Traditional Chinese medicine composition and the use thereof
09950024 ยท 2018-04-24
Assignee
Inventors
Cpc classification
A61K36/899
HUMAN NECESSITIES
A23V2002/00
HUMAN NECESSITIES
A61P29/00
HUMAN NECESSITIES
A61P1/14
HUMAN NECESSITIES
A23V2002/00
HUMAN NECESSITIES
A61K9/0095
HUMAN NECESSITIES
A61K36/899
HUMAN NECESSITIES
A61K2300/00
HUMAN NECESSITIES
A61K2300/00
HUMAN NECESSITIES
A23V2200/32
HUMAN NECESSITIES
A61K36/87
HUMAN NECESSITIES
A61K47/26
HUMAN NECESSITIES
A61K36/87
HUMAN NECESSITIES
A23V2200/32
HUMAN NECESSITIES
A23L19/07
HUMAN NECESSITIES
International classification
A61K36/00
HUMAN NECESSITIES
A61K36/87
HUMAN NECESSITIES
A61K9/00
HUMAN NECESSITIES
A61K47/26
HUMAN NECESSITIES
A61K36/899
HUMAN NECESSITIES
Abstract
The present invention relates to the technical field of Traditional Chinese medicine, in particular to a traditional Chinese medicine composition and the use thereof. The traditional Chinese medicine composition comprises the following ingredients: honeysuckle, tangerine peel, stir-baked malt, honey, and hawthorn juice. The traditional Chinese medicine composition of the present invention has significant promotions on the gastric emptying rate, intestinal motility, gastric digestive enzyme (pepsin) activity and pancreatic enzyme (trypsin, chymotrypsin, amylase and lipase) activity of rats, exhibiting that the traditional Chinese medicine composition of the present invention has significant effects of clearing heat-fire and moistening the intestine.
Claims
1. A composition for increasing the gastric emptying rate and improving the intestinal motility of a human in need thereof consisting essentially of 0.5-10 parts of honeysuckle extract, 0.5-10 parts of tangerine peel, 0.5-10 parts of stir-baked malt, 5-20 parts of crystal sugar, 5-20 parts honey, 5-20 parts hawthorn juice, 10-30 parts sugar cane juice, and 2-10 parts grape juice.
2. A method for increasing the gastric emptying rate and improving the intestinal motility in a subject in need thereof consisting essentially of administering to the subject a therapeutically effective amount of the traditional Chinese medicine composition according to claim 1.
Description
DETAILED DESCRIPTION
(1) The present invention discloses a traditional Chinese medicine composition and the use thereof, which may be implemented with suitable modifications of the process parameters by those skilled in the art in light of the present disclosure. It is of particular note that all the similar alterations and modifications are clear to those skilled in the art and deemed to be included in the present invention. Methods and uses of the present invention have been described by the preferred examples, and it is obvious that those in related art are able to make changes or appropriate alternations and the combinations thereof to the methods and uses described herein to implement and apply the inventive technology without departing from the disclosure, spirit and scope of the present invention.
(2) The ingredients or auxiliaries used in the traditional Chinese medicine composition and the use thereof in the present invention are all commercially available. Among them, the hawthorn juice, sugar cane juice and grape juice are concentrated fruit juice, wherein hawthorn juice has a soluble solids content of 59%, sugar cane juice has a soluble solids content of 58%, and grape juice has a soluble solids content of 65%.
(3) The present invention is further explained in combination with the examples below.
Example 1 The Preparation of the Traditional Chinese Medicine Composition
(4) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(5) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 5 g crystal sugar, 10 g honey, 15 g hawthorn juice, 30 g sugar cane juice, 2 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 2 The Preparation of the Traditional Chinese Medicine Composition
(6) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(7) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 10 g crystal sugar, 15 g honey, 20 g hawthorn juice, 10 g sugar cane juice, 5 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 3 The Preparation of the Traditional Chinese Medicine Composition
(8) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(9) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 15 g crystal sugar, 20 g honey, 5 g hawthorn juice, 20 g sugar cane juice, 8 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 4 The Preparation of the Traditional Chinese Medicine Composition
(10) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(11) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 20 g crystal sugar, 5 g honey, 10 g hawthorn juice, 25 g sugar cane juice, 10 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 5 The Preparation of the Traditional Chinese Medicine Composition
(12) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(13) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 10 g honey, 15 g hawthorn juice, and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 6 The Preparation of the Traditional Chinese Medicine Composition
(14) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(15) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 15 g honey, 20 g hawthorn juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 7 The Preparation of the Traditional Chinese Medicine Composition
(16) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(17) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 20 g honey, 5 g hawthorn juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 8 The Preparation of the Traditional Chinese Medicine Composition
(18) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(19) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 5 g honey, 10 g hawthorn juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 9 The Preparation of the Traditional Chinese Medicine Composition
(20) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(21) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 5 g crystal sugar, 10 g honey, 15 g hawthorn juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 10 The Preparation of the Traditional Chinese Medicine Composition
(22) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(23) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 10 g crystal sugar, 15 g honey, 20 g hawthorn juice, and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 11 The Preparation of the Traditional Chinese Medicine Composition
(24) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(25) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 15 g crystal sugar, 20 g honey, 5 g hawthorn juice, and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 12 The Preparation of the Traditional Chinese Medicine Composition
(26) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(27) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 20 g crystal sugar, 5 g honey, 10 g hawthorn juice, and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 13 The Preparation of the Traditional Chinese Medicine Composition
(28) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(29) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 5 g crystal sugar, 10 g honey, 15 g hawthorn juice, 30 g sugar cane juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 14 The Preparation of the Traditional Chinese Medicine Composition
(30) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(31) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 10 g crystal sugar, 15 g honey, 20 g hawthorn juice, 10 g sugar cane juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 15 The Preparation of the Traditional Chinese Medicine Composition
(32) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(33) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 15 g crystal sugar, 20 g honey, 5 g hawthorn juice, 20 g sugar cane juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 16 The Preparation of the Traditional Chinese Medicine Composition
(34) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(35) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 20 g crystal sugar, 5 g honey, 10 g hawthorn juice, 25 g sugar cane juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 17 The Preparation of the Traditional Chinese Medicine Composition
(36) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(37) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 10 g honey, 15 g hawthorn juice, 30 g sugar cane juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 18 The Preparation of the Traditional Chinese Medicine Composition
(38) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(39) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 15 g honey, 20 g hawthorn juice, 10 g sugar cane juice, and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 19 The Preparation of the Traditional Chinese Medicine Composition
(40) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(41) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 20 g honey, 5 g hawthorn juice, 20 g sugar cane juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 20 The Preparation of the Traditional Chinese Medicine Composition
(42) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(43) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 5 g honey, 10 g hawthorn juice, 25 g sugar cane juice, and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 21 The Preparation of the Traditional Chinese Medicine Composition
(44) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(45) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 10 g honey, 15 g hawthorn juice, 30 g sugar cane juice, 2 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 22 The Preparation of the Traditional Chinese Medicine Composition
(46) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(47) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 15 g honey, 20 g hawthorn juice, 10 g sugar cane juice, 5 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 23 The Preparation of the Traditional Chinese Medicine Composition
(48) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(49) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 20 g honey, 5 g hawthorn juice, 20 g sugar cane juice, 8 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 24 The Preparation of the Traditional Chinese Medicine Composition
(50) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(51) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 5 g honey, 10 g hawthorn juice, 25 g sugar cane juice, 10 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 25 The Preparation of the Traditional Chinese Medicine Composition
(52) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(53) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 5 g crystal sugar, 10 g honey, 15 g hawthorn juice, 2 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 26 The Preparation of the Traditional Chinese Medicine Composition
(54) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(55) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 10 g crystal sugar, 15 g honey, 20 g hawthorn juice, 5 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 27 The Preparation of the Traditional Chinese Medicine Composition
(56) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(57) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 15 g crystal sugar, 20 g honey, 5 g hawthorn juice, 8 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 28 The Preparation of the Traditional Chinese Medicine Composition
(58) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(59) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 20 g crystal sugar, 5 g honey, 10 g hawthorn juice, 10 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 29 The Preparation of the Traditional Chinese Medicine Composition
(60) Extraction: 0.5 g honeysuckle, 1 g tangerine peel and 5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 10 times of water the extraction was performed at 92 C. for 3 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(61) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 31.5 g water, 10 g honey, 15 g hawthorn juice, 2 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 30 The Preparation of the Traditional Chinese Medicine Composition
(62) Extraction: 1 g honeysuckle, 5 g tangerine peel and 10 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 12 times of water the extraction was performed at 95 C. for 2 hours and repeated twice to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(63) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 24.0 g water, 15 g honey, 20 g hawthorn juice, 5 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 31 The Preparation of the Traditional Chinese Medicine Composition
(64) Extraction: 5 g honeysuckle, 10 g tangerine peel and 0.5 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 14 times of water the extraction was performed at 100 C. for 3 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(65) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 16.5 g water, 20 g honey, 5 g hawthorn juice, 8 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 32 The Preparation of the Traditional Chinese Medicine Composition
(66) Extraction: 10 g honeysuckle, 0.5 g tangerine peel and 1 g stir-baked malt were weighed in proportion according to the formulation, and these materials were put into an extraction tank, then after the addition of 15 times of water the extraction was performed at 90 C. for 2 hours and repeated three times to obtain an extract, which was concentrated into a concentrate with a soluble solids content of 15-25%.
(67) Formulation: the ingredients were weighed in proportion according to the formulation, and to the formulation tank were added: 18.5 g water, 5 g honey, 10 g hawthorn juice, 10 g grape juice and the concentrate described above. After the intermediates were stirred continuously for 10-15 min, the stirring was stopped and a sample was removed for tests, and after passing the tests, the traditional Chinese medicine composition was obtained.
Example 33 Tests of Effects
(68) 1 Experimental Samples and Methods
(69) 1.1 Experimental Samples
(70) The traditional Chinese medicine compositions of Examples 1 to 8 of the present application were taken as experimental samples, the composition of Example 3 in Publication No. CN 102511880A as Control A, the composition of Example 1 disclosed in Publication No. CN 103417876 A as Control B, and pure water as Control C.
(71) 1.2 Experimental Objects
(72) Adult rats were taken as experimental objects, and divided into 11 groups, that is, Example 1 to 8 groups, Control A group, Control B group and Control C group to conduct the experiments, with an amount of 20 rats in each group.
(73) The rats were filled and fed using Example 1 to 8 groups, Control A, Control B and Control C 5 days a week for two weeks.
(74) 1.3 Experimental Methods
(75) The gastric emptying rate, intestinal motility, gastric digestive enzymes (pepsin) and pancreatic enzymes (trypsin, chymotrypsin, amylase and lipase) activity of rats were detected, and the effects of the tested samples were evaluated by comparing the experimental sample groups, A group and B group with C group respectively.
(76) 2. Experimental Results
(77) TABLE-US-00009 TABLE 1 The gastric emptying rates of the rats in different groups Group 2 Weeks Example 1 28% Example 2 30% Example 3 25% Example 4 24% Example 5 27% Example 6 26% Example 7 29% Example 8 25% Control A 8% Control B 17% Control C no significant effects
(78) TABLE-US-00010 TABLE 2 The intestinal motility of the rats in different groups Group 2 Weeks Example 1 25% Example 2 27% Example 3 26% Example 4 24% Example 5 26% Example 6 28% Example 7 24% Example 8 27% Control A 5% Control B 15% Control C no significant effects
(79) TABLE-US-00011 TABLE 3 The pepsin activity of the rats in different groups Group 2 Weeks Example 1 30% Example 2 32% Example 3 27% Example 4 26% Example 5 31% Example 6 32% Example 7 28% Example 8 29% Control A 10% Control B 16% Control C no significant effects
(80) TABLE-US-00012 TABLE 4 The pancreatic enzyme activity of the rats in different groups Group Trypsin Chymotrypsin Amylase Lipase Example 1 12% 15% 23% 44% Example 2 14% 16% 27% 43% Example 3 13% 14% 22% 40% Example 4 10% 15% 24% 41% Example 5 13% 14% 26% 43% Example 6 14% 15% 25% 42% Example 7 12% 16% 25% 44% Example 8 12% 15% 27% 41% Control A no no significant 4% 5% significant effects effects Control B 5% 10% 10% 20% Control C no no significant no significant no significant significant effects effects effects effects
(81) As seen from Table 1, the compositions of Examples 1 to 8 of the present invention may significantly improve the gastric emptying rates (24% to 30%) of rats, which are substantially higher than those of Control A (8%) and Control B (17%).
(82) As seen from Table 2, the compositions of Examples 1 to 8 of the present invention may significantly improve the intestinal motility (24% to 28%) of rats, which are substantially higher than those of Control A (5%) and Control B (15%).
(83) As seen from Table 3, the compositions of Examples 1 to 8 of the present invention may significantly improve the pepsin activity (26% to 32%) of rats, which are substantially higher than those of Control A (10%) and Control B (16%).
(84) As seen from Table 4, the compositions of Examples 1 to 8 of the present invention may significantly improve the trypsin (10% to 14%), chymotrypsin (14% to 16%), amylase (22% to 27%) and lipase (40% to 44%) activity of rats, which are substantially higher than those of Control A (8%) and Control B (17%).
(85) A comprehensive analysis of the results above shows that the obtained compositions of the present invention have significant promotions on the gastric emptying rate, intestinal motility, gastric digestive enzyme (pepsin) activity and pancreatic enzyme (trypsin, chymotrypsin, amylase and lipase) activity of rats, which are superior to those of Control A and Control B, exhibiting that the traditional Chinese medicine compositions of the present invention have significant effects of clearing heat, lowering fire and moistening the intestine.
Example 34 The Preparation of the Juice Beverage
(86) Homogenization: the traditional Chinese medicine composition obtained in Example 1 was taken and pre-heated to 60 C. before entering the homogenizer having a pressure of 30 Mpa.
(87) Sterilization: The intermediates were sterilized using UHT sterilizer at a sterilizing temperature of 120 C. for a sterilizing time of 30 s.
(88) Bottling: the bottling temperature is 65-75 C., and the bottling concentration is generally 45-55%.
(89) Cooling: the concentrate after bottling was cooled by water spraying at normal temperature for 30 min, with a temperature after cooling <40 C.
(90) Light examination and packaging were performed to obtain the juice beverage.
Example 35 The Preparation of the Juice Beverage
(91) Homogenization: the traditional Chinese medicine composition obtained in Example 2 was taken and pre-heated to 65 C. before entering the homogenizer having a pressure of 20 Mpa.
(92) Sterilization: The intermediates were sterilized using UHT sterilizer at a sterilizing temperature of 130 C. for a sterilizing time of 10 s.
(93) Bottling: the bottling temperature is 65-75 C., and the bottling concentration is generally 45-55%.
(94) Cooling: the concentrate after bottling was cooled by water spraying at normal temperature for 30 min, with a temperature after cooling <40 C.
(95) Light examination and packaging were performed to obtain the juice beverage.
Example 36 The Preparation of the Juice Beverage
(96) Homogenization: the traditional Chinese medicine composition obtained in Example 3 was taken and pre-heated to 70 C. before entering the homogenizer having a pressure of 15 Mpa.
(97) Sterilization: The intermediates were sterilized using UHT sterilizer at a sterilizing temperature of 135 C. for a sterilizing time of 5 s.
(98) Bottling: the bottling temperature is 65-75 C., and the bottling concentration is generally 45-55%.
(99) Cooling: the concentrate after bottling was cooled by water spraying at normal temperature for 30 min, with a temperature after cooling <40 C.
(100) Light examination and packaging were performed to obtain the juice beverage.
(101) The above description gives only the preferred embodiments of the present invention, and it should be noted that for those of ordinary skill in the art, a number of improvements and modifications can be made without departing from the principle of the invention, which are also regarded as falling into the scope claimed in the present invention.