190 (3.4); 7.180 (3.4); 7.178 (3.4); 7.173 (3.4); 7.171 (3.1); 7.161 (3.1); 7.159 (3.0); 6.999 (0.8); 5.233 (16.0); 4.365 (1.9); 4.355 (2.1); 4.343 (2.8); 4.331 (2.2); 4.321 (2.0); 3.477 (1.4); 3.471 (1.4); 3.462 (1.4); 3.456 (3.4); 3.449 (2.4); 3.440 (2.5); 3.434 (2.5); 3.428 (3.2); 3.412 (1.5); 3.406 (1.4); 2.421 (0.5); 2.414 (1.0); 2.408 (1.6); 2.400 (1.6); 2.394 (2.8); 2.388 (2.2); 2.379 (2.6); 2.375 (3.1); 2.362 (1.7); 2.352 (1.2); 2.178 (1.1); 2.165 (1.8); 2.161 (2.6); 2.153 (2.1); 2.143 (3.9); 2.140 (3.8); 2.133 (2.4); 2.125 (2.2); 2.109 (0.6); 2.105 (0.6); 2.087 (4.1); 2.044 (0.7); 1.614 (3.4); 1.259 (1.0); 0.008 (2.0); 0.007 (0.6); 0.006 (0.6); 0.005 (0.8); 0.004 (1.1); 0.000 (65.9); 0.005 (0.7); 0.006 (0.6); 0.007 (0.5); 0.009 (1.8); 0.050 (0.5)

Example No. A14-61

[0345] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.661 (5.6); 8.659 (5.8); 8.641 (6.0); 8.638 (5.8); 8.402 (1.9); 8.385 (1.9); 7.755 (4.4); 7.753 (4.4); 7.736 (5.2); 7.733 (5.0); 7.722 (6.9); 7.703 (7.4); 7.701 (7.2); 7.683 (6.3); 7.524 (4.1); 7.520 (2.8); 7.504 (5.2); 7.492 (2.9); 7.489 (2.8); 7.473 (6.5); 7.469 (5.5); 7.453 (3.9); 7.450 (3.1); 7.389 (4.5); 7.385 (4.4); 7.369 (6.0); 7.366 (5.7); 7.350 (2.4); 7.347 (2.3); 7.291 (0.6); 7.277 (0.9); 7.275 (1.0); 7.274 (1.3); 7.272 (1.6); 7.2713 (1.7); 7.2705 (1.8); 7.270 (1.9); 7.269 (2.2); 7.268 (2.7); 7.267 (3.2); 7.266 (5.3); 7.261 (341.4); 7.258 (4.1); 7.257 (2.6); 7.256 (1.8); 7.255 (1.4); 7.2543 (1.3); 7.2535 (1.1); 7.253 (1.0); 7.252 (0.8); 7.251 (0.6); 7.211 (2.2); 6.997 (1.9); 5.466 (16.0); 4.390 (2.3); 3.746 (0.6); 3.735 (0.7); 3.723 (0.9); 3.684 (0.7); 3.671 (1.0); 3.637 (1.2); 3.629 (1.0); 3.624 (1.6); 3.615 (1.8); 3.602 (3.1); 3.595 (2.8); 3.590 (2.8); 3.578 (2.7); 3.494 (0.8); 3.477 (1.5); 3.460 (0.8); 2.397 (1.6); 2.381 (3.3); 2.365 (3.0); 2.351 (1.8); 2.316 (0.6); 2.241 (1.0); 2.224 (2.6); 2.206 (4.1); 2.189 (2.1); 2.095 (8.6); 2.044 (2.0); 1.599 (1.5); 1.564 (2.7); 1.380 (0.5); 1.333 (0.8); 1.284 (1.1); 1.277 (0.7); 1.259 (2.1); 1.241 (0.7); 0.940 (1.1); 0.921 (2.5); 0.903 (1.0); 0.008 (4.0); 0.000 (144.4); 0.009 (4.0); 0.050 (0.9)

Example No. A15-1

[0346] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.877 (2.8); 7.871 (1.7); 7.865 (2.6); 7.861 (1.9); 7.854 (3.0); 7.821 (3.7); 7.819 (3.7); 7.801 (3.9); 7.799 (3.7); 7.519 (1.4); 7.462 (2.3); 7.455 (1.9); 7.451 (3.3); 7.444 (3.7); 7.439 (4.3); 7.429 (2.6); 7.425 (2.5); 7.393 (0.6); 7.386 (1.2); 7.374 (5.1); 7.372 (5.3); 7.367 (3.7); 7.362 (4.5); 7.356 (3.7); 7.350 (5.5); 7.337 (0.8); 7.310 (2.1); 7.308 (2.0); 7.292 (3.9); 7.289 (3.7); 7.273 (2.4); 7.270 (2.8); 7.260 (254.1); 7.210 (1.3); 6.996 (1.4); 6.979 (1.5); 6.975 (1.5); 6.959 (2.3); 6.955 (2.3); 6.941 (1.3); 6.936 (1.2); 5.411 (16.0); 4.345 (1.8); 3.428 (0.9); 3.412 (2.1); 3.398 (1.7); 3.384 (2.0); 3.368 (1.0); 3.362 (1.0); 2.444 (1.1); 2.430 (2.0); 2.412 (2.2); 2.399 (1.2); 2.051 (6.0); 2.044 (3.4); 2.033 (2.9); 2.022 (1.7); 2.015 (1.6); 1.565 (1.0); 1.277 (0.7); 1.259 (1.7); 1.256 (1.4); 1.241 (0.7); 0.008 (2.7); 0.000 (96.3); 0.009 (2.7); 0.051 (0.5)

Example No. A15-5

[0347] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.865 (6.2); 7.844 (6.8); 7.828 (3.8); 7.826 (3.8); 7.808 (4.0); 7.806 (3.9); 7.520 (0.7); 7.471 (6.6); 7.466 (7.1); 7.419 (2.4); 7.415 (2.5); 7.400 (3.4); 7.396 (3.3); 7.359 (4.4); 7.353 (4.1); 7.338 (4.1); 7.332 (3.7); 7.312 (2.6); 7.309 (2.7); 7.294 (4.4); 7.291 (4.4); 7.275 (2.4); 7.272 (2.5); 7.269 (0.9); 7.268 (0.9); 7.2674 (1.0); 7.2665 (1.3); 7.266 (1.5); 7.261 (110.6); 7.211 (0.6); 6.997 (0.7); 6.986 (2.3); 6.982 (2.3); 6.968 (2.7); 6.967 (2.8); 6.963 (2.7); 6.962 (2.8); 6.948 (2.0); 6.944 (1.9); 5.360 (16.0); 4.313 (1.7); 4.291 (1.3); 3.432 (0.9); 3.426 (0.9); 3.410 (2.1); 3.405 (1.5); 3.395 (1.7); 3.388 (1.6); 3.382 (2.0); 3.367 (1.0); 3.360 (0.9); 2.455 (0.7); 2.448 (1.1); 2.441 (1.1); 2.435 (2.0); 2.420 (1.7); 2.416 (2.1); 2.403 (1.1); 2.394 (0.8); 2.097 (0.6); 2.078 (1.6); 2.070 (1.5); 2.062 (2.7); 2.059 (2.6); 2.052 (1.6); 2.044 (2.1); 1.594 (0.9); 1.259 (0.5); 0.008 (1.1); 0.000 (42.9); 0.009 (1.2)

Example No. A15-6

[0348] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.900 (5.8); 7.894 (5.8); 7.818 (3.7); 7.815 (3.8); 7.798 (3.9); 7.795 (3.9); 7.520 (0.7); 7.505 (2.9); 7.501 (3.1); 7.486 (3.7); 7.482 (3.6); 7.390 (3.2); 7.369 (9.1); 7.349 (6.4); 7.343 (6.0); 7.337 (2.8); 7.334 (2.8); 7.327 (2.3); 7.321 (2.9); 7.319 (4.8); 7.316 (4.5); 7.300 (2.4); 7.297 (2.3); 7.261 (112.4); 7.211 (0.8); 6.997 (0.6); 6.988 (2.3); 6.984 (2.3); 6.969 (2.9); 6.968 (2.9); 6.965 (2.9); 6.964 (2.8); 6.950 (2.1); 6.945 (2.0); 5.358 (16.0); 4.345 (1.3); 4.324 (1.8); 4.301 (1.3); 3.480 (0.9); 3.473 (0.9); 3.458 (2.2); 3.452 (1.6); 3.443 (1.8); 3.436 (1.7); 3.430 (2.2); 3.414 (1.0); 3.408 (1.0); 2.483 (0.7); 2.476 (1.1); 2.469 (1.1); 2.462 (2.1); 2.448 (1.8); 2.444 (2.3); 2.431 (1.2); 2.422 (0.9); 2.117 (0.9); 2.100 (1.7); 2.092 (1.6); 2.084 (2.8); 2.080 (2.8); 2.073 (1.7); 2.065 (1.6); 2.044 (1.9); 2.035 (3.8); 1.277 (0.5); 1.259 (1.4); 1.256 (1.1); 0.008 (1.2); 0.000 (41.6); 0.009 (1.1)

Example No. A15-7

[0349] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.804 (3.8); 7.802 (4.0); 7.784 (4.0); 7.782 (4.0); 7.521 (0.6); 7.477 (7.6); 7.475 (7.8); 7.456 (16.0); 7.438 (3.1); 7.434 (3.0); 7.369 (6.2); 7.350 (4.7); 7.347 (4.2); 7.328 (3.3); 7.321 (2.5); 7.318 (2.5); 7.302 (4.5); 7.300 (4.2); 7.284 (2.3); 7.281 (2.2); 7.262 (94.1); 7.212 (0.7); 6.998 (0.5); 6.973 (2.0); 6.969 (2.1); 6.954 (2.8); 6.950 (2.7); 6.935 (1.8); 6.931 (1.7); 5.789 (14.1); 4.678 (1.9); 3.084 (0.8); 3.079 (1.0); 3.058 (2.0); 3.051 (1.6); 3.044 (1.7); 3.036 (2.0); 3.017 (1.0); 3.010 (0.9); 2.463 (0.8); 2.456 (1.1); 2.445 (1.6); 2.437 (2.1); 2.425 (2.2); 2.418 (1.7); 2.405 (1.1); 2.399 (0.8); 2.044 (1.1); 1.905 (1.7); 1.899 (1.5); 1.886 (3.1); 1.866 (1.4); 1.259 (0.8); 1.255 (0.6); 0.008 (1.0); 0.000 (35.0); 0.009 (1.0)

Example No. A15-10

[0350] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.850 (0.6); 7.831 (0.6); 7.806 (2.0); 7.803 (1.9); 7.786 (2.0); 7.519 (1.6); 7.495 (16.0); 7.443 (1.0); 7.424 (1.3); 7.398 (0.8); 7.392 (1.3); 7.375 (0.6); 7.373 (0.8); 7.354 (0.5); 7.321 (1.2); 7.300 (1.9); 7.281 (1.5); 7.260 (257.0); 7.210 (1.5); 6.996 (1.4); 6.973 (0.7); 6.957 (1.1); 6.939 (0.6); 5.751 (7.3); 4.655 (1.1); 4.131 (0.7); 4.113 (0.7); 3.066 (1.4); 3.048 (0.9); 3.019 (1.1); 2.999 (1.1); 2.443 (1.2); 2.432 (1.2); 2.044 (3.2); 1.943 (0.8); 1.935 (1.1); 1.926 (2.2); 1.917 (1.6); 1.909 (1.4); 1.900 (1.6); 1.682 (0.5); 1.550 (7.0); 1.277 (0.9); 1.259 (1.9); 1.256 (0.8); 1.241 (0.9); 0.008 (2.9); 0.000 (100.5); 0.009 (2.8); 0.050 (0.7)

Example No. A15-11

[0351] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.805 (5.5); 7.802 (5.8); 7.792 (2.3); 7.785 (6.3); 7.783 (6.1); 7.774 (4.3); 7.769 (4.3); 7.755 (2.3); 7.750 (2.2); 7.519 (1.1); 7.447 (1.2); 7.443 (1.3); 7.434 (1.3); 7.429 (2.7); 7.424 (2.0); 7.422 (1.8); 7.415 (1.9); 7.413 (1.9); 7.408 (3.1); 7.403 (1.8); 7.394 (1.9); 7.390 (5.3); 7.386 (4.1); 7.371 (5.4); 7.367 (5.5); 7.287 (4.1); 7.284 (4.1); 7.274 (0.7); 7.268 (7.5); 7.265 (8.9); 7.261 (179.8); 7.253 (4.0); 7.250 (6.8); 7.247 (3.7); 7.234 (5.7); 7.231 (6.1); 7.215 (2.8); 7.212 (3.0); 7.144 (2.7); 7.142 (2.6); 7.124 (2.5); 7.119 (3.6); 7.116 (2.8); 7.098 (2.3); 7.095 (2.3); 6.996 (1.1); 6.961 (3.4); 6.957 (3.5); 6.942 (4.1); 6.941 (4.3); 6.938 (4.2); 6.937 (4.2); 6.923 (2.9); 6.918 (2.9); 5.276 (16.0); 4.340 (2.0); 4.319 (2.8); 4.296 (2.1); 4.131 (0.6); 4.113 (0.6); 3.412 (1.2); 3.394 (2.9); 3.381 (2.5); 3.367 (2.8); 3.351 (1.3); 2.459 (1.1); 2.452 (1.7); 2.444 (1.7); 2.438 (3.0); 2.424 (2.6); 2.419 (3.4); 2.406 (1.8); 2.397 (1.3); 2.081 (1.0); 2.063 (2.8); 2.055 (2.4); 2.044 (6.5); 2.036 (2.7); 2.028 (2.4); 2.017 (1.4); 2.008 (0.7); 1.590 (2.0); 1.277 (0.8); 1.259 (1.8); 1.256 (1.2); 1.241 (0.8); 0.008 (2.0); 0.000 (70.6); 0.009 (1.9)

Example No. A15-17

[0352] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.790 (3.8); 7.770 (4.1); 7.519 (2.9); 7.478 (3.2); 7.460 (4.4); 7.440 (2.9); 7.419 (1.8); 7.403 (0.8); 7.380 (0.8); 7.313 (2.3); 7.296 (4.4); 7.275 (3.6); 7.260 (497.7); 7.250 (1.1); 7.210 (2.8); 7.041 (4.8); 7.021 (7.7); 7.001 (4.2); 6.996 (4.1); 6.960 (1.8); 6.956 (1.8); 6.940 (2.9); 6.922 (1.5); 5.417 (16.0); 4.474 (2.6); 4.453 (2.0); 4.131 (0.7); 4.113 (0.8); 3.251 (2.4); 3.227 (2.4); 2.465 (2.5); 2.450 (2.6); 2.177 (0.6); 2.170 (2.6); 2.129 (0.7); 2.063 (1.4); 2.044 (3.4); 1.970 (3.5); 1.552 (8.6); 1.277 (1.0); 1.259 (2.5); 1.256 (2.0); 1.241 (0.9); 0.147 (0.6); 0.008 (5.5); 0.000 (188.3); 0.009 (5.2); 0.050 (1.0); 0.150 (0.6)

Example No. A15-40

[0353] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.466 (5.2); 8.454 (5.3); 7.777 (2.3); 7.774 (2.3); 7.757 (2.4); 7.754 (2.3); 7.519 (0.8); 7.474 (4.9); 7.461 (4.8); 7.389 (1.2); 7.385 (1.2); 7.370 (1.7); 7.366 (1.6); 7.290 (1.5); 7.287 (1.5); 7.271 (2.9); 7.268 (3.2); 7.266 (2.1); 7.260 (131.9); 7.252 (1.4); 7.250 (1.2); 7.210 (1.0); 6.996 (0.7); 6.949 (1.0); 6.945 (1.1); 6.930 (1.6); 6.926 (1.5); 6.911 (0.9); 6.906 (0.9); 5.636 (16.0); 4.531 (1.2); 4.509 (0.9); 3.669 (0.6); 3.653 (1.2); 3.639 (1.1); 3.625 (1.1); 3.609 (0.6); 2.455 (0.7); 2.441 (1.4); 2.423 (1.4); 2.409 (0.8); 2.038 (2.7); 1.990 (1.0); 1.974 (1.6); 1.964 (1.1); 1.956 (0.9); 1.580 (0.6); 1.256 (0.6); 0.008 (1.4); 0.000 (51.7); 0.009 (1.4)

Example No. A15-61

[0354] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.107 (3.7); 8.087 (4.2); 7.836 (4.8); 7.833 (4.8); 7.816 (5.1); 7.813 (4.9); 7.741 (3.2); 7.738 (3.7); 7.721 (5.7); 7.719 (5.7); 7.718 (5.4); 7.701 (5.4); 7.698 (4.1); 7.682 (3.1); 7.678 (2.4); 7.563 (3.2); 7.560 (3.2); 7.544 (5.1); 7.541 (4.9); 7.525 (2.2); 7.522 (2.1); 7.408 (3.2); 7.404 (3.2); 7.389 (4.4); 7.385 (4.2); 7.302 (3.2); 7.299 (3.3); 7.294 (0.7); 7.283 (5.7); 7.280 (5.5); 7.261 (159.1); 7.211 (0.7); 6.997 (0.9); 6.987 (2.7); 6.983 (2.8); 6.968 (3.5); 6.963 (3.4); 6.949 (2.4); 6.945 (2.3); 5.432 (16.0); 4.345 (1.6); 4.323 (2.3); 4.301 (1.7); 3.526 (1.1); 3.510 (2.5); 3.495 (2.1); 3.488 (2.1); 3.483 (2.5); 3.466 (1.1); 3.460 (1.1); 2.481 (0.9); 2.473 (1.4); 2.466 (1.4); 2.459 (2.5); 2.445 (2.2); 2.441 (2.8); 2.428 (1.5); 2.418 (1.1); 2.185 (0.8); 2.167 (2.2); 2.157 (1.9); 2.150 (3.4); 2.147 (3.3); 2.140 (2.0); 2.132 (1.8); 2.112 (0.6); 2.044 (1.5); 1.584 (5.1); 1.259 (1.4); 1.256 (1.1); 1.241 (0.5); 0.008 (1.7); 0.000 (56.8); 0.009 (1.6)

Example No. A15-62

[0355] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.885 (3.9); 7.881 (3.5); 7.872 (4.3); 7.868 (15.0); 7.864 (12.9); 7.813 (5.4); 7.811 (5.4); 7.793 (5.9); 7.791 (5.7); 7.736 (3.0); 7.732 (4.2); 7.729 (2.9); 7.716 (3.7); 7.713 (6.3); 7.709 (3.4); 7.568 (4.4); 7.547 (5.3); 7.531 (1.6); 7.527 (3.1); 7.519 (2.9); 7.348 (2.3); 7.344 (2.7); 7.329 (5.8); 7.325 (5.6); 7.310 (4.7); 7.307 (4.7); 7.292 (5.8); 7.289 (5.9); 7.273 (4.1); 7.270 (4.8); 7.260 (466.9); 7.227 (1.0); 7.210 (2.0); 6.996 (2.5); 6.980 (2.6); 6.975 (2.8); 6.961 (3.4); 6.957 (3.3); 6.942 (2.3); 6.938 (2.3); 5.212 (13.5); 4.318 (2.5); 4.149 (1.1); 4.131 (3.3); 4.113 (3.3); 4.095 (1.1); 3.374 (1.6); 3.331 (2.5); 2.491 (1.7); 2.476 (3.3); 2.462 (2.8); 2.457 (3.6); 2.445 (2.0); 2.176 (0.5); 2.129 (2.3); 2.113 (2.5); 2.096 (4.1); 2.085 (2.6); 2.078 (2.3); 2.065 (6.6); 2.044 (16.0); 1.555 (4.8); 1.427 (0.8); 1.413 (0.9); 1.277 (4.6); 1.259 (9.9); 1.241 (4.6); 0.008 (4.7); 0.000 (176.4); 0.009 (6.3); 0.050 (0.8); 0.149 (0.6)

Example No. A15-63

[0356] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 7.815 (0.7); 7.813 (1.1); 7.811 (0.7); 7.794 (0.9); 7.792 (0.8); 7.718 (16.0); 7.288 (2.0); 7.286 (1.8); 7.280 (1.2); 7.273 (1.2); 7.270 (1.1); 7.260 (50.6); 5.234 (2.9); 2.447 (0.5); 2.077 (0.6); 2.074 (0.6); 1.561 (0.8); 0.008 (0.5); 0.000 (19.0); 0.009 (0.6)

Example No. A15-679

[0357] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.757 (5.4); 8.753 (5.7); 8.745 (5.8); 8.741 (5.7); 8.491 (4.5); 8.487 (4.5); 8.471 (5.0); 8.467 (4.6); 7.856 (4.9); 7.854 (4.9); 7.836 (5.2); 7.834 (5.0); 7.623 (5.3); 7.612 (5.2); 7.603 (5.1); 7.591 (5.0); 7.519 (1.7); 7.382 (3.4); 7.378 (3.8); 7.363 (5.6); 7.358 (5.5); 7.306 (4.2); 7.303 (4.2); 7.299 (0.6); 7.294 (0.7); 7.288 (6.0); 7.285 (6.2); 7.280 (0.8); 7.279 (0.8); 7.2782 (0.9); 7.2775 (0.9); 7.277 (1.0); 7.276 (1.0); 7.275 (1.2); 7.2743 (1.3); 7.2735 (1.4); 7.273 (1.5); 7.272 (1.7); 7.271 (1.9); 7.269 (5.5); 7.267 (3.9); 7.266 (6.8); 7.265 (5.9); 7.264 (7.4); 7.260 (299.4); 7.254 (1.3); 7.2533 (1.1); 7.2525 (0.6); 7.211 (1.8); 7.008 (3.6); 7.003 (3.7); 6.996 (1.8); 6.989 (3.8); 6.988 (4.0); 6.985 (3.8); 6.983 (4.0); 6.969 (3.1); 6.965 (3.0); 5.468 (16.0); 4.342 (1.6); 4.317 (2.5); 4.294 (1.8); 3.579 (1.2); 3.564 (2.9); 3.558 (2.1); 3.549 (2.2); 3.542 (2.2); 3.536 (2.6); 3.521 (1.3); 3.514 (1.2); 2.494 (0.9); 2.487 (1.4); 2.480 (1.4); 2.473 (2.4); 2.459 (2.2); 2.454 (2.8); 2.441 (1.6); 2.243 (0.9); 2.225 2.2); 2.208 (3.4); 2.205 (3.4); 2.198 (2.2); 2.190 (1.9); 2.176 (1.0); 2.060 (7.2); 2.044 (1.4); 1.559 (2.0); 1.277 (0.5); 1.259 (1.4); 1.256 (2.0); 1.241 (0.5); 0.008 (3.2); 0.000 (110.6); 0.007 (1.1); 0.009 (3.2); 0.050 (0.7)

Example No. B2-2

[0358] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.801 (5.5); 8.686 (2.8); 8.673 (2.9); 7.535 (5.7); 7.531 (3.7); 7.520 (1.1); 7.487 (4.0); 7.474 (4.0); 7.452 (2.4); 7.447 (3.8); 7.441 (2.6); 7.428 (7.2); 7.425 (7.5); 7.396 (5.2); 7.380 (2.6); 7.372 (2.0); 7.357 (1.6); 7.261 (151.2); 7.209 (0.8); 6.997 (0.9); 5.137 (16.0); 4.283 (1.8); 4.262 (2.6); 4.239 (2.0); 3.344 (1.2); 3.328 (2.6); 3.315 (2.2); 3.301 (2.6); 3.284 (1.3); 2.344 (2.5); 2.326 (2.7); 2.070 (2.2); 2.065 (2.1); 2.045 (3.7); 2.030 (1.9); 1.561 (14.3); 1.259 (0.8); 0.008 (3.0); 0.000 (66.7); 0.008 (3.6)

Example No. B2-4

[0359] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.861 (6.3); 8.705 (3.0); 8.703 (3.0); 8.692 (3.0); 8.690 (3.0); 7.725 (3.0); 7.721 (3.2); 7.706 (3.4); 7.702 (3.4); 7.584 (3.6); 7.580 (3.6); 7.564 (4.4); 7.560 (4.0); 7.513 (3.6); 7.500 (3.5); 7.343 (4.2); 7.324 (6.1); 7.304 (3.3); 7.263 (61.7); 5.433 (16.0); 4.317 (1.1); 4.304 (1.1); 4.296 (1.5); 4.281 (1.2); 4.268 (1.2); 3.422 (0.7); 3.416 (0.8); 3.400 (1.7); 3.395 (1.3); 3.385 (1.3); 3.378 (1.3); 3.372 (1.6); 3.356 (0.8); 3.350 (0.7); 2.358 (0.6); 2.350 (0.9); 2.342 (0.9); 2.336 (1.5); 2.322 (1.4); 2.318 (1.7); 2.304 (0.9); 2.295 (0.6); 2.095 (0.5); 2.077 (1.3); 2.060 (2.3); 2.057 (2.1); 2.050 (1.3); 2.044 (1.9); 2.040 (2.6); 1.259 (0.7); 1.256 (0.9); 0.008 (0.8); 0.000 (27.8); 0.009 (0.8)

Example No. B2-5

[0360] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.854 (6.5); 8.707 (3.0); 8.705 (3.1); 8.694 (3.0); 8.692 (3.1); 7.734 (5.5); 7.713 (6.2); 7.520 (1.3); 7.513 (3.8); 7.499 (8.9); 7.494 (6.6); 7.378 (4.1); 7.373 (3.8); 7.357 (3.7); 7.352 (3.4); 7.271 (0.6); 7.2704 (0.7); 7.2696 (0.7); 7.269 (0.8); 7.268 (1.2); 7.267 (1.4); 7.2664 (1.7); 7.2656 (2.2); 7.265 (2.8); 7.264 (3.7); 7.261 (184.7); 7.2574 (3.3); 7.2566 (2.0); 7.256 (1.4); 7.255 (1.1); 7.254 (0.8); 7.2533 (0.6); 7.2525 (0.7); 7.252 (0.6); 7.251 (0.5); 7.211 (0.9); 6.997 (1.0); 5.339 (16.0); 4.286 (1.2); 4.263 (1.6); 4.237 (1.3); 4.131 (0.6); 4.113 (0.6); 3.414 (0.7); 3.408 (0.8); 3.392 (1.8); 3.377 (1.4); 3.370 (1.4); 3.364 (1.7); 3.348 (0.8); 3.342 (0.8); 2.955 (0.7); 2.885 (0.6); 2.883 (0.6); 2.355 (0.6); 2.348 (0.9); 2.334 (1.6); 2.319 (1.4); 2.315 (1.8); 2.302 (1.0); 2.170 (1.5); 2.097 (0.5); 2.079 (1.4); 2.062 (2.3); 2.059 (2.2); 2.052 (1.4); 2.044 (4.3); 1.563 (6.9); 1.277 (0.9); 1.259 (2.1); 1.241 (1.0); 0.008 (2.4); 0.0064 (0.8); 0.0055 (0.8); 0.005 (1.0); 0.004 (1.2); 0.003 (1.8); 0.002 (3.2); 0.000 (76.8); 0.003 (2.3); 0.004 (1.3); 0.005 (0.9); 0.006 (0.7); 0.007 (0.6); 0.009 (2.2)

Example No. B2-6

[0361] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.936 (6.0); 8.716 (2.7); 8.715 (2.7); 8.703 (2.8); 8.702 (2.8); 8.019 (1.4); 7.815 (4.9); 7.809 (4.9); 7.521 (0.6); 7.509 (3.5); 7.496 (3.4); 7.419 (2.4); 7.418 (2.5); 7.397 (8.2); 7.396 (7.9); 7.381 (6.5); 7.375 (6.0); 7.360 (1.8); 7.354 (2.0); 7.271 (0.5); 7.2704 (0.6); 7.2696 (0.9); 7.269 (0.9); 7.268 (1.0); 7.267 (1.3); 7.2664 (1.7); 7.2655 (2.2); 7.262 (98.1); 7.259 (1.5); 7.258 (0.9); 7.2573 (0.7); 7.2566 (0.5); 7.212 (0.7); 6.998 (0.6); 5.343 (15.9); 4.286 (1.0); 4.265 (1.4); 4.240 (1.1); 4.131 (0.5); 4.113 (0.5); 3.451 (0.7); 3.445 (0.8); 3.429 (1.8); 3.424 (1.3); 3.414 (1.4); 3.407 (1.4); 3.401 (1.7); 3.385 (0.8); 3.379 (0.7); 2.956 (15.3); 2.955 (16.0); 2.884 (14.3); 2.883 (14.3); 2.367 (0.6); 2.361 (0.9); 2.353 (0.9); 2.347 (1.6); 2.332 (1.4); 2.328 (1.7); 2.315 (0.9); 2.306 (0.7); 2.170 (0.5); 2.118 (0.6); 2.100 (1.4); 2.083 (2.3); 2.080 (2.1); 2.073 (1.3); 2.065 (1.2); 2.054 (1.0); 2.044 (2.8); 1.602 (1.4); 1.277 (0.8); 1.259 (1.8); 1.241 (0.7); 0.008 (1.3); 0.004 (0.7); 0.002 (1.8); 0.000 (430.4); 0.003 (1.7); 0.004 (0.6); 0.009 (1.3)

Example No. B2-7

[0362] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.892 (6.1); 8.699 (2.9); 8.686 (2.9); 7.520 (1.0); 7.501 (4.5); 7.488 (11.8); 7.486 (10.1); 7.467 (14.5); 7.385 (6.9); 7.367 (5.1); 7.363 (4.5); 7.345 (3.5); 7.261 (180.3); 7.212 (1.0); 6.997 (0.9); 5.732 (16.0); 4.612 (1.8); 3.094 (0.9); 3.074 (2.0); 3.068 (1.6); 3.060 (1.7); 3.053 (2.0); 3.033 (1.1); 2.955 (2.3); 2.885 (2.0); 2.883 (2.0); 2.339 (1.1); 2.322 (2.0); 2.309 (2.1); 2.302 (1.7); 2.290 (1.1); 2.059 (2.2); 1.934 (1.7); 1.914 (3.1); 1.895 (1.4); 1.583 (3.1); 1.256 (1.8); 0.008 (2.3); 0.000 (74.5); 0.009 (1.9)

Example No. B2-10

[0363] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.882 (0.7); 8.701 (0.6); 7.520 (0.6); 7.506 (16.0); 7.491 (1.2); 7.261 (86.4); 5.693 (6.9); 4.599 (0.7); 3.036 (0.9); 3.014 (0.9); 2.956 (3.9); 2.884 (3.3); 2.883 (3.4); 2.328 (0.9); 2.316 (0.9); 1.948 (0.8); 1.928 (1.4); 1.914 (0.6); 1.577 (0.8); 0.008 (1.1); 0.000 (37.0); 0.009 (1.1)

Example No. B2-11

[0364] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.806 (6.8); 8.680 (3.1); 8.679 (3.2); 8.667 (3.2); 8.666 (3.2); 7.706 (1.4); 7.702 (1.4); 7.687 (2.7); 7.683 (2.8); 7.669 (1.5); 7.664 (1.4); 7.519 (1.7); 7.489 (4.1); 7.476 (4.2); 7.469 (1.0); 7.460 (1.0); 7.455 (1.8); 7.453 (1.3); 7.451 (1.3); 7.449 (1.2); 7.442 (1.4); 7.440 (1.2); 7.437 (1.5); 7.435 (2.0); 7.430 (1.2); 7.421 (1.2); 7.416 (1.1); 7.293 (0.6); 7.285 (0.6); 7.284 (0.6); 7.283 (0.5); 7.282 (0.5); 7.2813 (0.6); 7.2805 (0.6); 7.279 (0.8); 7.278 (0.8); 7.275 (3.0); 7.272 (3.4); 7.270 (2.0); 7.2694 (2.0); 7.2686 (2.2); 7.268 (2.4); 7.267 (2.9); 7.266 (3.5); 7.2653 (4.1); 7.2645 (5.2); 7.264 (6.9); 7.260 (297.5); 7.257 (6.0); 7.256 (6.1); 7.255 (2.9); 7.253 (4.6); 7.251 (0.7); 7.250 (0.6); 7.249 (0.6); 7.237 (1.9); 7.235 (1.8); 7.211 (2.1); 7.170 (1.8); 7.167 (1.7); 7.149 (1.7); 7.145 (2.2); 7.142 (1.8); 7.123 (1.6); 7.121 (1.5); 6.996 (1.7); 5.258 (10.2); 5.256 (10.2); 4.284 (1.4); 4.261 (1.8); 4.237 (1.4); 3.411 (0.8); 3.389 (1.8); 3.376 (1.6); 3.362 (1.8); 3.346 (0.8); 2.351 (0.7); 2.344 (1.0); 2.330 (1.8); 2.315 (1.7); 2.311 (2.0); 2.298 (1.1); 2.092 (0.6); 2.073 (2.6); 2.057 (2.6); 2.054 (2.5); 2.047 (1.5); 2.039 (1.4); 1.557 (16.0); 1.256 (0.5); 0.008 (3.5); 0.000 (131.6); 0.009 (3.6); 0.050 (0.9)

Example No. B2-15

[0365] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.784 (10.1); 8.692 (4.5); 8.679 (4.6); 7.722 (2.2); 7.706 (2.4); 7.700 (4.3); 7.685 (4.4); 7.679 (2.4); 7.663 (2.2); 7.521 (1.0); 7.498 (6.4); 7.485 (6.2); 7.279 (0.5); 7.278 (0.5); 7.277 (0.6); 7.276 (0.6); 7.2753 (0.7); 7.2745 (0.8); 7.274 (0.8); 7.273 (0.9); 7.272 (1.0); 7.2713 (1.1); 7.2705 (1.2); 7.270 (1.4); 7.269 (1.6); 7.268 (1.9); 7.2673 (2.3); 7.2665 (3.0); 7.266 (4.0); 7.262 (165.2); 7.258 (1.7); 7.257 (1.1); 7.256 (0.8); 7.255 (0.6); 7.254 (0.6); 7.024 (1.6); 7.021 (1.7); 7.017 (1.8); 7.015 (1.9); 7.002 (3.1); 6.998 (3.4); 6.996 (3.4); 6.983 (1.6); 6.980 (1.6); 6.976 (1.7); 6.974 (1.7); 6.931 (2.6); 6.925 (2.2); 6.910 (2.9); 6.905 (3.5); 6.899 (2.4); 6.884 (2.6); 6.877 (2.2); 5.219 (15.9); 5.217 (16.0); 4.257 (2.6); 3.394 (1.3); 3.377 (2.9); 3.363 (2.6); 3.350 (2.8); 3.334 (1.3); 2.956 (1.3); 2.884 (1.1); 2.883 (1.2); 2.380 (0.6); 2.363 (1.1); 2.356 (1.7); 2.349 (1.7); 2.341 (3.0); 2.328 (2.7); 2.323 (3.3); 2.310 (1.8); 2.116 (1.1); 2.098 (2.7); 2.081 (4.3); 2.078 (4.2); 2.070 (2.6); 2.062 (2.3); 2.043 (1.1); 1.634 (0.6); 1.259 (0.6); 0.008 (2.0); 0.007 (0.6); 0.006 (0.6); 0.005 (0.7); 0.004 (1.0); 0.003 (1.5); 0.002 (2.5); 0.000 (62.7); 0.005 (0.9); 0.006 (0.7); 0.007 (0.6); 0.009 (1.7)

Example No. B2-17

[0366] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.913 (9.0); 8.682 (4.3); 8.670 (4.3); 7.520 (0.9); 7.494 (1.1); 7.479 (7.0); 7.473 (2.5); 7.466 (6.0); 7.457 (4.3); 7.452 (1.4); 7.440 (2.0); 7.435 (2.4); 7.419 (1.1); 7.262 (154.8); 7.211 (0.9); 7.054 (6.3); 7.034 (9.3); 7.014 (5.4); 6.997 (0.9); 5.376 (16.0); 4.416 (1.8); 4.390 (2.5); 4.370 (1.9); 3.296 (1.1); 3.279 (2.4); 3.265 (2.1); 3.253 (2.4); 3.236 (1.2); 2.955 (0.5); 2.353 (1.5); 2.338 (2.6); 2.321 (2.7); 2.307 (1.5); 2.044 (0.9); 2.037 (0.8); 2.019 (2.2); 2.003 (3.8); 1.993 (2.1); 1.984 (2.0); 1.592 (4.2); 1.256 (0.6); 0.008 (1.9); 0.000 (67.3); 0.009 (2.1)

Example No. B2-21

[0367] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.645 (5.2); 8.643 (3.8); 8.641 (2.8); 8.638 (2.6); 8.633 (5.1); 8.629 (2.9); 8.626 (2.2); 8.578 (6.8); 7.806 (1.6); 7.801 (1.6); 7.787 (3.9); 7.782 (3.9); 7.768 (2.8); 7.763 (2.7); 7.710 (2.7); 7.707 (4.4); 7.704 (2.9); 7.690 (1.9); 7.688 (2.8); 7.685 (1.7); 7.521 (0.6); 7.463 (4.1); 7.450 (3.9); 7.366 (2.1); 7.363 (2.1); 7.354 (2.2); 7.351 (2.2); 7.347 (2.2); 7.344 (2.0); 7.335 (2.0); 7.332 (1.9); 7.262 (102.3); 6.998 (0.6); 5.299 (6.9); 5.249 (16.0); 4.319 (1.2); 4.310 (1.3); 4.297 (1.8); 4.285 (1.4); 4.275 (1.2); 3.706 (0.8); 3.700 (1.0); 3.691 (0.9); 3.684 (2.1); 3.677 (1.8); 3.681 (2.0); 3.662 (1.4); 3.655 (1.9); 3.649 (0.8); 3.640 (0.8); 3.634 (0.8); 2.331 (0.7); 2.324 (1.1); 2.317 (1.1); 2.309 (1.9); 2.304 (1.5); 2.296 (1.7); 2.291 (2.0); 2.279 (1.2); 2.271 (0.8); 2.269 (0.8); 2.123 (0.7); 2.110 (1.2); 2.106 (1.7); 2.098 (1.5); 2.086 (2.4); 2.078 (1.8); 2.070 (1.3); 2.063 (0.8); 2.045 (0.6); 1.631 (0.9); 1.255 (1.1); 0.008 (0.8); 0.000 (31.2); 0.009 (0.9)

Example No. B2-27

[0368] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.845 (13.7); 8.833 (13.9); 8.751 (3.5); 8.629 (2.1); 8.616 (2.1); 7.520 (1.4); 7.428 (3.2); 7.415 (3.1); 7.349 (2.4); 7.337 (4.6); 7.324 (2.3); 7.261 (245.2); 7.257 (1.9); 7.256 (1.5); 7.255 (1.2); 7.254 (1.0); 7.253 (0.7); 7.2524 (0.7); 7.2517 (0.6); 7.251 (0.6); 7.211 (1.4); 6.997 (1.3); 5.437 (16.0); 4.432 (1.3); 3.765 (0.7); 3.749 (1.5); 3.735 (1.4); 3.720 (1.4); 2.955 (4.2); 2.884 (3.6); 2.883 (3.6); 2.358 (0.8); 2.343 (1.6); 2.324 (1.6); 2.312 (1.0); 2.092 (1.2); 2.074 (1.9); 2.068 (1.9); 2.057 (1.1); 2.044 (0.9); 1.570 (8.9); 1.259 (0.6); 1.256 (0.6); 0.008 (2.8); 0.000 (104.9); 0.005 (1.2); 0.006 (1.0); 0.007 (0.9); 0.009 (3.1); 0.050 (0.6)

Example No. B2-40

[0369] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.807 (5.1); 8.668 (2.5); 8.666 (2.5); 8.655 (2.5); 8.653 (2.5); 8.490 (6.3); 8.477 (6.4); 7.520 (0.7); 7.491 (6.3); 7.478 (6.2); 7.466 (3.0); 7.453 (2.9); 7.271 (0.6); 7.270 (0.6); 7.269 (0.7); 7.2684 (0.8); 7.2676 (1.0); 7.267 (1.2); 7.266 (1.6); 7.265 (2.0); 7.264 (2.7); 7.261 (118.6); 7.258 (1.9); 7.257 (1.2); 7.256 (0.8); 7.255 (0.6); 7.211 (1.0); 6.997 (0.7); 5.597 (16.0); 4.485 (0.9); 4.475 (1.0); 4.464 (1.3); 4.451 (1.0); 4.441 (1.0); 3.665 (0.7); 3.649 (1.4); 3.642 (1.0); 3.634 (1.2); 3.627 (1.1); 3.620 (1.3); 3.604 (0.6); 3.598 (0.6); 2.355 (0.8); 2.347 (0.7); 2.340 (1.4); 2.326 (1.1); 2.322 (1.5); 2.309 (0.8); 2.058 (2.1); 2.044 (0.5); 2.020 (1.1); 2.010 (1.0); 2.003 (1.8); 2.000 (1.8); 1.993 (1.1); 1.985 (1.0); 1.577 (1.1); 1.256 (0.6); 0.008 (1.6); 0.005 (0.6); 0.004 (0.8); 0.002 (2.1); 0.000 (52.3); 0.0026 (2.4); 0.0034 (1.5); 0.004 (0.8); 0.005 (0.6); 0.009 (1.5)

Example No. B2-62

[0370] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.729 (7.3); 8.693 (3.4); 8.681 (3.5); 7.880 (1.9); 7.876 (2.8); 7.872 (2.2); 7.860 (2.2); 7.856 (3.2); 7.853 (2.5); 7.780 (3.2); 7.776 (5.8); 7.773 (3.7); 7.764 (2.9); 7.761 (3.6); 7.757 (1.8); 7.745 (3.3); 7.742 (4.2); 7.738 (2.4); 7.603 (3.6); 7.584 (5.8); 7.583 (5.9); 7.565 (2.5); 7.564 (2.5); 7.521 (0.7); 7.500 (4.9); 7.487 (4.7); 7.274 (0.5); 7.273 (0.6); 7.272 (0.6); 7.2713 (0.7); 7.2705 (0.8); 7.270 (0.9); 7.269 (1.0); 7.267 (1.8); 7.266 (2.2); 7.262 (107.5); 7.258 (0.7); 7.257 (0.6); 7.256 (0.5); 7.212 (0.6); 6.998 (0.6); 5.199 (16.0); 4.293 (1.6); 4.284 (1.6); 4.272 (2.3); 4.260 (1.7); 4.248 (1.7); 3.362 (1.0); 3.355 (1.1); 3.340 (2.5); 3.334 (1.8); 3.325 (1.9); 3.318 (1.9); 3.312 (2.4); 3.296 (1.1); 3.290 (1.0); 2.387 (0.8); 2.380 (1.2); 2.373 (1.3); 2.366 (2.2); 2.352 (2.0); 2.347 (2.4); 2.334 (1.3); 2.133 (0.8); 2.115 (1.9); 2.098 (3.1); 2.095 (3.0); 2.087 (1.8); 2.080 (1.6); 2.060 (0.5); 2.050 (2.0); 2.044 (1.7); 1.600 (0.9); 1.277 (0.5); 1.259 (1.3); 0.008 (1.4); 0.005 (0.7); 0.000 (45.0); 0.008 (1.3)

Example No. B2-63

[0371] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.735 (8.8); 8.698 (4.1); 8.697 (4.1); 8.685 (4.2); 8.684 (4.1); 7.750 (7.4); 7.745 (2.8); 7.734 (4.0); 7.729 (13.6); 7.725 (2.4); 7.680 (12.7); 7.675 (3.3); 7.664 (2.7); 7.659 (6.3); 7.520 (1.5); 7.501 (5.0); 7.488 (4.8); 7.291 (0.9); 7.261 (263.5); 7.254 (0.8); 7.227 (0.7); 7.211 (2.2); 6.997 (1.4); 5.219 (16.0); 4.298 (1.6); 4.276 (2.3); 4.254 (1.7); 4.131 (1.0); 4.113 (1.1); 3.352 (1.1); 3.336 (2.5); 3.321 (1.9); 3.314 (2.0); 3.308 (2.3); 3.292 (1.1); 3.286 (1.0); 2.374 (1.3); 2.361 (2.2); 2.346 (2.0); 2.342 (2.5); 2.328 (1.4); 2.170 (0.7); 2.118 (0.8); 2.100 (1.9); 2.084 (3.1); 2.073 (1.8); 2.065 (1.7); 2.044 (5.4); 1.564 (8.2); 1.277 (1.5); 1.259 (3.2); 1.241 (1.6); 0.008 (3.5); 0.000 (111.8); 0.009 (3.3); 0.050 (1.0)

Example No. B2-81

[0372] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.917 (8.6); 8.728 (3.9); 8.715 (4.0); 8.151 (3.5); 8.131 (3.7); 7.763 (3.2); 7.746 (3.7); 7.654 (1.5); 7.635 (3.4); 7.616 (2.2); 7.561 (2.4); 7.541 (3.6); 7.533 (5.6); 7.519 (7.8); 7.286 (0.6); 7.2852 (0.7); 7.2845 (0.6); 7.284 (0.6); 7.282 (0.6); 7.2813 (0.8); 7.2805 (0.8); 7.280 (0.7); 7.279 (0.8); 7.278 (0.8); 7.2773 (0.9); 7.2765 (1.0); 7.276 (1.1); 7.275 (1.3); 7.274 (1.4); 7.2733 (1.5); 7.2725 (1.7); 7.272 (1.8); 7.271 (1.9); 7.270 (2.3); 7.2693 (2.5); 7.2685 (2.9); 7.268 (3.3); 7.267 (3.9); 7.266 (4.6); 7.2653 (5.6); 7.2645 (6.9); 7.264 (9.5); 7.263 (14.3); 7.260 (405.7); 7.257 (5.7); 7.2563 (3.8); 7.2555 (2.8); 7.255 (2.1); 7.254 (1.5); 7.253 (1.3); 7.2523 (1.2); 7.2515 (1.0); 7.251 (0.9); 7.250 (0.9); 7.249 (0.6); 7.228 (0.7); 7.210 (2.6); 6.996 (2.3); 5.456 (16.0); 4.284 (2.3); 4.131 (0.8); 4.113 (0.8); 3.281 (1.3); 3.264 (2.7); 3.249 (2.2); 3.237 (2.6); 3.220 (1.2); 3.214 (1.2); 2.955 (1.3); 2.885 (1.1); 2.883 (1.1); 2.351 (1.4); 2.337 (2.6); 2.319 (2.7); 2.303 (1.5); 2.170 (0.7); 2.077 (3.8); 2.069 (0.9); 2.051 (2.2); 2.044 (5.7); 2.035 (3.8); 2.031 (3.6); 2.024 (2.0); 2.017 (2.0); 1.556 (10.2); 1.277 (1.2); 1.259 (2.8); 1.241 (1.1); 0.010 (0.6); 0.008 (5.1); 0.007 (1.1); 0.006 (1.2); 0.005 (1.3); 0.004 (1.8); 0.003 (3.1); 0.0024 (5.6); 0.0015 (8.5); 0.000 (186.5); 0.004 (3.6); 0.005 (2.6); 0.006 (2.2); 0.007 (1.9); 0.009 (5.2); 0.012 (0.8); 0.050 (1.3)

Example No. B2-462

[0373] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.799 (16.0); 8.788 (7.5); 8.775 (7.3); 7.563 (9.2); 7.550 (8.9); 7.521 (1.0); 7.262 (173.3); 7.236 (1.6); 7.220 (3.2); 7.215 (3.0); 7.203 (2.1); 7.199 (6.4); 7.194 (2.4); 7.182 (2.9); 7.178 (3.9); 7.161 (1.9); 6.998 (1.1); 6.927 (1.0); 6.922 (1.4); 6.911 (8.7); 6.902 (1.7); 6.891 (12.1); 6.881 (1.8); 6.871 (7.7); 6.859 (1.3); 4.537 (3.0); 4.528 (3.3); 4.515 (4.4); 4.503 (3.4); 4.493 (3.1); 4.040 (6.7); 4.028 (4.3); 4.019 (5.6); 4.010 (4.3); 3.998 (6.9); 3.377 (2.0); 3.361 (4.5); 3.355 (3.3); 3.346 (4.1); 3.339 (3.4); 3.332 (4.3); 3.316 (2.0); 3.311 (1.9); 2.834 (5.2); 2.816 (11.1); 2.797 (5.8); 2.435 (0.6); 2.418 (1.5); 2.412 (2.4); 2.404 (2.4); 2.397 (4.5); 2.384 (3.9); 2.378 (4.8); 2.365 (2.7); 2.340 (0.6); 2.331 (0.6); 2.276 (2.1); 2.258 (5.0); 2.246 (3.4); 2.235 (4.8); 2.228 (3.3); 2.216 (4.7); 2.198 (1.8); 2.176 (0.7); 2.161 (1.5); 2.143 (3.7); 2.135 (3.5); 2.122 (5.7); 2.115 (3.7); 2.107 (3.0); 2.087 (0.9); 1.285 (0.6); 1.256 (0.9); 0.008 (1.8); 0.000 (58.4); 0.009 (1.7)

Example No. B2-603

[0374] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.864 (1.9); 8.689 (0.8); 8.677 (0.9); 8.040 (0.8); 8.037 (0.8); 8.020 (0.8); 8.017 (0.8); 7.863 (0.7); 7.860 (0.8); 7.843 (0.9); 7.840 (0.8); 7.618 (0.9); 7.614 (0.9); 7.599 (0.6); 7.595 (0.5); 7.520 (0.8); 7.517 (0.7); 7.501 (1.9); 7.489 (1.1); 7.261 (57.1); 5.749 (4.6); 3.938 (16.0); 2.044 (0.7); 2.019 (0.7); 1.565 (2.2); 0.008 (0.8); 0.000 (25.7); 0.009 (0.7)

Example No. B2-679

[0375] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.790 (13.0); 8.786 (6.4); 8.778 (5.2); 8.774 (5.1); 8.723 (3.8); 8.721 (3.9); 8.710 (3.9); 8.708 (3.9); 8.303 (3.9); 8.299 (3.9); 8.283 (4.2); 8.279 (4.0); 7.648 (4.7); 7.637 (4.6); 7.628 (4.5); 7.616 (4.4); 7.534 (4.9); 7.521 (4.9); 7.274 (0.5); 7.273 (0.5); 7.272 (0.5); 7.269 (1.2); 7.268 (1.3); 7.267 (1.6); 7.266 (1.9); 7.261 (156.5); 7.257 (1.3); 7.256 (0.9); 7.255 (0.7); 7.211 (1.0); 6.997 (0.9); 5.452 (16.0); 4.287 (1.5); 4.274 (1.6); 4.262 (2.2); 4.250 (1.7); 4.241 (1.6); 3.581 (1.0); 3.575 (1.0); 3.559 (2.4); 3.553 (1.8); 3.544 (1.9); 3.537 (1.9); 3.531 (2.3); 3.515 (1.1); 3.509 (1.1); 2.955 (1.1); 2.884 (0.9); 2.883 (0.9); 2.395 (0.7); 2.388 (1.1); 2.381 (1.1); 2.372 (2.3); 2.359 (2.1); 2.354 (2.1); 2.342 (1.3); 2.242 (0.9); 2.225 (1.8); 2.205 (2.9); 2.197 (1.8); 2.190 (1.5); 2.065 (2.2); 1.570 (4.9); 1.256 (1.1); 0.008 (2.0); 0.000 (71.9); 0.009 (1.9)

Example No. B8-462

[0376] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.540 (4.9); 8.536 (5.7); 8.527 (5.2); 8.524 (5.3); 8.475 (5.3); 8.470 (5.9); 8.462 (5.8); 8.458 (5.5); 8.188 (4.6); 8.185 (5.0); 8.169 (5.1); 8.165 (5.1); 7.805 (4.6); 7.801 (5.0); 7.786 (5.0); 7.782 (5.0); 7.688 (3.8); 7.671 (4.5); 7.667 (4.2); 7.657 (3.7); 7.640 (4.4); 7.636 (4.1); 7.610 (1.4); 7.591 (3.0); 7.577 (2.4); 7.573 (2.5); 7.519 (9.9); 7.511 (3.3); 7.499 (4.8); 7.492 (4.7); 7.482 (1.9); 7.360 (1.0); 7.312 (2.7); 7.288 (7.7); 7.276 (11.2); 7.260 (1227.3); 7.229 (1.3); 7.211 (6.2); 7.188 (1.2); 7.175 (5.4); 7.167 (3.1); 7.162 (5.5); 7.155 (6.3); 7.151 (5.5); 7.142 (5.4); 7.135 (2.6); 7.130 (2.8); 7.114 (1.4); 6.996 (6.9); 6.881 (1.4); 6.868 (6.1); 6.848 (9.0); 6.829 (5.3); 4.664 (3.3); 4.460 (4.3); 4.444 (9.7); 4.428 (10.6); 4.412 (13.5); 4.397 (6.6); 4.179 (3.5); 4.157 (3.9); 4.139 (3.5); 3.624 (3.5); 3.286 (4.8); 2.919 (4.6); 2.900 (8.0); 2.882 (4.8); 2.778 (0.9); 2.457 (3.4); 2.223 (4.0); 2.202 (3.6); 2.186 (5.5); 2.166 (6.2); 2.149 (4.6); 2.134 (1.9); 2.100 (3.0); 2.083 (5.0); 2.067 (4.4); 2.052 (3.6); 2.022 (3.2); 1.459 (1.0); 1.332 (5.6); 1.285 (7.8); 1.255 (16.0); 0.880 (2.6); 0.146 (1.5); 0.051 (0.9); 0.008 (14.6); 0.000 (433.0); 0.008 (15.4); 0.050 (2.5); 0.150 (1.7)

Example No. C4-1

[0377] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.546 (6.8); 8.542 (3.9); 8.535 (3.9); 8.532 (7.2); 8.205 (1.0); 8.200 (6.3); 8.195 (2.0); 8.182 (2.2); 8.177 (6.9); 8.172 (0.9); 7.693 (8.4); 7.689 (4.5); 7.682 (4.4); 7.678 (8.1); 7.661 (0.9); 7.655 (5.8); 7.651 (1.9); 7.638 (1.8); 7.633 (5.4); 7.627 (0.7); 5.268 (3.3); 4.054 (0.9); 4.030 (1.0); 3.496 (1.3); 3.474 (2.2); 3.467 (2.3); 3.445 (2.1); 3.438 (2.1); 3.395 (3.6); 3.174 (2.3); 2.711 (1.4); 2.680 (2.5); 2.619 (1.4); 2.592 (1.9); 2.564 (0.8); 2.516 (6.8); 2.512 (14.8); 2.507 (20.6); 2.502 (14.5); 2.498 (6.7); 2.204 (16.0); 0.000 (2.4)

Example No. C4-2

[0378] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.532 (8.6); 8.529 (5.8); 8.521 (5.8); 8.517 (8.7); 7.911 (0.7); 7.907 (2.4); 7.904 (4.9); 7.900 (2.8); 7.899 (3.2); 7.895 (2.8); 7.891 (2.0); 7.888 (2.2); 7.884 (1.0); 7.723 (1.3); 7.720 (1.4); 7.717 (1.3); 7.714 (1.3); 7.702 (1.9); 7.700 (1.9); 7.697 (2.3); 7.694 (2.4); 7.689 (16.0); 7.685 (8.7); 7.678 (8.5); 7.674 (15.5); 7.568 (3.0); 7.548 (4.8); 7.528 (2.1); 7.458 (1.8); 7.453 (3.4); 7.449 (3.2); 7.440 (1.7); 7.434 (10.7); 7.430 (12.6); 7.388 (2.7); 7.386 (2.4); 7.369 (6.2); 7.367 (5.2); 7.351 (4.4); 7.348 (4.8); 7.345 (4.7); 7.341 (7.6); 7.337 (4.1); 7.326 (1.6); 7.322 (2.5); 7.318 (1.2); 5.067 (10.1); 4.078 (2.2); 4.052 (2.3); 3.321 (52.9); 3.269 (0.5); 3.227 (2.1); 3.221 (2.5); 3.197 (4.1); 3.191 (4.2); 3.167 (2.3); 3.161 (2.0); 2.676 (0.6); 2.671 (0.8); 2.666 (0.6); 2.546 (0.6); 2.541 (0.9); 2.524 (2.3); 2.520 (3.5); 2.511 (45.9); 2.507 (98.5); 2.502 (136.9); 2.497 (95.5); 2.493 (41.9); 2.333 (0.6); 2.329 (0.8); 2.324 (0.6); 2.074 (2.3); 2.009 (0.7); 1.999 (0.7); 1.977 (2.0); 1.942 (2.3); 1.920 (0.8); 1.910 (1.0); 1.641 (4.2); 1.606 (2.5); 1.429 (0.6); 1.408 (0.8); 1.398 (1.3); 1.387 (1.0); 1.376 (0.9); 1.366 (1.1); 1.355 (0.7); 0.008 (0.9); 0.000 (25.9); 0.009 (0.7)

Example No. C4-3

[0379] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.528 (4.7); 8.524 (2.5); 8.517 (2.5); 8.513 (4.9); 7.694 (5.4); 7.690 (2.8); 7.683 (2.7); 7.679 (5.3); 7.419 (1.5); 7.413 (0.6); 7.403 (1.0); 7.397 (6.2); 7.393 (1.4); 7.386 (1.3); 7.382 (5.6); 7.376 (0.9); 7.366 (0.6); 7.360 (1.4); 5.058 (2.8); 4.075 (0.6); 4.048 (0.6); 3.324 (13.9); 3.301 (1.0); 3.213 (0.5); 3.207 (0.6); 3.183 (1.0); 3.177 (1.1); 3.153 (0.6); 3.147 (0.5); 2.512 (6.4); 2.507 (13.9); 2.503 (19.4); 2.498 (13.6); 2.493 (6.1); 2.075 (16.0); 1.969 (0.5); 1.935 (0.6); 1.628 (1.2); 1.594 (0.6); 0.000 (3.7)

Example No. C4-12

[0380] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.613 (2.7); 8.611 (3.1); 8.608 (3.3); 8.606 (3.0); 8.601 (2.9); 8.599 (3.3); 8.596 (3.2); 8.594 (2.8); 8.500 (14.1); 8.496 (7.4); 8.489 (7.5); 8.485 (14.6); 7.743 (2.3); 7.738 (2.3); 7.724 (4.4); 7.719 (4.5); 7.704 (2.9); 7.700 (2.8); 7.647 (16.0); 7.643 (8.2); 7.636 (8.2); 7.632 (16.0); 7.402 (2.3); 7.400 (5.4); 7.397 (3.5); 7.390 (3.6); 7.387 (2.5); 7.383 (2.6); 7.380 (5.2); 7.378 (5.7); 7.375 (2.9); 7.371 (3.2); 7.368 (2.1); 7.359 (2.9); 7.356 (2.2); 5.119 (12.1); 4.231 (2.0); 4.203 (2.1); 3.358 (1.7); 3.352 (2.1); 3.323 (24.2); 3.298 (2.5); 2.525 (0.8); 2.520 (1.2); 2.511 (17.9); 2.507 (38.9); 2.502 (54.3); 2.498 (37.7); 2.493 (16.6); 2.021 (0.6); 1.990 (1.5); 1.955 (1.7); 1.934 (0.7); 1.925 (0.7); 1.661 (2.2); 1.625 (2.6); 1.436 (0.7); 1.426 (1.0); 1.415 (0.7); 1.405 (0.7); 1.395 (0.9); 0.000 (10.3)

Example No. C4-13

[0381] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.527 (0.9); 8.516 (0.5); 8.512 (1.0); 7.699 (1.1); 7.695 (0.6); 7.688 (0.6); 7.684 (1.1); 7.169 (0.7); 5.055 (0.6); 3.323 (3.7); 2.512 (1.2); 2.507 (2.5); 2.503 (3.5); 2.498 (2.4); 2.493 (1.1); 2.074 (16.0); 0.000 (1.3)

Example No. C4-21

[0382] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.542 (14.8); 8.538 (8.2); 8.531 (8.3); 8.527 (15.7); 7.934 (3.8); 7.931 (3.7); 7.916 (5.0); 7.912 (4.6); 7.833 (0.6); 7.723 (16.0); 7.719 (8.8); 7.712 (8.5); 7.708 (15.8); 7.672 (1.3); 7.669 (1.5); 7.654 (4.1); 7.650 (4.3); 7.635 (4.7); 7.631 (4.3); 7.624 (3.4); 7.620 (4.7); 7.605 (4.4); 7.601 (5.1); 7.586 (2.2); 7.582 (2.2); 7.578 (5.2); 7.574 (4.8); 7.559 (3.1); 7.556 (3.0); 5.204 (13.9); 4.215 (2.4); 4.188 (2.6); 3.346 (9.9); 3.303 (3.1); 3.297 (3.0); 3.268 (4.4); 3.242 (2.5); 3.215 (0.6); 3.174 (2.8); 2.515 (7.9); 2.511 (17.2); 2.506 (24.0); 2.501 (17.2); 2.497 (7.9); 2.045 (0.7); 2.037 (0.6); 2.012 (2.0); 1.979 (2.2); 1.956 (0.8); 1.947 (1.0); 1.639 (4.2); 1.611 (4.3); 1.483 (0.6); 1.472 (0.6); 1.451 (1.3); 1.440 (0.9); 1.427 (0.9); 1.416 (1.1); 0.000 (3.0)

Example No. C4-30

[0383] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 9.655 (6.2); 8.703 (14.6); 8.699 (8.5); 8.692 (8.5); 8.688 (15.3); 8.629 (1.0); 8.625 (0.6); 8.618 (0.6); 8.614 (1.0); 7.685 (16.0); 7.681 (9.3); 7.674 (8.9); 7.669 (15.6); 7.489 (1.0); 7.485 (0.7); 7.478 (0.7); 7.474 (1.0); 5.920 (0.5); 3.815 (0.8); 3.809 (3.3); 3.773 (2.1); 3.770 (1.4); 3.751 (2.3); 3.330 (15.3); 3.290 (0.6); 3.170 (0.8); 2.839 (8.9); 2.826 (12.3); 2.812 (9.0); 2.526 (0.5); 2.521 (0.8); 2.513 (11.8); 2.508 (25.7); 2.504 (35.9); 2.499 (25.3); 2.494 (11.5); 1.624 (2.4); 1.609 (6.0); 1.595 (8.7); 1.582 (6.8); 1.567 (2.9); 1.399 (1.7); 1.384 (3.4); 1.370 (4.2); 1.355 (2.5); 1.341 (1.0); 0.000 (10.1)

Example No. C4-61

[0384] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.545 (10.0); 8.541 (5.8); 8.534 (5.9); 8.530 (10.4); 7.724 (16.0); 7.721 (13.0); 7.717 (9.2); 7.714 (8.2); 7.710 (14.7); 7.448 (3.2); 7.427 (10.5); 7.413 (8.3); 7.408 (7.5); 7.392 (2.5); 7.387 (2.6); 5.167 (13.2); 4.158 (1.9); 4.132 (2.0); 3.320 (74.0); 3.296 (2.7); 3.289 (1.9); 3.282 (2.0); 3.271 (0.6); 3.254 (3.2); 3.228 (1.9); 3.222 (1.6); 2.525 (1.1); 2.520 (1.7); 2.511 (24.9); 2.507 (54.1); 2.502 (75.3); 2.497 (52.7); 2.493 (23.3); 2.075 (2.1); 2.034 (0.6); 2.025 (0.5); 2.001 (1.6); 1.967 (1.8); 1.943 (0.6); 1.934 (0.8); 1.603 (3.3); 1.569 (2.1); 1.445 (0.5); 1.423 (0.7); 1.413 (1.1); 1.402 (0.7); 1.391 (0.7); 1.381 (0.9); 1.368 (0.5); 0.000 (17.3)

Example No. C4-62

[0385] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.537 (10.4); 8.533 (6.5); 8.526 (6.7); 8.522 (10.9); 8.495 (0.6); 8.480 (0.6); 7.863 (2.5); 7.860 (3.9); 7.856 (2.9); 7.844 (2.8); 7.840 (4.4); 7.837 (3.3); 7.794 (7.2); 7.686 (16.0); 7.682 (10.5); 7.675 (9.1); 7.671 (14.6); 7.664 (5.3); 7.661 (3.9); 7.566 (4.3); 7.547 (6.7); 7.527 (2.9); 5.121 (9.8); 4.083 (2.4); 4.056 (2.4); 3.339 (42.0); 3.248 (2.1); 3.242 (2.5); 3.218 (4.1); 3.212 (4.3); 3.188 (2.4); 3.182 (2.2); 2.528 (0.5); 2.514 (11.1); 2.510 (23.1); 2.505 (31.5); 2.501 (22.7); 2.496 (10.7); 2.006 (0.8); 1.997 (0.7); 1.974 (2.1); 1.940 (2.4); 1.917 (0.9); 1.908 (1.1); 1.644 (4.5); 1.618 (2.8); 1.611 (2.8); 1.438 (0.6); 1.428 (0.5); 1.417 (0.8); 1.407 (1.3); 1.397 (1.1); 1.385 (0.9); 1.375 (1.1); 1.364 (0.8); 0.000 (8.8)

Example No. C4-63

[0386] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.535 (13.4); 8.531 (7.5); 8.524 (7.5); 8.520 (14.2); 7.830 (10.4); 7.826 (3.6); 7.814 (3.8); 7.809 (12.3); 7.696 (16.0); 7.692 (8.9); 7.685 (8.4); 7.681 (15.9); 7.561 (10.9); 7.557 (3.6); 7.545 (3.5); 7.540 (9.2); 5.157 (8.1); 4.077 (2.0); 4.052 (2.1); 3.837 (0.7); 3.831 (1.0); 3.348 (25.0); 3.266 (1.8); 3.260 (2.2); 3.248 (0.8); 3.236 (3.5); 3.231 (3.7); 3.206 (2.1); 3.201 (1.9); 3.173 (1.4); 2.524 (0.7); 2.515 (10.9); 2.511 (23.9); 2.506 (33.1); 2.502 (23.2); 2.497 (10.5); 2.005 (0.6); 1.995 (0.6); 1.972 (1.8); 1.937 (2.1); 1.906 (1.0); 1.637 (4.0); 1.604 (2.3); 1.439 (0.6); 1.407 (1.2); 1.397 (0.9); 1.385 (0.8); 1.375 (1.0); 1.364 (0.6); 0.000 (6.6)

Example No. C4-108

[0387] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.520 (14.9); 8.516 (7.7); 8.509 (8.0); 8.505 (16.0); 7.693 (15.9); 7.689 (8.3); 7.682 (7.9); 7.678 (15.4); 7.503 (2.3); 7.483 (6.3); 7.470 (0.6); 7.463 (5.5); 7.425 (2.5); 7.422 (4.7); 7.419 (3.3); 7.406 (1.7); 7.403 (2.8); 7.400 (1.7); 7.384 (2.3); 7.381 (2.6); 7.378 (2.7); 7.364 (1.6); 7.360 (1.9); 7.358 (2.0); 7.326 (4.1); 5.908 (0.5); 5.124 (6.5); 4.076 (1.7); 4.052 (1.8); 3.328 (14.3); 3.262 (1.7); 3.256 (2.1); 3.232 (3.3); 3.226 (3.4); 3.202 (1.9); 3.196 (1.6); 2.526 (0.8); 2.521 (1.2); 2.513 (17.0); 2.508 (36.7); 2.504 (50.9); 2.499 (35.5); 2.494 (15.7); 2.075 (3.0); 2.014 (0.6); 2.003 (0.5); 1.981 (1.6); 1.946 (1.9); 1.924 (0.7); 1.915 (0.9); 1.646 (3.6); 1.611 (2.0); 1.443 (0.5); 1.421 (0.6); 1.411 (1.1); 1.401 (0.8); 1.389 (0.7); 1.379 (0.9); 1.368 (0.5); 0.000 (8.3)

Example No. C4-112

[0388] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.535 (10.0); 8.531 (6.7); 8.524 (6.6); 8.520 (10.3); 8.286 (0.9); 8.264 (1.1); 8.204 (1.7); 8.198 (13.6); 8.194 (4.2); 8.181 (4.4); 8.176 (14.8); 8.170 (1.5); 8.144 (1.2); 8.122 (0.9); 7.868 (0.5); 7.846 (0.7); 7.700 (16.0); 7.696 (8.8); 7.689 (8.7); 7.685 (15.3); 7.658 (1.8); 7.652 (12.9); 7.647 (4.0); 7.635 (3.9); 7.630 (11.9); 7.624 (1.4); 5.211 (9.8); 4.096 (2.3); 4.071 (2.4); 3.333 (21.7); 3.295 (4.3); 3.288 (4.2); 3.264 (5.0); 3.258 (5.0); 3.234 (2.8); 3.171 (0.6); 2.527 (1.0); 2.522 (1.5); 2.513 (26.6); 2.509 (58.3); 2.504 (81.4); 2.499 (57.3); 2.495 (26.1); 2.011 (0.8); 2.001 (0.7); 1.979 (2.1); 1.944 (2.5); 1.913 (1.1); 1.647 (4.6); 1.620 (3.1); 1.613 (3.1); 1.448 (0.7); 1.437 (0.6); 1.416 (1.4); 1.406 (1.1); 1.394 (0.9); 1.384 (1.2); 1.373 (0.8); 0.008 (0.6); 0.000 (20.6); 0.009 (0.6)

Example No. C5-2

[0389] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 9.089 (3.8); 9.072 (4.0); 8.887 (16.0); 8.479 (4.1); 8.462 (3.9); 7.682 (2.5); 7.679 (2.2); 7.516 (0.6); 7.512 (0.6); 7.508 (1.0); 7.503 (1.8); 7.500 (2.8); 7.495 (2.0); 7.491 (0.9); 7.485 (3.7); 7.484 (3.5); 7.477 (2.0); 7.474 (2.1); 7.469 (2.4); 7.466 (1.9); 7.460 (0.6); 7.457 (0.5); 5.827 (7.1); 5.797 (0.8); 3.329 (104.3); 2.525 (1.0); 2.520 (1.5); 2.511 (19.8); 2.507 (42.1); 2.502 (58.4); 2.498 (41.2); 2.493 (18.6); 0.000 (8.1)

Example No. C5-12

[0390] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 9.091 (3.5); 9.086 (1.5); 9.073 (3.7); 8.894 (16.0); 8.480 (3.7); 8.476 (1.4); 8.468 (1.4); 8.463 (3.6); 7.535 (0.6); 7.519 (0.7); 7.515 (1.1); 7.499 (1.1); 7.495 (0.9); 7.479 (0.9); 7.455 (0.6); 7.450 (0.8); 7.445 (0.7); 7.431 (0.6); 7.426 (0.8); 7.421 (0.7); 7.353 (1.4); 7.334 (1.1); 7.305 (0.5); 7.302 (0.5); 7.298 (0.5); 7.282 (0.9); 7.275 (0.8); 5.842 (6.0); 3.333 (42.0); 2.525 (0.9); 2.520 (1.3); 2.511 (16.5); 2.507 (35.4); 2.502 (49.3); 2.498 (34.5); 2.493 (15.4); 0.000 (7.6)

Example No. C5-13

[0391] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 9.073 (3.4); 9.056 (3.5); 8.882 (16.0); 8.702 (0.7); 8.687 (0.7); 8.471 (3.6); 8.454 (3.4); 7.681 (0.7); 7.666 (0.7); 7.624 (1.7); 7.618 (0.7); 7.610 (1.9); 7.602 (2.0); 7.594 (0.8); 7.588 (1.9); 7.323 (2.3); 7.317 (0.7); 7.306 (0.8); 7.300 (4.2); 7.295 (0.8); 7.284 (0.7); 7.278 (2.0); 5.816 (5.7); 3.770 (0.9); 3.767 (0.8); 3.761 (0.6); 3.380 (0.6); 3.331 (69.5); 2.824 (0.6); 2.525 (0.9); 2.520 (1.3); 2.511 (15.0); 2.507 (31.6); 2.502 (43.4); 2.498 (30.4); 2.493 (13.6); 2.296 (0.5); 2.190 (0.6); 0.000 (5.8).

Example No. C5-30

[0392] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 9.032 (1.5); 9.015 (1.6); 8.912 (6.4); 8.535 (1.7); 8.518 (1.6); 6.250 (2.4); 5.987 (2.7); 3.766 (0.6); 3.757 (16.0); 3.751 (1.7); 3.374 (1.5); 3.358 (0.5); 3.350 (0.7); 3.324 (275.2); 3.301 (7.3); 2.670 (0.6); 2.524 (1.4); 2.519 (2.2); 2.510 (30.2); 2.506 (64.9); 2.501 (90.3); 2.497 (63.7); 2.492 (28.9); 2.328 (0.5); 0.008 (0.6); 0.000 (18.7); 0.009 (0.6)

Example No. C5-37

[0393] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.919 (2.3); 8.902 (2.7); 8.896 (12.3); 8.493 (2.6); 8.476 (2.5); 8.088 (2.1); 5.994 (3.2); 3.766 (16.0); 3.761 (2.3); 3.334 (25.1); 2.511 (5.4); 2.506 (11.7); 2.502 (16.3); 2.497 (11.5); 2.493 (5.2); 2.295 (8.0); 2.287 (1.2); 2.188 (6.6); 0.000 (4.5)

Example No. C5-62

[0394] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 9.087 (3.1); 9.070 (3.2); 8.888 (16.0); 8.806 (0.7); 8.479 (3.4); 8.461 (3.2); 8.055 (2.0); 7.924 (0.8); 7.921 (1.2); 7.917 (0.8); 7.904 (0.9); 7.901 (1.3); 7.898 (0.9); 7.858 (0.9); 7.854 (0.8); 7.841 (0.9); 7.838 (1.2); 7.685 (1.3); 7.666 (2.1); 7.646 (0.9); 5.881 (5.0); 3.327 (117.1); 3.305 (2.9); 2.524 (1.0); 2.520 (1.5); 2.511 (22.4); 2.507 (48.9); 2.502 (68.0); 2.497 (47.3); 2.493 (21.1); 0.000 (1.3)

Example No. C5-111

[0395] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 9.136 (2.8); 9.118 (2.8); 8.881 (16.0); 8.516 (1.1); 8.511 (1.7); 8.506 (1.2); 8.488 (3.0); 8.470 (2.9); 8.300 (0.8); 8.298 (0.9); 8.294 (0.7); 8.292 (0.8); 8.279 (0.8); 8.277 (0.9); 8.274 (0.8); 8.271 (0.9); 7.983 (0.8); 7.962 (1.0); 7.773 (1.2); 7.753 (1.9); 7.734 (1.0); 5.971 (4.5); 5.938 (0.7); 3.377 (0.8); 3.326 (287.5); 3.303 (6.9); 3.277 (1.8); 2.671 (0.6); 2.524 (1.7); 2.520 (2.5); 2.511 (36.5); 2.506 (79.6); 2.502 (110.6); 2.497 (76.7); 2.493 (34.2); 2.457 (0.5); 2.452 (0.6); 2.328 (0.6); 0.000 (13.6)

Example No. C6-2

[0396] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.544 (6.7); 8.540 (3.8); 8.533 (3.9); 8.529 (7.1); 7.692 (7.9); 7.688 (4.3); 7.681 (4.1); 7.677 (7.7); 7.411 (0.8); 7.396 (1.0); 7.392 (1.4); 7.376 (1.7); 7.372 (1.3); 7.356 (1.2); 7.247 (0.9); 7.241 (1.2); 7.232 (2.4); 7.229 (2.2); 7.220 (1.9); 7.218 (1.5); 7.213 (2.2); 7.210 (1.8); 7.207 (2.1); 7.204 (1.8); 7.200 (1.8); 7.182 (1.4); 7.179 (1.3); 7.173 (0.8); 5.137 (3.9); 4.048 (1.0); 4.021 (1.1); 3.434 (0.8); 3.427 (0.9); 3.405 (1.6); 3.398 (1.6); 3.376 (1.2); 3.369 (1.1); 3.342 (43.8); 2.700 (1.4); 2.669 (2.6); 2.618 (1.5); 2.592 (1.8); 2.563 (0.8); 2.558 (0.7); 2.522 (0.6); 2.514 (6.7); 2.509 (14.2); 2.505 (19.7); 2.500 (13.9); 2.496 (6.3); 2.199 (16.0); 0.000 (4.4)

Example No. C6-3

[0397] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.541 (7.6); 8.537 (4.1); 8.530 (4.1); 8.526 (8.0); 7.954 (0.5); 7.932 (0.6); 7.690 (8.9); 7.686 (4.6); 7.679 (4.6); 7.675 (8.9); 7.574 (0.6); 7.552 (0.5); 7.420 (2.3); 7.414 (1.0); 7.404 (1.7); 7.398 (11.2); 7.385 (9.8); 7.379 (1.6); 7.370 (1.0); 7.363 (2.1); 5.116 (3.6); 4.031 (0.9); 4.005 (1.0); 3.416 (2.0); 3.394 (3.0); 3.387 (3.0); 3.366 (2.2); 2.693 (1.3); 2.662 (2.4); 2.609 (1.4); 2.583 (1.8); 2.554 (0.8); 2.515 (5.3); 2.511 (11.7); 2.506 (16.3); 2.502 (11.4); 2.497 (5.1); 2.195 (16.0); 0.000 (4.9)

Example No. C6-5

[0398] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.723 (6.4); 8.719 (3.6); 8.712 (3.7); 8.708 (6.8); 8.576 (16.0); 8.556 (0.7); 8.541 (0.7); 7.874 (5.3); 7.868 (5.6); 7.808 (6.5); 7.804 (3.8); 7.797 (4.4); 7.793 (8.2); 7.773 (3.5); 7.714 (1.2); 7.699 (0.7); 7.646 (2.6); 7.640 (2.5); 7.625 (2.1); 7.620 (2.0); 5.224 (0.6); 4.845 (6.2); 3.815 (0.7); 3.788 (1.6); 3.763 (1.1); 3.588 (1.9); 3.555 (2.8); 3.525 (1.7); 3.498 (1.0); 3.360 (83.1); 3.281 (1.4); 3.250 (1.1); 3.114 (9.2); 2.527 (0.6); 2.522 (1.0); 2.513 (13.0); 2.509 (28.1); 2.504 (38.8); 2.500 (27.1); 2.495 (12.1); 2.181 (1.4); 0.000 (5.5)

Example No. C6-12

[0399] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.546 (5.9); 8.542 (3.5); 8.535 (3.5); 8.531 (6.3); 7.694 (7.3); 7.691 (4.1); 7.684 (3.9); 7.680 (7.2); 7.412 (0.7); 7.397 (1.0); 7.392 (1.3); 7.377 (1.7); 7.373 (1.3); 7.357 (1.1); 7.248 (0.8); 7.242 (1.2); 7.234 (2.4); 7.231 (2.1); 7.228 (1.6); 7.221 (2.0); 7.219 (1.8); 7.215 (2.3); 7.211 (1.9); 7.209 (1.9); 7.205 (1.7); 7.201 (1.6); 7.184 (1.3); 7.180 (1.3); 7.174 (0.8); 5.139 (3.9); 4.050 (1.0); 4.023 (1.1); 3.428 (1.9); 3.406 (3.3); 3.399 (3.4); 3.378 (2.8); 2.701 (1.3); 2.670 (2.6); 2.620 (1.5); 2.591 (1.9); 2.565 (0.8); 2.515 (4.5); 2.511 (9.8); 2.506 (13.6); 2.501 (9.7); 2.497 (4.5); 2.200 (16.0); 0.000 (2.9)

Example No. C6-13

[0400] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.542 (6.3); 8.538 (3.6); 8.531 (3.6); 8.527 (6.6); 7.696 (7.8); 7.692 (4.2); 7.685 (4.1); 7.681 (7.6); 7.427 (2.4); 7.422 (1.0); 7.413 (2.8); 7.405 (3.0); 7.397 (1.2); 7.392 (2.7); 7.195 (3.1); 7.190 (1.0); 7.178 (1.2); 7.173 (5.4); 7.168 (1.1); 7.156 (0.9); 7.151 (2.6); 5.114 (3.8); 4.031 (1.0); 4.005 (1.0); 3.406 (1.0); 3.384 (2.0); 3.377 (2.3); 3.356 (16.3); 2.695 (1.3); 2.663 (2.5); 2.612 (1.5); 2.586 (1.8); 2.557 (0.8); 2.516 (4.0); 2.512 (8.5); 2.507 (11.8); 2.503 (8.3); 2.498 (3.8); 2.196 (16.0); 0.000 (3.0)

Example No. C6-21

[0401] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.547 (2.8); 8.541 (7.0); 8.537 (4.0); 8.535 (3.7); 8.530 (5.7); 8.526 (6.6); 8.508 (2.7); 8.505 (2.7); 7.748 (1.1); 7.744 (1.6); 7.738 (1.1); 7.729 (1.3); 7.724 (1.8); 7.719 (1.2); 7.687 (8.5); 7.683 (4.4); 7.676 (4.3); 7.672 (8.2); 7.386 (1.6); 7.384 (1.6); 7.374 (1.6); 7.372 (1.5); 7.366 (1.5); 7.364 (1.4); 7.354 (1.4); 7.352 (1.4); 5.174 (2.8); 4.028 (0.8); 4.005 (0.8); 3.462 (0.8); 3.455 (0.9); 3.433 (1.6); 3.426 (1.6); 3.404 (1.0); 3.397 (0.9); 3.328 (19.7); 2.707 (1.3); 2.676 (2.4); 2.609 (1.3); 2.583 (1.7); 2.554 (0.7); 2.525 (0.6); 2.520 (0.9); 2.512 (14.4); 2.507 (31.4); 2.502 (44.1); 2.498 (30.7); 2.493 (13.6); 2.202 (16.0); 2.074 (1.2); 0.000 (9.2)

Example No. C6-61

[0402] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.546 (8.1); 8.542 (4.2); 8.535 (4.3); 8.531 (8.4); 7.932 (1.9); 7.929 (1.8); 7.914 (2.6); 7.910 (2.1); 7.706 (9.0); 7.702 (4.7); 7.695 (4.6); 7.691 (8.9); 7.677 (0.8); 7.673 (1.0); 7.658 (2.5); 7.654 (2.3); 7.640 (2.5); 7.635 (2.1); 7.628 (1.8); 7.624 (2.3); 7.609 (2.4); 7.605 (2.5); 7.590 (1.0); 7.586 (0.9); 7.564 (2.1); 7.561 (2.1); 7.545 (1.4); 7.542 (1.3); 5.263 (5.4); 4.173 (1.1); 4.144 (1.2); 3.486 (0.9); 3.478 (1.0); 3.457 (1.8); 3.449 (1.7); 3.428 (1.0); 3.319 (33.9); 3.247 (0.7); 2.727 (1.3); 2.696 (2.2); 2.675 (0.5); 2.670 (0.7); 2.666 (0.5); 2.631 (1.3); 2.605 (1.8); 2.577 (0.8); 2.541 (0.5); 2.524 (1.6); 2.519 (2.3); 2.510 (36.0); 2.506 (78.9); 2.501 (110.5); 2.497 (76.6); 2.492 (33.8); 2.328 (0.7); 2.194 (16.0); 2.074 (3.1); 0.008 (0.8); 0.000 (27.2); 0.009 (0.8)

Example No. C6-62

[0403] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.545 (6.8); 8.541 (3.9); 8.534 (3.9); 8.530 (7.2); 7.683 (8.4); 7.679 (4.4); 7.672 (4.3); 7.668 (8.1); 7.460 (0.8); 7.455 (1.9); 7.451 (1.7); 7.443 (1.9); 7.439 (7.2); 7.435 (6.4); 7.388 (1.2); 7.383 (0.6); 7.368 (3.0); 7.364 (1.1); 7.353 (1.3); 7.348 (4.1); 7.345 (3.6); 7.341 (2.0); 7.330 (0.7); 7.326 (0.9); 5.122 (3.6); 4.036 (1.0); 4.009 (1.0); 3.428 (1.1); 3.406 (1.9); 3.399 (2.0); 3.357 (11.3); 2.704 (1.4); 2.672 (2.5); 2.616 (1.5); 2.587 (1.8); 2.561 (0.8); 2.515 (5.7); 2.510 (12.5); 2.506 (17.4); 2.501 (12.3); 2.496 (5.6); 2.200 (16.0); 0.000 (2.7)

Example No. C6-108

[0404] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.530 (8.3); 8.526 (4.4); 8.519 (4.5); 8.515 (8.7); 7.684 (8.7); 7.681 (4.5); 7.674 (4.4); 7.670 (8.4); 7.506 (1.3); 7.486 (3.5); 7.466 (3.2); 7.432 (2.8); 7.429 (1.9); 7.416 (1.0); 7.413 (1.5); 7.410 (0.9); 7.384 (1.5); 7.382 (1.5); 7.364 (1.1); 7.362 (1.2); 7.326 (2.4); 5.175 (3.0); 4.035 (0.9); 4.011 (0.9); 3.455 (0.9); 3.433 (1.6); 3.426 (1.6); 3.404 (0.9); 3.331 (30.6); 3.310 (1.1); 2.705 (1.3); 2.674 (2.5); 2.619 (1.4); 2.593 (1.8); 2.564 (0.8); 2.522 (0.6); 2.513 (9.6); 2.509 (20.9); 2.504 (29.2); 2.499 (20.4); 2.495 (9.1); 2.202 (16.0); 2.076 (2.5); 0.000 (6.9)

Example No. C6-111

[0405] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.545 (6.2); 8.541 (3.6); 8.534 (3.6); 8.530 (6.7); 8.522 (0.8); 8.507 (0.7); 7.864 (1.3); 7.861 (2.0); 7.857 (1.6); 7.845 (1.5); 7.841 (2.3); 7.838 (1.8); 7.802 (2.2); 7.799 (3.5); 7.795 (2.1); 7.674 (9.9); 7.670 (5.4); 7.663 (4.8); 7.659 (9.6); 7.655 (2.8); 7.651 (1.9); 7.564 (2.3); 7.545 (3.6); 7.525 (1.5); 5.172 (3.5); 4.037 (1.0); 4.011 (1.0); 3.447 (1.0); 3.425 (1.9); 3.418 (1.9); 3.396 (1.5); 3.389 (1.5); 3.341 (16.1); 3.307 (1.7); 3.306 (1.7); 2.705 (1.5); 2.673 (2.8); 2.613 (1.3); 2.609 (1.5); 2.583 (1.9); 2.554 (0.8); 2.522 (0.7); 2.513 (9.9); 2.509 (21.7); 2.504 (30.4); 2.499 (21.4); 2.495 (9.7); 2.202 (16.0); 0.000 (6.1)

Example No. C7-1

[0406] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.556 (12.7); 8.552 (6.9); 8.545 (7.0); 8.541 (13.4); 7.741 (16.0); 7.737 (8.4); 7.730 (8.2); 7.726 (16.0); 7.558 (3.6); 7.555 (3.6); 7.537 (5.3); 7.535 (4.9); 7.473 (2.9); 7.469 (3.8); 7.453 (4.0); 7.452 (5.1); 7.450 (5.4); 7.433 (4.5); 7.429 (3.1); 7.413 (2.9); 7.409 (2.1); 7.307 (3.0); 7.304 (3.1); 7.289 (4.5); 7.285 (4.3); 7.270 (2.1); 7.266 (2.0); 5.274 (13.3); 4.107 (2.3); 4.078 (2.5); 4.046 (2.0); 4.015 (4.2); 3.986 (3.0); 3.809 (3.4); 3.803 (3.6); 3.779 (2.6); 3.772 (2.7); 3.573 (1.9); 3.564 (2.1); 3.544 (3.6); 3.535 (3.4); 3.514 (1.9); 3.506 (1.4); 3.321 (83.7); 3.298 (2.3); 2.671 (0.6); 2.524 (1.6); 2.519 (2.4); 2.511 (35.4); 2.506 (77.0); 2.502 (107.7); 2.497 (75.4); 2.492 (33.4); 2.328 (0.7); 0.008 (1.3); 0.005 (0.6); 0.004 (0.7); 0.002 (1.9); 0.000 (41.8); 0.005 (0.6); 0.009 (1.2)

Example No. C7-2

[0407] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.546 (12.2); 8.542 (6.7); 8.535 (6.7); 8.531 (12.9); 7.859 (0.7); 7.701 (16.0); 7.697 (8.3); 7.690 (8.2); 7.686 (16.0); 7.493 (0.5); 7.490 (0.5); 7.468 (1.8); 7.465 (2.3); 7.463 (2.7); 7.459 (2.7); 7.449 (2.1); 7.444 (5.1); 7.440 (5.7); 7.437 (5.1); 7.434 (6.3); 7.430 (2.8); 7.393 (2.7); 7.392 (2.6); 7.374 (5.9); 7.373 (5.7); 7.355 (3.7); 7.354 (3.7); 7.342 (3.3); 7.338 (5.8); 7.335 (3.2); 7.323 (1.5); 7.319 (2.4); 7.316 (1.2); 5.157 (6.4); 4.018 (2.3); 3.991 (5.8); 3.962 (4.8); 3.817 (3.4); 3.812 (3.5); 3.786 (2.5); 3.781 (2.6); 3.517 (1.7); 3.508 (2.0); 3.487 (3.4); 3.478 (3.3); 3.457 (1.7); 3.449 (1.3); 3.318 (51.4); 3.296 (3.1); 2.675 (0.6); 2.670 (0.8); 2.666 (0.6); 2.524 (1.9); 2.519 (2.9); 2.511 (46.6); 2.506 (102.2); 2.501 (143.6); 2.497 (100.8); 2.492 (44.9); 2.461 (0.6); 2.457 (0.7); 2.452 (0.6); 2.333 (0.6); 2.328 (0.9); 2.324 (0.6); 2.074 (2.6); 0.008 (1.2); 0.000 (41.6); 0.009 (1.1)

Example No. C7-3

[0408] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.546 (13.3); 8.542 (7.0); 8.535 (7.0); 8.531 (13.8); 7.712 (15.1); 7.708 (7.8); 7.701 (7.5); 7.697 (14.5); 7.434 (0.7); 7.430 (5.4); 7.424 (2.0); 7.413 (3.1); 7.408 (16.0); 7.403 (2.7); 7.390 (2.7); 7.385 (14.0); 7.380 (2.8); 7.369 (1.9); 7.363 (4.8); 5.154 (5.9); 4.015 (2.2); 3.988 (5.2); 3.959 (4.1); 3.810 (3.1); 3.806 (3.1); 3.781 (2.3); 3.774 (2.3); 3.511 (1.5); 3.502 (1.8); 3.481 (3.1); 3.472 (3.0); 3.451 (1.5); 3.443 (1.2); 3.337 (52.5); 3.313 (1.4); 2.523 (0.5); 2.515 (7.5); 2.510 (16.2); 2.505 (2.5); 2.501 (15.6); 2.496 (6.8); 2.077 (2.0); 0.000 (4.0)

Example No. C7-5

[0409] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.558 (9.4); 8.555 (5.9); 8.547 (5.9); 8.543 (9.6); 7.733 (15.1); 7.729 (8.8); 7.725 (10.4); 7.720 (13.0); 7.719 (16.0); 7.460 (3.7); 7.439 (11.6); 7.424 (8.8); 7.419 (8.1); 7.403 (2.7); 7.398 (2.9); 5.976 (0.7); 5.252 (13.6); 5.230 (0.7); 4.093 (2.6); 4.064 (2.9); 4.038 (2.4); 4.007 (4.9); 3.978 (3.5); 3.806 (4.0); 3.800 (4.2); 3.775 (3.0); 3.769 (3.1); 3.587 (2.1); 3.579 (2.4); 3.558 (4.0); 3.549 (3.8); 3.529 (2.1); 3.520 (1.6); 3.378 (0.9); 3.353 (2.1); 3.327 (247.7); 3.304 (7.8); 2.676 (0.6); 2.671 (0.8); 2.667 (0.5); 2.541 (0.6); 2.525 (2.0); 2.520 (3.0); 2.511 (43.6); 2.507 (94.7); 2.502 (132.1); 2.498 (92.9); 2.493 (42.1); 2.334 (0.6); 2.329 (0.8); 2.324 (0.6); 0.008 (1.0); 0.000 (34.5); 0.009 (1.0)

Example No. C7-12

[0410] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.547 (11.7); 8.543 (6.6); 8.536 (6.6); 8.532 (12.3); 7.712 (16.0); 7.708 (8.3); 7.701 (8.0); 7.697 (15.6); 7.419 (1.4); 7.404 (1.8); 7.400 (2.5); 7.386 (2.3); 7.383 (2.3); 7.380 (2.6); 7.364 (2.2); 7.257 (1.5); 7.250 (1.7); 7.235 (2.8); 7.228 (6.4); 7.207 (5.1); 7.202 (2.7); 7.197 (2.1); 7.177 (2.3); 7.173 (2.4); 7.167 (1.5); 5.174 (7.1); 4.023 (2.7); 3.993 (5.3); 3.967 (4.2); 3.810 (3.6); 3.785 (2.5); 3.778 (2.6); 3.520 (1.7); 3.510 (2.1); 3.489 (3.5); 3.480 (3.4); 3.459 (1.7); 3.450 (1.4); 3.321 (22.4); 3.248 (0.8); 2.671 (0.6); 2.524 (1.6); 2.520 (2.2); 2.511 (34.6); 2.506 (76.0); 2.502 (106.5); 2.497 (73.9); 2.493 (32.6); 2.329 (0.6); 2.074 (1.5); 0.008 (1.1); 0.000 (37.7); 0.009 (1.0)

Example No. C7-13

[0411] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.543 (3.9); 8.539 (2.1); 8.532 (2.1); 8.528 (4.2); 7.713 (4.5); 7.709 (2.3); 7.703 (2.3); 7.699 (4.4); 7.422 (1.2); 7.409 (1.4); 7.400 (1.5); 7.392 (0.6); 7.387 (1.3); 7.204 (1.6); 7.187 (0.5); 7.182 (2.7); 7.176 (0.5); 7.159 (1.3); 5.148 (1.8); 4.015 (0.6); 3.986 (1.6); 3.958 (1.3); 3.810 (0.9); 3.805 (0.9); 3.780 (0.7); 3.774 (0.7); 3.489 (0.6); 3.468 (0.9); 3.460 (0.9); 3.329 (7.0); 2.512 (3.5); 2.508 (7.6); 2.503 (10.5); 2.499 (7.4); 2.494 (3.3); 2.075 (16.0); 0.000 (2.3)

Example No. C7-22

[0412] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.556 (4.2); 8.552 (4.9); 8.548 (11.4); 8.544 (10.1); 8.540 (5.2); 8.537 (6.4); 8.533 (11.6); 8.512 (4.3); 8.508 (4.3); 8.507 (3.9); 7.749 (1.7); 7.744 (2.5); 7.739 (1.7); 7.729 (2.0); 7.724 (2.8); 7.720 (2.0); 7.712 (13.4); 7.708 (7.0); 7.701 (6.9); 7.697 (13.3); 7.396 (2.4); 7.394 (2.4); 7.384 (2.4); 7.382 (2.4); 7.376 (2.2); 7.374 (2.2); 7.364 (2.2); 7.362 (2.2); 5.214 (4.8); 4.017 (2.0); 3.990 (4.6); 3.961 (3.8); 3.820 (2.9); 3.794 (2.0); 3.788 (2.1); 3.551 (1.5); 3.542 (1.8); 3.521 (3.0); 3.512 (2.9); 3.491 (1.5); 3.483 (1.2); 3.328 (52.2); 3.304 (1.9); 2.526 (0.5); 2.521 (0.8); 2.512 (12.4); 2.508 (2.0); 2.503 (37.7); 2.498 (26.3); 2.494 (11.6); 2.075 (16.0); 0.000 (5.9)

Example No. C7-61

[0413] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.549 (13.4); 8.545 (7.8); 8.538 (8.0); 8.534 (14.0); 7.934 (4.1); 7.931 (4.1); 7.916 (5.2); 7.912 (4.8); 7.727 (16.0); 7.723 (8.9); 7.716 (8.8); 7.712 (15.6); 7.685 (1.4); 7.681 (1.6); 7.666 (4.5); 7.662 (4.6); 7.648 (4.9); 7.643 (4.4); 7.634 (3.6); 7.630 (4.8); 7.615 (4.7); 7.611 (5.5); 7.596 (2.4); 7.589 (5.6); 7.585 (4.9); 7.569 (3.3); 7.566 (3.1); 5.290 (13.8); 4.143 (3.0); 4.114 (3.2); 4.040 (2.4); 4.012 (5.5); 3.983 (3.9); 3.834 (4.9); 3.808 (3.5); 3.802 (3.5); 3.598 (2.4); 3.589 (2.8); 3.569 (4.6); 3.560 (4.3); 3.539 (2.4); 3.531 (1.8); 3.325 (129.9); 3.303 (3.7); 2.541 (0.5); 2.525 (1.8); 2.511 (27.8); 2.507 (57.0); 2.502 (77.3); 2.498 (54.4); 2.493 (24.6); 0.008 (0.9); 0.000 (22.2); 0.009 (0.7)

Example No. C7-62

[0414] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.549 (10.1); 8.546 (6.0); 8.538 (6.0); 8.535 (10.5); 7.874 (2.5); 7.871 (3.9); 7.867 (2.9); 7.855 (2.8); 7.851 (4.4); 7.848 (3.2); 7.801 (4.0); 7.798 (6.5); 7.794 (3.8); 7.698 (16.0); 7.694 (8.5); 7.687 (8.6); 7.683 (15.6); 7.674 (2.2); 7.671 (3.1); 7.667 (2.3); 7.655 (3.0); 7.651 (4.2); 7.648 (2.7); 7.573 (4.2); 7.553 (6.4); 7.534 (2.6); 5.211 (7.0); 4.016 (2.8); 3.987 (5.5); 3.960 (4.2); 3.815 (3.8); 3.790 (2.6); 3.784 (2.8); 3.743 (0.6); 3.541 (1.7); 3.532 (2.2); 3.511 (3.6); 3.502 (3.5); 3.481 (1.7); 3.473 (1.4); 3.324 (8.0); 2.526 (0.8); 2.521 (1.1); 2.512 (17.9); 2.508 (39.6); 2.503 (55.6); 2.498 (38.7); 2.494 (17.2); 2.075 (8.1); 0.008 (0.6); 0.000 (20.2); 0.009 (0.5)

Example No. C7-108

[0415] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.538 (2.9); 8.534 (1.7); 8.527 (1.7); 8.523 (3.0); 7.711 (4.1); 7.707 (2.2); 7.700 (2.1); 7.696 (4.0); 7.515 (0.7); 7.495 (1.8); 7.476 (1.6); 7.432 (1.3); 7.429 (1.0); 7.416 (0.5); 7.412 (0.8); 7.409 (0.5); 7.397 (0.7); 7.394 (0.7); 7.391 (0.8); 7.374 (0.5); 7.371 (0.6); 7.327 (1.2); 5.216 (1.6); 4.029 (0.7); 4.000 (1.7); 3.972 (1.4); 3.819 (1.0); 3.793 (0.8); 3.788 (0.8); 3.550 (0.5); 3.541 (0.6); 3.520 (1.0); 3.512 (1.0); 3.333 (5.5); 2.514 (3.0); 2.510 (6.4); 2.505 (8.8); 2.500 (6.2); 2.496 (2.7); 2.076 (16.0); 0.000 (1.9)

Example No. C7-111

[0416] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.625 (0.5); 8.620 (0.7); 8.616 (0.6); 8.541 (8.4); 8.538 (5.7); 8.530 (5.7); 8.527 (8.8); 8.279 (3.8); 8.274 (6.5); 8.270 (5.2); 8.252 (3.6); 8.249 (4.2); 8.246 (2.6); 8.243 (2.6); 8.231 (3.8); 8.229 (3.9); 8.225 (3.3); 8.223 (3.0); 7.794 (2.5); 7.791 (3.6); 7.788 (2.6); 7.775 (3.6); 7.772 (4.6); 7.769 (3.2); 7.757 (0.5); 7.704 (16.0); 7.700 (8.7); 7.693 (8.3); 7.689 (15.5); 7.664 (4.9); 7.644 (7.3); 7.625 (3.6); 5.313 (6.8); 4.026 (2.9); 3.998 (6.4); 3.970 (5.1); 3.824 (4.3); 3.798 (2.9); 3.792 (3.1); 3.579 (2.0); 3.571 (2.5); 3.549 (4.1); 3.541 (4.0); 3.519 (2.0); 3.511 (1.6); 3.322 (2.3); 2.526 (0.7); 2.521 (1.1); 2.513 (18.7); 2.508 (41.4); 2.503 (58.1); 2.499 (40.5); 2.494 (18.0); 2.453 (0.8); 2.449 (0.7); 2.076 (5.0); 0.008 (0.8); 0.000 (25.1); 0.009 (0.7)

Example No. C7-112

[0417] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.551 (9.8); 8.537 (9.8); 8.330 (1.1); 8.313 (0.6); 8.308 (1.4); 8.210 (14.8); 8.188 (15.8); 8.182 (2.1); 8.179 (2.0); 8.156 (1.1); 7.716 (16.0); 7.712 (9.3); 7.705 (9.3); 7.701 (15.2); 7.654 (14.6); 7.633 (13.4); 5.305 (9.6); 4.025 (5.3); 3.995 (9.6); 3.969 (5.5); 3.823 (6.0); 3.791 (4.3); 3.589 (2.6); 3.581 (3.4); 3.559 (5.5); 3.551 (5.3); 3.530 (2.5); 3.521 (2.2); 3.342 (11.2); 3.173 (0.9); 2.515 (16.2); 2.511 (33.9); 2.506 (46.2); 2.502 (32.7); 2.497 (15.0); 0.000 (5.6)

Example No. C8-2

[0418] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.540 (11.3); 8.536 (6.4); 8.529 (6.5); 8.525 (11.8); 7.689 (15.9); 7.685 (8.3); 7.678 (8.2); 7.674 (16.0); 7.433 (1.4); 7.417 (1.7); 7.412 (2.4); 7.398 (3.2); 7.393 (2.5); 7.378 (2.2); 7.264 (1.6); 7.257 (1.8); 7.243 (6.8); 7.239 (4.7); 7.236 (3.7); 7.223 (4.5); 7.220 (3.4); 7.216 (1.8); 7.204 (2.3); 7.200 (2.2); 7.194 (1.6); 7.179 (2.3); 7.175 (2.5); 7.169 (1.6); 5.212 (2.0); 5.182 (3.3); 5.102 (3.3); 5.072 (2.1); 4.206 (1.0); 4.176 (1.8); 4.144 (1.1); 3.737 (0.8); 3.722 (1.1); 3.710 (1.7); 3.700 (1.0); 3.684 (0.9); 3.326 (22.1); 3.248 (69.9); 3.197 (1.0); 3.194 (0.9); 3.186 (1.1); 3.163 (1.7); 3.156 (1.7); 3.133 (1.0); 3.126 (0.9); 2.946 (2.1); 2.919 (3.5); 2.893 (1.9); 2.526 (0.6); 2.521 (1.0); 2.512 (17.1); 2.508 (37.6); 2.503 (52.7); 2.499 (36.7); 2.494 (16.3); 2.128 (1.0); 2.105 (1.1); 2.075 (1.4); 1.948 (0.9); 1.913 (1.1); 1.771 (1.4); 1.735 (1.0); 1.269 (0.6); 1.248 (1.1); 1.239 (1.1); 1.221 (1.0); 1.210 (1.0); 1.189 (0.5); 0.000 (10.5)

Example No. C8-3

[0419] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.533 (7.5); 8.529 (4.0); 8.522 (4.0); 8.518 (7.9); 7.932 (0.7); 7.910 (0.8); 7.681 (8.8); 7.677 (4.5); 7.670 (4.3); 7.666 (8.6); 7.435 (3.2); 7.430 (1.3); 7.419 (1.8); 7.413 (9.3); 7.408 (1.7); 7.394 (1.6); 7.389 (8.1); 7.384 (1.8); 7.373 (1.1); 7.367 (3.0); 5.197 (1.1); 5.167 (1.6); 5.065 (1.6); 5.034 (1.1); 4.173 (1.0); 4.147 (1.0); 3.709 (0.5); 3.698 (0.8); 3.687 (0.5); 3.324 (11.0); 3.243 (36.8); 3.237 (1.7); 3.170 (0.7); 3.147 (0.9); 3.141 (0.9); 3.117 (0.5); 2.933 (1.0); 2.906 (1.7); 2.880 (0.9); 2.525 (0.7); 2.520 (1.0); 2.512 (15.4); 2.507 (33.6); 2.502 (47.0); 2.498 (32.6); 2.493 (14.4); 2.118 (0.6); 2.086 (0.7); 2.078 (0.5); 2.074 (16.0); 1.896 (0.6); 1.760 (0.7); 1.247 (0.6); 1.236 (0.6); 1.207 (0.5); 0.000 (7.6)

Example No. C8-5

[0420] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.550 (10.0); 8.546 (6.3); 8.538 (6.3); 8.535 (10.4); 7.735 (10.5); 7.729 (10.7); 7.709 (16.0); 7.705 (8.7); 7.698 (8.5); 7.694 (15.6); 7.472 (4.4); 7.451 (12.1); 7.431 (8.9); 7.426 (8.1); 7.410 (3.2); 7.405 (3.3); 5.274 (2.6); 5.242 (6.3); 5.210 (6.4); 5.178 (2.5); 4.294 (1.2); 4.268 (1.3); 4.222 (1.3); 4.197 (1.3); 3.743 (1.0); 3.727 (1.2); 3.717 (1.9); 3.706 (1.2); 3.690 (1.0); 3.680 (0.5); 3.418 (0.5); 3.327 (169.4); 3.287 (1.9); 3.279 (2.0); 3.243 (76.8); 3.226 (1.6); 2.991 (2.4); 2.965 (4.4); 2.939 (2.2); 2.676 (0.5); 2.672 (0.7); 2.667 (0.5); 2.525 (2.0); 2.520 (3.1); 2.512 (43.4); 2.507 (94.5); 2.502 (131.5); 2.498 (91.5); 2.493 (40.8); 2.334 (0.5); 2.329 (0.7); 2.325 (0.5); 2.082 (1.2); 2.074 (1.3); 2.053 (1.3); 1.954 (1.1); 1.922 (1.2); 1.888 (0.6); 1.744 (1.5); 1.711 (1.1); 1.309 (0.6); 1.297 (0.7); 1.278 (1.2); 1.269 (1.3); 1.248 (1.3); 1.237 (1.5); 1.217 (0.6); 0.008 (1.0); 0.000 (33.9); 0.009 (1.0)

Example No. C8-13

[0421] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.533 (8.0); 8.529 (4.3); 8.522 (4.4); 8.518 (8.5); 7.686 (9.9); 7.682 (5.1); 7.675 (5.1); 7.671 (9.9); 7.427 (2.7); 7.422 (1.1); 7.413 (3.1); 7.405 (3.4); 7.397 (1.3); 7.392 (3.0); 7.209 (3.5); 7.204 (1.1); 7.192 (1.2); 7.187 (6.2); 7.181 (1.2); 7.170 (1.0); 7.164 (2.9); 5.199 (1.2); 5.168 (1.8); 5.059 (1.9); 5.029 (1.3); 4.171 (1.2); 4.145 (1.2); 3.713 (0.6); 3.702 (1.0); 3.691 (0.6); 3.675 (0.5); 3.325 (18.0); 3.243 (41.7); 3.236 (1.2); 3.167 (0.5); 3.159 (0.6); 3.136 (1.0); 3.129 (1.0); 3.106 (0.6); 2.918 (1.2); 2.892 (2.0); 2.865 (1.1); 2.525 (0.5); 2.521 (0.8); 2.512 (12.0); 2.507 (26.1); 2.503 (36.4); 2.498 (25.4); 2.493 (11.3); 2.125 (0.6); 2.122 (0.6); 2.098 (0.7); 2.092 (0.7); 2.086 (0.6); 2.075 (16.0); 1.933 (0.5); 1.902 (0.6); 1.899 (0.6); 1.760 (0.8); 1.725 (0.6); 1.242 (0.7); 1.234 (0.7); 1.213 (0.6); 1.203 (0.6); 0.000 (5.7)

Example No. C8-21

[0422] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.542 (14.0); 8.538 (7.2); 8.531 (7.3); 8.527 (14.7); 7.946 (2.8); 7.943 (3.2); 7.942 (2.8); 7.928 (3.4); 7.924 (3.5); 7.701 (15.1); 7.697 (7.9); 7.690 (8.5); 7.686 (16.0); 7.671 (3.4); 7.667 (3.0); 7.652 (4.1); 7.648 (3.7); 7.639 (2.6); 7.635 (4.2); 7.620 (3.3); 7.616 (5.1); 7.609 (4.4); 7.606 (3.1); 7.601 (2.1); 7.597 (1.5); 7.590 (2.1); 7.588 (2.0); 5.327 (2.3); 5.295 (4.0); 5.225 (4.1); 5.193 (2.3); 4.324 (0.9); 4.292 (1.6); 4.260 (1.0); 3.759 (0.7); 3.744 (0.9); 3.733 (1.4); 3.723 (0.9); 3.707 (0.8); 3.323 (56.4); 3.305 (2.0); 3.282 (1.6); 3.274 (1.7); 3.252 (62.4); 3.011 (1.8); 2.985 (3.1); 2.959 (1.6); 2.525 (0.9); 2.520 (1.4); 2.511 (20.8); 2.507 (45.3); 2.502 (63.3); 2.498 (43.8); 2.493 (19.2); 2.090 (0.9); 2.075 (1.9); 1.964 (0.8); 1.929 (0.9); 1.783 (1.2); 1.748 (0.8); 1.318 (0.9); 1.308 (0.9); 1.289 (0.8); 1.279 (0.8); 0.000 (12.2)

Example No. C8-22

[0423] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.710 (0.6); 8.694 (0.6); 8.561 (1.7); 8.557 (1.9); 8.549 (2.0); 8.545 (2.0); 8.538 (4.4); 8.534 (2.5); 8.527 (2.5); 8.523 (4.5); 8.510 (2.0); 8.507 (1.9); 7.762 (0.8); 7.758 (1.1); 7.752 (0.8); 7.743 (0.9); 7.738 (1.2); 7.733 (0.8); 7.687 (1.3); 7.684 (6.1); 7.680 (3.2); 7.673 (3.3); 7.669 (6.0); 7.402 (1.1); 7.400 (1.1); 7.390 (1.1); 7.388 (1.1); 7.383 (1.0); 7.381 (1.0); 7.371 (1.0); 7.369 (1.0); 5.244 (0.6); 5.214 (1.1); 5.141 (1.1); 5.111 (0.6); 4.155 (0.5); 3.700 (0.6); 3.325 (43.4); 3.301 (1.9); 3.272 (3.7); 3.247 (26.7); 3.201 (0.7); 3.194 (0.8); 2.995 (0.8); 2.969 (1.3); 2.942 (0.8); 2.520 (0.6); 2.512 (8.1); 2.507 (17.4); 2.502 (24.2); 2.498 (16.9); 2.493 (7.5); 2.075 (16.0); 1.783 (0.5); 0.000 (5.8)

Example No. C8-61

[0424] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.550 (10.0); 8.546 (6.1); 8.539 (6.1); 8.535 (10.6); 7.718 (16.0); 7.714 (8.5); 7.707 (8.2); 7.703 (15.6); 7.566 (4.0); 7.563 (4.1); 7.546 (6.0); 7.543 (5.5); 7.476 (3.2); 7.472 (4.1); 7.456 (6.1); 7.452 (6.3); 7.437 (4.9); 7.433 (3.3); 7.417 (3.1); 7.413 (2.3); 7.311 (3.2); 7.307 (3.4); 7.292 (4.9); 7.288 (4.7); 7.273 (2.2); 7.270 (2.1); 5.308 (2.9); 5.276 (5.7); 5.225 (5.8); 5.193 (2.9); 4.302 (1.2); 4.270 (1.4); 4.228 (1.2); 3.754 (0.9); 3.738 (1.1); 3.728 (1.8); 3.717 (1.1); 3.701 (1.0); 3.337 (31.9); 3.283 (1.3); 3.275 (1.5); 3.242 (77.1); 3.222 (1.3); 3.215 (1.1); 2.978 (2.3); 2.951 (4.2); 2.925 (2.1); 2.527 (0.7); 2.522 (1.0); 2.513 (14.0); 2.509 (30.6); 2.504 (42.5); 2.500 (29.5); 2.495 (13.0); 2.090 (1.1); 2.075 (1.0); 2.065 (1.2); 1.963 (1.0); 1.928 (1.2); 1.895 (0.5); 1.751 (1.4); 1.715 (1.0); 1.290 (0.6); 1.270 (1.1); 1.261 (1.1); 1.238 (1.1); 1.230 (1.1); 1.209 (0.5); 0.000 (9.3)

Example No. C8-62

[0425] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.541 (9.5); 8.537 (5.9); 8.530 (5.9); 8.526 (10.1); 7.879 (2.5); 7.876 (3.8); 7.872 (2.9); 7.860 (2.8); 7.856 (4.4); 7.853 (3.2); 7.802 (4.1); 7.798 (6.7); 7.795 (4.0); 7.702 (2.1); 7.698 (3.1); 7.695 (2.2); 7.682 (3.2); 7.678 (4.6); 7.673 (16.0); 7.669 (8.2); 7.662 (8.0); 7.658 (15.0); 7.585 (4.1); 7.565 (6.6); 7.546 (2.9); 5.232 (1.8); 5.201 (3.5); 5.147 (3.6); 5.117 (1.9); 4.207 (1.0); 4.185 (1.1); 4.141 (1.1); 4.113 (1.1); 3.726 (0.9); 3.711 (1.1); 3.700 (1.7); 3.689 (1.1); 3.674 (0.9); 3.325 (13.5); 3.251 (70.2); 3.241 (1.0); 3.218 (1.0); 3.211 (1.2); 3.201 (0.6); 3.187 (1.8); 3.181 (1.8); 3.158 (1.1); 3.150 (0.9); 2.975 (2.2); 2.948 (3.5); 2.922 (1.9); 2.526 (0.8); 2.521 (1.2); 2.512 (19.0); 2.508 (41.5); 2.503 (58.0); 2.499 (40.3); 2.494 (17.9); 2.127 (1.1); 2.105 (1.2); 2.075 (4.3); 1.945 (0.9); 1.909 (1.1); 1.877 (0.5); 1.779 (1.5); 1.743 (1.0); 1.284 (0.6); 1.263 (1.1); 1.253 (1.1); 1.235 (1.2); 1.224 (1.0); 0.008 (0.6); 0.000 (18.1)

Example No. C8-108

[0426] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.528 (13.7); 8.524 (7.7); 8.517 (7.8); 8.513 (14.6); 7.683 (16.0); 7.679 (8.7); 7.672 (8.4); 7.668 (15.6); 7.522 (2.7); 7.502 (6.9); 7.482 (6.0); 7.432 (5.2); 7.429 (3.8); 7.412 (3.4); 7.409 (2.5); 7.403 (2.9); 7.399 (3.1); 7.397 (3.1); 7.379 (2.2); 7.376 (2.3); 7.336 (4.9); 5.272 (2.0); 5.242 (2.8); 5.128 (2.9); 5.098 (2.0); 4.173 (2.1); 4.149 (2.3); 3.740 (0.9); 3.725 (1.2); 3.714 (1.8); 3.703 (1.2); 3.687 (1.0); 3.677 (0.5); 3.339 (30.6); 3.298 (0.8); 3.248 (69.3); 3.232 (1.2); 3.225 (1.3); 3.201 (2.1); 3.194 (2.0); 3.171 (1.3); 3.164 (1.0); 2.996 (2.2); 2.969 (3.6); 2.943 (2.0); 2.528 (0.5); 2.524 (0.8); 2.515 (12.0); 2.511 (25.9); 2.506 (36.0); 2.501 (25.4); 2.497 (11.5); 2.136 (1.2); 2.114 (1.3); 1.947 (1.0); 1.913 (1.2); 1.880 (0.6); 1.782 (1.6); 1.746 (1.1); 1.299 (0.5); 1.288 (0.7); 1.267 (1.2); 1.259 (1.2); 1.238 (1.2); 1.228 (1.2); 1.207 (0.5); 0.000 (10.4)

Example No. C8-111

[0427] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.630 (0.8); 8.625 (1.0); 8.621 (0.8); 8.532 (11.1); 8.528 (7.1); 8.520 (7.2); 8.517 (11.6); 8.472 (0.6); 8.469 (0.5); 8.455 (0.5); 8.452 (0.5); 8.449 (0.5); 8.363 (0.6); 8.359 (0.7); 8.356 (0.6); 8.344 (0.6); 8.340 (0.8); 8.337 (0.5); 8.267 (3.6); 8.262 (7.2); 8.258 (6.4); 8.254 (5.2); 8.252 (5.0); 8.246 (1.9); 8.234 (3.8); 8.231 (4.0); 8.228 (3.1); 8.225 (2.6); 7.830 (0.7); 7.810 (3.7); 7.808 (4.1); 7.788 (4.9); 7.677 (16.0); 7.673 (12.8); 7.666 (8.8); 7.662 (15.2); 7.654 (7.4); 7.634 (3.2); 5.350 (2.2); 5.319 (3.5); 5.235 (3.5); 5.205 (2.2); 4.165 (2.5); 4.138 (1.4); 3.746 (0.6); 3.736 (1.0); 3.720 (1.3); 3.710 (2.1); 3.699 (1.3); 3.683 (1.1); 3.673 (0.6); 3.324 (7.4); 3.249 (65.9); 3.231 (2.6); 3.224 (2.5); 3.200 (1.4); 3.193 (1.2); 3.028 (2.4); 3.001 (4.0); 2.975 (2.2); 2.513 (22.5); 2.508 (47.2); 2.504 (64.6); 2.499 (45.8); 2.494 (21.2); 2.141 (1.4); 2.116 (1.5); 2.076 (4.5); 1.951 (1.1); 1.916 (1.4); 1.883 (0.6); 1.789 (1.8); 1.753 (1.2); 1.306 (0.6); 1.295 (0.7); 1.274 (1.4); 1.265 (1.3); 1.246 (1.3); 1.235 (1.4); 1.215 (0.6); 0.008 (0.6); 0.000 (15.6); 0.009 (0.5)

Example No. C8-112

[0428] .sup.1H-NMR (400 MHz d.sub.6-DMSO , ppm); 8.540 (8.2); 8.526 (8.3); 8.339 (2.5); 8.334 (0.9); 8.322 (1.1); 8.316 (3.5); 8.214 (14.7); 8.192 (16.0); 8.184 (4.6); 8.179 (1.3); 8.167 (1.0); 8.162 (2.6); 7.687 (14.5); 7.683 (8.7); 7.676 (8.9); 7.672 (14.2); 7.659 (13.5); 7.637 (12.4); 7.602 (1.2); 7.580 (1.1); 5.355 (2.8); 5.324 (3.9); 5.209 (4.0); 5.179 (2.8); 4.637 (0.8); 4.180 (2.9); 3.734 (1.2); 3.718 (1.6); 3.707 (2.3); 3.696 (1.5); 3.681 (1.3); 3.421 (0.8); 3.329 (26.2); 3.273 (1.9); 3.246 (72.0); 3.227 (3.1); 3.220 (3.0); 3.197 (1.9); 3.190 (1.4); 3.023 (2.6); 2.997 (4.4); 2.971 (2.3); 2.673 (0.6); 2.513 (34.6); 2.508 (70.5); 2.504 (95.3); 2.499 (67.1); 2.495 (30.9); 2.459 (0.5); 2.331 (0.6); 2.127 (1.6); 2.105 (1.7); 1.940 (1.3); 1.905 (1.6); 1.873 (0.8); 1.781 (2.1); 1.745 (1.4); 1.302 (0.6); 1.290 (0.8); 1.270 (1.5); 1.262 (1.5); 1.232 (1.6); 1.210 (0.7); 1.199 (0.5); 0.008 (0.8); 0.000 (20.5); 0.009 (0.7)

Example No. D1-462

[0429] .sup.1H-NMR (400 MHz CDCl.sub.3 , ppm); 8.787 (8.0); 8.784 (8.3); 8.774 (8.5); 8.772 (8.3); 8.055 (7.6); 8.052 (7.9); 8.034 (8.5); 8.032 (8.4); 7.543 (5.7); 7.541 (6.0); 7.530 (6.1); 7.529 (6.3); 7.521 (7.6); 7.510 (5.5); 7.508 (5.6); 7.375 (1.1); 7.312 (3.0); 7.292 (2.0); 7.262 (313.9); 7.234 (5.4); 7.218 (7.0); 7.213 (6.7); 7.201 (4.5); 7.197 (10.4); 7.192 (5.0); 7.180 (5.5); 7.176 (6.8); 7.159 (3.8); 7.141 (1.1); 6.998 (2.0); 6.914 (1.3); 6.909 (1.9); 6.898 (11.6); 6.889 (2.8); 6.878 (16.0); 6.867 (3.3); 6.858 (10.8); 6.846 (2.0); 4.803 (4.4); 4.795 (5.2); 4.781 (6.8); 4.768 (5.7); 4.758 (4.9); 4.041 (9.2); 4.029 (6.4); 4.020 (8.4); 4.010 (6.6); 3.999 (10.1); 3.541 (2.9); 3.525 (6.6); 3.519 (4.7); 3.510 (6.6); 3.502 (5.0); 3.495 (6.7); 3.480 (3.3); 3.474 (3.1); 2.856 (7.0); 2.839 (15.5); 2.821 (8.5); 2.537 (0.7); 2.525 (0.9); 2.503 (3.6); 2.496 (3.6); 2.489 (6.6); 2.483 (5.7); 2.475 (6.0); 2.468 (7.3); 2.455 (4.5); 2.422 (1.1); 2.372 (3.0); 2.354 (6.9); 2.342 (5.3); 2.331 (6.6); 2.325 (5.4); 2.312 (6.9); 2.294 (2.8); 2.204 (2.0); 2.187 (5.2); 2.178 (5.5); 2.166 (8.4); 2.158 (6.0); 2.150 (4.8); 1.334 (1.2); 1.285 (1.8); 1.256 (2.3); 0.050 (0.6); 0.008 (3.3); 0.000 (102.5); 0.009 (4.3)

[0430] The present invention further provides for the use of at least one inventive compound selected from the group consisting of substituted cyclic aryl- and heteroarylcarbonyl hydrazides of the general formula (I), and of any desired mixtures of these inventive substituted cyclic aryl- and heteroarylcarbonyl hydrazides of the general formula (I), with further active agrochemical ingredients, for example fungicides, insecticides, herbicides, plant growth regulators or safeners, for enhancement of the resistance of plants to abiotic stress factors, preferably drought stress, and also for invigoration of plant growth and/or for increasing plant yield.

[0431] The present invention further provides a spray solution for treatment of plants, comprising an amount, effective for enhancement of the resistance of plants to abiotic stress factors, of at least one compound selected from the group consisting of the cyclic aryl- and heteroarylcarbonyl hydrazides of the general formula (I) having substitution in accordance with the invention. The abiotic stress conditions which can be relativized may include, for example, heat, drought, cold and aridity stress (stress caused by aridity and/or lack of water), osmotic stress, waterlogging, elevated soil salinity, elevated exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients.

[0432] In one embodiment, it is possible, for example, that the compounds envisaged in accordance with the invention, i.e. the appropriate cyclic aryl- and heteroarylcarbonyl hydrazides of the general formula (I) having substitution in accordance with the invention, are applied by spray application to appropriate plants or plant parts to be treated. The compounds of the general formula (I) or salts thereof are used as envisaged in accordance with the invention preferably with a dosage between 0.00005 and 3 kg/ha, more preferably between 0.0001 and 2 kg/ha, especially preferably between 0.0005 and 1 kg/ha, specifically preferably between 0.001 and 0.25 kg/ha.

[0433] The term resistance to abiotic stress is understood in the context of the present invention to mean various kinds of benefits for plants. Such advantageous properties are manifested, for example, in the following improved plant characteristics: improved root growth with regard to surface area and depth, increased stolon or tiller formation, stronger and more productive stolons and tillers, improvement in shoot growth, increased lodging resistance, increased shoot base diameter, increased leaf area, higher yields of nutrients and constituents, for example carbohydrates, fats, oils, proteins, vitamins, minerals, essential oils, dyes, fibers, better fiber quality, earlier flowering, increased number of flowers, reduced content of toxic products such as mycotoxins, reduced content of residues or disadvantageous constituents of any kind, or better digestibility, improved storage stability of the harvested material, improved tolerance to disadvantageous temperatures, improved tolerance to drought and aridity, and also oxygen deficiency as a result of waterlogging, improved tolerance to elevated salt contents in soils and water, enhanced tolerance to ozone stress, improved compatibility with respect to herbicides and other plant treatment compositions, improved water absorption and photosynthesis performance, advantageous plant properties, for example acceleration of ripening, more homogeneous ripening, greater attractiveness to beneficial animals, improved pollination, or other advantages well known to a person skilled in the art.

[0434] More particularly, the use of one or more inventive compounds of the general formula (I) exhibits the advantages described in spray application to plants and plant parts. In addition, the combined use of inventive substituted cyclic aryl- and heteroarylcarbonyl hydrazides of the general formula (I) with genetically modified cultivars with a view to increased tolerance to abiotic stress is likewise possible.

[0435] The further various benefits for plants mentioned above can be combined in a known manner in component form, and generally applicable terms can be used to describe them. Such terms are, for example, the following names: phytotonic effect, resistance to stress factors, less plant stress, plant health, healthy plants, plant fitness, plant wellness, plant concept, vigor effect, stress shield, protective shield, crop health, crop health properties, crop health products, crop health management, crop health therapy, plant health, plant health properties, plant health products, plant health management, plant health therapy, greening effect or regreening effect, freshness, or other terms with which a person skilled in the art is entirely familiar.

[0436] In the context of the present invention, a good effect on resistance to abiotic stress is understood to mean, without limitation, [0437] at least an emergence improved by generally 3%, especially more than 5%, more preferably more than 10%, [0438] at least a yield enhanced by generally 3%, especially more than 5%, more preferably more than 10%, [0439] at least a root development improved by generally 3%, especially more than 5%, more preferably more than 10%, [0440] at least a shoot size rising by generally 3%, especially more than 5%, more preferably more than 10%, [0441] at least a leaf area increased by generally 3%, especially more than 5%, more preferably more than 10%, [0442] at least a photosynthesis performance improved by generally 3%, especially more than 5%, more preferably more than 10%, and/or [0443] at least a flower development improved by generally 3%, especially more than 5%, more preferably more than 10%, and the effects may occur individually or else in any combination of two or more effects.

[0444] The present invention further provides a spray solution for treatment of plants, comprising an amount, effective for enhancement of the resistance of plants to abiotic stress factors, of at least one compound from the group of the cyclic aryl- and heteroarylcarbonyl hydrazides of the general formula (I) having substitution in accordance with the invention. The spray solution may comprise other customary constituents, such as solvents, formulation auxiliaries, especially water. Further constituents may include active agrochemical ingredients which are described in more detail below.

[0445] The present invention further provides for the use of corresponding spray solutions for increasing the resistance of plants to abiotic stress factors. The remarks which follow apply both to the use according to the invention of one or more compounds of the general formula (I) per se and to the corresponding spray solutions.

[0446] In accordance with the invention, it has additionally been found that the application of one or more inventive compounds of the general formula (I) in combination with at least one fertilizer as defined further below to plants or in their environment is possible.

[0447] Fertilizers which can be used in accordance with the invention together with the inventive compounds of the general formula (I) elucidated in detail above are generally organic and inorganic nitrogen-containing compounds, for example ureas, urea/formaldehyde condensation products, amino acids, ammonium salts and ammonium nitrates, potassium salts (preferably chlorides, sulfates, nitrates), salts of phosphoric acid and/or salts of phosphorous acid (preferably potassium salts and ammonium salts). In this context, particular mention should be made of the NPK fertilizers, i.e. fertilizers which contain nitrogen, phosphorus and potassium, calcium ammonium nitrate, i.e. fertilizers which additionally contain calcium, or ammonium sulfate nitrate (general formula (NH.sub.4).sub.2SO.sub.4 NH.sub.4NO.sub.3), ammonium phosphate and ammonium sulfate. These fertilizers are generally known to the person skilled in the art; see also, for example, Ullmann's Encyclopedia of Industrial Chemistry, 5th edition, Vol. A 10, pages 323 to 431, Verlagsgesellschaft, Weinheim, 1987.

[0448] The fertilizers may additionally comprise salts of micronutrients (preferably calcium, sulfur, boron, manganese, magnesium, iron, boron, copper, zinc, molybdenum and cobalt) and of phytohormones (for example vitamin B1 and indole-(III)-acetic acid) or mixtures of these. Fertilizers used in accordance with the invention may also contain other salts such as monoammonium phosphate (MAP), diammonium phosphate (DAP), potassium sulfate, potassium chloride, magnesium sulfate. Suitable amounts for the secondary nutrients or trace elements are amounts of 0.5% to 5% by weight, based on the overall fertilizer. Further possible ingredients are crop protection agents, for example fungicides, insecticides, herbicides, plant growth regulators or safeners, or mixtures thereof. Further details of these are given further down.

[0449] The fertilizers can be used, for example, in the form of powders, granules, prills or compactates. However, the fertilizers can also be used in liquid form, dissolved in an aqueous medium. In this case, dilute aqueous ammonia can also be used as a nitrogen fertilizer. Further possible ingredients for fertilizers are described, for example, in Ullmann's Encyclopedia of Industrial Chemistry, 5th edition, 1987, volume A 10, pages 363 to 401, DE-A 41 28 828, DE-A 19 05 834 and DE-A 196 31 764. The general composition of the fertilizers, which, in the context of the present invention, may take the form of straight and/or compound fertilizers, for example composed of nitrogen, potassium or phosphorus, may vary within a wide range. In general, a content of 1% to 30% by weight of nitrogen (preferably 5% to 20% by weight), of 1% to 20% by weight of potassium (preferably 3% to 15% by weight) and a content of 1% to 20% by weight of phosphorus (preferably 3% to 10% by weight) is advantageous. The microelement content is usually in the ppm range, preferably in the range from 1 to 1000 ppm.

[0450] In the context of the present invention, the fertilizer and one or more inventive compounds of the general formula (I) may be administered simultaneously. However, it is also possible first to apply the fertilizer and then one or more inventive compounds of the general formula (I), or first to apply one or more compounds of the general formula (I) and then the fertilizer. In the case of nonsynchronous application of one or more inventive compounds of the general formula (I) and the fertilizer, the application in the context of the present invention is, however, effected in a functional relationship, especially within a period of generally 24 hours, preferably 18 hours, more preferably 12 hours, specifically 6 hours, more specifically 4 hours, even more specifically within 2 hours. In very particular embodiments of the present invention, one or more compounds of the formula (I) according to the invention and the fertilizer are applied within a time frame of less than 1 hour, preferably less than 30 minutes, more preferably less than 15 minutes.

[0451] Preference is given to the use of inventive compounds of the general formula (I) on plants from the group of the useful plants, ornamentals, turfgrass types, commonly used trees which are used as ornamentals in the public and domestic sectors, and forestry trees. Forestry trees include trees for the production of timber, cellulose, paper and products made from parts of the trees. The term useful plants as used here refers to crop plants which are used as plants for obtaining foods, animal feeds, fuels or for industrial purposes.

[0452] The useful plants include, for example, the following types of plants: triticale, durum (hard wheat), turf, vines, cereals, for example wheat, barley, rye, oats, rice, corn and millet; beet, for example sugar beet and fodder beet; fruits, for example pome fruit, stone fruit and soft fruit, for example apples, pears, plums, peaches, almonds, cherries and berries, for example strawberries, raspberries, blackberries; legumes, for example beans, lentils, peas and soybeans; oil crops, for example oilseed rape, mustard, poppies, olives, sunflowers, coconuts, castor oil plants, cocoa beans and peanuts; cucurbits, for example pumpkin/squash, cucumbers and melons; fiber plants, for example cotton, flax, hemp and jute; citrus fruits, for example oranges, lemons, grapefruit and tangerines; vegetables, for example spinach, lettuce, asparagus, cabbage species, carrots, onions, tomatoes, potatoes and bell peppers; Lauraceae, for example avocado, Cinnamomum, camphor, or also plants such as tobacco, nuts, coffee, eggplant, sugar cane, tea, pepper, grapevines, hops, bananas, latex plants and ornamentals, for example flowers, shrubs, deciduous trees and coniferous trees. This enumeration does not constitute a limitation.

[0453] The following plants are considered to be particularly suitable target crops for the application of the method of the invention: oats, rye, triticale, durum, cotton, eggplant, turf, pome fruit, stone fruit, soft fruit, corn, wheat, barley, cucumber, tobacco, vines, rice, cereals, pears, pepper, beans, soybeans, oilseed rape, tomato, bell pepper, melons, cabbage, potatoes and apples.

[0454] Examples of trees which can be improved by the method of the invention include: Abies sp., Eucalyptus sp., Picea sp., Pinus sp., Aesculus sp., Platanus sp., Tilia sp., Acer sp., Tsuga sp., Fraxinus sp., Sorbus sp., Betula sp., Crataegus sp., Ulmus sp., Quercus sp., Fagus sp., Salix sp., Populus sp.

[0455] Preferred trees which can be improved by the method of the invention include: from the tree species Aesculus: A. hippocastanum, A. pariflora, A. carnea; from the tree species Platanus: P. aceriflora, P. occidentalis, P. racemosa; from the tree species Picea: P. abies; from the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P. albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P. jeffregi, P. baksiana, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus, E. camadentis, E. nitens, E. obliqua, E. regnans, E. pilularus.

[0456] Particularly preferred trees which can be improved by the method of the invention are: from the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus and E. camadentis.

[0457] Particularly preferred trees which can be improved by the method of the invention are: horse chestnut, Platanaceae, linden tree and maple tree.

[0458] The present invention can also be applied to any desired turfgrasses, including cool-season turfgrasses and warm-season turfgrasses. Examples of cool-season turfgrasses are bluegrasses (Poa spp.), such as Kentucky bluegrass (Poa pratensis L.), rough bluegrass (Poa trivialis L.), Canada bluegrass (Poa compressa L.), annual bluegrass (Poa annua L.), upland bluegrass (Poa glaucantha Gaudin), wood bluegrass (Poa nemoralis L.) and bulbous bluegrass (Poa bulbosa L.); bentgrasses (Agrostis spp.) such as creeping bentgrass (Agrostis palustris Huds.), colonial bentgrass (Agrostis tenuis Sibth.), velvet bentgrass (Agrostis canina L.), South German Mixed Bentgrass (Agrostis spp. including Agrostis tenius Sibth., Agrostis canina L., and Agrostis palustris Huds.), and redtop (Agrostis alba L.);

[0459] fescues (Festuca spp.), such as red fescue (Festuca rubra L. spp. rubra), creeping fescue (Festuca rubra L.), chewings fescue (Festuca rubra commutata Gaud.), sheep fescue (Festuca ovina L.), hard fescue (Festuca longifolia Thuill.), hair fescue (Festucu capillata Lam.), tall fescue (Festuca arundinacea Schreb.) and meadow fescue (Festuca elanor L.); ryegrasses (Lolium spp.), such as annual ryegrass (Lolium multiflorum Lam.), perennial ryegrass (Lolium perenne L.) and Italian ryegrass (Lolium multiflorum Lam.); and wheatgrasses (Agropyron spp.), such as fairway wheatgrass (Agropyron cristatum (L.) Gaertn.), crested wheatgrass (Agropyron desertorum (Fisch.) Schult.) and western wheatgrass (Agropyron smithii Rydb.).

[0460] Examples of further cool-season turfgrasses are beachgrass (Ammophila breviligulata Fern.), smooth bromegrass (Bromus inermis Leyss.), cattails such as Timothy (Phleum pratense L.), sand cattail (Phleum subulatum L.), orchardgrass (Dactylis glomerata L.), weeping alkaligrass (Puccinellia distans (L.) Parl.) and crested dog's-tail (Cynosurus cristatus L.).

[0461] Examples of warm-season turfgrasses are Bermudagrass (Cynodon spp. L. C. Rich), zoysiagrass (Zoysia spp. Willd.), St. Augustine grass (Stenotaphrum secundatum Walt Kuntze), centipedegrass (Eremochloa ophiuroides Munro Hack.), carpetgrass (Axonopus affinis Chase), Bahia grass (Paspalum notatum Flugge), Kikuyugrass (Pennisetum clandestinum Hochst. ex Chiov.), buffalo grass (Buchloe dactyloids (Nutt.) Engelm.), Blue gramma (Bouteloua gracilis (H.B.K.) Lag. ex Griffiths), seashore paspalum (Paspalum vaginatum Swartz) and sideoats grama (Bouteloua curtipendula (Michx. Torr.)). Cool-season turfgrasses are generally preferred for the inventive use. Particular preference is given to bluegrass, bentgrass and redtop, fescues and ryegrasses. Bentgrass is especially preferred.

[0462] Particular preference is given to using the inventive compounds of the general formula (I) to treat plants of the respective commercially available or commonly used plant cultivars. Plant cultivars are understood to mean plants which have new properties (traits) and which have been obtained by conventional breeding, by mutagenesis or with the aid of recombinant DNA techniques. Crop plants may thus be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which are protectable or non-protectable by plant breeders' rights.

[0463] The treatment method according to the invention can thus also be used for the treatment of genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants in which a heterologous gene has been stably integrated into the genome. The expression heterologous gene essentially means a gene which is provided or assembled outside the plant and when introduced into the nuclear, chloroplastic or hypochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing (an)other gene(s) which is/are present in the plant (using for example antisense technology, cosuppression technology or RNAi technology [RNA interference]). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its specific presence in the plant genome is called a transformation or transgenic event.

[0464] Plants and plant varieties which are preferably treated with the inventive compounds of the general formula (I) include all plants which have genetic material which imparts particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means or not).

[0465] Plants and plant varieties which can likewise be treated with the inventive compounds of the general formula (I) are those plants which are resistant to one or more abiotic stress factors. Abiotic stress conditions may include, for example, heat, drought, cold and aridity stress, osmotic stress, waterlogging, increased soil salinity, increased exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients or shade avoidance.

[0466] Plants and plant cultivars which can likewise be treated with the inventive compounds of the general formula (I) are those plants which are characterized by enhanced yield characteristics. Enhanced yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and nonstress conditions), including, but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and resistance to lodging. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and oil composition, nutritional value, reduction in antinutritional compounds, improved processibility and better storage stability.

[0467] Plants that may also be treated with the inventive compounds of the general formula (I) are hybrid plants that already express the characteristics of heterosis, or hybrid effect, which results in generally higher yield, higher vigor, better health and better resistance towards biotic and abiotic stress factors. Such plants are typically produced by crossing an inbred male-sterile parent line (the female crossbreeding parent) with another inbred male-fertile parent line (the male crossbreeding parent). Hybrid seed is typically harvested from the male-sterile plants and sold to growers. Male-sterile plants can sometimes (for example in corn) be produced by detasseling (i.e. mechanical removal of the male reproductive organs or male flowers); however, it is more typical for male sterility to be the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants, it is typically beneficial to ensure that male fertility in hybrid plants, which contain the genetic determinants responsible for male sterility, is fully restored. This can be accomplished by ensuring that the male crossbreeding parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described for Brassica species (WO 92/005251, WO 95/009910, WO 98/27806, WO 05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male-sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/002069).

[0468] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the inventive compounds of the general formula (I) are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.

[0469] Herbicide-tolerant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Thus, for example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), the genes encoding a petunia EPSPS (Shah et al., Science (1986), 233, 478-481), a tomato EPSPS (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289) or an Eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS, as described, for example, in EP-A 0837944, WO 00/066746, WO 00/066747 or WO 02/026995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxidoreductase enzyme as described in U.S. Pat. No. 5,776,760 and U.S. Pat. No. 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described, for example, in WO 02/036782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally occurring mutations of the abovementioned genes, as described, for example, in WO 01/024615 or WO 03/013226.

[0470] Other herbicide-resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition. One example of such an effective detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are described, for example, in U.S. Pat. No. 5,561,236; U.S. Pat. No. 5,648,477; U.S. Pat. No. 5,646,024; U.S. Pat. No. 5,273,894; U.S. Pat. No. 5,637,489; U.S. Pat. No. 5,276,268; U.S. Pat. No. 5,739,082; U.S. Pat. No. 5,908,810 and U.S. Pat. No. 7,112,665.

[0471] Further herbicide-tolerant plants are also plants that have been made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvate dioxygenase (HPPD). Hydroxyphenylpyruvate dioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is converted to homogentizate. Plants tolerant to HPPD inhibitors can be transformed with a gene encoding a naturally occurring resistant HPPD enzyme, or a gene encoding a mutated HPPD enzyme according to WO 96/038567, WO 99/024585 and WO 99/024586. Tolerance to HPPD inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite inhibition of the native HPPD enzyme by the HPPD inhibitor. Such plants and genes are described in WO 99/034008 and WO 2002/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding a prephenate dehydrogenase enzyme in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928.

[0472] Other herbicide-resistant plants are plants which have been rendered tolerant to acetolactate synthase (ALS) inhibitors. Known ALS inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pyrimidinyloxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxy acid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described, for example, in Tranel nd Wright, Weed Science (2002), 50, 700-712, and also in U.S. Pat. No. 5,605,011, U.S. Pat. No. 5,378,824, U.S. Pat. No. 5,141,870 and U.S. Pat. No. 5,013,659. The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants has been described in U.S. Pat. No. 5,605,011; U.S. Pat. No. 5,013,659; U.S. Pat. No. 5,141,870; U.S. Pat. No. 5,767,361; U.S. Pat. No. 5,731,180; U.S. Pat. No. 5,304,732; U.S. Pat. No. 4,761,373; U.S. Pat. No. 5,331,107; U.S. Pat. No. 5,928,937; and U.S. Pat. No. 5,378,824; and also in the international publication WO 96/033270. Further imidazolinone-tolerant plants have also been described, for example, in WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351 and WO 2006/060634. Further sulfonylurea- and imidazolinone-tolerant plants have also been described, for example, in WO 2007/024782.

[0473] Further plants tolerant to ALS-inhibitors, in particular to imidazolinones, sulfonylureas and/or sulfamoylcarbonyltriazolinones can be obtained by induced mutagenesis, by selection in cell cultures in the presence of the herbicide or by mutation breeding, as described, for example, for soybeans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugarbeet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599 or for sunflower in WO 2001/065922.

[0474] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the inventive compounds of the general formula (I) are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.

[0475] The term insect-resistant transgenic plant, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins compiled by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, updated by Crickmore et al. (2005) in the Bacillus thuringiensis toxin nomenclature (online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, for example proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae or Cry3Bb or insecticidal portions thereof; or
2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second, other crystal protein than Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cy34 and Cy35 crystal proteins (Moellenbeck et al., Nat. Biotechnol. (2001), 19, 668-72; Schnepf et al., Applied Environm. Microb. (2006), 71, 1765-1774); or
3) a hybrid insecticidal protein comprising parts of two different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, for example the Cry1A. 105 protein produced by corn event MON98034 (WO 2007/027777); or
4) a protein of any one of points 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes induced in the encoding DNA during cloning or transformation, such as the Cry3Bbl protein in maize events MON863 or MON88017, or the Cry3A protein in maize event MIR 604; or
5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal proteins (VIPs) listed under the following link, for example proteins from the VIP3Aa protein class: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html; or
6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or
7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
8) a protein of any one of points 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes induced in the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT 102.

[0476] Of course, insect-resistant transgenic plants, as used herein, also include any plant comprising a combination of genes encoding the proteins of any one of the abovementioned classes 1 to 8. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 8, to expand the range of the target insect species affected or to delay insect resistance development to the plants, by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.

[0477] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the compounds according to the invention of the general formula (I) are tolerant to abiotic stress factors. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress-tolerant plants include the following:

[0478] a. plants which contain a transgene capable of reducing the expression and/or the activity of the poly(ADP-ribose)polymerase (PARP) gene in the plant cells or plants, as described in WO 2000/004173 or EP 04077984.5 or EP 06109836.5;

[0479] b. plants which contain a stress tolerance-enhancing transgene capable of reducing the expression and/or the activity of the PARG-encoding genes of the plants or plant cells, as described, for example, in WO 2004/090140;

[0480] c. plants which comprise a stress-tolerance-enhancing transgene coding for a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage biosynthetic pathway, including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide adenine dinucleotide synthetase or nicotinamide phosphoribosyltransferase as described e.g. in EP 04077624.7 or WO 2006/133827 or PCT/EP07/002433.

[0481] Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the inventive compounds of the general formula (I) show altered quantity, quality and/or storage stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as, for example:

[0482] 1) Transgenic plants which synthesize a modified starch which, in its physicochemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behavior, the gelling strength, the starch granule size and/or the starch granule morphology, is changed in comparison with the synthesized starch in wild-type plant cells or plants, so that this modified starch is better suited to specific applications. These transgenic plants that synthesize a modified starch are described, for example, in EP 0571427, WO 95/004826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO 99/58690, WO 99/58654, WO 2000/008184, WO 2000/008185, WO 2000/28052, WO 2000/77229, WO 2001/12782, WO 2001/12826, WO 2002/101059, WO 2003/071860,

[0483] WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 2000/22140, WO 2006/063862, WO 2006/072603, WO 2002/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 2001/14569, WO 2002/79410, WO 2003/33540, WO 2004/078983, WO 2001/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341, WO 2000/11192, WO 98/22604, WO 98/32326, WO 2001/98509, WO 2001/98509, WO 2005/002359, U.S. Pat. No. 5,824,790, U.S. Pat. No. 6,013,861, WO 94/004693, WO 94/009144, WO 94/11520, WO 95/35026 and WO 97/20936.

[0484] 2) Transgenic plants which synthesize non-starch carbohydrate polymers or which synthesize non-starch carbohydrate polymers with altered properties in comparison to wild-type plants without genetic modification. Examples are plants which produce polyfructose, especially of the inulin and levan type, as described in EP 0663956, WO 96/001904, WO 96/021023, WO 98/039460 and

[0485] WO 99/024593, plants which produce alpha-1,4-glucans, as described in WO 95/031553, US 2002/031826, U.S. Pat. No. 6,284,479, U.S. Pat. No. 5,712,107,

[0486] WO 97/047806, WO 97/047807, WO 97/047808 and WO 2000/14249, plants which produce alpha-1,6-branched alpha-1,4-glucans, as described in WO 2000/73422, and plants which produce alternan, as described in WO 2000/047727, EP 06077301.7, U.S. Pat. No. 5,908,975 and EP 0728213.

[0487] 3) Transgenic plants which produce hyaluronan, as for example described in WO 06/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006/304779 and WO 2005/012529.

[0488] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the inventive compounds of the general formula (I) are plants, such as cotton plants, with altered fiber characteristics. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such altered fiber characteristics and include:

[0489] a) plants, such as cotton plants, which contain an altered form of cellulose synthase genes, as described in WO 98/000549;

[0490] b) plants, such as cotton plants, which contain an altered form of rsw2 or rsw3 homologous nucleic acids, as described in WO 2004/053219;

[0491] c) plants, such as cotton plants, with an increased expression of sucrose phosphate synthase, as described in WO 2001/017333;

[0492] d) plants, such as cotton plants, with an increased expression of sucrose synthase as described in WO 02/45485;

[0493] e) plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fiber cell is altered, for example through downregulation of fiber-selective -1,3-glucanase, as described in

[0494] WO 2005/017157;

[0495] f) plants, such as cotton plants, which have fibers with altered reactivity, for example through expression of the N-acetylglucosamine transferase gene including nodC and chitin synthase genes, as described in WO 2006/136351.

[0496] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the inventive compounds of the general formula (I) are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such altered oil characteristics and include:

[0497] a) plants, such as oilseed rape plants, which produce oil having a high oleic acid content, as described, for example, in U.S. Pat. No. 5,969,169, U.S. Pat. No. 5,840,946 or U.S. Pat. No. 6,323,392 or U.S. Pat. No. 6,063,947;

[0498] b) plants, such as oilseed rape plants, which produce oil having a low linolenic acid content, as described in U.S. Pat. No. 6,270,828, U.S. Pat. No. 6,169,190 or U.S. Pat. No. 5,965,755;

[0499] c) plants, such as oilseed rape plants, which produce oil having a low level of saturated fatty acids, as described, for example, in U.S. Pat. No. 5,434,283.

[0500] Particularly useful transgenic plants which may be treated with the inventive compounds of the general formula (I) are plants containing transformation events, or a combination of transformation events, and that are listed for example in the databases of various national or regional regulatory agencies.

[0501] Particularly useful transgenic plants which may be treated with the inventive compounds of the general formula (I) are, for example, plants which comprise one or more genes which encode one or more toxins and are the transgenic plants available under the following trade names: YIELD GARD (for example corn, cotton, soybeans), KnockOut (for example corn), BiteGard (for example corn), BT-Xtra (for example corn), StarLink (for example corn), Bollgard (cotton), Nucotn (cotton), Nucotn 33B (cotton), NatureGard (for example corn), Protecta and NewLeaf (potato). Examples of herbicide-tolerant plants include are corn varieties, cotton varieties and soya bean varieties which are available under the following trade names: Roundup Ready (tolerance to glyphosates, for example corn, cotton, soybeans), Liberty Link (tolerance to phosphinothricin, for example oilseed rape), IMI (tolerance to imidazolinone) and SCS (tolerance to sulfonylurea), for example corn. Herbicide-resistant plants (plants bred in a conventional manner for herbicide tolerance) which may be mentioned include the varieties sold under the name Clearfield (for example corn).

[0502] The compounds of the formula (I) to be used in accordance with the invention can be converted to customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, granules for broadcasting, suspoemulsion concentrates, natural compounds impregnated with active ingredient, synthetic substances impregnated with active ingredient, fertilizers, and also microencapsulations in polymeric substances. In the context of the present invention, it is especially preferred when the compounds of the general formula (I) are used in the form of a spray formulation.

[0503] The present invention therefore additionally also relates to a spray formulation for enhancing the resistance of plants to abiotic stress. A spray formulation is described in detail hereinafter:

[0504] The formulations for spray application are produced in a known manner, for example by mixing the inventive compounds of the general formula (I) for use in accordance with the invention with extenders, i.e. liquid solvents and/or solid carriers, optionally with use of surfactants, i.e. emulsifiers and/or dispersants and/or foam formers. Further customary additives, for example customary extenders and solvents or diluents, dyes, wetting agents, dispersants, emulsifiers, antifoams, preservatives, secondary thickeners, stickers, gibberellins and also water, can optionally also be used. The formulations are produced either in suitable facilities or else before or during application.

[0505] The auxiliaries used may be those substances which are suitable for imparting, to the composition itself and/or to preparations derived therefrom (for example spray liquors), particular properties such as particular technical properties and/or else special biological properties. Typical auxiliaries include: extenders, solvents and carriers.

[0506] Suitable extenders are, for example, water, polar and nonpolar organic chemical liquids, for example from the classes of the aromatic and nonaromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which, if appropriate, may also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulfones and sulfoxides (such as dimethyl sulfoxide).

[0507] If the extender utilized is water, it is also possible to use, for example, organic solvents as auxiliary solvents. Useful liquid solvents essentially include: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulfoxide, and also water.

[0508] It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian blue, and organic colorants such as alizarin colorants, azo colorants and metal phthalocyanine colorants, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

[0509] Suitable wetting agents which may be present in the formulations which can be used in accordance with the invention are all substances which promote wetting and which are conventionally used for the formulation of agrochemical active substances. Preference is given to using alkyl naphthalenesulfonates, such as diisopropyl or diisobutyl naphthalenesulfonates.

[0510] Suitable dispersants and/or emulsifiers which may be present in the formulations which can be used in accordance with the invention are all nonionic, anionic and cationic dispersants conventionally used for the formulation of active agrochemical ingredients. Preference is given to using nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants. Suitable nonionic dispersants include in particular ethylene oxide/propylene oxide block polymers, alkylphenol polyglycol ethers and tristyrylphenol polyglycol ethers, and the phosphated or sulfated derivatives thereof. Suitable anionic dispersants are especially lignosulfonates, polyacrylic acid salts and arylsulfonate-formaldehyde condensates.

[0511] Antifoams which may be present in the formulations usable in accordance with the invention are all foam-inhibiting substances customary for the formulation of active agrochemical ingredients. Silicone antifoams and magnesium stearate can be used with preference.

[0512] Preservatives which may be present in the formulations usable in accordance with the invention are all substances usable for such purposes in agrochemical compositions. Examples include dichlorophene and benzyl alcohol hemiformal.

[0513] Secondary thickeners which may be present in the formulations usable in accordance with the invention are all substances usable for such purposes in agrochemical compositions. Preferred examples include cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and finely divided silica.

[0514] Stickers which may be present in the formulations usable in accordance with the invention include all customary binders usable in seed-dressing products. Preferred examples include polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose.

[0515] Suitable gibberellins which may be present in the formulations which can be used in accordance with the invention are preferably the gibberellins A1, A3 (=gibberellic acid), A4 and A7; gibberellic acid is especially preferably used. The gibberellins are known (cf. R. Wegler Chemie der Pflanzenschutz-und Schadlingsbekampfungsmittel, vol. 2, Springer Verlag, 1970, pp. 401-412).

[0516] Further additives may be fragrances, mineral or vegetable, optionally modified oils, waxes and nutrients (including trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc. Additionally present may be stabilizers, such as cold stabilizers, antioxidants, light stabilizers or other agents which improve chemical and/or physical stability.

[0517] The formulations contain generally between 0.01% and 98% by weight, preferably between 0.5% and 90%, of the compound of the general formula (I).

[0518] The inventive compounds of the general formula (I) may be present in commercially available formulations, and also in the use forms, prepared from these formulations, in a mixture with other active compounds, such as insecticides, attractants, sterilizing agents, bactericides, acaricides, nematicides, fungicides, growth-regulating substances, herbicides, safeners, fertilizers or semiochemicals.

[0519] In addition, the described positive effect of the compounds of the formula (I) on the plants' own defenses can be supported by an additional treatment with active insecticidal, fungicidal or bactericidal compounds.

[0520] Preferred times for the application of compounds of the general formula (I) to be used according to the invention or salts thereof for enhancing resistance to abiotic stress are treatments of the soil, stems and/or leaves with the approved application rates.

[0521] The inventive active ingredients of the general formula (I) or salts thereof may generally additionally be present in their commercial formulations, and in the use forms prepared from these formulations, in mixtures with other active ingredients, such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, bactericides, growth regulators, substances which influence plant maturity, safeners or herbicides.

[0522] The invention is to be illustrated by the biological examples which follow, but without restricting it thereto.

Biological Examples

[0523] In Vivo Analyses

[0524] Seeds of monocotyledonous and dicotyledonous crop plants were sown in sandy loam in wood-fiber or plastic pots, covered with soil or sand and cultivated in a greenhouse under good growth conditions. The trial plants were treated at the early leaf stage (BBCH10-BBCH13). To assure uniform water supply before commencement of stress, the potted plants were supplied with water by dam irrigation prior to substance application.

[0525] The inventive compounds formulated in the form of wettable powders (WP) were sprayed onto the green parts of the plants as an aqueous suspension at an equivalent water application rate of 600 I/ha with addition of 0.2% wetting agent (e.g. agrotin). Substance application was followed immediately by stress treatment of the plants. For this purpose, the wood-fiber pots were transferred in plastic inserts in order to prevent them from subsequently drying out too quickly.

[0526] Drought stress was induced by gradual drying out under the following conditions:

[0527] Day: 14 hours with illumination at 26-30 C.

[0528] Night: 10 hours without illumination at 18-20 C.

[0529] The duration of the respective stress phases was guided mainly by the condition of the stressed control plants. It was ended (by re-irrigating and transfer to a greenhouse with good growth conditions) as soon as irreversible damage was observed on the stressed control plants.

[0530] The end of the stress phase was followed by an about 4-7-day recovery phase, during which the plants were once again kept under good growth conditions in a greenhouse. The duration of the recovery phase was guided mainly by when the trial plants had attained a state which enabled visual scoring of potential effects, and is therefore variable.

[0531] Once this juncture was reached, the intensities of damage were scored visually in comparison to untreated, unstressed controls of the same age. The damage intensity was at first assessed in percent. These values were then used to calculate the efficacy of the test compounds by the following formula:

[00001]$\mathrm{EF}=\frac{\left({\mathrm{SI}}_s-{\mathrm{SI}}_t\right)100}{{\mathrm{DI}}_s}$

[0532] EF: Efficacy

[0533] DI.sub.s: Damage intensity of the stressed control plants

[0534] DI.sub.t: Damage intensity of the stressed plants treated with test compound

[0535] The values reported in tables A-1 to A-3 below are mean values from at least one trial with at least two repeats, showing the effects of selected compounds of the general formula (I) under drought stress on various crop plants.

TABLE-US-00002 TABLE A-1 EF [%] No. Substance Dosage Unit (BRSNS) 1 A2-122 250 g/ha >5% 2 A6-37 2.5 g/ha >5% 3 B2-61 25 g/ha >5% 4 B2-462 25 g/ha >5% 5 C6-61 2.5 g/ha >5% 6 C7-1 2.5 g/ha >5% 7 C8-2 250 g/ha >5% 8 C8-62 2.5 g/ha >5% 9 C8-108 2.5 g/ha >5%

TABLE-US-00003 TABLE A-2 EF [%] No. Substance Dosage Unit (ZEAMX) 1 A2-37 25 g/ha >5% 2 A2-122 250 g/ha >5% 3 A3-21 250 g/ha >5% 4 A5-6 250 g/ha >5% 5 A6-1 250 g/ha >5% 6 A6-121 25 g/ha >5% 7 B2-61 250 g/ha >5% 8 C4-61 250 g/ha >5% 9 C8-62 250 g/ha >5%

TABLE-US-00004 TABLE A-3 EF [%] No. Substance Dosage Unit (TRZAS) 1 A2-37 250 g/ha >5% 2 A2-122 250 g/ha >5% 3 A6-1 25 g/ha >5% 4 B2-61 25 g/ha >5% 5 C4-61 25 g/ha >5% 6 C6-61 25 g/ha >5% 7 C8-108 25 g/ha >5%

[0536] In Vivo AnalysesPart B

[0537] Seeds of monocotyledonous and dicotyledonous crop plants were sown in sandy loam in plastic pots, covered with soil or sand and cultivated in a greenhouse under good growth conditions. The test plants are treated at the early leaf stage (BBCH10-BBCH13). To assure uniform water supply before commencement of stress, the potted plants were supplied with water by dam irrigation prior to substance application.

[0538] The inventive compounds were first formulated as wettable powders (WP) or dissolved in a solvent mixture. The further dilution was effected with water supplemented with 0.2% wetting agent (e.g. agrotin). The finished spray liquor was sprayed onto the green parts of the plant at an equivalent water application rate of 600 l/ha. Substance application was followed immediately by stress treatment of the plants.

[0539] Drought stress was induced by gradual drying out under the following conditions:

[0540] Day: 14 hours with illumination at 26-30 C.

[0541] Night: 10 hours without illumination at 18-20 C.

[0542] The duration of the respective stress phases was guided mainly by the condition of the stressed control plants. It was ended (by re-irrigating and transfer to a greenhouse with good growth conditions) as soon as irreversible damage was observed on the stressed control plants.

[0543] The end of the stress phase was followed by an about 4-7-day recovery phase, during which the plants were once again kept under good growth conditions in a greenhouse. The duration of the recovery phase was guided mainly by when the trial plants had attained a state which enabled visual scoring of potential effects, and was therefore variable.

[0544] Once this juncture had been reached, the appearance of the plants treated with test substances was recorded in comparison to the stressed control plants by the following categories: [0545] 0 no positive effect [0546] + slight positive effect [0547] ++ clear positive effect [0548] +++ strong positive effect

[0549] In order to rule out any influence on the effects observed by any fungicidal or insecticidal action of the test compounds, it was additionally ensured that the tests proceeded without fungal infection or insect infestation.

[0550] The values reported in tables B-1 and B-2 below are mean values of the results from at least three repeats.

[0551] Effects of selected compounds of the general formula (I) under drought stress according to the following tables B-1 and B-2:

TABLE-US-00005 TABLE B-1 Effect No. Substance Dosage Unit (BRSNS) 1 A2-15 250 g/ha + 2 A7-15 250 g/ha + 3 A12-21 250 g/ha + 4 A12-40 250 g/ha + 5 A13-1 250 g/ha + 6 A13-61 25 g/ha + 7 A14-61 250 g/ha + 8 B2-36 250 g/ha + 9 B2-159 250 g/ha + 10 B5-11 250 g/ha + 11 B5-21 250 g/ha + 12 B5-61 250 g/ha + 13 B6-21 250 g/ha + 14 B7-21 25 g/ha + 15 F1-61 25 g/ha +

TABLE-US-00006 TABLE B-2 Effect No. Substance Dosage Unit (TRZAS) 1 A2-15 250 g/ha + 2 A7-15 25 g/ha + 3 A7-94 25 g/ha + 4 A8-15 25 g/ha + 5 A9-15 25 g/ha + 6 A12-1 250 g/ha + 7 A12-40 25 g/ha + 8 A13-1 250 g/ha + 9 A13-21 250 g/ha + 10 A13-40 250 g/ha + 11 A14-61 25 g/ha + 12 B2-15 250 g/ha + 13 B2-36 25 g/ha + 14 B2-94 25 g/ha + 15 B2-159 250 g/ha + 16 B5-61 250 g/ha + 17 B6-1 250 g/ha + 18 B6-21 250 g/ha + 19 B6-61 250 g/ha + 20 B7-1 25 g/ha ++ 21 B7-61 250 g/ha + 22 F1-61 100 g/ha +

[0552] In the above tables:

[0553] BRSNS=Brassica napus

[0554] ZEAMX=Zea mays

[0555] TRZAS=Triticum aestivum