USE OF AFRICAN SEED EXTRACT FOR HUNGER SUPPRESSION

Abstract

A composition and method for the use of Irvingia gabonensis seed extract for hunger suppression in obese individuals with low Leptin sensitivity, individuals with higher levels of ghrelin, and for individuals with Cannabis-induced appetite stimulation where dosage can be effectively administered in a gum base cold pressed into a tablet containing at least 100 mg of Irvingia gabonensis seed extract and Maltitol, Sorbitol, Isomalt, Xylitol, natural & artificial flavors, vegetarian magnesium stearate, Sucralose and Silicon dioxide.

Claims

1. A composition of Irvingia gabonensis seed extract comprising a dosage in an amount effective for hunger suppression in obese individuals with low Leptin sensitivity, individuals with higher levels of ghrelin and for individuals with Cannabis-induced appetite stimulation.

2. The composition of claim 1 where the composition of Irvingia gabonensis seed extract is incorporated within a gum base for efficacious delivery to the user through the ordinary process of gum chewing.

3. The composition of claim 2 where the gum base is cold pressed into a tablet containing Irvingia gabonensis seed extract in an amount of 100 mg.

4. The composition of claim 3 where the gum base further comprises Maltitol, Sorbitol, Isomalt, Xylitol, natural & artificial flavors, vegetarian magnesium stearate, Sucralose and Silicon dioxide.

5. A method for hunger suppression in obese individuals with low Leptin sensitivity, individuals with higher levels of ghrelin, and for individuals with Cannabis-induced appetite stimulation comprising the administering of an effective amount of a composition of Irvingia gabonensis seed extract where the amount of Irvingia gabonensis seed extract is 100 mg.

6. The method of claim 5 where the composition of Irvingia gabonensis seed extract is incorporated within a gum base for efficacious delivery to the user through the ordinary process of gum chewing.

7. The method of claim 6 where the gum base is cold pressed into a tablet further comprising Maltitol, Sorbitol, Isomalt, Xylitol, natural & artificial flavors, vegetarian magnesium stearate, Sucralose and Silicon dioxide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0007] The present invention described herein is the use of the seed of Irvingia gabonensis (aka African mango tree), including any processed (e.g. extracts, conjugates, heated, cooked, etc.) or unprocessed form of the seed, for those with low Leptin sensitivity as well as for the attenuation of Cannabis-induced appetite stimulation incorporated within a gum base with the below included ingredients for efficacious delivery to the user through the ordinary process of gum chewing. The gum base is formulated utilizing a cold pressed manufacturing process to incorporate all of the ingredients with heightened efficacy into a circular half inch diameter tablet. The ingredients incorporated into the gumbase are, Maltitol, Sorbitol, Isomalt, Xylitol, African mango seed extract (Irvingia gabonensis) 100 mg per piece, natural & artificial flavors, vegetarian magnesium stearate, Sucralose and Silicon dioxide.

[0008] Irvingia gabonensis is a fruit-producing tree native to the forested regions of central Africa, including the countries of Congo, Nigeria, Cameroon, Ghana, Togo, and Uganda. The seeds of Irvingia gabonensis are edible and are used for various purposes, including appetite suppression. The appetite suppressive effects of Irvingia gabonensis has been shown to result from increased leptin expression and/or enhanced leptin sensitivity (Oben J E, Ngondi J L, Blum K. Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene. Lipids Health Dis. 7:44, 2008). These leptin-related effects and properties of the seeds of Irvingia gabonensis specifically counteract low leptin sensitivity and a mechanism of cannabis-induced appetite stimulation and as such is postulated to have utility in the attenuation of appetite stimulation. Initial subjective trials of Irvingia gabonensis seed extract have been conducted by the inventors in adult volunteer normal dieting and Cannabis users and self-reported to be effective in attenuating low leptin sensitivity and Cannabis-induced appetite stimulation.