TOPICAL ANTIMICROBIAL FORMULATIONS

Abstract

The present formulation in one embodiment is a cream that utilizes cannabinoids and terpenes (essential oils) which have powerful antibacterial activity, proven through multiple rounds of in vitro testing, to kill the most prevalent indigenous skin bacteria, including Streptococcus, Staphylococcus, and P. acnes within 30 seconds of contact. There is some independent antimicrobial activity of the cream base as well. The cream is more suitable to use on human skin because it is an emollient, is soothing, smells and feels good, and it penetrates below the dermis (lower skin level) to enter the sebaceous glands where P. acnes bacteria resides.

Claims

1. A topical formulation comprising: (a) 63 to 67% water phase formulation (b) 33 to 37% oil phase formulation comprising antimicrobial essential oils.

2. The formulation of claim 1 wherein the water phase formulation includes one or more of zinc sulfate, salicylic acid, copper sulfate, glycerin, citric acid, butylated hydroxy toluene, and distilled water.

3. The formulation of claim 1 wherein the oil phase formulation includes one or more of linalool, geraniol, menthol, and pinene.

4. The formulation of claim 3 wherein the oil phase formulation further includes one or more of cannabidiol, corn oil, MCT, Tefose HC, Prolipd 141, PEG-8 beeswax, cithrol GMS 40, and Carrageenan.

5. The formulation of claim 1 further including Emulium Mellifer MB

Description

DETAILED DESCRIPTION OF THE SYSTEM

[0006] The present formulation is a proprietary formula that possesses unique antimicrobial and anti-inflammation properties. Derivatives of the formulation are also contemplated to develop soaps, lotions, and other topically applied materials with antibacterial and antiviral properties. These may be relevant to prevent and treat other skin infections in addition to acne and surgical site infections. In one embodiment, the formulation can be used as part of a pre-operative protocol to reduce surgery related infections. The formulation can also be used topically to help prevent acne breakouts, to act as an anti-inflammatory, and to help fight existing infections.

[0007] In one embodiment, the formulation comprises a cannabinoid for the treatment or prevention of infection via topical application. The cannabinoid is chosen from the list comprising cannabidiol, cannibiol, cannabigeraol, cannabi-chromene, and tetrahydrocannabinol. The composition comprises a cannabinoid at a concentration of between 0.1 mg/ml and 10 mg/ml.

[0008] The formulation is such as to deliver a therapeutically effective amount of the cannabinoid to the dermal or mucosal surface of the subject. Therapeutically effective amount refers to an amount sufficient to inhibit bacterial growth associated with bacterial carriage and/or bacterial infection of the skin.

[0009] In one embodiment, the formulation includes cannabinoid and one or more terpenes resulting in enhanced bioavailability and enhanced solubility of CBD for treating p acnes and/or other infections.

[0010] In one embodiment, the formulation includes a beeswax in a concentration range of 2 mg/ml to 20 mg/ml. In one embodiment, the formulation includes a beeswax in a concentration of 5 mg/ml to 10 mg/ml. In embodiment, the formulation includes a beeswax in a percentage of %5 to 9%. In one embodiment, the beeswax may be PEG8 Beeswax.

[0011] In one embodiment, the formulation includes Tefose HC, Polipid 141, and Cithrol GMS 40 in various combinations. The formulation avoids salicylic acid, mineral salts (zinc, copper, silver, and the like). In one embodiment the formulation uses one or more terpenes in various combinations from a list including, but not limited to, linalool, geraniol, menthol, pinene, and the like.

[0012] The present formulation in an embodiment includes glycerin, butylated hydroxy toluene, distilled water, and the like in a water phase, and terpenes, cannabidiol, corn oil, MCT, Tefose HC, prolipid, beeswax, cithrol and carrageenan in an oil phase. The oil phase ingredients in one embodiment are heated to 75-80 degrees C. to dissolution. The water phase ingredients are combined and heated in the same temperature range until dissolution. The mixtures are combined (water phase to oil phase) while stirring until the mixture cools to less than 40 degrees C. and starts to solidify.

[0013] Table 1 illustrates embodiments of the formulation with the ingredients shown as percent of the total formulation.

TABLE-US-00001 Water Phase Ingredient A B C D E Zinc Sulfate 0 3 3 3 3 Salicylic Acid 0 0 1 0 1 Copper Sulfate 0 0 0 3 3 Glycerin 5 5 5 5 5 Citric Acid 1 1 1 1 1 Butylated Hydroxy 0.05 0.05 0.05 005 0.05 Toluene Distilled Water 59.6 56.6 55.6 53.6 52.6

TABLE-US-00002 Oil Phase Ingredient A B C D E Linalool, geraniol, 5 5 5 5 5 menthol, pinene Cannabidiol 1 1 1 1 1 Corn Oil 4 4 4 4 4 MCT 3 3 3 3 3 Tefose HC 4 4 4 4 4 Prolipid 141 5 5 5 5 5 PEG-8 Beeswax 7 7 7 7 7 Cithrol GMS 40 5 5 5 5 5 Carrageenan 0.35 0.35 0.35 0.35 0.35

[0014] The oil phase ingredients in one embodiment are heated to 75-80 degrees C. to dissolution. The water phase ingredients are combined and heated in the same temperature range until dissolution. The mixtures are combined (water phase to oil phase) while stirring until the mixture cools to less than 40 degrees C. and starts to solidify.

[0015] In one embodiment, the formulation is made with an emulsifier such as Emulium Mellifer MB, comprised of esters of jojoba wax, beeswax, and polyglycerol.

[0016] Thus, a topical antimicrobial formulation has been described.