A LIQUID ANTIMICROBIAL COMPOSITION

Abstract

A valve structuring designed for use in all water installations, water inlets for houses, kitchen installations and embedded shower filters as a stop valve, in the areas to perform on-off control, in faucets with the purpose of providing water savings and to use in domestic and industrial type kitchen faucets as a stop valve. The valve is designed for use as an on-off valve in air installations that operate with air.

Claims

1. A liquid antimicrobial composition for use in the disinfection of the skin of a human or an animal with a pH no less than 5.5 and comprising a cationic, cell membrane-disrupting biocide being any or a combination of chlorhexidine, a polymeric biguanide, octenidine dihydrochloride and a quaternary ammonium compound and a cationic dendrimer capable of inhibiting an efflux pump mechanism of said cell membrane and being any of a generation 0 to generation 3 dendrimer or a combination of same and any or a combination of quaternary ammonium functionalised poly(propylene imine), polylysine, dendrimers with surface groups based on a sugar and polyimide amine (PAMAM) dendrimers.

2. (canceled)

3. A composition as claimed in claim 1, wherein the cationic, cell membrane-disrupting biocide comprises chlorhexidine in the form of a gluconate or of an acetate salt.

4. A composition as claimed in claim 1, wherein the cationic, cell membrane-disrupting biocide is present in a concentration between 0.25% and 6.00% w/v inclusive.

5. (canceled)

6. (canceled)

7. A composition as claimed claim 1, wherein the dendrimer is poly(propylene imine).

8. A composition as claimed in claim 1, wherein the dendrimer comprises between 0.01% w/v and 2% w/v inclusive of the composition.

9. A composition as claimed in claim 1, additionally comprising a surfactant.

10. A composition as claimed in claim 9, wherein the surfactant is a poloxamer tri block copolymer surfactant.

11. A composition as claimed in claim 9, wherein the surfactant has a hydrophilic-lipophilic balance (HLB) with a value between 10 and 17 inclusive.

12. A composition as claimed in claim 9, wherein the surfactant is present at a concentration at least 10% below its critical micelle concentration.

13. A composition as claimed in claim 9, wherein the surfactant comprises between 0.05% w/v and to 5.00% w/v inclusive of the composition.

14. A composition as claimed in claim 1, additionally comprising a chelating agent.

15. A composition as claimed in claim 14, wherein the chelating agent comprises any or a combination of etidronic acid (1-hydroxyethane 1,1-diphosphonic acid (HEDP)), ethylene diamine, di or tetra acetate, a phosphonate and a nitriloacetate.

16. A composition as claimed in claim 14, wherein the chelating agent comprises between 0.05% w/v and 1.00% w/v inclusive of the composition.

17. A composition as claimed in claim 1, additionally comprising an essential oil or essential oil component in combination with a solvent for same.

18. A composition as claimed in claim 17, wherein the solvent is ethanol or polyethylene glycol.

19. A composition as claimed in claim 17, wherein the essential oil or essential oil component comprises any or a combination of berberine, helichrysum italicum, geraniol, a pinene, alpha zingiberine, a terpene and tea tree oil.

20. A composition as claimed in claim 17, wherein the essential oil or essential oil component comprises between 0.01% w/v and 1.00% w/v inclusive of the composition.

21. A composition as claimed in claim 1, in the form of an aqueous or aqueous alcohol solution or dispersion.

22. (canceled)

23. A composition as claimed in claim 1, in combination with a wipe, a sponge or a shampoo cap.

24. (canceled)

25. (canceled)

26. A method of disinfecting the skin of a human or an animal by the topical application thereto of a liquid antimicrobial composition with a pH no less than 5.5 and comprising a cationic, cell membrane-disrupting biocide being any or a combination of chlorhexidine, a polymeric biguanide, octenidine dihydrochloride and a quaternary ammonium compound, and a cationic dendrimer capable of inhibiting an efflux pump mechanism of said cell membrane and being any of a generation 0 to generation 3 dendrimer or a combination of same and any or a combination of quaternary ammonium functionalised poly(propylene imine), polylysine, dendrimers with surface groups based on a sugar and polyimide amine (PAMAM) dendrimers.

Description

EXAMPLE 1

[0045]

TABLE-US-00005 Chlorhexidine gluconate 2.00% w/v PEO-PPO-PEO block copolymer 1.00% w/v Polypropylenimine (PPI) dendrimer 0.01% w/v Disodium ethylenediaminetetraacetic acid 0.05% w/v (Disodium EDTA) Water to 100%

EXAMPLE 2

[0046]

TABLE-US-00006 Chlorhexidine gluconate 2.00% w/v Polypropylenimine (PPI) dendrimer 1.00% w/v PEO-PPO diblock copolymer 0.05% w/v HEDP 0.02% Ethanol 70% Water to 100%

EXAMPLE 3

[0047]

TABLE-US-00007 Chlorhexidine gluconate 4.00% w/v Geraniol 1.00% w/v Polylysine dendrimer 0.05% w/v Polyhexamethylene biguanide hydrochloride 0.50% w/v Phenoxyethanol 0.20% w/v PEG 40 0.50% w/v Water to 100%

EXAMPLE 4

[0048]

TABLE-US-00008 Benzalkonium chloride 1.00% w/v Cetylpyridinium chloride 0.50% w/v Cationic dendrimer 1.00% w/v Capryl glucoside surfactant 0.05% w/v PEO/PPO block copolymer surfactant 0.50% w/v Water to 100%

EXAMPLE 5

[0049]

TABLE-US-00009 Octenidine dihydrochloride 2.00% w/v PAMAM dendrimer 1.00% w/v Polysorbate 20 0.50% w/v Glycerine 1.00% w/v Aloe vera 0.50% w/v Essential oil based fragrance 0.10% w/v EDTA di sodium salt 0.05% w/c Water to 100%

EXAMPLE 6

[0050]

TABLE-US-00010 Chorhexidine gluconate 2.5% w/v Isopropyl alcohol 70.0% w/v Polypropyleneimine dendrimer 1.5% w/v Phenoxyethanol 0.2% w/v Water to 100%

[0051] It will be appreciated that formulations suitable for human skin application may include further conventional ingredients such as emollients, fragrances, and skin conditioning agents dependent on the properties desired in addition to disinfection. Such formulations are suitable for use as surgical scrubs, cleansers for skin wounds, preoperative skin preparations, germicidal hand rinses and the like. In all cases the cationic membrane-disrupting biocide is preferably present in a concentration between 0.25% w/v and 6.00% w/v inclusive. Other similar applications include those in veterinary medicine and animal husbandry, for example in dairy hygiene products, particularly pre-milking hygiene preparations and teat dips.

[0052] The composition of the present invention may be used in combination with a wipe, for example a wipe of woven, knitted or nonwoven material, a sponge and a composite material, for example as a shampoo cap for convenient use. Suitable wipes may be made of any or a mixture of polyolefin, polyester, viscose, cotton, cellulose or other fibres. Sponge wipes may be made of polyurethane. The composition may be adsorbed by such a composite, wipe or sponge, which may be then be packaged ready to be dispensed from a tub, a bucket, a flow-wrap pack or an individually sealed wrapper or sachet.