Laminar evaporator
11484670 · 2022-11-01
Assignee
Inventors
Cpc classification
International classification
A61M11/04
HUMAN NECESSITIES
Abstract
The disclosure relates to a laminar evaporator including an electrical resistance heating element for pulse heating and evaporation of an inhalationally receivable material distributed or distributable on the heating element surface by an electric heating current flowing or flowable in a laminar manner with at least two electrical contacts or poles for introducing the heating current into the resistance heating element, wherein the resistance heating element has at least one slot-shaped recess constricting lines of flux of an original electric field forming or formable between the at least two electrical contacts or poles and comprises a porous structure having a porosity of 70% or greater holding or capable of holding the material.
Claims
1. An evaporator comprising: an electrical resistance heating element for pulse heating and evaporation of an inhalationally receivable material distributed or distributable on a surface of the electrical resistance heating element by an electric heating current flowing or flowable in a laminar manner with at least two electrical contacts or poles for introducing the electric heating current into the electrical resistance heating element, wherein the electrical resistance heating element has at least one cut constricting lines of flux of an original electric field forming or formable between the at least two electrical contacts or poles and comprises a porous structure having a porosity of 70% or greater holding or capable of holding the material, the at least one cut being spaced apart from edges of the electrical resistance heating element.
2. The evaporator of claim 1, wherein the electrical resistance heating element consists of an electrically resistant material and the at least one cut penetrates the electrical resistance heating element.
3. The evaporator of claim 2, wherein the electrical resistance heating element is formed entirely by the porous structure.
4. The evaporator of claim 3, wherein the porous structure forms a wick.
5. The evaporator of claim 1, wherein the at least one cut extends essentially in a straight line and is aligned at least approximately at right angles to the lines of flux of the original electric field constricted by the at least one cut.
6. The evaporator of claim 1, wherein the electrical resistance heating element consists of a metallic resistance material.
7. The evaporator of claim 1, wherein the at least one cut comprises a plurality of cuts.
8. The evaporator of claim 7, wherein the plurality of cuts are unevenly closely distributed on the surface of the electrical resistance heating element.
9. An inhaler component comprising at least one evaporator according to claim 1.
10. An inhaler component comprising the evaporator of claim 4 and with a source of liquid, communicating or capable of communicating via capillary action with the wick to supply the wick with the liquid, wherein the wick is supplied with the liquid in a direction of the lines of flux of the original electric field and the at least one cut comprises a plurality of cuts arranged staggered one behind another in a row aligned essentially parallel to the lines of flux.
11. An inhaler component comprising the evaporator of claim 4 and with a source of liquid communicating or capable of communicating via capillary action with the wick to supply the wick with the liquid, wherein the wick is fed transverse to the lines of flux of the original electric field with the liquid and the at least one cut points essentially in a direction of filling.
12. An evaporator comprising: an electrical resistance heating element for pulse heating and evaporation of an inhalationally receivable material distributed or distributable on a surface of the electrical resistance heating element by an electric heating current flowing or flowable in a laminar manner with at least two electrical contacts or poles for introducing the electric heating current into the electrical resistance heating element, wherein the electrical resistance heating element has at least one cut constructing lines of flux of an original electric field forming or formable between the at least two electrical contacts or poles, wherein the electrical resistance heating element consists of an electrically resistant material and the at least one cut penetrates the electrical resistance heating element and is spaced apart from edges of the electrical resistance heating element, wherein the electrical resistance heating element is formed entirely by a porous structure.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) Appropriate and advantageous examples of the disclosure are represented in the drawings and are described below in more detail. The drawings show:
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DETAILED DESCRIPTION
(13) Table 1 shows the material specifications of an exemplary laminar evaporator in accordance with the disclosure. According to this the laminar evaporator consists of six layers: a metal foil and five metal wire meshes sintered onto it. The metal in the present example consists of the heat-conducting alloy NiCr8020, DIN material number 2.4869. Different heat-conducting alloys could of course also be used. Heat-conducting alloys can be ordered as starting material from the company ThyssenKrupp VDM GmbH, www.thyssenkruppvdm.de, and then processed into foils, fine wires and wire meshes. ThyssenKrupp VDM GmbH supplies the previously mentioned material NiCr8020, DIN material number 2.4869, under the trade name “Cronix 80”, which can also be fused to a very pure specification with a carbon content<0.02%. The company Record Metall-Folien GmbH, www.recordmetall.de, in co-operation with its suppliers, is in a position to make available metal foils from a thickness of 5 μm from starting material preferably in the form of strip. The company J. G. Dahmen & Co. GmbH & Co. KG, www.dahmen-draht.de, is able to draw fine wires starting from a thickness of 18 μm from starting material that can be in the form of wire. The fine wires can subsequently be routinely woven into wire mesh by wire weaving mills, for example by the companies Haver & Boecker, www.haverboecker.com, or Sporl KG, www.spoerl.de.
(14) The metal foil and the wire mesh layers are connected by sintering. Sintering can take place under vacuum or under a protective atmosphere of hydrogen. Such sintering counts as state of the art and can be routinely carried out, for example, by the company GKN Sinter Metals Filters GmbH, www.gkn-filters.com, as well as by the company Sporl KG, www.spoerl.de. Sintering is advantageously effected in the form of multiple cutouts; that is, the individual laminar evaporators are not sintered, but larger area cutouts are used, for example in the format 200×200 mm. The individual laminar evaporators are obtained from the multiple cutouts after sintering by laser cutting or stamping machines.
(15) Instead of heat-conducting alloys, stainless steels, e.g. AISI 304L or AISI 316L, are also used as alternative materials for the laminar evaporator in accordance with the invention. These have substantial cost advantages over NiCr8020, but nevertheless have a distinctly lower electrical resistance compared with NiCr8020. To increase the electrical resistance the stainless steel laminar evaporators or the intermediate products of which they are made—the multiple cutouts—can optionally be etched.
(16) Material is evenly removed by etching. The etching can advantageously be carried out in an aqueous pickling bath consisting of 50% nitric acid and 13% hydrofluoric acid. Such pickling baths can be supplied under the designation “Avesta 302” by the company Avesta Finishing Chemicals, www.avestafinishing.com. A favorable side effect of the etching is that it also increases the porosity of the laminar evaporator somewhat, as a result of which the evaporator becomes more absorptive for the material to be evaporated. However, the additional process of etching at least partly reduces the original cost advantages compared with heat-conducting alloys.
(17) An interesting option also consists of combining heat-conducting alloys and stainless steels, where the more substantial layers can consist of a heat-conducting alloy and the finer layers of stainless steel. In the specific example in accordance with Table 1, this option could mean, for example, that the three outside layers, namely layers 3 to 5, could be made of stainless steel.
(18) TABLE-US-00001 TABLE 1 Material specifications Material: NiCr8020 DIN 2.4869, “Cronix80” Metal foil thickness .sup. 5 μm alternatively 10 μm 1.sup.st wire mesh layer: 90 × 36 μm mesh size × wire size 2.sup.nd wire mesh layer: 71 × 30 μm mesh size × wire size 3.sup.rd wire mesh layer: 56 × 20 μm mesh size × wire size 4.sup.th wire mesh layer: 65 × 20 μm mesh size × wire size 5.sup.th wire mesh layer: 45 × 18 μm mesh size × wire size Thickness: .sup. 222 μm after sintering Porosity: 70% Specific electrical 8.4 resistance: [mOhm mm] Heat conductivity: 2.1-2.7 *) [W/mK] *) in the temperature range 20° C. to 400° C.
(19) With laminar evaporators constructed in accordance with Table 1 the porous structure is formed by sintering the wire mesh layers with one another. Both the wire mesh layers and the metal foil make a contribution to the resulting electrical resistance heater. The values for specific electrical resistance and for the heat conductivity stated in Table 1 are of course valid in the surface direction. The values decrease disproportionately as the porosity increases.
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(22) The constriction of the electrical lines of flux 6 entails an uneven distribution of the electric field strength. Specifically, in zone 9 directly bordering the ends of 8 of the cutouts 5, where the lines of flux are most strongly constricted, particularly high field strengths arise almost selectively, while in the zones 10 bordering the cuts 5 the field strength exhibits comparatively low values. Since the field strength enters the calculation of the electric power density as a square, it can be expected that the electric power density will vary even more, which
(23) Table 2 describes the composition of the material to be evaporated. Accordingly, the material in the specific example consists of a nicotine solution highly diluted with ethanol and water. Glycerol is used as an aerosol former. Furthermore a range of organic acids are added to protonate the nicotine. The pores of the porous structure are completely filled with the nicotine solution, as a result of which a total of 10.4 μL nicotine solution is stored in the porous structure. The material released in the course of the evaporation is essentially determined by the ternary system ethanol-water-glycerol. The task of releasing the ingredients set out in Table 2 as synchronously as possible will succeed if the two groups of main materials, the solvent (ethanol and water) on the one hand and the aerosol former (glycerol) on the other hand, are released as synchronously as possible. The fact that this task is not simple can be seen from the substantially different material properties of these groups of materials alone—see Table 2a.
(24) TABLE-US-00002 TABLE 2 Example of drug preparation based on nicotine Material CAS number % by weight Ethanol 64-17-5 67.13 Water 7732-18-5 17.72 Glycerol 56-81-5 11.08 Nicotine 54-11-5 1.33 Lactic acid 50-21-5 0.11 Succinic acid 110-15-6 0.18 Levulinic acid 123-76-2 0.40 Benzoic acid 65-85-0 0.07 Acetic acid 64-19-7 1.30 Formic acid 64-18-6 0.43 Solanon 1937-54-8 0.07 Tobacco flavouring oils 0.18 Total: 100.00
(25) TABLE-US-00003 TABLE 2a Material properties ethanol-water-glycerol Boiling point Vapour pressure at 20° C. Ethanol 78° C. 5800 Pa Water 100° C. 2340 Pa Glycerol 290° C. <0.1 Pa
(26) In solving the heat conduction equation the electric power density shown in
(27) TABLE-US-00004 TABLE 3 Current flow - modulation percentage [%] Time [s] [%] 0.00-0.52 100 0.52-0.55 80 0.55-0.60 60 0.60-0.70 40 0.70-1.40 35 1.40-1.50 25 1.50-1.55 15 1.55-1.60 10 1.60-2.00 0
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(30) The slot length must be adjusted to the specific material properties of the laminar evaporator, in particular to the heat conductivity of the porous structure, where in the long run a compromise must be found: excessively long slots and/or cuts lead to zones being formed locally with no or very little evaporation. The material to be evaporated is only slightly heated in such zones. Such zones can also be called dead zones, because they play little or no part in the evaporation. If the slot length is made too short, however, the potential of the slot to form steep temperature gradients will not be exploited to the fullest extent.
(31) The supply of the laminar evaporator 1 with electric current in accordance with
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(33) The supply of the capillary structure with the liquid 19 to be evaporated takes place in the example in accordance with
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(35) In selecting the materials for the construction units for forming the capillary gap 16 care should be taken to achieve good wettability of the same with the liquid to be evaporated 19. This condition is valid both for the arrangement in accordance with
(36) The structure of a laminar evaporator in accordance with the invention shown as an example in Table 1 is based on the fact that several metal fabric layers are sintered onto a metal foil. With evaporators of this design the vapors formed can only exit from the porous structure on the side opposite the metal foil. As an alternative to this design laminar evaporators with the porous structure open on both sides can also be used where it is particularly advantageous if the resistance heating element is formed entirely of the porous structure. Laminar evaporators of this design allow particularly high evaporation rates. Such an evaporator can, for example, consist of an electrically conducting open-pored foam material. Such foam material made of e.g. AISI 316L stainless steel can be obtained from the company Mitsubishi Materials Corporation, www.mmc.co.jp. Here the starting point was a standard foam material with a thickness of 0.5 mm, a pore diameter within the range 50-150 μm and a porosity of about 90%. The material can be reduced by rollers as required to a thickness of, for instance, 100 μm. The consolidated material can subsequently still be sintered if required. The compression naturally also reduces the porosity, which can be increased again, however, if necessary in the course of a subsequent etching treatment. Heat-conducting alloys, in particular from the group of NiCr alloys, e.g. NiCr8020, DIN material No. 2.4869, can be likewise converted to such a foam material. The laminar evaporator can consist of a single foam layer or of several foam layers sintered together. To increase the stability and strength of the laminar evaporator the foam can optionally be sintered onto a thin support layer, for example onto a wire mesh of stainless steel or a heat-conducting alloy. The laminar foam material can be made to any shape by laser cutting. The slot-shaped recesses and/or cuts in accordance with the invention are again preferably made in the foam material by means of an Nd:YAG laser.
(37) In all the foregoing examples shown the slot-shaped recesses and/or cuts proceed from the edges of the laminar evaporator. The invention is, of course, not limited to this arrangement. Rather the slot-shaped recesses and/or cuts can also be disposed spaced apart from the edges. Slots arranged in this way have a double-constricting effect, since in this case both ends of slit restrict the lines of flux of the original electric field.
REFERENCE SYMBOL LIST
(38) 1 laminar evaporator 2 first pole 3 second pole 4 lines of flux of the original electric field 5 slot-shaped recess; cut 6 constricted lines of flux 7 edge 8 end of slit 9 zone of high electric field strength 10 zone of low electric field strength 11 zone of highest power density 12 edge zone of lowest power density 13 middle zone of medium power density 14 plate-shaped contact element 15 periphery 16 capillary gap 17 upper section 18 liquid reservoir 19 liquid 20 vent hole 21 main supply channel 22 tongue 23 printed circuit board 24 cover plate 25 extension