PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS

Abstract

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

##STR00001##

Claims

1. A compound of the formula (I) ##STR00056## wherein R.sup.1 is CN or C(?S)NH.sub.2; R.sup.2 is H, OH, halogen, C.sub.1-C.sub.6-alkoxy or C.sub.1-C.sub.6-haloalkoxy; R.sup.3 is H, OH, halogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkoxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyloxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-haloalkenyloxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkynyloxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-haloalkynyloxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-cycloalkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-halocycloalkoxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkylsulfonyl-C.sub.1-C.sub.6-alkyl; C.sub.1-C.sub.6-alkylsulfonyl-C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.6-cyanoalkyl, C.sub.3-C.sub.6-cyanocycloalkyl R.sup.4 is C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, phenyl, phenyl substituted with 1 to 3 independently selected substituents R.sup.5, heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic), heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic) substituted with 1 to 3 independently selected substituents R.sup.6; R.sup.5 is independently selected from halogen, cyano, pentafluoro-?.sup.6-sulfanyl, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.3-C.sub.6-cyanocycloalkyl, C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-alkylcarbonyl, C.sub.1-C.sub.6-alkylcarbamoyl, C.sub.1-C.sub.6-alkylsulfonyl, C.sub.1-C.sub.6-haloalkylsulfanyl, and OC.sub.1-2haloalkanediyl-O; and R.sup.6 is independently selected from halogen, cyano, pentafluoro-?.sup.6-sulfanyl, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.3-C.sub.6-cyanocycloalkyl, C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-alkylcarbonyl, C.sub.1-C.sub.6-alkylcarbamoyl, C.sub.1-C.sub.6-alkylsulfonyl, and C.sub.1-C.sub.6-haloalkylsulfanyl; Q is a cyclic amine represented by the formula IIa or a cyclic amine represented by the formula IIb, ##STR00057## wherein the arrow indicates the connection to the carbonyl group; p.sup.1 is 0, 1 or 2 and indicates the number of methylene groups; p.sup.2 is 0, 1 or 2 and indicates the number of methylene groups; q.sup.1 is 1 or 2 and indicates the number of methylene groups; q.sup.2 is 1 or 2 and indicates the number of methylene groups; X is hydrogen, hydroxyl, alkoxy, or halogen; Y is selected from the formulae Y.sup.1 to Y.sup.32 wherein the arrow indicates the connection to the cyclic amine of formula IIa; ##STR00058## ##STR00059## ##STR00060## A is selected from the formulae A.sup.1 to A.sup.12 wherein the arrow indicates the connection to the cyclic amine of formula IIb; ##STR00061## R.sup.7, R.sup.8, R.sup.9 and R.sup.14, independent of the A and Y groups, are selected from hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl and C.sub.3-C.sub.6-halocycloalkyl; R.sup.10, independent of the A and Y groups, is C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl and a 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo; R.sup.11 and R.sup.12, independent of the A and Y groups, are selected from hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl and C.sub.3-C.sub.6-halocycloalkyl; or R.sup.11 and R.sup.12 together with the carbon to which they are attached form a C.sub.3-C.sub.6-cycloalkyl; R.sup.13, independent of the A and Y groups, is hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl and a 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo; R.sup.15, independent of the A and Y groups, is C.sub.3-C.sub.6-cycloalkyl, a 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo, phenyl, phenyl substituted with 1 to 3 independently selected substituents R.sup.16, heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic), or heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic) substituted with 1 to 3 independently selected substituents R.sup.17; R.sup.16 is independently selected from halogen, cyano, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-alkylcarbonyl, C.sub.1-C.sub.6-alkylcarbamoyl, C.sub.1-C.sub.6-alkylsulfonyl, C.sub.1-C.sub.6-haloalkylsulfanyl, and OC.sub.1-2haloalkanediyl-O; and R.sup.17 is independently selected from halogen, cyano, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-alkylcarbonyl, C.sub.1-C.sub.6-alkylcarbamoyl, C.sub.1-C.sub.6-alkylsulfonyl, and C.sub.1-C.sub.6-haloalkylsulfanyl; or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer and N-oxide of the compound of formula (I).

2. The compound according to claim 1 wherein R.sup.1 is CN.

3. The compound according to either claim 1 or claim 2 wherein R.sup.2 is H.

4. The compound according to any one of claims 1 to 3 wherein R.sup.3 is H, OH, halogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-haloalkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.2-C.sub.6-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkoxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyloxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-haloalkenyloxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkynyloxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-haloalkynyloxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-cycloalkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-halocycloalkoxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkylsulfonyl-C.sub.1-C.sub.6-alkyl; C.sub.1-C.sub.6-alkylsulfonyl-C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.6-cyanoalkyl, or C.sub.3-C.sub.6-cyanocycloalkyl.

5. The compound according to any one of claims 1 to 4 wherein R.sup.4 is C.sub.3-C.sub.5-cycloalkyl, C.sub.3-C.sub.5-halocycloalkyl, phenyl, phenyl substituted with 1 to 3 independently selected substituents R.sup.5, heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic), heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic) substituted with 1 to 3 independently selected substituents R.sup.6, wherein R.sup.5 and R.sup.6 are as defined in claim 1.

6. The compound according to claim 5 wherein R.sup.4 is phenyl substituted with 1 to 3 substituents R.sup.5, wherein R.sup.5 is independently selected from halogen, cyano, pentafluoro-?.sup.6-sulfanyl, C.sub.1-C.sub.3-alkyl, C.sub.1-C.sub.3-haloalkyl, C.sub.2-C.sub.4-alkenyl, C.sub.2-C.sub.4-haloalkenyl, C.sub.2-C.sub.4-alkynyl, C.sub.2-C.sub.4-haloalkynyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.3-C.sub.4-cyanocycloalkyl, C.sub.1-C.sub.3-alkoxy, C.sub.1-C.sub.3-haloalkoxy, C.sub.1-C.sub.3-alkylcarbonyl, C.sub.1-C.sub.3-alkylcarbamoyl, C.sub.1-C.sub.3-alkylsulfonyl, C.sub.1-C.sub.3-haloalkylsulfanyl, and OC.sub.1-2haloalkanediyl-O.

7. The compound according to any one of claims 1 to 6 wherein Q is a cyclic amine represented by the formula IIa, wherein both p.sup.1 and p.sup.2 are 1; X is hydrogen and Y is selected from the formulae Y.sup.1 to Y.sup.32, as defined in claim 1, and wherein R.sup.7, R.sup.8, R.sup.9 and R.sup.14, independent of each other and the Y groups, are hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl or C.sub.3-C.sub.6-halocycloalkyl; R.sup.10, independent of the Y groups, is hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, or 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo; R.sup.11 and R.sup.12, independent of each other and the Y groups, are hydrogen, C.sub.1-C.sub.6-alkyl, or C.sub.1-C.sub.6-haloalkyl, or R.sup.11 and R.sup.12 together with the carbon to which they are attached form a C.sub.3-C.sub.4-cycloalkyl; R.sup.13, independent of the Y groups, is hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, or 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo; R.sup.15, independent of the Y groups, is C.sub.3-C.sub.4-cycloalkyl, a 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo, phenyl, phenyl substituted with 1 to 3 independently selected substituents R.sup.16, heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic), or heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic) substituted with 1 to 3 independently selected substituents R.sup.17; R.sup.16, independent of the Y groups, is halogen, cyano, C.sub.1-C.sub.3-alkyl, C.sub.1-C.sub.3-haloalkyl, C.sub.2-C.sub.4-alkenyl, C.sub.2-C.sub.4-haloalkenyl, C.sub.2-C.sub.4-alkynyl, C.sub.2-C.sub.4-haloalkynyl, C.sub.1-C.sub.3-alkoxy, C.sub.1-C.sub.3-haloalkoxy, C.sub.1-C.sub.3-alkylcarbonyl, C.sub.1-C.sub.3-alkylcarbamoyl, C.sub.1-C.sub.3-alkylsulfonyl, C.sub.1-C.sub.3-haloalkylsulfanyl, or OC.sub.1-2haloalkanediyl-O; and R.sup.17, independent of the Y groups, is halogen, cyano, C.sub.1-C.sub.3-alkyl, C.sub.1-C.sub.3-haloalkyl, C.sub.2-C.sub.4-alkenyl, C.sub.2-C.sub.4-haloalkenyl, C.sub.2-C.sub.4-alkynyl, C.sub.2-C.sub.4-haloalkynyl, C.sub.1-C.sub.3-alkoxy, C.sub.1-C.sub.3-haloalkoxy, C.sub.1-C.sub.3-alkylcarbonyl, C.sub.1-C.sub.3-alkylcarbamoyl, C.sub.1-C.sub.3-alkylsulfonyl, or C.sub.1-C.sub.3-haloalkylsulfanyl.

8. The compound according to any one of claims 1 to 6 wherein Q is a cyclic amine represented by the formula IIb, wherein both q.sup.1 and q.sup.2 are 1; and A is selected from the formulae A.sup.1 to A.sup.12, as defined in claim 1, and wherein R.sup.7, R.sup.8, R.sup.9 and R.sup.14, independent of each other and the A groups, are hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl or C.sub.3-C.sub.6-halocycloalkyl; R.sup.10, independent of the A groups, is hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, or 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo; R.sup.11 and R.sup.12, independent of each other and the A groups, are hydrogen, C.sub.1-C.sub.6-alkyl, or C.sub.1-C.sub.6-haloalkyl, or R.sup.11 and R.sup.12 together with the carbon to which they are attached form a C.sub.3-C.sub.4-cycloalkyl; R.sup.13, independent of the A groups, is hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, or 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo; R.sup.15, independent of the A groups, is C.sub.3-C.sub.4-cycloalkyl, a 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl, which ring system can be substituted by an oxo, phenyl, phenyl substituted with 1 to 3 independently selected substituents R.sup.16, heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic), or heteroaryl (which is either a 5 or 6 membered monocyclic or a 8, 9 or 10 membered bicyclic) substituted with 1 to 3 independently selected substituents R.sup.17; R.sup.16, independent of the A groups, is halogen, cyano, C.sub.1-C.sub.3-alkyl, C.sub.1-C.sub.3-haloalkyl, C.sub.2-C.sub.4-alkenyl, C.sub.2-C.sub.4-haloalkenyl, C.sub.2-C.sub.4-alkynyl, C.sub.2-C.sub.4-haloalkynyl, C.sub.1-C.sub.3-alkoxy, C.sub.1-C.sub.3-haloalkoxy, C.sub.1-C.sub.3-alkylcarbonyl, C.sub.1-C.sub.3-alkylcarbamoyl, C.sub.1-C.sub.3-alkylsulfonyl, C.sub.1-C.sub.3-haloalkylsulfanyl, or OC.sub.1-2haloalkanediyl-O; and R.sup.17, independent of the A groups, is halogen, cyano, C.sub.1-C.sub.3-alkyl, C.sub.1-C.sub.3-haloalkyl, C.sub.2-C.sub.4-alkenyl, C.sub.2-C.sub.4-haloalkenyl, C.sub.2-C.sub.4-alkynyl, C.sub.2-C.sub.4-haloalkynyl, C.sub.1-C.sub.3-alkoxy, C.sub.1-C.sub.3-haloalkoxy, C.sub.1-C.sub.3-alkylcarbonyl, C.sub.1-C.sub.3-alkylcarbamoyl, C.sub.1-C.sub.3-alkylsulfonyl, or C.sub.1-C.sub.3-haloalkylsulfanyl.

9. A composition comprising a compound as defined in any one of claims 1 to 8, one or more auxiliaries and diluent, and optionally one more other active ingredient.

10. A method (i) of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound as defined as defined in any one of claims 1 to 8 or a composition as defined claim 9; or (ii) for the protection of plant propagation material from the attack by insects, acarines, nematodes or molluscs, which comprises treating the propagation material or the site, where the propagation material is planted, with an effective amount of a compound as defined in any one of claims 1 to 8 or a composition as defined claim 9; or (iii) of controlling parasites in or on an animal in need thereof comprising administering an effective amount of a compound as defined in any one of claims 1 to 8 or a composition as defined claim 9.

11. A plant propagation material, such as a seed, comprising, or treated with or adhered thereto, a compound as defined in any one of claims 1 to 8 or a composition as defined claim 9.

12. A compound of formula XI-a ##STR00062## wherein R.sup.1, R.sup.3, X and Y are defined in claim 1; a compound of XI-b ##STR00063## wherein R.sup.1, R.sup.3, and A are defined in claim 1; a compound of XII-a ##STR00064## wherein R.sup.1, R.sup.3, X and Y are defined in claim 1, and LG.sup.2 is chloro, bromo or fluoro; or a compound of XII-b ##STR00065## wherein R.sup.1, R.sup.3, and A are defined claim 1, and LG.sup.2 is chloro, bromo or fluoro.

Description

PREPARATORY EXAMPLES

LCMS Methods:

Method 1:

[0448] Spectra were recorded on a Mass Spectrometer from Waters (SQD Single quadrupole mass spectrometer) equipped with an electrospray source (Polarity: positive or negative ions, Full Scan, Capillary: 3.00 kV, Cone range: 41 V, Source Temperature: 150? C., Desolvation Temperature: 500? C., Cone Gas Flow: 50 L/Hr, Desolvation Gas Flow: 1000 L/Hr, Mass range: 110 to 800 Da) and a H-Class UPLC from Waters: Quaternary pump, heated column compartment and diode-array detector. Column: Acquity UPLC HSS T3 C18, 1.8 ?m, 30?2.1 mm, Temp: 40? C., DAD Wavelength range (nm): 200 to 400, Solvent Gradient: A=water+5% Acetonitrile+0.1% HCOOH, B=Acetonitrile+0.05% HCOOH: gradient: 0 min 10% B; 0.-0.2 min 10-50% B; 0.2-0.7 min 50-100% B; 0.7-1.3 min 100% B; 1.3-1.4 min 100-10% B; 1.4-1.6 min 10% B; Flow (mL/min) 0.6.

Method 2:

[0449] Spectra were recorded on a Mass Spectrometer from Agilent Technologies (6410 Triple Quadrupole mass spectrometer) equipped with an equipped with an electrospray source (Polarity: positive or negative ions, MS2 Scan, Capillary: 4.00 kV, Fragmentor: 100 V, Desolvatation Temperature: 350? C., Gas Flow: 11 L/min, Nebulizer Gas: 45 psi, Mass range: 110 to 1000 Da) and a 1200 Series HPLC from Agilent: quaternary pump, heated column compartment and diode-array detector. Column: KINETEX EVO C18, 2.6 ?m, 50?4.6 mm, Temp: 40? C., DAD Wavelength range (nm): 210 to 400, Solvent Gradient: A=95% (water+0.1% HCOOH): 5% Acetonitrile, B=Acetonitrile with 0.1% HCOOH: gradient: 0 min 10% B; 0.9-1.8 min 100% B; 1.8-2.2 min 100-10% B; 2.2-2.5 min 10% B, Flow rate (mL/min) 1.8.

Method 3:

[0450] Spectra were recorded on a Mass Spectrometer from Waters (Acquity QDa Mass Spectrometer) equipped with an electrospray source (Polarity: Positive and Negative Polarity Switch), Capillary: 0.8 kV, Cone range: 25 V, Extractor: V (No extractor voltage for QDa detector) Source Temperature: 120? C., Desolvation Temperature: 600? C., Cone Gas Flow: 50 L/h, Desolvation Gas Flow: 1000 L/h, Mass range: 110 to 850 Da) and an Acquity UPLC from Waters: Quaternary solvent manager, heated column compartment, diode-array detector. Column: Waters UPLC HSS T3, 1.8 ?m, 30?2.1 mm, Temp: 40? C., PDA Wavelength range (nm): 230 to 400, Solvent Gradient: A=Water with 0.1% formic acid: Acetonitrile: 95: 5 v/v, B=Acetonitrile with 0.05% formic acid: Gradient: 0 min-1.0 min, 10% B-90% A; 1.0 min-4.50 min 10%-100% B; 4.51 min-5.30 min, 100% B, 0% A; 5.31 min-5.50 min 100%-10% B; 5.51 min-6.00 min, 10% B, 90% A; Flow (ml/min) 0.6.

Method 4:

[0451] Spectra were recorded on a Mass Spectrometer from Agilent Technologies (6410 Triple Quadrupole mass spectrometer) equipped with an electrospray source (Polarity: positive or negative ions, MS2 Scan, Capillary: 7.00 kV, Fragmentor: 120 V, Desolvatation Temperature: 350? C., Gas Flow: 11 L/min, Nebulizer Gas: 40 psi, Mass range: 110 to 1000 Da) and a 1200 Series HPLC from Agilent: quaternary pump, heated column compartment and diode-array detector. Column: KINETEX EVO C18, 2.6 ?m, 50?4.6 mm, Temp: 40? C., Detector VWD Wavelength: 254 nm, Solvent Gradient: A=water+5% Acetonitrile+0.1% HCOOH, B=Acetonitrile+0.1% HCOOH: gradient: 0 min 10% B, 90% A; 0.9-1.8 min 100% B; 1.8-2.2 min 100-10% B; 2.2-2.5 min 10% B; Flow (mL/min) 1.8.

Method 5:

[0452] Spectra were recorded on a Mass Spectrometer from Waters (SQD, SQDII Single quadrupole mass spectrometer) equipped with an electrospray source (Polarity: positive and negative ions, Capillary: 3.00 kV, Cone range: 30 V, Extractor: 2.00 V, Source Temperature: 150? C., Desolvation Temperature: 350? C., Cone Gas Flow: 50 l/h, Desolvation Gas Flow: 650 l/h, Mass range: 100 to 900 Da) and an Acquity UPLC from Waters: Binary pump, heated column compartment, diode-array detector and ELSD detector. Column: Waters UPLC HSS T3, 1.8 ?m, 30?2.1 mm, Temp: 60? C., DAD Wavelength range (nm): 210 to 500, Solvent Gradient: A=water+5% MeOH+0.05% HCOOH, B=Acetonitrile+0.05% HCOOH, gradient: 10-100% B in 1.2 min; Flow (ml/min) 0.85.

Method 6:

[0453] Instrument specifications: Agilent 1100 Series LC/MSD system with DADELSD Alltech 2000ES and Agilent LC\MSD VL (G1956B), SL (G1956B) mass-spectrometer. Agilent 1200 Series LC/MSD system with DAD\ELSD Alltech 3300 and Agilent LC\MSD G6130A, G6120B mass-spectrometer.

[0454] Agilent Technologies 1260 Infinity LC/MSD system with DAD\ELSD Alltech 3300 and Agilent; LC\MSD G6120B mass-spectrometer. Agilent Technologies 1260 Infinity II LC/MSD system with DAD\ELSD G7102A 1290 Infinity II and Agilent LC\MSD G6120B mass-spectrometer. Agilent 1260 Series LC/MSD system with DAD\ELSD and Agilent LC\MSD (G6120B) mass-spectrometer. UHPLC Agilent 1290 Series LC/MSD system with DAD\ELSD and Agilent LC\MSD (G6125B) mass-spectrometer.

[0455] All the LC/MS data were obtained using positive/negative mode switching.

[0456] Column Agilent Poroshell 120 SB-C18 4.6?30 mm 2.7 ?m with UHPLC Guard Infinity Lab Poroshell 120 SB-C18 4.6?5 mm 2.7 ?m, Temperature 60 C [0457] Mobile phase Aacetonitrile: water (99:1%), 0.1% formic acid; Bwater (0.1% formic acid) Flow rate 3 ml/min [0458] Gradient: 0.01 min99% B [0459] 1.5 min0% B [0460] 2.2 min0% B [0461] 2.21 min99% B [0462] Injection volume 0.5 ?l; Ionization mode Electrospray ionization (ESI); Scan range m/z 83-1000; DAD 215 nm, 254 nm, 280 nm

Method 7:

[0463] Spectra were recorded on a Mass Spectrometer (ACQUITY UPLC) from Waters (SQD, SQDII Single quadrupole mass spectrometer) equipped with an electrospray source (Polarity: positive or negative ions, Capillary: 3.0 kV, Cone: 30V, Extractor: 3.00 V, Source Temperature: 150? C., Desolvation Temperature: 400? C., Cone Gas Flow: 60 L/hr, Desolvation Gas Flow: 700 L/hr, Mass range: 140 to 800 Da) and an Acquity UPLC from Waters: Solvent degasser, binary pump, heated column compartment and diode-array detector. Column: Waters UPLC HSS T3, 1.8 ?m, 30?2.1 mm, Temp: 60? C., DAD Wavelength range (nm): 210 to 400, Solvent Gradient: A=Water/Methanol 9:1,0.1% formic acid, B=Acetonitrile+0.1% formic acid, gradient: 0-100% B in 2.5 min; Flow (ml/min) 0.75

[0464] The following abbreviations are used in the experimental description below: s=singlet, d=doublet, t=triplet, q=quartet, m=multiplet, RT=retention time, min=minutes.

Example P1: 1-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-N-methyl-piperidine-4-sulfonamide (Compound P1.1)

[0465] ##STR00030##

Step 1: Ethyl 5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carboxylate

[0466] ##STR00031##

[0467] A solution of sodium ethoxide (1.1 eq) in ethanol (20% w/w) was added slowly at 4? C. to a suspension of 2-cyano-acetamide (5.9 g, 70.2 mmol, 1 eq) and the mixture was stirred for 15 minutes. Then a solution ethyl-2-(ethoxymethylene)-4,4,4-trifluoro-3-oxo-butanoate (17 g, 70.1 mmol) in 34 ml of ethanol was added under ice cooling. The reaction mixture was stirred 16 hours and allowed to reach room temperature. Then the reaction mixture was poured into ice-cold solution of 1 N hydrochloric acid. The resulting mixture was diluted with ice-cold water and stirred for 20 minutes. The precipitate was filtered, washed twice with ice-cold water and dried. 12.4 g of ethyl 5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carboxylate were obtained in a purity higher than 95% determined by quantitative NMR. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.29 (t, 3H), 4.29 (q, 2H), 8.27 (s, 1H).

Step 2: Ethyl 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carboxylate

[0468] ##STR00032##

[0469] To a solution of ethyl 5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carboxylate (3.00 g, 11.5 mmol) in acetone (57.7 mL) was added potassium carbonate (4.88 g, 34.6 mmol, 3 eq) and sodium iodide (364 mg, 2.31 mmol, 0.2 eq) followed by addition of 2-fluoro-5-(trifluoromethyl)-benzyl bromide (4.45 g, 17.3 mmol, 1.5 eq). The reaction mixture was stirred at 70? C. for 3 hours and cooled to room temperature. The reaction mixture was filtered an the residue was washed with acetone. The acetone solution was concentrated under vacuum and the residue was purified by combi-flash silica-gel to afford 4.55 g of ethyl 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)-pyridine-3-carboxylate as a yellow solid. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.42 (t, 3H), 4.45 (q, 2H), 5.71 (s, 2H), 7.24-7.27 (m, 1H), 7.66-7.70 (m, 1H), 7.90-7.99 (m, 1H), 8.43 (s, 1H); LC-MS (method 3): RT=1.21 min; [M+H].sup.+=437.

Step 3: 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carboxylic acid

[0470] ##STR00033##

[0471] To a solution of ethyl 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)-pyridine-3-carboxylate (4.5 g, 10.3 mmol) in THE (25.8 mL)/water (12.4 mL) was added Lithium hydroxide monohydrate (1.01 g, 41.3 mmol, 4 eq). The reaction mixture was stirred at room temperature until complete consumption of the starting material (monitored by TLC). The reaction mixture was diluted with ethyl acetate and acidified with hydrochloric acid. The phases were separated and the aqueous layer was extracted three times with ethyl acetate. The combined extracts were dried over sodium sulphate and concentrated. The residue was titurated with a small amount of dichloromethan to give 1.63 g of 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carboxylic acid as a white solid. .sup.1H-NMR [ppm] in DMSO-d.sub.6: 5.69 (s, 2H), 7.55 (t, 1H), 7.83-7.90 (m, 1H), 8.08-8.12 (m, 1H), 8.84 (s, 1H), 14.15 (br, s, 1H); LC-MS (method 3): RT=1.02 min; [M+H].sup.+=409.

Step 4: tert-Butyl 4-(methylsulfamoyl)piperidine-1-carboxylate

[0472] ##STR00034##

[0473] To a solution of tert-butyl 4-chlorosulfonylpiperidine-1-carboxylate (200 mg, 0.705 mmol) and pyridine (0.17 mL, 2.11 mmol, 3 eq) in acetonitrile (5 mL) was added a solution (8 mol/L) of methylamine in ethanol (0.705 mmol). The reaction was stirred at room temperature for 30 minutes. The reaction mixture was poured into water and extracted with ethyl acetate. The combined organic layers were washed with a 0.1 N HCl solution and saturated aqueous NaCl solution, dried over magnesium sulphate, and concentrated under reduced pressure to afford 160 mg of tert-butyl 4-(methylsulfamoyl)piperidine-1-carboxylate as a yellow solid. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.79 (s, 9H), 2.40-2.60 (m, 2H), 2.67-2-78 (m, 2H), 3.10 (s, 3H), 3.46-3.58 (m, 2H), 3.70-3.82 (m, 1H), 3.95-4.06 (m, 2H); LC-MS (method 3): RT=0.76 min; [M?H].sup.?=277.

Step 5: N-methylpiperidine-4-sulfonamide

[0474] ##STR00035##

[0475] tert-butyl 4-(methylsulfamoyl)piperidine-1-carboxylate (150 mg, 0,539 mmol) was dissolved in 1,4-dioxane (5 mL) and a solution (4 mol/L) of hydrogen chloride in 1,4-dioxane (1.08 mmol, 2.2 eq) was added. The reaction mixture was stirred at room temperature for 4 hours and then the solvent was evapourated. The crude product was used for the next step without further purification.

Step 6: 1-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-N-methyl-piperidine-4-sulfonamide (Compound P1.1)

[0476] ##STR00036##

[0477] To a solution of 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carboxylic acid (130 mg, 0.315 mmol) in ethyl acetate (15 mL) was added N-methylpiperidine-4-sulfonamide (0.3468 mmol, 1.1 eq) followed by addition of T3P coupling reagent (0.34 mL of a 50% solution in ethyl acetate, 0.5675 mmol, 1.8 eq) and N,N-diisopropyl-ethylamine (0.27 mL, 1.58 mmol, 5 eq). The reaction mixture was stirred at room temperature for one hour. The reaction was quenched with a solution of NaHCO.sub.3 and extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, dried over magnesium sulphate and concentrated under reduced pressure. The residue was purified with Combiflash (cyclohexane/ethylacetate 100%/0%->0%/100%) to afford 95 mg of 1-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-N-methyl-piperidine-4-sulfonamide as a white solid.

[0478] .sup.1H-NMR [ppm] in CDCl.sub.3: 1.64-1.98 (m, 2H), 2.04-2.18 (m, 1H), 2.23-2.33 (m, 1H), 2.78-3.00 (m, 1H), 2.82 and 2.84 (2 s, 3H), 3.01-3.23 (m, 2H), 3.51 (t, 1H), 4.00-4.10 (m, 1H), 4.83 (dd, 1H), 5.65 (s, 2H), 7.21-7.32 (m, 1H), 7.64-7.73 (m, 1H), 7.87-7.95 (m, 1H), 7.94 and 8.01 (2 s, 1H). LC-MS (method 3): RT=1.02 min; [M+H].sup.+=569.

Example P2: 1-[5-Cyano-6-[(2,2-difluoro-1,3-benzodioxol-5-yl)methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-N,N-dimethyl-piperidine-4-sulfonamide (compound P1.24)

[0479] ##STR00037##

Step 1: 5-Cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carboxylic acid

[0480] ##STR00038##

[0481] Ethyl 5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carboxylate (27.5 g, 106 mmol; Example P1, step 1) was dissolved in ethanol (846 mL) and potassium hydroxide (20.9 g, 19.9 mL, 317 mmol, 3.0 eq) dissolved in ethanol (211 mL) was added. The reaction mixture was stirred under reflux for 20 hours. Then the reaction mixture was diluted with ethyl acetate and 2 N hydrochloric acid. The mixture was extracted three times with ethyl acetate. The combined organic layer was washed two times with water and once with brine, dried over sodium sulfate and the solvent was removed. 24.0 g of 5-cyano-6-hydroxy-2-(trifluoromethyl)-pyridine-3-carboxylic acid were obtained as a yellow solid. .sup.1H-NMR [ppm] in DMSO-d.sub.6: 8.69 (s, 1H), 13.85 (broad s, 2H). LC-MS (method 2): RT=0.24 min; [M+H].sup.+=233.

Step 2: 1-[5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carbonyl]-N,N-dimethyl-piperidine-4-sulfonamide

[0482] ##STR00039##

[0483] To a solution of 5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carboxylic acid (1.40 g, 5.7 mmol) and N,N-dimethylpiperidin-1-ium-4-sulfonamide chloride (1.50 g, 6.3 mmol, 1.1 eq) in DMF (14 mL) was added N,N-diisopropyl-ethylamine (3.0 mL, 2.20 g, 17 mmol, 3.0 eq) followed by the addition of the coupling reagent HATU (2.7 g, 6.9 mmol, 1.2 eq). The reaction mixture was stirred at room temperature for 12 hours. Then the mixture was concentrated under vacuum to dryness and the residue was purified by RP chromatography (MeCN/water 10 to 80%) and subsequent tituration with petroleum ether to give 1.80 g of 1-[5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carbonyl]-N,N-dimethyl-piperidine-4-sulfonamide. .sup.1H-NMR [ppm] in DMSO-d.sub.6: 1.30-1.50 (m, 1H), 1.59-1.74 (m, 1H), 1.76-1.90 (m, 1H), 1.98-2.08 (m, 1H), 2.82 (s, 3H), 2.85 (s, 3H), 3.05-3.22 (m, 1H), 3.45-3.75 (m, 3H), 4.50-4.60 (m, 1H), 8.28, 8.44 (2 broad s, 1H).

Step 3: 1-[5-Cyano-6-[(2,2-difluoro-1,3-benzodioxol-5-yl)methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-N,N-dimethyl-piperidine-4-sulfonamide (compound P1.24)

[0484] ##STR00040##

[0485] To solution of 1-[5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carbonyl]-N,N-dimethyl-piperidine-4-sulfonamide (250 mg, 0.584 mmol) in acetonitrile (2.5 mL) was added cesium carbonate (381 mg, 1.17 mmol, 2.0 eq) and 5-(chloromethyl)-2,2-difluoro-1,3-benzodioxole (254 mg, 1.17 mmol, 2.0 eq). The reaction mixture was heated at 70? C. for 3 hours. The reaction mixture was quenched with water and extracted with ethyl acetate. The organic layer was extracted with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified via combiflash (10-80% ethylacetate/cyclohexane) to afford 191 mg of 1-[5-Cyano-6-[(2,2-difluoro-1,3-benzodioxol-5-yl)methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-N,N-dimethyl-piperidine-4-sulfonamide. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.58-1.90 (m, 2H), 1.92-2.06 (m, 1H), 2.12-2.20 (broad d, 1H), 2.78-2.95 (m, 1H), 2.91 (s, 3H), 2.92 (s, 3H), 3.03-3.20 (m, 1H), 3.22 (broad t, 1H), 3.41-3.55 (m, 1H), 4.75 (broad t, 1H), 5.52 (s, 2H), 7.09 (d, 1H), 7.25-7.45 (m, 2H), 8.00 and 8.12 (2 s, 1H). LC-MS (method 1): RT=1.11 min; [M+H].sup.+=577.

Example P3: 2-[1-[5-Cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-4-piperidyl]-N,N-dimethyl-acetamide (compound P1.37)

[0486] ##STR00041##

Step 1: tert-Butyl 4-(2-ethoxy-2-oxo-ethylidene)piperidine-1-carboxylate

[0487] ##STR00042##

[0488] A mixture of tert-butyl 4-oxopiperidine-1-carboxylate (20.0 g, 100.4 mmol) and ethyl 2-(triphenyl-lambda5-phosphanylidene)acetate (35.0 g, 100.5 mmol) in toluene (400 mL) were refluxed for 24 hours at 100? C. The reaction mixture was concentrated and the residue was purified using combiflash (15-20% of ethyl acetate in cyclohexane) to afford 22.0 g of tert-butyl 4-(2-ethoxy-2-oxo-ethylidene)piperidine-1-carboxylate as white solid. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.25 (t, 3H), 1.45 (s, 9H), 2.25 (t, 2H), 2.91 (t, 2H), 3.42-3.54 (m, 4H), 4.13 (q, 2H), 5.69 (s, 1H).

Step 2: tert-Butyl 4-(2-ethoxy-2-oxo-ethyl) piperidine-1-carboxylate

[0489] ##STR00043##

[0490] To a flask was charged with palladium on carbon (10% on activated carbon; Degussa, Wet) (0.22 g, 2.0 mmol, 0.22 g) was added a solution of tert-butyl 4-(2-ethoxy-2-oxo-ethylidene)piperidine-1-carboxylate (5.00 g, 19 mmol) in methanol (50 mL), and the reaction stirred under hydrogen atmosphere (1 bar) until complete consumption of starting material. The reaction mixture was filtered through celite pad and the filtrate was concentrated under vacuum to give 5.00 g of tert-butyl 4-(2-ethoxy-2-oxo-ethyl)piperidine-1-carboxylate. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.01-1.14 (m, 2H), 1.26 (t, 3H), 1.37 (s, 9H), 1.56-1.65 (m, 2H), 1.76-1.92 (m, 1H), 2.15 (d, 2H), 2.57-2.70 (m, 2H), 3.91-4.09 (m, 2H), 4.05 (q, 2H).

Step 3: 2-(1-tert-butoxycarbonyl-4-piperidyl)acetic acid

[0491] ##STR00044##

[0492] tert-Butyl 4-(2-ethoxy-2-oxo-ethyl)piperidine-1-carboxylate (5.00 g, 18.4 mmol) was dissolved in ethanol (30 mL) and an aqueous solution sodium hydroxide (92.1 mmol, 5 eq) in water was added. The reaction mixture was stirred at 90? C. for 1 hour. The reaction mixture was cooled to room temperature and an aqueous solution of 2M hydrochloric acid was added dropwise slowly on an ice bath to adjust the pH to 2. The mixture was extracted with ethyl acetate (3 times 20 mL). The combined organic phases were washed with a saturated sodium chloride solution (20 mL), dried over anhydrous sodium sulfate, and concentrated to afford 4.20 g of 2-(1-tert-butoxycarbonyl-4-piperidyl)acetic acid. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.17 (qd, 2H), 1.44 (s, 9H), 1.65 (broad d, 2H), 1.81-2.00 (m, 1H), 2.27 (d, 2H), 2.72 (broad t, 2H), 4.08 (broad s, 2H), 9.92-10.88 (broad s, 1H).

Step 4: tert-butyl 4-[2-(dimethylamino)-2-oxo-ethyl]piperidine-1-carboxylate

[0493] ##STR00045##

[0494] 2-(1-tert-butoxycarbonyl-4-piperidyl)acetic acid (1.50 g, 6.2 mmol) and triethylamine (0.95 g, 1.3 mL, 9.2 mmol, 1.5 eq) were dissolved in tetrahydrofuran (28 mL) and cooled to ?10C. Isobutylchloro-formate (1.30 g, 1.2 mL, 9.2 mmol, 1.5 eq) was added slowly and the reaction mixture was stirred at 10? C. for 15 minutes. Dimethylamine (20 mmol, 2.0 mol/L, 3.2 eq) was subsequently added and the mixture was stirred at room temperature for 16 hours. The reaction mixture was quenched with a saturated aqueous solution of NaHCO.sub.3and extracted with ethyl acetate (3 times 20 mL). The combined organic extracts were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give the crude tert-butyl 4-[2-(dimethylamino)-2-oxo-ethyl]piperidine-1-carboxylate. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.12 (qd, 2H), 1.41 (s, 9H), 1.69 (broad d, 2H), 1.90-2.03 (m, 1H), 2.18-2.25 (m, 2H), 2.69 (broad t, 2H), 2.91 (s, 3H), 2.97 (s, 3H), 4.05 (broad s, 2H).

Step 5: N,N-dimethyl-2-(4-piperidyl)acetamide (HCl salt)

[0495] ##STR00046##

[0496] To a solution of tert-butyl 4-[2-(dimethylamino)-2-oxo-ethyl]piperidine-1-carboxylate (540 mg, 2.00 mmol) in 1,4-dioxane (2 mL) was added a solution of hydrogen chloride in 1,4-dioxane (9.985 mmol, 4 mol/L, 5 eq) and the reaction was stirred at room temperature overnight. The reaction mixture was concentrated to give the crude salt of N,N-dimethyl-2-(4-piperidyl)acetamide (400 mg). .sup.1H-NMR [ppm] in DMSO-d.sub.6: 1.40 (dq, 2H), 1.79 (br d, 2H), 1.80-2.03 (m, 1H), 2.25 (d, 2H), 2.75-2.90 (m, 2H), 2.80 (s, 3H), 2.95 (s, 3H), 3.18 (br d, 2H), 8.97 (broad s, 1H), 9.13 (broad s, 1H).

Step 6: 2-[1-[5-Cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-4-piperidyl]-N,N-dimethyl-acetamide (compound P1.37)

[0497] ##STR00047##

[0498] To a stirred solution of 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)-pyridine-3-carboxylic acid (300.0 mg, 0.7349 mmol; Example P1step 3) in ethyl acetate (7.3 mL) was added N,N-dimethyl-2-piperidin-1-ium-4-yl-acetamide chloride (198 mg, 0.955 mmol, 1.3 eq), N,N-diisopropylethylamine (0.39 mL, 2.21 mmol, 3 eq) followed by addition of a solution of T3P coupling reagent (1.31 mL, 2.21 mmol, 3 eq; 50% solution in ethyl acetate). The resulting light yellow solution was stirred at room temperature for 16 hours. Then water was added the mixture was extracted three times with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by combiflash (90% ethyl acetate in cyclohexane) to afford 150 mg of 2-[1-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]-4-piperidyl]-N,N-dimethyl-acetamide as a white solid. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.10 (dq, 1H), 1.15-1.33 (m, 1H), 1.77 (t, 1H), 1.92 (t, 1H), 2.15-2.35 (m, 3H), 2.77-2.91 (m, 1H), 2.96 (s, 3H), 3.01 (s, 3H), 3.05-3.20 (m, 1H), 3.31 (t, 1H), 4.72 (t, 1H), 5.64 (s, 2H), 7.22-7.26 (m, 1H), 7.63-7.68 (m, 1H), 7.88-7.94 (m, 2H); LC-MS (method 2): RT=1.45 min; [M+HP]=561, m.p.: 143-145? C.

Example P4: 2-[4-[5-Cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]-N,N-dimethyl-acetamide (compound P2.6)

[0499] ##STR00048##

Step 1: tert-Butyl 4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazine-1-carboxylate

[0500] ##STR00049##

[0501] To a solution of 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carboxylic acid (1.00 g, 2.45 mmol) in ethyl acetate (36.7 mL) was added 1-BOC-pipperazine (0.684 g, 3.67 mmol, 1.50 eq), followed by addition of the coupling reagent T3P as a 50% solution in ethyl acetate (2.81 g, 2.63 mL, 4.41 mmol, 1.80 eq) and N,N-diisopropylethylamine (1.58 g, 2.13 mL, 12.2 mmol, 5.00 eq). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was diluted with a saturated solution of NaHCO.sub.3 and water, and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified via Combiflash to afford 1.01 g of tert-butyl 4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazine-1-carboxylate as a white solid. .sup.1H-NMR [ppm] in CDCl.sub.3: 1.48 (s, 9H), 3.19 (t, 2H), 3.35-3.43 (m, 2H), 3.45-3.62 (m, 2H), 3.64-3.73 (m, 1H), 3.80-3.89 (m, 1H), 5.67 (s, 2H), 7.23-7.30 (m, 1H), 7.64-7.72 (m, 1H), 7.91 (dd, 1H), 7.96 (s, 1H). LC-MS (method 3): RT=1.19 min; [M+H].sup.+=577.

Step 2: 2-[[2-Fluoro-5-(trifluoromethyl)phenyl]methoxy]-5-(piperazine-1-carbonyl)-6-(trifluoromethyl)pyridine-3-carbonitrile

[0502] ##STR00050##

[0503] To a solution of tert-butyl 4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazine-1-carboxylate (4.57 g, 7.93 mmol) in dioxane (30 mL) was added a solution of hydrochloric acid (4.0 mol/L in dioxane) under cooling. The reaction mixture was stirred at room temperature overnight. Then the reaction mixture was diluted with methanol and treated with basic resin until the pH was basic. The mixture was filtered and the filtrate was concentrated in vacuo to obtain 3.86 g of 2-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-5-(piperazine-1-carbonyl)-6-(trifluoromethyl)pyridine-3-carbonitrile as a pale brown solid. .sup.1H-NMR [ppm] in DMSO-d.sub.6: 2.60-2.72 (m, 2H), 2.74-2.84 (m, 1H), 3.02-3.22 (m, 2H), 3.40-3.75 (m, 3H), 5.64 (s, 2H), 7.54 (t, 1H), 7.82-7.92 (m, 1H), 8.06 (dd, 1H), 8.65 (s, 1H).

Step 3: Methyl 2-[4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]acetate

[0504] ##STR00051##

[0505] To a solution of 2-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-5-(piperazine-1-carbonyl)-6-(trifluoromethyl)pyridine-3-carbonitrile (600 mg, 1.20 mmol) in acetonitrile (10 mL) and potassium carbonate (253 mg, 1.80 mmol, 1.5 eq) and methyl bromoacetate (226 mg, 1.44 mmol, 1.2 eq) were added at 0? C. The reaction mixture was stirred at room temperature overnight, then quenched with water (20 mL) and extracted with ethyl acetate (3 times10 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to obtain 656 mg of crude methyl 2-[4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]acetate as an off-white solid. .sup.1H-NMR [ppm] in CDCl.sub.3: 2.48-2.60 (m, 2H), 3.60-2.75 (m, 2H), 3.18-3.32 (m, 1H), 3.30 (s, 2H), 3.62-3.92 (m, 3H), 3.75 (s, 3H), 5.66 (s, 2H), 7.26 (t, 1H), 7.62-7.71 (m, 1H), 7.90 (dd, 1H), 7.96 (s, 1H).

Step 4: 2-[4-[5-Cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]acetic acid

[0506] ##STR00052##

[0507] To solution of methyl 2-[4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]acetate (650 g, 1.067 mmol) in tetrahydrofuran (6 mL) was added a solution of lithium hydroxide monohydrate (71 mg, 1.60 mmol, 1.50 eq) in water (2 mL) at 10? C. The reaction mixture was stirred at room temperature for 12 hours. After completion, the reaction mixture was concentrated in vacuo, acidified with an aqueous 1 N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. .sup.1H-NMR [ppm] in DMSO-d.sub.6: 2.90-3.07 (m, 1H), 3.20-3.45 (m, 2H), 3.43-3.65 (m, 3H), 3.75-4.10 (m, 4H), 5.66 (s, 2H), 7.55 (t, 1H), 7.82-7.93 (m, 1H), 8.07 (dd, 1H), 8.73 (s, 1H).

Step 5: 2-[4-[5-Cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]-N,N-dimethyl-acetamide (compound P2.6)

[0508] ##STR00053##

[0509] To a solution of 2-[4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]acetic acid (330 mg, 0.556 mmol) in ethyl acetate (6.6 mL) was added N,N-diisopropylethylamine (145 mg, 1.11 mmol, 2 eq) under stirring followed by addition of a solution of dimethylamine in ethanol (0.6113 mmol, 1.1 eq) and the coupling reagent T3P (1.67 mmol, 3 eq; 50% in ethylacetate). The reaction mixture was stirred at room temperature overnight. After the completion of the reaction the reaction mixture was quenched with saturated aqueous NaHCO.sub.3 solution (10 mL) and extracted with ethyl acetate (3 times 20 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude material was purified by combiflash (50-100% ethyl acetate: cyclohexane) to afford 150 mg of 2-[4-[5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(trifluoromethyl)pyridine-3-carbonyl]piperazin-1-yl]-N,N-dimethyl-acetamide as a white solid. .sup.1H-NMR [ppm] in CDCl.sub.3: 2.42-2.58 (m, 2H), 2.58-2.74 (m, 2H), 2.96 (s, 3H), 3.05 (s, 3H), 3.20-3.32 (m, 4H), 3.76-3.94 (m, 2H), 5.65 (s, 2H), 7.25 (t, 1H), 7.61-7.70 (m, 1H), 7.89 (d, 1H), 7.94 (s, 1H). LC-MS (method 1): RT=1.00 min; [M+H].sup.+=562.

[0510] The compounds in Tables P1 were prepared as described in the examples above or similar methodology.

Table P1: Compounds of Formula (I-c)

[0511] ##STR00054##

[0512] The compounds in Table P1 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes.

TABLE-US-00012 TABLE P1 Comp. LC-MS No Y R.sup.3 R.sup.5 [M + H].sup.+ RT (min) Method P1.1 methylsulfamoyl CF.sub.3 2-F, 5-CF.sub.3 569 1.02 5 P1.2 dimethylsulfamoyl CF.sub.3 2-F, 5-CF.sub.3 583 1.12 1 P1.3 methylsulfonyloxy CF.sub.3 2-F, 5-CF.sub.3 570 1.06 5 P1.4 methylsulfonyloxy CHF.sub.2 2-F, 5-CF.sub.3 552 1.03 5 P1.5 dimethylsulfamoyl CH.sub.3 2-F, 5-CF.sub.3 529 1.12 1 P1.6 dimethylsulfamoyl CHF.sub.2 2-F, 5-CF.sub.3 565 1.12 1 P1.7 methylsulfamoyl CH.sub.3 2-F, 5-CF.sub.3 515 1.09 1 P1.8 methylsulfamoyl CHF.sub.2 2-F, 5-CF.sub.3 551 1.09 1 P1.9 (2-methoxy- CF.sub.3 2-F, 5-CF.sub.3 563 1.28 6 acetyl)amino P1.10 ethylsulfonylamino CF.sub.3 2-F, 5-CF.sub.3 582.9 1.38 6 P1.11 Dimethylcarbamoyl- CF.sub.3 2-F, 5-CF.sub.3 562 1.50 6 amino P1.12 acetamidomethyl CF.sub.3 2-F, 5-CF.sub.3 547.4 1.30 6 P1.13 methylcarbamoyl- CF.sub.3 2-F, 5-CF.sub.3 548 1.35 6 amino P1.14 2-(methylamino)-2- CF.sub.3 2-F, 5-CF.sub.3 547 1.38 6 oxo-ethyl P1.15 methanesulfon- CF.sub.3 2-F, 5-CF.sub.3 583 1.46 6 amidomethyl P1.16 methyl(methyl- CF.sub.3 4-OCF.sub.3 581 1.09 5 sulfonyl)amino P1.17 methyl(methyl- CH.sub.3 3-CF.sub.3 511 1.42 2 sulfonyl)amino P1.18 methyl(methyl- CH.sub.3 3-OCF.sub.2O-4 523 1.44 2 sulfonyl)amino P1.19 methanesulfon- CH.sub.3 2-Cl-5-CF.sub.3 545 1.45 2 amidomethyl P1.20 methyl(methyl- CH.sub.3 2-F, 5-CF.sub.3 529 1.43 2 sulfonyl)amino P1.21 methyl(methyl- CH.sub.3 4-OCF.sub.3 527 1.45 2 sulfonyl)amino P1.22 dimethylsulfamoyl CF.sub.3 3,4-F.sub.2 533 1.13 1 P1.23 dimethylsulfamoyl CF.sub.3 2,4,5-F.sub.3 551 1.09 1 P1.24 dimethylsulfamoyl CF.sub.3 3-OCF.sub.2O-4 577 1.11 1 P1.25 dimethylsulfamoyl CF.sub.3 2-Cl, 5-CF.sub.3 599 1.13 1 P1.26 dimethylsulfamoyl CF.sub.3 4-OCF.sub.3 581 1.12 1 P1.27 dimethylsulfamoyl CF.sub.3 2,5-Cl.sub.2 565 1.19 1 P1.28 dimethylsulfamoyl CF.sub.3 3,4-Cl.sub.2 565 1.18 1 P1.29 methylsulfamoyl-amino CF.sub.3 2-F, 5-CF.sub.3 584 1.13 1 P1.30 methyl(methyl- CF.sub.3 2-F, 5-CF.sub.3 598 1.16 1 sulfamoyl)amino P1.31 2-ethoxy-2-oxo-ethyl CF.sub.3 2-F, 5-CF.sub.3 562 1.53 2 P1.32 dimethylsulfamoyl CF.sub.3 3-CF.sub.3 565 1.15 1 P1.33 dimethylsulfamoyl CF.sub.3 3-CF.sub.3 565 1.15 1 P1.34 methyl(methyl- CH.sub.3 2,4,5-F.sub.3 497 1.39 2 sulfonyl)amino P1.35 dimethylsulfamoyl CF.sub.3 2-F, 5-CF.sub.3 612 1.17 1 (methyl)amino P1.36 dimethylsulfamoyl CF.sub.3 2-F, 5-CF.sub.3 598 1.17 1 amino P1.37 2-(dimethylamino)-2- CF.sub.3 2-F, 5-CF.sub.3 561 1.45 2 oxo-ethyl P1.38 2-(dimethylamino)-2- CHF.sub.2 2-F, 5-CF.sub.3 543 1.12 1 oxo-ethyl P1.39 methyl(methyl- CH.sub.3 3,4-F.sub.2 479 1.42 2 sulfonyl)amino P1.40 methyl(methyl- CH.sub.3 3,4-Cl.sub.2 511 1.45 2 sulfonyl)amino P1.41 methyl(methyl- CH.sub.3 2,5-Cl.sub.2 511 1.45 2 sulfonyl)amino P1.42 [methyl(methyl- CF.sub.3 2-F, 5-CF.sub.3 597 1.15 1 sulfonyl)amino]-methyl P1.43 [acetyl(methyl)- CF.sub.3 2-F, 5-CF.sub.3 561 1.11 1 amino]methyl P1.44 sulfamoyl CF.sub.3 2-F, 5-CF.sub.3 555 1.11 1 P1.45 ethylsulfamoyl CF.sub.3 2-F, 5-CF.sub.3 583 1.14 1 P1.46 2-(dimethylamino)-2- CF.sub.3 2-F, 5-CF.sub.3 577 1.44 2 oxo-ethoxy P1.47 sulfamoylmethyl CF.sub.3 2-F, 5-CF.sub.3 569 1.07 1 P1.48 methylsulfamoyl- CF.sub.3 2-F, 5-CF.sub.3 583 1.09 1 methyl P1.49 ethylsulfamoyl-methyl CF.sub.3 2-F, 5-CF.sub.3 597 1.17 1 P1.50 dimethylsulfamoyl- CF.sub.3 2-F, 5-CF.sub.3 597 1.09 1 methyl P1.51 1-(cyanocyclo- CF.sub.3 2-F, 5-CF.sub.3 571 1.51 2 propyl)methoxy P1.52 ethyl(methyl)- CF.sub.3 2-F, 5-CF.sub.3 597 1.11 1 sulfamoyl P1.53 [ethyl(methyl)- CF 2-F, 5-CF.sub.3 611 1.21 1 sulfamoyl]methyl P1.54 methylsulfonyl- CF.sub.3 2-F, 5-CF.sub.3 584 1.47 2 methoxy P1.55 cyanomethoxy CF.sub.3 2-F, 5-CF.sub.3 531 1.50 2 P1.56 2-amino-2-oxo-ethyl CF.sub.3 2-F, 5-CF.sub.3 533 1.10 1 P1.57 2-cyano-ethyl CF.sub.3 2-F, 5-CF.sub.3 529 1.53 2 P1.58 cyano-methyl CF.sub.3 2-F, 5-CF.sub.3 515 1.51 2 P1.59 [ethyl(methyl- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 581 1.14 1 sulfonyl)amino]methyl P1.60 [acetyl(ethyl)amino- CF.sub.3 2-F, 5-CF.sub.3 575 1.09 1 methyl P1.61 (propanoylamino)- CF.sub.3 2-F, 5-CF.sub.3 561 1.19 1 methyl P1.62 isopropylsulfonyl CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 552 1.05 1 P1.63 dimethylsulfamoyl CHF.sub.2 3,4-F.sub.2 515 1.11 1 P1.64 ethylsulfonyl CF.sub.3 2-F, 5-CF.sub.3 568 1.48 4 P1.65 dimethylsulfamoyl CHF.sub.2 2,4,5-F.sub.3 533 1.13 3 P1.66 dimethylsulfamoyl CHF.sub.2 3-OCF.sub.2O-4 559 1.08 1 P1.67 dimethylsulfamoyl CHF.sub.2 2,5-Cl.sub.2 547 1.1 1 P1.68 dimethylsulfamoyl CHF.sub.2 3,4-Cl.sub.2 547 1.11 1 P1.69 [methyl(propanoyl) CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 545 1.15 1 amino]methyl P1.70 dimethylsulfamoyl CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 553 1.48 4 P1.71 ethylsulfamoyl CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 553 1.15 3 P1.72 acetamidomethyl CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 517 1.11 3 P1.73 ethylsulfamoyl CHF.sub.2 3-OCF.sub.2O-4 559 1.13 3 P1.74 ethyl(methyl)- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 567 1.5 4 sulfamoyl P1.75 ethyl(methyl)- CHF.sub.2 3-OCF.sub.2O-4 573 1.15 3 sulfamoyl P1.76 dimethylsulfamoyl CHF.sub.2 4-OCF.sub.3 563 1.18 3 P1.77 methylsulfamoyl CHF.sub.2 3-OCF.sub.2O-4 545 1.45 4 P1.78 acetamidomethyl CHF.sub.2 3-OCF.sub.2O-4 523 1.44 4 P1.79 2-(methane CHF.sub.2 3-OCF.sub.2O-4 573.19 1.57 7 sulfonamido)ethyl P1.80 cyclopropylsulfonyl- CHF.sub.2 3-OCF.sub.2O-4 571.17 1.57 7 amino P1.81 (3-methyl-1,2,4- CHF.sub.2 3-OCF.sub.2O-4 548.2 1.71 7 oxadiazol-5-yl)methyl P1.82 (5-methyl-1,2,4- CHF.sub.2 3-OCF.sub.2O-4 548.2 1.7 7 oxadiazol-3-yl)methyl P1.83 (methylcarbamoyl- CHF.sub.2 3-OCF.sub.2O-4 538.22 1.45 7 amino)methyl P1.84 [methyl(methyl- CHF.sub.2 3-OCF.sub.2O-4 552.23 1.52 7 carbamoyl)amino]methyl P1.85 (dimethylcarbamoyl- CHF.sub.2 3-OCF.sub.2O-4 552.23 1.52 7 amino)methyl P1.86 [dimethylcarbamoyl CHF.sub.2 3-OCF.sub.2O-4 566.25 1.65 7 (methyl)amino]methyl P1.87 2-[methyl(methyl- CHF.sub.2 3-OCF.sub.2O-4 587 1.07 5 sulfonyl)amino]ethyl P1.88 methyl(methylsulfonyl) CF.sub.3 3-OCF.sub.2O-4 577 1.08 5 amino P1.89 dimethylsulfamoyl CHF.sub.2 2-Cl, 4-OCF.sub.2O-5 593 1.18 1 P1.90 2-(dimethylamino)-2- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 547 1.09 3 oxo-ethoxy P1.91 2-(dimethylamino)-2- CHF.sub.2 3-OCF.sub.2O-4 537 1.14 3 oxo-ethyl P1.92 2-(methylamino)-2- CHF.sub.2 3-OCF.sub.2O-4 523 1.1 3 oxo-ethyl P1.93 ethylsulfamoyl CHF.sub.2 2-Cl, 4-OCF.sub.2O-5 593 1.52 4 P1.94 methylsulfamoyl CH.sub.2OCH.sub.3 2-Cl, 4-OCF.sub.2O-5 573 1.16 1 P1.95 dimethylsulfamoyl CH.sub.2OCH.sub.3 2-Cl, 4-OCF.sub.2O-5 587 1.53 4 P1.96 2-(dimethylamino)-1,1- CHF.sub.2 3-OCF.sub.2O-4 581.23 1.71 7 dimethyl-2-oxo-ethoxy P1.97 1,1-dimethyl-2- CHF.sub.2 3-OCF.sub.2O-4 567.2 1.62 7 (methylamino)-2-oxo- ethoxy P1.98 2-acetamidoethyl CHF.sub.2 3-OCF.sub.2O-4 537.2 1.51 7 P1.99 ethyl(methyl)- CHF.sub.2 2-Cl, 4-OCF.sub.2O-5 607 1.2 1 sulfamoyl P1.100 ethylsulfamoyl CH.sub.2OCH.sub.3 2-Cl, 4-OCF.sub.2O-5 587 1.22 3 P1.101 2-(methylamino)-2- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 533 1.03 1 oxo-ethoxy P1.102 ethyl(methyl)- CH.sub.2OCH.sub.3 2-Cl, 4-OCF.sub.2O-5 601 1.22 3 sulfamoyl P1.103 2-(dimethylamino)-2- CHF.sub.2 2-Cl, 4-OCF.sub.2O-5 57 1.28 3 oxo-ethyl P1.104 2-(dimethylamino)-2- CH.sub.2OCH.sub.3 2-Cl, 4-OCF.sub.2O-5 565 1.18 3 oxo-ethyl P1.105 methylsulfamoyl CHF.sub.2 2-Cl, 4-OCF.sub.2O-5 579 1.06 3 P1.106 methylsulfamoyl CH.sub.2OCH.sub.3 3-F, 4-Br 555 0.96 3 P1.107 2-(methylamino)-2- CHF.sub.2 3-OCF.sub.2O-4 539 1.05 1 oxo-ethoxy P1.108 ethyl(methyl)- CH.sub.3 3-OCF.sub.2O-4 537 1.1 1 sulfamoyl P1.109 ethyl(methyl)- CH.sub.2OCH.sub.3 3-F, 4-Br 583 1.21 3 sulfamoyl P1.110 methylsulfamoyl CH.sub.2OCH.sub.3 2-F, 5-Cl 511 1.14 3 P1.111 methylsulfamoyl CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 539 0.94 3 P1.112 dimethylsulfamoyl CH.sub.2OCH.sub.3 2-F, 5-Cl 525 1.13 3 P1.113 dimethylsulfamoyl CHF.sub.2 3-F, 4-Br 575 1.53 4 P1.114 dimethylsulfamoyl CH.sub.2OCH.sub.3 2-Cl, 5-Br 585 1.09 1 P1.115 dimethylsulfamoyl CH.sub.2OCH.sub.3 2-F, 4-Cl 525 1.5 4 P1.116 dimethylsulfamoyl CHF.sub.2 2-F, 4-Cl 531 1.51 4 P1.117 2-acetamidoethoxy CHF.sub.2 3-OCF.sub.2O-4 553.18 1.54 7 P1.118 methylsulfamoylmethyl CHF.sub.2 3-OCF.sub.2O-4 559.1 1.6 7 P1.119 2- CHF.sub.2 3-OCF.sub.2O-4 551.21 1.66 7 [acetyl(methyl)amino] ethyl P1.120 methylsulfamoyl CH.sub.2OCH.sub.3 2,4,5-F.sub.3 513 1.06 3 P1.121 methylsulfamoyl CHF.sub.2 2-F, 5-Cl 517 1.1 3 P1.122 methylsulfamoyl CH.sub.2OCH.sub.3 2-F, 4-Cl 511 1.1 3 P1.123 methylsulfamoyl CHF.sub.2 2-F, 4-Cl 517 1.12 3 P1.124 methylsulfamoyl CH.sub.2OCH.sub.3 2-Cl, 5-Br 571 1.19 3 P1.125 dimethylsulfamoyl CHF.sub.2 2-Cl, 5-Br 591 1.1 3 P1.126 dimethylsulfamoyl CHF.sub.2 3-?NON?-4 521 1.04 1 P1.127 dimethylsulfamoyl CH.sub.2OCH.sub.3 3-?NON?-4 515 1.07 3 P1.128 dimethylsulfamoyl CH.sub.2OCH.sub.3 2,4,5-F.sub.3 527 1.04 1 P1.129 dimethylsulfamoyl CHF.sub.2 2-F, 5-Cl 531 1.06 1 P1.130 methylsulfamoyl CH.sub.2OCH.sub.3 3-?NON?-4 501 0.98 1 P1.131 methylsulfamoyl CHF.sub.2 3-F, 4-Br 561 0.98 3 P1.132 dimethylsulfamoyl cyclopropyl 3-OCF.sub.2O-4 549 1.18 3 P1.133 methylsulfamoyl cyclopropyl 3-OCF.sub.2O-4 535 1.14 3 P1.134 ethyl(methyl)- cyclopropyl 3-OCF.sub.2O-4 563 1.2 3 sulfamoyl P1.135 ethylsulfamoyl cyclopropyl 3-OCF.sub.2O-4 549 1.08 1 P1.136 dimethylsulfamoyl CH.sub.2OCH.sub.3 3-F, 4-Br 569 1.16 3 P1.137 ethyl(methyl)- CHF.sub.2 2,4,5-F.sub.3 547 1.14 3 sulfamoyl P1.138 ethyl(methyl)- CH.sub.2OCH.sub.3 2,4,5-F.sub.3 541 1.07 1 sulfamoyl P1.139 ethyl(methyl)- CH.sub.2OCH.sub.3 3-?NON?-4 529 1.05 1 sulfamoyl P1.140 ethyl(methyl)- CH.sub.3 3-F, 4-Br 553 1.2 3 sulfamoyl P1.141 ethyl(methyl)- CH.sub.2OCH.sub.3 2-Cl, 5-Br 599 1.12 1 sulfamoyl P1.142 ethyl(methyl)- CH.sub.2OCH.sub.3 2-F. 5-Cl 539 1.15 3 sulfamoyl P1.143 ethyl(methyl)- CHF.sub.2 3-F, 4-Br 589 1.21 3 sulfamoyl P1.144 ethyl(methyl)- cyclopropyl 2,4,5-F.sub.3 537 1.19 3 sulfamoyl P1.145 ethyl(methyl)- CHF.sub.2 2-F. 4-Cl 545 1.2 3 sulfamoyl P1.146 ethyl(methyl)- CHF.sub.2 2-F. 5-Cl 545 1.18 3 sulfamoyl P1.147 ethyl(methyl)- cyclopropyl 3-F, 4-Br 579 1.23 3 sulfamoyl P1.148 ethyl(methyl)- cyclopropyl 3-?NON?-4 525 1.19 3 sulfamoyl P1.149 ethylsulfamoyl CHF.sub.2 2-Cl, 5-Br 59 1.19 3 P1.150 ethylsulfamoyl CH.sub.2OCH.sub.3 3-?NON?-4 515 1 3 P1.151 ethylsulfamoyl CHF.sub.2 2,4,5-F.sub.3 533 1.1 3 P1.152 methylsulfamoyl CHF.sub.2 3-?NON?-4 507 1 3 P1.153 ethylsulfamoyl CHF.sub.2 3-?NON?-4 521 1.1 3 P1.154 ethylsulfamoyl CH.sub.2OCH.sub.3 2-F. 5-Cl 525 1.14 3 P1.155 ethylsulfamoyl CH.sub.2OCH.sub.3 2-F. 4-Cl 525 1.05 1 P1.156 ethylsulfamoyl CH.sub.2OCH.sub.3 2,4,5-F.sub.3 527 1.12 3 P1.157 ethylsulfamoyl CHF.sub.2 2-F. 4-Cl 531 1.12 3 P1.158 2-(methylamino)-2- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 517 1.45 4 oxo-ethyl P1.159 ethyl(methyl)- CHF.sub.2 3-?NON?-4 535 1.12 3 sulfamoyl P1.160 ethyl(methyl)- CHF.sub.2 2-Cl, 5-Br 605 1.2 3 sulfamoyl P1.161 ethyl(methyl)- CH.sub.2OCH.sub.3 2-F. 4-Cl 539 1.09 1 sulfamoyl P1.162 ethylsulfamoyl CHF.sub.2 3-F, 4-Br 575 1.14 3 P1.163 ethylsulfamoyl CH.sub.2OCH.sub.3 3-F, 4-Br 569 1.48 4 P1.164 ethylsulfamoyl CH.sub.2OCH.sub.3 2-Cl, 5-Br 585 1.07 1 P1.165 2-(dimethylamino)-2- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 531 1.04 1 oxo-ethyl P1.166 methylsulfamoyl CH.sub.3 3-F, 4-Br 525 1.12 3 P1.167 methylsulfamoyl CH.sub.3 3-OCF.sub.2O-4 509 1.04 1 P1.168 methylsulfamoyl CHF.sub.2 2-F. 5-Cl 531 1.05 1 P1.169 ethyl(methyl)- CHF.sub.2 2-F, 5-CHF.sub.2 561 1.13 3 sulfamoyl P1.170 ethyl(methyl)- CH.sub.2OCH.sub.3 2-F, 5-CHF.sub.2 555 1.46 4 sulfamoyl

Table P2: Compounds of Formula (I-d)

[0513] ##STR00055##

[0514] The compounds in Table P1 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, m=minutes.

TABLE-US-00013 TABLE P2 Comp. LC-MS No A R.sup.3 R.sup.5 [M + H].sup.+ RT (min) Method P2.1 ethylcarbamoyl CF.sub.3 2-F, 5-CF.sub.3 548 1.01 5 P2.2 methylcarbamoyl CF.sub.3 2-F, 5-CF.sub.3 534 0.99 5 P2.3 methylcarbamoyl CH.sub.3 2-F, 5-CF.sub.3 480 0.94 5 P2.4 (1-cyano- CF.sub.3 2-F, 5-CF.sub.3 556 1.15 1 cyclopropyl)methyl P2.5 2-(methylamino)-2- CF.sub.3 2-F, 5-CF.sub.3 548 1.04 1 oxo-ethyl P2.6 2-(dimethylamino)-2- CF.sub.3 2-F, 5-CF.sub.3 562 1.00 1 oxo-ethyl P2.7 3-methoxy-propanoyl CF.sub.3 2-F, 5-CF.sub.3 563 1.07 1 P2.8 1-cyano-cyclo- CF.sub.3 2-F, 5-CF.sub.3 570 1.10 1 propanecarbonyl P2.9 2-cyanoacetyl CF.sub.3 2-F, 5-CF.sub.3 544 1.09 1 P2.10 ethylcarbamoyl CH.sub.3 2-F, 5-CF.sub.3 494 1.05 1 P2.11 2-methoxyethyl CF.sub.3 2-F, 5-CF.sub.3 535 1.04 1 P2.12 ethylcarbamoyl CHF.sub.2 2-F, 5-CF.sub.3 530 1.09 1 P2.13 1,1-dimethyl-2- CF.sub.3 2-F, 5-CF.sub.3 576 1.07 1 (methylamino)-2-oxo- ethyl P2.14 iso-propyl-carbamoyl CF.sub.3 2-F, 5-CF.sub.3 562.4 1.37 6 P2.15 2-(dimethylamino)- CF.sub.3 2-F, 5-CF.sub.3 590 1.10 1 1,1-dimethyl-2-oxo- ethyl P2.16 2-methoxy-1,1- CF.sub.3 2-F, 5-CF.sub.3 563 1.02 1 dimethyl-ethyl P2.17 2-cyano-2-methyl- CF.sub.3 2-F, 5-CF.sub.3 572 1.48 2 propanoyl P2.18 2-(ethylamino)-2- CF.sub.3 2-F, 5-CF.sub.3 562 1.36 2 oxo-ethyl P2.19 2-cyano-2-methyl- CHF.sub.2 2-F, 5-CF.sub.3 554 1.18 1 propanoyl P2.20 1-cyano-cyclo- CH.sub.3 2-F, 5-CF.sub.3 516 1.44 2 propanecarbonyl P2.21 1-cyano-cyclo- CHF.sub.2 2-F, 5-CF.sub.3 552 1.44 2 propanecarbonyl P2.22 2-[ethyl(methyl)- CF.sub.3 2-F, 5-CF.sub.3 576 1.98 2 amino]-2-oxo-ethyl P2.23 2-[diethyl-amino]-2- CF.sub.3 2-F, 5-CF.sub.3 590 1.29 2 oxo-ethyl P2.24 2-(cyclopropyl- CF.sub.3 2-F, 5-CF.sub.3 574 1.08 1 amino)-2-oxo-ethyl P2.25 tetrahydrofuran-2- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 531 1.06 1 ylmethyl P2.26 1-cyano- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 540 1.06 1 cyclopropane- carbonyl P2.27 2-(dimethylamino)-2- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 532 1.02 3 oxo-ethyl P2.28 2-[methyl(methyl- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 596 1.43 4 sulfonyl)amino]acetyl P2.29 2-(methane- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 582 1.4 4 sulfonamido)acetyl P2.30 (5-chlorothiazol-2- CHF.sub.2 3-OCF.sub.2O-4 584.13 1.73 7 yl)methyl P2.31 (5-methyl-1,2,4- CHF.sub.2 3-OCF.sub.2O-4 549.21 1.55 7 oxadiazol-3-yl)methyl P2.32 2-[ethyl(methyl)- CHF.sub.2 3-OCF.sub.2O-4 552 1.05 1 amino]-2-oxo-ethyl P2.33 2-(dimethylamino)-2- CHF.sub.2 3-OCF.sub.2O-4 538 1.01 1 oxo-ethyl P2.34 (2-methylthiazol-5- CHF.sub.2 3-OCF.sub.2O-4 564.16 1.39 7 yl)methyl P2.35 1- CHF.sub.2 3-OCF.sub.2O-4 564.22 1.6 7 (dimethylcarbamoyl)- cyclopropyl P2.36 1-(methylcarbamoyl)- CHF.sub.2 3-OCF.sub.2O-4 550.19 1.57 7 cyclopropyl P2.37 2-(dimethylamino)-2- CHF.sub.2 4-Br 536 0.78 5 oxo-ethyl P2.38 2-[ethyl(methyl)- CH.sub.2OCH.sub.3 3-OCF.sub.2O-4 546 1.02 3 amino]-2-oxo-ethyl P2.39 2-(dimethylamino)-2- CH.sub.3 3-OCF.sub.2O-4 502 0.85 5 oxo-ethyl P2.40 2-(dimethylamino)-2- CH.sub.3 3-F, 4-Br 518 0.77 5 oxo-ethyl P2.41 2-(dimethylamino)-2- CHF.sub.2 2-F, 5-Br 554 0.86 5 oxo-ethyl P2.42 2-(dimethylamino)-2- CHF.sub.2 2,4,5-F.sub.3 512 0.78 5 oxo-ethyl P2.43 2-(dimethylamino)-2- CHF.sub.2 3-F, 4-Br 554 0.84 5 oxo-ethyl P2.44 2-(dimethylamino)-2- CHF.sub.2 3,4-F.sub.2 494 0.82 5 oxo-ethyl P2.45 2-[ethyl(methyl)- CH.sub.2OCH.sub.3 3-F. 4-Br 562 1 3 amino]-2-oxo-ethyl P2.46 dimethylcarbamoyl CHF.sub.2 3-OCF.sub.2O-4 524.26 1.55 7 P2.47 2-amino-2-oxo-ethyl CHF.sub.2 3-OCF.sub.2O-4 510.21 1.19 7 P2.48 2-ethoxyethyl CHF.sub.2 3-OCF.sub.2O-4 525.25 1.16 7 P2.49 cyclopropylmethyl CHF.sub.2 3-OCF.sub.2O-4 507.22 1.15 7 P2.50 2-methoxyethyl CHF.sub.2 3-OCF.sub.2O-4 511.23 1.12 7 P2.51 2-amino-1-methyl-2- CHF.sub.2 3-OCF.sub.2O-4 524.23 1.2 7 oxo-ethyl P2.52 (1-cyano- CHF.sub.2 3-OCF.sub.2O-4 532.24 1.54 7 cyclopropyl)methyl P2.53 2-[ethyl(methyl)- CH.sub.2OCH.sub.3 3-?NON?-4 508 0.89 1 amino]-2-oxo-ethyl P2.54 2-[ethyl(methyl)- CHF.sub.2 2-F, 4-Cl 524 0.96 1 amino]-2-oxo-ethyl P2.55 2-[ethyl(methyl)- CHF.sub.2 2-Cl, 5-Br 584 1.00 1 amino]-2-oxo-ethyl P2.56 2-[ethyl(methyl)- CH.sub.2OCH.sub.3 2-Cl, 5-Br 578 1.00 3 amino]-2-oxo-ethyl P2.57 2-[ethyl(methyl)- cyclopropyl 3-OCF.sub.2O-4 542 1.02 3 amino]-2-oxo-ethyl P2.58 2-[ethyl(methyl)- CHF.sub.2 3-?NON?-4 514 0.93 1 amino]-2-oxo-ethyl P2.59 2-[ethyl(methyl)- CH.sub.2OCH.sub.3 2-F, 4-Cl 518 0.99 3 amino]-2-oxo-ethyl P2.60 2-[ethyl(methyl)- CH.sub.2OCH.sub.3 2,4,5-F.sub.3 520 0.95 1 amino]-2-oxo-ethyl

[0515] The activity of the compositions according to the invention can be broadened considerably, and adapted to prevailing circumstances, by adding other insecticidally, acaricidally and/or fungicidally active ingredients. The mixtures of the compounds of formula (I) with other insecticidally, acaricidally and/or fungicidally active ingredients may also have further surprising advantages which can also be described, in a wider sense, as synergistic activity. For example, better tolerance by plants, reduced phytotoxicity, insects can be controlled in their different development stages or better behaviour during their production, for example during grinding or mixing, during their storage or during their use.

[0516] Suitable additions to active ingredients here are, for example, representatives of the following classes of active ingredients: organophosphorus compounds, nitrophenol derivatives, thioureas, juvenile hormones, formamidines, benzophenone derivatives, ureas, pyrrole derivatives, carbamates, pyrethroids, chlorinated hydrocarbons, acylureas, pyridinylmethyleneamino derivatives, macrolides, neonicotinoids and Bacillus thuringiensis preparations.

[0517] The following mixtures of a compound of formula (I) with an active substances are preferred (the abbreviation TX means one compound selected from the compounds defined in Tables 1 to 57 and Tables P1 to P2): [0518] an adjuvant selected from the group of substances consisting of petroleum oils (alternative name) (628)+TX, [0519] abamectin+TX, acequinocyl+TX, acetamiprid+TX, acetoprole+TX, acrinathrin+TX, acynonapyr+TX, afidopyropen+TX, afoxolaner+TX, alanycarb+TX, allethrin+TX, alpha-cypermethrin+TX, alphamethrin+TX, amidoflumet+TX, aminocarb+TX, azocyclotin+TX, bensultap+TX, benzoximate+TX, benzpyrimoxan+TX, betacyfluthrin+TX, beta-cypermethrin+TX, bifenazate+TX, bifenthrin+TX, binapacryl+TX, bioallethrin+TX, S-bioallethrin+TX, bioresmethrin+TX, bistrifluron+TX, broflanilide+TX, brofluthrinate+TX, bromophos-ethyl+TX, buprofezine+TX, butocarboxim+TX, cadusafos+TX, carbaryl+TX, carbosulfan+TX, cartap+TX, CAS number: 1632218-00-8+TX, CAS number: 1808115-49-2+TX, CAS number: 2032403-97-5+TX, CAS number: 2044701-44-0+TX, CAS number: 2128706-05-6+TX, CAS number: 2095470-94-1+TX, CAS number: 2377084-09-6+TX, CAS number: 1445683-71-5+TX, CAS number: 2408220-94-8+TX, CAS number: 2408220-91-5+TX, CAS number: 1365070-72-9+TX, CAS number: 2171099-09-3+TX, CAS number: 2396747-83-2+TX, CAS number: 2133042-31-4+TX, CAS number: 2133042-44-9+TX, CAS number: 1445684-82-1+TX, CAS number: 1922957-45-6+TX, CAS number: 1922957-46-7+TX, CAS number: 1922957-47-8+TX, CAS number: 1922957-48-9+TX, CAS number: 2415706-16-8+TX, CAS number: 1594624-87-9+TX, CAS number: 1594637-65-6+TX, CAS number: 1594626-19-3+TX, CAS number: 1990457-52-7+TX, CAS number: 1990457-55-0+TX, CAS number: 1990457-57-2+TX, CAS number: 1990457-77-6+TX, CAS number: 1990457-66-3+TX, CAS number: 1990457-85-6+TX, CAS number: 2220132-55-6+TX, CAS number: 1255091-74-7+TX, CAS number: 1305319-70-3+TX, CAS number: 1442448-92-1+TX, CAS number: RNA (Leptinotarsa decemlineata-specific recombinant double-stranded interfering GS2)+TX, CAS number: 2719848-60-7+TX, CAS number: 1956329-03-5+TX, chlorantraniliprole+TX, chlordane+TX, chlorfenapyr+TX, chloroprallethrin+TX, chromafenozide+TX, clenpirin+TX, cloethocarb+TX, clothianidin+TX, 2-chlorophenyl N-methylcarbamate (CPMC)+TX, cyanofenphos+TX, cyantraniliprole+TX, cyclaniliprole+TX, cyclobutrifluram+TX, cycloprothrin+TX, cycloxaprid+TX, cyenopyrafen+TX, cyetpyrafen (or etpyrafen)+TX, cyflumetofen+TX, cyfluthrin+TX, cyhalodiamide+TX, cyhalothrin+TX, cypermethrin+TX, cyphenothrin+TX, cyproflanilide+TX, cyromazine+TX, deltamethrin+TX, diafenthiuron+TX, dialifos+TX, dibrom+TX, dicloromezotiaz+TX, diflovidazine+TX, diflubenzuron+TX, dimpropyridaz+TX, dinactin+TX, dinocap+TX, dinotefuran+TX, dioxabenzofos+TX, emamectin (or emamectin benzoate)+TX, empenthrin+TX, epsilon-momfluorothrin+TX, epsilon-metofluthrin+TX, esfenvalerate+TX, ethion+TX, ethiprole+TX, etofenprox+TX, etoxazole+TX, famphur+TX, fenazaquin+TX, fenfluthrin+TX, fenmezoditiaz+TX, fenitrothion+TX, fenobucarb+TX, fenothiocarb+TX, fenoxycarb+TX, fenpropathrin+TX, fenpyroximate+TX, fensulfothion+TX, fenthion+TX, fentinacetate+TX, fenvalerate+TX, fipronil+TX, flometoquin+TX, flonicamid+TX, fluacrypyrim+TX, fluazaindolizine+TX, fluazuron+TX, flubendiamide+TX, flubenzimine+TX, fluchlordiniliprole+TX, flucitrinate+TX, flucycloxuron+TX, flucythrinate+TX, fluensulfone+TX, flufenerim+TX, flufenprox+TX, flufiprole+TX, fluhexafon+TX, flumethrin+TX, fluopyram+TX, flupentiofenox+TX, flupyradifurone+TX, flupyrimin+TX, fluralaner+TX, fluvalinate+TX, fluxametamide+TX, fosthiazate+TX, gamma-cyhalothrin+TX, guadipyr+TX, halofenozide+TX, halfenprox+TX, heptafluthrin+TX, hexythiazox+TX, hydramethylnon+TX, imicyafos+TX, imidacloprid+TX, imiprothrin+TX, indazapyroxamet+TX, indoxacarb+TX, iodomethane+TX, iprodione+TX, isocycloseram+TX, isothioate+TX, ivermectin+TX, kappa-bifenthrin+TX, kappa-tefluthrin+TX, lambda-Cyhalothrin+TX, lepimectin+TX, lotilaner+TX, lufenuron+TX, metaflumizone+TX, metaldehyde+TX, metam+TX, methomyl+TX, methoxyfenozide+TX, metofluthrin+TX, metolcarb+TX, mexacarbate+TX, milbemectin+TX, momfluorothrin+TX, niclosamide+TX, nicofluprole+TX; nitenpyram+TX, nithiazine+TX, omethoate+TX, oxamyl+TX, oxazosulfyl+TX, parathion-ethyl+TX, permethrin+TX, phenothrin+TX, phosphocarb+TX, piperonylbutoxide+TX, pirimicarb+TX, pirimiphos-ethyl+TX, pirimiphos-methyl+TX, Polyhedrosis virus+TX, prallethrin+TX, profenofos+TX, profluthrin+TX, propargite+TX, propetamphos+TX, propoxur+TX, prothiophos+TX, protrifenbute+TX, pyflubumide+TX, pymetrozine+TX, pyraclofos+TX, pyrafluprole+TX, pyridaben+TX, pyridalyl+TX, pyrifluquinazon+TX, pyrimidifen+TX, pyriminostrobin+TX, pyriprole+TX, pyriproxyfen+TX, resmethrin+TX, sarolaner+TX, selamectin+TX, silafluofen+TX, spinetoram+TX, spinosad+TX, spirodiclofen+TX, spiromesifen+TX, spiropidion+TX, spirotetramat+TX, spidoxamat+TX, sulfoxaflor+TX, tebufenozide+TX, tebufenpyrad+TX, tebupirimiphos+TX, tefluthrin+TX, temephos+TX, tetrachlorantraniliprole+TX, tetradiphon+TX, tetramethrin+TX, tetramethylfluthrin+TX, tetranactin+TX, tetraniliprole+TX, theta-cypermethrin+TX, thiacloprid+TX, thiamethoxam+TX, thiocyclam+TX, thiodicarb+TX, thiofanox+TX, thiometon+TX, thiosultap+TX, tigolaner+TX, tioxazafen+TX, tolfenpyrad+TX, toxaphene+TX, tralomethrin+TX, transfluthrin+TX, triazamate+TX, triazophos+TX, trichlorfon+TX, trichloronate+TX, trichlorphon+TX, trifluenfuronate+TX, triflumezopyrim+TX, tyclopyrazoflor+TX, zeta-cypermethrin+TX, Extract of seaweed and fermentation product derived from melasse+TX, Extract of seaweed and fermentation product derived from melasse comprising urea+TX, amino acids+TX, potassium and molybdenum and EDTA-chelated manganese+TX, Extract of seaweed and fermented plant products+TX, Extract of seaweed and fermented plant products comprising phytohormones+TX, vitamins+TX, EDTA-chelated copper+TX, zinc+TX, and iron+TX, azadirachtin+TX, Bacillus aizawai+TX, Bacillus chitinosporus AQ746 (NRRL Accession No B-21 618)+TX, Bacillus firmus+TX, Bacillus kurstaki+TX, Bacillus mycoides AQ726 (NRRL Accession No. B-21664)+TX, Bacillus pumilus (NRRL Accession No B-30087)+TX, Bacillus pumilus AQ717 (NRRL Accession No. B-21662)+TX, Bacillus sp. AQ178 (ATCC Accession No. 53522)+TX, Bacillus sp. AQ175 (ATCC Accession No. 55608)+TX, Bacillus sp. AQ177 (ATCC Accession No. 55609)+TX, Bacillus subtilis unspecified+TX, Bacillus subtilis AQ153 (ATCC Accession No. 55614)+TX, Bacillus subtilis AQ30002 (NRRL Accession No. B-50421)+TX, Bacillus subtilis AQ30004 (NRRL Accession No. B 50455)+TX, Bacillus subtilis AQ713 (NRRL Accession No. B-21661)+TX, Bacillus subtilis AQ743 (NRRL Accession No. B-21665)+TX, Bacillus thuringiensis AQ52 (NRRL Accession No. B-21619)+TX, Bacillus thuringiensis BD #32 (NRRL Accession No B-21530)+TX, Bacillus thuringiensis subspec. kurstaki BMP 123+TX, Beauveria bassiana+TX, D-limonene+TX, Granulovirus+TX, Harpin+TX, Helicoverpa armigera Nucleopolyhedrovirus+TX, Helicoverpa zea Nucleopolyhedrovirus+TX, Heliothis virescens Nucleopolyhedrovirus+TX, Heliothis punctigera Nucleopolyhedrovirus+TX, Metarhizium spp.+TX, Muscodor albus 620 (NRRL Accession No. 30547)+TX, Muscodor roseus A3-5 (NRRL Accession No. 30548)+TX, Neem tree based products+TX, Paecilomyces fumosoroseus+TX, Paecilomyces lilacinus+TX, Pasteuria nishizawae+TX, Pasteuria penetrans+TX, Pasteuria ramosa+TX, Pasteuria thornei+TX, Pasteuria usgae+TX, P-cymene+TX, Plutella xylostella Granulosis virus+TX, Plutella xylostella Nucleopolyhedrovirus+TX, Polyhedrosis virus+TX, pyrethrum+TX, QRD 420 (a terpenoid blend)+TX, QRD 452 (a terpenoid blend)+TX, QRD 460 (a terpenoid blend)+TX, Quillaja saponaria+TX, Rhodococcus globerulus AQ719 (NRRL Accession No B-21663)+TX, Spodoptera frugiperda Nucleopolyhedrovirus+TX, Streptomyces galbus (NRRL Accession No. 30232)+TX, Streptomyces sp. (NRRL Accession No. B-30145)+TX, Terpenoid blend+TX, and Verticillium spp.+TX; [0520] an algicide selected from the group of substances consisting of bethoxazin [CCN]+TX, copper dioctanoate (IUPAC name) (170)+TX, copper sulfate (172)+TX, cybutryne [CCN]+TX, dichlone (1052)+TX, dichlorophen (232)+TX, endothal (295)+TX, fentin (347)+TX, hydrated lime [CCN]+TX, nabam (566)+TX, quinoclamine (714)+TX, quinonamid (1379)+TX, simazine (730)+TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347)+TX; [0521] an anthelmintic selected from the group of substances consisting of abamectin (1)+TX, crufomate (1011)+TX, cyclobutrifluram+TX, doramectin (alternative name) [CCN]+TX, emamectin (291)+TX, emamectin benzoate (291)+TX, eprinomectin (alternative name) [CCN]+TX, ivermectin (alternative name) [CCN]+TX, milbemycin oxime (alternative name) [CCN]+TX, moxidectin (alternative name) [CCN]+TX, piperazine [CCN]+TX, selamectin (alternative name) [CCN]+TX, spinosad (737) and thiophanate (1435)+TX; [0522] an avicide selected from the group of substances consisting of chloralose (127)+TX, endrin (1122)+TX, fenthion (346)+TX, pyridin-4-amine (IUPAC name) (23) and strychnine (745)+TX; a bactericide selected from the group of substances consisting of 1-hydroxy-1H-pyridine-2-thione (IUPAC name) (1222)+TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748)+TX, 8-hydroxyquinoline sulfate (446)+TX, bronopol (97)+TX, copper dioctanoate (IUPAC name) (170)+TX, copper hydroxide (IUPAC name) (169)+TX, cresol [CCN]+TX, dichlorophen (232)+TX, dipyrithione (1105)+TX, dodicin (1112)+TX, fenaminosulf (1144)+TX, formaldehyde (404)+TX, hydrargaphen (alternative name) [CCN]+TX, kasugamycin (483)+TX, kasugamycin hydrochloride hydrate (483)+TX, nickel bis(dimethyldithiocarbamate) (IUPAC name) (1308)+TX, nitrapyrin (580)+TX, octhilinone (590)+TX, oxolinic acid (606)+TX, oxytetracycline (611)+TX, potassium hydroxyquinoline sulfate (446)+TX, probenazole (658)+TX, streptomycin (744)+TX, streptomycin sesquisulfate (744)+TX, tecloftalam (766)+TX, and thiomersal (alternative name) [CCN]+TX; [0523] a biological agent selected from the group of substances consisting of Adoxophyes orana GV (alternative name) (12)+TX, Agrobacterium radiobacter (alternative name) (13)+TX, Amblyseius spp. (alternative name) (19)+TX, Anagrapha falcifera NPV (alternative name) (28)+TX, Anagrus atomus (alternative name) (29)+TX, Aphelinus abdominalis (alternative name) (33)+TX, Aphidius colemani (alternative name) (34)+TX, Aphidoletes aphidimyza (alternative name) (35)+TX, Autographa californica NPV (alternative name) (38)+TX, Bacillus firmus (alternative name) (48)+TX, Bacillus sphaericus Neide (scientific name) (49)+TX, Bacillus thuringiensis Berliner (scientific name) (51)+TX, Bacillus thuringiensis subsp. aizawai (scientific name) (51)+TX, Bacillus thuringiensis subsp. israelensis (scientific name) (51)+TX, Bacillus thuringiensis subsp. japonensis (scientific name) (51)+TX, Bacillus thuringiensis subsp. kurstaki (scientific name) (51)+TX, Bacillus thuringiensis subsp. tenebrionis (scientific name) (51)+TX, Beauveria bassiana (alternative name) (53)+TX, Beauveria brongniartii (alternative name) (54)+TX, Chrysoperla carnea (alternative name) (151)+TX, Cryptolaemus montrouzieri (alternative name) (178)+TX, Cydia pomonella GV (alternative name) (191)+TX, Dacnusa sibirica (alternative name) (212)+TX, Diglyphus isaea (alternative name) (254)+TX, Encarsia formosa (scientific name) (293)+TX, Eretmocerus eremicus (alternative name) (300)+TX, Helicoverpa zea NPV (alternative name) (431)+TX, Heterorhabditis bacteriophora and H. megidis (alternative name) (433)+TX, Hippodamia convergens (alternative name) (442)+TX, Leptomastix dactylopii (alternative name) (488)+TX, Macrolophus caliginosus (alternative name) (491)+TX, Mamestra brassicae NPV (alternative name) (494)+TX, Metaphycus helvolus (alternative name) (522)+TX, Metarhizium anisopliae var. acridum (scientific name) (523)+TX, Metarhizium anisopliae var. anisopliae (scientific name) (523)+TX, Neodiprion sertifer NPV and N. lecontei NPV (alternative name) (575)+TX, Orius spp. (alternative name) (596)+TX, Paecilomyces fumosoroseus (alternative name) (613)+TX, Phytoseiulus persimilis (alternative name) (644)+TX, Spodoptera exigua multicapsid nuclear polyhedrosis virus (scientific name) (741)+TX, Steinernema bibionis (alternative name) (742)+TX, Steinernema carpocapsae (alternative name) (742)+TX, Steinernema feltiae (alternative name) (742)+TX, Steinernema glaseri (alternative name) (742)+TX, Steinernema riobrave (alternative name) (742)+TX, Steinernema riobravis (alternative name) (742)+TX, Steinernema scapterisci (alternative name) (742)+TX, Steinernema spp. (alternative name) (742)+TX, Trichogramma spp. (alternative name) (826)+TX, Typhlodromus occidentalis (alternative name) (844) and Verticillium lecanii (alternative name) (848)+TX; [0524] a soil sterilant selected from the group of substances consisting of iodomethane (IUPAC name) (542) and methyl bromide (537)+TX; [0525] a chemosterilant selected from the group of substances consisting of apholate [CCN]+TX, bisazir (alternative name) [CCN]+TX, busulfan (alternative name) [CCN]+TX, diflubenzuron (250)+TX, dimatif (alternative name) [CCN]+TX, hemel [CCN]+TX, hempa [CCN]+TX, metepa [CCN]+TX, methiotepa [CCN]+TX, methyl apholate [CCN]+TX, morzid [CCN]+TX, penfluron (alternative name) [CCN]+TX, tepa [CCN]+TX, thiohempa (alternative name) [CCN]+TX, thiotepa (alternative name) [CCN]+TX, tretamine (alternative name) [CCN] and uredepa (alternative name) [CCN]+TX; [0526] an insect pheromone selected from the group of substances consisting of (E)-dec-5-en-1-yl acetate with (E)-dec-5-en-1-ol (IUPAC name) (222)+TX, (E)-tridec-4-en-1-yl acetate (IUPAC name) (829)+TX, (E)-6-methylhept-2-en-4-ol (IUPAC name) (541)+TX, (E,Z)-tetradeca-4,10-dien-1-yl acetate (IUPAC name) (779)+TX, (Z)-dodec-7-en-1-yl acetate (IUPAC name) (285)+TX, (Z)-hexadec-11-enal (IUPAC name) (436)+TX, (Z)-hexadec-11-en-1-yl acetate (IUPAC name) (437)+TX, (Z)-hexadec-13-en-11-yn-1-yl acetate (IUPAC name) (438)+TX, (Z)-icos-13-en-10-one (IUPAC name) (448)+TX, (Z)-tetradec-7-en-1-al (IUPAC name) (782)+TX, (Z)-tetradec-9-en-1-ol (IUPAC name) (783)+TX, (Z)-tetradec-9-en-1-yl acetate (IUPAC name) (784)+TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate (IUPAC name) (283)+TX, (9Z,11E)-tetradeca-9,11-dien-1-yl acetate (IUPAC name) (780)+TX, (9Z,12E)-tetradeca-9,12-dien-1-yl acetate (IUPAC name) (781)+TX, 14-methyloctadec-1-ene (IUPAC name) (545)+TX, 4-methylnonan-5-ol with 4-methylnonan-5-one (IUPAC name) (544)+TX, alpha-multistriatin (alternative name) [CCN]+TX, brevicomin (alternative name) [CCN]+TX, codlelure (alternative name) [CCN]+TX, codlemone (alternative name) (167)+TX, cuelure (alternative name) (179)+TX, disparlure (277)+TX, dodec-8-en-1-yl acetate (IUPAC name) (286)+TX, dodec-9-en-1-yl acetate (IUPAC name) (287)+TX, dodeca-8+TX, 10-dien-1-yl acetate (IUPAC name) (284)+TX, dominicalure (alternative name) [CCN]+TX, ethyl 4-methyloctanoate (IUPAC name) (317)+TX, eugenol (alternative name) [CCN]+TX, frontalin (alternative name) [CCN]+TX, Gossyplure? (alternative name; 1:1 mixture of the (Z,E) and (Z,Z) isomers of hexadeca-7,11-dien-1-yl-acetate) (420)+TX, grandlure (421)+TX, grandlure I (alternative name) (421)+TX, grandlure II (alternative name) (421)+TX, grandlure III (alternative name) (421)+TX, grandlure IV (alternative name) (421)+TX, hexalure [CCN]+TX, ipsdienol (alternative name) [CCN]+TX, ipsenol (alternative name) [CCN]+TX, japonilure (alternative name) (481)+TX, lineatin (alternative name) [CCN]+TX, litlure (alternative name) [CCN]+TX, looplure (alternative name) [CCN]+TX, medlure [CCN]+TX, megatomoic acid (alternative name) [CCN]+TX, methyl eugenol (alternative name) (540)+TX, muscalure (563)+TX, octadeca-2,13-dien-1-yl acetate (IUPAC name) (588)+TX, octadeca-3,13-dien-1-yl acetate (IUPAC name) (589)+TX, orfralure (alternative name) [CCN]+TX, oryctalure (alternative name) (317)+TX, ostramone (alternative name) [CCN]+TX, siglure [CCN]+TX, sordidin (alternative name) (736)+TX, sulcatol (alternative name) [CCN]+TX, tetradec-11-en-1-yl acetate (IUPAC name) (785)+TX, trimedlure (839)+TX, trimedlure A (alternative name) (839)+TX, trimedlure B.sub.1 (alternative name) (839)+TX, trimedlure B.sub.2 (alternative name) (839)+TX, trimedlure C (alternative name) (839) and trunccall (alternative name) [CCN]+TX; [0527] an insect repellent selected from the group of substances consisting of 2-(octylthio)ethanol (IUPAC name) (591)+TX, butopyronoxyl (933)+TX, butoxy(polypropylene glycol) (936)+TX, dibutyl adipate (IUPAC name) (1046)+TX, dibutyl phthalate (1047)+TX, dibutyl succinate (IUPAC name) (1048)+TX, diethyltoluamide [CCN]+TX, dimethyl carbate [CCN]+TX, dimethyl phthalate [CCN]+TX, ethyl hexanediol (1137)+TX, hexamide [CCN]+TX, methoquin-butyl (1276)+TX, methylneodecanamide [CCN]+TX, oxamate [CCN] and picaridin [CCN]+TX; [0528] a molluscicide selected from the group of substances consisting of bis(tributyltin) oxide (IUPAC name) (913)+TX, bromoacetamide [CCN]+TX, calcium arsenate [CCN]+TX, cloethocarb (999)+TX, copper acetoarsenite [CCN]+TX, copper sulfate (172)+TX, fentin (347)+TX, ferric phosphate (IUPAC name) (352)+TX, metaldehyde (518)+TX, methiocarb (530)+TX, niclosamide (576)+TX, niclosamide-olamine (576)+TX, pentachlorophenol (623)+TX, sodium pentachlorophenoxide (623)+TX, tazimcarb (1412)+TX, thiodicarb (799)+TX, tributyltin oxide (913)+TX, trifenmorph (1454)+TX, trimethacarb (840)+TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347)+TX, pyriprole [394730-71-3]+TX; [0529] a nematicide selected from the group of substances consisting of AKD-3088 (compound code)+TX, 1,2-dibromo-3-chloropropane (IUPAC/Chemical Abstracts name) (1045)+TX, 1,2-dichloropropane (IUPAC/Chemical Abstracts name) (1062)+TX, 1,2-dichloropropane with 1,3-dichloropropene (IUPAC name) (1063)+TX, 1,3-dichloropropene (233)+TX, 3,4-dichlorotetrahydrothiophene 1,1-dioxide (IUPAC/Chemical Abstracts name) (1065)+TX, 3-(4-chlorophenyl)-5-methylrhodanine (IUPAC name) (980)+TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid (IUPAC name) (1286)+TX, 6-isopentenylaminopurine (alternative name) (210)+TX, abamectin (1)+TX, acetoprole [CCN]+TX, alanycarb (15)+TX, aldicarb (16)+TX, aldoxycarb (863)+TX, AZ 60541 (compound code)+TX, benclothiaz [CCN]+TX, benomyl (62)+TX, butylpyridaben (alternative name)+TX, cadusafos (109)+TX, carbofuran (118)+TX, carbon disulfide (945)+TX, carbosulfan (119)+TX, chloropicrin (141)+TX, chlorpyrifos (145)+TX, cloethocarb (999)+TX, cyclobutrifluram+TX, cytokinins (alternative name) (210)+TX, dazomet (216)+TX, DBCP (1045)+TX, DCIP (218)+TX, diamidafos (1044)+TX, dichlofenthion (1051)+TX, dicliphos (alternative name)+TX, dimethoate (262)+TX, doramectin (alternative name) [CCN]+TX, emamectin (291)+TX, emamectin benzoate (291)+TX, eprinomectin (alternative name) [CCN]+TX, ethoprophos (312)+TX, ethylene dibromide (316)+TX, fenamiphos (326)+TX, fenpyrad (alternative name)+TX, fensulfothion (1158)+TX, fosthiazate (408)+TX, fosthietan (1196)+TX, furfural (alternative name) [CCN]+TX, GY-81 (development code) (423)+TX, heterophos [CCN]+TX, iodomethane (IUPAC name) (542)+TX, isamidofos (1230)+TX, isazofos (1231)+TX, ivermectin (alternative name) [CCN]+TX, kinetin (alternative name) (210)+TX, mecarphon (1258)+TX, metam (519)+TX, metam-potassium (alternative name) (519)+TX, metam-sodium (519)+TX, methyl bromide (537)+TX, methyl isothiocyanate (543)+TX, milbemycin oxime (alternative name) [CCN]+TX, moxidectin (alternative name) [CCN]+TX, Myrothecium verrucaria composition (alternative name) (565)+TX, NC-184 (compound code)+TX, oxamyl (602)+TX, phorate (636)+TX, phosphamidon (639)+TX, phosphocarb [CCN]+TX, sebufos (alternative name)+TX, selamectin (alternative name) [CCN]+TX, spinosad (737)+TX, terbam (alternative name)+TX, terbufos (773)+TX, tetrachlorothiophene (IUPAC/Chemical Abstracts name) (1422)+TX, thiafenox (alternative name)+TX, thionazin (1434)+TX, triazophos (820)+TX, triazuron (alternative name)+TX, xylenols [CCN]+TX, YI-5302 (compound code) and zeatin (alternative name) (210)+TX, fluensulfone [318290-98-1]+TX, fluopyram+TX; [0530] a nitrification inhibitor selected from the group of substances consisting of potassium ethylxanthate [CCN] and nitrapyrin (580)+TX; [0531] a plant activator selected from the group of substances consisting of acibenzolar (6)+TX, acibenzolar-S-methyl (6)+TX, probenazole (658) and Reynoutria sachalinensis extract (alternative name) (720)+TX; [0532] a rodenticide selected from the group of substances consisting of 2-isovalerylindan-1,3-dione (IUPAC name) (1246)+TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748)+TX, alpha-chlorohydrin [CCN]+TX, aluminium phosphide (640)+TX, antu (880)+TX, arsenous oxide (882)+TX, barium carbonate (891)+TX, bisthiosemi (912)+TX, brodifacoum (89)+TX, bromadiolone (including alpha-bromadiolone)+TX, bromethalin (92)+TX, calcium cyanide (444)+TX, chloralose (127)+TX, chlorophacinone (140)+TX, cholecalciferol (alternative name) (850)+TX, coumachlor (1004)+TX, coumafuryl (1005)+TX, coumatetralyl (175)+TX, crimidine (1009)+TX, difenacoum (246)+TX, difethialone (249)+TX, diphacinone (273)+TX, ergocalciferol (301)+TX, flocoumafen (357)+TX, fluoroacetamide (379)+TX, flupropadine (1183)+TX, flupropadine hydrochloride (1183)+TX, gamma-HCH (430)+TX, HCH (430)+TX, hydrogen cyanide (444)+TX, iodomethane (IUPAC name) (542)+TX, lindane (430)+TX, magnesium phosphide (IUPAC name) (640)+TX, methyl bromide (537)+TX, norbormide (1318)+TX, phosacetim (1336)+TX, phosphine (IUPAC name) (640)+TX, phosphorus [CCN]+TX, pindone (1341)+TX, potassium arsenite [CCN]+TX, pyrinuron (1371)+TX, scilliroside (1390)+TX, sodium arsenite [CCN]+TX, sodium cyanide (444)+TX, sodium fluoroacetate (735)+TX, strychnine (745)+TX, thallium sulfate [CCN]+TX, warfarin (851) and zinc phosphide (640)+TX; a synergist selected from the group of substances consisting of 2-(2-butoxyethoxy)ethyl piperonylate (IUPAC name) (934)+TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone (IUPAC name) (903)+TX, farnesol with nerolidol (alternative name) (324)+TX, MB-599 (development code) (498)+TX, MGK 264 (development code) (296)+TX, piperonyl butoxide (649)+TX, piprotal (1343)+TX, propyl isomer (1358)+TX, S421 (development code) (724)+TX, sesamex (1393)+TX, sesasmolin (1394) and sulfoxide (1406)+TX; [0533] an animal repellent selected from the group of substances consisting of anthraquinone (32)+TX, chloralose (127)+TX, copper naphthenate [CCN]+TX, copper oxychloride (171)+TX, diazinon (227)+TX, dicyclopentadiene (chemical name) (1069)+TX, guazatine (422)+TX, guazatine acetates (422)+TX, methiocarb (530)+TX, pyridin-4-amine (IUPAC name) (23)+TX, thiram (804)+TX, trimethacarb (840)+TX, zinc naphthenate [CCN] and ziram (856)+TX; a virucide selected from the group of substances consisting of imanin (alternative name) [CCN] and ribavirin (alternative name) [CCN]+TX; [0534] a wound protectant selected from the group of substances consisting of mercuric oxide (512)+TX, octhilinone (590) and thiophanate-methyl (802)+TX; [0535] a biologically active substance selected from 1,1-bis(4-chloro-phenyl)-2-ethoxyethanol+TX, 2,4-dichlorophenyl benzenesulfonate+TX, 2-fluoro-N-methyl-N-1-naphthylacetamide+TX, 4-chlorophenyl phenyl sulfone+TX, acetoprole+TX, aldoxycarb+TX, amidithion+TX, amidothioate+TX, amiton+TX, amiton hydrogen oxalate+TX, amitraz+TX, aramite+TX, arsenous oxide+TX, azobenzene+TX, azothoate+TX, benomyl+TX, benoxa-fos+TX, benzyl benzoate+TX, bixafen+TX, brofenvalerate+TX, bromo-cyclen+TX, bromophos+TX, bromopropylate+TX, buprofezin+TX, butocarboxim+TX, butoxycarboxim+TX, butylpyridaben+TX, calcium polysulfide+TX, camphechlor+TX, carbanolate+TX, carbophenothion+TX, cymiazole+TX, chino-methionat+TX, chlorbenside+TX, chlordimeform+TX, chlordimeform hydrochloride+TX, chlorfenethol+TX, chlorfenson+TX, chlorfensulfide+TX, chlorobenzilate+TX, chloromebuform+TX, chloromethiuron+TX, chloropropylate+TX, chlorthiophos+TX, cinerin I+TX, cinerin II+TX, cinerins+TX, closantel+TX, coumaphos+TX, crotamiton+TX, crotoxyphos+TX, cufraneb+TX, cyanthoate+TX, DCPM+TX, DDT+TX, demephion+TX, demephion-O+TX, demephion-S+TX, demeton-methyl+TX, demeton-O+TX, demeton-O-methyl+TX, demeton-S+TX, demeton-S-methyl+TX, demeton-S-methylsulfon+TX, dichlofluanid+TX, dichlorvos+TX, dicliphos+TX, dienochlor+TX, dimefox+TX, dinex+TX, dinex-diclexine+TX, dinocap-4+TX, dinocap-6+TX, dinocton+TX, dino-penton+TX, dinosulfon+TX, dinoterbon+TX, dioxathion+TX, diphenyl sulfone+TX, disulfiram+TX, DNOC+TX, dofenapyn+TX, doramectin+TX, endothion+TX, eprinomectin+TX, ethoate-methyl+TX, etrimfos+TX, fenazaflor+TX, fenbutatin oxide+TX, fenothiocarb+TX, fenpyrad+TX, fen-pyroximate+TX, fenpyrazamine+TX, fenson+TX, fentrifanil+TX, flubenzimine+TX, flucycloxuron+TX, fluenetil+TX, fluorbenside+TX, FMC 1137+TX, formetanate+TX, formetanate hydrochloride+TX, formparanate+TX, gamma-HCH+TX, glyodin+TX, halfenprox+TX, hexadecyl cyclopropanecarboxylate+TX, isocarbophos+TX, jasmolin I+TX, jasmolin II+TX, jodfenphos+TX, lindane+TX, malonoben+TX, mecarbam+TX, mephosfolan+TX, mesulfen+TX, methacrifos+TX, methyl bromide+TX, metolcarb+TX, mexacarbate+TX, milbemycin oxime+TX, mipafox+TX, monocrotophos+TX, morphothion+TX, moxidectin+TX, naled+TX, 4-chloro-2-(2-chloro-2-methyl-propyl)-5-[(6-iodo-3-pyridyl)methoxy]pyridazin-3-one+TX, nifluridide+TX, nikkomycins+TX, nitrilacarb+TX, nitrilacarb 1:1 zinc chloride complex+TX, omethoate+TX, oxydeprofos+TX, oxydisulfoton+TX, pp-DDT+TX, parathion+TX, permethrin+TX, phenkapton+TX, phosalone+TX, phosfolan+TX, phosphamidon+TX, polychloroterpenes+TX, polynactins+TX, proclonol+TX, promacyl+TX, propoxur+TX, prothidathion+TX, prothoate+TX, pyrethrin I+TX, pyrethrin II+TX, pyrethrins+TX, pyridaphenthion+TX, pyrimitate+TX, quinalphos+TX, quintiofos+TX, R-1492+TX, phosglycin+TX, rotenone+TX, schradan+TX, sebufos+TX, selamectin+TX, sophamide+TX, SSI-121+TX, sulfiram+TX, sulfluramid+TX, sulfotep+TX, sulfur+TX, diflovidazin+TX, tau-fluvalinate+TX, TEPP+TX, terbam+TX, tetradifon+TX, tetrasul+TX, thiafenox+TX, thiocarboxime+TX, thiofanox+TX, thiometon+TX, thioquinox+TX, thuringiensin+TX, triamiphos+TX, triarathene+TX, triazophos+TX, triazuron+TX, trifenofos+TX, trinactin+TX, vamidothion+TX, vaniliprole+TX, bethoxazin+TX, copper dioctanoate+TX, copper sulfate+TX, cybutryne+TX, dichlone+TX, dichlorophen+TX, endothal+TX, fentin+TX, hydrated lime+TX, nabam+TX, quinoclamine+TX, quinonamid+TX, simazine+TX, triphenyltin acetate+TX, triphenyltin hydroxide+TX, crufomate+TX, piperazine+TX, thiophanate+TX, chloralose+TX, fenthion+TX, pyridin-4-amine+TX, strychnine+TX, 1-hydroxy-1H-pyridine-2-thione+TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide+TX, 8-hydroxyquinoline sulfate+TX, bronopol+TX, copper hydroxide+TX, cresol+TX, dipyrithione+TX, dodicin+TX, fenaminosulf+TX, formaldehyde+TX, hydrargaphen+TX, kasugamycin+TX, kasugamycin hydrochloride hydrate+TX, nickel bis(dimethyldithiocarbamate)+TX, nitrapyrin+TX, octhilinone+TX, oxolinic acid+TX, oxytetracycline+TX, potassium hydroxyquinoline sulfate+TX, probenazole+TX, streptomycin+TX, streptomycin sesquisulfate+TX, tecloftalam+TX, thiomersal+TX, Adoxophyes orana GV+TX, Agrobacterium radiobacter+TX, Amblyseius spp.+TX, Anagrapha falcifera NPV+TX, Anagrus atomus+TX, Aphelinus abdominalis+TX, Aphidius colemani+TX, Aphidoletes aphidimyza+TX, Autographa californica NPV+TX, Bacillus sphaericus Neide+TX, Beauveria brongniartii+TX, Chrysoperla carnea+TX, Cryptolaemus montrouzieri+TX, Cydia pomonella GV+TX, Dacnusa sibirica+TX, Diglyphus isaea+TX, Encarsia formosa+TX, Eretmocerus eremicus+TX, Heterorhabditis bacteriophora and H. megidis+TX, Hippodamia convergens+TX, Leptomastix dactylopii+TX, Macrolophus caliginosus+TX, Mamestra brassicae NPV+TX, Metaphycus helvolus+TX, Metarhizium anisopliae var. acridum+TX, Metarhizium anisopliae var. anisopliae+TX, Neodiprion sertifer NPV and N. lecontei NPV+TX, Orius spp.+TX, Paecilomyces fumosoroseus+TX, Phytoseiulus persimilis+TX, Steinernema bibionis+TX, Steinernema carpocapsae+TX, Steinernema feltiae+TX, Steinernema glaseri+TX, Steinernema riobrave+TX, Steinernema riobravis+TX, Steinernema scapterisci+TX, Steinernema spp.+TX, Trichogramma spp.+TX, Typhlodromus occidentalis+TX, Verticillium lecanii+TX, apholate+TX, bisazir+TX, busulfan+TX, dimatif+TX, hemel+TX, hempa+TX, metepa+TX, methiotepa+TX, methyl apholate+TX, morzid+TX, penfluron+TX, tepa+TX, thiohempa+TX, thiotepa+TX, tretamine+TX, uredepa+TX, (E)-dec-5-en-1-yl acetate with (E)-dec-5-en-1-ol+TX, (E)-tridec-4-en-1-yl acetate+TX, (E)-6-methylhept-2-en-4-ol+TX, (E,Z)-tetradeca-4,10-dien-1-yl acetate+TX, (Z)-dodec-7-en-1-yl acetate+TX, (Z)-hexadec-11-enal+TX, (Z)-hexadec-11-en-1-yl acetate+TX, (Z)-hexadec-13-en-11-yn-1-yl acetate+TX, (Z)-icos-13-en-10-one+TX, (Z)-tetradec-7-en-1-al+TX, (Z)-tetradec-9-en-1-ol+TX, (Z)-tetradec-9-en-1-yl acetate+TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate+TX, (9Z,11E)-tetradeca-9,11-dien-1-yl acetate+TX, (9Z,12E)-tetradeca-9,12-dien-1-yl acetate+TX, 14-methyloctadec-1-ene+TX, 4-methylnonan-5-ol with 4-methylnonan-5-one+TX, alpha-multistriatin+TX, brevicomin+TX, codlelure+TX, codlemone+TX, cuelure+TX, disparlure+TX, dodec-8-en-1-yl acetate+TX, dodec-9-en-1-yl acetate+TX, dodeca-8+TX, 10-dien-1-yl acetate+TX, dominicalure+TX, ethyl 4-methyloctanoate+TX, eugenol+TX, frontalin+TX, grandlure+TX, grandlure I+TX, grandlure II+TX, grandlure III+TX, grandlure IV+TX, hexalure+TX, ipsdienol+TX, ipsenol+TX, japonilure+TX, lineatin+TX, litlure+TX, looplure+TX, medlure+TX, megatomoic acid+TX, methyl eugenol+TX, muscalure+TX, octadeca-2,13-dien-1-yl acetate+TX, octadeca-3,13-dien-1-yl acetate+TX, orfralure+TX, oryctalure+TX, ostramone+TX, siglure+TX, sordidin+TX, sulcatol+TX, tetradec-11-en-1-yl acetate+TX, trimedlure+TX, trimedlure A+TX, trimedlure B.sub.1+TX, trimedlure B.sub.2+TX, trimedlure C+TX, trunc-call+TX, 2-(octylthio)-ethanol+TX, butopyronoxyl+TX, butoxy(polypropylene glycol)+TX, dibutyl adipate+TX, dibutyl phthalate+TX, dibutyl succinate+TX, diethyltoluamide+TX, dimethyl carbate+TX, dimethyl phthalate+TX, ethyl hexanediol+TX, hexamide+TX, methoquin-butyl+TX, methylneodecanamide+TX, oxamate+TX, picaridin+TX, 1-dichloro-1-nitroethane+TX, 1,1-dichloro-2,2-bis(4-ethylphenyl)-ethane+TX, 1,2-dichloropropane with 1,3-dichloropropene+TX, 1-bromo-2-chloroethane+TX, 2,2,2-trichloro-1-(3,4-dichloro-phenyl)ethyl acetate+TX, 2,2-dichlorovinyl 2-ethylsulfinylethyl methyl phosphate+TX, 2-(1,3-dithiolan-2-yl)phenyl dimethylcarbamate+TX, 2-(2-butoxyethoxy)ethyl thiocyanate+TX, 2-(4,5-dimethyl-1,3-dioxolan-2-yl)phenyl methylcarbamate+TX, 2-(4-chloro-3,5-xylyloxy)ethanol+TX, 2-chlorovinyl diethyl phosphate+TX, 2-imidazolidone+TX, 2-isovalerylindan-1,3-dione+TX, 2-methyl(prop-2-ynyl)aminophenyl methylcarbamate+TX, 2-thiocyanatoethyl laurate+TX, 3-bromo-1-chloroprop-1-ene+TX, 3-methyl-1-phenylpyrazol-5-yl dimethyl-carbamate+TX, 4-methyl(prop-2-ynyl)amino-3,5-xylyl methylcarbamate+TX, 5,5-dimethyl-3-oxocyclohex-1-enyl dimethylcarbamate+TX, acethion+TX, acrylonitrile+TX, aldrin+TX, allosamidin+TX, allyxycarb+TX, alpha-ecdysone+TX, aluminium phosphide+TX, aminocarb+TX, anabasine+TX, athidathion+TX, azamethiphos+TX, Bacillus thuringiensis delta endotoxins+TX, barium hexafluorosilicate+TX, barium polysulfide+TX, barthrin+TX, Bayer 22/190+TX, Bayer 22408+TX, beta-cyfluthrin+TX, beta-cypermethrin+TX, bioethanomethrin+TX, biopermethrin+TX, bis(2-chloroethyl) ether+TX, borax+TX, bromfenvinfos+TX, bromo-DDT+TX, bufencarb+TX, butacarb+TX, butathiofos+TX, butonate+TX, calcium arsenate+TX, calcium cyanide+TX, carbon disulfide+TX, carbon tetrachloride+TX, cartap hydrochloride+TX, cevadine+TX, chlorbicyclen+TX, chlordane+TX, chlordecone+TX, chloroform+TX, chloropicrin+TX, chlorphoxim+TX, chlorprazophos+TX, cis-resmethrin+TX, cismethrin+TX, clocythrin+TX, copper acetoarsenite+TX, copper arsenate+TX, copper oleate+TX, coumithoate+TX, cryolite+TX, CS 708+TX, cyanofenphos+TX, cyanophos+TX, cyclethrin+TX, cythioate+TX, d-tetramethrin+TX, DAEP+TX, dazomet+TX, decarbofuran+TX, diamidafos+TX, dicapthon+TX, dichlofenthion+TX, dicresyl+TX, dicyclanil+TX, dieldrin+TX, diethyl 5-methylpyrazol-3-yl phosphate+TX, dilor+TX, dimefluthrin+TX, dimetan+TX, dimethrin+TX, dimethylvinphos+TX, dimetilan+TX, dinoprop+TX, dinosam+TX, dinoseb+TX, diofenolan+TX, dioxabenzofos+TX, dithicrofos+TX, DSP+TX, ecdysterone+TX, EI 1642+TX, EMPC+TX, EPBP+TX, etaphos+TX, ethiofencarb+TX, ethyl formate+TX, ethylene dibromide+TX, ethylene dichloride+TX, ethylene oxide+TX, EXD+TX, fenchlorphos+TX, fenethacarb+TX, fenitrothion+TX, fenoxacrim+TX, fenpirithrin+TX, fensulfothion+TX, fenthion-ethyl+TX, flucofuron+TX, fosmethilan+TX, fospirate+TX, fosthietan+TX, furathiocarb+TX, furethrin+TX, guazatine+TX, guazatine acetates+TX, sodium tetrathiocarbonate+TX, halfenprox+TX, HCH+TX, HEOD+TX, heptachlor+TX, heterophos+TX, HHDN+TX, hydrogen cyanide+TX, hyquincarb+TX, IPSP+TX, isazofos+TX, isobenzan+TX, isodrin+TX, isofenphos+TX, isolane+TX, isoprothiolane+TX, isoxathion+TX, juvenile hormone I+TX, juvenile hormone II+TX, juvenile hormone III+TX, kelevan+TX, kinoprene+TX, lead arsenate+TX, leptophos+TX, lirimfos+TX, lythidathion+TX, m-cumenyl methylcarbamate+TX, magnesium phosphide+TX, mazidox+TX, mecarphon+TX, menazon+TX, mercurous chloride+TX, mesulfenfos+TX, metam+TX, metam-potassium+TX, metam-sodium+TX, methanesulfonyl fluoride+TX, methocrotophos+TX, methoprene+TX, methothrin+TX, methoxychlor+TX, methyl isothiocyanate+TX, methylchloroform+TX, methylene chloride+TX, metoxadiazone+TX, mirex+TX, naftalofos+TX, naphthalene+TX, NC-170+TX, nicotine+TX, nicotine sulfate+TX, nithiazine+TX, nornicotine+TX, O-5-dichloro-4-iodophenyl O-ethyl ethylphosphonothioate+TX, O,O-diethyl O-4-methyl-2-oxo-2H-chromen-7-yl phosphorothioate+TX, O,O-diethyl O-6-methyl-2-propylpyrimidin-4-yl phosphorothioate+TX, O,O,O,O-tetrapropyl dithiopyrophosphate+TX, oleic acid+TX, para-dichlorobenzene+TX, parathion-methyl+TX, pentachlorophenol+TX, pentachlorophenyl laurate+TX, PH 60-38+TX, phenkapton+TX, phosnichlor+TX, phosphine+TX, phoxim-methyl+TX, pirimetaphos+TX, polychlorodicyclopentadiene isomers+TX, potassium arsenite+TX, potassium thiocyanate+TX, precocene I+TX, precocene II+TX, precocene III+TX, primidophos+TX, profluthrin+TX, promecarb+TX, prothiofos+TX, pyrazophos+TX, pyresmethrin+TX, quassia+TX, quinalphos-methyl+TX, quinothion+TX, rafoxanide+TX, resmethrin+TX, rotenone+TX, kadethrin+TX, ryania+TX, ryanodine+TX, sabadilla+TX, schradan+TX, sebufos+TX, SI-0009+TX, thiapronil+TX, sodium arsenite+TX, sodium cyanide+TX, sodium fluoride+TX, sodium hexafluorosilicate+TX, sodium pentachlorophenoxide+TX, sodium selenate+TX, sodium thiocyanate+TX, sulcofuron+TX, sulcofuron-sodium+TX, sulfuryl fluoride+TX, sulprofos+TX, tar oils+TX, tazimcarb+TX, TDE+TX, tebupirimfos+TX, temephos+TX, terallethrin+TX, tetrachloroethane+TX, thicrofos+TX, thiocyclam+TX, thiocyclam hydrogen oxalate+TX, thionazin+TX, thiosultap+TX, thiosultap-sodium+TX, tralomethrin+TX, transpermethrin+TX, triazamate+TX, trichlormetaphos-3+TX, trichloronat+TX, trimethacarb+TX, tolprocarb+TX, triclopyricarb+TX, triprene+TX, veratridine+TX, veratrine+TX, XMC+TX, zetamethrin+TX, zinc phosphide+TX, zolaprofos+TX, meperfluthrin+TX, tetramethylfluthrin+TX, bis(tributyltin) oxide+TX, bromoacetamide+TX, ferric phosphate+TX, niclosamide-olamine+TX, tributyltin oxide+TX, pyrimorph+TX, trifenmorph+TX, 1,2-dibromo-3-chloropropane+TX, 1,3-dichloropropene+TX, 3,4-dichlorotetrahydrothio-phene 1,1-dioxide+TX, 3-(4-chlorophenyl)-5-methylrhodanine+TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid+TX, 6-isopentenylaminopurine+TX, anisiflupurin+TX, benclothiaz+TX, cytokinins+TX, DCIP+TX, furfural+TX, isamidofos+TX, kinetin+TX, Myrothecium verrucaria composition+TX, tetrachlorothiophene+TX, xylenols+TX, zeatin+TX, potassium ethylxanthate+TX, acibenzolar+TX, acibenzolar-S-methyl+TX, Reynoutria sachalinensis extract+TX, alpha-chlorohydrin+TX, antu+TX, barium carbonate+TX, bisthiosemi+TX, brodifacoum+TX, bromadiolone+TX, bromethalin+TX, chlorophacinone+TX, cholecalciferol+TX, coumachlor+TX, coumafuryl+TX, coumatetralyl+TX, crimidine+TX, difenacoum+TX, difethialone+TX, diphacinone+TX, ergocalciferol+TX, flocoumafen+TX, fluoroacetamide+TX, flupropadine+TX, flupropadine hydrochloride+TX, norbormide+TX, phosacetim+TX, phosphorus+TX, pindone+TX, pyrinuron+TX, scilliroside+TX, -sodium fluoroacetate+TX, thallium sulfate+TX, warfarin+TX, -2-(2-butoxyethoxy)ethyl piperonylate+TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone+TX, farnesol with nerolidol+TX, verbutin+TX, MGK 264+TX, piperonyl butoxide+TX, piprotal+TX, propyl isomer+TX, S421+TX, sesamex+TX, sesasmolin+TX, sulfoxide+TX, anthraquinone+TX, copper naphthenate+TX, copper oxychloride+TX, dicyclopentadiene+TX, thiram+TX, zinc naphthenate+TX, ziram+TX, imanin+TX, ribavirin+TX, chloroinconazide+TX, mercuric oxide+TX, thiophanate-methyl+TX, azaconazole+TX, bitertanol+TX, bromuconazole+TX, cyproconazole+TX, difenoconazole+TX, diniconazole-+TX, epoxiconazole+TX, fenbuconazole+TX, fluquinconazole+TX, flusilazole+TX, flutriafol+TX, furametpyr+TX, hexaconazole+TX, imazalil-+TX, imiben-conazole+TX, ipconazole+TX, metconazole+TX, myclobutanil+TX, paclobutrazole+TX, pefurazoate+TX, penconazole+TX, prothioconazole+TX, pyrifenox+TX, prochloraz+TX, propiconazole+TX, pyrisoxazole+TX, -simeconazole+TX, tebucon-azole+TX, tetraconazole+TX, triadimefon+TX, triadimenol+TX, triflumizole+TX, triticonazole+TX, ancymidol+TX, fenarimol+TX, nuarimol+TX, bupirimate+TX, dimethirimol+TX, ethirimol+TX, dodemorph+TX, fenpropidin+TX, fenpropimorph+TX, spiroxamine+TX, tridemorph+TX, cyprodinil+TX, mepanipyrim+TX, pyrimethanil+TX, fenpiclonil+TX, fludioxonil+TX, benalaxyl+TX, furalaxyl+TX, -metalaxyl-+TX, Rmetalaxyl+TX, ofurace+TX, oxadixyl+TX, carbendazim+TX, debacarb+TX, fuberidazole-+TX, thiabendazole+TX, chlozolinate+TX, dichlozoline+TX, myclozoline-+TX, procymidone+TX, vinclozoline+TX, boscalid+TX, carboxin+TX, fenfuram+TX, flutolanil+TX, mepronil+TX, oxycarboxin+TX, penthiopyrad+TX, thifluzamide+TX, dodine+TX, iminoctadine+TX, azoxystrobin+TX, dimoxystrobin+TX, enestroburin+TX, fenaminstrobin+TX, flufenoxystrobin+TX, fluoxastrobin+TX, kresoximmethyl+TX, metominostrobin+TX, trifloxystrobin+TX, orysastrobin+TX, picoxystrobin+TX, pyraclostrobin+TX, pyrametostrobin+TX, pyraoxystrobin+TX, ferbam+TX, mancozeb+TX, maneb+TX, metiram+TX, propineb+TX, zineb+TX, captafol+TX, captan+TX, fluoroimide+TX, folpet+TX, tolylfluanid+TX, bordeaux mixture+TX, copper oxide+TX, mancopper+TX, oxine-copper+TX, nitrothal-isopropyl+TX, edifenphos+TX, iprobenphos+TX, phosdiphen+TX, tolclofos-methyl+TX, anilazine+TX, benthiavalicarb+TX, blasticidin-S+TX, chloroneb-+TX, chloro-tha-lonil+TX, cyflufenamid+TX, cymoxanil+TX, cyclobutrifluram+TX, diclocymet+TX, diclomezine-+TX, dicloran+TX, diethofencarb+TX, dimethomorph-+TX, flumorph+TX, dithianon+TX, ethaboxam+TX, etridiazole+TX, famoxadone+TX, fenamidone+TX, fenoxanil+TX, ferimzone+TX, fluazinam+TX, flumetylsulforim+TX, fluopicolide+TX, fluoxytioconazole+TX, flusulfamide+TX, fluxapyroxad+TX, -fenhexamid+TX, fosetyl-aluminium-+TX, hymexazol+TX, iprovalicarb+TX, cyazofamid+TX, methasulfocarb+TX, metrafenone+TX, pencycuron+TX, phthalide+TX, polyoxins+TX, propamocarb+TX, pyribencarb+TX, proquinazid+TX, pyroquilon+TX, pyriofenone+TX, quinoxyfen+TX, quintozene+TX, tiadinil+TX, triazoxide+TX, tricyclazole+TX, triforine+TX, validamycin+TX, valifenalate+TX, zoxamide+TX, mandipropamid+TX, flubeneteram+TX, isopyrazam+TX, sedaxane+TX, benzovindiflupyr+TX, pydiflumetofen+TX, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3,4,5-trifluoro-biphenyl-2-yl)-amide+TX, isoflucypram+TX, isotianil+TX, dipymetitrone+TX, 6-ethyl-5,7-dioxo-pyrrolo[4,5][1,4]dithiino[1,2-c]isothiazole-3-carbonitrile+TX, 2-(difluoromethyl)-N-[3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide+TX, 4-(2,6-difluorophenyl)-6-methyl-5-phenyl-pyridazine-3-carbonitrile+TX, (R)-3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide+TX, 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro-phenyl)-2,5-dimethyl-pyrazol-3-amine+TX, 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-11H-pyrazol-5-amine+TX, fluindapyr+TX, coumethoxystrobin (iiaxiangjunzhi)+TX, Ivbenmixianan+TX, dichlobentiazox+TX, mandestrobin+TX, 3-(4,4-difluoro-3,4-dihydro-3,3-dimethylisoquinolin-1-yl)quinolone+TX, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3-quinolyl)oxy]phenyl]propan-2-ol+TX, oxathiapiprolin+TX, tert-butyl N-[6-[[[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate+TX, pyraziflumid+TX, inpyrfluxam+TX, trolprocarb+TX, mefentrifluconazole+TX, ipfentrifluconazole+TX, 2-(difluoromethyl)-N-[(3R)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide+TX, N-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine+TX, N-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl-N-methyl-formamidine+TX, [2-[3-[2-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]thiazol-4-yl]-4,5-dihydroisoxazol-5-yl]-3-chloro-phenyl]methanesulfonate+TX, but-3-ynyl N-[6-[[(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate+TX, methyl N-[[5-[4-(2,4-dimethylphenyl)triazol-2-yl]-2-methyl-phenyl]methyl]carbamate+TX, 3-chloro-6-methyl-5-phenyl-4-(2,4,6-trifluorophenyl)pyridazine+TX, pyridachlometyl+TX, 3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide+TX, 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one+TX, 1-methyl-4-[3-methyl-2-[[2-methyl-4-(3,4,5-trimethylpyrazol-1-yl)phenoxy]methyl]phenyl]tetrazol-5-one+TX, aminopyrifen+TX, ametoctradin+TX, amisulbrom+TX, penflufen+TX, (Z,2E)-5-[1-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamide+TX, florylpicoxamid+TX, fenpicoxamid+TX, metarylpicoxamid+TX, tebufloquin+TX, ipflufenoquin+TX, quinofumelin+TX, isofetamid+TX, ethyl 1-[[4-[[2-(trifluoromethyl)-1,3-dioxolan-2-yl]methoxy]phenyl]methyl]pyrazole-3-carboxylate (may be prepared from the methods described in WO 2020/056090)+TX, ethyl 1-[[4-[(Z)-2-ethoxy-3,3,3-trifluoro-prop-1-enoxy]phenyl]methyl]pyrazole-3-carboxylate (may be prepared from the methods described in WO 2020/056090)+TX, methyl N-[[4-[1-(4-cyclopropyl-2,6-difluoro-phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamate (may be prepared from the methods described in WO 2020/097012)+TX, methyl N-[[4-[1-(2,6-difluoro-4-isopropyl-phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamate (may be prepared from the methods described in WO 2020/097012)+TX, 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(2,4-dimethylphenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (may be prepared from the methods described in WO 2020/109391)+TX, 6-chloro-N-[2-(2-chloro-4-methyl-phenyl)-2,2-difluoro-ethyl]-3-(3-cyclopropyl-2-fluoro-phenoxy)-5-methyl-pyridazine-4-carboxamide (may be prepared from the methods described in WO 2020/109391)+TX, 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(3,4-dimethylphenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (may be prepared from the methods described in WO 2020/109391)+TX, N-[2-[2,4-dichloro-phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide+TX, N-[2-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide+TX, benzothiostrobin+TX, phenamacril+TX, 5-amino-1,3,4-thiadiazole-2-thiol zinc salt (2:1)+TX, fluopyram+TX, flufenoxadiazam+TX, flutianil+TX, fluopimomide+TX, pyrapropoyne+TX, picarbutrazox+TX, 2-(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indan-4-yl)pyridine-3-carboxamide+TX, 2-(difluoromethyl)-N-((3R)-1,1,3-trimethylindan-4-yl)pyridine-3-carboxamide+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile+TX, metyltetraprole+TX, 2-(difluoromethyl)-N-((3R)-1,1,3-trimethylindan-4-yl)pyridine-3-carboxamide+TX, ?-(1,1-dimethylethyl)-?-[4-(trifluoromethoxy) [1,1-biphenyl]-4-yl]-5-pyrimidinemethanol+TX, fluoxapiprolin+TX, enoxastrobin+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-sulfanyl-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4H-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile+TX, trinexapac+TX, coumoxystrobin+TX, zhongshengmycin+TX, thiodiazole copper+TX, zinc thiazole+TX, amectotractin+TX, iprodione+TX, seboctylamine+TX; N-[5-bromo-2-methyl-6-[(1S)-1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N-[5-bromo-2-methyl-6-[(1R)-1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N-[5-chloro-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl-N-methyl-formamidine+TX (these compounds may be prepared from the methods described in WO2015/155075); N-[5-bromo-2-methyl-6-(2-propoxypropoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX (this compound may be prepared from the methods described in IPCOM000249876D); N-isopropyl-N-[5-methoxy-2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-phenyl-ethyl)phenyl]-N-methyl-formamidine+TX, N-[4-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxy-ethyl)-5-methoxy-2-methyl-phenyl]-N-isopropyl-N-methyl-formamidine+TX (these compounds may be prepared from the methods described in WO2018/228896); N-ethyl-N-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]-N-methyl-formamidine+TX, N-ethyl-N-[5-methoxy-2-methyl-4-[(2-trifuoromethyl)tetrahydrofuran-2-yl]phenyl]-N-methyl-formamidine+TX (these compounds may be prepared from the methods described in WO2019/110427); N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide+TX, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide+TX, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide+TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide+TX, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide+TX, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide+TX (these compounds may be prepared from the methods described in WO2017/153380); 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline+TX, 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,6-trifluoro-3,3-dimethyl-isoquinoline+TX, 4,4-difluoro-3,3-dimethyl-1-(6-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline+TX, 4,4-difluoro-3,3-dimethyl-1-(7-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline+TX, 1-(6-chloro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline+TX (these compounds may be prepared from the methods described in WO2017/025510); 1-(4,5-dimethylbenzimidazol-1-yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline+TX, 1-(4,5-dimethylbenzimidazol-1-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline+TX, 6-chloro-4,4-difluoro-3,3-dimethyl-1-(4-methylbenzimidazol-1-yl)isoquinoline+TX, 4,4-difluoro-1-(5-fluoro-4-methyl-benzimidazol-1-yl)-3,3-dimethyl-isoquinoline+TX, 3-(4,4-difluoro-3,3-dimethyl-1-isoquinolyl)-7,8-dihydro-6H-cyclopenta[e]benzimidazole+TX (these compounds may be prepared from the methods described in WO2016/156085); N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide+TX, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide+TX, N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide+TX, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, 3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide+TX, 4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one+TX, 5,5-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one+TX, ethyl 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate+TX, N,N-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1,2,4-triazol-3-amine+TX. The compounds in this paragraph may be prepared from the methods described in WO 2017/055473, WO 2017/055469, WO 2017/093348 and WO 2017/118689; 2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol+TX (this compound may be prepared from the methods described in WO 2017/029179); 2-[6-(4-bromophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol+TX (this compound may be prepared from the methods described in WO 2017/029179); 3-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxy-propyl]imidazole-4-carbonitrile+TX (this compound may be prepared from the methods described in WO 2016/156290); 3-[2-(1-chlorocyclopropyl)-3-(3-chloro-2-fluoro-phenyl)-2-hydroxy-propyl]imidazole-4-carbonitrile+TX (this compound may be prepared from the methods described in WO 2016/156290); (4-phenoxyphenyl)methyl 2-amino-6-methyl-pyridine-3-carboxylate+TX (this compound may be prepared from the methods described in WO 2014/006945); 2,6-Dimethyl-1H,5H-[1,4]dithiino[2,3-c: 5,6-c]dipyrrole-1,3,5,7(2H,6H)-tetrone+TX (this compound may be prepared from the methods described in WO 2011/138281); N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzenecarbothioamide+TX; N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX; (Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamide+TX (this compound may be prepared from the methods described in WO 2018/153707); N-(2-chloro-5-methyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine+TX; N-[2-chloro-4-(2-fluorophenoxy)-5-methyl-phenyl]-N-ethyl-N-methyl-formamidine+TX (this compound may be prepared from the methods described in WO 2016/202742); 2-(difluoromethyl)-N-[(3S)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide+TX (this compound may be prepared from the methods described in WO 2014/095675); (5-methyl-2-pyridyl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone+TX, (3-methylisoxazol-5-yl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone+TX (these compounds may be prepared from the methods described in WO 2017/220485); 2-oxo-N-propyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide+TX (this compound may be prepared from the methods described in WO 2018/065414); ethyl 1-[[5-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]pyrazole-4-carboxylate+TX (this compound may be prepared from the methods described in WO 2018/158365); 2,2-difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide+TX, N-[(E)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX, N[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX, N[N-methoxy-C-methyl-carbonimidoyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX (these compounds may be prepared from the methods described in WO 2018/202428); [0536] microbials including: Acinetobacter lwoffii+TX, Acremonium alternatum+TX+TX, Acremonium cephalosporium+TX+TX, Acremonium diospyri+TX, Acremonium obclavatum+TX, Adoxophyes orana granulovirus (AdoxGV) (Capex?)+TX, Agrobacterium radiobacter strain K84 (Galltrol-A?)+TX, Alternaria alternate+TX, Alternaria cassia+TX, Alternaria destruens (Smolder?)+TX, Ampelomyces quisqualis (AQ10?)+TX, Aspergillus flavus AF36 (AF36?)+TX, Aspergillus flavus NRRL 21882 (Aflaguard?)+TX, Aspergillus spp.+TX, Aureobasidium pullulans+TX, Azospirillum+TX, (MicroAZ?+TX, TAZO B?)+TX, Azotobacter+TX, Azotobacter chroocuccum (Azotomeal?)+TX, Azotobacter cysts (Bionatural Blooming Blossoms?)+TX, Bacillus amyloliquefaciens+TX, Bacillus cereus+TX, Bacillus chitinosporus strain CM-1+TX, Bacillus chitinosporus strain AQ746+TX, Bacillus licheniformis strain HB-2 (Biostart? Rhizoboost?)+TX, Bacillus licheniformis strain 3086 (EcoGuard?+TX, Green Releaf?)+TX, Bacillus circulans+TX, Bacillus firmus (BioSafe?+TX, BioNem-WP?+TX, VOTiVO?)+TX, Bacillus firmus strain 1-1582+TX, Bacillus macerans+TX, Bacillus marismortui+TX, Bacillus megaterium+TX, Bacillus mycoides strain AQ726+TX, Bacillus papillae (Milky Spore Powder?)+TX, Bacillus pumilus spp.+TX, Bacillus pumilus strain GB34 (Yield Shield?)+TX, Bacillus pumilus strain AQ717+TX, Bacillus pumilus strain QST 2808 (Sonata?+TX, Ballad Plus?)+TX, Bacillus spahericus (VectoLex?)+TX, Bacillus spp.+TX, Bacillus spp. strain AQ175+TX, Bacillus spp. strain AQ177+TX, Bacillus spp. strain AQ178+TX, Bacillus subtilis strain QST 713 (CEASE?+TX, Serenade?+TX, Rhapsody?)+TX, Bacillus subtilis strain QST 714 (JAZZ?)+TX, Bacillus subtilis strain AQ153+TX, Bacillus subtilis strain AQ743+TX, Bacillus subtilis strain QST3002+TX, Bacillus subtilis strain QST3004+TX, Bacillus subtilis var. amyloliquefaciens strain FZB24 (Taegro?+TX, Rhizopro?)+TX, Bacillus thuringiensis Cry 2Ae+TX, Bacillus thuringiensis Cry1Ab+TX, Bacillus thuringiensis aizawai GC 91 (Agree?)+TX, Bacillus thuringiensis israelensis (BMP123?+TX, Aquabac?+TX, VectoBac?)+TX, Bacillus thuringiensis kurstaki (Javelin?+TX, Deliver?+TX, CryMax?+TX, Bonide?+TX, Scutella WP?+TX, Turilav WP?+TX, Astuto?+TX, Dipel WP?+TX, Biobit?+TX, Foray?)+TX, Bacillus thuringiensis kurstaki BMP 123 (Baritone?)+TX, Bacillus thuringiensis kurstaki HD-1 (Bioprotec-CAF/3P?)+TX, Bacillus thuringiensis strain BD #32+TX, Bacillus thuringiensis strain AQ52+TX, Bacillus thuringiensis var. aizawai (XenTari?+TX, DiPel?)+TX, bacteria spp. (GROWMEND?+TX, GROWSWEET?+TX, Shootup?)+TX, bacteriophage of Clavipacter michiganensis (AgriPhage?)+TX, Bakflor?+TX, Beauveria bassiana (Beaugenic?+TX, Brocaril WP?)+TX, Beauveria bassiana GHA (Mycotrol ES?+TX, Mycotrol O?+TX, BotaniGuard?)+TX, Beauveria brongniartii (Engerlingspilz?+TX, Schweizer Beauveria?+TX, Melocont?)+TX, Beauveria spp.+TX, Botrytis cineria+TX, Bradyrhizobium japonicum (TerraMax?)+TX, Brevibacillus brevis+TX, Bacillus thuringiensis tenebrionis (Novodor?)+TX, BtBooster+TX, Burkholderia cepacia (Deny?+TX, Intercept?+TX, Blue Circle?)+TX, Burkholderia gladii+TX, Burkholderia gladioli+TX, Burkholderia spp.+TX, Canadian thistle fungus (CBH Canadian Bioherbicide?)+TX, Candida butyri+TX, Candida famata+TX, Candida fructus+TX, Candida glabrata+TX, Candida guilliermondii+TX, Candida melibiosica+TX, Candida oleophila strain O+TX, Candida parapsilosis+TX, Candida pelliculosa+TX, Candida pulcherrima+TX, Candida reukaufii+TX, Candida saitoana (Bio-Coat?+TX, Biocure?)+TX, Candida sake+TX, Candida spp.+TX, Candida tenius+TX, Cedecea dravisae+TX, Cellulomonas flavigena+TX, Chaetomium cochliodes (Nova-Cide?)+TX, Chaetomium globosum (Nova-Cide?)+TX, Chromobacterium subtsugae strain PRAA4-1T (Grandevo?)+TX, Cladosporium cladosporioides+TX, Cladosporium oxysporum+TX, Cladosporium chlorocephalum+TX, Cladosporium spp.+TX, Cladosporium tenuissimum+TX, Clonostachys rosea (EndoFine?)+TX, Colletotrichum acutatum+TX, Coniothyrium minitans (Cotans WG?)+TX, Coniothyrium spp.+TX, Cryptococcus albidus (YIELDPLUS?)+TX, Cryptococcus humicola+TX, Cryptococcus infirmo-miniatus+TX, Cryptococcus laurentii+TX, Cryptophlebia leucotreta granulovirus (Cryptex?)+TX, Cupriavidus campinensis+TX, Cydia pomonella granulovirus (CYD-X?)+TX, Cydia pomonella granulovirus (Madex?+TX, Madex Plus?+TX, Madex Max/Carpovirusine?)+TX, Cylindrobasidium laeve (Stumpout?)+TX, Cylindrocladium+TX, Debaryomyces i hansenii+TX, Drechslera hawaiinensis+TX, Enterobacter cloacae+TX, Enterobacteriaceae+TX, Entomophtora virulenta (Vektor?)+TX, Epicoccum nigrum+TX, Epicoccum purpurascens+TX, Epicoccum spp.+TX, Filobasidium floriforme+TX, Fusarium acuminatum+TX, Fusarium chlamydosporum+TX, Fusarium oxysporum (Fusaclean?/Biofox C?)+TX, Fusarium proliferatum+TX, Fusarium spp.+TX, Galactomyces geotrichum+TX, Gliocladium catenulatum (Primastop?+TX, Prestop?)+TX, Gliocladium roseum+TX, Gliocladium spp. (SoilGard?)+TX, Gliocladium virens (Soilgard?)+TX, Granulovirus (Granupom?)+TX, Halobacillus halophilus+TX, Halobacillus litoralis+TX, Halobacillus trueperi+TX, Halomonas spp.+TX, Halomonas subglaciescola+TX, Halovibrio variabilis+TX, Hanseniaspora uvarum+TX, Helicoverpa armigera nucleopolyhedrovirus (Helicovex?)+TX, Helicoverpa zea nuclear polyhedrosis virus (Gemstar?)+TX, Isoflavone-formononetin (Myconate?)+TX, Kloeckera apiculata+TX, Kloeckera spp.+TX, Lagenidium giganteum (Laginex?)+TX, Lecanicillium longisporum (Vertiblast?)+TX, Lecanicillium muscarium (Vertikil?)+TX, Lymantria Dispar nucleopolyhedrosis virus (Disparvirus?)+TX, Marinococcus halophilus+TX, Meira geulakonigii+TX, Metarhizium anisopliae (Met52?)+TX, Metarhizium anisopliae (Destruxin WP?)+TX, Metschnikowia fruticola (Shemer?)+TX, Metschnikowia pulcherrima+TX, Microdochium dimerum (Antibot?)+TX, Micromonospora coerulea+TX, Microsphaeropsis ochracea+TX, Muscodor albus 620 (Muscudor?)+TX, Muscodor roseus strain A3-5+TX, Mycorrhizae spp. (AMykor?+TX, Root Maximizer?)+TX, Myrothecium verrucaria strain AARC-0255 (DiTera?)+TX, BROS PLUS?+TX, Ophiostoma piliferum strain D97 (Sylvanex?)+TX, Paecilomyces farinosus+TX, Paecilomyces fumosoroseus (PFR-97?+TX, PreFeRal?)+TX, Paecilomyces linacinus (Biostat WP?)+TX, Paecilomyces lilacinus strain 251 (MeloCon WG?)+TX, Paenibacillus polymyxa+TX, Pantoea agglomerans (BlightBan C9-1?)+TX, Pantoea spp.+TX, Pasteuria spp. (Econem?)+TX, Pasteuria nishizawae+TX, Penicillium aurantiogriseum+TX, Penicillium billai (Jumpstart?+TX, TagTeam?)+TX, Penicillium brevicompactum+TX, Penicillium frequentans+TX, Penicillium griseofulvum+TX, Penicillium purpurogenum+TX, Penicillium spp.+TX, Penicillium viridicatum+TX, Phlebiopsis gigantean (Rotstop?)+TX, phosphate solubilizing bacteria (Phosphomeal?)+TX, Phytophthora cryptogea+TX, Phytophthora palmivora (Devine?)+TX, Pichia anomala+TX, Pichia guilermondii+TX, Pichia membranaefaciens+TX, Pichia onychis+TX, Pichia stipites+TX, Pseudomonas aeruginosa+TX, Pseudomonas aureofasciens (Spot-Less Biofungicide?)+TX, Pseudomonas cepacia+TX, Pseudomonas chlororaphis (AtEze?)+TX, Pseudomonas corrugate+TX, Pseudomonas fluorescens strain A506 (BlightBan A506?)+TX, Pseudomonas putida+TX, Pseudomonas reactans+TX, Pseudomonas spp.+TX, Pseudomonas syringae (Bio-Save?)+TX, Pseudomonas viridiflava+TX, Pseudomonas fluorescens (Zequanox?)+TX, Pseudozyma flocculosa strain PF-A22 UL (Sporodex L?)+TX, Puccinia canaliculata+TX, Puccinia thlaspeos (Wood Warrior?)+TX, Pythium paroecandrum+TX, Pythium oligandrum (Polygandron?+TX, Polyversum?)+TX, Pythium periplocum+TX, Rhanella aquatilis+TX, Rhanella spp.+TX, Rhizobia (Dormal?+TX, Vault?)+TX, Rhizoctonia+TX, Rhodococcus globerulus strain AQ719+TX, Rhodosporidium diobovatum+TX, Rhodosporidium toruloides+TX, Rhodotorula spp.+TX, Rhodotorula glutinis+TX, Rhodotorula graminis+TX, Rhodotorula mucilagnosa+TX, Rhodotorula rubra+TX, Saccharomyces cerevisiae+TX, Salinococcus roseus+TX, Sclerotinia minor+TX, Sclerotinia minor (SARRITOR?)+TX, Scytalidium spp.+TX, Scytalidium uredinicola+TX, Spodoptera exigua nuclear polyhedrosis virus (Spod-X?+TX, Spexit?)+TX, Serratia marcescens+TX, Serratia plymuthica+TX, Serratia spp.+TX, Sordaria fimicola+TX, Spodoptera littoralis nucleopolyhedrovirus (Littovir?)+TX, Sporobolomyces roseus+TX, Stenotrophomonas maltophilia+TX, Streptomyces ahygroscopicus+TX, Streptomyces albaduncus+TX, Streptomyces exfoliates+TX, Streptomyces galbus+TX, Streptomyces griseoplanus+TX, Streptomyces griseoviridis (Mycostop?)+TX, Streptomyces lydicus (Actinovate?)+TX, Streptomyces lydicus WYEC-108 (ActinoGrow?)+TX, Streptomyces violaceus+TX, Tilletiopsis minor+TX, Tilletiopsis spp.+TX, Trichoderma asperellum (T34 Biocontrol?)+TX, Trichoderma gamsii (Tenet?)+TX, Trichoderma atroviride (Plantmate?)+TX, Trichoderma hamatum TH 382+TX, Trichoderma harzianum rifai (Mycostar?)+TX, Trichoderma harzianum T-22 (Trianum-P?+TX, PlantShield HC?+TX, RootShield?+TX, Trianum-G?)+TX, Trichoderma harzianum T-39 (Trichodex?)+TX, Trichoderma inhamatum+TX, Trichoderma koningii+TX, Trichoderma spp. LC 52 (Sentinel?)+TX, Trichoderma lignorum+TX, Trichoderma longibrachiatum+TX, Trichoderma polysporum (Binab T?)+TX, Trichoderma taxi+TX, Trichoderma virens+TX, Trichoderma virens (formerly Gliocladium virens GL-21) (SoilGuard?)+TX, Trichoderma viride+TX, Trichoderma viride strain ICC 080 (Remedier?)+TX, Trichosporon pullulans+TX, Trichosporon spp.+TX, Trichothecium spp.+TX, Trichothecium roseum+TX, Typhula phacorrhiza strain 94670+TX, Typhula phacorrhiza strain 94671+TX, Ulocladium atrum+TX, Ulocladium oudemansii (Botry-Zen?)+TX, Ustilago maydis+TX, various bacteria and supplementary micronutrients (Natural II?)+TX, various fungi (Millennium Microbes?)+TX, Verticillium chlamydosporium+TX, Verticillium lecanii (Mycotal?+TX, Vertalec?)+TX, Vip3Aa20 (VIPtera?)+TX, Virgibaclillus marismortui+TX, Xanthomonas campestris pv. Poae (Camperico?)+TX, Xenorhabdus bovienii+TX, Xenorhabdus nematophilus; [0537] Plant extracts including: pine oil (Retenol?)+TX, azadirachtin (Plasma Neem Oil?+TX, AzaGuard?+TX, MeemAzal?+TX, Molt-X?+TX, Botanical IGR (Neemazad?+TX, Neemix?)+TX, canola oil (Lilly Miller Vegol?)+TX, Chenopodium ambrosioides near ambrosioides (Requiem?)+TX, Chrysanthemum extract (Crisant?)+TX, extract of neem oil (Trilogy?)+TX, essentials oils of Labiatae (Botania?)+TX, extracts of clove rosemary peppermint and thyme oil (Garden Insect Killer?)+TX, Glycinebetaine (Greenstim?)+TX, garlic+TX, lemongrass oil (GreenMatch?)+TX, neem oil+TX, Nepeta cataria (Catnip oil)+TX, Nepeta catarina+TX, nicotine+TX, oregano oil (MossBuster?)+TX, Pedaliaceae oil (Nematon?)+TX, pyrethrum+TX, Quillaja saponaria (NemaQ?)+TX, Reynoutria sachalinensis (Regalia?+TX, Sakalia?)+TX, rotenone (Eco Roten?)+TX, Rutaceae plant extract (Soleo?)+TX, soybean oil (Ortho Ecosense?)+TX, tea tree oil (Timorex Gold?)+TX, thymus oil+TX, AGNIQUE? MMF+TX, BugOil?+TX, mixture of rosemary sesame peppermint thyme and cinnamon extracts (EF 300?)+TX, mixture of clove rosemary and peppermint extract (EF 400?)+TX, mixture of clove peppermint garlic oil and mint (Soil Shot?)+TX, kaolin (Screen?)+TX, storage glucam of brown algae (Laminarin?); [0538] pheromones including: blackheaded fireworm pheromone (3M Sprayable Blackheaded Fireworm Pheromone?)+TX, Codling Moth Pheromone (Paramount dispenser-(CM)/Isomate C-Plus?)+TX, Grape Berry Moth Pheromone (3M MEC-GBM Sprayable Pheromone?)+TX, Leafroller pheromone (3M MEC-LR Sprayable Pheromone?)+TX, Muscamone (Snip7 Fly Bait?+TX, Starbar Premium Fly Bait?)+TX, Oriental Fruit Moth Pheromone (3M Oriental Fruit Moth Sprayable Pheromone?)+TX, Peachtree Borer Pheromone (Isomate-P?)+TX, Tomato Pinworm Pheromone (3M Sprayable Pheromone?)+TX, Entostat powder (extract from palm tree) (Exosex CM?)+TX, (E+TX,Z+TX,Z)-3+TX,8+TX,11 Tetradecatrienyl acetate+TX, (Z+TX,Z+TX,E)-7+TX,11+TX,13-Hexadecatrienal+TX, (E+TX,Z)-7+TX,9-Dodecadien-1-yl acetate+TX, 2-Methyl-1-butanol+TX, Calcium acetate+TX, Scenturion?+TX, Biolure?+TX, Check-Mate?+TX, Lavandulyl senecioate; [0539] Macrobials including: Aphelinus abdominalis+TX, Aphidius ervi (Aphelinus-System?)+TX, Acerophagus papaya+TX, Adalia bipunctata (Adalia-System?)+TX, Adalia bipunctata (Adaline?)+TX, Adalia bipunctata (Aphidalia?)+TX, Ageniaspis citricola+TX, Ageniaspis fuscicollis+TX, Amblyseius andersoni (Anderline?+TX, Andersoni-System?)+TX, Amblyseius californicus (Amblyline?+TX, Spical?)+TX, Amblyseius cucumeris (Thripex?+TX, Bugline Cucumeris?)+TX, Amblyseius fallacis (Fallacis?)+TX, Amblyseius swirskii (Bugline Swirskii?+TX, Swirskii-Mite?)+TX, Amblyseius womersleyi (WomerMite?)+TX, Amitus hesperidum+TX, Anagrus atomus+TX, Anagyrus fusciventris+TX, Anagyrus kamali+TX, Anagyrus loecki+TX, Anagyrus pseudococci (Citripar?)+TX, Anicetus benefices+TX, Anisopteromalus calandrae+TX, Anthocoris nemoralis (Anthocoris-System?)+TX, Aphelinus abdominalis (Apheline?+TX, Aphiline?)+TX, Aphelinus asychis+TX, Aphidius colemani (Aphipar?)+TX, Aphidius ervi (Ervipar?)+TX, Aphidius gifuensis+TX, Aphidius matricariae (Aphipar-M?)+TX, Aphidoletes aphidimyza (Aphidend?)+TX, Aphidoletes aphidimyza (Aphidoline?)+TX, Aphytis lingnanensis+TX, Aphytis melinus+TX, Aprostocetus hagenowii+TX, Atheta coriaria (Staphyline?)+TX, Bombus spp.+TX, Bombus terrestris (Natupol Beehive?)+TX, Bombus terrestris (Beeline?+TX, Tripol?)+TX, Cephalonomia stephanoderis+TX, Chilocorus nigritus+TX, Chrysoperla carnea (Chrysoline?)+TX, Chrysoperla carnea (Chrysopa?)+TX, Chrysoperla rufilabris+TX, Cirrospilus ingenuus+TX, Cirrospilus quadristriatus+TX, Citrostichus phyllocnistoides+TX, Closterocerus chamaeleon+TX, Closterocerus spp.+TX, Coccidoxenoides perminutus (Planopar?)+TX, Coccophagus cowperi+TX, Coccophagus lycimnia+TX, Cotesia flavipes+TX, Cotesia plutellae+TX, Cryptolaemus montrouzieri (Cryptobug?+TX, Cryptoline?)+TX, Cybocephalus nipponicus+TX, Dacnusa sibirica+TX, Dacnusa sibirica (Minusa?)+TX, Diglyphus isaea (Diminex?)+TX, Delphastus catalinae (Delphastus?)+TX, Delphastus pusillus+TX, Diachasmimorpha krausii+TX, Diachasmimorpha longicaudata+TX, Diaparsis jucunda+TX, Diaphorencyrtus aligarhensis+TX, Diglyphus isaea+TX, Diglyphus isaea (Miglyphus?+TX, Digline?)+TX, Dacnusa sibirica (DacDigline?+TX, Minex?)+TX, Diversinervus spp.+TX, Encarsia citrina+TX, Encarsia formosa (Encarsia Max?+TX, Encarline?+TX, En-Strip?)+TX, Eretmocerus eremicus (Enermix?)+TX, Encarsia guadeloupae+TX, Encarsia haitiensis+TX, Episyrphus balteatus (Syrphidend?)+TX, Eretmoceris siphonini+TX, Eretmocerus californicus+TX, Eretmocerus eremicus (Ercal?+TX, Eretline E?)+TX, Eretmocerus eremicus (Bemimix?)+TX, Eretmocerus hayati+TX, Eretmocerus mundus (Bemipar?+TX, Eretline M?)+TX, Eretmocerus siphonini+TX, Exochomus quadripustulatus+TX, Feltiella acarisuga (Spidend?)+TX, Feltiella acarisuga (Feltiline?)+TX, Fopius arisanus+TX, Fopius ceratitivorus+TX, Formononetin (Wirless Beehome?)+TX, Franklinothrips vespiformis (Vespop?)+TX, Galendromus occidentalis+TX, Goniozus legneri+TX, Habrobracon hebetor+TX, Harmonia axyridis (HarmoBeetle?)+TX, Heterorhabditis spp. (Lawn Patrol?)+TX, Heterorhabditis bacteriophora (NemaShield HB?+TX, Nemaseek?+TX, Terranem-Nam?+TX, Terranem?+TX, Larvanem?+TX, B-Green?+TX, NemAttack?+TX, Nematop?)+TX, Heterorhabditis megidis (Nemasys H?+TX, BioNem H?+TX, Exhibitline Hm?+TX, Larvanem-M?)+TX, Hippodamia convergens+TX, Hypoaspis aculeifer (Aculeifer-System?+TX, Entomite-A?)+TX, Hypoaspis miles (Hypoline M?+TX, Entomite-M?)+TX, Lbalia leucospoides+TX, Lecanoideus floccissimus+TX, Lemophagus errabundus+TX, Leptomastidea abnormis+TX, Leptomastix dactylopii (Leptopar?)+TX, Leptomastix epona+TX, Lindorus lophanthae+TX, Lipolexis oregmae+TX, Lucilia caesar (Natufly?)+TX, Lysiphlebus testaceipes+TX, Macrolophus caliginosus (Mirical-N?+TX, Macroline C?+TX, Mirical?)+TX, Mesoseiulus longipes+TX, Metaphycus flavus+TX, Metaphycus lounsburyi+TX, Micromus angulatus (Milacewing?)+TX, Microterys flavus+TX, Muscidifurax raptorellus and Spalangia cameroni (Biopar?)+TX, Neodryinus typhlocybae+TX, Neoseiulus californicus+TX, Neoseiulus cucumeris (THRYPEX?)+TX, Neoseiulus fallacis+TX, Nesideocoris tenuis (NesidioBug?+TX, Nesibug?)+TX, Ophyra aenescens (Biofly?)+TX, Orius insidiosus (Thripor-I?+TX, Oriline i?)+TX, Orius laevigatus (Thripor-L?+TX, Oriline I?)+TX, Orius majusculus (Oriline M?)+TX, Orius strigicollis (Thripor-S?)+TX, Pauesia juniperorum+TX, Pediobius foveolatus+TX, Phasmarhabditis hermaphrodita (Nemaslug?)+TX, Phymastichus coffea+TX, Phytoseiulus macropilus+TX, Phytoseiulus persimilis (Spidex?+TX, Phytoline P?)+TX, Podisus maculiventris (Podisus?)+TX, Pseudacteon curvatus+TX, Pseudacteon obtusus+TX, Pseudacteon tricuspis+TX, Pseudaphycus maculipennis+TX, Pseudleptomastix mexicana+TX, Psyllaephagus pilosus+TX, Psyttalia concolor (complex)+TX, Quadrastichus spp.+TX, Rhyzobius lophanthae+TX, Rodolia cardinalis+TX, Rumina decollate+TX, Semielacher petiolatus+TX, Sitobion avenae (Ervibank?)+TX, Steinernema carpocapsae (Nematac C?+TX, Millenium?+TX, BioNem C?+TX, NemAttack?+TX, Nemastar?+TX, Capsanem?)+TX, Steinernema feltiae (NemaShield?+TX, Nemasys F?+TX, BioNem F?+TX, Steinernema-System?+TX, NemAttack?+TX, Nemaplus?+TX, Exhibitline Sf?+TX, Scia-Rid?+TX, Entonem?)+TX, Steinernema kraussei (Nemasys L?+TX, BioNem L?+TX, Exhibitline Srb?)+TX, Steinernema riobrave (BioVector?+TX, BioVektor?)+TX, Steinernema scapterisci (Nematac S?)+TX, Steinernema spp.+TX, Steinernematid spp. (Guardian Nematodes?)+TX, Stethorus punctillum (Stethorus?)+TX, Tamarixia radiate+TX, Tetrastichus setifer+TX, Thripobius semiluteus+TX, Torymus sinensis+TX, Trichogramma brassicae (Tricholine B?)+TX, Trichogramma brassicae (Tricho-Strip?)+TX, Trichogramma evanescens+TX, Trichogramma minutum+TX, Trichogramma ostriniae+TX, Trichogramma platneri+TX, Trichogramma pretiosum+TX, Xanthopimpla stemmator; [0540] other biologicals including: abscisic acid+TX, bioSea?+TX, Chondrostereum purpureum (Chontrol Paste?)+TX, Colletotrichum gloeosporioides (Collego?)+TX, Copper Octanoate (Cueva?)+TX, Delta traps (Trapline D?)+TX, Erwinia amylovora (Harpin) (ProAct?+TX, Ni-HIBIT Gold CST?)+TX, fatty acids derived from a natural by-product of extra virgin olive oil (FLIPPER?)+TX, Ferri-phosphate (Ferramol?)+TX, Funnel traps (Trapline Y?)+TX, Gallex?+TX, Grower's Secret?+TX, Homo-brassonolide+TX, Iron Phosphate (Lilly Miller Worry Free Ferramol Slug & Snail Bait?)+TX, MCP hail trap (Trapline F?)+TX, Microctonus hyperodae+TX, Mycoleptodiscus terrestris (Des-X?)+TX, BioGain?+TX, Aminomite?+TX, Zenox?+TX, Pheromone trap (Thripline Ams?)+TX, potassium bicarbonate (MilStop?)+TX, potassium salts of fatty acids (Sanova?)+TX, potassium silicate solution (Sil-Matrix?)+TX, potassium iodide+potassiumthiocyanate (Enzicur?)+TX, SuffOil-X?+TX, Spider venom+TX, Nosema locustae (Semaspore Organic Grasshopper Control?)+TX, Sticky traps (Trapline YF?+TX, Rebell Amarillo?)+TX and Traps (Takitrapline y+B?)+TX; [0541] (1) antibacterial agents selected from the group of: [0542] (1.1) bacteria, examples of which are Bacillus mojavensis strain R3B (Accession No. NCAIM (P) B001389) (WO 2013/034938) from Certis USA LLC, a subsidiary of Mitsui & Co.+TX; Bacillus pumilus, in particular strain BU F-33, having NRRL Accession No. 50185 (available as part of the CARTISSA? product from BASF, EPA Reg. No. 71840-19)+TX; Bacillus subtilis, in particular strain QST713/AQ713 (available as SERENADE OPTI or SERENADE ASO from Bayer CropScience LP, US, having NRRL Accession No. B21661, U.S. Pat. No. 6,060,051)+TX; Bacillus subtilis strain BU1814, (available as VELONDIS? PLUS, VELONDIS? FLEX and VELONDIS? EXTRA from BASF SE)+TX; Bacillus subtilis var. amyloliquefaciens strain FZB24 having Accession No. DSM 10271 (available from Novozymes as TAEGRO? or TAEGRO? ECO (EPA Registration No. 70127-5))+TX; Bacillus subtilis CX-9060 from Certis USA LLC, a subsidiary of Mitsui & Co.+TX; Bacillus sp., in particular strain D747 (available as DOUBLE NICKEL? from Kumiai Chemical Industry Co., Ltd.), having Accession No. FERM BP-8234, U.S. Pat. No. 7,094,592+TX; Paenibacillus sp. strain having Accession No. NRRL B-50972 or Accession No. NRRL B-67129, WO 2016/154297+TX; Paenibacillus polymyxa, in particular strain AC-1 (e.g. TOPSEED? from Green Biotech Company Ltd.)+TX; Pantoea agglomerans, in particular strain E325 (Accession No. NRRL B-21856) (available as BLOOMTIME BIOLOGICAL? FD BIOPESTICIDE from Northwest Agri Products)+TX; Pseudomonas proradix (e.g. PRORADIX? from Sourcon Padena)+TX; and [0543] (1.2) fungi, examples of which are Aureobasidium pullulans, in particular blastospores of strain DSM14940, blastospores of strain DSM 14941 or mixtures of blastospores of strains DSM14940 and DSM14941 (e.g., BOTECTOR? and BLOSSOM PROTECT? from bio-ferm, CH)+TX; Pseudozyma aphidis (as disclosed in WO2011/151819 by Yissum Research Development Company of the Hebrew University of Jerusalem)+TX; Saccharomyces cerevisiae, in particular strains CNCM No. 1-3936, CNCM No. 1-3937, CNCM No. 1-3938 or CNCM No. 1-3939 (WO 2010/086790) from Lesaffre et Compagnie, FR; [0544] (2) biological fungicides selected from the group of: [0545] (2.1) bacteria, examples of which are Agrobacterium radiobacter strain K84 (e.g. GALLTROL-A? from AgBioChem, CA)+TX; Agrobacterium radiobacter strain K1026 (e.g. NOGALL? from BASF SE)+TX; Bacillus subtilis var. amyloliquefaciens strain FZB24 having Accession No. DSM 10271 (available from Novozymes as TAEGRO? or TAEGRO? ECO (EPA Registration No. 70127-5))+TX; Bacillus amyloliquefaciens, in particular strain D747 (available as Double Nickel? from Kumiai Chemical Industry Co., Ltd., having accession number FERM BP-8234, U.S. Pat. No. 7,094,592)+TX; Bacillus amyloliquefaciens strain F727 (also known as strain MB1110) (NRRL Accession No. B-50768, WO 2014/028521) (STARGUS? from Marrone Bio Innovations)+TX; Bacillus amyloliquefaciens strain FZB42, Accession No. DSM 23117 (available as RHIZOVITAL? from ABiTEP, DE)+TX; Bacillus amyloliquefaciens isolate B246 (e.g. AVOGREEN? from University of Pretoria)+TX; Bacillus licheniformis, in particular strain SB3086, having Accession No. ATCC 55406, WO 2003/000051 (available as ECOGUARD? Biofungicide and GREEN RELEAF? from Novozymes)+TX+TX; Bacillus licheniformis FMCH001 and Bacillus subtilis FMCH002 (QUARTZO? (WG) and PRESENCE? (WP) from FMC Corporation)+TX; Bacillus methylotrophicus strain BAC-9912 (from Chinese Academy of Sciences' Institute of Applied Ecology)+TX; Bacillus mojavensis strain R3B (Accession No. NCAIM (P) B001389) (WO 2013/034938) from Certis USA LLC, a subsidiary of Mitsui & Co.+TX; Bacillus mycoides, isolate, having Accession No. B-30890 (available as BMJ TGAI? or WG and LifeGard? from Certis USA LLC, a subsidiary of Mitsui & Co.)+TX; Bacillus pumilus, in particular strain QST2808 (available as SONATA? from Bayer CropScience LP, US, having Accession No. NRRL B-30087 and described in U.S. Pat. No. 6,245,551)+TX; Bacillus pumilus, in particular strain GB34 (available as Yield Shield? from Bayer AG, DE)+TX; Bacillus pumilus, in particular strain BU F-33, having NRRL Accession No. 50185 (available as part of the CARTISSA product from BASF, EPA Reg. No. 71840-19)+TX; Bacillus subtilis, in particular strain QST713/AQ713 (available as SERENADE OPTI or SERENADE ASO from Bayer CropScience LP, US, having NRRL Accession No. B21661 and described in U.S. Pat. No. 6,060,051)+TX; Bacillus subtilis Y1336 (available as BIOBAC? WP from Bion-Tech, Taiwan, registered as a biological fungicide in Taiwan under Registration Nos. 4764, 5454, 5096 and 5277)+TX; Bacillus subtilis strain MBI 600 (available as SUBTILEX from BASF SE), having Accession Number NRRL B-50595, U.S. Pat. No. 5,061,495+TX; Bacillus subtilis strain GB03 (available as Kodiak? from Bayer AG, DE)+TX; Bacillus subtilis strain BU1814, (available as VELONDIS? PLUS, VELONDIS? FLEX and VELONDIS? EXTRA from BASF SE)+TX; Bacillus subtilis CX-9060 from Certis USA LLC, a subsidiary of Mitsui & Co.+TX; Bacillus subtilis KTSB strain (FOLIACTIVE? from Donaghys)+TX; Bacillus subtilis IAB/BS03 (AVIV? from STK Bio-Ag Technologies, PORTENTO? from Idai Nature)+TX; Bacillus subtilis strain Y1336 (available as BIOBAC? WP from Bion-Tech, Taiwan, registered as a biological fungicide in Taiwan under Registration Nos. 4764, 5454, 5096 and 5277)+TX; Paenibacillus epiphyticus (WO 2016/020371) from BASF SE+TX; Paenibacillus polymyxa ssp. plantarum (WO 2016/020371) from BASF SE+TX; Paenibacillus sp. strain having Accession No. NRRL B-50972 or Accession No. NRRL B-67129, WO 2016/154297+TX; Pseudomonas chlororaphis strain AFS009, having Accession No. NRRL B-50897, WO 2017/019448 (e.g., HOWLER? and ZIO? from AgBiome Innovations, US)+TX; Pseudomonas chlororaphis, in particular strain MA342 (e.g. CEDOMON?, CERALL?, and CEDRESS? by Bioagri and Koppert)+TX; Pseudomonas fluorescens strain A506 (e.g. BLIGHTBAN? A506 by NuFarm)+TX; Pseudomonas proradix (e.g. PRORADIX? from Sourcon Padena)+TX; Streptomyces griseoviridis strain K61 (also known as Streptomyces galbus strain K61) (Accession No. DSM 7206) (MYCOSTOP? from Verdera, PREFENCE? from BioWorks, cf. Crop Protection 2006, 25, 468-475)+TX; Streptomyces lydicus strain WYEC108 (also known as Streptomyces lydicus strain WYCD108US) (ACTINO-IRON? and ACTINOVATE? from Novozymes)+TX; and [0546] (2.2) fungi, examples of which are Ampelomyces quisqualis, in particular strain AQ 10 (e.g. AQ 10? by IntrachemBio Italia)+TX; Ampelomyces quisqualis strain AQ10, having Accession No. CNCM 1-807 (e.g., AQ 10? by IntrachemBio Italia)+TX; Aspergillus flavus strain NRRL 21882 (products known as AFLA-GUARD? from Syngenta/ChemChina)+TX; Aureobasidium pullulans, in particular blastospores of strain DSM14940+TX; Aureobasidium pullulans, in particular blastospores of strain DSM 14941+TX; Aureobasidium pullulans, in particular mixtures of blastospores of strains DSM14940 and DSM 14941 (e.g. Botector? by bio-ferm, CH)+TX; Chaetomium cupreum (Accession No. CABI 353812) (e.g. BIOKUPRUM? by AgriLife)+TX; Chaetomium globosum (available as RIVADIOM? by Rivale)+TX; Cladosporium cladosporioides, strain H39, having Accession No. CBS122244, US 2010/0291039 (by Stichting Dienst Landbouwkundig Onderzoek)+TX; Coniothyrium minitans, in particular strain CON/M/91-8 (Accession No. DSM9660, e.g. Contans? from Bayer CropScience Biologics GmbH)+TX; Cryptococcus flavescens, strain 3C (NRRL Y-50378), (B2.2.99)+TX; Dactylaria candida+TX; Dilophosphora alopecuri (available as TWIST FUNGUS?)+TX; Fusarium oxysporum, strain Fo47 (available as FUSACLEAN? by Natural Plant Protection)+TX; Gliocladium catenulatum (Synonym: Clonostachys rosea f. catenulate) strain J1446 (e.g. Prestop? by Lallemand)+TX; Gliocladium roseum (also known as Clonostachys rosea f rosea), in particular strain 321U from Adjuvants Plus, strain ACM941 as disclosed in Xue (Efficacy of Clonostachys rosea strain ACM941 and fungicide seed treatments for controlling the root tot complex of field pea, Can Jour Plant Sci 83(3): 519-524), or strain IK726 (Jensen D F, et al. Development of a biocontrol agent for plant disease control with special emphasis on the near commercial fungal antagonist Clonostachys rosea strain IK726, Australas Plant Pathol. 2007,36:95-101)+TX; Lecanicillium lecanii (formerly known as Verticillium lecanii) conidia of strain KV01 (e.g. Vertalec? by Koppert/Arysta)+TX; Metschnikowia fructicola, in particular strain NRRL Y-30752, (B2.2.3)+TX; Microsphaeropsis ochracea+TX; Muscodor roseus, in particular strain A3-5 (Accession No. NRRL 30548)+TX; Penicillium steckii (DSM 27859, WO 2015/067800) from BASF SE+TX; Penicillium vermiculatum+TX; Phlebiopsis gigantea strain VRA 1992 (ROTSTOP? C from Danstar Ferment)+TX; Pichia anomala, strain WRL-076 (NRRL Y-30842), U.S. Pat. No. 7,579,183+TX; Pseudozyma flocculosa, strain PF-A22 UL (available as SPORODEX? L by Plant Products Co., CA)+TX; Saccharomyces cerevisiae, in particular strain LASO2 (from Agro-Levures et D?riv?s), strain LAS117 cell walls (CEREVISANE? from Lesaffre, ROMEO? from BASF SE), strains CNCM No. 1-3936, CNCM No. 1-3937, CNCM No. 1-3938, CNCM No. 1-3939 (WO 2010/086790) from Lesaffre et Compagnie, FR+TX; Simplicillium lanosoniveum+TX; Talaromyces flavus, strain V117b+TX; Trichoderma asperelloides JM41R (Accession No. NRRL B-50759) (TRICHO PLUS? from BASF SE)+TX; Trichoderma asperellum, in particular, strain kd (e.g. T-Gro from Andermatt Biocontrol)+TX; Trichoderma asperellum, in particular strain SKT-1, having Accession No. FERM P-16510 (e.g. ECO-HOPE? from Kumiai Chemical Industry), strain T34 (e.g. T34 Biocontrol by Biocontrol Technologies S.L., ES) or strain ICC 012 from Isagro+TX; Trichoderma atroviride, in particular strain SC1 (having Accession No. CBS 122089, WO 2009/116106 and U.S. Pat. No. 8,431,120 (from Bi-PA)), strain 77B (T77 from Andermatt Biocontrol) or strain LU132 (e.g. Sentinel from Agrimm Technologies Limited)+TX; Trichoderma atroviride, strain CNCM 1-1237 (e.g. Esquive? WP from Agrauxine, FR)+TX; Trichoderma atroviride, strain no. V08/002387+TX; Trichoderma atroviride, strain NMI no. V08/002388+TX; Trichoderma atroviride, strain NMI no. V08/002389+TX; Trichoderma atroviride, strain NMI no. V08/002390+TX; Trichoderma atroviride, strain LC52 (e.g. Tenet by Agrimm Technologies Limited)+TX; Trichoderma atroviride, strain ATCC 20476 (IMI 206040)+TX; Trichoderma atroviride, strain T11 (IM1352941/CECT20498)+TX; Trichoderma atroviride, strain SKT-1 (FERM P-16510), JP Patent Publication (Kokai) 11-253151 A+TX; Trichoderma atroviride, strain SKT-2 (FERM P-16511), JP Patent Publication (Kokai) 11-253151 A+TX; Trichoderma atroviride, strain SKT-3 (FERM P-17021), JP Patent Publication (Kokai) 11-253151 A+TX; Trichoderma fertile (e.g. product TrichoPlus from BASF)+TX; Trichoderma gamsii (formerly T. viride), strain ICC080 (IMI CC 392151 CABI, e.g. BioDerma by AGROBIOSOL DE MEXICO, S.A. DE C.V.)+TX; Trichoderma gamsii (formerly T. viride), strain ICC 080 (IMI CC 392151 CABI) (available as BIODERMA? by AGROBIOSOL DE MEXICO, S.A. DE C.V.)+TX; Trichoderma harmatum+TX; Trichoderma harmatum, having Accession No. ATCC 28012+TX; Trichoderma harzianum strain T-22 (e.g. Trianum-P from Andermatt Biocontrol or Koppert) or strain Cepa SimbT5 (from Simbiose Agro)+TX; Trichoderma harzianum+TX; Trichoderma harzianum rifai T39 (e.g. Trichodex? from Makhteshim, US)+TX; Trichoderma harzianum, strain ITEM 908 (e.g. Trianum-P from Koppert)+TX; Trichoderma harzianum, strain TH35 (e.g. Root-Pro by Mycontrol)+TX; Trichoderma harzianum, strain DB 103 (available as T-GRO? 7456 by Dagutat Biolab)+TX; Trichoderma polysporum, strain IMI 206039 (e.g. Binab TF WP by BINAB Bio-Innovation AB, Sweden)+TX; Trichoderma stromaticum, having Accession No. Ts3550 (e.g. Tricovab by CEPLAC, Brazil)+TX; Trichoderma virens (also known as Gliocladium virens), in particular strain GL-21 (e.g. SoilGard by Certis, US)+TX; Trichoderma virens strain G-41, formerly known as Gliocladium virens (Accession No. ATCC 20906) (e.g., ROOTSHIELD? PLUS WP and TURFSHIELD? PLUS WP from BioWorks, US)+TX; Trichoderma viride, strain TV1 (e.g. Trianum-P by Koppert)+TX; Trichoderma viride, in particular strain B35 (Pietr et al., 1993, Zesz. Nauk. A R w Szczecinie 161: 125-137)+TX; mixtures of Trichoderma asperellum strain ICC 012 (also known as Trichoderma harzianum ICC012), having Accession No. CABI CC IMI 392716 and Trichoderma gamsii (formerly T. viride) strain ICC 080, having Accession No. IMI 392151 (e.g., BIO-TAM? from Isagro USA, Inc. and BIODERMA? by Agrobiosol de Mexico, S.A. de C.V.)+TX; Ulocladium oudemansii strain U3, having Accession No. NM 99/06216 (e.g., BOTRY-ZEN? by Botry-Zen Ltd, New Zealand and BOTRYSTOP? from BioWorks, Inc.)+TX; Verticillium albo-atrum (formerly V. dahliae), strain WCS850 having Accession No. WCS850, deposited at the Central Bureau for Fungi Cultures (e.g., DUTCH TRIG? by Tree Care Innovations)+TX; Verticillium chlamydosporium+TX; [0547] (3) biological control agents having an effect for improving plant growth and/or plant health selected from the group of: [0548] (3.1) bacteria, examples of which are Azospirillum brasilense (e.g., VIGOR? from KALO, Inc.)+TX; Azospirillum lipoferum (e.g., VERTEX-IF? from TerraMax, Inc.)+TX; Azorhizobium caulinodans, in particular strain ZBSK-5+TX; Azotobacter chroococcum, in particular strain H23+TX; Azotobacter vinelandii, in particular strain ATCC 12837+TX; a mixture of Azotobacter vinelandii and Clostridium pasteurianum (available as INVIGORATE? from Agrinos)+TX; Bacillus amyloliquefaciens ?m414 (LOLI-PEPTA? from Biofilm Crop Protection)+TX; Bacillus amyloliquefaciens SB3281 (ATCC #PTA-7542, WO 2017/205258)+TX; Bacillus amyloliquefaciens TJ1000 (available as QUIKROOTS? from Novozymes)+TX; Bacillus amyloliquefaciens, in particular strain IN937a+TX; Bacillus amyloliquefaciens, in particular strain FZB42 (e.g. RHIZOVITAL? from ABiTEP, DE)+TX; Bacillus amyloliquefaciens BS27 (Accession No. NRRL B-5015)+TX; Bacillus cereus family member EE128 (NRRL No. B-50917)+TX; Bacillus cereus family member EE349 (NRRL No. B-50928)+TX; Bacillus cereus, in particular strain BPO1 (ATCC 55675, e.g. MEPICHLOR? from Arysta Lifescience, US)+TX; Bacillus firmus, in particular strain CNMC 1-1582 (e.g. VOTIVO? from BASF SE)+TX; Bacillus mycoides BT155 (NRRL No. B-50921)+TX; Bacillus mycoides EE118 (NRRL No. B-50918)+TX; Bacillus mycoides EE141 (NRRL No. B-50916)+TX; Bacillus mycoides BT46-3 (NRRL No. B-50922)+TX; Bacillus pumilus, in particular strain QST2808 (having Accession No. NRRL No. B-30087)+TX; Bacillus pumilus, in particular strain GB34 (e.g. YIELD SHIELD? from Bayer Crop Science, DE)+TX; Bacillus siamensis, in particular strain KCTC 13613T+TX; Bacillus subtilis, in particular strain QST713/AQ713 (having NRRL Accession No. B-21661 and described in U.S. Pat. No. 6,060,051, available as SERENADE? OPTI or SERENADE? ASO from Bayer CropScience LP, US)+TX; Bacillus subtilis, in particular strain AQ30002 (having Accession Nos. NRRL B-50421 and described in U.S. patent application Ser. No. 13/330,576)+TX; Bacillus subtilis, in particular strain AQ30004 (and NRRL B-50455 and described in U.S. patent application Ser. No. 13/330,576)+TX; Bacillus subtilis strain BU1814, (available as TEQUALIS? from BASF SE), Bacillus subtilis rm303 (RHIZOMAX? from Biofilm Crop Protection)+TX; Bacillus thuringiensis BT013A (NRRL No. B-50924) also known as Bacillus thuringiensis 4Q7+TX; a mixture of Bacillus licheniformis FMCH001 and Bacillus subtilis FMCH002 (available as QUARTZO? (WG), PRESENCE? (WP) from FMC Corporation)+TX; Bacillus subtilis, in particular strain MBI 600 (e.g. SUBTILEX? from BASF SE)+TX; Bacillus tequilensis, in particular strain NII-0943+TX; Bradyrhizobium japonicum (e.g. OPTIMIZE? from Novozymes)+TX; Delftia acidovorans, in particular strain RAY209 (e.g. BIOBOOST? from Brett Young Seeds)+TX; Mesorhizobium cicer (e.g., NODULATOR from BASF SE)+TX; Lactobacillus sp. (e.g. LACTOPLANT? from LactoPAFI)+TX; Rhizobium leguminosarium biovar viciae (e.g., NODULATOR from BASF SE)+TX; Pseudomonas proradix (e.g. PRORADIX? from Sourcon Padena)+TX; Pseudomonas aeruginosa, in particular strain PN1+TX; Rhizobium leguminosarum, in particular bv. viceae strain Z25 (Accession No. CECT 4585)+TX; Paenibacillus polymyxa, in particular strain AC-1 (e.g. TOPSEED? from Green Biotech Company Ltd.)+TX; Serratia marcescens, in particular strain SRM (Accession No. MTCC 8708)+TX; Sinorhizobium meliloti strain NRG-185-1 (NITRAGIN? GOLD from Bayer CropScience)+TX; Thiobacillus sp. (e.g. CROPAID? from Cropaid Ltd UK)+TX; and (3.2) fungi, examples of which are Purpureocillium lilacinum (previously known as Paecilomyces lilacinus) strain 251 (AGAL 89/030550, e.g. BioAct from Bayer CropScience Biologics GmbH)+TX; Penicillium bilaii, strain ATCC 22348 (e.g. JumpStart? from Acceleron BioAg), Talaromyces flavus, strain V117b+TX; Trichoderma atroviride strain CNCM 1-1237 (e.g. Esquive? WP from Agrauxine, FR), Trichoderma viride, e.g. strain B35 (Pietr et al., 1993, Zesz. Nauk. A R w Szczecinie 161: 125-137)+TX; Trichoderma atroviride strain LC52 (also known as Trichoderma atroviride strain LU132, e.g. Sentinel from Agrimm Technologies Limited)+TX; Trichoderma atroviride strain SC1 described in International Application No. PCT/IT2008/000196)+TX; Trichoderma asperellum strain kd (e.g. T-Gro from Andermatt Biocontrol)+TX; Trichoderma asperellum strain Eco-T (Plant Health Products, ZA), Trichoderma harzianum strain T-22 (e.g. Trianum-P from Andermatt Biocontrol or Koppert)+TX; Myrothecium verrucaria strain AARC-0255 (e.g. DiTera? from Valent Biosciences)+TX; Penicillium bilaii strain ATCC ATCC20851+TX; Pythium oligandrum strain M1 (ATCC 38472, e.g. Polyversum from Bioprepraty, CZ)+TX; Trichoderma virens strain GL-21 (e.g. SoilGard? from Certis, USA)+TX; Verticillium albo-atrum (formerly V. dahliae) strain WCS850 (CBS 276.92, e.g. Dutch Trig from Tree Care Innovations)+TX; Trichoderma atroviride, in particular strain no. V08/002387, strain no. NMI No. V08/002388, strain no. NMI No. V08/002389, strain no. NMI No. V08/002390+TX; Trichoderma harzianum strain ITEM 908, Trichoderma harzianum, strain TSTh20+TX; Trichoderma harzianum strain 1295-22+TX; Pythium oligandrum strain DV74+TX; Rhizopogon amylopogon (e.g. comprised in Myco-Sol from Helena Chemical Company)+TX; Rhizopogon fulvigleba (e.g. comprised in Myco-Sol from Helena Chemical Company)+TX; Trichoderma virens strain GI-3+TX; [0549] (4) insecticidally active biological control agents selected from [0550] (4.1) bacteria, examples of which are Agrobacterium radiobacter strain K84 (Galltrol from AgBiochem Inc.)+TX; Bacillus amyloliquefaciens, in particular strain PTS-4838 (e.g. AVEO from Valent Biosciences, US)+TX; Bacillus firmus, in particular strain CNMC 1-1582 (e.g. VOTIVO? from BASF SE)+TX; Bacillus mycoides, isolate J. (e.g. BmJ from Certis USA LLC, a subsidiary of Mitsui & Co.)+TX; Bacillus sphaericus, in particular Serotype H5a5b strain 2362 (strain ABTS-1743) (e.g. VECTOLEX? from Valent BioSciences, US)+TX; Bacillus thuringiensis subsp. aizawai, in particular strain ABTS-1857 (SD-1372, e.g. XENTARI? from Valent BioSciences)+TX; Bacillus thuringiensis subsp. aizawai, in particular serotype H-7 (e.g. FLORBAC? WG from Valent BioSciences, US)+TX; Bacillus thuringiensis israelensis strain BMP 144 (e.g. AQUABAC? by Becker Microbial Products IL)+TX; Bacillus thuringiensis subsp. israelensis (serotype H-14) strain AM65-52 (Accession No. ATCC 1276) (e.g. VECTOBAC? by Valent BioSciences, US)+TX; Bacillus thuringiensis subsp. aizawai strain GC-91+TX; Bacillus thuringiensis var. Colmeri (e.g. TIANBAOBTC by Changzhou Jianghai Chemical Factory)+TX; Bacillus thuringiensis var. japonensis strain Buibui+TX; Bacillus thuringiensis subsp. kurstaki strain BMP 123 from Becker Microbial Products, IL+TX; Bacillus thuringiensis subsp. kurstaki strain BMP 123 by Becker Microbial Products, IL, e.g. BARITONE from Bayer CropScience+TX; Bacillus thuringiensis subsp. kurstaki strain HD-1 (e.g. DIPEL? ES from Valent BioSciences, US)+TX; Bacillus thuringiensis var. kurstaki strain EVB-113-19 (e.g., BIOPROTEC? from AEF Global)+TX; Bacillus thuringiensis subsp. kurstaki strain ABTS 351+TX; Bacillus thuringiensis subsp. kurstaki strain PB 54+TX; Bacillus thuringiensis subsp. kurstaki strain SA 11, (JAVELIN from Certis, US)+TX; Bacillus thuringiensis subsp. kurstaki strain SA 12 (THURICIDE from Certis, US)+TX; Bacillus thuringiensis subsp. kurstaki strain EG 2348 (LEPINOX from Certis, US)+TX; Bacillus thuringiensis subsp. kurstaki strain EG 7841 (CRYMAX from Certis, US)+TX; Bacillus thuringiensis subsp. tenebrionis strain NB 176 (SD-5428, e.g. NOVODOR? FC from BioFa DE)+TX; Brevibacillus laterosporus (LATERAL from Ecolibrium Biologicals)+TX; Burkholderia spp., in particular Burkholderia rinojensis strain A396 (also known as Burkholderia rinojensis strain MBI 305) (Accession No. NRRL B-50319+TX; WO 2011/106491 and WO 2013/032693+TX; e.g. MB1206 TGAI and ZELTO? from Marrone Bio Innovations)+TX; Chromobacterium subtsugae, in particular strain PRAA4-1T (MBI-203+TX; e.g. GRANDEVO? from Marrone Bio Innovations)+TX; Lecanicillium muscarium Ve6 (MYCOTAL from Koppert)+TX; Paenibacillus popilliae (formerly Bacillus popilliae+TX; e.g. MILKY SPORE POWDER? and MILKY SPORE GRANULAR? from St. Gabriel Laboratories)+TX; Pasteuria nishizawae strain Pn1 (CLARIVA from Syngenta/ChemChina)+TX; Serratia entomophila (e.g. INVADE? by Wrightson Seeds)+TX; Serratia marcescens, in particular strain SRM (Accession No. MTCC 8708)+TX; Trichoderma asperellum (TRICHODERMAX from Novozymes)+TX; Wolbachia pipientis ZAP strain (e.g., ZAP MALES? from MosquitoMate)+TX; and [0551] (4.2) fungi, examples of which are Beauveria bassiana strain ATCC 74040 (e.g. NATURALIS? from Intrachem Bio Italia)+TX; Beauveria bassiana strain GHA (Accession No. ATCC74250, e.g. BOTANIGUARD? ES and MYCONTROL-O? from Laverlam International Corporation)+TX; Beauveria bassiana strain ATP02 (Accession No. DSM 24665)+TX; Isaria fumosorosea (previously known as Paecilomyces fumosoroseus) strain Apopka 97) PREFERAL from SePRO+TX; Metarhizium anisopliae 3213-1 (deposited under NRRL accession number 67074) (WO 2017/066094+TX; Pioneer Hi-Bred International)+TX; Metarhizium robertsii 15013-1 (deposited under NRRL accession number 67073)+TX; Metarhizium robertsii 23013-3 (deposited under NRRL accession number 67075)+TX; Paecilomyces lilacinus strain 251 (MELOCON from Certis, US)+TX; Zoophtora radicans+TX; [0552] (5) Viruses selected from the group consisting of Adoxophyes orana (summer fruit tortrix) granulosis virus (GV)+TX; Cydia pomonella (codling moth) granulosis virus (GV)+TX; Helicoverpa armigera (cotton bollworm) nuclear polyhedrosis virus (NPV)+TX; Spodoptera exigua (beet armyworm) mNPV+TX; Spodoptera frugiperda (fall armyworm) mNPV+TX; Spodoptera littoralis (African cotton leafworm) NPV+TX; [0553] (6) Bacteria and fungi which can be added as inoculant to plants or plant parts or plant organs and which, by virtue of their particular properties, promote plant growth and plant health selected from Agrobacterium spp.+TX; Azorhizobium caulinodans+TX; Azospirillum spp.+TX; Azotobacter spp.+TX; Bradyrhizobium spp.+TX; Burkholderia spp., in particular Burkholderia cepacia (formerly known as Pseudomonas cepacia)+TX; Gigaspora spp., or Gigaspora monosporum+TX; Glomus spp.+TX; Laccaria spp.+TX; LactoBacillus buchneri+TX; Paraglomus spp.+TX; Pisolithus tinctorus+TX; Pseudomonas spp.+TX; Rhizobium spp., in particular Rhizobium trifolii+TX; Rhizopogon spp.+TX; Scleroderma spp.+TX; Suillus spp.+TX; Streptomyces spp.+TX; [0554] (7) Plant extracts and products formed by microorganisms including proteins and secondary metabolites which can be used as biological control agents, selected from Allium sativum (NEMGUARD from Eco-Spray+TX; BRALIC from ADAMA)+TX; Armour-Zen+TX; Artemisia absinthium+TX; Azadirachtin (e.g. AZATIN XL from Certis, US)+TX; Biokeeper WP+TX; Brassicaceae extract, in particular oilseed rape powder or mustard powder+TX; Cassia nigricans+TX; Celastrus angulatus+TX; Chenopodium anthelminticum+TX; Chitin+TX; Dryopteris filix-mas+TX; Equisetum arvense+TX; Fortune Aza+TX; Fungastop+TX; Heads Up (Chenopodium quinoa saponin extract)+TX; PROBLAD (naturally occurring Blad polypeptide from Lupin seeds), Certis EU+TX; FRACTURE (naturally occurring Blad polypeptide from Lupin seeds), FMC+TX; Pyrethrum/Pyrethrins+TX; Quassia amara+TX; Quercus+TX; Quillaja extract (QL AGRI 35 from BASF)+TX; Reynoutria sachalinensis extract (REGALLIA/REGALIA MAXX from Marrone Bio)+TX; Requiem? Insecticide+TX; Rotenone+TX; ryania/ryanodine+TX; Symphytum officinale+TX; Tanacetum vulgare+TX; Thymol+TX; Thymol mixed with Geraniol (CEDROZ from Eden Research)+TX; Thymol mixed with Geraniol and Eugenol (MEVALONE from Eden Research)+TX; Triact 70+TX; TriCon+TX; Tropaeulum majus+TX; Melaleuca alternifolia extract (TIMOREX GOLD from STK)+TX; Urtica dioica+TX; Veratrin+TX; and Viscum album+TX; and [0555] a safener, such as benoxacor+TX, cloquintocet (including cloquintocet-mexyl)+TX, cyprosulfamide+TX, dichlormid+TX, fenchlorazole (including fenchlorazole-ethyl)+TX, fenclorim+TX, fluxofenim+TX, furilazole+TX, isoxadifen (including isoxadifen-ethyl)+TX, mefenpyr (including mefenpyr-diethyl)+TX, metcamifen+TX and oxabetrinil+TX.

[0556] The references in brackets behind the active ingredients, e.g. [3878-19-1] refer to the Chemical Abstracts Registry number. The above described mixing partners are known. Where the active ingredients are included in The Pesticide Manual [The Pesticide ManualA World Compendium; Thirteenth Edition; Editor: C. D. S. TomLin; The British Crop Protection Council], they are described therein under the entry number given in round brackets hereinabove for the particular compound; for example, the compound abamectin is described under entry number (1). Where [CCN] is added hereinabove to the particular compound, the compound in question is included in the Compendium of Pesticide Common Names, which is accessible on the internet [A. Wood; Compendium of Pesticide Common Names, Copyright ? 1995-2004]; for example, the compound acetoprole is described under the internet address http://www.alanwood.net/pesticides/acetoprole.html.

[0557] Most of the active ingredients described above are referred to hereinabove by a so-called common name, the relevant ISO common name or another common name being used in individual cases. If the designation is not a common name, the nature of the designation used instead is given in round brackets for the particular compound; in that case, the IUPAC name, the IUPAC/Chemical Abstracts name, a chemical name, a traditional name, a compound name or a development code is used or, if neither one of those designations nor a common name is used, an alternative name is employed. CAS Reg. No means the Chemical Abstracts Registry Number.

[0558] The active ingredient mixture of the compounds of formula (I) selected from the compounds defined in the Tables 1 to 57 and Tables P1 to P2 with active ingredients described above comprises a compound selected from one compound defined in the Tables 1 to 57 and Tables P1 to P2 and an active ingredient as described above preferably in a mixing ratio of from 100:1 to 1:6000, especially from 50:1 to 1:50, more especially in a ratio of from 20:1 to 1:20, even more especially from 10:1 to 1:10, very especially from 5:1 and 1:5, special preference being given to a ratio of from 2:1 to 1:2, and a ratio of from 4:1 to 2:1 being likewise preferred, above all in a ratio of 1:1, or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. Those mixing ratios are by weight.

[0559] The mixtures as described above can be used in a method for controlling pests, which comprises applying a composition comprising a mixture as described above to the pests or their environment, with the exception of a method for treatment of the human or animal body by surgery or therapy and diagnostic methods practised on the human or animal body.

[0560] The mixtures comprising a compound of formula (I) selected from the compounds defined in the Tables 1 to 57 and Tables P1 to P2 and one or more active ingredients as described above can be applied, for example, in a single ready-mix form, in a combined spray mixture composed from separate formulations of the single active ingredient components, such as a tank-mix, and in a combined use of the single active ingredients when applied in a sequential manner, i.e. one after the other with a reasonably short period, such as a few hours or days. The order of applying the compounds of formula (I) and the active ingredients as described above is not essential for working the present invention.

[0561] The compositions according to the invention can also comprise further solid or liquid auxiliaries, such as stabilizers, for example unepoxidized or epoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya oil), antifoams, for example silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, fertilizers or other active ingredients for achieving specific effects, for example bactericides, fungicides, nematocides, plant activators, molluscicides or herbicides.

[0562] The compositions according to the invention are prepared in a manner known per se, in the absence of auxiliaries for example by grinding, screening and/or compressing a solid active ingredient and in the presence of at least one auxiliary for example by intimately mixing and/or grinding the active ingredient with the auxiliary (auxiliaries). These processes for the preparation of the compositions and the use of the compounds I for the preparation of these compositions are also a subject of the invention.

[0563] The application methods for the compositions, that is the methods of controlling pests of the abovementioned type, such as spraying, atomizing, dusting, brushing on, dressing, scattering or pouringwhich are to be selected to suit the intended aims of the prevailing circumstancesand the use of the compositions for controlling pests of the abovementioned type are other subjects of the invention. Typical rates of concentration are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm, of active ingredient. The rate of application per hectare is generally 1 to 2000 g of active ingredient per hectare, in particular 10 to 1000 g/ha, preferably 10 to 600 g/ha.

[0564] A preferred method of application in the field of crop protection is application to the foliage of the plants (foliar application), it being possible to select frequency and rate of application to match the danger of infestation with the pest in question. Alternatively, the active ingredient can reach the plants via the root system (systemic action), by drenching the locus of the plants with a liquid composition or by incorporating the active ingredient in solid form into the locus of the plants, for example into the soil, for example in the form of granules (soil application). In the case of paddy rice crops, such granules can be metered into the flooded paddy-field.

[0565] The compounds of formula (I) of the invention and compositions thereof are also be suitable for the protection of plant propagation material, for example seeds, such as fruit, tubers or kernels, or nursery plants, against pests of the abovementioned type. The propagation material can be treated with the compound prior to planting, for example seed can be treated prior to sowing. Alternatively, the compound can be applied to seed kernels (coating), either by soaking the kernels in a liquid composition or by applying a layer of a solid composition. It is also possible to apply the compositions when the propagation material is planted to the site of application, for example into the seed furrow during drilling. These treatment methods for plant propagation material and the plant propagation material thus treated are further subjects of the invention. Typical treatment rates would depend on the plant and pest/fungi to be controlled and are generally between 1 to 200 grams per 100 kg of seeds, preferably between 5 to 150 grams per 100 kg of seeds, such as between 10 to 100 grams per 100 kg of seeds.

[0566] The term seed embraces seeds and plant propagules of all kinds including but not limited to true seeds, seed pieces, suckers, corns, bulbs, fruit, tubers, grains, rhizomes, cuttings, cut shoots and the like and means in a preferred embodiment true seeds.

[0567] The present invention also comprises seeds coated or treated with or containing a compound of formula I. The term coated or treated with and/or containing generally signifies that the active ingredient is for the most part on the surface of the seed at the time of application, although a greater or lesser part of the ingredient may penetrate into the seed material, depending on the method of application. When the said seed product is (re)planted, it may absorb the active ingredient. In an embodiment, the present invention makes available a plant propagation material adhered thereto with a compound of formula I. Further, it is hereby made available, a composition comprising a plant propagation material treated with a compound of formula I.

[0568] Seed treatment comprises all suitable seed treatment techniques known in the art, such as seed dressing, seed coating, seed dusting, seed soaking and seed pelleting. The seed treatment application of the compound formula (I) can be carried out by any known methods, such as spraying or by dusting the seeds before sowing or during the sowing/planting of the seeds.

[0569] The compounds of the invention can be distinguished from other similar compounds by virtue of greater efficacy at low application rates and/or different pest control, which can be verified by the person skilled in the art using the experimental procedures, using lower concentrations if necessary, for example 10 ppm, 5 ppm, 2 ppm, 1 ppm or 0.2 ppm; or lower application rates, such as 300, 200 or 100, mg of Al per m.sup.2. The greater efficacy can be observed by an increased safety profile (against non-target organisms above and below ground (such as fish, birds and bees), improved physico-chemical properties, or increased biodegradability).

[0570] In each aspect and embodiment of the invention, consisting essentially and inflections thereof are a preferred embodiment of comprising and its inflections, and consisting of and inflections thereof are a preferred embodiment of consisting essentially of and its inflections.

[0571] The disclosure in the present application makes available each and every combination of embodiments disclosed herein.

BIOLOGICAL EXAMPLES

[0572] The Examples which follow serve to illustrate the invention. Certain compounds of the invention can be distinguished from known compounds by virtue of greater efficacy at low application rates, which can be verified by the person skilled in the art using the experimental procedures outlined in the Examples, using lower application rates if necessary, for example 50 ppm, 24 ppm, 12.5 ppm, 6 ppm, 3 ppm, 1.5 ppm, 0.8 ppm or 0.2 ppm.

Example B1: Tetranychus Urticae (Two-Spotted Spider Mite): Feeding/Contact Activity

[0573] Bean leaf discs on agar in 24-well microtiter plates were sprayed with aqueous test solutions prepared from 10'000 ppm DMSO stock solutions. After drying the leaf discs were infested with a mite population of mixed ages. The samples were assessed for mortality on mixed population (mobile stages) 8 days after infestation.

[0574] The following compounds resulted in at least 80% mortality at an application rate of 200 ppm: P1.1, P1.2, P1.3, P1.4, P1.5, P1.6, P1.7, P1.8, P.1.9, P1.10, P1.12, P1.13, P1.14, P1.15, P1.18, P1.19, P1.20, P1.21, P1.22, P1.23, P1.24, P1.25, P1.26, P1.27, P1.28, P1.29, P1.30, P1.32, P1.33, P1.35, P1.36, P1.37, P1.38, P1.43, P1.44, P1.45, P1.46, P1.47, P1.48, P1.49, P1.51, P1.52, P1.54, P1.56, P1.60, P1.61, P1.62, P1.63, P1.64, P1.65, P1.66, P1.67, P1.68, P1.69, P1.70, P1.71, P1.72, P1.73, P1.74, P1.75, P1.76, P1.77, P1.78, P1.80, P1.83, P1.84, P1.85, P1.86, P1.89, P1.90, P1.91, P1.92, P1.93, P1.94, P1.95, P1.97, P1.98, P1.100, P1.101, P1.102, P1.103, P1.104, P1.105, P1.106, P1.107, P1.108, P1.109, P1.110, P1.111, P1.112, P1.113, P1.114, P1.115, P1.116, P1.117, P1.118, P1.119, P1.120, P1.122, P1.123, P1.124, P1.125, P1.126, P1.127, P1.128, P1.129, P1.130, P1.131, P1.132, P1.133, P1.134, P1.135, P1.136, P1.137, P1.138, P1.139, P1.141, P1.142, P1.143, P1.144, P1.145, P1.146, P1.147, P1.148, P1.149, P1.150, P1.151, P1.152, P1.153, P1.154, P1.155, P1.156, P1.157, P1.158, P1.159, P1.160, P1.161, P1.162, P1.163, P1.164, P1.165, P1.166, P1.167, P2.1, P2.2, P2.3, P2.4, P2.5, P2.6, P2.7, P2.8, P2.9, P2.10, P2.11, P2.12, P2.13, P2.15, P2.16, P2.17, P2.18, P2.19, P2.20, P2.21, P2.22, P2.23, P2.24, P2.26, P2.27, P2.32, P2.33, P2.35, P2.37, P2.38, P2.39, P2.40, P2.41, P2.42, P2.43, P2.44, P2.45, P2.46, P2.51, P2.54, P2.55.