FORMULATIONS PROVIDING LONG-LASTING FRAGRANCE PERFORMANCE

Abstract

The present invention provides long-lasting fragrance compositions that impart to a consumer a long-lasting perception and/or intensity of a perfume during fragrance wear. The present invention provides long-lasting fragrance compositions for prolonging the performance of a fragrance oil.

Claims

1. A long-lasting fragrance composition comprising: a. a fragrance oil, b. 0.01% to 40% w/w of the long-lasting fragrance composition of an amphiphilic oil-soluble compound, c. a volatile solvent, and d. water.

2. The long-lasting fragrance composition of claim 1, wherein the amphiphilic oil-soluble compound is 0.5% to 30% w/w of the long-lasting fragrance composition.

3. The long-lasting fragrance composition of claim 1, wherein the wherein the amphiphilic oil-soluble compound includes a compound having one of the following chemical structures: ##STR00013## where n represents the number of CH2 groups and is greater than 14 and m represents the number of unsaturated C—C bounds and is greater than or equal to 1, and Ri is selected from the group consisting of: ##STR00014## ##STR00015## serinolamide, methylpropanediolamide, ethylpropanediolamide, urea, a urea alcohol, biuret, a biuret alcohol, anandamine, glycerol ether, a glycolipid, and a combination thereof.

4. The long-lasting fragrance composition of claim 1, further comprising a gelator, wherein the gelator is 0.01 to 15% w/w of the long-lasting fragrance composition.

5. The long-lasting fragrance composition of claim 4, wherein the gelator is 0.3 to 0.6% w/w of the long-lasting fragrance composition.

6. The long-lasting fragrance composition of claim 4, wherein the gelator is selected from the group consisting of: an n-alkane having a greater than 16 length CH.sub.2 chain, a hydroxyalkanoic acid, hydroxy-octadecanoyl, hydroxy-hexadecanoyl, a dihydroxyalkanoic acid, a dicarboxylic acid, a fatty acids alkyl ester with an alkyl chain length greater than 20 CH.sub.2 groups, a hydroxyalkanoic alcohol, a glycyrrhizic acid, caffeine, an anthryl derivatives, dendrimers n-alkanes, oligo(p-phenylenevinylene), dipyridylurea—carboxylic acid combination, diamine linked Dendron, dibutyl ethylhexanoyl glutamide, dibutyl lauroyl monoglycerol, dibutyl lauroyl 2-glycerol, dibutyl lauroyl glycerate, dibutyl lauroyl glyceryl ether, dibutyl lauroyl monoethanolamide, dibutyl lauroyl diethanolamide, dibutyl lauroyl glutamide, an organogelator, an amino acid-based gelator, a hydroxyfatty acid gelator, ester gum, cellulose derivatives, and combinations thereof.

7. The long-lasting fragrance composition of claim 1, wherein the water is 0.01 to 60% w/w of the long-lasting fragrance composition.

8.-11. (canceled)

12. The long-lasting fragrance composition of claim 1, wherein the volatile solvent is selected from the group consisting of: ethanol, isopropyl alcohol, an ether, and mixtures thereof.

13. The long-lasting fragrance composition of claim 1, further comprising a modulator.

14. The long-lasting fragrance composition of claim 13, wherein the modulator is selected from the group consisting of: methyl glucoside polyol; ethyl glucoside polyol; propyl glucoside polyol; isocetyl alcohol; PPG-3 myristyl ether; neopentyl glycol diethylhexanoate; sucrose laurate; sucrose dilaurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose distearate, sucrose tristearate, hyaluronic acid disaccharide sodium salt, sodium hyaluronate, propylene glycol propyl ether; dicetyl ether; polyglycerin-4 ethers; isoceteth-5; isoceteth-7, isoceteth-10; isoceteth-12; isoceteth-15; isoceteth-20; isoceteth-25; isoceteth-30; di sodium lauroamphodipropionate; hexaethylene glycol monododecyl ether; neopentyl glycol diisononanoate; cetearyl ethylhexanoate; panthenol ethyl ether, DL-panthenol, N-hexadecyl n-nonanoate, noctadecyl n-nonanoate, nerolidol, polymethylol, a profragrance, a cooling agent, a cyclodextrin, an encapsulation, a fatty acid, oleic acid, a fatty alcohol, oleic alcohol, a polyglyceride fatty acid, diglycerol oleate, and a combination thereof.

15. The long-lasting fragrance composition of claim 1, wherein the amphiphilic oil-soluble compound is glycerol monooleate or phytantriol or a combination thereof.

16. The long-lasting fragrance composition according to claim 13 wherein the modulator is nerolidol.

17. The long-lasting fragrance composition of claim 13, which comprises: 1% to 10% w/w of the composition of the amphiphilic oil-soluble compound; 0.5% to 15% w/w of the composition of the modulator, 0.1% to 10% w/w of the composition of the gelator, and 1% to 40% w/w of the composition of water.

18. (canceled)

19. (canceled)

20. The long-lasting composition of claim 17 wherein the amphiphilic oil-soluble compound is glycerol monooleate, the gelator is dibutylhexanyl glutamide, and the modulator is selected from the group consisting of: nerolidol, polymethylol, and a combination thereof.

21. The long-lasting fragrance composition of claim 1, wherein 40 to 100% of the fragrance oil is a volatility component comprising at least one perfume raw material having a vapor pressure greater than 0.0008 Torr at 22° C.

22. The long-lasting fragrance composition of claim 21, wherein the volatility component comprises at least one perfume raw material having a vapor pressure greater than 0.08 torr.

23. The long-lasting fragrance composition of claim 22, further comprising a second perfume raw material having a vapor pressure greater than 0.08 Torr at 22° C.

24. The long-lasting fragrance composition of claim 22, wherein 0.08 to 85% of the fragrance oil is a volatility component comprising at least one perfume raw material having a vapor pressure in the range of 0.0008 to 0.08 Torr at 22° C.

25. The long-lasting fragrance composition of claim 24, further comprising a second perfume raw material having a vapor pressure in the range of 0.0008 to 0.08 Torr at 22° C.

26. A leave-on volatile solvent-containing consumer product comprising the long-lasting fragrance composition of claim 1.

27.-30. (canceled)

Description

BRIEF DESCRIPTION OF THE FIGURES

[0024] FIG. 1 is a bar graph showing the relative intensity of fragrance ingredient styrallyl acetate, solubilized in the formulations EDT 1-4 in the head space at different moments of evaporation.

[0025] FIG. 2 is a bar graph showing the relative intensity of fragrance A ingredients after 6 h of evaporation from formulations EDT2 (with gelator AGA)

[0026] FIG. 3 is a bar graph showing the effect of compound concentration on fragrance retention after 6 hours evaporation at 32° C.

[0027] FIG. 4 is a bar graph showing results from a sensory panel comparison of Fragrance SP in EDT without and with 3% GMO, Fragrance SP in EDT without and with 5% ICA, and Fragrance SP in EDT without and with 3% GMO+5% ICA. There was no difference with 3% GMO; there was a significant difference with 5% ICA at 4 and 5 hours; and there was a significant difference with 3% GMO+5% ICA at 5 and 6 hours.

[0028] FIG. 5 is a bar graph showing the results from a sensory panel comparison using a mixture of GMO and Hedione. Sensory panels compared Fragrance SP in EDT without and with 3% GMO; Fragrance SP in EDT without and with 5% Hedione; and Fragrance SP in EDT without and with 3% GMO+5% Hedione. There was no difference with 3% GMO, there was a significant difference from 2 to 4 hours with 5% Hedione, there was a significant difference from 2 to 6 hours with 3% GMO+5% Hedione: significant difference. There was a higher performance of the formulation containing the mixture GMO-Hedione after 2 hours of evaporation.

[0029] FIG. 6 a and b are bar graphs showing the performance of two highly volatile fragrance ingredients, benzyl acetate and dihydromyrcenol, after evaporation at 2, 4 and 6 hours and compared it to the performance of the reference sample EDT0 (value 1). The intensity of the fragranced ingredients after 6 hours of evaporation was significantly higher in the presence of phytantriol and the mixture of phytantriol and gelator.

[0030] FIG. 7 a and b are bar graphs showing the intensity of (A) benzyl acetate with 10% phytantriol, and benzyl acetate with 10% phytantriol and β-cyclodextrin (CD); and (B) dihydromyrcenol with 10% phytantriol, and dihydromyrcenol with 10% phytantriol and β-cyclodextrin.

[0031] FIG. 8 is a graph showing the total area sums throughout evaporation of 5% Phytantriol 2% Polymethylol and 0.3% EB21 with Research Accord HT1 formula vs. RAHT1 formula alone. The data shows a higher retention of the sum of all compounds with 5% Phytantriol 2% Polymethylol and 0.3% EB21 throughout the entire evaporation against the control.

[0032] FIG. 9 is a graph showing total area sums throughout evaporation of 5% Phytantriol 2% Schercemol and 0.3% EB21 with Research Accord HT1 formula vs. RAHT1 formula alone. The data shows a higher retention of the sum of all compounds with 5% Phytantriol 2% Schercemol and 0.3% EB21 throughout the entire evaporation against the control.

[0033] FIG. 10 is a graph showing direct injection data at 1 hour evaporation of 5% Phytantriol 2% Polymethylol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds and most noticeably high and mid volatility notes on the left.

[0034] FIG. 11 is a graph showing direct Injection data at 1 hour evaporation of 5% Phytantriol 2% Schercemol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds and most noticeably high and mid volatility notes on the left.

[0035] FIG. 12 is a graph showing direct Injection data at 2 hours evaporation of 5% Phytantriol 2% Polymethylol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds and most noticeably high and mid volatility notes on the left.

[0036] FIG. 13 is a graph showing direct Injection data at 2 hours evaporation of 5% Phytantriol 2% Schercemol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds and most noticeably high and mid volatility notes on the left.

[0037] FIG. 14 is a graph showing direct Injection data at 4 hours evaporation of 5% Phytantriol 2% Polymethylol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds—most noticeably mid and low volatility notes on the right—even after most of the high volatility notes on the left has evaporated by 4 hours.

[0038] FIG. 15 is a graph showing direct Injection data at 4 hours evaporation of 5% Phytantriol 2% Schercemol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds—most noticeably mid and low volatility notes on the right—even after most of the high volatility notes on the left has evaporated by 4 hours.

[0039] FIG. 16 is a graph showing direct injection data at 6 hours evaporation of 5% Phytantriol 2% Polymethylol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds—most noticeably mid and low volatility notes on the right—even after the high volatility notes on the left has evaporated by 6 hours.

[0040] FIG. 17 is a graph showing direct injection data at 6 hours evaporation of 5% Phytantriol 2% Schercemol and 0.3% EB21 with Research accord HT1 formula vs. HT1 formula alone. The data shows a higher retention of all compounds—most noticeably mid and low volatility notes on the right—even after the high volatility notes on the left has evaporated by 6 hours.

DETAILED DESCRIPTION

[0041] The present invention provides compositions that prolong the performance of a fragrance oil. A “long-lasting fragrance composition” as used herein means that a fragrance oil according to the present invention has prolonged performance relative to the fragrance oil alone. Prolonged performance may be measured by methods known in the art. For example, by quantitative GC-MS analysis following evaporation kinetics; by sensory panels rating over all intensity or rating olfactive attributes.

[0042] The present invention provides compositions that improve fragrance performance by imparting consumer-perceived long-lasting perception of a perfume during fragrance wear while maintaining a clear, transparent, sprayable and stable hydro-alcoholic formulation and solution with an acceptable skin feel.

[0043] A long-lasting fragrance composition of the present invention is suitable for volatile solvent (ethanol, for example)-containing consumer fragrance products for the skin or hair. In an embodiment, a long-lasting fragrance composition of the present invention may be dispensed using an atomizer in a micronized mist, which will enhance the fragrance performance thanks to the use of a dispensing system composed of a multichannel nozzle.

[0044] A long-lasting fragrance composition of the present invention can be diluted by a solvent (e.g., ethanol)—water mixture in order to obtain a final consumer product such as a Parfum, Eau de toilette, Eau de parfum, Body-mist, Body spray, Body splash, deodorant, Hair mist, lotion, air care products, and other solvent-based consumer products. Optionally the long-lasting fragrance composition can be coupled with non-odoriferous fragrance modulators, odoriferous fragrance modulators, entrapment macromolecule like cyclodextrins, and/or profragrances in order to enhance the long-lasting benefits.

[0045] A composition according to the present invention may include: A) hydrophobic active such as a fragrance oil; B) an amphiphilic oil-soluble compound; C) a volatile solvent (such as ethanol) having an evaporation rate or a vapor pressure higher than that of water (VP=3.17 kPa at 25° C. and 5.62 kPa at 35° C.); D) water; E) a low molecular weight gelator and optionally F) a hydroptopic salt.

[0046] An amphiphilic oil-soluble compound of the present invention includes a compound having one of the following chemical structures:

##STR00009##

where n represents the number of CH2 groups and is greater than 14, m represents the number of unsaturated C—C bounds and is greater than or equal to 1, and Ri is one or a combination of the following groups:

##STR00010## ##STR00011## ##STR00012##

serinolamide, methylpropanediolamide, ethylpropanediolamide, urea, a urea alcohols, biuret, a biuret alcohol, anandamine, glycerol ether, and/or a glycolipid. The amphiphilic oil-soluble compound is soluble in the volatile solvent, not soluble or slightly soluble in water, and has a packing parameter >1.

[0047] In certain aspects, the amphiphilic oil-soluble compound is glycerol monooleate, phytantriol, a long chain fatty acid (CH.sub.2 greater than 14), or a surfactant with a hydrophilic-lipid balance (HLB) less than 10.

[0048] An amphiphilic oil-soluble compound may be a surface active compound such as a surfactant having a HLB<10, long-chained fatty acids and fatty alcohols having CH2>14 such as myristyl, palmityl, oleyl, docosanoyl, and others.

[0049] A “fragrance oil” according to the present invention includes fragrance, fragrance ingredients, essential oils, and a mix of aroma compounds and natural ingredients such as essential oils, extracts, and resins.

[0050] The fragrance oil may be 0.01% to 80% w/w of the long-lasting fragrance composition. In an aspect of the invention, the fragrance oil may be 1% to 30% w/w of the long-lasting fragrance composition.

[0051] A gelator (gelling agent) according to the present invention may be a molecule from the class of Low Molecular Weight Gelators (LMWG) compounds such as long chain (>16CH.sub.2) n-alkanes, hydroxyalkanoic acids as hydroxy-octadecanoyl, hydroxy-hexadecanoyl, etc., dihydroxyalkanoic acids, dicarboxylic acids, fatty acids alkyl ester with alkyl chain length >20 CH2 groups, hydroxyalkanoic alcohols, steroid derivatives such as glycyrrhizic acid, caffeine, anthryl derivatives, molecules containing steroidal and condensed aromatic rings, dendrimers n-alkanes, oligo(p-phenylenevinylene), dipyridylurea—carboxylic acid combination, diamine linked Dendron, amino acid-based gelators such as dibutyl ethylhexanoyl glutamide and dibutyl lauroyl monoglycerol, 2-glycerol, glycerate, glyceryl ether, monoethanolamide, diethanolamide, glutamide, carbohydrate derived gelators, peptide-based derivatives, and others. Preferred gelators are organogelators. Preferred gelators are amino acid-based gelators and hydroxyfatty acid gelators.

[0052] A volatile solvent according to the present invention has an evaporation rate or vapor pressure higher than that of water. The vapor pressure of water at 35° C. is 5.62 kPa. In one aspect of the present invention, the volatile solvent is ethanol.

[0053] A long-lasting fragrance of the present invention may include a hydrotrope or hydrotropic salt (e.g., sodium salicylate). Suitable ranges of a hydrotrope or hydrotropic salt are 0 to 5% w/w of the long-lasting fragrance, or 0.01% to 2% w/w of the long-lasting fragrance.

[0054] A long-lasting fragrance composition of the present invention may include an osmolyte. An osmolyte may be a slightly water soluble compound such as a humectant (e.g., glycols such as dipropylene glycol, butylene glycol, propylene glycol, glycerine, pentanediols, hexanediols, propanediols, butanediols, xylitol), an emollient, a natural osmolyte (ectoine), and a biopolymer. The osmolyte may be 0 to 1% or 0.01% to 0.5% w/w of the long-lasting fragrance.

Consumer Products:

[0055] Leave-on volatile solvent containing consumer products such as Parfum, Eau de Toilette, Eau deparfum, Body mist, body spray, Body splash, Hair mist, air care spray, Hair Leave-on products, Fabric refreshers, Deodorant, etc.

[0056] The leave-on volatile solvent containing consumer product may further include a dye, a UV filters, an antioxidant, a quencher, a chelating agent, a solubilizer, a moisturizer, a humectant, an anti-aging active, a soothing agent, an anti-pollution active, emollient or a combination thereof.

EXAMPLES

[0057] The following examples illustrate, but do not limit, the present invention.

Example 1: Reference EDT (EDT0)

[0058] a) Formulation and Process

[0059] A reference Eau De Toilette (EDT) formulation was prepared and used as a reference to evaluate fragrance performance. Water was added to ethanol as set forth in Table 1. After stirring, fragrance was added to this solution. The final mixture was stirred until homogeneous.

TABLE-US-00001 TABLE 1 Ingredients Amount (% wt) Function Ethanol .sup.1) 70 Solvent Water 20 Solvent Fragrance 10 Fragrance .sup.1) Ethanol Absolute anhydrous; origin: Carlo Erba.

Example 2: EDT Containing Phytantriol (EDT1)

[0060] b) Formulation and Process

[0061] The amphiphilic oil-soluble compound phytantriol was dissolved in ethanol. Water was added to this solution. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 2.

TABLE-US-00002 TABLE 2 Ingredients Amount (% wt) Function Ethanol.sup.1) 70 Solvent Water 19 Solvent Phytantriol.sup.2) 1 Amphiphilic oil soluble compound Fragrance 10 Fragrance .sup.1)Ethanol Absolute anhydrous; product of Carlo Erba. .sup.2)3,7,11,15-Tetramethylhexadecane-1,2,3-triol (Phytantriol) product of DSM.

Example 3: EDT Containing Phytantriol and Glycyrrhizic Acid Ammonium Salt (AGA) (EDT2)

[0062] a) Formulation and Process

[0063] Phytantriol and Glycyrrhizic acid ammonium salt were mixed in ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 3.

TABLE-US-00003 TABLE 3 Ingredients Amount (% wt) Function Ethanol.sup.1) 70 Solvent Water 19 Solvent Phytantriol.sup.2) 0.75 Amphiphilic oil soluble compound Glycyrrhizic acid 0.25 Gelator ammonium salt.sup.3) Fragrance 10 Fragrance .sup.1)Ethanol Absolute anhydrous; origin: Carlo Erba. .sup.2)Phytantriol; origin: DSM. .sup.3)Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice); origin: Sigma-Aldrich.

Example 4: EDT Containing Phytantriol and Caffeine (EDT3)

[0064] a) Formulation and Process

[0065] Phytantriol and caffeine were mixed in ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 4.

TABLE-US-00004 TABLE 4 Ingredients Amount (% wt) Function Ethanol.sup.1) 70 Solvent Water 19 Solvent Phytantriol.sup.2) 0.75 Amphiphilic oil soluble compound Caffeine.sup.3) 0.25 Gelator Fragrance 10 Fragrance .sup.1)Ethanol Absolute anhydrous; origin: Carlo Erba. .sup.2)Phytantriol; origin: DSM. .sup.3)Caffeine; origin: Fluka Analytical.

Example 5: EDT Containing Phytantriol and Sodium Salicylate (EDT4)

[0066] a) Process

[0067] Phytantriol and sodium salicylate were mixed in Ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 5.

TABLE-US-00005 TABLE 5 Ingredients Amount (% wt) Function Ethanol.sup.1) 70 Solvent Water 18.8 Solvent Phytantriol.sup.2) 1 Amphiphilic oil soluble compound Sodium Salicylate.sup.3) 0.2 Hydrotropic salt Fragrance 10 Fragrance .sup.1)Ethanol Absolute anhydrous; origin: Carlo Erba. .sup.2)Phytantriol; origin: DSM. .sup.3)Sodium Salicylate, 99%; origin: Alfa Aesar.

Example 6: EDT Containing Glycerol Monooleate

[0068] Glycerol monooleate (GMO) was mixed in ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 6.

TABLE-US-00006 TABLE 6 Ingredients Amount (% wt) Function Ethanol.sup.1) 72 Solvent Water 15 Solvent Glycerol monooleate.sup.2) 3 Structuring amphiphilic oil soluble compound Fragrance 10 Fragrance .sup.1)Ethanol Absolute anhydrous; origin: Carlo Erba. .sup.2)Glycerol monooleate; origin: Dupont.

Example 7: EDT Containing Isocetyl Alcohol

[0069] Isocetyl alcohol (ICA) was mixed in ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 7.

TABLE-US-00007 TABLE 7 Ingredients Amount (% wt) Function Ethanol.sup.1) 70 Solvent Water 15 Solvent Isocetyl alcohol.sup.2)  5 Modulator Fragrance 10 Fragrance .sup.1)Ethanol Absolute anhydrous; origin: Carlo Erba. .sup.2)Isocetyl alcohol; origin: Ashland.

Example 8: EDT Containing Glycerol Monooleate and Isocetyl Alcohol

[0070] Glycerol monooleate (GMO) and isocetyl alcohol (ICA) were mixed in Ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 8.

TABLE-US-00008 TABLE 8 Ingredients Amount (% wt) Function Ethanol.sup.1) 67 Solvent Water 15 Solvent Glycerol monooleate.sup.2) 3 Amphiphilic oil soluble compound Isocetyl alcohol.sup.3) 5 Modulator Fragrance 10 Fragrance .sup.1)Ethanol Absolute anhydrous; origin: Carlo Erba. .sup.2)Glycerol monooleate; origin: Dupont. .sup.3)Isocetyl alcohol; origin: Ashland.

Example 9: EDT Containing Glycerol Monooleate, Nerolidol and Dibutyl Ethylhexanoyl Glutamide

[0071] Glycerol monooleate (GMO), nerolidol and dibutyl ethylhexanoyl glutamide (EB-21) were mixed in ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 9.

TABLE-US-00009 TABLE 9 Ingredients Amount (% wt) Function Ethanol 70.70 Solvent Water 15 Solvent Glycerol monooleate 3 Amphiphilic oil soluble compound Nerolidol 1 Modulator Dibutyl Ethylhexanoyl 0.3 Gelator Glutamide Fragrance 10 Fragrance

Example 10: EDT Containing Glycerol Monooleate, Nerolidol, Polymethylol and Dibutyl Ethylhexanoyl Glutamide

[0072] Glycerol monooleate (GMO), nerolidol, polymethylol and dibutyl ethylhexanoyl glutamide (EB-21) were mixed in ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 10.

TABLE-US-00010 TABLE 10 Ingredients Amount (% wt) Function Ethanol 69.70 Solvent Water 15 Solvent Glycerol monooleate 3 Amphiphilic oil soluble compound Nerolidol 1 Modulator Polymethylol 1 Modulator Dibutyl Ethylhexanoyl 0.3 Gelator Glutamide Fragrance 10 Fragrance

Example 11: EDT Containing Glycerol Monooleate, Nerolidol, Polymethylol and Dibutyl Ethylhexanoyl Glutamide

[0073] Glycerol monooleate (GMO), polymethylol and dibutyl ethylhexanoyl glutamide (EB-21) were mixed in Ethanol. To this solution was added water. After stirring, fragrance was added to this mixture. The final solution was stirred until homogeneous. See Table 11.

TABLE-US-00011 TABLE 11 Ingredients Amount (% wt) Function Ethanol 69.70 Solvent Water 15 Solvent Glycerol monooleate 3 Amphiphilic oil soluble compound Polymethylol 2 Modulator Dibutyl Ethylhexanoyl 0.3 Gelator Glutamide Fragrance 10 Fragrance

Example 12—Performance

a) Process

[0074] Evaporation kinetic studies were performed. The test and reference compositions were deposited on the glass bottom of head-space vials and were evaporated after 2, 4, 6 or sometimes 24 hours at 32° C. (corresponding to the skin temperature) under agitation. At a given moment, the vials were closed and left for saturation of the head-space at 32° C. Small amounts of the saturated head-space vapors were injected in GC-MS instrument and the vapor composition was analyzed.

[0075] Sample Preparation

[0076] For kinetics analysis, six identical samples were prepared at the same time. For each sample, a piece (1×1 cm) of blotter (Scentis, 160 mm×20 mm) was introduced at the bottom of a 20 mL headspace-GCMS screw vial (BGB Analytik, 180420). 10 μL of an EDT-type sample was deposited on the blotter with a micropipette. All vials were closed after the required evaporation time (0, 2, 4 or 6 h).

[0077] A CTC PAL was installed on the GC-MS (6890 series GC system & 5973 network MS) for sample injection. This CTC PAL was equipped with a 1 mL syringe. 1 mL of headspace gas was taken from the samples and injected into a GC-MS instrument. Before each injection, samples were agitated at 32° C. for 30 min by the composer of the GCMS.

[0078] GC Parameters

[0079] An Agilent GC was used with a split/splitless inlet and Helium as carrier gas. A septum BTO was installed (Bleed & Temp Optimized septa, 11 mm/Agilent 5183-4757) and the liner was heated at 250° C. (liner, splitless, single traper, deactivated/Agilent 5181-3316). The samples were analyzed with a split ratio 5:1.

[0080] A non-polar column was mounted in the oven. (Agilent_190915-433_HP-5MS—Fused silica capillary column-bounded, PDMS ((5%-Phenyl)-methylpolysiloxane—Length 30 m, diameter 250 μm, Film thickness 0.25 μm). The analyses were done at constant flow with an initial flow at 1 mL/min (corresponding to an average velocity of 36 cm/s). The oven program started at 40° C. The temperature rose to 150° C. with a temperature ramp of 20° C./min, and then rose to 250° C. with a temperature ramp of 50° C./min. The oven held the temperature at 250° C. for one minute.

[0081] MS Parameters—SIM Method

[0082] A SIM method was used to determine fragranced ingredients in headspace gas. No solvent delay was used. The mass were analyzed between 35 and 320 with a threshold at 25.

b) Results

[0083] 1) Single Perfumery Ingredient Performance

[0084] The perfumery ingredient Styrallyl acetate (provided by Firmenich SA and having a volatility equal to 1320.4 μg/L air) was solubilized in formulation EdT1-4 and deposited according to “Sample preparation” above. Performance at different times during the evaporation process is shown in FIG. 1 as value relative to the intensity of the reference EdT formulation. The results demonstrate increased fragrance performance from formulations EDT1 to 4 after 2 and, even greater, after 4 hours of evaporation compared to the reference sample (EDT0) corresponding to 1.

[0085] 2) Model Perfumery Mixture Performance

Test 1:

[0086] Model fragrance A, shown in Table 12, was solubilized in EDT2 and deposited as explained in “Sample preparation”. The intensity of the perfumery ingredients, was followed at different times during the evaporation process. The performance of the perfumery ingredients 6 hours after the deposition is shown in FIG. 2 as value relative to the intensity of the reference EdT formulation. The values >1 mean that the intensity was greater than the reference EdT0.

TABLE-US-00012 TABLE 12 Fragrance A Fragrance Ingredient % wt Volatility (μg/L air) Benzyl Acetate 6 2016.3 Dihydromyrcenol Pur 2 252.3 Citronellol BJ 2 189.61 Florol Neo 12 176.08 Geraniol Pur 10 148.42 Hedione 10 19.33 Phenethylol Ord 20 12.78 Iso E Super 2 10.05 Helvetolide 4 6.68 Muscenone delta 1 5.24 Habanolide 6 0.9053 Dipropylene Glycol* 25

Test 2:

[0087]

TABLE-US-00013 TABLE 13 Research Accord HT1 (RAHT1) used in this experiment consists of below 44 ingredients ranging from high volatility to low volatility ingredients at equal concentrations. VOLATILITY LOG Compound Name μg/l air Po/w PIPOL ACETATE 5880 2.62 ALLYL CAPROATE 2750 3.62 ZESTOVER 2060 2.34 3-Cyclohexene-1-carboxylic 1880 3.63 acid, 2,6,6-trimethyl-, methyl ester OXANE 1840 3.11 PIPOL BUTYRATE 1670 3.59 METHYL BENZOATE 1610 2.1 ROMASCONE 1460 3.93 ETHYL BENZOATE 1290 2.51 DIMETOL 1150 3.24 PIPOL ISOBUTYRATE 1070 3.57 Propyl (2S)-2-(1,1- 995 3.17 dimethylpropoxy)-propanoate GALBANOLENE SUPER 994 5.68 SAFRANAL 918 2.57 LINALOL BJ 899 2.94 ISOBORNYL ACETATE PUR 886 4.13 MENTHONE PURIFIED 839 3.46 ALLYL HEPTANOATE 822 4.16 CITRONELLALCP 771 2.91 TRANS DECENAL 691 3.73 VIOLETTYNE 10 MIP(1,3- 677 5.11 Undecadien-5-yne) KOAVONE 659 3.71 ESTRAGOLE 587 3.33 PHENYLETHYL FORMATE 568 1.9 ETHYL LINALOL 343 3.54 DELPHONE 235 3.62 DELTA DAM ASCON E 151 4.13 CITRONELLYL ACETATE 129 4.22 NERYL ACETATE BJF 123 3.81 Methyl Octyl Carbinol (OCM) 91.8 3.51 GERANYL ACETATE EXTRA 85.2 3.99 ALLYL CYCLOHEXYLPROPIONATE 44 4.51 INDOLE 33.1 1.74 MAGNOLAN 32.5 2.44 GAMMA NONALACTONE 27.4 2.45 CYCLOSAL 24.2 3.59 DECAL 9.63 3.02 UNDECALACTONE DELTA 4.64 3 5-Cyclopentadecen-1-one, 3-methyl 2.49 5.98 Naphtho[2,1-b]furan, dodecahydro- 2.19 6.88 3a,6,6,9a-tetramethyl-, [3aR VANILLIN PERF 2.19 0.72 (+)-cis-METHYL 1.63 2.95 DIHYDROJASMONATE COUMARIN 0.51 1.35 BENZYL SALICYLATE 0.26 4.26

[0088] Tables 14A-C. Below are the three formulas tested—model perfume (RAHT1 in EDT) as control, technology 1 as model perfume with 5% Phytantriol 2% Polymethylol 0.3% EB-21 gelling agent and technology 2 as model perfume with 5% Phytantriol 2% Schercemol 0.3% EB-21 gelling agent.

TABLE-US-00014 A Model perfume as Quantity Quantity control (% wt) (g) Research Accord HT1  10.00%  1 EtOH 40B  80.00%  8 H2O  10.00%  1 Total 100.00% 10

TABLE-US-00015 C Technology 2: Model perfume + 5% Phytantriol + 2% Schercemol + 0.3% EB-21 Quantity Quantity (% wt) (g) Research Accord HT1  10.00% 1 Phytantriol   5.00% 0.5 EB-21   0.30% 0.03 Schercemol   2.00% 0.2 EtOH 40B  67.70% 6.77 H2O  15.00% 1.5 Total 100.00% 10

TABLE-US-00016 B Technology 1: Model perfume + 5% Phytantriol + 2% Polymethylol + 0.3% EB-21 Quantity Quantity (% wt) (g) Research Accord HT1  10.00% 1 Phytantriol   5.00% 0.5 EB-21   0.30% 0.03 Polymethylol   2.00% 0.2 EtOH 40B  67.70% 6.77 H2O  15.00% 1.5 Total 100.00% 10

Method Used as Follows:

[0089] Evaporations were done in Tzero lids. Prazitherm PZ72 slide warmer was pre-heated to 32 degrees Celsius for 30 minutes. Each crucible was placed on the precision hotplate. Using an adjustable volume pipette, 10 μL of fragrance was dosed directly to the center of the crucible and evaporated at 32° C. for 1 hour, 2 hours, 4 hours and 6 hours on the precision hotplate. A duplicate set was performed for each sample and each condition tested. When time points were reached, each crucible was placed in a 2-mL Agilent GC vial (Agilent 5183-2068) and 600 μL ethanol was added to stop the evaporation. Vials were closed and mixed by shaking for at least 1 minute. Samples were analyzed by GC-MS direct injection methodology. See FIGS. 8 to 17.

[0090] 3) Effect of Amphiphilic Oil-Soluble Compound Concentration

[0091] The effect of the amphiphilic oil-soluble compound concentration on the retention of fragrance ingredients is shown in FIG. 3. Fragrance A was solubilized at 10% wt in a mixture of ethanol, water, phytantriol at different phytantriol concentrations. The water concentration was kept constant and equal to 20% wt. Increasing phytantriol concentration lead to better results; after 6 hours of evaporation, the highly volatile benzyl acetate and dihydromyrcenol had higher concentrations in the head space in comparison to the reference sample.

[0092] 4) Sensory Evaluation in the Presence of Phytantriol or Glycerol Monooleate or Mixtures

[0093] A sensory evaluation of fragrance intensity was performed. 20 μl of formulation was deposited on glass plates, which were maintained at 32° C. on a heated platform. At different times (t=0 min (Fresh), 2 hours, 4 hours, 5 hours and 6 hours), the randomized glass plates were evaluated by 15 panelists.

[0094] A 3-Alternative Forced Choice (or 3-AFC) test was used. For each time point, panelists were presented with 3 samples, two of which were the fragrance (SP), and one in which the fragrance was in accordance with the present invention. Panelists indicated the sample(s) that were higher in terms of overall intensity.

[0095] Hypothesis: [0096] H0: The two samples are not different. [0097] H1: The sample with technology is more intense than the sample without it, in terms of overall intensity.

[0098] Associated Risks: [0099] H0 rejected=a risk: [0100] Risk associated with a false alarm, concluding that products differ when in fact they do not.

[0101] Data was analyzed using the binomial statistic.

[0102] Data Interpretation: [0103] If the p-value obtained for α≤0.05, then the sample with technology was more intense in overall intensity than the sample without it [0104] If the p-value obtained for α is 0.05<α≤0.10, then a trend difference was determined. [0105] If the p-value obtained for α>0.10, the samples were not significantly different.

[0106] The fragrance SP contained 44% of fragrance ingredients with log P<4 (high volatility).

[0107] The results of the sensory panel presented in Table 15 shows the higher performance of the formulation according to the present invention after 4 hours of evaporation in the presence of 10% phytantriol, and after 2 hours of evaporation in the presence of 10% GMO.

TABLE-US-00017 TABLE 15 Nb of pane- p-value Samples lists Fresh 2 h 4 h 5 h 6 h SP @10% (ref) 16 0.4531 0.1265 0.0008 0.0008 0.0500 vs SP @ 10% + 10% Phytantriol SP @10% (ref) 16 0.2630 0.0160 0.0040 0.0040 0.0160 vs SP @ 10% + 10% GMO

[0108] The performance of mixtures of GMO with ICA was studied.

[0109] Sensory panels were performed in order to compare:

[0110] Fragrance SP in EDT without and with 3% GMO (Table 6),

[0111] Fragrance SP in EDT without and with 5% ICA (Table 7),

[0112] Fragrance SP in EDT without and with 3% GMO+5% ICA (Table 8).

[0113] The results presented in FIG. 4 show:

[0114] with 3% GMO: no difference,

[0115] with 5% ICA: significant difference at 4 and 5 hours,

[0116] with 3% GMO+5% ICA: significant difference at 5 and 6 hours.

[0117] There was a higher performance of the formulation containing the mixture of GMO-ICA after 5 hours of evaporation.

[0118] The same experiment was done with a mixture of GMO and Hedione.

[0119] Sensory panels were performed in order to compare:

[0120] Fragrance SP in EDT without and with 3% GMO (Table 6)

[0121] Fragrance SP in EDT without and with 5% Hedione (Table 7).

[0122] Fragrance SP in EDT without and with 3% GMO+5% Hedione (Table 8)

[0123] The results presented in FIG. 5 show:

[0124] with 3% GMO: no difference,

[0125] with 5% Hedione: significant difference from 2 to 4 hours,

[0126] with 3% GMO+5% Hedione: significant difference from 2 to 6 hours.

[0127] There was a higher performance of the formulation containing the mixture GMO-Hedione after 2 hours of evaporation.

[0128] 5) Examples of Synergistic Mixtures

[0129] Mixtures of the amphiphilic oil-soluble compound (phytantriol) and a fixative (ICA) or a gelator (EB-21) were prepared and integrated in ethanol-water solutions having the proportions shown in Table 2. The performance of two highly volatile fragrance ingredients: benzyl acetate and dihydromyrcenol, were followed after evaporation at 2, 4 and 6 hours and compared to the performance of the reference sample EDT0 (value 1). The intensity of the fragranced ingredients after 6 hours of evaporation was significantly higher in presence of phytantriol and the mixture of phytantriol and gelator. See FIG. 6.

[0130] Mixtures of (A) benzyl acetate with 10% phytantriol, and benzyl acetate with 10% phytantriol and β-cyclodextrin (CD); and (B) dihydromyrcenol with 10% phytantriol, and dihydromyrcenol with 10% phytantriol and CD were prepared and integrated in ethanol-water solutions having the proportions mentioned in Table 2. The performance of the two highly volatile fragrance ingredients: benzyl acetate and dihydromyrcenol, were followed after evaporation at 2, 4 and 6 hours. The intensity was greater for the mixtures containing CD. See FIG. 7.

[0131] Mixtures of the fragrances SP and LS with GMO combined with a modulator and a gelator were prepared and integrated in ethanol-water solutions having the proportions mentioned in Table 9, 10 and 11. At different moments t=0 min (Fresh), 4 hours and 6 hours, the randomized glass plates were evaluated by 7 panelists. The results presented in the Table 16 show higher performance of the formulations according to the present invention compared to control after 4 hours of evaporation for both fragrances SP and LS.

[0132] The combination 3% GMO, 1% Nerolidol and 0.3% EB-21 was the most efficient as it allowed higher performance after 4 hours and 6 hours for both fragrances SP and LS.

[0133] Lower p-values on fragrance LS compared to SP show a better performance of LS, which may be linked to its fragrance architecture that contains higher amount of heart notes.

TABLE-US-00018 TABLE 16 Fragrance p-value Fragrance architecture Samples N* Fresh 4 h 6 h SP 28.5% > 0.08 torr SP @10% (ref) 7 1.0000 0.1733 0.0453 16.5% 0.0008-0.08 torr vs SP @10% + [45% > 0.0008 Torr] 3% GMO + 1% 55% < 0.0008 torr Nerolidol + 0.3% EB-21 SP 28.5% > 0.08 torr SP @10% (ref) 7 0.7366 0.0453 0.7366 16.5% 0.0008-0.08 torr vs SP @10% + [45% > 0.0008 Torr] 3% GMO + 1% 55% < 0.0008 torr Nerolidol + 1% Polymethylol + 0.3% EB-21 SP 28.5% > 0.08 torr SP @10% (ref) 7 0.4294 0.0453 0.1733 16.5% 0.0008-0.08 torr vs SP @10% + [45% > 0.0008 Torr] 3% GMO + 2% 55% < 0.0008 torr Polymethylol + 0.3% EB-21 LS 14.5% > 0.08 torr LS @10% (ref) 7 0.7366 0.0453 0.0069 37.5% 0.0008-0.08 torr vs SP @10% + [52% > 0.0008 Torr] 3% GMO + 1% 48% < 0.0008 torr Nerolidol + 0.3% EB-21 LS 14.5% > 0.08 torr LS @10% (ref) 0.4294 0.0453 0.0453 37.5% 0.0008-0.08 torr vs LS @10% + [52% > 0.0008 Torr] 3% GMO + 1% 48% < 0.0008 torr Nerolidol + 1% Polymethylol + 0.3% EB-21 *N = Number of panelists

Influence of Fragrance Construction

[0134] Sensory panels evaluated model fragrances having different constructions which vary from a typical pyramid architecture (middle volatility components present in a greater amount than the low and high volatility components) were tested in sensory panel in the presence of GMO solutions.

[0135] The results presented on Table 17 show that performance with GMO was dependent on the fragrance construction based on the volatility of the perfume's raw materials

[0136] The results shown below were based on perceived intensity of a panel for Fragrance at 10% in presence of 3% GMO VS Fragrance at 10% alone. The improved performance was noted with % of correct answers >55% with included significance listed (p-value)

TABLE-US-00019 TABLE 17 p-value Fragrance Samples N Fresh 2 h 4 h 5 h 6 h A 10.7% > 0.08 torr 20 0.9997 0.3385   0.9824   0.9396   0.3385 22.3% 0.0008-0.08 torr [33% > 0.0008 Torr] 67% < 0.0008 torr B 53.7% > 0.08 torr 15 0.0085 0.3816   0.2030   0.0018 <0.0001 21.3% 0.0008-0.08 torr [75% > 0.0008 torr] 25% < 0.0008 torr C 43.7% > 0.08 torr 17 0.0019 0.3261 <0.0001   0.0019   0.0003 16.3% 0.0008-0.08 torr 60% > 0.0008 torr] 40% < 0.0008 torr D 29.7% > 0.08 torr 10 0.7009 0.0004 <0.0001 <0.0001 <0.0001 40.3% 0.0008-0.08 torr [70% > 0.0008 torr] 30% < 0.0008 torr

[0137] Perfumery rules impart extra-improved performance and include a fragrance component as follows: [0138] A volatility component in an amount from 35% to 100 wt % of the fragrance component, comprising at least one perfume raw material having a first vapor pressure greater than 0.0008 Torr at 22° C.; [0139] And, within the perfume constructions above: [0140] Construction 1—A volatility component from 40 to 100 wt % of the fragrance component comprising at least one perfume raw material having a first vapor pressure greater than 0.08 torr and optionally, a second at least one perfume raw material having a first vapor pressure greater than 0.08 Torr at 22° C.; [0141] Construction 2—A volatility component in an amount from 0.08 to 85 wt % of the fragrance component, comprising a first at least one perfume raw material having a first vapor pressure range of 0.0008 to 0.08 Torr at 22° C.; and, optionally, a second at least one perfume raw material having a first vapor pressure range of 0.0008 to 0.08 Torr at 22° C.;

c) Conclusion

[0142] The comparison of these different evaporation kinetics shows that formulations of the present invention have higher fragrance retention than a standard Eau de toilette composition. The fragrance retention is significant in the EdT formulations containing amphiphilic oil-soluble compounds of the present invention (phytantriol) and low molecular weight gelators. The long-lasting performance of the invention against the standard EdT formulation was confirmed 4-6 h after the deposition. Synergistic mixtures were discovered surprisingly providing better fragrance retention.

[0143] Publications cited throughout this document are hereby incorporated by reference in their entirety. Although the various aspects of the invention have been illustrated above by reference to examples and preferred embodiments, it will be appreciated that the scope of the invention is defined not by the foregoing description but by the following claims properly construed under principles of patent law.