Intrasacular Aneurysm Occlusion Device with Nested Structures
20230035074 · 2023-02-02
Assignee
Inventors
Cpc classification
A61B17/12177
HUMAN NECESSITIES
A61B17/12181
HUMAN NECESSITIES
International classification
Abstract
This invention is an intrasacular aneurysm occlusion device with nested structures, including an inner embolic structure (e.g. inner mesh, net, braid, and/or stent) which is nested inside an outer embolic structure (e.g. outer mesh, net, braid, and/or stent). The inner embolic structure can have an ellipsoidal, toroidal, inverted jug, or inverted bottle shape. The outer embolic structure can have a spherical shape. The device can also have an opening and valve through which embolic material is inserted into the aneurysm sac.
Claims
1. An intrasacular aneurysm occlusion device with nested structures comprising: a catheter that is configured to be inserted into a blood vessel; a resilient expandable member that is configured to travel through the catheter, be inserted into an aneurysm sac, and then be expanded within the aneurysm sac; and a flexible expandable member that is configured to travel through the catheter, be inserted into the aneurysm sack, and then be expanded within the aneurysm sac, wherein the resilient expandable member is inside the flexible expandable member.
2. The device in claim 1 wherein the resilient expandable member and/or the flexible expandable member is selected from the group consisting of: a mesh, a net, a braid, and a stent.
3. The device in claim 1 which further comprises an opening in the flexible expandable member through which embolic members and/or embolic material is inserted into the aneurysm sac.
4. The device in claim 3 wherein embolic members and/or embolic material comprises embolic coils, hydrogels, microsponges, beads, ribbons, string-of-pearls strands, or congealing material.
5. The device in claim 3 which further comprises a valve in the opening which can be remotely opened or closed by the operator of the device.
6. The device in claim 3 wherein embolic members and/or embolic material fills space between the resilient expandable member and the flexible expandable member, but not space inside the resilient expandable member.
7. An intrasacular aneurysm occlusion device with nested structures comprising: an inner convex mesh which is configured to be radially-expanded within an aneurysm; and an outer convex mesh which is configured to be radially-expanded within the aneurysm, wherein the inner convex mesh is inside the outer convex mesh.
8. The device in claim 7 which further comprises an opening in the outer convex mesh through which embolic members and/or embolic material is inserted into the aneurysm sac.
9. The device in claim 8 wherein embolic members and/or embolic material comprises embolic coils, hydrogels, microsponges, beads, ribbons, string-of-pearls strands, or congealing material.
10. The device in claim 8 which further comprises a valve in the opening which can be remotely opened or closed by the operator of the device.
11. The device in claim 8 wherein embolic members and/or embolic material fills space between the inner convex mesh and the outer convex mesh, but not space inside the inner convex mesh.
12. An intrasacular aneurysm occlusion device with nested structures comprising: an inner embolic structure; and an outer embolic structure, wherein the inner embolic structure is inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
13. The device in claim 12 wherein the inner embolic structure and/or the outer embolic structure is selected from the group consisting of: a mesh, a net, a braid, and a stent.
14. The device in claim 12 which further comprises an opening in the outer embolic structure through which embolic members and/or embolic material is inserted into the aneurysm sac.
15. The device in claim 14 wherein embolic members and/or embolic material comprises embolic coils, hydrogels, microsponges, beads, ribbons, string-of-pearls strands, or congealing material.
16. The device in claim 14 which further comprises a valve in the opening which can be remotely opened or closed by the operator of the device.
17. The device in claim 14 wherein embolic members and/or embolic material fills space between the inner embolic structure and the outer embolic structure, but not space inside the inner embolic structure.
18. The device in claim 12 wherein: the inner embolic structure has an ellipsoidal, toroidal, inverted jug, or inverted bottle shape; and the outer embolic structure has a spherical shape.
19. The device in claim 12 wherein: the inner embolic structure has an inverted jug, inverted bottle, or inverted teardrop shape; and the outer embolic structure has a race-track-oval shape.
20. The device in claim 12 wherein: the inner embolic structure has a spherical, inverted jug, or inverted bottle shape; and the outer embolic structure has a bowl, hemispherical, and/or paraboloidal shape.
Description
BRIEF INTRODUCTION TO THE FIGURES
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DETAILED DESCRIPTION OF THE FIGURES
[0094] In an example, an intrasacular aneurysm occlusion device with nested structures can comprise: a catheter that is configured to be inserted into a blood vessel; a resilient expandable member that is configured to travel through the catheter, be inserted into an aneurysm sac, and then be expanded within the aneurysm sac; and a flexible expandable member that is configured to travel through the catheter, be inserted into the aneurysm sack, and then be expanded within the aneurysm sac, wherein the resilient expandable member is inside the flexible expandable member. In an example, the resilient expandable member and/or the flexible expandable member can be selected from the group consisting of: a mesh, a net, a braid, and a stent. In an example, the device can also have an opening in the flexible expandable member through which embolic members and/or embolic material is inserted into the aneurysm sac. In an example, embolic members and/or embolic material can be embolic coils, hydrogels, microsponges, beads, ribbons, string-of-pearls strands, or congealing material. In an example, the device can also have a valve in the opening which can be remotely opened or closed by the operator of the device. In an example, embolic members and/or embolic material can fill space between the resilient expandable member and the flexible expandable member, but not space inside the resilient expandable member.
[0095] In an example, an intrasacular aneurysm occlusion device with nested structures can comprise: an inner convex mesh which is configured to be radially-expanded within an aneurysm; and an outer convex mesh which is configured to be radially-expanded within the aneurysm, wherein the inner convex mesh is inside the outer convex mesh. In an example, the device can include opening in the outer convex mesh through which embolic members and/or embolic material is inserted into the aneurysm sac. In an example, embolic members and/or embolic material can be embolic coils, hydrogels, microsponges, beads, ribbons, string-of-pearls strands, or congealing material. In an example, the device can include a valve in the opening which can be remotely opened or closed by the operator of the device. In an example, embolic members and/or embolic material can fill space between the inner convex mesh and the outer convex mesh, but not space inside the inner convex mesh.
[0096] In an example, an intrasacular aneurysm occlusion device with nested structures can comprise: an inner embolic structure; and an outer embolic structure, wherein the inner embolic structure is inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an inner embolic structure and/or an outer embolic structure can be selected from the group consisting of: a mesh, a net, a braid, and a stent. In an example, the device can include an opening in the outer embolic structure through which embolic members and/or embolic material is inserted into the aneurysm sac. In an example, embolic members and/or embolic material can be embolic coils, hydrogels, microsponges, beads, ribbons, string-of-pearls strands, or congealing material. In an example, the device can include a valve in the opening which can be remotely opened or closed by the operator of the device. In an example, embolic members and/or embolic material can fill space between the inner embolic structure and the outer embolic structure, but not space inside the inner embolic structure. In an example, an inner embolic structure can have an ellipsoidal, toroidal, inverted jug, or inverted bottle shape; and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have an inverted jug, inverted bottle, or inverted teardrop shape; and an outer embolic structure can have a race-track-oval shape. In an example, an inner embolic structure can have a spherical, inverted jug, or inverted bottle shape; and an outer embolic structure can have a bowl, hemispherical, and/or paraboloidal shape.
[0097]
[0098]
[0099] In an example, the expandable flexible member can be a net or mesh. In an example, the expandable resilient structure can be a stent. In an example, the expandable resilient structure can be substantially spherical or elliptical. In an example, the expandable resilient structure can be expanded before the expandable flexible member is expanded. In an example, the expandable resilient structure and the expandable flexible member can be expanded at substantially the same time. In an example, the total volume of an aneurysm sac can be X cubic units, wherein Y cubic units of the volume of the aneurysm would be filled by the largest-volume sphere that can be fitted into the aneurysm without stretching the aneurysm walls, wherein Z cubic units of the volume of the aneurysm can be filled by the expandable and flexible member; and wherein Z>[Y+0.5(X−Y)]. In an example, the total volume of an aneurysm sac can be X cubic units, wherein Y cubic units of the volume of the aneurysm would be filled by the largest-volume ellipsoid that can be fitted into the aneurysm without stretching the aneurysm walls, wherein Z cubic units of the volume of the aneurysm can be filled by the expandable flexible member; and wherein Z>[Y+0.5(X−Y)].
[0100] We now discuss the specific components of the example shown in
[0101] In an example, expandable resilient structure 103 can be spherical or elliptical. In an example, expandable resilient structure 103 can be an expandable wire mesh or stent. In an example, expandable resilient structure 103 can be radially-expanded in plane which is substantially parallel to the plane that is defined by the central circumference of the aneurysm neck. In an example, resilient structure 103 can be expanded by inflation of a balloon 102 inside resilient structure 103. In an example, balloon 102 can be inflated by a fluid or gas that is delivered via catheter 105 or catheter 106. In an example, resilient structure 103 can self-expand after it exits catheter 105.
[0102] In an example, expandable flexible member 104 can be an expandable flexible net or mesh. In an example, flexible member 104 can be a porous fabric net or mesh. In an example, flexible member 104 can be a porous bag. In an example, expandable flexible member 104 can be a balloon with holes. In an example, flexible member 104 can be expanded by being filled with a plurality of embolic members. In an example, embolic members can be delivered into flexible member 104 through catheter 105 or catheter 106.
[0103] In an example, flexible member 104 can be compressed as it travels through a longitudinal catheter and then be expanded within aneurysm sac 101 after it is released from the catheter. In an example, flexible member 104 can be folded as it travels through a catheter and then be unfolded within aneurysm sac 101. In an example, flexible member 104 can be relatively loose or relaxed (in a lower-energy state) as it travels through a catheter and then be stretched or tense (in a higher-energy state) within aneurysm sac 101. In an example, flexible member 104 can be elastic or stretchable. In an example, flexible member 104 can be sufficiently elastic or stretchable that it expands when filled with an accumulation of embolic members, but not so elastic or stretchable that it allows embolic members to escape.
[0104] In an example, embolic members for filling flexible member 104 can be a plurality of soft, compressible members such as microsponges or blobs of gel. In an example, embolic members can be a plurality of hard, uncompressible members such as hard polymer spheres or beads. In an example, embolic members can be conveyed into flexible member 104 through catheter 105 or catheter 106. In an example, embolic members can be selected from the group consisting of: microsponges, pieces of gel, pieces of foam, beads, and embolic coils. In various examples, embolic members can be conveyed via a liquid flow, a moving belt, a wire loop, or an Archimedes screw.
[0105] In an example, this invention can comprise a method in which resilient structure 103 is expanded first and flexible member 104 is expanded second. In an example, this invention can comprise a method in which flexible member 104 is expanded first and resilient structure 103 is expanded second. In an example, this invention can comprise a method in which flexible member 104 and resilient structure 103 are expanded at substantially the same time.
[0106] As shown in
[0107] In an example, the combination of (a) an outer flexible member 104 that spans substantially the entire perimeter of the aneurysm sac 101 and (b) an inner resilient structure 103 can create a device that is sufficiently flexible to substantially fill the entire volume of an irregularly-shaped aneurysm sac, but also sufficiently resilient so as to compress against the aneurysm walls and not slip out of the aneurysm sac.
[0108] In an example, a flexible expanding member and an arcuate three-dimensional stent can be nested and/or concentric when they are in their second configurations, respectively. In this example, an aneurysm occlusion device has a single flexible expanding member and a single arcuate three-dimensional stent inside the flexible expanding member. In an example, an aneurysm occlusion device can have two nested arcuate three-dimensional stents within a single flexible expanding member. In an example, an aneurysm occlusion device can have two nested flexible expanding members around a single arcuate three-dimensional stent. In an example with two flexible expanding members, an outer flexible expanding member can have a first level of flexibility and an inner flexible expanding member can have a second level of flexibility, wherein the first level is greater than the second level. In this example, a flexible expanding member is filled and expanded by insertion of a plurality of embolic members.
[0109] In an example, an intrasacular aneurysm occlusion device can comprise: (a) a longitudinal catheter that is configured to be inserted into a blood vessel, wherein this blood vessel is the parent vessel from which an aneurysm has formed; (b) a flexible sac-filling portion of the device, wherein this flexible sac-filling portion is configured to travel through the longitudinal catheter and to be inserted into the aneurysm sac; and wherein this flexible sac-filling portion is sufficiently flexible to substantially conform to the walls of an irregularly-shaped aneurysm sac after the flexible sac-filling portion has been expanded; and (c) a resilient wider-than-neck portion of this device, wherein this resilient wider-than-neck portion of this device is configured to travel through the longitudinal catheter and to be inserted into the aneurysm sac; wherein this resilient wider-than-neck portion is expanded inside the flexible sac-filling portion; and wherein this resilient wider-than-neck portion resists compression after it has been expanded.
[0110] In an example, an intrasacular aneurysm occlusion device can comprise: (a) a longitudinal catheter that is configured to be inserted into a blood vessel; (b) a resilient expandable member that is configured to travel through the longitudinal catheter, be inserted into an aneurysm sack, and then be expanded within the aneurysm sack; and wherein this resilient expandable member resists contraction after it has been expanded; and (c) a flexible expandable member that is configured to travel through the longitudinal catheter, be inserted into the aneurysm sack, and then be expanded within the aneurysm sack; wherein the resilient expandable member is inside the flexible expandable member; wherein the resilient expandable member is expanded before or while the flexible expandable member is expanded; and wherein the flexible expandable member is sufficiently flexible to substantively conform to the contours of the walls of the aneurysm sack when the flexible expandable member is expanded within the aneurysm. In an example, the shape of the resilient expandable member can be selected from the group consisting of: apple shape; bowl shape; compressed-sphere shape; cylinder; disk; doughnut shape; egg shape; ellipsoid; Frisbee™ shape; frustum; hour-glass shape; oval; peanut shape; pear shape; pumpkin shape; ring shape; Saturn shape; sphere; tire shape; and torus.
[0111] In an example, an intrasacular aneurysm occlusion device can comprise: a resilient wider-than-neck portion with a first configuration as it is transported to an aneurysm sac and a second configuration after it has been expanded within the aneurysm sac; wherein the resilient wider-than-neck portion in its second configuration has a width which is larger than the diameter of the neck of the aneurysm sac; and wherein the resilient wider-than-neck in its second configuration has a first level of flexibility, elasticity, and/or malleability; and a flexible sac-filling portion with a first configuration as it is being transported to an aneurysm sac and a second configuration after it has been expanded within the aneurysm sac; wherein the flexible sac-filling portion is expanded from its first configuration to its second configuration by the insertion of embolic members into the flexible sac-filling portion; and wherein the flexible sac-filling portion in its second configuration has a second level of flexibility, elasticity, and/or malleability which is greater than the first level of flexibility, elasticity, and/or malleability. Other example variations discussed elsewhere in this disclosure or priority-linked disclosures can also be applied to this example where relevant.
[0112]
[0113] In an example, an inner convex mesh can be spherical. In an example, an inner convex mesh can be ellipsoidal. In an example, an inner convex mesh can be apple, barrel, or pear shaped. In an example, an inner convex mesh can be toroidal. In an example, an inner convex mesh can be hyperboloidal, dumbbell, peanut, or hour-glass shaped. In an example, an inner convex mesh can be disk shaped. In an example, an inner convex mesh can be shaped like a paper lantern. In an example, an inner convex mesh can be a wire mesh and/or frame. In an example, an inner convex mesh can be a woven or braided wire mesh and/or frame. In an example, an inner convex mesh can be made from metal and polymer components. In an example, an outer convex mesh (or net) can be spherical. In an example, an outer convex mesh can be ellipsoidal. In an example, an outer convex mesh can be apple, barrel, or pear shaped. In an example, an outer convex mesh can be shaped like a paper lantern. In an example, an outer convex mesh can be a wire mesh and/or frame. In an example, an outer convex mesh can be a woven or braided wire mesh and/or frame.
[0114] In an example, an outer convex mesh (or net) can be made from metal and polymer components. In an example, an inner convex mesh can be made from a metal and an outer convex mesh can be made from a polymer. In an example, inner and outer convex meshes can be nested. In an example, inner and outer convex meshes can be concentric. In an example, inner and outer convex meshes can be attached to each other. In an example, the proximal ends of inner and outer convex meshes can be attached to each other. In an example, the distal ends of inner and outer convex meshes can be attached to each other. In an example: the proximal ends of inner and outer convex meshes can be attached to each other; and the distal ends of inner and outer convex meshes can be attached to each other.
[0115] In an example, inner and outer convex meshes can both have the same durometer level. In an example, inner and outer convex meshes can both have the same elasticity. In an example, inner and outer convex meshes can both have the same porosity. In an example, an outer convex mesh (or net) can be less elastic than an inner convex mesh. In an example, an outer convex mesh can have a greater durometer level than an inner convex mesh. In an example, an outer convex mesh can have greater porosity than an inner convex mesh. In an example, an outer convex mesh can be more elastic than an inner convex mesh. In an example, an outer convex mesh can have a lower durometer level an inner convex mesh. In an example, an outer convex mesh can have lower porosity than an inner convex mesh.
[0116] In an example, a valve in an outer convex mesh (or net) can be off-center. In an example, a valve in an outer convex mesh (or net) can be offset from the central longitudinal axis of the mesh. In an example, there can be two or more off-center valves through a outer convex mesh. Alternatively, a valve in an outer convex mesh can be central to the cross-section of an outer convex mesh. In an example, a valve in an outer convex mesh can on the central longitudinal axis of the mesh. In an example, the cross-sectional area of a valve can be between 5% to 15% of the maximum cross-sectional area of an outer convex mesh. In an example, the cross-sectional area of a valve can be between 10% to 30% of the maximum cross-sectional area of an outer convex mesh. In an example, a valve can be a leaflet valve. In an example, a valve can be a bi-leaflet valve or tri-leaflet valve, analogous to a heart valve.
[0117] In an example, a valve can passively open when an embolic member is pushed through it and can passively close after the member passes through or when a portion of the member is detached. In an example, such a valve allows an embolic member to be inserted into an aneurysm, but the valve closes to reduce blood flow into the aneurysm after the embolic member has passed through the valve. In an example, an active valve can be remotely opened and/or closed by the operator of the device. In an example, an active valve can be remotely opened and/or closed by an operator by the application of electromagnetic energy. In an example, an active valve can be remotely opened and/or closed by an operator by pulling a filament. In an example, an active valve can be remotely opened and/or closed by an operator by pushing, pulling, or rotating a wire. In an example, an active valve can be remotely opened and/or closed by an operator by cutting, pulling, or pushing a flap or plug.
[0118] In an example, an outer convex mesh (or net) can be made from metal and polymer components. In an example, an inner convex mesh can be made from a metal and an outer convex mesh can be made from a polymer. In an example, inner and outer convex meshes can be nested. In an example, inner and outer convex meshes can be concentric. In an example, inner and outer convex meshes can be attached to each other. In an example, the proximal ends of inner and outer convex meshes can be attached to each other. In an example, the distal ends of inner and outer convex meshes can be attached to each other. In an example: the proximal ends of inner and outer convex meshes can be attached to each other; and the distal ends of inner and outer convex meshes can be attached to each other.
[0119] In an example, inner and outer convex meshes can both have the same durometer level. In an example, inner and outer convex meshes can both have the same elasticity. In an example, inner and outer convex meshes can both have the same porosity. In an example, an outer convex mesh (or net) can be less elastic than an inner convex mesh. In an example, an outer convex mesh can have a greater durometer level than an inner convex mesh. In an example, an outer convex mesh can have greater porosity than an inner convex mesh. In an example, an outer convex mesh can be more elastic than an inner convex mesh. In an example, an outer convex mesh can have a lower durometer level an inner convex mesh. In an example, an outer convex mesh can have lower porosity than an inner convex mesh.
[0120] In an example, a valve in an outer convex mesh (or net) can be off-center. In an example, a valve in an outer convex mesh (or net) can be offset from the central longitudinal axis of the mesh. In an example, there can be two or more off-center valves through a outer convex mesh. Alternatively, a valve in an outer convex mesh can be central to the cross-section of an outer convex mesh. In an example, a valve in an outer convex mesh can on the central longitudinal axis of the mesh. In an example, the cross-sectional area of a valve can be between 5% to 15% of the maximum cross-sectional area of an outer convex mesh. In an example, the cross-sectional area of a valve can be between 10% to 30% of the maximum cross-sectional area of an outer convex mesh. In an example, a valve can be a leaflet valve. In an example, a valve can be a bi-leaflet valve or tri-leaflet valve, analogous to a heart valve.
[0121] In an example, a valve can passively open when an embolic member is pushed through it and can passively close after the member passes through or when a portion of the member is detached. In an example, such a valve allows an embolic member to be inserted into an aneurysm, but the valve closes to reduce blood flow into the aneurysm after the embolic member has passed through the valve. In an example, an active valve can be remotely opened and/or closed by the operator of the device. In an example, an active valve can be remotely opened and/or closed by an operator by the application of electromagnetic energy. In an example, an active valve can be remotely opened and/or closed by an operator by pulling a filament. In an example, an active valve can be remotely opened and/or closed by an operator by pushing, pulling, or rotating a wire. In an example, an active valve can be remotely opened and/or closed by an operator by cutting, pulling, or pushing a flap or plug. Other example variations discussed elsewhere in this disclosure or priority-linked disclosures can also be applied to this example where relevant.
[0122]
[0123] In an example, the inner embolic structure and the outer embolic structure can be nested, with the inner embolic structure inside the hollow interior of the outer embolic structure. In an example, the inner embolic structure and the outer embolic structure can be concentric. In an example, the inner embolic structure and the outer embolic structure can be coaxial (e.g. sharing a common longitudinal axis).
[0124] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) and an outer embolic structure (e.g. outer mesh, net, or stent) can be created as separate structures and then attached and/or connected to each other. In an example, the proximal (e.g. closer to an aneurysm neck) surface of an inner embolic structure can be attached to the proximal interior surface of the outer embolic structure. In an example, the distal (e.g. farther from an aneurysm neck) surface of an inner embolic structure can be attached to the distal interior surface of the outer embolic structure. In an example, the proximal (e.g. closer to an aneurysm neck) and distal (e.g. farther from the aneurysm neck) surfaces of an inner embolic structure can be attached to the proximal and distal interior surfaces, respectively, of the outer embolic structure.
[0125] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) and an outer embolic structure (e.g. outer mesh, net, or stent) can be created as parts (e.g. portions, sections, undulations, bulbs, or loops) of the same continuous structure. In an example, an inner embolic structure and an outer embolic structure can be parts of the same mesh or net. In an example, an inner embolic structure and an outer embolic structure can be parts or sections of a radially-constrained tubular mesh or net. In an example, an inner embolic structure and an outer embolic structure can be parts or sections of a tubular mesh or net which is radially-constrained at multiple locations (e.g. at both ends and at least once in a mid-section). In an example, an inner embolic structure and an outer embolic structure can be parts or sections of a tubular structure which has been radially constrained at its ends. In an example, an inner embolic structure and an outer embolic structure can be parts or sections of a tubular structure which has been radially constrained at its middle and ends.
[0126] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can be connected to an outer embolic structure (e.g. outer mesh, net, or stent) by a toroidal ring or cylindrical band. In an example, an inner embolic structure (e.g. inner mesh, net, or stent) and an outer embolic structure (e.g. outer mesh, net, or stent) can be formed from a common continuous braided structure by a radially-constraining toroidal ring or cylindrical band. In an example, an inner embolic structure can be connected to an outer embolic structure by two toroidal rings or cylindrical bands, one inside the connection and one outside the connection.
[0127] In an example, another type of embolic members and/or material (e.g. coils, “string of pearls” embolic components, hydrogel particles, or a congealing substance) can be inserted into the interior of the inner embolic structure through the toroidal ring or cylindrical band. In an example, another type of embolic members and/or material (e.g. coils, “string of pearls” embolic components, hydrogel particles, or a congealing substance) can be inserted into the space between the inner embolic structure and the outer embolic structure through the toroidal ring or cylindrical band. In an example, another type of embolic members and/or material (e.g. coils, “string of pearls” embolic components, hydrogel particles, or a congealing substance) can be inserted into the both the interiors of inner embolic structure and the outer embolic structure through the toroidal ring or cylindrical band.
[0128] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can be attached and/or connected to an outer embolic structure (e.g. outer mesh, net, or stent) at one location and/or surface. In an example, an inner embolic structure can be attached and/or connected to an outer embolic structure at one central proximal location and/or surface, wherein proximal means closer to the neck of an aneurysm when the device is deployed in an aneurysm sac. In an example, an inner embolic structure can be attached and/or connected to an outer embolic structure at one central distal location and/or surface, wherein proximal means closer to the neck of an aneurysm when the device is deployed in an aneurysm sac.
[0129] In an example, an inner embolic structure can be attached and/or connected to an outer embolic structure at its most proximal location and/or surface, wherein proximal means closer to the neck of an aneurysm when the device is deployed in an aneurysm sac. In an example, an inner embolic structure can be attached and/or connected to an outer embolic structure at its most distal location and/or surface, wherein distal means farther from the neck of an aneurysm when the device is deployed in an aneurysm sac. In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can be attached and/or connected to an outer embolic structure (e.g. outer mesh, net, or stent) at two location and/or surfaces: at its most proximal location and/or surface; and at its most distal location and/or surface.
[0130] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can have a spherical shape, ellipsoidal shape, oblate spheroid shape, racetrack ovaloid shape, and/or egg shape. In an example, an inner embolic structure can have a hemispherical shape, bowl shape, concave, and/or convex shape. In an example, an inner embolic structure can have a toroidal shape, doughnut shape, ring shape, cylindrical shape, and/or disk shape. In an example, an inner embolic structure can have an hour-glass shape, hyperboloidal shape, peanut shape, mushroom shape, dumbbell shape, and/or undulating shape. In an example, an inner embolic structure can have an apple shape, barrel shape, half-canister shape, pumpkin shape, pear shape, teardrop shape, tree ornament (revolved sine-wave), jug or bottle shape, cardioid shape, beehive, 3D revolved horse-shoe shape, paper lantern shape (e.g. pleated cylindrical shape), accordion shape (e.g. Weerdahl), and/or Saturn shape (e.g. spherical with one or more rings). In an example, an inner embolic structure can have a geodesic shape and/or frustal shape.
[0131] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) and an outer embolic structure (e.g. outer mesh, net, or stent) can both have the same shape. In an example, an inner embolic structure and an outer embolic structure can have different shapes. In an example, an inner embolic structure and an outer embolic structure can have shapes with the same proximal-to-distal orientation. In an example, an inner embolic structure and an outer embolic structure can have shapes with different orientations. In an example, the shape of an inner embolic structure can be inverted from a proximal-to-distal orientation to a distal-to-proximal orientation. In an example, the shape of an outer embolic structure can be inverted from a proximal-to-distal orientation to a distal-to-proximal orientation.
[0132] In an example, an outer embolic structure can have a spherical shape, ellipsoidal shape, oblate spheroid shape, racetrack ovaloid shape, and/or egg shape. In an example, an outer embolic structure can have a hemispherical shape, bowl shape, concave, and/or convex shape. In an example, an outer embolic structure can have a toroidal shape, doughnut shape, ring shape, cylindrical shape, and/or disk shape. In an example, an outer embolic structure can have an hour-glass shape, hyperboloidal shape, peanut shape, mushroom shape, dumbbell shape, and/or undulating shape. In an example, an outer embolic structure can have an apple shape, barrel shape, half-canister shape, pumpkin shape, pear shape, teardrop shape, tree ornament (revolved sine-wave) (e.g. Christmas tree ornament) shape jug or bottle shape, cardioid shape, beehive, 3D revolved horse-shoe shape, paper lantern shape (e.g. pleated cylindrical shape), accordion shape (e.g. Weerdahl), and/or Saturn shape (e.g. spherical with one or more rings). In an example, an outer embolic structure can have a geodesic shape and/or frustal shape.
[0133] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can have a spherical shape and an outer embolic structure (e.g. outer mesh, net, or stent) can also have a spherical shape. In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have an ellipsoidal shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have a toroidal shape. In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have a peanut shape. In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have an hour-glass shape. In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have an hour-glass shape. In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have an ellipsoidal shape.
[0134] In an example, an inner embolic structure can have a cardioid shape and an outer embolic structure can have a half-canister shape. In an example, an inner embolic structure can have a tree ornament (revolved sine-wave) shape and an outer embolic structure can have a tree ornament (revolved sine-wave) shape. In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have an ellipsoidal shape. In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have a toroidal shape. In an example, an inner embolic structure can have a half-canister shape and an outer embolic structure can have an inverted half-barrel shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have a jug or bottle shape and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have a spherical shape.
[0135] In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have a toroidal shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have an hour-glass shape. In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have an ellipsoidal shape.
[0136] In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have a peanut shape. In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have a peanut shape. In an example, an inner embolic structure can have a pumpkin shape and an outer embolic structure can have a pumpkin shape. In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have an ellipsoidal shape. In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have a hemispherical shape.
[0137] In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have a jug or bottle and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have a teardrop shape and an outer embolic structure can have a barrel shape. In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have a toroidal shape.
[0138] In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have a peanut shape. In an example, an inner embolic structure can have a cardioid shape and an outer embolic structure can have an egg or ovaloid shape. In an example, an inner embolic structure can have a racetrack ovaloid shape and an outer embolic structure can have a half-canister shape. In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have a peanut shape.
[0139] In an example, an inner embolic structure can have a cardioid shape and an outer embolic structure can have a pumpkin shape. In an example, an inner embolic structure can have a racetrack ovaloid shape and an outer embolic structure can have a half-canister shape. In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have a toroidal shape. In an example, an inner embolic structure can have a barrel shape and an outer embolic structure can have a barrel shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have an ellipsoidal shape. In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have an hour-glass shape.
[0140] In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have a toroidal shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have an ellipsoidal shape. In an example, an inner embolic structure can have a cardioid shape and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have a hemispherical shape.
[0141] In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have a toroidal shape. In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have a peanut shape. In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have an ellipsoidal shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have a toroidal shape.
[0142] In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have a jug or bottle shape and an outer embolic structure can have a barrel shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have a peanut shape. In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have a spherical shape and an outer embolic structure can have a carlavian curve shape. In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have a peanut shape.
[0143] In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have an hour-glass shape. In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have a jug or bottle shape and an outer embolic structure can have a racetrack ovaloid shape. In an example, an inner embolic structure can have a teardrop shape and an outer embolic structure can have a pear shape.
[0144] In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have an hour-glass shape. In an example, an inner embolic structure can have a jug or bottle shape and an outer embolic structure can have an racetrack ovaloid shape. In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have a spherical shape.
[0145] In an example, an inner embolic structure can have an apple shape and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have a peanut shape and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have a toroidal shape and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have a hemispherical shape and an outer embolic structure can have an hour-glass shape.
[0146] In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have a spherical shape. In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have a bowl shape. In an example, an inner embolic structure can have an hour-glass shape and an outer embolic structure can have an apple shape. In an example, an inner embolic structure can have a bowl shape and an outer embolic structure can have a hemispherical shape. In an example, an inner embolic structure can have an ellipsoidal shape and an outer embolic structure can have an hour-glass shape.
[0147] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can be folded or pleated. In an example, an inner embolic structure can have multiple folds or pleats. In an example, an inner embolic structure can have two or three folds or pleats. In an example, an inner embolic structure can have four or more folds or pleats. In an example, an inner embolic structure can have one or more proximal-to-distal (e.g. longitudinal) folds or pleats. In an example, an inner embolic structure can have one or more lateral folds or pleats. In an example, an inner embolic structure can have one or more circumferential folds or pleats. In an example, an inner embolic structure can be folded or pleated before it is expanded inside an aneurysm sac.
[0148] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can have lobes or undulations. In an example, an inner embolic structure can have multiple lobes or undulations. In an example, an inner embolic structure can have two or three lobes or undulations. In an example, an inner embolic structure can have four or more lobes or undulations. In an example, an inner embolic structure can have one or more proximal-to-distal (e.g. longitudinal) lobes or undulations. In an example, an inner embolic structure can have one or more lateral lobes or undulations. In an example, an inner embolic structure can have one or more circumferential lobes or undulations. In an example, an inner embolic structure can be lobed or undulating before it is expanded inside an aneurysm sac.
[0149] In an example, an outer embolic structure (e.g. outer mesh, net, or stent) can be folded or pleated. In an example, an outer embolic structure can have multiple folds or pleats. In an example, an outer embolic structure can have two or three folds or pleats. In an example, an outer embolic structure can have four or more folds or pleats. In an example, an outer embolic structure can have one or more proximal-to-distal (e.g. longitudinal) folds or pleats. In an example, an outer embolic structure can have one or more lateral folds or pleats. In an example, an outer embolic structure can have one or more circumferential folds or pleats. In an example, an outer embolic structure can be folded or pleated before it is expanded inside an aneurysm sac.
[0150] In an example, an outer embolic structure (e.g. outer mesh, net, or stent) can have lobes or undulations. In an example, an outer embolic structure can have multiple lobes or undulations. In an example, an outer embolic structure can have two or three lobes or undulations. In an example, an outer embolic structure can have four or more lobes or undulations. In an example, an outer embolic structure can have one or more proximal-to-distal (e.g. longitudinal) lobes or undulations. In an example, an outer embolic structure can have one or more lateral lobes or undulations. In an example, an outer embolic structure can have one or more circumferential lobes or undulations. In an example, an outer embolic structure can be lobed or undulating before it is expanded inside an aneurysm sac.
[0151] In an example, an intrasacular embolic structure (e.g. an inner structure and/or an outer structure) can have a shape selected from the group consisting of: spherical shape, ellipsoidal shape, oblate spheroid shape, barrel shape, canister shape, racetrack ovaloid shape, disk shape, apple shape, pumpkin shape, toroidal shape, doughnut shape, tree ornament (3D revolved sine-wave), egg shape, pear shape, teardrop shape, cardioid shape, bullet shape, hemispherical shape, bowl shape, half-canister shape, funnel shape, jellyfish shape, 3D revolved horse-shoe shape, jug or bottle shape, mushroom shape, hour-glass shape, hyperboloidal shape, peanut shape, dumbbell shape, reflected mushroom shape, Saturn shape, paper lantern shape, and geodesic shape.
[0152] In an example, there can be an opening an inner embolic structure (e.g. inner mesh, net, or stent) through which another type of embolic members and/or material (e.g. coils, “string of pearls” embolic components, congealing embolic material) can be inserted into the inner embolic structure. In an example, this opening can be centrally-located on the proximal surface of the inner embolic structure. In an example, this opening can be centrally-located on the aneurysm-neck-facing surface of the inner embolic structure. In an example, this opening can be the interior of a cylindrical band or tube which extends into the interior of the inner embolic structure.
[0153] In an example, an opening an inner embolic structure can be closed remotely by the operator of the device after embolic material has been inserted into the inner embolic structure. In an example, this opening can be closed remotely by the operator of the device by a closure mechanism selected from the group consisting of: activating a MEMS actuator, closing a leaflet valve, heating the opening, inserting a plug into the opening, melting the opening, operating an electromagnetic actuator, pulling a thread, suture, or string, pulling a wire, pulling catheter, pushing a wire, removing a strut which spans the opening, rotating a catheter, rotating a wire, shifting two layers the device relative to each other, tightening a loop around the opening, and transmitting electromagnetic energy.
[0154] In an example, there can be a lumen (through a tube, catheter, or cylindrical mesh) through the central proximal-to-distal axis of an inner embolic structure (e.g. inner mesh, net, or stent) through which another type of embolic members and/or material (e.g. coils, “string of pearls” embolic components, congealing embolic material) can be inserted into the space between the inner embolic structure and the outer embolic structure. In an example, there can be a lumen (through a tube, catheter, or cylindrical mesh) through the central proximal-to-distal axis of an inner embolic structure (e.g. inner mesh, net, or stent) through which another type of embolic members and/or material (e.g. coils, “string of pearls” embolic components, congealing embolic material) can be inserted into the space between the outer embolic structure and the walls of the aneurysm sac. In an example, this lumen can have a hyperboloidal and/or funnel shape.
[0155] In an example, an inner embolic structure can be connected to an outer embolic structure by two coaxial bands (e.g. rings, bands, tubes, and/or cylinders) comprising an inner band and outer band, wherein the inner and outer embolic structures are between the inner and outer bands. In an example, an inner embolic structure can be connected to an outer embolic structure by two coaxial bands (e.g. rings, bands, tubes, and/or cylinders) comprising an inner band and outer band, wherein the inner and outer embolic structures pass through the space between the inner and outer bands. In an example, an inner embolic structure and an outer embolic structure are radially-constrained by two coaxial bands (e.g. rings, bands, tubes, and/or cylinders) comprising an inner band and outer band, wherein the inner and outer embolic structures pass through the space between the inner and outer bands.
[0156] In an example, an inner embolic structure can be connected to an outer embolic structure by two coaxial bands (e.g. rings, bands, tubes, and/or cylinders) comprising an inner band and outer band, wherein the inner and outer embolic structures are between the inner and outer bands, and wherein other embolic structures or materials are inserted into the aneurysm sac through the center of the inner band. In an example, an inner embolic structure can be connected to an outer embolic structure by two coaxial bands (e.g. rings, bands, tubes, and/or cylinders) comprising an inner band and outer band, wherein the inner and outer embolic structures pass through the space between the inner and outer bands, and wherein other embolic structures or materials are inserted into the aneurysm sac through the center of the inner band. In an example, an inner embolic structure and an outer embolic structure are radially-constrained by two coaxial bands (e.g. rings, bands, tubes, and/or cylinders) comprising an inner band and outer band, wherein the inner and outer embolic structures pass through the space between the inner and outer bands, and wherein other embolic structures or materials are inserted into the aneurysm sac through the center of the inner band.
[0157] In an example, the size of an inner embolic structure (e.g. inner mesh, net, or stent) can be between 75% and 95% of the size of an outer embolic structure (e.g. outer mesh, net, or stent). In an example, the volume of an inner embolic structure (e.g. inner mesh, net, or stent) can be between 75% and 95% of the interior volume of an outer embolic structure (e.g. outer mesh, net, or stent). In an example, the size of an inner embolic structure can be between 45% and 80% of the size of an outer embolic structure. In an example, the volume of an inner embolic structure can be between 45% and 80% of the interior volume of an outer embolic structure.
[0158] In an example, the size of an inner embolic structure can be between 40% and 60% of the size of an outer embolic structure. In an example, the volume of an inner embolic structure can be between 40% and 60% of the interior volume of an outer embolic structure. In an example, the size of an inner embolic structure can be between 20% and 50% of the size of an outer embolic structure. In an example, the volume of an inner embolic structure can be between 20% and 50% of the interior volume of an outer embolic structure. In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can be within the proximal half of the interior of an outer embolic structure (e.g. outer mesh, net, or stent). In an example, an inner embolic structure (e.g. inner mesh, net, or stent) can be within the proximal third of the interior of an outer embolic structure (e.g. outer mesh, net, or stent).
[0159] In an example, an inner embolic structure (e.g. inner mesh, net, or stent) and an outer embolic structure (e.g. outer mesh, net, or stent) can have different material and/or structural properties. In an example, an inner embolic structure can have a level of durometer which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure (e.g. inner mesh, net, or stent) and an outer embolic structure (e.g. outer mesh, net, or stent) can have different levels of Young's Modulus. In an example, an inner embolic structure can have a level of porosity which is greater than that of that of an outer embolic structure.
[0160] In an example, an inner embolic structure can have a level of malleability which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of bendability which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different levels of elasticity. In an example, an inner embolic structure can have a level of tensile strength which is less than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of durometer which is less than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of elasticity which is less than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of elasticity which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different level of stiffness. In an example, an inner embolic structure can have a level of flexibility which is less than that of that of an outer embolic structure.
[0161] In an example, an inner embolic structure can have a level of flexibility which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of softness which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of softness which is less than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different levels of tensile strength. In an example, an inner embolic structure and an outer embolic structure can have different thicknesses. In an example, an inner embolic structure and an outer embolic structure can have different levels of bendability. In an example, an inner embolic structure can have a level of stiffness which is less than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different levels of flexibility. In an example, an inner embolic structure can have a level of tensile strength which is greater than that of that of an outer embolic structure.
[0162] In an example, an inner embolic structure can have a level of bendability which is less than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different levels of malleability. In an example, an inner embolic structure can have a level of Young's Modulus which is less than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different levels of softness.
[0163] In an example, an inner embolic structure can have a thickness which is less than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of porosity which is less than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different levels of durometer. In an example, an inner embolic structure can have a level of stiffness which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure and an outer embolic structure can have different levels of porosity. In an example, an inner embolic structure can have a level of Young's Modulus which is greater than that of that of an outer embolic structure. In an example, an inner embolic structure can have a level of malleability which is less than that of that of an outer embolic structure. In an example, an inner embolic structure can have a thickness which is greater than that of that of an outer embolic structure.
[0164] In an example, an intrasacular aneurysm occlusion device with inner and outer meshes can be made by the following steps: radially-constraining the proximal end of a tubular mesh; radially-constraining a mid-section of tubular mesh approximately one-third (e.g. between 25% and 45%) of the way from the proximal end to the distal end, thereby dividing the tube into proximal (approximately one-third) and distal (approximately two-thirds) portions; everting the distal portion over the proximal portion; and then radially-constraining the remaining open end of the tube. In an example, an intrasacular aneurysm occlusion device with inner and outer meshes can be made by the following steps: radially-constraining the proximal end of a tubular mesh; radially-constraining a mid-section of tubular mesh approximately one-fourth (e.g. between 20% and 30%) of the way from the proximal end to the distal end, thereby dividing the tube into proximal (approximately one-fourth) and distal (approximately three-fourths) portions; everting the distal portion over the proximal portion; and then radially-constraining the remaining open end of the tube.
[0165] In an example, an intrasacular aneurysm occlusion device with inner and outer meshes can be made by the following steps: radially-constraining the proximal end of a tubular mesh; radially-constraining a mid-section of tubular mesh approximately two-thirds (e.g. between 55% and 75%) of the way from the proximal end to the distal end, thereby dividing the tube into proximal (approximately two-thirds) and distal (approximately one-third) portions; everting the distal portion over the proximal portion; and then radially-constraining the remaining open end of the tube. In an example, an intrasacular aneurysm occlusion device with inner and outer meshes can be made by the following steps: radially-constraining the proximal end of a tubular mesh; radially-constraining a mid-section of tubular mesh approximately three-fourths (e.g. between 65% and 85%) of the way from the proximal end to the distal end, thereby dividing the tube into proximal (approximately three-fourths) and distal (approximately one-fourth) portions; everting the distal portion over the proximal portion; and then radially-constraining the remaining open end of the tube. Other example variations discussed elsewhere in this disclosure or priority-linked disclosures can also be applied to this example where relevant.
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[0199] In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a funnel shape; and an outer embolic structure (e.g. net, mesh, or stent) with a cardioid shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a teardrop shape; and an outer embolic structure (e.g. net, mesh, or stent) with a racetrack ovaloid shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0200] In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a racetrack ovaloid shape; and an outer embolic structure (e.g. net, mesh, or stent) with a canister shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0201] Alternatively, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a pear shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted bowl, hemispherical, and/or paraboloidal shape; and an outer embolic structure (e.g. net, mesh, or stent) with a bowl, hemispherical, and/or paraboloidal shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a toroidal shape; and an outer embolic structure (e.g. net, mesh, or stent) with an ellipsoidal shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0202] In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a bowl, hemispherical, and/or paraboloidal shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted half-canister shape; and an outer embolic structure (e.g. net, mesh, or stent) with a half-canister shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a tree ornament shape; and an outer embolic structure (e.g. net, mesh, or stent) with a canister shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0203] In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted jug and/or bottle shape; and an outer embolic structure (e.g. net, mesh, or stent) with a bowl, hemispherical, and/or paraboloidal shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted jug and/or bottle shape; and an outer embolic structure (e.g. net, mesh, or stent) with an ellipsoidal shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0204] Alternatively, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an ellipsoidal shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0205] In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted jug and/or bottle shape; and an outer embolic structure (e.g. net, mesh, or stent) with a half-canister shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted jug and/or bottle shape; and an outer embolic structure (e.g. net, mesh, or stent) with a racetrack ovaloid shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted jug and/or bottle shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a spherical shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0206] In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a spherical shape; and an outer embolic structure (e.g. net, mesh, or stent) with a bowl, hemispherical, and/or paraboloidal shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. Alternatively, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an apple shape; and an outer embolic structure (e.g. net, mesh, or stent) with an apple shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0207] In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a canister shape; and an outer embolic structure (e.g. net, mesh, or stent) with a canister shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a funnel shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0208] In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a toriodal shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a cardioid shape; and an outer embolic structure (e.g. net, mesh, or stent) with an egg shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a disk shape; and an outer embolic structure (e.g. net, mesh, or stent) with a spherical shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0209] In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a pumpkin shape; and an outer embolic structure (e.g. net, mesh, or stent) with a pumpkin shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In an example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an apple shape; and an outer embolic structure (e.g. net, mesh, or stent) with an egg shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted teardrop shape; and an outer embolic structure (e.g. net, mesh, or stent) with a racetrack ovaloid shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
[0210] Alternatively, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with a cardioid shape; and an outer embolic structure (e.g. net, mesh, or stent) with an ellipsoidal shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac. In another example, an intrasacular aneurysm occlusion device can comprise: an inner embolic structure (e.g. net, mesh, or stent) with an inverted teardrop shape; and an outer embolic structure (e.g. net, mesh, or stent) with a bullet shape, wherein the inner embolic structure is (at least partially) inside the outer embolic structure, and wherein the inner embolic structure and the outer embolic structure are configured to be inserted into and expanded within an aneurysm sac.
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