4-[4-({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE MONOHYDRATE

Abstract

The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.

Claims

1. A compound of the formula (II) ##STR00003##

2. The compound of claim 1 which shows in the X-ray diffractometry a peak maximum of the 2 Theta angel of 21.2.

3. The compound of claim 1 which shows in the FIR spectrum a peak maximum of 353 cm.sup.1.

4. A process for the preparation of the compound of the formula (II) of claim 1 which comprises dissolution of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide and adding water until precipitation.

5. The preparation of the compound of the formula (II) of claim 1 which comprises suspension of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide in an aqueous solvent and then stiffing or shaking until conversion to the compound of the formula (II).

6. A compound of the formula (II) of claim 1 for the treatment of hyper-proliferative disorders.

7. A compound of the formula (II) of claim 1 for the treatment of solid tumors, lymphomas, sarcomas, leukemias, cancers of the breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, skin, head and neck, thyroid and/or parathyroid.

8. A use of the compound of the formula (II) of claim 1 for the preparation of a pharmaceutical composition for the treatment of hyper-proliferative disorders.

9. The use of claim 8 for the treatment of solid tumors, lymphomas, sarcomas, leukemias, cancers of the breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, skin, head and neck, thyroid and/or parathyroid.

10. A pharmaceutical composition comprising the compound of the formula (II) of claim 1 mainly, no significant fractions of another form of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide and one or more inert, nontoxic, pharmaceutically suitable excipients.

11. The pharmaceutical composition of claim 10 containing more than 90 percent by weight of the compound of the formula (II) related to the total amount of the compound of the formula (II) present in the composition.

12. The pharmaceutical composition of claim 10 for the treatment of disorders.

13. A method for treating hyper-proliferative disorders using an effective amount of the compound of the formula (II) of claim 1 or of a pharmaceutical composition as defined in.

14. A combination comprising the compound of the formula (II) of claim 1 and one or more other pharmaceutical agents.

15. The combination of claim 14 wherein the one or more other pharmaceutical agents are cytotoxic agents, signal transduction inhibitors, anti-cancer agents, or antiemetics.

16. The pharmaceutical composition of claim 10 comprising one or more other pharmaceutical agents.

17. The pharmaceutical composition of claim 16 wherein the one or more other pharmaceutical agents are anti-hyper-proliferative agents, cytotoxic agents, signal transduction inhibitors, anti-cancer agents and/or antiemetics.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0144] FIGS. 1-7 are graphs.

WORKING EXAMPLES

[0145] The thermograms are obtained using a DSC 7 or Pyris-1 differential scanning calorimeter and TGA 7 thermogravimetric analyzer from Perkin-Elmer. The X-ray diffractograms are registered in a Stoe transmission diffractometer. The IR, FIR, NIR and Raman spectra are recorded using IFS 66v (IR, FIR), IFS 28/N (NIR) and RFS 100 (Raman) Fourier spectrometers from Bruker. The .sup.13C-solid state NMR spectra are recorded using the NMR spectrometer DRX400 from Bruker.

Example 1: Preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate

Example 1.1

[0146] 400 mg of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide in the polymorph I, prepared as described in WO 2005/009961, are dissolved in acetone and the solution is filtered. Water is added to one fourth of the filtrate until precipitation. The precipitate is filtered and dried at room temperature under ambient humidity. The sample is tested gravimetrically and corresponds to the title compound.

Example 1.2

[0147] 400 mg of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide in the polymorph I, prepared as described in WO 2005/009961, are dissolved in 50 ml of ethanol and the solution is filtered. One fourth of the solution is stayed in the freezer for crystallization at about 20 C. until the solvent is evaporated. The residue is tested by X-ray diffractometry and corresponds to the title compound.

Example 1.3

[0148] 100 mg of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide in the polymorph I, prepared as described in WO 2005/009961, are suspended in 2 ml of a mixture of acetonitril-water (1:1) and shaken at 25 C. After one week the suspension is filtered and the residue is dried at room temperature and ambient humidity. The residue is tested gravimetrically and corresponds to the title compound.

Example 1.4

[0149] 100 mg of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide in the polymorph I, prepared as described in WO 2005/009961, are suspended in 2 ml of a mixture of tetrahydrofuran-water (1:1) and stirred at 10 C. After two weeks the suspension is filtered and the residue is dried at room temperature and ambient humidity. The residue is tested by X-ray diffractometry and corresponds to the title compound.

TABLE-US-00001 TABLE 1 Differential Scanning Calorimetry and Thermogravimetry Monohydrate Polymorph I Melting point [ C.] 186-206 Loss in mass [% by wt.] 3.6 <0.4

TABLE-US-00002 TABLE 2 X-ray diffractometry Peak maxima [2 Theta] Monohydrate Polymorph I 5.9 7.2 8.1 7.3 9.5 8.6 11.8 10.7 14.9 11.5 16.2 12.1 16.7 13.4 17.2 13.6 17.7 14.0 18.6 14.5 19.0 14.8 20.5 15.6 20.8 16.0 21.2 16.5 22.0 17.2 22.2 18.6 22.4 18.8 22.8 19.1 23.1 19.8 23.7 20.1 24.1 20.2 24.3 20.4 24.7 21.8 24.9 22.9 26.0 23.5 26.2 23.8 26.3 24.2 27.1 24.9 27.2 25.2 27.6 25.9 27.8 26.0 28.7 26.4 29.2 26.6 30.8 27.2 27.4 28.2 29.1 29.4 30.4 30.9 31.6 32.7 33.0 33.4 35.1 35.3 35.8 36.1 36.6 37.3

TABLE-US-00003 TABLE 3 IR spectroscopy Peak maxima [cm.sup.1] Monohydrate Polymorph I 509 512 536 535 577 563 648 572 662 654 694 722 710 744 723 785 749 811 792 836 807 871 817 880 839 906 852 970 863 996 884 1030 900 1044 914 1108 964 1116 997 1131 1029 1143 1102 1151 1123 1176 1146 1207 1162 1233 1192 1246 1225 1261 1247 1300 1256 1317 1266 1336 1298 1416 1311 1431 1323 1471 1336 1487 1411 1506 1431 1546 1469 1572 1485 1596 1498 1657 1544 1720 1573 3077 1591 3255 1609 3306 1656 3350 1716 3389 3108 3252 3375

TABLE-US-00004 TABLE 4 Raman spectroscopy Peak maxima [cm.sup.1] Monohydrate Polymorph I 85 85 116 105 146 151 176 213 186 245 228 317 241 340 281 352 318 375 356 397 385 438 443 457 541 465 564 551 649 659 661 691 698 701 750 746 793 786 807 811 844 849 861 921 920 970 997 997 1031 1030 1103 1099 1116 1111 1128 1116 1258 1209 1267 1261 1290 1284 1313 1300 1336 1314 1410 1336 1501 1405 1556 1427 1573 1504 1592 1541 1610 1597 1628 1613 1715 1657 2951 1717 3069 2951 3104 3071 3090

TABLE-US-00005 TABLE 5 FIR spectroscopy Peak maxima [cm.sup.1] Monohydrate Polymorph I 109 99 134 117 153 155 172 166 191 187 239 207 265 217 307 231 318 241 353 263 364 297 384 306 403 318 431 329 441 341 453 367 461 375 485 396 438 454 463

TABLE-US-00006 TABLE 6 NIR spectroscopy Peak maxima [cm.sup.1] Monohydrate Polymorph I 4097 4041 4221 4098 4512 4190 4584 4230 4660 4296 4784 4414 4906 4542 5127 4604 6025 4681 6605 4808 4924 6033 6632 8858

TABLE-US-00007 TABLE 7 .sup.13C-solid state-NMR spectroscopy Peak maxima [ppm] Monohydrate Polymorph I 28 25 110 105 115 112 117 116 121 121 126 125 133 127 139 131 151 139 167 149 150 152 166