Chemistry Kits

Abstract

The invention consists of an assembly of a reaction block a holder that contains arrays of vials. The vials can contain one or more of reagents, catalysts, and solvents for carrying out the series of chemical reactions.

Claims

1. An assembly for conducting a series of chemical reactions, comprising: a) a thermally-conductive reaction block comprising at least two arrays of wells for holding reaction vessels for holding one or more of reagents, catalysts, and solvents for carrying out the series of chemical reactions, wherein the reaction vessels have different heights and the wells of the arrays have different depths so that the reaction vessels, when inserted into the wells, present a uniform height at their tops; b) a holder for positioning the reaction vessels in the arrays of wells; c) instructions on the holder related to carrying out the series of chemical reactions in the reaction vessels.

2. The assembly of claim 1, wherein the holder denotes numbered or lettered positions for the reaction vessels.

3. The assembly of claim 1, wherein the reaction block has two arrays of wells.

4. The assembly of claim 1, wherein the reaction block has three arrays of wells.

5. The assembly of claim 1, wherein the holder is formed of paper, cardboard, plastic, or resin.

6. The assembly of claim 1, wherein the reaction block is formed of metal.

6. The assembly of claim 6, wherein the reaction block is formed of aluminum.

8. The assembly of claim 1, wherein the wells have different diameters.

9. The assembly of claim 1, further comprising a cover coupled to the reaction block.

10. The assembly of claim 9, wherein the cover is coupled to the reaction block with a clip.

11. The assembly of claim 1, wherein the cover holds reaction vessels in the wells of the reaction block.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0008] The foregoing will be apparent from the following more particular description of example embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating embodiments of the present invention.

[0009] FIG. 1 is a front elevated view of one arrangement of an assembly for conducting a series of chemical reactions.

[0010] FIG. 2 is a front side view of one arrangement of an assembly for conducting a conducting a series of chemical reactions.

[0011] FIG. 3 is an example of a holder for use in an assembly for conducting a conducting a series of chemical reactions.

DETAILED DESCRIPTION OF THE INVENTION

[0012] A description of example embodiments of the invention follows.

[0013] An embodiment of the invention consists of an assembly that allows the survey of a type of chemistry. The survey can be performed using a plurality of reagents, catalysts and solvents. The plurality of reagents, solvents and/or catalysts are designed to survey and/or optimize a specific type of chemistry such as amide coupling, cross-coupling palladium chemistry, and others.

[0014] As illustrated in FIGS. 1 and 2, a holder 2 is placed on top of a reaction block 4. Reaction vessels 7A, 7B, and 7C can be placed within the wells 8A, 8B and 8C of the reaction block 4. A cover 1 has openings 9A, 9B and 9C aligned with the wells 8A, 8B and 8C of the reaction block 4. The cover 1 can be maintained on the reaction block 4 using a clip 3, which is attached to the cover and the block. As illustrated in FIG. 2, reaction vessels 7A-C are nested in the wells 8A-C of reaction block 4. A cover 1 can be applied to the top of the reaction vessels 7A-C to maintain the reaction vessels 7A-C within the reaction block 4. The wells 8A-C in the reaction block 4 are designed to allow the top of each reaction vessel 7A-C to present a uniform height, even where the reaction vessels 7A-C have different dimensions. The cover 1 has holes that allow a needle 6 to pierce the septum cap of each reaction vessel 7A-C nested in a well 8A-C of the reaction block 4. The cover 1 can be locked onto the reaction block using a clip 3.

[0015] FIG. 3 is an example of a holder 2 that has openings 10 for sixteen reaction vessels (not shown). A protocol is written on the holder 2, and the positions of the openings 10 for the reactions vessels align with the wells 7B of the reaction block 4.

[0016] This assembly can contain one or more of reagents, catalysts, and solvents, typically inside the reaction vessels, in exact quantities to perform each individual reaction. The reaction conditions described on the holder 2 are designed to cover a type of chemistry and find an appropriate reaction condition that provides the best conversion to the desired product.

[0017] Another embodiment of the invention is a plurality of reaction vessels containing the exact amount of reagents for evaluating a specific chemistry in an array of reaction vessels. Optionally, the precise amounts of solvent necessary to dissolve the substrates can also be included. This plurality of reaction vessels can be packaged with, or optionally within, a holder 2 that fits on top of the reaction block 4. The instructions on holder 2 facilitates the performance of the experiment by describing the successive protocol steps.

[0018] Another embodiment of the invention is an assembly of a reaction block that contain up to (24) 6 mm11 mm vials, up to (32) 8 mm6 mm vials and up to (4) 4 mm15 mm vials, a holder that that contain up to (24) 6 mm11 mm vials, up to (32) 8 mm6 mm vials and up to (4) 4 mm15 mm vials and a cover that contains openings that provide access to each opening in the holder and each well in the reaction block.

[0019] While this invention has been particularly shown and described with references to example embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.