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Novel 5-substituted imidazole derivatives

20180084780 ยท 2018-03-29

    Inventors

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    Abstract

    The present invention relates to novel 5-substituted imidazolylmethyl derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.

    Claims

    1. Imidazole derivative of the formula (I) ##STR00178## wherein R.sup.1 represents hydrogen, in each case optionally branched C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-haloalkyl, C.sub.2-C.sub.7-alkenyl, C.sub.2-C.sub.7-haloalkenyl, C.sub.2-C.sub.8-alkynyl, C.sub.2-C.sub.8-haloalkynyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted bicycloalkyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.8-cycloalkylalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-halocycloalkyl-C.sub.1-C.sub.4-alkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-halocycloalkyl-C.sub.1-C.sub.4-haloalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl-C.sub.1-C.sub.4-haloalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl-C.sub.3-C.sub.7-cycloalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkenyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.1-C.sub.4-alkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.3-C.sub.7-cycloalkyl; R.sup.2 represents H, C.sub.1-C.sub.8-alkyl, Si(R.sup.3a)(R.sup.3b)(R.sup.3c), P(O)(OH).sub.2, CH.sub.2OP(O)(OH).sub.2, C(O)C.sub.1-C.sub.8-alkyl, C(O)C.sub.3-C.sub.7-cycloalkyl, C(O)NHC.sub.1-C.sub.8-alkyl; C(O)N-di-C.sub.1-C.sub.8-alkyl; C(O)OC.sub.1-C.sub.8-alkyl; wherein the C(O)C.sub.1-C.sub.8-alkyl, C(O)C.sub.3-C.sub.7-cycloalkyl, C(O)NHC.sub.1-C.sub.8-alkyl; C(O)N-di-C.sub.1-C.sub.8-alkyl or C(O)OC.sub.1-C.sub.8-alkyl may be non-substituted or substituted by one or more group(s) selected from halogen or C.sub.1-C.sub.8-alkoxy; wherein R.sup.3a, R.sup.3b, R.sup.3c represent independent from each other a phenyl or C.sub.1-C.sub.8-alkyl; R.sup.3 represents halogen; hydroxyl; cyano; isocyano; nitro; amino; sulfanyl; pentafluoro-.sup.6-sulfanyl; carboxaldehyde, hydroxycarbonyl, C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-haloalkyl; C.sub.1-C.sub.8-cyanoalkyl; C.sub.1-C.sub.8-alkyloxy; C.sub.1-C.sub.8-halogenalkyloxy; tri(C.sub.1-C.sub.8-alkyl)silyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.1-C.sub.8-alkyl; C.sub.3-C.sub.7-cycloalkyl; C.sub.3-C.sub.7-halogencycloalkyl; C.sub.3-C.sub.7-cycloalkenyl; C.sub.3-C.sub.7-halogencycloalkenyl; C.sub.4-C.sub.10-cycloalkylalkyl; C.sub.4-C.sub.10-halocycloalkylalkyl; C.sub.6-C.sub.12-cycloalkylcycloalkyl; C.sub.1-C.sub.8-alkyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.1-C.sub.8-alkoxy-C.sub.3-C.sub.7-cycloalkyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.2-C.sub.8-alkenyl; C.sub.2-C.sub.8-alkynyl; C.sub.2-C.sub.8-alkenyloxy; C.sub.2-C.sub.8-halogenalkenyloxy; C.sub.3-C.sub.8-alkynyloxy; C.sub.3-C.sub.8-halogenoalkynyloxy; C.sub.1-C.sub.8-alkylamino; C.sub.1-C.sub.8-halogenalkylamino; C.sub.1-C.sub.8-cyanoalkoxy; C.sub.4-C.sub.8-cycloalkylalkoxy; C.sub.3-C.sub.6-cycloalkoxy: C.sub.1-C.sub.8-alkylsulfanyl; C.sub.1-C.sub.8-halogenoalkylsulfanyl; C.sub.1-C.sub.8-alkylcarbonyl; C.sub.1-C.sub.8-halogenoalkylcarbonyl; arylcarbonyl; aryl-C.sub.1-C.sub.6-alkylcarbonyl; C.sub.3-C.sub.8-cycloalkylcarbonyl; C.sub.3-C.sub.8-halogenocycloalkylcarbonyl; C.sub.1-C.sub.8-alkylcarbamoyl; di-C.sub.1-C.sub.8-alkylcarbamoyl; NC.sub.1-C.sub.8-alkyloxycarbamoyl; C.sub.1-C.sub.8-alkoxycarbamoyl; NC.sub.1-C.sub.8-alkyl-C.sub.1-C.sub.8-alkoxycarbamoyl; aminothiocarbonyl; C.sub.1-C.sub.8-alkoxycarbonyl; C.sub.1-C.sub.8-halooxycarbonyl; C.sub.1-C.sub.8-halogenoalkoxycarbonyl; C.sub.3-C.sub.8s-cycloalkoxycarbonyl; C.sub.2-C.sub.8-alkoxyalkylcarbonyl; C.sub.2-C.sub.8-halogenoalkoxyalkylcarbonyl; C.sub.3-C.sub.10-cycloalkoxyalkylcarbonyl; C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl; C.sub.3-C.sub.8-cycloalkylaminocarbonyl; C.sub.1-C.sub.8-alkylcarbonyloxy; C.sub.1-C.sub.8-halogenoalkylcarbonyloxy; C.sub.3-C.sub.8-cycloalkylcarbonyloxy: C.sub.1-C.sub.8-alkylcarbonylamino; C.sub.1-C.sub.8-halogenoalkylcarbonylamino; C.sub.1-C.sub.8-alkylaminocarbonyloxy; di-C.sub.1-C.sub.8-alkylaminocarbonyloxy; C.sub.1-C.sub.8-alkyloxycarbonyloxy; C.sub.1-C.sub.8-alkylsulfinyl; C.sub.1-C.sub.8-halogenoalkylsulfinyl; C.sub.1-C.sub.8-alkylsulfonyl; C.sub.1-C.sub.8-halogenoalkylsulfonyl; C.sub.1-C.sub.8-alkylsulfonyloxy; C.sub.1-C.sub.8-halogenoalkylsulfonyloxy; C.sub.1-C.sub.8-alkylaminosulfamoyl; di-C.sub.1-C.sub.8-alkylaminosulfamoyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.8-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; hydroxyimino-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.3-C.sub.7-cycloalkyl; hydroxyimino-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkylimino)-oxy; (C.sub.1-C.sub.8-alkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.7-cycloalkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.6-alkylimino)-oxy-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkenyloxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkynyloxyimino)-C.sub.1-C.sub.8-alkyl; (benzyloxyimino)-C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-alkoxyalkyl; C.sub.1-C.sub.8-alkylthioalkyl; C.sub.1-C.sub.8-alkoxyalkoxyalkyl; C.sub.1-C.sub.8-halogenoalkoxyalkyl; benzyl; phenyl; 5-membered heteroaryl; 6-membered heteroaryl; benzyloxy; phenyloxy; benzylsulfanyl; benzylamino; phenylsulfanyl; or phenylamino; wherein the benzyl; phenyl, 5-membered heteroaryl, 6-membered heteroaryl, benzyloxy or phenyloxy may be optionally substituted by one or more group(s) selected from halogen; hydroxyl; cyano; isocyano; amino; sulfanyl; pentafluoro-.sup.6-sulfanyl; carboxaldehyde, hydroxycarbonyl, C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-haloalkyl; C.sub.1-C.sub.8-cyanoalkyl; C.sub.1-C.sub.8-alkyloxy; C.sub.1-C.sub.8-halogenalkyloxy; tri(C.sub.1-C.sub.8-alkyl)silyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.1-C.sub.8-alkyl; C.sub.3-C.sub.7-cycloalkyl; C.sub.3-C.sub.7-halogencycloalkyl; C.sub.3-C.sub.7-cycloalkenyl; C.sub.3-C.sub.7-halogencycloalkenyl; C.sub.4-C.sub.10-cycloalkylalkyl; C.sub.4-C.sub.10-halocycloalkylalkyl; C.sub.6-C.sub.12-cycloalkylcycloalkyl; C.sub.1-C.sub.8-alkyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.1-C.sub.8-alkoxy-C.sub.3-C.sub.7-cycloalkyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.2-C.sub.8-alkenyl; C.sub.2-C.sub.8-alkynyl; C.sub.2-C.sub.8-alkenyloxy; C.sub.2-C.sub.8-halogenalkenyloxy; C.sub.3-C.sub.8-alkynyloxy; C.sub.3-C.sub.8-halogenoalkynyloxy; C.sub.1-C.sub.8-alkylamino; C.sub.1-C.sub.8-halogenalkylamino; C.sub.1-C.sub.8-cyanoalkoxy; C.sub.4-C.sub.8-cycloalkylalkoxy; C.sub.3-C.sub.6-cycloalkoxy; C.sub.1-C.sub.8-alkylsulfanyl; C.sub.1-C.sub.8-halogenoalkylsulfanyl; C.sub.1-C.sub.8-alkylcarbonyl; C.sub.1-C.sub.8-halogenoalkylcarbonyl; arylcarbonyl; aryl-C.sub.1-C.sub.6-alkylcarbonyl; C.sub.3-C.sub.8-cycloalkylcarbonyl; C.sub.3-C.sub.8-halogenocycloalkylcarbonyl; C.sub.1-C.sub.8-alkylcarbamoyl; di-C.sub.1-C.sub.8-alkylcarbamoyl; NC.sub.1-C.sub.8-alkyloxycarbamoyl; C.sub.1-C.sub.8-alkoxycarbamoyl; NC.sub.1-C.sub.8-alkyl-C.sub.1-C.sub.8-alkoxycarbamoyl; aminothiocarbonyl; C.sub.1-C.sub.8-alkoxycarbonyl; C.sub.1-C.sub.8-halogenoalkoxycarbonyl; C.sub.3-C.sub.8-cycloalkoxycarbonyl; C.sub.2-C.sub.8-alkoxyalkylcarbonyl; C.sub.2-C.sub.8-halogenoalkoxyalkylcarbonyl; C.sub.3-C.sub.10-cycloalkoxyalkylcarbonyl; C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl; C.sub.3-C.sub.8-cycloalkylaminocarbonyl; C.sub.1-C.sub.8-alkylcarbonyloxy; C.sub.1-C.sub.8-halogenoalkylcarbonyloxy; C.sub.3-C.sub.8-cycloalkylcarbonyloxy; C.sub.1-C.sub.8-alkylcarbonylamnino; C.sub.1-C.sub.8-halogenoalkylcarbonylamino; C.sub.1-C.sub.8-alkylaminocarbonyloxy; di-C.sub.1-C.sub.8-alkylaminocarbonyloxy; C.sub.1-C.sub.8-alkyloxycarbonyloxy; C.sub.1-C.sub.8-alkylsulfinyl; C.sub.1-C.sub.8-halogenoalkylsulfinyl; C.sub.1-C.sub.8-alkylsulfonyl; C.sub.1-C.sub.8-halogenoalkylsulfonyl; C.sub.1-C.sub.8-alkylsulfonyloxy; C.sub.1-C.sub.8-halogenoallkylsulfonyloxy; C.sub.1-C.sub.8-alkylaminosulfamoyl; di-C.sub.1-C.sub.8-alkylamninosulfamoyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; hydroxyimino-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.3-C.sub.7-cycloalkyl; hydroxyimino-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkylimino)-oxy; (C.sub.1-C.sub.8-alkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.7-cycloalkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.6-alkylimino)-oxy-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkenyloxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkynyloxyimino)-C.sub.1-C.sub.8-alkyl; (benzyloxyimino)-C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-alkoxyalkyl; C.sub.1-C.sub.8-alkylthioalkyl; C.sub.1-C.sub.8-alkoxyalkoxyalkyl; C.sub.1-C.sub.8-halogenoalkoxyalkyl; benzyl; phenyl; 5-membered heteroaryl; 6-membered heteroaryl; benzyloxy; phenyloxy; benzylsulfanyl; benzylamino; phenylsulfanyl; or phenylamino; R.sup.4 represents hydrogen, fluorine, C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-haloalkyl or C.sub.1-C.sub.8-alkyloxy; R.sup.5 represents hydrogen, fluorine, C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-haloalkyl or C.sub.1-C.sub.8-alkyloxy; or R.sup.4 and R.sup.5 form together with the carbon atom to which they are attached an optionally halogen-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl ring; Q represents a 6-membered aromatic cycle of formula (Q-I) ##STR00179## wherein U.sup.1 represents CX.sup.1 or N; wherein X.sup.1 represents hydrogen, halogen, nitro, cyano, hydroxy, sulfanyl, carboxaldehyde, substituted or non-substituted carbaldehyde O(C.sub.1-C.sub.8-alkyl)oxime, pentafluoro-.sup.6-sulfenyl group, substituted or non-substituted C.sub.1-C.sub.8-alkyl, substituted or non-substituted C.sub.3-C.sub.8-cycloalkyl, substituted or non-substituted C.sub.3-C.sub.7-halogencycloalkyl having 1 to 5 halogen atoms; substituted or non-substituted C.sub.3-C.sub.7-cycloalkenyl; substituted or non-substituted C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, a substituted or non-substituted C.sub.2-C.sub.8-alkenyl, substituted or non-substituted C.sub.2-C.sub.8-alkynyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxy, substituted or non-substituted C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfenyl, substituted or non-substituted C.sub.2-C.sub.8-alkenyloxy, substituted or non-substituted C.sub.3-C.sub.8-alkynyloxy, substituted or non-substituted C.sub.3-C.sub.6-cycloalkoxy, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-alkaninmidoyl, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-halogenoalkanimidoyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylanminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxycarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkylcarbonyloxy, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfinyl, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfonyl, substituted or non-substituted (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted hydroxyimino-C.sub.1-C.sub.8-alkyl, substituted or non-substituted phenyloxy, substituted or non-substituted phenylsulfenyl, substituted or non-substituted aryl, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyloxy, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heterocyclyloxy; U.sup.2 represents CX.sup.2 or N; wherein X.sup.2 represents hydrogen, halogen, nitro, cyano, hydroxy, sulfanyl, carboxaldehyde, substituted or non-substituted carbaldehyde O(C.sub.1-C.sub.8-alkyl)oxime, pentafluoro-.sup.6-sulfenyl group, substituted or non-substituted C.sub.1-C.sub.8-alkyl, substituted or non-substituted C.sub.3-C.sub.8-cycloalkyl, substituted or non-substituted C.sub.3-C.sub.7-halogencycloalkyl having 1 to 5 halogen atoms; substituted or non-substituted C.sub.3-C.sub.7-cycloalkenyl; substituted or non-substituted C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, a substituted or non-substituted C.sub.2-C.sub.8-alkenyl, substituted or non-substituted C.sub.2-C.sub.8-alkynyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxy, substituted or non-substituted C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfenyl, substituted or non-substituted C.sub.2-C.sub.8-alkenyloxy, substituted or non-substituted C.sub.3-C.sub.8-alkynyloxy, substituted or non-substituted C.sub.3-C.sub.6-cycloalkoxy, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-alkanimidoyl, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-halogenoalkanimidoyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxycarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkylcarbonyloxy, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfinyl, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfonyl, substituted or non-substituted (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted hydroxyimino-C.sub.1-C.sub.8-alkyl, substituted or non-substituted phenyloxy, substituted or non-substituted phenylsulfenyl, substituted or non-substituted aryl, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyloxy, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heterocyclyloxy; U.sup.3 represents CX.sup.3 or N; wherein X.sup.3 represents hydrogen, halogen, nitro, cyano, hydroxy, sulfanyl, carboxaldehyde, substituted or non-substituted carbaldehyde O(C.sub.1-C.sub.8-alkyl)oxime, pentafluoro-.sup.6-sulfenyl group, substituted or non-substituted C.sub.1-C.sub.8-alkyl, substituted or non-substituted C.sub.3-C.sub.8-cycloalkyl, substituted or non-substituted C.sub.3-C.sub.7-halogencycloalkyl having 1 to 5 halogen atoms; substituted or non-substituted C.sub.3-C.sub.7-cycloalkenyl; substituted or non-substituted C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, a substituted or non-substituted C.sub.2-C.sub.8-alkenyl, substituted or non-substituted C.sub.2-C.sub.8-alkynyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxy, substituted or non-substituted C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfenyl, substituted or non-substituted C.sub.2-C.sub.8-alkenyloxy, substituted or non-substituted C.sub.3-C.sub.8-alkynyloxy, substituted or non-substituted C.sub.3-C.sub.6-cycloalkoxy, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-alkaninmidoyl, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-halogenoalkanimidoyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxycarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkylcarbonyloxy, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfinyl, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfonyl, substituted or non-substituted (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted hydroxyimino-C.sub.1-C.sub.8-alkyl, substituted or non-substituted phenyloxy, substituted or non-substituted phenylsulfenyl, substituted or non-substituted aryl, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyloxy, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heterocyclyloxy; U.sup.4 represents CX.sup.4 or N; wherein X.sup.4 represents hydrogen, halogen, nitro, cyano, hydroxy, sulfanyl, carboxaldehyde, substituted or non-substituted carbaldehyde O(C.sub.1-C.sub.8-alkyl)oxime, pentafluoro-.sup.6-sulfenyl group, substituted or non-substituted C.sub.1-C.sub.8-alkyl, substituted or non-substituted C.sub.3-C.sub.8-cycloalkyl, substituted or non-substituted C.sub.3-C.sub.7-halogencycloalkyl having 1 to 5 halogen atoms; substituted or non-substituted C.sub.3-C.sub.7-cycloalkenyl; substituted or non-substituted C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, a substituted or non-substituted C.sub.2-C.sub.8-alkenyl, substituted or non-substituted C.sub.2-C.sub.8-alkynyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxy, substituted or non-substituted C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfenyl, substituted or non-substituted C.sub.2-C.sub.8-alkenyloxy, substituted or non-substituted C.sub.3-C.sub.8-alkynyloxy, substituted or non-substituted C.sub.3-C.sub.6-cycloalkoxy, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-alkanimidoyl, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-halogenoalkanimidoyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxycarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkylcarbonyloxy, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfinyl, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfonyl, substituted or non-substituted (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted hydroxyimino-C.sub.1-C.sub.8-alkyl, substituted or non-substituted phenyloxy, substituted or non-substituted phenylsulfenyl, substituted or non-substituted aryl, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyloxy, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heterocyclyloxy; U.sup.5 represents CX.sup.5 or N; wherein X.sup.5 represents hydrogen, halogen, nitro, cyano, hydroxy, sulfanyl, carboxaldehyde, substituted or non-substituted carbaldehyde O(C.sub.1-C.sub.8-alkyl)oxime, pentafluoro-.sup.6-sulfenyl group, substituted or non-substituted C.sub.1-C.sub.8-alkyl, substituted or non-substituted C.sub.3-C.sub.8-cycloalkyl, substituted or non-substituted C.sub.3-C.sub.7-halogencycloalkyl having 1 to 5 halogen atoms; substituted or non-substituted C.sub.3-C.sub.7-cycloalkenyl; substituted or non-substituted C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, a substituted or non-substituted C.sub.2-C.sub.8-alkenyl, substituted or non-substituted C.sub.2-C.sub.8-alkynyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxy, substituted or non-substituted C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfenyl, substituted or non-substituted C.sub.2-C.sub.8-alkenyloxy, substituted or non-substituted C.sub.3-C.sub.8-alkynyloxy, substituted or non-substituted C.sub.3-C.sub.6-cycloalkoxy, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-alkanimidoyl, substituted or non-substituted N(C.sub.1-C.sub.8-alkoxy)-C.sub.1-C.sub.8-halogenoalkanimidoyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkoxycarbonyl, substituted or non-substituted C.sub.1-C.sub.8-alkylcarbonyloxy, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfinyl, substituted or non-substituted C.sub.1-C.sub.8-alkylsulfonyl, substituted or non-substituted (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; substituted or non-substituted hydroxyimino-C.sub.1-C.sub.8-alkyl, substituted or non-substituted phenyloxy, substituted or non-substituted phenylsulfenyl, substituted or non-substituted aryl, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyloxy, substituted or non-substituted tri(C.sub.1-C.sub.8-alkyl)-silyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heterocyclyloxy; and wherein at most two of U.sup.1, U.sup.2, U.sup.3, U.sup.4 or U.sup.5 can represent N; or U.sup.1 and U.sup.2 or U.sup.2 and U.sup.3 or U.sup.3 and U.sup.4 form together an additional saturated or unsaturated 4 to 6-membered halogen- or C.sub.1-C.sub.8-alkyl-substituted or non-substituted ring; And/or a salt and/or N-oxide thereof.

    2. Imidazole derivative of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1, wherein R.sup.1 represents in each case optionally branched C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-haloalkyl, C.sub.2-C.sub.7-alkenyl, C.sub.2-C.sub.7-haloalkenyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl; R.sup.2 represents H, C.sub.1-C.sub.8-alkyl, halogen- or C.sub.1-C.sub.8-alkoxy-substituted or non-substituted C(O)C.sub.1-C.sub.8-alkyl; R.sup.3 represents halogen; hydroxyl; cyano; isocyano; nitro; carboxaldehyde, hydroxycarbonyl, C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-haloalkyl: C.sub.1-C.sub.8-cyanoalkyl; C.sub.1-C.sub.8-alkyloxy; C.sub.1-C.sub.8-halogenalkyloxy; C.sub.3-C.sub.7-cycloalkyl; C.sub.3-C.sub.7-halogencycloalkyl; C.sub.2-C.sub.8-alkenyl; C.sub.2-C.sub.8-alkynyl; C.sub.2-C.sub.8-alkenyloxy; C.sub.2-C.sub.8-halogenalkenyloxy; C.sub.3-C.sub.8-alkynyloxy; C.sub.3-C.sub.8-halogenoalkynyloxy; C.sub.1-C.sub.8-alkylsulfanyl; C.sub.1-C.sub.8-halogenoalkylsulfanyl; C.sub.1-C.sub.8-alkylcarbonyl; C.sub.1-C.sub.8-halogenoalkylcarbonyl; arylcarbonyl; aryl-C.sub.1-C.sub.6-alkylcarbonyl; C.sub.3-C.sub.8-cycloalkylcarbonyl; C.sub.3-C.sub.8-halogenocycloalkylcarbonyl; aminothiocarbonyl; C.sub.1-C.sub.8-alkoxycarbonyl; C.sub.1-C.sub.8-halogenoalkoxycarbonyl; C.sub.3-C.sub.8-cycloalkoxycarbonyl: C.sub.1-C.sub.8-alkylcarbonyloxy; C.sub.1-C.sub.8-halogenoalkylcarbonyloxy; C.sub.3-C.sub.8-cycloalkylcarbonyloxy; benzyl; phenyl; 5-membered heteroaryl; 6-membered heteroaryl: benzyloxy; or phenyloxy; wherein the benzyl, phenyl, 5-membered heteroaryl, 6-membered heteroaryl, benzyloxy or phenyloxy may be optionally substituted by one or more group(s) selected from halogen; hydroxyl; cyano; isocyano; amino; sulfanyl; pentafluoro-.sup.6-sulfanyl; C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-haloalkyl; C.sub.1-C.sub.8-alkyloxy; C.sub.1-C.sub.8-halogenalkyloxy; tri(C.sub.1-C.sub.8-alkyl)silyl; C.sub.3-C.sub.7-cycloalkyl; C.sub.2-C.sub.8-alkenyl; C.sub.2-C.sub.8-alkynyl; R.sup.4 represents hydrogen, fluorine, C.sub.1-C.sub.4-alkyl; R.sup.5 represents hydrogen, fluorine, C.sub.1-C.sub.4-alkyl; or R.sup.4 and R.sup.5 form together with the carbon atom to which they are attached an optionally halogen-, C.sub.1-C.sub.4-alkyl-substituted C.sub.3-C.sub.6-cycloalkyl ring; Q represents a 6-membered aromatic cycle of formula (Q-I-1) to (Q-I-10) ##STR00180## ##STR00181## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4 or X.sup.5 independent from each other have the same definition as given in claim 1; optionally independent from each other represent hydrogen or halogen.

    3. Imidazole derivative of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1, wherein Q represents a, optionally substituted, phenyl, 3-pyridyl or 4-pyridyl of formula (Q-I-1) to (Q-I-3) ##STR00182## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4 or X.sup.5 independent from each other have the same definition as given in claim 1 or 2; optionally independent from each other represent hydrogen or halogen.

    4. Imidazole derivative of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1, wherein R.sup.3 represents represents halogen; cyano; carboxaldehyde, hydroxycarbonyl, C.sub.1-C.sub.4-alkyl; C.sub.1-C.sub.4-haloalkyl; C.sub.1-C.sub.4-cyanoalkyl; C.sub.1-C.sub.4-alkyloxy; C.sub.1-C.sub.4-halogenalkyloxy; C.sub.3-C.sub.7-cycloalkyl: C.sub.3-C.sub.7-halogencycloalkyl; C.sub.2-C.sub.5-alkenyl; C.sub.2-C.sub.5-alkynyl; C.sub.1-C.sub.4-alkylsulfanyl; C.sub.1-C.sub.4-halogenoalkylsulfanyl; C.sub.1-C.sub.4-alkylcarbonyl; C.sub.1-C.sub.4-halogenoalkylcarbonyl; C.sub.1-C.sub.4-alkoxycarbonyl; C.sub.1-C.sub.4-halogenoalkoxycarbonyl; benzyl; phenyl; furyl; pyrrolyl; thienyl; pyridyl; benzyloxy; or phenyloxy; wherein the benzyl, phenyl, 5-membered heteroaryl, 6-membered heteroaryl, benzyloxy or phenyloxy may be optionally substituted by one or more group(s) selected from halogen; C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-haloalkyl; C.sub.1-C.sub.8-alkyloxy; C.sub.1-C.sub.8-halogenalkyloxy. Q represents a, optionally substituted, phenyl, 3-pyridyl or 4-pyridyl of formula (Q-I-1) to (Q-I-3) ##STR00183## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4 or X.sup.5 independent from each other have the same definition as given in claim 1; optionally independent from each other represent hydrogen or halogen.

    5. Method for controlling harmful microorganisms in crop protection and in the protection of one or more materials, comprising applying a compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1 to the harmful microorganisms and/or a habitat thereof.

    6. Method for controlling phytopathogenic harmful fungi in crop protection and in the protection of one or more materials, comprising applying a compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1 to the phytopathogenic harmful fungi and/or a habitat thereof.

    7. Composition for controlling harmful microorganisms, optionally for controlling phytopathogenic harmful fungi, comprising a content of at least one compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1, in addition to one or more extenders and/or surfactants.

    8. Composition according to claim 7 comprising at least one further active ingredient selected from the group consisting of insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth regulators, herbicides, fertilizers, safeners and semiochemicals.

    9. A product comprising a compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1 for control of harmful microorganisms, optionally phytopathogenic harmful fungi, in crop protection and/or for protection of one or more materials.

    10. Process for producing a composition for controlling harmful microorganisms, optionally for controlling phytopathogenic harmful fungi, comprising mixing a compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1 with one or more extenders and/or surfactants.

    11. A product comprising a compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1 for treatment of one or more transgenic plants.

    12. A product comprising a compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1 for treatment of seed and/or seed of transgenic plants.

    13. Compound of formula (XVII) ##STR00184## wherein R.sup.1 represents hydrogen, in each case optionally branched C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-haloalkyl, C.sub.2-C.sub.7-alkenyl, C.sub.2-C.sub.7-haloalkenyl, C.sub.2-C.sub.8-alkynyl, C.sub.2-C.sub.8-haloalkynyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted bicycloalkyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.8-cycloalkylalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-halocycloalkyl-C.sub.1-C.sub.4-alkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-halocycloalkyl-C.sub.1-C.sub.4-haloalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl-C.sub.1-C.sub.4-haloalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkyl-C.sub.3-C.sub.7-cycloalkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted C.sub.3-C.sub.7-cycloalkenyl, optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.1-C.sub.4-alkyl; optionally halogen-, cyano-, C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-haloalkyl-, C.sub.1-C.sub.4-alkoxy-, C.sub.1-C.sub.4-haloalkoxy-, C.sub.1-C.sub.4-alkylthio- or C.sub.1-C.sub.4-haloalkylthio-substituted tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.3-C.sub.7-cycloalkyl; and R.sup.3 represents halogen; hydroxyl; cyano; isocyano; nitro; amino; sulfanyl; pentafluoro-.sup.6-sulfanyl; carboxaldehyde, C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-haloalkyl; C.sub.1-C.sub.8-cyanoalkyl; C.sub.1-C.sub.8-alkyloxy; C.sub.1-C.sub.8-halogenalkyloxy; tri(C.sub.1-C.sub.8-alkyl)silyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.1-C.sub.8-alkyl; C.sub.3-C.sub.7-cycloalkyl; C.sub.3-C.sub.7-halogencycloalkyl; C.sub.3-C.sub.7-cycloalkenyl; C.sub.3-C.sub.7-halogencycloalkenyl; C.sub.4-C.sub.10-cycloalkylalkyl; C.sub.4-C.sub.10-halocycloalkylalkyl; C.sub.6-C.sub.12-cycloalkylcycloalkyl; C.sub.1-C.sub.8-alkyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.1-C.sub.8-alkoxy-C.sub.3-C.sub.7-cycloalkyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.2-C.sub.8-alkenyl; C.sub.2-C.sub.8-alkynyl; C.sub.2-C.sub.8-alkenyloxy; C.sub.2-C.sub.8-halogenalkenyloxy; C.sub.3-C.sub.8-alkynyloxy; C.sub.3-C.sub.8-halogenoalkynyloxy; C.sub.1-C.sub.8-alkylamino; C.sub.1-C.sub.8-halogenalkylamino; C.sub.1-C.sub.8-cyanoalkoxy: C.sub.4-C.sub.8-cycloalkylalkoxy; C.sub.3-C.sub.6-cycloalkoxy; C.sub.1-C.sub.8-alkylsulfanyl; C.sub.1-C.sub.8-halogenoalkylsulfanyl; C.sub.1-C.sub.8-alkylcarbonyl; C.sub.1-C.sub.8-halogenoalkylcarbonyl; arylcarbonyl; aryl-C.sub.1-C.sub.6-alkylcarbonyl; C.sub.3-C.sub.8-cycloalkylcarbonyl; C.sub.3-C.sub.8-halogenocycloalkylcarbonyl; C.sub.1-C.sub.8-alkylcarbamoyl; di-C.sub.1-C.sub.8-alkylcarbamoyl; NC.sub.1-C.sub.8-alkyloxycarbamoyl; C.sub.1-C.sub.8-alkoxycarbamoyl; NC.sub.1-C.sub.8-alkyl-C.sub.1-C.sub.8-alkoxycarbamoyl; aminothiocarbonyl; C.sub.2-C.sub.8-alkoxycarbonyl; C.sub.1-C.sub.8-halogenoalkoxycarbonyl; C.sub.3-C.sub.8-cycloalkoxycarbonyl; C.sub.2-C.sub.8-alkoxyalkylcarbonyl; C.sub.2-C.sub.8-halogenoalkoxyalkylcarbonyl; C.sub.3-C.sub.10-cycloalkoxyalkylcarbonyl: C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl; C.sub.3-C.sub.8-cycloalkylaminocarbonyl; C.sub.1-C.sub.8-alkylcarbonyloxy; C.sub.1-C.sub.8-halogenoalkylcarbonyloxy; C.sub.3-C.sub.8-cycloalkylcarbonyloxy; C.sub.1-C.sub.8-alkylcarbonylamino; C.sub.1-C.sub.8-halogenoalkylcarbonylamino; C.sub.1-C.sub.8-alkylaminocarbonyloxy; di-C.sub.1-C.sub.8-alkylaminocarbonyloxy; C.sub.1-C.sub.8-alkyloxycarbonyloxy; C.sub.1-C.sub.8-alkylsulfinyl; C.sub.1-C.sub.8-halogenoalkylsulfinyl; C.sub.1-C.sub.8-alkylsulfonyl; C.sub.1-C.sub.8-halogenoalkylsulfonyl; C.sub.1-C.sub.8-alkylsulfonyloxy; C.sub.1-C.sub.8-halogenoalkylsulfonyloxy; C.sub.1-C.sub.8-alkylaminosulfamoyl; di-C.sub.1-C.sub.8-alkylaminosulfamoyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; hydroxyimino-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.3-C.sub.7-cycloalkyl; hydroxyimino-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkylimino)-oxy; (C.sub.1-C.sub.8-alkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.7-cycloalkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.6-alkylimino)-oxy-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkenyloxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkynyloxyimino)-C.sub.1-C.sub.8-alkyl; (benzyloxyimino)-C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-alkoxyalkyl; C.sub.1-C.sub.8-alkylthioalkyl; C.sub.1-C.sub.8-alkoxyalkoxyalkyl; C.sub.1-C.sub.8-halogenoalkoxyalkyl; benzyl; phenyl; 5-membered heteroaryl; 6-membered heteroaryl; benzyloxy; phenyloxy; benzylsulfanyl; benzylamino; phenylsulfanyl; or phenylamino; wherein the benzyl, phenyl, 5-membered heteroaryl, 6-membered heteroaryl, benzyloxy or phenyloxy may be optionally substituted by one or more group(s) selected from halogen; hydroxyl; cyano; isocyano; amino; sulfanyl; pentafluoro-.sup.6-sulfanyl; carboxaldehyde, hydroxycarbonyl, C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-haloalkyl; C.sub.1-C.sub.8-cyanoalkyl; C.sub.1-C.sub.8-alkyloxy; C.sub.1-C.sub.8-halogenalkyloxy; tri(C.sub.1-C.sub.8-alkyl)silyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.1-C.sub.8-alkyl; C.sub.3-C.sub.7-cycloalkyl; C.sub.3-C.sub.7-halogencycloalkyl; C.sub.3-C.sub.7-cycloalkenyl; C.sub.3-C.sub.7-halogencycloalkenyl; C.sub.4-C.sub.10-cycloalkylalkyl; C.sub.4-C.sub.10-halocycloalkylalkyl; C.sub.6-C.sub.12-cycloalkylcycloalkyl; C.sub.1-C.sub.8-alkyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.1-C.sub.8-alkoxy-C.sub.3-C.sub.7-cycloalkyl; tri(C.sub.1-C.sub.8-alkyl)silyl-C.sub.3-C.sub.7-cycloalkyl; C.sub.2-C.sub.8-alkenyl; C.sub.2-C.sub.8-alkynyl; C.sub.2-C.sub.8-alkenyloxy; C.sub.2-C.sub.8-halogenalkenyloxy; C.sub.3-C.sub.8-alkynyloxy; C.sub.3-C.sub.8-halogenoalkynyloxy; C.sub.1-C.sub.8-alkylamino; C.sub.1-C.sub.8-halogenalkylamino; C.sub.1-C.sub.8-cyanoalkoxy; C.sub.4-C.sub.8-cycloalkylalkoxy; C.sub.3-C.sub.6-cycloalkoxy; C.sub.1-C.sub.8-alkylsulfanyl; C.sub.1-C.sub.8-halogenoalkylsulfanyl; C.sub.1-C.sub.8-alkylcarbonyl; C.sub.1-C.sub.8-halogenoalkylcarbonyl; arylcarbonyl; aryl-C.sub.1-C.sub.6-alkylcarbonyl; C.sub.3-C.sub.8-cycloalkylcarbonyl; C.sub.3-C.sub.8-halogenocycloalkylcarbonyl; C.sub.1-C.sub.8-alkylcarbamoyl; di-C.sub.1-C.sub.8-alkylcarbamoyl; NC.sub.1-C.sub.8-alkyloxycarbamoyl; C.sub.1-C.sub.8-alkoxycarbamoyl; NC.sub.1-C.sub.8-alkyl-C.sub.1-C.sub.8-alkoxycarbamoyl; amninothiocarbonyl; C.sub.1-C.sub.8-alkoxycarbonyl; C.sub.1-C.sub.8-halogenoalkoxycarbonyl; C.sub.3-C.sub.8-cycloalkoxycarbonyl; C.sub.2-C.sub.8-alkoxyalkylcarbonyl; C.sub.2-C.sub.8-halogenoalkoxyalkylcarbonyl; C.sub.3-C.sub.10-cycloalkoxyalkylcarbonyl; C.sub.1-C.sub.8-alkylaminocarbonyl; di-C.sub.1-C.sub.8-alkylaminocarbonyl; C.sub.3-C.sub.8-cycloalkylaminocarbonyl; C.sub.1-C.sub.8-alkylcarbonyloxy; C.sub.1-C.sub.8-halogenoalkylcarbonyloxy; C.sub.3-C.sub.8-cycloalkylcarbonyloxy; C.sub.1-C.sub.8-alkylcarbonylamino; C.sub.1-C.sub.8-halogenoalkylcarbonylamino; C.sub.1-C.sub.8-alkylaminocarbonyloxy; di-C.sub.1-C.sub.8-alkylaminocarbonyloxy; C.sub.1-C.sub.8-alkyloxycarbonyloxy; C.sub.1-C.sub.8-alkylsulfinyl; C.sub.1-C.sub.8-halogenoalkylsulfinyl; C.sub.1-C.sub.8-alkylsulfonyl; C.sub.1-C.sub.8-halogenoalkylsulfonyl; C.sub.1-C.sub.8-alkylsulfonyloxy; C.sub.1-C.sub.8-halogenoalkylsulfonyloxy; C.sub.1-C.sub.8-alkylaminosulfamoyl; di-C.sub.1-C.sub.8-alkylaminosulfamoyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.7-cycloalkoxyimino)-C.sub.1-C.sub.8-alkyl; hydroxyimino-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkoxyimino)-C.sub.3-C.sub.7-cycloalkyl; hydroxyimino-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkylimino)-oxy; (C.sub.1-C.sub.8-alkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.3-C.sub.7-cycloalkylimino)-oxy-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.6-alkylimino)-oxy-C.sub.3-C.sub.7-cycloalkyl; (C.sub.1-C.sub.8-alkenyloxyimino)-C.sub.1-C.sub.8-alkyl; (C.sub.1-C.sub.8-alkynyloxyimino)-C.sub.1-C.sub.8-alkyl; (benzyloxyimino)-C.sub.1-C.sub.8-alkyl; C.sub.1-C.sub.8-alkoxyalkyl; C.sub.1-C.sub.8-alkylthioalkyl; C.sub.1-C.sub.8-alkoxyalkoxyalkyl; C.sub.1-C.sub.8-halogenoalkoxyalkyl; benzyl; phenyl; 5-membered heteroaryl; 6-membered heteroaryl; benzyloxy; phenyloxy; benzylsulfanyl; benzylamino; phenylsulfanyl; or phenylamino; and/or a salt and/or N-oxide thereof.

    Description

    EXAMPLES

    Preparation Examples

    Preparation of Compounds of the Formula (I-27) According to Process H:

    Preparation of 2-(1-chlorocyclopropyl)-1-(4-chloro-2-fluorophenyl)-3-(5-chloro-1H-imidazol-1-yl)propan-2-ol (I-27)

    [0323] ##STR00029##

    [0324] A solution of 4-chloro-1H-imidazole (1.10 g, 4 eq, 10.7 mmol) and 2-(1-chlorocyclopropyl)-2-(4-chloro-2-fluorobenzyl)oxirane (700 mg, 1 eq, 2.68 mmol) in 5 mL acetonitrile was heated up to 150 C. by microwave irradiation for 90 min. Thereafter the reaction mixture was diluted with dichloromethane, the organic layer washed with sat. aq. NaHCO.sub.3 and dried (MgSO.sub.4), then concentrated to dryness in vacuo. The residue was purified by chromatography over silica gel, eluted with a mixture of n-heptane/ethyl acetate (100:0 to 50:50). After evaporation of the solvent 251 mg (24%) of 2-(1-chlorocyclopropyl)-1-(4-chloro-2-fluorophenyl)-3-(5-chloro-1H-imidazol-1-yl)propan-2-ol (I-27) were obtained as colourless solid.

    [0325] MS (ESI): 363.0 ([M+H].sup.+)

    Preparation of Compounds of the Formula (I-27) According to Process M:

    Preparation of 2-(1-chlorocyclopropyl)-1-(4-chloro-2-fluorophenyl)-3-(5-chloro-1H-imidazol-1-yl)propan-2-ol (I-27)

    [0326] ##STR00030##

    [0327] At 0-5 C. (ice/NaCl bath) a solution of 4-chloro-2-fluorobenzyl bromide (5.97 g, 26.7 mmol, 1.3 eq) in Et.sub.2O (5 mL) was added dropwise to a suspension of magnesium turnings (1.50 g, 61.6 mmol, 3.0 equiv; activated by stirring 1 h at rt under Argon in the presence of a catalytic amount of iodine) in Et.sub.2O (15 mL). The mixture was stirred 45 min at 5 C. Titration of the resulting solution using N-phenylsalicylhydrazone as an indicator (Love & Jones, J. Org. Chem. 1999, 64, 3755) gave the concentration as 1.2 M.

    [0328] To this solution at 5 C. was added a solution of 1-(1-chlorocyclopropyl)-2-(5-chloro-1H-imidazol-1-yl)ethanone (5.00 g, 20.5 mmol, 1.0 eq) in Et.sub.2O (30 mL) dropwise over 5 min. The reaction mixture was further stirred while allowed to warm up to room temperature over 1 h. To the resulting solution, cooled down to 5 C., was added sat. aq. NH.sub.4Cl. The resulting mixture was diluted with water, then extracted with ethyl acetate (320 mL). The combined organic layers were washed with sat. aq. NaHCO.sub.3, dried (MgSO.sub.4), then concentrated to dryness in vacuo. The oily residue was purified by chromatography over silica gel, eluted with a mixture of n-heptane/ethyl acetate (100:0 to 60:40). After evaporation of the solvent, followed by trituration in n-heptane:Et.sub.2O (50:50), a colourless solid precipitated which was filtered off and washed with n-heptane to afford 2.27 g (30%) of 2-(1-chlorocyclopropyl)-1-(4-chloro-2-fluorophenyl)-3-(5-chloro-1H-imidazol-1-yl)propan-2-ol (I-27) as a colourless solid.

    [0329] MS (ESI): 363.0 ([M+H].sup.+)

    Preparation of Compounds of the Formula (I-06) According to Process H:

    Preparation of 1-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile (I-06)

    [0330] ##STR00031##

    [0331] A solution of 4-cyano-1H-imidazole (500 mg, 1.0 eq, 5.37 mmol) and 2-(2-chlorobenzyl)-2-(1-chlorocyclopropyl)oxirane (1.96 g, 1.5 eq, 8.05 mmol) in a mixture of acetonitrile (3 mL) and DMF (1 mL) was heated up to 160 C. by microwave irradiation for 90 min. Thereafter the reaction mixture was diluted with dichloromethane, the organic layer washed with sat. aq. NaHCO.sub.3 and dried (MgSO.sub.4), then concentrated to dryness in vacuo. Purification of the residue by flash chromatography [over silica gel, eluted with a mixture of n-heptane/ethyl acetate (100:0 to 50:50)] followed by preparative HPLC afforded, after evaporation of the solvents, afforded 112 mg (6%) 1-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile (I-06) as a colourless oil.

    [0332] MS (ESI): 336.1 ([M+H].sup.+)

    Preparation of Compounds of the Formula (I-34) According to Process M:

    Preparation of 1-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile (I-34)

    [0333] ##STR00032##

    [0334] At 0-5 C. (ice/NaCl bath) a solution of 2-fluorobenzyl bromide (1.30 g, 6.86 mmol, 1.2 eq) in Et.sub.2O (5 mL) was added dropwise to a suspension of magnesium turnings (417 mg, 17.1 mmol, 3.0 equiv; activated by stirring at rt under Argon in the presence of a catalytic amount of iodine) in Et.sub.2O (15 mL). The mixture was stirred 45 min at 5 C.

    [0335] To this solution at 0-5 C. was added a solution of 1-[2-(1-chlorocyclopropyl)-2-oxoethyl]-1H-imidazole-5-carbonitrile (2.00 g, 60% purity, 5.72 mmol, 1.0 eq) in Et.sub.2O (30 mL) dropwise over 5 min. The reaction mixture was further stirred while allowed to warm up to room temperature over 1 h. To the resulting solution, cooled down to 5 C., was added sat. aq. NH.sub.4Cl. The resulting mixture was diluted with water, then extracted with ethyl acetate (320 mL). The combined organic layers were washed with sat. aq. NaHCO.sub.3, dried (MgSO.sub.4), then concentrated to dryness in vacuo. The oily residue was purified by chromatography over silica gel, eluted with a mixture of n-heptane/ethyl acetate (100:0 to 60:40). After evaporation of the solvent, 218 mg (12%) of 1-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile (I-34) were obtained as a yellow oil.

    [0336] MS (ESI): 320.1 ([M+H].sup.+)

    Preparation of Intermediates of the Formula (XII-1) According to Process D:

    Preparation of 2-(1-chlorocyclopropyl)-2-(4-chloro-2-fluorobenzyl)oxirane (XII-1)

    [0337] ##STR00033##

    [0338] To a solution of trimethylsulfoxonium chloride (2.50 g, 1.2 eq, 19.4 mmol) in THF (80 mL) at 0 C. and under Argon atmosphere was added sodium hydride (60% in mineral oil, 777 mg, 1.2 eq, 19.4 mmol). The resulting suspension was stirred at 0 C. for 30 min, then a solution of 1-(1-chlorocyclopropyl)-2-(4-chloro-2-fluorophenyl)ethanone (4.00 g, 1.0 eq, 16.1 mmol) in THF (10 mL) was added. The mixture was stirred for 2 h at 0 C., then for 20 h at room temperature. After careful addition of water, the obtained solution extracted with ethyl acetate. The organic phase was dried (MgSO.sub.4), then concentrated to dryness in vacuo. Purification by column chromatography over silica gel (eluent n-heptane/ethyl acetate 95:5) afforded, after evaporation of the solvent, 3.69 g (81%) of 2-(1-chlorocyclopropyl)-2-(4-chloro-2-fluorobenzyl)oxirane (XII-1) as a colourless oil.

    [0339] MS (EI): 260.0 ([M].sup.+)

    Preparation of Intermediates of the Formula (XVII) According to Process K:

    Preparation of 1-(1-chlorocyclopropyl)-2-(5-chloro-1H-imidazol-1-yl)ethanone (XVII-1)

    Step 1: Preparation of 1-allyl-4-chloro-1H-imidazole

    [0340] ##STR00034##

    [0341] To a solution of 4-chloro-1H-imidazole (180 g, 1.76 mol, 1.00 eq) in dry dichloromethane (3.0 L) at 0 C. was added aq. NaOH (1 M, 2.11 L, 2.11 mmol, 1.20 eq) followed by tetra-n-butylammonium bromide (56.6 g, 0.176 mol, 0.10 eq). To this biphasic solution was added dropwise allyl bromide (167 mL, 1.93 mol, 1.10 eq) and the resulting mixture was stirred at room temperature for 20 h. Thereafter the reaction mixture was diluted with water (1 L), extracted with dichloromethane (21 L), the combined organic layers were dried (MgSO.sub.4) and concentrated in vacuo, to provide 290 g of a mixture of regioisomers (80% purity, 93% yield), which were separated by distillation at reduced pressure (0.1 mbar).

    [0342] MS (EI): 142.1 ([M].sup.+)

    Step 2: Preparation of 1-allyl-4-chloro-3-[2-(1-chlorocyclopropyl)-2-oxoethyl]-1H-imidazol-3-ium iodide

    [0343] ##STR00035##

    [0344] A solution of 1-allyl-4-chloro-1H-imidazole (15.0 g, 105 mmol, 1 eq), 2-chloro-1-(1-chlorocyclopropyl)ethanone (19.3 g, 126 mmol, 1.20 eq) and potassium iodide (21.1 g, 127 mmol, 1.21 eq) in dry methanol (100 mL) was stirred at room temperature for 1 h, then at 70 C. for 21 h. Thereafter, the reaction mixture was concentrated in vacuo, and diluted with cold ethyl acetate, whereupon a solid precipitated. The precipitate was filtered off to afford 34.6 g (830%) of 1-allyl-4-chloro-3-[2-(1-chlorocyclopropyl)-2-oxoethyl]-1H-imidazol-3-ium iodide as an off-white solid.

    [0345] MS (ESI): 259.1 ([M-I].sup.+)

    Step 3: Preparation of 1-(1-chlorocyclopropyl)-2-(5-chloro-1H-imidazol-1-yl)ethanone (XVII-1)

    [0346] ##STR00036##

    [0347] To a solution of 1-allyl-4-chloro-3-[2-(1-chlorocyclopropyl)-2-oxoethyl]-1H-imidazol-3-ium iodide (28.54 g, 75.6 mmol, 1 eq) and morpholine (10.1 g, 115 mmol, 1.52 eq) in dry dichloromethane (150 mL), previously degassed by bubbling a flow of Argon through it for 10 min, was added tetrakis(triphenylphosphine)palladium(0) (1.12 g, 0.96 mmol, 0.013 eq). The resulting mixture was stirred at room temperature for 2 h30, then diluted with water and extracted with ethyl acetate (350 mL). The combined organic layers were washed with sat. aq. NH.sub.4Cl, dried and concentrated to dryness in vacuo. Purification by column chromatography over silica gel (eluent DCM/MeOH 100:0 to 60:40) afforded, after evaporation of the solvent, 12.5 g (58%) of 1-(1-chlorocyclopropyl)-2-(5-chloro-1H-imidazol-1-yl)ethanone (XVII-1) as an orange-coloured oil.

    [0348] MS (ESI): 219.1 ([M+H].sup.+)

    Preparation of 1-(1-chlorocyclopropyl)-2-(5-chloro-1H-imidazol-1-yl)ethanone (XVII-2)

    Step 1: Preparation of 1-allyl-1H-imidazole-4-carbonitrile

    [0349] ##STR00037##

    [0350] To a solution of 1-H-imidazole-5-carbonitrile (100 g, 1.02 mol, 1.00 eq) in dry dichloromethane (3.0 L) at 0 C. was added aq. NaOH (1 M, 1.23 L, 1.23 mmol, 1.20 eq) followed by tetra-n-butylammonium bromide (32.9 g, 0.102 mol, 0.10 eq). To this biphasic solution was added dropwise allyl bromide (92.7 mL, 1.07 mol, 1.05 eq) and the resulting mixture was stirred at room temperature for 20 h. Thereafter the reaction mixture was diluted with water (1 L), extracted with dichloromethane (21 L), the combined organic layers were dried (MgSO.sub.4) and concentrated in vacuo, to provide 163 g of a 75:25 mixture of regioisomers (80% purity, 96% yield), which were separated by distillation at reduced pressure (0.1-0.2 mbar).

    [0351] MS (EI): 133.1 ([M].sup.+)

    Step 2: Preparation of 1-allyl-3-[2-(1-chlorocyclopropyl)-2-oxoethyl]-4-cyano-1H-imidazol-3-ium iodide

    [0352] ##STR00038##

    [0353] A solution of 1-allyl-4-chloro-1H-imidazole (50.0 g, 375 mmol, 1 eq), 2-chloro-1-(1-chlorocyclopropyl)ethanone (68.9 g, 450 mmol, 1.20 eq) and potassium iodide (31.2 g, 187 mmol, 0.50 eq) in dry methanol (150 mL) was stirred at 70 C. for 46 h. Thereafter, the reaction mixture was concentrated in vacuo, and diluted with toluene. The resulting solution was extracted with water, the aqueous phase washed with diisopropyl ether, then concentrated to dryness in vacuo. The residue was dissolved in acetonitrile, the insoluble were filtered off and the filtrate concentrated to dryness in vacuo to afford 98.6 g (46%) of 1-allyl-3-[2-(1-chlorocyclopropyl)-2-oxoethyl]-4-cyano-1H-imidazol-3-ium iodide (purity 66%) as a brown oil.

    [0354] MS (ESI): 250.9 ([M-I].sup.+)

    Step 3: Preparation of 1-[2-(1-chlorocyclopropyl)-2-oxoethyl]-1H-imidazole-5-carbonitrile (XVII-2)

    [0355] ##STR00039##

    [0356] To a solution of 1-allyl-3-[2-(1-chlorocyclopropyl)-2-oxoethyl]-4-cyano-1H-imidazol-3-ium iodide (13.49 g, 67% purity, 23.9 mmol, 1 eq) and morpholine (2.51 g, 28.7 mmol, 1.2 eq) in dry dichloromethane (150 mL), previously degassed by bubbling a flow of Argon through it for 10 min, was added tetrakis(triphenylphosphine)palladium(0) (553 mg, 0.47 mmol, 0.020 eq). The resulting mixture was stirred at room temperature for 24 h, then diluted with water and extracted with dichloromethane. The combined organic layers were dried (MgSO.sub.4) and concentrated to dryness in vacuo. Purification by 2 column chromatographies over silica gel (first one: eluent DCM/MeOH 100:0 to 60:40; second one: eluent DCM /MeCN 100:0 to 95:5) afforded, after evaporation of the solvents, 5.12 g (55% purity, 56% yield) of 1-[2-(1-chlorocyclopropyl)-2-oxoethyl]-1H-imidazole-5-carbonitrile (XVII-2) as an orange-coloured oil.

    [0357] MS (ESI): 210.0 ([M+H].sup.+)

    Preparation of Compounds of the Formula (XVII-2) According to Process L:

    Preparation of 3-[2-(1-chlorocyclopropyl)-2-oxo-ethyl]imidazole-4-carbonitrile (XVII-2)

    [0358] ##STR00040##

    [0359] In a 500 mL teflon microwave reactor was placed 2-(5-bromoimidazol-1-yl)-1-(1-chlorocyclopropyl)ethanone (15.5 g, 1 eq, 58.8 mmol, 90% pure), Zn(CN).sub.2 (7.60 g, 1.1 eq, 64.7 mmol), and Pd(PPh.sub.3).sub.4 (13.6 g, 0.2 eq, 11.7 mmol) in DMF (230 mL). The reactor was placed in the microwave and heated at 160 C. for 10 min. The mixture was then concentrated, and taken up in a mixture of water and ethyl acetate. To remove the palladium salts, the mixture was passed over a silica plug which was washed with ethyl acetate. To the filtrate was added water, the phases were separated, and the aqueous phase was extracted three times with ethyl acetate. The combined organic extracts were then washed with an aqueous solution of LiCl, dried, and concentrated. The crude product was purified by chromatography over silica (gradient 100% DCM to 100% of a mixture DCM/MeOH=9/1 as eluent). After evaporation of the solvent 14.2 g (61% yield, 53% pure) of the target compound (XVII-2) (contaminated with Ph.sub.3P) was obtained as a brown oil which was used without further purification.

    [0360] MS (ESI): 210.0 ([M+H].sup.+)

    [0361] The following Table 1 illustrates in a non-limiting manner examples of compounds according to formula (I).

    TABLE-US-00001 TABLE 1 (I) [00041]embedded image Ex N Q R.sup.1 R.sup.2 R.sup.3 R.sup.4 R.sup.5 LogP I-01 2-chlorophenyl 1-chlorocyclopropyl H methoxycarbonyl H H 2.82.sup.[a] I-02 2-chlorophenyl 1-chlorocyclopropyl H chloro H H 2.32.sup.[a], 2.00.sup.[c] I-03 2-chlorophenyl 1-chlorocyclopropyl H methyl H H 1.72.sup.[a] I-04 2-chlorophenyl 1-chlorocyclopropyl H bromo H H 2.27.sup.[a] I-05 2-chlorophenyl 1-chlorocyclopropyl H chloro fluoro H 2.17.sup.[a] I-06 2-chlorophenyl 1-chlorocyclopropyl H cyano H H 2.92.sup.[a] I-07 2-chloropyridin-3-yl 1-chlorocyclopropyl H chloro H H 1.57.sup.[a] I-08 2-chloro-4-fluorophenyl 1-chlorocyclopropyl H chloro H H 2.47.sup.[a] I-09 2-chlorophenyl 1-chlorocyclopropyl H phenyl H H 2.30.sup.[a] I-10 2-chloropyridin-3-yl 1-chlorocyclopropyl H methyl H H 1.22.sup.[a] I-11 2,4-dichloropyridin-3-yl 1-chlorocyclopropyl H chloro H H 2.02.sup.[a] I-12 2-chlorophenyl 1-chlorocyclopropyl H formyl H H 2.80.sup.[a] I-13 2-chlorophenyl 1-chlorocyclopropyl H methyl fluoro H 1.75.sup.[a] I-14 2-chlorophenyl 1-chlorocyclopropyl H iodo H H 2.14.sup.[a] I-15 2-chlorophenyl 1-chlorocyclopropyl H trifluoromethyl H H 3.63.sup.[a] I-16 2-chlorophenyl 1-chlorocyclopropyl H fluoro H H 1.94.sup.[a] I-17 2,5-dichloropyridin-4-yl 1-chlorocyclopropyl H chloro H H 2.18.sup.[a] I-18 5-chloro-2-fluoropyridin-4-yl 1-chlorocyclopropyl H chloro H H 2.01.sup.[a] I-19 2-chlorophenyl 1-chlorocyclopropyl H acetyl H H 2.90.sup.[a] I-20 2-chlorophenyl 1-chlorocyclopropyl H 2-thienyl H H 2.21.sup.[a] I-21 2-chlorophenyl 1-chlorocyclopropyl H cyanomethyl H H 1.66.sup.[a] I-22 2-chlorophenyl 1-chlorocyclopropyl H methylthio H H 2.08.sup.[a] I-23 2-chlorophenyl 1-chlorocyclopropyl H bromo fluoro H 2.32.sup.[a] I-24 2-chlorophenyl 1-chlorocyclopropyl H cyano fluoro H 2.82.sup.[a] I-25 2-chloropyridin-3-yl 1-chlorocyclopropyl H bromo H H 1.56.sup.[a] I-26 2-chloropyridin-3-yl 1-chlorocyclopropyl H cyano H H 2.01.sup.[a] I-27(*) 4-chloro-2-fluorophenyl 1-chlorocyclopropyl H chloro H H 2.48.sup.[a] I-28 2-fluorophenyl 1-chlorocyclopropyl H chloro fluoro H 2.01.sup.[a] I-29(*) 4-chloro-2-fluorophenyl 1-chlorocyclopropyl H cyano H H 3.02.sup.[a] I-30 4-chloro-2-fluorophenyl 1-chlorocyclopropyl H bromo H H 2.55.sup.[a] I-31 2-fluorophenyl 1-chlorocyclopropyl H cyano fluoro H 2.51.sup.[a] I-32 2-fluorophenyl 1-chlorocyclopropyl H chloro H H 2.07.sup.[a] I-33 2-fluorophenyl 1-chlorocyclopropyl H bromo H H 2.10.sup.[a] I-34(*) 2-fluorophenyl 1-chlorocyclopropyl H cyano H H 2.64.sup.[a] I-35 2-fluorophenyl 1-chlorocyclopropyl H methoxy H H 1.67.sup.[a] I-36 2-fluorophenyl 1-chlorocyclopropyl H ethynyl H H 1.89.sup.[a] I-37 2-fluorophenyl 1-chlorocyclopropyl H cyclopropyl H H 1.86.sup.[a] I-38 2-chlorophenyl 1-chlorocyclopropyl H ethynyl H H 2.09.sup.[a] I-39 phenyl 1-chlorocyclopropyl H chloro H H 2.04.sup.[a] I-40 2-bromophenyl 1-chlorocyclopropyl H cyano H H 3.06.sup.[a] I-41 4-bromo-2-chlorophenyl 1-chlorocyclopropyl H cyano H H 3.52.sup.[a] I-42 4-bromo-2-fluorophenyl 1-chlorocyclopropyl H cyano H H 3.24.sup.[a] I-43 4-bromo-2-chlorophenyl 1-chlorocyclopropyl H chloro H H 3.02.sup.[a] I-44 4-bromo-2-fluorophenyl 1-chlorocyclopropyl H chloro H H 2.64.sup.[a] I-45 3-bromophenyl 1-chlorocyclopropyl H cyano H H 3.04.sup.[a] I-46 3-bromopyridin-4-y1 1-chlorocyclopropyl H cyano H H 1.94.sup.[a] I-47 2,5-dibromopyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.73.sup.[a] I-48 2,3-dibromopyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.60.sup.[a] I-49 2,3-dichlorophenyl 1-chlorocyclopropyl H cyano H H 3.25.sup.[a] I-50 2,3-dichloropyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.47.sup.[a] I-51 2,4-dimethylphenyl 1-chlorocyclopropyl H cyano H H 3.27.sup.[a] I-52 2,4-dichlorophenyl 1-chlorocyclopropyl H cyano H H 3.42.sup.[a] I-53 2-chloro-4-(4- 1-chlorocyclopropyl H cyano H H 4.54.sup.[a] chlorophenoxy)phenyl I-54 2-methylphenyl 1-chlorocyclopropyl H cyano H H 2.96.sup.[a] I-55 2-methoxyphenyl 1-chlorocyclopropyl H cyano H H 2.93.sup.[a] I-56 2,5-dichloropyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.62.sup.[a] I-57 3-chloropyridin-4-yl 1-chlorocyclopropyl H cyano H H 1.88.sup.[a] I-58 3,5-dichlorophenyl 1-chlorocyclopropyl H cyano H H 3.55.sup.[a] I-59 3-methylphenyl 1-chlorocyclopropyl H cyano H H 3.17.sup.[a] I-60 2-chloro-6-methylpyridin-4-yl 1-chlorocyclopropyl H cyano H H I-61 2,6-dichloropyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.66.sup.[a] I-62 2-chloropyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.04.sup.[a] I-63 biphenyl-4-yl 1-chlorocyclopropyl H cyano H H 3.68.sup.[a] I-64 4-chlorophenyl 1-chlorocyclopropyl H cyano H H 3.10.sup.[a] I-65 phenyl 1-chlorocyclopropyl H cyano H H 2.64.sup.[a] I-66 2,3-dichlorophenyl 1-chlorocyclopropyl H chloro H H 2.69.sup.[a] I-67 2,3-dichloropyridin-4-yl 1-chlorocyclopropyl H chloro H H 2.08.sup.[a] I-68 2,4-dimethylphenyl 1-chlorocyclopropyl H chloro H H 2.69.sup.[a] I-69 2,4-dichlorophenyl 1-chlorocyclopropyl H chloro H H 2.96.sup.[a] I-70 2-chloro-4-(4- 1-chlorocyclopropyl H chloro H H 4.06.sup.[a] chlorophenoxy)phenyl I-71 2-methylphenyl 1-chlorocyclopropyl H chloro H H 2.33.sup.[a] I-72 3-chloropyridin-4-yl 1-chlorocyclopropyl H chloro H H 1.52.sup.[a] I-73 3-methylphenyl 1-chlorocyclopropyl H chloro H H 2.30.sup.[a] I-74 2,6-dichloropyridin-4-yl 1-chlorocyclopropyl H chloro H H 2.23.sup.[a] I-75 2-chloropyridin-4-yl 1-chlorocyclopropyl H chloro H H 1.62.sup.[a] I-76 4-methylphenyl 1-chlorocyclopropyl H chloro H H 2.30.sup.[a] I-77 4-chlorophenyl 1-chlorocyclopropyl H chloro H H 2.45.sup.[a] I-78 2-chlorophenyl 1-chlorocyclopropyl H amino H H 1.50.sup.[a] I-79 2-chlorophenyl 1-methylcyclopropyl H cyano H H 2.87.sup.[a] I-80 2-chlorophenyl cyclopropyl H cyano H H 2.57.sup.[a] I-81 2-chlorophenyl cyclobutyl H cyano H H 2.96.sup.[a] I-82 2-chlorophenyl isopropyl H cyano H H 2.67.sup.[a] I-83 2-chlorophenyl 2,2-dimethylpropyl H cyano H H 3.55.sup.[a] I-84 2-chlorophenyl cyclopropylmethyl H cyano H H 2.84.sup.[a] I-85 2,3-dichlorophenyl cyclobutyl H cyano H H 3.31.sup.[a] I-86 4-chlorophenyl 2,2-dimethylpropyl H cyano H H 3.37.sup.[a] I-87 2-[1-(trifluoromethyl)- 1-chlorocyclopropyl H cyano H H 3.33.sup.[a] cyclopropyl]phenyl I-88 2-(trifluoromethyl)phenyl 1-chlorocyclopropyl H cyano H H 3.15.sup.[a] I-89 2-(trifluoromethyl)phenyl 1-chlorocyclopropyl H chloro H H 2.62[.sup.a] I-90 2-chloro-4-(trifluoromethyl)- 1-chlorocyclopropyl H cyano H H 3.42.sup.[a] phenyl I-91 2-chloro-4-(trifluoromethyl)- 1-chlorocyclopropyl H chloro H H 3.04.sup.[a] phenyl I-92 3-(trifluoromethyl)pyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.18.sup.[a] I-93 2,3,4-trifluorophenyl 1-fluorocyclopropyl H cyano H H 2.52.sup.[a] I-94 3-chloro-2-fluorophenyl 1-fluorocyclopropyl H cyano H H 2.68.sup.[a] I-95 2,3-difluorophenyl 1-fluorocyclopropyl H cyano H H 2.37.sup.[a] I-96 4-chloro-2-fluorophenyl 1-fluorocyclopropyl H cyano H H 2.78.sup.[a] I-97 2,4-difluorophenyl 1-fluorocyclopropyl H cyano H H 2.39.sup.[a] I-98 2-chlorophenyl 1-fluorocyclopropyl H cyano H H 2.53.sup.[a] I-99 2-fluorophenyl 1-fluorocyclopropyl H cyano H H 2.01.sup.[a] I-100 4-fluorophenyl 1-fluorocyclopropyl H cyano H H 2.35.sup.[a] I-101 3-chloro-2,4-difluorophenyl 1-chlorocyclopropyl H cyano H H 3.17.sup.[a] I-102 2,3,4-trifluorophenyl 1-methylcyclopropyl H cyano H H 2.82.sup.[a] I-103 2,3,4-trifluorophenyl 1-chlorocyclopropyl H cyano H H 2.92.sup.[a] I-104 2,3,4-trifluorophenyl cyclobutyl H cyano H H 2.78.sup.[a] I-105 2,3,4-trifluorophenyl isopropyl H cyano H H 2.78.sup.[a] I-106 2,3,4-trifluorophenyl cyclopropylmethyl H cyano H H 2.73.sup.[a] I-107 2-fluoro-4-methylphenyl 1-chlorocyclopropyl H cyano H H 2.97.sup.[a] I-108 2-fluoro-4-methylphenyl 1-chlorocyclopropyl H chloro H H 2.34.sup.[a] I-109 3,4-difluorophenyl 1-chlorocyclopropyl H cyano H H 2.78.sup.[a] I-110 3,4-difluorophenyl 1-chlorocyclopropyl H chloro H H 2.23.sup.[a] I-111(*) 4-chloro-2-fluorophenyl 1-chlorocyclopropyl H cyano H H 3.05.sup.[a] I-112(*) 4-chloro-2-fluorophenyl 1-chlorocyclopropyl H cyano H H 3.05.sup.[a] I-113(*) 4-chloro-2-fluorophenyl 1-chlorocyclopropyl H chloro H H 2.54.sup.[a] I-114(*) 4-chloro-2-fluorophenyl 1-chlorocyclopropyl H chloro H H I-115 4-chloro-2-fluorophenyl cyclopropyl H cyano H H 2.66.sup.[a] I-116 4-chloro-2-fluorophenyl cyclopropyl H carbamoyl H H 1.49.sup.[a] I-117 4-chloro-2-fluorophenyl cyclobutyl H cyano H H 3.31.sup.[a] I-118 4-chloro-2-fluorophenyl isopropyl H cyano H H 2.91.sup.[a] I-119 4-chloro-2-fluorophenyl 2,2-dimethylpropyl H cyano H H 3.71.sup.[a] I-120 4-chloro-2-fluorophenyl cyclopropylmethyl H cyano H H 2.95.sup.[a] I-121 4-chloro-2-fluorophenyl cyclopropyl methyl cyano H H 3.31.sup.[a] I-122 4-chloro-2-fluorophenyl 1-chlorocyclopropyl ethyl chloro H H 3.10.sup.[a] I-123 4-chloro-2-fluorophenyl 1-chlorocyclopropyl allyl chloro H H 3.31.sup.[a] I-124 2,4-difluorophenyl 1-methylcyclopropyl H cyano H H 2.65.sup.[a] I-125 2,4-difluorophenyl 1-chlorocyclopropyl H cyano H H 2.78.sup.[a] I-126 2,4-difluorophenyl 1-chlorocyclopropyl H chloro H H 2.20.sup.[a] I-127 2,4-difluorophenyl cyclobutyl H cyano H H 2.80.sup.[a] I-128 2,4-difluorophenyl isopropyl H cyano H H 2.52.sup.[a] I-129 2,4-difluorophenyl 2,2-dimethylpropyl H cyano H H 3.33.sup.[a] I-130 2,4-difluorophenyl cyclopropylmethyl H cyano H H 2.69.sup.[a] I-131 2-fluorophenyl 1-methylcyclopropyl H cyano H H 2.68.sup.[a] I-132(*) 2-fluorophenyl 1-chlorocyclopropyl H cyano H H 2.59.sup.[a] I-133(*) 2-fluorophenyl 1-chlorocyclopropyl H cyano H H 2.59.sup.[a] I-134 2-fluorophenyl 1-chlorocyclopropyl H (2- H H 3.60.sup.[a] fluorophenyl)acetyl I-135 2-fluorophenyl 1-chlorocyclopropyl H ethoxycarbonyl H H 2.73.sup.[a] I-136 2-fluorophenyl cyclopropyl H cyano H H 2.28.sup.[a] I-137 2-fluorophenyl cyclobutyl H cyano H H 2.46.sup.[a] I-138 2-fluorophenyl tert-butyl H cyano H H 2.73.sup.[a] I-139 2-fluorophenyl isopropyl H cyano H H 2.40.sup.[a] I-140 2-fluorophenyl 2,2-dimethylpropyl H cyano H H 3.23.sup.[a] I-141 2-fluorophenyl cyclopropylmethyl H cyano H H 2.45.sup.[a] I-142 2-fluoro-3-methylphenyl 1-chlorocyclopropyl H cyano H H 2.99.sup.[a] I-143 2-fluoro-3-methylphenyl 1-chlorocyclopropyl H chloro H H 2.35.sup.[a] I-144 2,3-difluorophenyl 1-methylcyclopropyl H cyano H H 2.75.sup.[a] I-145 3-chloro-2-fluorophenyl 1-chlorocyclopropyl H cyano H H 3.02.sup.[a] I-146 2,3-difluorophenyl 1-chlorocyclopropyl H cyano H H 2.75.sup.[a] I-147 2,3-difluorophenyl 1-chlorocyclopropyl H chloro H H 2.17.sup.[a] I-148 2,3-difluorophenyl cyclobutyl H cyano H H 2.57.sup.[a] I-149 2,3-difluorophenyl isopropyl H cyano H H 2.47.sup.[a] I-150 2,3-difluorophenyl 2,2-dimethylpropyl H cyano H H 3.27.sup.[a] I-151 2,3-difluorophenyl cyclopropylmethyl H cyano H H 2.66.sup.[a] I-152 2-chloro-3-fluoropyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.25.sup.[a] I-153 4-fluoro-2-methylphenyl 1-chlorocyclopropyl H cyano H H 2.96.sup.[a] I-154 2-chloro-4-fluorophenyl 1-chlorocyclopropyl H cyano H H 3.00.sup.[a] I-155 4-fluoro-2-methylphenyl 1-chlorocyclopropyl H chloro H H 2.46.sup.[a] I-156 3,5-difluorophenyl 1-chlorocyclopropyl H cyano H H 2.86.sup.[a] I-157 4-fluorophenyl 1-chlorocyclopropyl H cyano H H 2.75.sup.[a] I-158 4-fluorophenyl 1-chlorocyclopropyl H chloro H H 2.13.sup.[a] I-159 4-fluorophenyl 1-chlorocyclobutyl H cyano H H 2.98.sup.[a] I-160 4-fluorophenyl cyclobutyl H cyano H H 2.56.sup.[a] I-161 4-fluorophenyl cyclopentyl H cyano H H 2.82.sup.[a] I-162 4-fluorophenyl isopropyl H cyano H H 2.44.sup.[a] I-163 3-fluoropyridin-4-yl 1-chlorocyclopropyl H cyano H H 1.62.sup.[a] I-164 3-fluoropyridin-4-yl 1-chlorocyclopropyl H chloro H H 1.46.sup.[a] I-165 5-chloro-2-fluoropyridin-4-yl 1-chlorocyclopropyl H cyano H H 2.38.sup.[a] I-166 2-iodophenyl 1-chlorocyclopropyl H cyano H H 3.13.sup.[a] I-167 2-iodophenyl 1-chlorocyclopropyl H chloro H H 2.58.sup.[a] I-168 3-chloropyridazin-4-yl 1-chlorocyclopropyl H cyano H H 1.59.sup.[a] I-169 phenyl 1-chlorocyclopropyl H phenylacetyl H H 3.56.sup.[a] Optical rotation Concentration c is expressed in g/100 mL (*)Ex I-113 and I-114 are the 2 enantiomers of Ex I-27 Ex I-113: Optical rotation: 4 (c = 1.00, MeOH, 20 C.) Ex I-114: Optical rotation: +4 (c = 1.00, MeOH, 20 C.) (*)Ex I-111 and I-112 are the 2 enantiomers of Ex I-29 Ex I-111: Optical rotation: 12 (c = 1.00, MeOH, 25 C.) Ex I-112: Optical rotation: +12 (c = 1.00, MeOH, 25 C.) (*)Ex I-132 and I-133 are the 2 enantiomers of Ex I-34 Ex I-132: Optical rotation: 16.2 (c = 0.99, MeOH, 20 C.) Ex I-133: Optical rotation: +14.2 (c = 1.13, MeOH, 20 C.) Measurement of LogP values was performed according to EEC directive 79/831 Annex V.A8 by HPLC (High Performance Liquid Chomatography) on reversed phase columns with the following methods: .sup.[a]LogP value is determined by measurement of LC-UV, in an acidic range, with 0.1% formic acid in water and acetonitrile as eluent (linear gradient from 10% acetonitrile to 95% acetonitrile). .sup.[b]LogP value is determined by measurement of LC-UV, in a neutral range, with 0.001 molar ammonium acetate solution in water and acetonitrile as eluent (linear gradient from 10% acetonitrile to 95% acetonitrile). .sup.[c]LogP value is determined by measurement of LC-UV, in an acidic range, with 0.1% phosphoric acid and acetonitrile as eluent (linear gradient from 10% acetonitrile to 95% acetonitrile). If more than one LogP value is available within the same method, all the values are given and separated by +. Calibration was done with straight-chain alkan2-ones (with 3 to 16 carbon atoms) with known LogP values (measurement of LogP values using retention times with linear interpolation beween successive alkanones). Lambda-max-values were determined using UV-spectra from 200 nm to 400 nm and the peak values of the chromatographic signals.

    [0362] The following Table 2 illustrates in a non-limiting manner examples of compounds according to formula (XVII).

    TABLE-US-00002 TABLE 2 (XVII) [00042]embedded image Ex N R.sup.1 R.sup.3 LogP XVII-1 1-chlorocyclopropyl chloro 0.75.sup.[a] XVII-2 1-chlorocyclopropyl cyano 1.35.sup.[a] XVII-3 cyclopropyl cyano 0.74.sup.[a] XVII-4 1-fluorocyclopropyl cyano 1.05.sup.[a] XVII-5 1-chlorocyclopropyl fluoro 0.32.sup.[a] XVII-6 1-chlorocyclopropyl methoxycarbonyl 1.20.sup.[a] XVII-7 tert-butyl cyano 1.47.sup.[a] XVII-8 2-chloropropan-2-y1 cyano 1.65.sup.[a] XVII-9 1-cyanocyclopropyl cyano 0.90.sup.[a] XVII-10 1-chlorocyclopropyl iodo 0.70.sup.[a] XVII-11 2-fluoropropan-2-yl cyano 1.31.sup.[a] XVII-12 cyclopropylmethyl cyano 1.27.sup.[a] XVII-13 2,2-dimethylpropyl cyano 1.88.sup.[a] XVII-14 isopropyl cyano 1.14.sup.[a] XVII-15 cyclopentyl cyano 1.57.sup.[a] XVII-16 1-fluorocyclopentyl cyano 1.81.sup.[a] XVII-17 cyclobutyl cyano 1.26.sup.[a] XVII-18 1-chlorocyclobutyl cyano 1.86.sup.[a] XVII-19 butyl cyano 1.60.sup.[a]

    [0363] Measurement of Log P values was performed as outlined above.

    NMR-Peak Lists

    [0364] 1H-NMR data of selected examples are written in form of 1H-NMR-peak lists. To each signal peak are listed the -value in ppm and the signal intensity in round brackets. Between the -valuesignal intensity pairs are semicolons as delimiters.

    [0365] The peak list of an example has therefore the form:

    .sub.1 (intensity.sub.1); .sub.2 (intensity.sub.2); . . . ; .sub.i (intensity.sub.i); . . . ; .sub.n (intensity.sub.n)

    [0366] Intensity of sharp signals correlates with the height of the signals in a printed example of a NMR spectrum in cm and shows the real relations of signal intensities. From broad signals several peaks or the middle of the signal and their relative intensity in comparison to the most intensive signal in the spectrum can be shown.

    [0367] For calibrating chemical shift for 1H spectra, we use tetramethylsilane and/or the chemical shift of the solvent used, especially in the case of spectra measured in DMSO. Therefore in NMR peak lists, tetramethylsilane peak can occur but not necessarily.

    [0368] The 1H-NMR peak lists are similar to classical 1H-NMR prints and contains therefore usually all peaks, which are listed at classical NMR-interpretation.

    [0369] Additionally they can show like classical 1H-NMR prints signals of solvents, stereoisomers of the target compounds, which are also object of the invention, and/or peaks of impurities.

    [0370] To show compound signals in the delta-range of solvents and/or water the usual peaks of solvents, for example peaks of DMSO in DMSO-D.sub.6 and the peak of water are shown in our 1H-NMR peak lists and have usually on average a high intensity.

    [0371] The peaks of stereoisomers of the target compounds and/or peaks of impurities have usually on average a lower intensity than the peaks of target compounds (for example with a purity>90%).

    [0372] Such stereoisomers and/or impurities can be typical for the specific preparation process. Therefore their peaks can help to recognize the reproduction of our preparation process via side-products-fingerprints.

    [0373] An expert, who calculates the peaks of the target compounds with known methods (MestreC, ACD-simulation, but also with empirically evaluated expectation values) can isolate the peaks of the target compounds as needed optionally using additional intensity filters. This isolation would be similar to relevant peak picking at classical 1H-NMR interpretation.

    [0374] Further details of NMR-data description with peak lists you find in the publication Citation of NMR Peaklist Data within Patent Applications of the Research Disclosure Database Number 564025.

    Example I-01

    [0375] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.934 (2.9); 7.744 (2.8); 7.511 (1.1); 7.508 (1.2); 7.496 (1.2); 7.493 (1.3); 7.411 (1.1); 7.408 (1.1); 7.395 (1.5); 7.392 (1.4); 7.293 (0.5); 7.290 (0.6); 7.278 (1.4); 7.275 (1.3); 7.263 (1.2); 7.260 (1.1); 7.255 (1.1); 7.251 (1.2); 7.240 (1.2); 7.236 (1.2); 7.225 (0.5); 7.221 (0.4); 4.780 (1.7); 4.750 (2.2); 4.541 (2.2); 4.511 (1.8); 4.118 (4.3); 3.765 (16.0); 3.663 (2.0); 3.635 (2.2); 3.162 (1.9); 3.135 (1.8); 2.002 (1.6); 0.858 (0.4); 0.846 (0.6); 0.843 (0.6); 0.836 (0.6); 0.831 (0.8); 0.825 (0.8); 0.821 (0.7); 0.810 (0.7); 0.788 (0.5); 0.776 (0.5); 0.773 (0.7); 0.766 (0.8); 0.762 (0.5); 0.755 (0.7); 0.752 (0.9); 0.741 (0.6); 0.675 (0.7); 0.664 (0.8); 0.661 (0.7); 0.654 (0.6); 0.649 (0.8); 0.643 (0.7); 0.640 (0.5); 0.628 (0.5); 0.509 (0.6); 0.498 (0.7); 0.495 (0.7); 0.488 (0.7); 0.484 (0.7); 0.477 (0.6); 0.474 (0.7); 0.462 (0.5); 0.000 (2.8)

    Example I-02

    [0376] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.710 (12.0); 7.529 (0.4); 7.519 (5.2); 7.514 (5.4); 7.504 (4.7); 7.500 (6.2); 7.394 (5.2); 7.391 (4.1); 7.380 (6.1); 7.376 (6.7); 7.365 (0.8); 7.357 (0.5); 7.291 (0.3); 7.284 (1.5); 7.280 (2.3); 7.269 (6.7); 7.263 (11.5); 7.261 (8.8); 7.255 (12.3); 7.251 (6.4); 7.246 (6.7); 7.242 (5.7); 7.231 (2.3); 7.227 (1.8); 7.206 (0.5); 6.942 (12.3); 4.441 (9.2); 4.411 (12.5); 4.388 (0.3); 4.249 (12.1); 4.219 (9.2); 3.384 (5.3); 3.355 (13.7); 3.321 (14.9); 3.292 (6.1); 2.432 (5.3); 2.037 (1.1); 1.847 (0.9); 1.269 (0.4); 1.255 (0.7); 1.241 (0.3); 0.818 (0.6); 0.811 (1.3); 0.797 (3.1); 0.791 (6.5); 0.781 (12.8); 0.779 (13.4); 0.774 (16.0); 0.767 (5.5); 0.764 (6.8); 0.757 (5.5); 0.754 (5.7); 0.748 (2.2); 0.743 (1.8); 0.731 (1.0); 0.720 (1.5); 0.711 (0.9); 0.696 (2.6); 0.689 (5.0); 0.682 (3.8); 0.679 (4.7); 0.673 (2.4); 0.665 (3.5); 0.660 (2.5); 0.644 (0.7); 0.636 (0.3); 0.000 (5.1); 0.007 (0.3)

    Example I-03

    [0377] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.628 (1.1); 7.468 (1.7); 7.463 (1.7); 7.450 (1.9); 7.320 (1.9); 7.316 (1.6); 7.306 (2.0); 7.302 (2.3); 7.198 (0.9); 7.190 (5.6); 7.182 (3.2); 7.175 (4.1); 7.167 (2.6); 7.162 (2.0); 7.151 (0.6); 6.692 (1.4); 4.350 (2.3); 4.320 (2.6); 3.978 (2.5); 3.949 (2.2); 3.394 (0.3); 3.365 (0.3); 3.314 (0.7); 3.285 (6.2); 3.280 (6.4); 3.251 (0.6); 2.145 (0.4); 2.108 (16.0); 1.214 (0.9); 1.185 (7.0); 1.162 (0.8); 1.140 (0.4); 0.823 (0.6); 0.809 (1.1); 0.795 (0.7); 0.784 (0.4); 0.777 (0.4); 0.768 (0.4); 0.689 (5.2); 0.680 (2.0); 0.670 (1.1); 0.656 (0.4); 0.646 (1.0); 0.635 (2.0); 0.626 (4.6); 0.611 (1.1); 0.017 (0.4); 0.000 (17.0); 0.071 (3.6)

    Example I-04

    [0378] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.817 (6.8); 7.516 (5.8); 7.512 (5.8); 7.502 (5.9); 7.498 (6.6); 7.408 (0.5); 7.397 (6.9); 7.393 (5.9); 7.383 (7.9); 7.379 (8.8); 7.367 (0.7); 7.361 (0.4); 7.346 (0.4); 7.284 (2.5); 7.273 (7.1); 7.270 (7.5); 7.264 (8.6); 7.259 (16.9); 7.249 (7.4); 7.245 (6.2); 7.234 (2.3); 7.231 (1.7); 7.219 (0.5); 7.211 (0.6); 7.161 (0.4); 7.025 (12.3); 4.451 (8.8); 4.422 (12.8); 4.305 (12.6); 4.275 (8.9); 3.726 (0.4); 3.388 (8.3); 3.360 (15.4); 3.300 (16.0); 3.272 (8.7); 2.256 (3.1); 2.039 (1.5); 1.676 (0.6); 1.333 (0.4); 1.307 (0.5); 1.300 (0.4); 1.284 (0.6); 1.271 (1.0); 1.256 (2.8); 1.242 (0.7); 1.230 (1.3); 0.961 (0.4); 0.894 (0.3); 0.880 (0.6); 0.867 (0.4); 0.836 (1.0); 0.828 (2.0); 0.815 (3.2); 0.806 (6.3); 0.801 (6.0); 0.793 (10.5); 0.784 (15.4); 0.774 (7.1); 0.772 (6.9); 0.763 (4.7); 0.751 (1.7); 0.741 (0.5); 0.715 (0.7); 0.692 (2.3); 0.681 (4.3); 0.671 (6.4); 0.657 (3.5); 0.650 (2.1); 0.633 (0.4); 0.554 (0.4); 0.070 (2.8); 0.006 (1.2); 0.000 (34.5); 0.007 (1.8)

    Example I-05

    [0379] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.934 (3.4); 7.920 (3.6); 7.845 (10.1); 7.844 (9.5); 7.518 (3.1); 7.502 (5.2); 7.463 (2.0); 7.460 (1.3); 7.448 (3.7); 7.435 (1.6); 7.433 (2.2); 7.429 (1.4); 7.418 (2.8); 7.416 (2.8); 7.403 (3.8); 7.388 (1.5); 6.966 (9.9); 6.955 (9.1); 6.396 (6.3); 6.306 (6.4); 6.290 (11.7); 4.734 (4.8); 4.704 (6.0); 4.474 (3.7); 4.471 (3.9); 4.444 (3.2); 4.441 (3.0); 3.286 (20.7); 2.507 (2.3); 2.503 (4.9); 2.500 (6.7); 2.496 (4.9); 2.493 (2.5); 1.986 (0.4); 0.494 (0.7); 0.483 (1.6); 0.471 (7.7); 0.461 (16.0); 0.450 (2.3); 0.440 (0.7); 0.428 (0.5); 0.319 (0.5); 0.292 (3.2); 0.273 (1.8); 0.267 (1.6); 0.261 (1.2); 0.000 (3.7)

    Example I-06

    [0380] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.916 (15.7); 7.786 (15.0); 7.659 (4.8); 7.655 (5.2); 7.644 (4.5); 7.641 (5.6); 7.630 (0.4); 7.465 (5.0); 7.462 (4.1); 7.451 (6.2); 7.447 (6.4); 7.434 (0.4); 7.340 (1.4); 7.337 (2.0); 7.326 (5.6); 7.322 (5.8); 7.315 (6.2); 7.312 (8.5); 7.310 (8.4); 7.308 (5.7); 7.300 (5.5); 7.296 (5.0); 7.286 (1.8); 7.282 (1.3); 5.404 (16.0); 4.652 (7.3); 4.623 (7.9); 3.919 (8.8); 3.890 (8.4); 3.578 (7.8); 3.549 (8.7); 3.299 (11.7); 3.102 (8.1); 3.074 (7.3); 2.506 (2.2); 2.503 (3.0); 2.499 (2.2); 2.496 (1.1); 1.036 (1.8); 1.023 (2.9); 1.021 (2.9); 1.014 (2.8); 1.009 (2.8); 1.002 (3.2); 1.000 (3.2); 0.987 (2.3); 0.763 (1.8); 0.748 (2.8); 0.742 (2.9); 0.736 (2.6); 0.729 (3.2); 0.727 (3.4); 0.715 (2.4); 0.576 (2.2); 0.565 (3.2); 0.562 (2.9); 0.555 (2.5); 0.550 (3.2); 0.543 (2.8); 0.540 (2.3); 0.529 (2.0); 0.487 (2.4); 0.476 (2.6); 0.473 (3.0); 0.466 (3.1); 0.462 (2.6); 0.455 (2.5); 0.451 (2.7); 0.440 (1.7); 0.000 (1.9)

    Example I-07

    [0381] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =12.333 (1.1); 8.324 (0.5); 8.320 (0.6); 8.315 (0.6); 8.311 (0.6); 7.962 (0.5); 7.958 (0.6); 7.947 (0.6); 7.943 (0.6); 7.598 (13.0); 7.597 (13.1); 7.547 (1.2); 7.545 (1.3); 7.412 (0.6); 7.403 (0.6); 7.397 (0.6); 7.387 (0.6); 7.176 (16.0); 7.174 (15.9); 7.164 (1.8); 7.161 (1.5); 4.505 (0.8); 4.476 (0.9); 3.955 (0.8); 3.926 (0.8); 3.324 (0.8); 3.296 (1.1); 3.185 (1.0); 3.157 (0.7); 2.508 (1.7); 2.504 (2.4); 2.501 (1.8); 0.664 (0.3); 0.550 (0.4); 0.539 (0.4); 0.535 (0.4); 0.529 (0.5); 0.523 (0.5); 0.517 (0.4); 0.000 (1.2)

    Example I-08

    [0382] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.759 (9.6); 7.576 (3.6); 7.556 (3.8); 7.548 (4.2); 7.527 (3.9); 7.300 (20.4); 7.204 (3.8); 7.195 (4.2); 7.176 (3.8); 7.167 (4.1); 7.081 (2.5); 7.072 (2.3); 7.054 (3.6); 7.045 (3.2); 7.026 (2.6); 7.012 (10.2); 7.009 (9.9); 4.471 (5.4); 4.422 (10.1); 4.314 (9.6); 4.265 (5.2); 3.412 (4.0); 3.364 (8.3); 3.283 (9.2); 3.234 (4.4); 2.194 (14.0); 2.083 (1.0); 1.653 (16.0); 1.321 (0.5); 1.291 (3.1); 1.273 (0.6); 0.919 (0.3); 0.894 (0.6); 0.884 (1.0); 0.862 (2.1); 0.852 (2.7); 0.844 (3.1); 0.833 (6.9); 0.825 (8.4); 0.817 (9.3); 0.809 (2.9); 0.800 (4.0); 0.789 (3.6); 0.785 (3.5); 0.775 (1.3); 0.768 (1.0); 0.760 (1.1); 0.744 (0.7); 0.723 (1.1); 0.716 (1.3); 0.707 (4.4); 0.690 (3.4); 0.680 (1.4); 0.665 (1.8); 0.658 (1.2); 0.048 (0.6); 0.037 (14.4); 0.027 (0.6)

    Example I-09

    [0383] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.813 (12.6); 7.343 (6.3); 7.327 (9.5); 7.314 (9.9); 7.301 (21.2); 7.278 (9.4); 7.265 (18.3); 7.208 (3.1); 7.194 (6.1); 7.179 (4.2); 7.155 (5.3); 7.140 (6.6); 7.126 (2.9); 7.066 (12.8); 4.571 (6.5); 4.541 (8.3); 4.310 (8.1); 4.281 (6.7); 3.268 (6.4); 3.239 (8.1); 3.007 (7.7); 2.978 (6.4); 1.775 (4.0); 1.257 (2.0); 1.237 (0.7); 0.882 (0.6); 0.868 (0.4); 0.842 (0.4); 0.765 (1.8); 0.760 (1.9); 0.741 (6.9); 0.718 (10.6); 0.695 (3.8); 0.669 (3.8); 0.648 (16.0); 0.000 10.1)

    Example I-10

    [0384] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =8.363 (1.1); 8.308 (2.0); 8.304 (2.2); 8.299 (2.3); 8.295 (2.2); 8.157 (1.4); 8.154 (1.3); 8.142 (1.4); 7.586 (4.2); 7.445 (0.4); 7.399 (1.9); 7.390 (2.0); 7.384 (2.1); 7.374 (1.9); 6.847 (0.4); 6.572 (3.9); 4.382 (2.6); 4.352 (2.9); 3.835 (2.7); 3.806 (2.5); 3.317 (1.9); 3.289 (3.7); 3.257 (0.4); 3.233 (2.9); 3.205 (1.6); 2.893 (1.0); 2.733 (0.8); 2.507 (3.0); 2.504 (4.2); 2.500 (3.4); 2.279 (0.4); 2.111 (16.0); 2.087 (0.4); 2.073 (3.0); 2.063 (1.6); 1.987 (0.6); 1.234 (0.6); 1.176 (0.3); 1.036 (0.7); 1.032 (0.8); 1.021 (1.1); 1.008 (0.8); 0.679 (0.5); 0.664 (2.0); 0.660 (1.8); 0.650 (3.6); 0.630 (1.6); 0.610 (1.5); 0.594 (1.6); 0.582 (1.0); 0.000 (1.7)

    Example I-11

    [0385] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =8.238 (6.2); 8.227 (6.2); 8.142 (0.5); 8.131 (0.5); 7.673 (9.6); 7.620 (0.9); 7.359 (6.4); 7.349 (6.1); 7.272 (3.6); 6.901 (9.9); 6.889 (0.5); 6.657 (0.5); 6.646 (0.5); 4.694 (5.7); 4.664 (6.2); 4.596 (0.4); 4.566 (0.7); 4.448 (0.6); 4.418 (0.4); 4.125 (4.9); 4.095 (4.4); 3.691 (0.5); 3.661 (16.0); 3.641 (0.7); 3.631 (0.4); 3.237 (0.6); 3.203 (0.5); 2.651 (8.1); 1.878 (2.3); 1.359 (0.4); 1.346 (0.4); 1.114 (0.4); 1.096 (0.4); 0.996 (0.5); 0.984 (2.1); 0.975 (2.7); 0.968 (2.7); 0.962 (5.6); 0.954 (3.1); 0.947 (3.7); 0.941 (3.6); 0.928 (1.3); 0.879 (2.2); 0.866 (3.2); 0.857 (1.7); 0.853 (2.3); 0.845 (2.2); 0.831 (1.5); 0.745 (2.0); 0.733 (2.0); 0.729 (2.2); 0.725 (2.2); 0.718 (1.8); 0.713 (1.9); 0.709 (1.9); 0.697 (1.2); 0.000 (2.4)

    Example I-12

    [0386] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =9.532 (13.6); 8.008 (11.8); 7.826 (13.8); 7.506 (4.9); 7.503 (5.0); 7.491 (5.5); 7.488 (5.5); 7.416 (5.1); 7.401 (6.1); 7.400 (6.1); 7.313 (2.5); 7.300 (5.8); 7.299 (5.6); 7.286 (4.1); 7.273 (4.4); 7.269 (4.6); 7.261 (8.9); 7.255 (5.0); 7.242 (2.0); 7.239 (1.8); 4.806 (7.1); 4.776 (8.5); 4.480 (8.6); 4.450 (7.2); 4.041 (0.8); 3.904 (0.5); 3.897 (1.0); 3.827 (16.0); 3.702 (7.7); 3.674 (8.5); 3.132 (7.8); 3.104 (7.1); 2.837 (0.4); 1.663 (5.9); 0.908 (1.7); 0.897 (2.9); 0.894 (2.8); 0.887 (2.6); 0.882 (3.1); 0.875 (3.2); 0.873 (3.0); 0.861 (2.7); 0.817 (2.1); 0.803 (3.0); 0.796 (3.2); 0.791 (2.4); 0.782 (3.7); 0.770 (2.4); 0.682 (2.7); 0.671 (3.5); 0.668 (3.2); 0.661 (2.5); 0.657 (3.1); 0.650 (2.7); 0.635 (1.9); 0.530 (2.6); 0.518 (3.1); 0.516 (3.3); 0.508 (3.0); 0.505 (2.9); 0.497 (2.8); 0.494 (2.8); 0.483 (1.8); 0.000 (4.5)

    Example I-13

    [0387] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.944 (1.9); 7.929 (2.0); 7.817 (0.4); 7.814 (0.3); 7.665 (4.2); 7.519 (2.4); 7.503 (2.8); 7.462 (1.2); 7.447 (2.3); 7.432 (1.4); 7.420 (1.9); 7.418 (1.9); 7.404 (2.2); 7.390 (0.9); 6.928 (0.7); 6.620 (3.6); 6.379 (3.0); 6.360 (0.5); 6.290 (3.2); 6.284 (1.1); 6.271 (0.5); 6.179 (4.8); 4.712 (0.4); 4.682 (0.5); 4.650 (2.4); 4.620 (2.9); 4.399 (0.3); 4.365 (0.4); 4.356 (1.9); 4.354 (1.9); 4.339 (0.4); 4.335 (0.4); 4.326 (1.7); 3.299 (0.7); 2.890 (1.0); 2.732 (0.9); 2.503 (2.7); 2.500 (3.4); 2.496 (2.5); 2.278 (16.0); 2.163 (0.9); 2.092 (2.7); 1.236 (1.0); 0.877 (0.4); 0.436 (0.5); 0.426 (0.8); 0.414 (4.5); 0.410 (3.5); 0.396 (3.9); 0.384 (1.4); 0.373 (0.9); 0.268 (1.1); 0.260 (2.3); 0.246 (1.7); 0.236 (0.9); 0.229 (0.5); 0.164 (0.3); 0.000 (1.2)

    Example I-14

    [0388] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.901 (15.1); 7.518 (6.0); 7.514 (6.5); 7.503 (5.7); 7.499 (7.0); 7.417 (0.3); 7.402 (6.2); 7.399 (5.1); 7.387 (7.9); 7.383 (7.7); 7.370 (0.4); 7.291 (2.1); 7.288 (2.7); 7.277 (7.3); 7.273 (7.5); 7.265 (8.8); 7.263 (10.2); 7.260 (11.4); 7.258 (11.7); 7.250 (6.7); 7.246 (5.9); 7.235 (2.2); 7.231 (1.7); 7.137 (0.4); 7.120 (16.0); 7.011 (0.4); 7.008 (0.3); 6.944 (0.5); 5.201 (0.9); 4.464 (10.8); 4.434 (14.7); 4.280 (13.8); 4.250 (10.2); 3.387 (7.8); 3.358 (14.4); 3.295 (16.0); 3.267 (8.8); 2.368 (0.7); 2.199 (12.4); 2.178 (1.7); 1.615 (1.6); 1.257 (0.6); 0.854 (0.4); 0.842 (1.4); 0.836 (2.2); 0.825 (5.2); 0.819 (3.6); 0.810 (7.2); 0.800 (6.9); 0.793 (6.9); 0.790 (11.7); 0.784 (15.1); 0.775 (6.5); 0.768 (9.6); 0.758 (3.3); 0.755 (1.8); 0.724 (0.5); 0.700 (1.4); 0.688 (4.0); 0.684 (4.6); 0.674 (7.3); 0.667 (2.6); 0.659 (3.1); 0.655 (2.6); 0.648 (0.4); 0.639 (0.7); 0.069 (2.1); 0.006 (1.2); 0.000 (31.8); 0.007 (1.3)

    Example I-15

    [0389] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.925 (14.4); 7.616 (0.4); 7.517 (0.4); 7.508 (5.2); 7.502 (5.1); 7.493 (4.3); 7.489 (6.2); 7.458 (0.4); 7.442 (11.1); 7.421 (0.4); 7.393 (5.5); 7.389 (4.0); 7.387 (3.3); 7.379 (5.6); 7.374 (6.8); 7.365 (0.8); 7.301 (0.5); 7.299 (0.5); 7.293 (1.5); 7.289 (2.3); 7.278 (6.9); 7.274 (7.8); 7.272 (8.1); 7.266 (14.1); 7.260 (7.2); 7.257 (6.9); 7.253 (5.6); 7.242 (1.8); 7.238 (1.2); 4.593 (0.3); 4.500 (7.2); 4.470 (14.3); 4.414 (11.4); 4.384 (5.7); 3.999 (0.4); 3.971 (0.3); 3.433 (0.5); 3.394 (7.6); 3.382 (0.7); 3.365 (9.8); 3.354 (0.6); 3.174 (11.5); 3.145 (9.0); 2.451 (0.6); 2.322 (16.0); 1.643 (1.4); 1.255 (1.0); 0.903 (1.3); 0.892 (3.1); 0.887 (2.7); 0.877 (5.2); 0.872 (5.3); 0.866 (3.7); 0.858 (8.2); 0.853 (5.8); 0.840 (8.5); 0.832 (11.9); 0.824 (6.0); 0.818 (3.1); 0.814 (1.5); 0.809 (3.9); 0.804 (2.8); 0.800 (1.2); 0.789 (1.8); 0.684 (0.4); 0.665 (3.2); 0.657 (4.3); 0.655 (4.4); 0.646 (5.0); 0.637 (3.3); 0.633 (3.3); 0.622 (2.6); 0.071 (1.9); 0.006 (0.7); 0.000 (15.4); 0.007 (1.0)

    Example I-16

    [0390] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.511 (0.5); 7.503 (4.7); 7.497 (4.1); 7.491 (2.8); 7.488 (3.4); 7.484 (5.4); 7.476 (0.4); 7.422 (0.4); 7.414 (4.8); 7.410 (3.1); 7.407 (2.6); 7.400 (4.5); 7.395 (6.0); 7.386 (0.5); 7.298 (12.3); 7.283 (6.5); 7.279 (7.8); 7.278 (8.0); 0.271 (13.5); 7.263 (21.7); 7.259 (5.2); 7.248 (1.5); 7.244 (1.0); 6.532 (6.0); 6.531 (5.9); 6.517 (6.1); 6.515 (5.9); 4.444 (9.5); 4.415 (10.7); 3.999 (9.5); 3.969 (8.4); 3.422 (4.3); 3.394 (14.0); 3.371 (13.3); 3.342 (4.0); 2.396 (11.9); 1.722 (2.1); 1.255 (0.5); 0.784 (0.8); 0.776 (0.9); 0.774 (0.8); 0.766 (5.4); 0.756 (16.0); 0.747 (5.4); 0.741 (2.3); 0.738 (5.4); 0.730 (2.4); 0.726 (0.8); 0.717 (1.8); 0.712 (1.9); 0.704 (4.9); 0.696 (4.8); 0.694 (6.1); 0.689 (4.1); 0.675 (5.7); 0.666 (4.9); 0.654 (2.6); 0.650 (1.8); 0.632 (0.4); 0.070 (1.1); 0.006 (0.5); 0.000 (12.1); 0.007 (0.4)

    Example I-17

    [0391] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =8.368 (16.0); 7.711 (7.4); 7.561 (15.6); 7.262 (2.8); 6.973 (8.5); 4.459 (6.8); 4.429 (9.3); 4.278 (9.2); 4.248 (6.9); 3.386 (6.1); 3.358 (8.7); 3.236 (9.4); 3.208 (6.7); 2.537 (0.8); 2.043 (0.7); 1.258 (0.7); 1.255 (0.6); 0.895 (0.9); 0.889 (0.8); 0.884 (1.0); 0.882 (1.6); 0.869 (3.8); 0.863 (9.1); 0.859 (11.2); 0.844 (2.8); 0.839 (0.9); 0.836 (1.2); 0.830 (2.1); 0.824 (0.7); 0.794 (2.0); 0.788 (1.3); 0.776 (2.8); 0.764 (8.3); 0.756 (8.2); 0.751 (4.0); 0.742 (2.1); 0.735 (1.1); 0.730 (1.0); 0.724 (1.1); 0.070 (1.6); 0.006 (0.8); 0.000 (23.9); 0.007 (1.3)

    Example I-18

    [0392] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =8.198 (16.0); 7.687 (12.8); 7.266 (1.4); 7.215 (10.7); 7.210 (11.0); 6.921 (13.5); 4.451 (9.2); 4.421 (12.8); 4.278 (12.7); 4.249 (9.4); 3.423 (8.3); 3.395 (11.7); 3.266 (10.7); 3.238 (7.8); 3.221 (0.4); 3.183 (2.1); 2.006 (0.4); 0.879 (0.8); 0.876 (1.2); 0.873 (1.2); 0.865 (3.7); 0.861 (2.6); 0.857 (4.5); 0.852 (6.5); 0.847 (9.1); 0.843 (10.2); 0.831 (2.8); 0.828 (3.0); 0.825 (1.9); 0.821 (1.3); 0.813 (3.4); 0.807 (6.3); 0.796 (13.9); 0.792 (7.0); 0.783 (2.7); 0.779 (2.3); 0.773 (1.2); 0.763 (0.3); 0.071 (0.5); 0.006 (0.3); 0.000 (11.2); 0.007 (0.6)

    Example I-19

    [0393] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.975 (3.0); 7.827 (3.0); 7.528 (1.0); 7.525 (1.1); 7.513 (1.2); 7.509 (1.3); 7.408 (1.1); 7.406 (1.2); 7.392 (1.4); 7.390 (1.5); 7.315 (0.6); 7.312 (0.6); 7.300 (1.4); 7.297 (1.3); 7.285 (0.9); 7.282 (0.8); 7.262 (1.0); 7.258 (1.0); 7.246 (1.2); 7.243 (1.2); 7.231 (0.5); 7.228 (0.5); 4.761 (1.7); 4.732 (2.1); 4.478 (2.2); 4.468 (4.1); 4.449 (1.8); 3.729 (2.0); 3.702 (2.2); 3.090 (1.9); 3.062 (1.7); 2.420 (16.0); 0.930 (0.5); 0.919 (0.6); 0.915 (0.7); 0.908 (0.7); 0.904 (0.8); 0.897 (0.8); 0.894 (0.8); 0.882 (0.7); 0.811 (0.5); 0.799 (0.5); 0.796 (0.7); 0.789 (0.8); 0.785 (0.6); 0.778 (0.7); 0.775 (0.9); 0.764 (0.7); 0.687 (0.7); 0.676 (0.8); 0.672 (0.7); 0.666 (0.6); 0.661 (0.8); 0.655 (0.7); 0.651 (0.5); 0.640 (0.5); 0.521 (0.6); 0.510 (0.7); 0.506 (0.7); 0.499 (0.7); 0.495 (0.7); 0.488 (0.6); 0.485 (0.7); 0.474 (0.5); 0.000 (1.4)

    Example I-20

    [0394] .sup.1H-NMR (400.1 MHz, CDCl.sub.3): =7.822 (15.7); 7.820 (16.0); 7.585 (0.9); 7.582 (0.9); 7.545 (0.5); 7.542 (0.6); 7.537 (0.5); 7.534 (0.5); 7.498 (0.3); 7.475 (0.4); 7.426 (0.4); 7.409 (0.4); 7.403 (0.6); 7.380 (6.2); 7.375 (7.1); 7.365 (6.5); 7.361 (12.5); 7.357 (10.3); 7.348 (7.7); 7.342 (7.6); 7.327 (0.5); 7.313 (0.9); 7.305 (0.8); 7.300 (0.7); 7.293 (0.6); 7.287 (0.8); 7.282 (1.4); 7.277 (9.6); 7.274 (10.4); 7.264 (12.4); 7.260 (40.3); 7.248 (2.4); 7.242 (3.0); 7.229 (7.7); 7.224 (7.1); 7.214 (8.3); 7.212 (9.8); 7.209 (9.6); 7.205 (6.2); 7.196 (8.0); 7.192 (6.2); 7.178 (2.3); 7.174 (1.8); 7.164 (0.4); 7.146 (16.5); 7.143 (16.7); 7.131 (0.3); 6.970 (8.0); 6.961 (12.0); 6.957 (7.4); 6.948 (11.5); 6.926 (11.6); 6.923 (12.3); 6.917 (8.0); 6.914 (7.4); 4.600 (10.7); 4.563 (14.8); 4.386 (14.5); 4.349 (10.5); 4.003 (0.7); 3.967 (0.6); 3.494 (0.5); 3.458 (0.8); 3.366 (10.9); 3.330 (14.4); 3.138 (12.2); 3.102 (9.1); 2.000 (1.6); 1.954 (9.0); 1.690 (4.5); 1.257 (0.4); 0.834 (3.3); 0.827 (2.2); 0.821 (1.4); 0.818 (2.4); 0.814 (3.4); 0.801 (9.6); 0.793 (2.8); 0.779 (9.7); 0.776 (8.3); 0.771 (5.1); 0.764 (0.7); 0.751 (6.4); 0.747 (3.4); 0.739 (7.6); 0.731 (1.1); 0.727 (0.7); 0.719 (5.0); 0.713 (12.1); 0.710 (14.7); 0.706 (13.8); 0.694 (3.8); 0.689 (2.5); 0.681 (1.4); 0.674 (2.4); 0.664 (0.5); 0.655 (0.5); 0.651 (0.5); 0.645 (0.5); 0.640 (0.5); 0.635 (0.4); 0.070 (1.0); 0.008 (0.5); 0.000 (17.4); 0.009 (0.6)

    Example I-21

    [0395] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.658 (5.5); 7.654 (6.4); 7.649 (16.0); 7.647 (15.7); 7.643 (7.4); 7.639 (6.6); 7.471 (5.7); 7.468 (5.5); 7.456 (7.3); 7.453 (7.0); 7.367 (0.4); 7.357 (2.3); 7.354 (2.5); 7.342 (6.4); 7.339 (6.1); 7.328 (5.5); 7.324 (6.3); 7.322 (6.4); 7.318 (5.7); 7.307 (5.5); 7.303 (5.6); 7.292 (2.2); 7.288 (1.8); 6.836 (12.6); 6.835 (12.3); 5.283 (13.0); 4.524 (5.7); 4.494 (6.1); 3.972 (3.5); 3.971 (3.4); 3.935 (12.7); 3.910 (12.1); 3.909 (11.7); 3.873 (3.2); 3.871 (3.1); 3.819 (0.8); 3.818 (0.8); 3.712 (8.4); 3.682 (8.1); 3.625 (7.7); 3.597 (8.4); 3.324 (29.6); 3.043 (7.7); 3.014 (7.1); 2.505 (3.4); 2.502 (4.6); 2.498 (3.4); 2.072 (15.1); 1.067 (1.7); 1.053 (3.1); 1.046 (2.8); 1.041 (2.7); 1.033 (3.3); 1.032 (3.2); 1.019 (2.1); 0.755 (1.7); 0.740 (2.8); 0.734 (3.0); 0.728 (2.6); 0.721 (3.3); 0.719 (3.4); 0.707 (2.3); 0.586 (2.2); 0.575 (3.3); 0.572 (3.1); 0.565 (2.6); 0.561 (3.2); 0.553 (2.7); 0.551 (2.4); 0.539 (1.9); 0.441 (2.2); 0.429 (2.7); 0.426 (3.0); 0.420 (3.0); 0.415 (2.7); 0.408 (2.6); 0.405 (2.7); 0.393 (1.7); 0.000 (2.6)

    Example I-22

    [0396] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =7.811 (2.3); 7.808 (2.4); 7.616 (0.8); 7.609 (0.8); 7.600 (0.5); 7.597 (0.7); 7.592 (1.0); 7.430 (0.9); 7.426 (0.6); 7.423 (0.5); 7.413 (0.9); 7.407 (1.2); 7.307 (0.4); 7.293 (1.2); 7.288 (1.2); 7.285 (1.3); 7.277 (2.4); 7.270 (1.1); 7.267 (1.1); 7.261 (1.0); 7.248 (0.4); 7.071 (2.5); 7.069 (2.6); 5.108 (2.7); 4.471 (1.0); 4.435 (1.3); 4.176 (1.6); 4.140 (1.3); 3.266 (1.1); 3.230 (1.7); 3.130 (1.5); 3.095 (1.0); 2.511 (0.4); 2.506 (0.8); 2.502 (1.1); 2.497 (0.8); 2.493 (0.4); 2.210 (16.0); 0.956 (0.3); 0.951 (0.4); 0.938 (0.6); 0.931 (0.5); 0.925 (0.5); 0.918 (0.5); 0.811 (0.3); 0.805 (0.5); 0.801 (0.6); 0.795 (0.5); 0.790 (0.3); 0.774 (0.4); 0.765 (0.5); 0.743 (0.4); 0.718 (0.8); 0.706 (0.8); 0.703 (0.8); 0.695 (1.3); 0.689 (0.8); 0.681 (0.6); 0.672 (0.6); 0.000 (1.0)

    Example I-23

    [0397] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.932 (4.1); 7.918 (16.0); 7.674 (0.4); 7.521 (3.8); 7.505 (6.3); 7.464 (2.3); 7.450 (4.4); 7.434 (2.6); 7.419 (3.3); 7.417 (3.4); 7.402 (4.5); 7.389 (1.8); 7.004 (11.4); 6.932 (0.4); 6.399 (7.4); 6.310 (7.4); 6.300 (14.0); 4.712 (5.2); 4.682 (7.0); 4.510 (4.7); 4.482 (3.5); 4.481 (3.4); 3.317 (0.8); 2.506 (3.3); 2.502 (4.6); 2.499 (3.5); 2.073 (0.4); 0.858 (0.3); 0.542 (0.5); 0.532 (1.5); 0.520 (2.2); 0.510 (5.1); 0.505 (3.0); 0.493 (5.7); 0.484 (6.7); 0.478 (5.3); 0.470 (2.1); 0.468 (2.1); 0.462 (1.6); 0.449 (0.7); 0.308 (1.3); 0.296 (2.2); 0.290 (3.6); 0.286 (3.6); 0.272 (2.5); 0.263 (1.3); 0.000 (4.9)

    Example I-24

    [0398] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =8.428 (3.7); 8.097 (15.3); 7.882 (5.3); 7.880 (5.5); 7.872 (16.0); 7.867 (6.3); 7.864 (5.5); 7.523 (4.5); 7.508 (7.2); 7.467 (2.7); 7.452 (5.1); 7.437 (3.0); 7.422 (4.0); 7.421 (4.0); 7.407 (5.4); 7.392 (2.1); 6.735 (0.7); 6.446 (8.2); 6.357 (8.3); 4.861 (6.4); 4.831 (8.5); 4.665 (5.5); 4.637 (4.2); 3.172 (0.9); 2.507 (4.0); 2.503 (5.3); 2.500 (4.0); 0.427 (0.4); 0.417 (1.6); 0.399 (4.2); 0.390 (4.9); 0.383 (6.5); 0.372 (5.7); 0.367 (6.9); 0.361 (4.7); 0.346 (6.0); 0.340 (4.5); 0.329 (5.3); 0.321 (1.8); 0.311 (1.7); 0.301 (0.5); 0.000 (3.4)

    Example I-25

    [0399] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =8.330 (10.3); 8.327 (10.9); 8.321 (10.8); 8.318 (10.1); 8.174 (1.1); 7.982 (1.4); 7.929 (9.4); 7.927 (9.4); 7.914 (9.8); 7.842 (8.2); 7.276 (1.4); 7.260 (8.2); 7.250 (8.9); 7.245 (8.7); 7.235 (7.6); 7.001 (13.5); 6.939 (0.3); 4.465 (9.6); 4.436 (14.8); 4.340 (14.8); 4.311 (9.7); 4.294 (0.5); 4.276 (0.3); 4.249 (0.4); 4.220 (0.4); 4.079 (0.3); 4.066 (0.6); 4.052 (0.4); 4.037 (0.5); 3.417 (11.7); 3.389 (16.0); 3.270 (0.3); 3.247 (15.4); 3.218 (11.3); 2.957 (6.9); 2.870 (6.6); 2.670 (0.3); 1.459 (0.3); 1.441 (0.6); 1.427 (0.7); 1.256 (0.4); 0.856 (1.3); 0.845 (3.4); 0.839 (2.9); 0.830 (7.5); 0.823 (8.2); 0.818 (10.2); 0.809 (11.2); 0.797 (7.6); 0.787 (12.1); 0.778 (7.8); 0.765 (6.4); 0.757 (4.5); 0.744 (3.4); 0.733 (4.7); 0.723 (5.1); 0.718 (5.5); 0.715 (5.4); 0.709 (4.0); 0.705 (3.8); 0.699 (3.4); 0.688 (1.9); 0.000 (7.7)

    Example I-26

    [0400] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =8.340 (5.3); 8.337 (6.0); 8.331 (5.9); 8.327 (6.0); 8.040 (5.1); 8.037 (5.5); 8.025 (5.7); 8.022 (5.7); 7.943 (16.0); 7.812 (15.5); 7.434 (5.5); 7.425 (5.6); 7.419 (5.6); 7.409 (5.3); 5.753 (13.1); 5.512 (15.2); 4.652 (6.4); 4.622 (7.0); 4.029 (8.2); 4.000 (7.7); 3.436 (6.8); 3.407 (8.4); 3.315 (34.7); 3.196 (8.1); 3.167 (6.6); 2.506 (5.5); 2.502 (7.6); 2.499 (6.0); 0.954 (1.6); 0.940 (2.9); 0.933 (2.6); 0.928 (2.7); 0.919 (3.2); 0.906 (2.2); 0.753 (1.7); 0.739 (2.8); 0.732 (2.9); 0.727 (2.5); 0.717 (3.5); 0.705 (2.3); 0.598 (2.1); 0.587 (3.0); 0.584 (3.0); 0.577 (2.4); 0.572 (3.1); 0.566 (2.7); 0.563 (2.3); 0.551 (1.9); 0.498 (2.2); 0.487 (2.5); 0.484 (2.9); 0.477 (2.9); 0.473 (2.6); 0.466 (2.4); 0.462 (2.7); 0.451 (1.6); 0.000 (2.9)

    Example I-27

    [0401] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.741 (13.6); 7.528 (3.8); 7.512 (7.5); 7.496 (4.0); 7.364 (5.1); 7.361 (5.1); 7.345 (5.1); 7.341 (4.9); 7.245 (5.6); 7.241 (5.2); 7.228 (5.0); 7.225 (4.5); 6.952 (13.8); 5.750 (6.9); 5.274 (16.0); 4.375 (6.2); 4.346 (7.8); 4.138 (7.8); 4.109 (6.3); 3.303 (14.3); 3.152 (5.2); 3.124 (6.3); 2.901 (6.2); 2.873 (5.1); 2.501 (10.0); 1.236 (0.5); 0.726 (0.5); 0.710 (2.6); 0.705 (2.5); 0.701 (2.3); 0.696 (3.3); 0.684 (3.7); 0.679 (2.9); 0.648 (2.4); 0.639 (3.5); 0.636 (3.4); 0.626 (4.2); 0.616 (4.0); 0.596 (7.1); 0.583 (13.0); 0.571 (3.4); 0.550 (0.9); 0.000 (2.7)

    Example I-28

    [0402] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.628 (7.7); 7.543 (1.3); 7.529 (2.7); 7.515 (1.5); 7.290 (0.7); 7.276 (1.7); 7.262 (1.8); 7.248 (0.9); 7.061 (2.7); 7.047 (4.0); 7.034 (2.8); 7.019 (1.6); 6.756 (7.1); 6.124 (4.2); 6.048 (9.0); 6.034 (4.4); 4.543 (3.7); 4.513 (4.6); 4.248 (3.0); 4.220 (2.5); 3.108 (16.0); 2.295 (2.7); 2.292 (3.6); 2.289 (2.7); 1.778 (0.4); 0.233 (0.6); 0.222 (1.2); 0.219 (1.1); 0.211 (1.2); 0.207 (1.5); 0.200 (1.5); 0.197 (1.4); 0.185 (1.6); 0.182 (1.3); 0.166 (1.5); 0.160 (1.7); 0.155 (1.1); 0.146 (2.0); 0.135 (1.3); 0.080 (1.1); 0.069 (1.6); 0.059 (1.0); 0.054 (1.4); 0.049 (1.3); 0.033 (0.8); 0.014 (1.4); 0.003 (1.4); 0.000 (1.6); 0.007 (1.6); 0.011 (1.3); 0.018 (1.2); 0.022 (1.3); 0.033 (0.7); 0.21 1.4)

    Example I-29

    [0403] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.855 (6.9); 7.651 (7.3); 7.375 (1.8); 7.359 (3.8); 7.342 (2.2); 7.262 (5.2); 7.189 (2.3); 7.185 (3.0); 7.173 (1.8); 7.169 (3.2); 7.165 (3.5); 7.145 (2.5); 7.141 (2.3); 5.297 (16.0); 4.680 (3.8); 4.650 (4.3); 4.206 (4.2); 4.177 (3.7); 3.319 (2.2); 3.290 (3.2); 3.154 (3.3); 3.126 (2.3); 2.227 (2.1); 2.213 (2.1); 2.002 (0.9); 1.256 (1.4); 1.242 (0.5); 0.720 (0.6); 0.708 (0.9); 0.698 (1.6); 0.690 (1.9); 0.686 (2.1); 0.678 (2.3); 0.672 (2.1); 0.663 (2.5); 0.654 (1.7); 0.641 (1.0); 0.631 (1.1); 0.583 (1.1); 0.573 (1.0); 0.561 (1.7); 0.550 (2.5); 0.542 (1.7); 0.526 (1.8); 0.518 (1.9); 0.515 (2.0); 0.506 (1.8); 0.497 (0.9); 0.494 (0.9); 0.484 (0.7); 0.070 (1.6); 0.000 (5.4)

    Example I-30

    [0404] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.828 (13.6); 7.513 (3.6); 7.496 (7.4); 7.480 (4.1); 7.357 (4.4); 7.353 (4.7); 7.338 (4.4); 7.334 (4.7); 7.237 (5.0); 7.233 (4.9); 7.220 (4.5); 7.216 (4.5); 6.993 (13.1); 5.272 (16.0); 4.352 (5.6); 4.323 (8.3); 4.217 (8.4); 4.188 (5.8); 3.328 (12.3); 3.163 (5.1); 3.134 (5.9); 2.821 (5.8); 2.793 (5.0); 2.509 (2.5); 2.506 (3.4); 2.502 (2.6); 0.741 (0.7); 0.734 (0.7); 0.731 (0.7); 0.709 (13.7); 0.688 (1.6); 0.681 (1.7); 0.675 (1.0); 0.645 (2.2); 0.623 (8.5); 0.601 (6.0); 0.596 (5.1); 0.581 (1.4); 0.576 (1.4); 0.571 (1.2); 0.000 (1.5)

    Example I-31

    [0405] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.827 (10.4); 7.662 (0.6); 7.639 (10.3); 7.563 (0.4); 7.486 (1.7); 7.471 (3.3); 7.458 (1.7); 7.272 (0.9); 7.258 (2.0); 7.244 (2.1); 7.230 (1.1); 7.043 (3.6); 7.029 (5.0); 7.020 (3.3); 7.015 (3.1); 7.002 (2.0); 6.153 (16.0); 6.063 (5.5); 4.640 (4.8); 4.610 (6.1); 4.401 (3.8); 4.373 (3.0); 4.371 (3.0); 3.805 (0.5); 3.791 (0.5); 3.089 (4.1); 2.274 (1.9); 2.271 (2.7); 2.267 (2.0); 1.756 (2.0); 1.001 (0.4); 0.957 (0.6); 0.943 (1.1); 0.928 (0.6); 0.147 (0.7); 0.136 (1.1); 0.126 (1.5); 0.121 (1.7); 0.116 (1.8); 0.110 (1.8); 0.102 (1.7); 0.085 (1.0); 0.072 (1.7); 0.063 (2.1); 0.050 (2.6); 0.042 (5.5); 0.033 (2.6); 0.020 (2.1); 0.013 (2.3); 0.000 (2.5); 0.008 (1.8); 0.013 (2.1); 0.019 (1.7); 0.023 (1.5); 0.034 (1.2); 0.045 (0.6); 0.234 (1.8)

    Example I-32

    [0406] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.741 (11.9); 7.594 (0.3); 7.592 (0.4); 7.523 (2.4); 7.511 (4.3); 7.508 (4.6); 7.495 (2.5); 7.493 (2.4); 7.317 (1.1); 7.314 (1.2); 7.302 (2.8); 7.287 (3.1); 7.276 (1.6); 7.273 (1.5); 7.232 (0.4); 7.230 (0.4); 7.160 (3.6); 7.149 (4.3); 7.142 (4.9); 7.135 (7.3); 7.121 (4.6); 6.948 (11.7); 5.754 (0.4); 5.226 (16.0); 4.397 (6.1); 4.368 (7.4); 4.088 (7.6); 4.058 (6.5); 3.331 (1.1); 3.128 (4.2); 3.100 (6.4); 3.007 (6.5); 2.979 (4.2); 2.507 (2.6); 2.504 (3.5); 2.500 (2.7); 0.755 (0.5); 0.737 (2.6); 0.727 (3.1); 0.716 (3.1); 0.710 (2.3); 0.631 (1.1); 0.622 (2.3); 0.617 (2.4); 0.608 (3.8); 0.604 (2.5); 0.597 (3.1); 0.584 (5.3); 0.580 (4.8); 0.572 (13.9); 0.559 (3.1); 0.553 (1.0); 0.539 (0.7); 0.000 (1.9)

    Example I-33

    [0407] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.824 (13.1); 7.510 (2.3); 7.507 (2.4); 7.495 (4.4); 7.492 (4.6); 7.479 (2.5); 7.477 (2.4); 7.311 (1.1); 7.308 (1.2); 7.296 (2.8); 7.281 (3.3); 7.269 (1.6); 7.267 (1.5); 7.153 (3.6); 7.140 (4.7); 7.134 (5.0); 7.127 (7.2); 7.113 (4.1); 6.984 (12.7); 5.205 (16.0); 4.373 (6.0); 4.344 (7.8); 4.164 (8.1); 4.135 (6.4); 3.323 (1.9); 3.139 (4.8); 3.111 (6.1); 2.927 (6.2); 2.899 (4.8); 2.507 (3.1); 2.503 (4.1); 2.500 (3.1); 0.755 (0.6); 0.746 (1.4); 0.742 (1.5); 0.734 (2.6); 0.726 (2.8); 0.721 (3.7); 0.717 (3.5); 0.707 (3.9); 0.701 (3.9); 0.700 (3.9); 0.689 (3.3); 0.678 (2.0); 0.668 (0.9); 0.661 (0.3); 0.648 (0.4); 0.641 (0.4); 0.631 (1.3); 0.626 (1.3); 0.623 (1.2); 0.615 (3.3); 0.602 (5.3); 0.597 (3.5); 0.591 (3.2); 0.587 (4.6); 0.583 (3.4); 0.575 (2.7); 0.567 (1.3); 0.562 (1.2); 0.559 (1.0); 0.549 (0.3); 0.000 (1.8)

    Example I-34

    [0408] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.951 (16.0); 7.815 (15.2); 7.552 (2.6); 7.539 (4.8); 7.536 (5.1); 7.523 (2.7); 7.521 (2.7); 7.339 (1.2); 7.336 (1.3); 7.324 (3.1); 7.313 (3.0); 7.309 (3.5); 7.298 (1.9); 7.295 (1.7); 7.188 (3.8); 7.173 (7.7); 7.159 (7.5); 7.153 (3.7); 7.145 (3.5); 7.110 (0.3); 5.430 (15.9); 4.585 (6.5); 4.555 (7.2); 4.069 (8.0); 4.040 (7.3); 3.320 (5.6); 3.222 (4.9); 3.194 (7.2); 3.085 (6.7); 3.057 (4.5); 2.507 (2.9); 2.503 (4.0); 2.500 (3.1); 2.074 (3.3); 0.885 (0.5); 0.818 (1.6); 0.804 (2.8); 0.796 (2.6); 0.791 (2.7); 0.782 (3.1); 0.770 (2.3); 0.631 (1.6); 0.617 (2.7); 0.610 (2.9); 0.605 (2.3); 0.596 (3.4); 0.584 (2.4); 0.501 (2.2); 0.490 (3.1); 0.487 (2.9); 0.480 (2.2); 0.475 (3.1); 0.469 (2.6); 0.466 (2.1); 0.454 (1.9); 0.426 (2.4); 0.415 (2.5); 0.412 (2.9); 0.405 (3.0); 0.401 (2.5); 0.394 (2.4); 0.390 (2.6); 0.379 (1.5); 0.000 (1.8)

    Example I-35

    [0409] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.488 (0.7); 7.475 (1.3); 7.473 (1.4); 7.460 (0.7); 7.458 (0.7); 7.293 (0.3); 7.281 (0.8); 7.266 (1.0); 7.255 (0.5); 7.252 (0.5); 7.234 (3.7); 7.136 (1.1); 7.126 (1.3); 7.118 (1.5); 7.112 (2.3); 7.098 (1.6); 6.228 (3.7); 5.036 (3.7); 4.181 (1.8); 4.152 (2.3); 3.944 (2.3); 3.915 (1.9); 3.784 (16.0); 3.324 (0.6); 3.094 (1.4); 3.066 (1.9); 2.917 (1.9); 2.889 (1.4); 2.502 (1.4); 2.499 (1.1); 0.650 (3.8); 0.634 (0.4); 0.630 (0.4); 0.626 (0.4); 0.561 (0.6); 0.536 (2.0); 0.515 (1.9); 0.499 (0.5); 0.495 (0.4); 0.492 (0.4); 0.000 (0.6)

    Example I-36

    [0410] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.797 (11.6); 7.662 (0.5); 7.629 (1.2); 7.542 (2.3); 7.529 (4.0); 7.526 (4.5); 7.513 (2.3); 7.511 (2.4); 7.494 (0.7); 7.468 (1.2); 7.384 (0.3); 7.381 (0.3); 7.370 (0.5); 7.367 (0.5); 7.358 (1.3); 7.354 (1.5); 7.343 (2.6); 7.327 (3.4); 7.321 (12.2); 7.263 (0.5); 7.248 (0.4); 7.230 (0.6); 7.222 (0.6); 7.209 (1.1); 7.195 (3.6); 7.185 (4.0); 7.177 (4.4); 7.171 (6.6); 7.157 (4.3); 5.332 (1.5); 5.242 (13.2); 4.886 (0.4); 4.677 (16.0); 4.531 (0.6); 4.502 (0.7); 4.453 (4.7); 4.424 (7.1); 4.332 (0.6); 4.322 (7.2); 4.293 (4.9); 4.262 (0.4); 4.040 (0.8); 4.004 (0.7); 3.992 (1.8); 3.975 (0.6); 3.373 (12.7); 3.218 (4.3); 3.190 (5.1); 3.167 (0.3); 3.139 (0.8); 3.114 (0.8); 2.924 (5.3); 2.896 (4.3); 2.562 (5.6); 2.559 (7.7); 2.556 (5.9); 1.057 (0.4); 0.804 (0.8); 0.796 (0.8); 0.791 (1.3); 0.776 (3.1); 0.766 (5.4); 0.762 (4.6); 0.743 (1.5); 0.738 (1.3); 0.730 (1.6); 0.711 (0.4); 0.688 (0.4); 0.676 (1.7); 0.669 (1.2); 0.655 (2.3); 0.644 (4.3); 0.628 (4.0); 0.624 (3.6); 0.616 (2.0); 0.607 (1.4); 0.603 (1.4); 0.595 (1.2); 0.588 (0.5); 0.458 (0.4); 0.450 (0.4); 0.443 (0.4); 0.439 (0.5); 0.435 (0.5); 0.429 (0.4); 0.423 (0.3)

    Example I-37

    [0411] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.539 (10.7); 7.523 (4.1); 7.508 (2.1); 7.315 (0.9); 7.303 (2.3); 7.288 (2.6); 7.277 (1.4); 7.274 (1.3); 7.170 (2.8); 7.152 (6.6); 7.138 (5.9); 7.123 (2.6); 6.509 (8.4); 5.099 (11.1); 4.409 (4.5); 4.380 (5.5); 4.111 (5.6); 4.082 (4.8); 3.323 (1.4); 3.081 (16.0); 2.502 (4.1); 2.073 (2.8); 1.820 (0.6); 1.809 (1.4); 1.803 (1.6); 1.793 (2.8); 1.783 (1.8); 1.777 (1.6); 1.767 (0.8); 1.337 (0.4); 0.818 (0.8); 0.805 (2.9); 0.800 (3.6); 0.792 (4.7); 0.781 (4.4); 0.772 (3.1); 0.764 (1.3); 0.711 (1.0); 0.703 (1.2); 0.700 (1.4); 0.693 (2.2); 0.683 (2.1); 0.675 (2.2); 0.670 (1.0); 0.665 (1.1); 0.657 (1.5); 0.647 (1.8); 0.642 (1.9); 0.633 (4.4); 0.614 (4.6); 0.598 (9.0); 0.582 (2.1); 0.570 (0.5); 0.563 (0.8); 0.537 (0.8); 0.526 (1.6); 0.518 (2.5); 0.508 (2.8); 0.500 (2.1); 0.489 (1.0); 0.434 (1.1); 0.424 (2.1); 0.416 (2.7); 0.405 (2.5); 0.397 (1.5); 0.387 (0.8); 0.000 (1.0)

    Example I-38

    [0412] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.712 (13.6); 7.604 (4.0); 7.600 (4.3); 7.590 (3.9); 7.586 (4.8); 7.418 (4.0); 7.415 (3.6); 7.404 (4.8); 7.400 (5.4); 7.389 (0.4); 7.296 (1.7); 7.284 (4.7); 7.281 (5.0); 7.275 (5.0); 7.270 (8.5); 7.260 (4.9); 7.252 (13.7); 7.242 (1.6); 5.753 (2.3); 5.143 (13.6); 4.583 (16.0); 4.453 (5.9); 4.424 (7.0); 4.137 (7.4); 4.108 (6.4); 3.322 (7.1); 3.235 (3.3); 3.206 (9.8); 3.182 (9.5); 3.154 (3.2); 2.503 (4.2); 2.074 (0.5); 0.927 (1.4); 0.914 (2.1); 0.904 (3.4); 0.897 (2.4); 0.893 (2.6); 0.884 (2.1); 0.782 (1.6); 0.772 (2.8); 0.764 (3.4); 0.751 (2.1); 0.742 (2.4); 0.719 (2.0); 0.710 (1.5); 0.699 (3.2); 0.687 (3.8); 0.677 (3.7); 0.674 (4.0); 0.666 (3.1); 0.661 (2.9); 0.652 (2.8); 0.645 (1.3); 0.641 (1.3); 0.632 (1.0); 0.000 (1.1)

    Example I-39

    [0413] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.157 (0.4); 7.760 (12.3); 7.395 (8.1); 7.373 (12.7); 7.319 (6.1); 7.297 (12.0); 7.272 (11.5); 7.243 (4.4); 7.220 (1.3); 6.981 (12.1); 5.798 (0.6); 5.779 (1.4); 5.257 (16.0); 4.516 (0.8); 4.395 (5.4); 4.372 (0.7); 4.347 (8.3); 4.181 (8.2); 4.132 (5.4); 3.346 (23.0); 3.193 (5.8); 3.147 (7.2); 2.816 (6.9); 2.770 (5.6); 2.525 (15.7); 1.317 (0.5); 1.293 (0.4); 1.258 (0.4); 0.617 (1.7); 0.582 (4.7); 0.571 (7.1); 0.554 (8.0); 0.536 (13.1); 0.513 (3.7); 0.499 (2.7); 0.478 (1.5); 0.456 (2.3); 0.438 (3.7); 0.421 (3.5); 0.396 (2.2); 0.379 (1.2); 0.023 (12.2)

    Example I-40

    [0414] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.892 (14.7); 7.731 (0.3); 7.682 (15.1); 7.662 (0.5); 7.648 (6.0); 7.644 (6.2); 7.621 (7.2); 7.617 (7.2); 7.600 (2.3); 7.552 (4.9); 7.547 (5.3); 7.527 (6.9); 7.521 (7.0); 7.409 (3.4); 7.405 (3.5); 7.384 (6.7); 7.380 (6.6); 7.359 (3.8); 7.355 (3.5); 7.298 (16.2); 7.265 (4.1); 7.259 (4.4); 7.239 (5.5); 7.234 (5.8); 7.214 (2.7); 7.208 (2.8); 7.146 (0.7); 7.116 (0.5); 5.486 (0.8); 4.760 (9.4); 4.711 (11.3); 4.696 (1.1); 4.651 (1.2); 4.377 (0.8); 4.332 (0.6); 4.263 (11.0); 4.215 (9.2); 4.190 (0.4); 4.166 (1.0); 4.142 (1.0); 4.119 (0.3); 3.825 (0.4); 3.538 (2.4); 3.490 (15.1); 3.473 (16.0); 3.425 (2.6); 3.395 (1.2); 3.346 (1.1); 2.488 (12.9); 2.078 (4.3); 2.041 (12.4); 1.696 (12.8); 1.603 (0.3); 1.316 (1.1); 1.292 (2.3); 1.269 (1.2); 1.166 (0.4); 1.149 (0.5); 1.128 (0.9); 1.106 (0.4); 1.058 (0.3); 1.031 (0.6); 1.024 (0.4); 1.016 (0.4); 1.006 (0.4); 0.990 (0.4); 0.879 (0.7); 0.850 (2.2); 0.840 (2.8); 0.832 (3.3); 0.827 (2.4); 0.808 (3.9); 0.804 (3.1); 0.796 (4.0); 0.762 (0.8); 0.752 (3.0); 0.740 (2.5); 0.732 (4.6); 0.718 (5.6); 0.713 (4.9); 0.705 (4.4); 0.700 (5.1); 0.693 (5.0); 0.687 (5.1); 0.673 (4.9); 0.666 (2.6); 0.653 (3.9); 0.620 (4.2); 0.612 (3.5); 0.609 (4.2); 0.589 (2.7); 0.586 (3.3); 0.576 (2.7); 0.571 (1.6); 0.566 (2.2); 0.537 (0.7); 0.044 (0.5); 0.033 (15.3); 0.022 (0.6)

    Example I-41

    [0415] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.868 (6.3); 7.659 (5.2); 7.605 (5.1); 7.468 (0.8); 7.465 (0.8); 7.430 (9.9); 7.403 (1.4); 7.300 (2.1); 4.731 (3.9); 4.682 (4.7); 4.232 (3.1); 4.183 (2.6); 3.389 (16.0); 2.987 (1.3); 2.891 (0.8); 2.677 (1.1); 2.661 (1.5); 2.033 (3.1); 0.853 (0.3); 0.823 (1.2); 0.814 (1.3); 0.805 (1.9); 0.800 (1.5); 0.782 (2.0); 0.778 (1.8); 0.770 (2.1); 0.733 (1.3); 0.713 (1.8); 0.695 (3.2); 0.688 (2.6); 0.680 (2.4); 0.670 (3.4); 0.655 (2.0); 0.649 (1.5); 0.635 (1.3); 0.588 (1.4); 0.577 (1.9); 0.552 (1.8); 0.544 (1.6); 0.534 (1.1); 0.024 (1.0)

    Example I-42

    [0416] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.977 (0.5); 7.886 (8.8); 7.690 (4.6); 7.677 (5.5); 7.597 (0.4); 7.588 (0.4); 7.381 (0.8); 7.373 (0.9); 7.352 (16.0); 7.333 (8.0); 7.321 (3.3); 7.314 (3.4); 7.306 (3.0); 7.300 (10.2); 7.099 (0.4); 7.072 (0.4); 4.930 (1.2); 4.873 (0.4); 4.823 (0.5); 4.724 (5.7); 4.675 (7.0); 4.560 (0.5); 4.511 (0.4); 4.247 (5.3); 4.198 (4.4); 3.353 (2.8); 3.305 (4.9); 3.188 (7.1); 3.140 (4.0); 2.458 (0.7); 2.437 (0.7); 2.268 (0.9); 2.244 (0.7); 2.042 (1.6); 1.673 (0.5); 1.021 (0.3); 0.921 (0.4); 0.754 (0.9); 0.747 (1.7); 0.726 (4.3); 0.711 (4.4); 0.702 (5.5); 0.698 (5.2); 0.675 (1.7); 0.663 (1.1); 0.653 (1.8); 0.646 (1.9); 0.626 (2.5); 0.623 (2.5); 0.613 (1.1); 0.605 (0.5); 0.595 (2.2); 0.592 (2.4); 0.577 (4.6); 0.573 (4.7); 0.553 (4.2); 0.539 (2.6); 0.526 (2.2); 0.512 (1.1); 0.505 (1.0); 0.495 (1.2); 0.104 (0.3); 0.034 (4.9)

    Example I-43

    [0417] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.765 (6.1); 7.601 (6.7); 7.448 (16.0); 7.444 (15.3); 7.300 (50.8); 7.021 (6.9); 5.339 (3.6); 4.471 (3.9); 4.422 (7.1); 4.317 (7.0); 4.267 (3.8); 3.402 (3.4); 3.354 (7.2); 3.274 (7.5); 3.226 (3.6); 2.358 (0.5); 2.154 (3.2); 2.128 (0.6); 2.085 (0.4); 1.633 (3.1); 1.322 (0.4); 1.292 (4.0); 1.261 (0.4); 0.888 (0.7); 0.865 (1.6); 0.842 (5.5); 0.838 (5.0); 0.831 (3.3); 0.820 (5.9); 0.811 (1.6); 0.802 (2.0); 0.786 (2.7); 0.779 (2.0); 0.776 (1.9); 0.755 (0.5); 0.738 (0.5); 0.718 (3.2); 0.703 (1.4); 0.698 (2.0); 0.687 (1.0); 0.675 (1.1); 0.049 (1.7); 0.038 (49.4); 0.028 (1.7)

    Example I-44

    [0418] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.722 (14.8); 7.719 (16.0); 7.391 (3.6); 7.377 (1.1); 7.362 (8.5); 7.338 (8.5); 7.318 (8.5); 7.312 (13.6); 7.305 (9.2); 7.300 (12.0); 7.289 (4.7); 7.285 (4.1); 7.272 (7.3); 7.267 (5.5); 6.940 (12.8); 6.937 (14.2); 4.446 (7.8); 4.397 (15.7); 4.312 (15.1); 4.263 (7.6); 3.322 (5.4); 3.318 (5.6); 3.274 (7.3); 3.271 (7.8); 3.040 (8.0); 3.037 (8.1); 2.993 (6.1); 2.990 (6.2); 2.075 (0.6); 2.037 (1.8); 0.826 (2.5); 0.812 (3.5); 0.794 (6.5); 0.789 (6.9); 0.778 (8.1); 0.761 (11.4); 0.750 (9.6); 0.736 (7.4); 0.715 (5.6); 0.704 (7.0); 0.693 (2.8); 0.688 (3.8); 0.682 (3.7); 0.676 (4.2); 0.659 (2.4); 0.657 (2.3); 0.644 (2.1); 0.626 (0.9); 0.032 (5.8)

    Example I-45

    [0419] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =7.977 (4.5); 7.975 (4.5); 7.862 (4.6); 7.860 (4.3); 7.631 (2.9); 7.483 (1.3); 7.457 (1.7); 7.434 (1.4); 7.408 (2.0); 7.312 (2.5); 7.286 (3.3); 7.260 (1.2); 5.776 (16.0); 5.557 (5.7); 5.451 (0.5); 4.594 (2.0); 4.545 (2.4); 4.184 (2.4); 4.135 (2.0); 4.061 (0.6); 4.037 (0.6); 3.343 (87.6); 3.194 (1.6); 3.148 (2.4); 2.994 (2.3); 2.948 (1.5); 2.653 (0.4); 2.620 (0.4); 2.533 (2.8); 2.527 (5.8); 2.521 (7.9); 2.515 (5.8); 2.510 (2.8); 2.094 (0.5); 2.008 (2.7); 1.218 (0.7); 1.194 (1.5); 1.171 (0.7); 0.572 (0.5); 0.566 (0.5); 0.557 (0.7); 0.541 (0.7); 0.529 (1.5); 0.505 (0.8); 0.496 (0.9); 0.479 (2.0); 0.474 (2.4); 0.468 (2.5); 0.460 (2.4); 0.446 (1.0); 0.435 (0.9); 0.414 (1.4); 0.402 (0.8); 0.385 (0.8); 0.370 (0.5); 0.020 (5.3)

    Example I-46

    [0420] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.765 (15.1); 8.753 (4.7); 8.545 (8.1); 8.529 (9.9); 8.515 (2.6); 7.887 (16.0); 7.699 (13.4); 7.691 (4.9); 7.646 (0.4); 7.551 (12.1); 7.535 (11.8); 7.300 (19.5); 5.334 (2.7); 4.751 (10.8); 4.702 (13.2); 4.307 (8.7); 4.297 (3.1); 4.258 (7.2); 4.249 (2.5); 3.555 (5.0); 3.546 (1.9); 3.508 (9.5); 3.499 (3.9); 3.411 (10.1); 3.364 (5.3); 2.993 (0.5); 2.791 (0.5); 2.716 (0.5); 2.600 (5.1); 2.042 (5.0); 1.887 (0.9); 1.771 (6.2); 1.284 (0.6); 0.875 (1.9); 0.863 (2.2); 0.856 (2.4); 0.843 (4.4); 0.832 (3.5); 0.821 (4.7); 0.809 (5.5); 0.783 (4.4); 0.772 (4.6); 0.767 (5.9); 0.753 (4.6); 0.741 (1.2); 0.732 (2.8); 0.720 (4.9); 0.710 (1.6); 0.698 (3.2); 0.685 (2.2); 0.680 (1.8); 0.663 (3.9); 0.649 (4.7); 0.646 (4.3); 0.634 (3.6); 0.623 (5.9); 0.612 (5.1); 0.601 (3.7); 0.592 (5.0); 0.577 (2.6); 0.569 (2.3); 0.557 (1.8); 0.102 (1.0); 0.042 (0.5); 0.031 (14.8); 0.020 (0.7)

    Example I-47

    [0421] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.513 (15.9); 7.869 (12.0); 7.738 (16.0); 7.683 (12.1); 7.681 (11.8); 7.653 (0.4); 7.300 (4.6); 4.750 (6.4); 4.701 (7.8); 4.582 (0.4); 4.448 (0.4); 4.292 (7.9); 4.243 (6.6); 4.153 (0.5); 4.129 (0.5); 3.510 (4.5); 3.463 (8.6); 3.427 (0.4); 3.375 (9.7); 3.328 (5.0); 2.921 (15.9); 2.072 (2.0); 1.941 (5.3); 1.310 (0.6); 1.286 (1.2); 1.262 (0.6); 1.139 (0.3); 0.947 (0.5); 0.915 (2.4); 0.908 (1.9); 0.899 (2.8); 0.892 (2.0); 0.875 (2.6); 0.868 (1.9); 0.859 (2.8); 0.804 (2.0); 0.788 (2.0); 0.782 (3.0); 0.766 (3.4); 0.758 (0.9); 0.749 (5.4); 0.741 (5.5); 0.724 (3.7); 0.707 (2.9); 0.701 (2.1); 0.685 (1.9); 0.623 (2.7); 0.614 (1.8); 0.608 (2.5); 0.589 (2.0); 0.583 (2.9); 0.573 (1.8); 0.566 (2.3); 0.534 (0.5); 0.097 (1.5); 0.025 (3.1)

    Example I-48

    [0422] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.282 (1.7); 8.267 (6.1); 8.251 (5.0); 7.847 (9.1); 7.635 (2.5); 7.618 (7.4); 7.600 (0.4); 7.512 (10.3); 7.496 (10.0); 7.300 (2.6); 5.483 (0.6); 4.724 (4.9); 4.675 (5.9); 4.252 (4.2); 4.203 (3.5); 4.148 (0.7); 4.132 (0.9); 4.124 (1.9); 4.108 (0.9); 4.100 (1.9); 4.076 (0.7); 3.606 (0.6); 3.596 (0.5); 3.544 (16.0); 3.496 (1.2); 3.393 (3.6); 3.328 (0.5); 2.373 (0.4); 2.053 (4.1); 2.047 (8.5); 1.503 (1.3); 1.287 (3.9); 1.270 (6.4); 1.264 (7.4); 1.246 (1.7); 1.240 (2.6); 0.908 (1.6); 0.899 (2.2); 0.887 (3.9); 0.864 (3.8); 0.857 (2.8); 0.845 (3.1); 0.840 (3.4); 0.813 (2.8); 0.794 (1.9); 0.781 (2.5); 0.775 (2.8); 0.754 (8.3); 0.731 (2.6); 0.714 (1.8); 0.692 (0.9); 0.630 (1.4); 0.604 (2.6); 0.599 (2.7); 0.586 (2.5); 0.580 (2.1); 0.562 (1.8); 0.544 (0.8); 0.013 (0.6); 0.007 (0.8)

    Example I-49

    [0423] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.861 (15.8); 7.631 (13.3); 7.478 (7.3); 7.470 (8.6); 7.452 (10.1); 7.444 (12.2); 7.301 (2.8); 7.276 (6.5); 7.250 (9.8); 7.224 (4.1); 4.750 (8.5); 4.702 (10.1); 4.206 (9.2); 4.157 (7.8); 3.562 (4.9); 3.514 (15.1); 3.474 (11.9); 3.426 (3.8); 2.836 (1.4); 2.806 (2.9); 2.791 (2.9); 2.043 (0.4); 2.027 (16.0); 0.851 (1.4); 0.836 (2.6); 0.819 (3.2); 0.812 (4.0); 0.804 (3.8); 0.794 (4.9); 0.778 (0.8); 0.767 (3.1); 0.744 (1.7); 0.722 (4.2); 0.707 (10.5); 0.689 (8.1); 0.685 (9.6); 0.671 (3.6); 0.663 (2.6); 0.649 (1.5); 0.599 (2.2); 0.573 (4.1); 0.563 (3.7); 0.555 (4.4); 0.550 (3.7); 0.530 (2.8); 0.517 (1.4); 0.020 (1.9)

    Example I-50

    [0424] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.313 (5.9); 8.297 (6.2); 7.877 (10.0); 7.680 (9.7); 7.616 (0.4); 7.509 (6.2); 7.493 (5.9); 7.302 (3.8); 7.300 (3.2); 4.756 (4.8); 4.707 (5.8); 4.286 (5.8); 4.237 (4.8); 4.155 (0.4); 4.131 (0.4); 3.559 (2.0); 3.513 (8.3); 3.488 (8.3); 3.442 (1.9); 2.776 (3.0); 2.072 (1.6); 2.042 (16.0); 1.843 (0.8); 1.312 (0.4); 1.288 (0.9); 1.264 (0.4); 0.865 (1.5); 0.857 (1.3); 0.843 (2.6); 0.822 (2.0); 0.809 (2.8); 0.784 (1.9); 0.765 (2.8); 0.749 (2.7); 0.729 (3.6); 0.718 (3.6); 0.697 (2.4); 0.679 (2.4); 0.663 (1.6); 0.609 (2.3); 0.597 (2.0); 0.574 (2.9); 0.562 (1.4); 0.553 (1.7); 0.029 (3.5)

    Example I-51

    [0425] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.891 (5.0); 7.677 (4.7); 7.675 (4.8); 7.300 (3.9); 7.201 (2.0); 7.176 (2.9); 7.152 (0.5); 7.144 (0.6); 7.078 (4.7); 7.049 (1.4); 4.698 (2.8); 4.650 (3.5); 4.279 (3.4); 4.259 (0.3); 4.231 (2.7); 3.454 (2.4); 3.407 (2.9); 3.051 (3.0); 3.004 (2.4); 2.397 (0.4); 2.376 (0.4); 2.347 (15.1); 2.295 (16.0); 2.082 (0.4); 2.072 (0.4); 2.016 (0.5); 1.939 (0.3); 1.911 (0.3); 0.925 (0.6); 0.917 (0.8); 0.911 (0.8); 0.897 (1.3); 0.893 (1.5); 0.876 (1.1); 0.862 (1.3); 0.756 (1.1); 0.744 (1.0); 0.738 (1.3); 0.725 (1.5); 0.703 (1.2); 0.698 (1.7); 0.690 (1.7); 0.683 (1.0); 0.665 (1.5); 0.647 (1.7); 0.629 (1.4); 0.615 (2.0); 0.603 (1.3); 0.580 (1.4); 0.569 (0.6); 0.560 (0.7); 0.555 (0.5); 0.037 (3.5)

    Example I-52

    [0426] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.884 (11.5); 7.683 (11.5); 7.666 (0.6); 7.617 (1.3); 7.505 (7.3); 7.477 (16.0); 7.469 (8.5); 7.375 (0.6); 7.335 (5.3); 7.328 (4.7); 7.307 (4.0); 7.300 (11.4); 7.210 (0.6); 7.203 (0.6); 7.182 (0.4); 7.175 (0.4); 7.138 (0.4); 5.333 (2.5); 4.740 (7.0); 4.691 (8.4); 4.571 (0.4); 4.398 (0.5); 4.252 (7.2); 4.204 (6.0); 3.464 (1.8); 3.416 (10.9); 3.400 (12.7); 3.352 (2.9); 3.304 (0.8); 2.502 (3.2); 2.498 (3.2); 2.473 (1.8); 1.765 (0.8); 1.742 (0.5); 1.119 (0.6); 1.100 (0.5); 1.022 (0.5); 1.006 (0.4); 0.832 (1.2); 0.828 (1.6); 0.820 (1.7); 0.810 (2.7); 0.805 (2.2); 0.786 (3.1); 0.773 (4.5); 0.745 (2.7); 0.733 (2.7); 0.727 (3.3); 0.711 (3.1); 0.692 (2.6); 0.689 (4.1); 0.679 (4.1); 0.674 (2.5); 0.662 (1.6); 0.653 (3.1); 0.640 (3.6); 0.635 (3.3); 0.622 (3.1); 0.600 (4.5); 0.588 (3.0); 0.568 (3.8); 0.558 (1.0); 0.554 (1.6); 0.545 (1.5); 0.541 (1.4); 0.032 (7.1)

    Example I-53

    [0427] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.885 (13.4); 7.662 (10.7); 7.599 (0.8); 7.486 (8.0); 7.458 (8.9); 7.389 (1.4); 7.378 (13.0); 7.371 (4.4); 7.355 (5.7); 7.349 (15.0); 7.337 (2.2); 7.300 (3.2); 7.060 (8.7); 7.051 (9.9); 7.028 (1.9); 7.017 (16.0); 7.009 (4.8); 6.994 (5.2); 6.987 (13.5); 6.975 (6.7); 6.966 (4.6); 6.947 (5.2); 6.938 (4.3); 4.755 (7.1); 4.706 (8.4); 4.562 (0.4); 4.455 (0.6); 4.410 (0.3); 4.221 (7.1); 4.172 (6.0); 3.457 (1.7); 3.409 (10.9); 3.393 (10.9); 3.344 (1.8); 3.307 (0.4); 3.258 (0.3); 2.579 (2.7); 2.528 (0.9); 2.033 (2.9); 1.913 (0.4); 0.864 (0.9); 0.849 (1.8); 0.831 (2.7); 0.825 (2.9); 0.817 (2.8); 0.807 (3.5); 0.792 (0.7); 0.780 (2.3); 0.766 (1.2); 0.752 (2.3); 0.744 (2.8); 0.729 (8.1); 0.712 (5.6); 0.707 (6.6); 0.694 (2.8); 0.686 (1.5); 0.672 (1.1); 0.622 (1.7); 0.612 (0.7); 0.596 (3.3); 0.585 (2.7); 0.578 (3.2); 0.573 (2.6); 0.553 (2.2); 0.540 (1.0); 0.029 (2.7)

    Example I-54

    [0428] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.042 (0.3); 8.039 (0.3); 7.958 (4.6); 7.893 (0.4); 7.837 (4.5); 7.479 (1.1); 7.465 (1.3); 7.463 (1.4); 7.451 (1.3); 7.208 (0.4); 7.191 (1.0); 7.169 (6.6); 7.159 (3.3); 7.150 (2.4); 7.138 (1.8); 5.677 (0.8); 5.570 (0.4); 5.237 (4.5); 5.204 (0.4); 4.567 (1.7); 4.553 (0.4); 4.519 (2.1); 4.060 (2.7); 4.011 (2.2); 3.359 (6.0); 3.214 (1.6); 3.166 (2.9); 3.139 (0.3); 3.076 (2.7); 3.028 (1.4); 2.533 (3.9); 2.527 (8.2); 2.521 (11.1); 2.515 (8.0); 2.509 (3.8); 2.340 (1.3); 2.318 (16.0); 2.249 (0.6); 2.009 (0.8); 1.195 (0.4); 0.959 (0.4); 0.938 (0.8); 0.934 (0.8); 0.923 (0.8); 0.914 (0.8); 0.903 (0.9); 0.899 (0.9); 0.879 (0.7); 0.761 (0.5); 0.736 (0.8); 0.726 (0.9); 0.716 (0.7); 0.707 (0.8); 0.701 (1.1); 0.682 (0.8); 0.604 (0.6); 0.587 (1.0); 0.570 (0.5); 0.562 (1.1); 0.550 (1.4); 0.525 (1.2); 0.514 (1.0); 0.506 (0.7); 0.495 (0.7); 0.489 (0.8); 0.471 (0.4); 0.031 (0.5); 0.020 (13.0); 0.009 (0.5)

    Example I-55

    [0429] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =7.916 (3.6); 7.914 (3.6); 7.802 (3.8); 7.799 (3.6); 7.440 (1.2); 7.435 (1.3); 7.416 (1.4); 7.410 (1.4); 7.315 (0.6); 7.310 (0.6); 7.288 (1.2); 7.263 (0.9); 7.258 (0.8); 7.049 (1.8); 7.024 (1.4); 6.975 (1.0); 6.972 (0.9); 6.951 (1.7); 6.947 (1.6); 6.926 (0.8); 6.922 (0.7); 5.138 (3.0); 5.136 (3.0); 4.640 (1.2); 4.591 (1.4); 4.084 (1.0); 4.061 (3.1); 4.037 (3.1); 4.013 (1.0); 3.896 (2.0); 3.847 (2.6); 3.838 (16.0); 3.528 (1.6); 3.481 (1.8); 3.340 (8.9); 2.866 (1.7); 2.820 (1.5); 2.533 (1.5); 2.527 (3.2); 2.521 (4.3); 2.515 (3.1); 2.509 (1.5); 2.009 (13.8); 1.218 (3.8); 1.194 (7.5); 1.171 (3.7); 1.004 (0.4); 0.980 (0.6); 0.968 (0.6); 0.960 (0.6); 0.948 (0.7); 0.925 (0.5); 0.727 (0.4); 0.702 (0.6); 0.692 (0.7); 0.683 (0.5); 0.672 (0.7); 0.667 (0.8); 0.648 (0.6); 0.541 (0.5); 0.523 (0.7); 0.518 (0.6); 0.506 (0.5); 0.499 (0.8); 0.488 (0.6); 0.482 (0.4); 0.464 (0.4); 0.428 (0.6); 0.410 (0.6); 0.403 (0.7); 0.392 (0.7); 0.386 (0.6); 0.374 (0.5); 0.368 (0.5); 0.350 (0.3); 0.020 (5.8)

    Example I-56

    [0430] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.420 (11.8); 7.879 (11.9); 7.686 (9.7); 7.580 (16.0); 7.300 (6.9); 4.763 (6.7); 4.714 (8.0); 4.282 (5.7); 4.233 (4.7); 4.156 (0.3); 4.132 (0.3); 3.487 (3.0); 3.440 (7.7); 3.387 (9.0); 3.340 (3.6); 2.844 (1.3); 2.074 (1.7); 2.043 (8.1); 1.892 (1.3); 1.311 (0.4); 1.288 (0.9); 1.264 (0.4); 0.886 (1.7); 0.879 (1.7); 0.868 (2.7); 0.862 (2.9); 0.844 (2.7); 0.829 (3.3); 0.788 (2.0); 0.767 (2.8); 0.751 (2.8); 0.732 (2.3); 0.726 (3.9); 0.719 (3.9); 0.693 (2.4); 0.675 (2.4); 0.656 (1.5); 0.602 (3.2); 0.587 (2.5); 0.568 (2.8); 0.563 (2.7); 0.552 (1.7); 0.545 (1.7); 0.538 (1.1); 0.027 (5.5)

    Example I-57

    [0431] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.646 (16.0); 8.525 (7.0); 8.509 (7.2); 8.484 (0.6); 7.892 (9.9); 7.698 (14.7); 7.658 (0.4); 7.646 (0.4); 7.534 (7.0); 7.518 (6.7); 7.479 (0.4); 7.462 (0.4); 7.300 (15.2); 6.882 (0.4); 4.762 (7.0); 4.713 (8.5); 4.291 (8.1); 4.242 (6.7); 4.187 (0.6); 4.163 (1.9); 4.139 (1.9); 4.126 (0.3); 4.116 (0.7); 3.511 (3.7); 3.465 (10.4); 3.420 (10.9); 3.373 (3.9); 2.996 (0.4); 2.650 (1.9); 2.619 (4.5); 2.077 (8.6); 2.043 (3.7); 1.814 (0.7); 1.315 (2.4); 1.291 (4.6); 1.267 (2.3); 0.852 (1.2); 0.838 (1.3); 0.832 (1.5); 0.821 (2.2); 0.807 (3.3); 0.797 (3.2); 0.786 (3.3); 0.768 (3.0); 0.758 (3.9); 0.754 (3.9); 0.737 (2.8); 0.726 (0.8); 0.719 (1.6); 0.706 (2.5); 0.677 (2.3); 0.663 (1.5); 0.651 (1.7); 0.638 (2.1); 0.628 (4.0); 0.613 (3.3); 0.602 (3.5); 0.592 (3.1); 0.582 (2.7); 0.575 (2.3); 0.562 (1.2); 0.557 (1.4); 0.549 (1.2); 0.537 (1.1); 0.042 (0.4); 0.031 (10.0); 0.020 (0.4)

    Example I-58

    [0432] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.884 (15.4); 7.703 (16.0); 7.668 (0.4); 7.654 (0.7); 7.380 (5.6); 7.374 (10.5); 7.368 (6.7); 7.336 (0.3); 7.298 (11.8); 7.286 (22.8); 7.280 (20.5); 7.145 (0.4); 7.139 (0.3); 4.666 (6.8); 4.617 (9.2); 4.362 (9.6); 4.313 (7.0); 3.537 (7.6); 3.491 (8.4); 3.100 (0.5); 2.765 (8.2); 2.719 (7.3); 2.343 (15.8); 2.044 (3.7); 1.728 (7.6); 0.807 (1.2); 0.785 (1.6); 0.772 (3.2); 0.749 (4.8); 0.738 (9.4); 0.725 (5.8); 0.705 (3.7); 0.690 (1.6); 0.670 (1.9); 0.602 (0.6); 0.567 (1.9); 0.554 (2.3); 0.537 (4.2); 0.518 (3.8); 0.497 (2.8); 0.434 (3.3); 0.416 (4.2); 0.395 (3.6); 0.380 (2.7); 0.366 (1.5); 0.044 (0.6); 0.033 (11.3)

    Example I-59

    [0433] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.025 (0.3); 8.021 (0.3); 7.957 (4.9); 7.955 (4.9); 7.848 (5.1); 7.845 (4.7); 7.800 (0.5); 7.223 (3.0); 7.207 (4.5); 7.190 (4.3); 7.165 (0.6); 7.089 (1.2); 7.073 (1.4); 7.061 (0.9); 5.570 (0.6); 5.396 (5.9); 5.329 (0.4); 4.567 (2.1); 4.518 (2.6); 4.480 (0.3); 4.137 (2.8); 4.088 (2.4); 4.061 (1.6); 4.037 (1.6); 4.014 (0.5); 3.341 (42.9); 3.135 (1.7); 3.089 (2.8); 2.980 (2.8); 2.934 (1.6); 2.533 (4.3); 2.527 (9.2); 2.521 (12.8); 2.515 (9.2); 2.509 (4.3); 2.307 (16.0); 2.009 (7.0); 1.218 (1.8); 1.195 (3.7); 1.171 (1.8); 0.674 (0.4); 0.657 (0.7); 0.651 (0.7); 0.634 (1.0); 0.621 (1.0); 0.616 (1.0); 0.608 (0.8); 0.579 (0.4); 0.546 (0.4); 0.523 (0.6); 0.513 (1.0); 0.497 (0.9); 0.482 (2.7); 0.454 (1.6); 0.444 (0.8); 0.423 (1.2); 0.406 (0.8); 0.397 (1.1); 0.381 (0.7); 0.372 (0.7); 0.031 (0.5); 0.020 (13.7); 0.009 (0.5)

    Example I-60

    [0434] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =7.988 (4.9); 7.877 (4.9); 7.344 (3.9); 7.310 (3.8); 5.786 (16.0); 5.699 (5.9); 4.603 (1.9); 4.554 (2.4); 4.222 (2.4); 4.173 (2.0); 4.067 (0.9); 4.043 (0.9); 3.354 (56.6); 3.333 (0.6); 3.194 (1.6); 3.149 (2.4); 3.002 (2.3); 2.956 (1.6); 2.534 (15.6); 2.528 (21.2); 2.522 (15.4); 2.489 (0.4); 2.459 (15.3); 2.420 (0.8); 2.309 (1.0); 2.015 (3.9); 1.355 (1.8); 1.261 (0.7); 1.224 (1.2); 1.200 (2.2); 1.177 (1.0); 1.081 (0.4); 0.640 (0.6); 0.620 (0.7); 0.606 (1.0); 0.598 (1.3); 0.583 (0.5); 0.562 (1.0); 0.550 (1.1); 0.529 (4.4); 0.508 (1.1); 0.497 (0.7); 0.475 (0.8); 0.441 (1.2); 0.435 (1.2); 0.420 (0.7); 0.400 (0.7); 0.387 (0.4); 0.037 (0.7); 0.026 (25.7); 0.015 (1.1)

    Example I-61

    [0435] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.886 (5.9); 7.713 (6.2); 7.378 (16.0); 7.351 (0.4); 7.320 (0.4); 7.300 (5.1); 7.236 (0.7); 7.226 (1.1); 4.678 (2.5); 4.630 (3.5); 4.611 (0.4); 4.401 (3.5); 4.383 (0.3); 4.352 (2.6); 3.530 (2.7); 3.485 (3.1); 3.312 (3.6); 3.020 (1.1); 2.919 (1.0); 2.843 (2.9); 2.798 (2.6); 2.050 (5.3); 1.841 (0.5); 0.757 (0.8); 0.732 (4.6); 0.724 (3.0); 0.712 (1.2); 0.692 (0.4); 0.569 (0.6); 0.540 (2.9); 0.531 (2.6); 0.521 (2.0); 0.509 (2.5); 0.484 (0.4); 0.478 (0.4); 0.033 (4.2)

    Example I-62

    [0436] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.425 (1.9); 8.408 (1.9); 7.889 (3.1); 7.730 (3.1); 7.728 (2.8); 7.390 (2.3); 7.300 (16.2); 7.286 (1.6); 7.281 (1.3); 4.689 (1.6); 4.641 (2.2); 4.401 (2.2); 4.352 (1.6); 3.580 (1.8); 3.535 (2.0); 2.795 (1.9); 2.750 (1.7); 2.111 (4.1); 1.625 (16.0); 0.760 (1.6); 0.749 (2.8); 0.740 (2.1); 0.704 (0.6); 0.560 (0.5); 0.554 (0.6); 0.549 (0.5); 0.544 (0.4); 0.528 (0.7); 0.518 (0.9); 0.513 (0.9); 0.504 (0.6); 0.417 (0.7); 0.409 (1.0); 0.406 (0.9); 0.397 (0.6); 0.382 (0.4); 0.373 (0.6); 0.370 (0.6); 0.361 (0.4); 0.048 (0.6); 0.037 (14.4); 0.026 (0.6)

    Example I-63

    [0437] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =8.032 (0.9); 7.972 (14.7); 7.844 (15.4); 7.813 (1.0); 7.698 (11.1); 7.679 (13.2); 7.634 (12.3); 7.614 (16.0); 7.500 (15.0); 7.480 (15.2); 7.464 (14.0); 7.444 (8.2); 7.372 (4.8); 7.354 (6.7); 7.336 (2.5); 5.758 (1.1); 5.492 (14.2); 5.416 (0.9); 4.592 (6.0); 4.555 (7.0); 4.181 (7.1); 4.145 (6.1); 4.071 (0.4); 4.036 (0.4); 3.325 (141.0); 3.209 (5.0); 3.174 (7.1); 3.149 (0.4); 3.114 (0.5); 3.045 (7.0); 3.025 (0.9); 3.011 (4.8); 2.991 (0.4); 2.676 (0.6); 2.511 (71.8); 2.507 (87.8); 2.334 (0.5); 0.681 (1.3); 0.666 (2.5); 0.652 (3.4); 0.640 (3.1); 0.626 (2.2); 0.547 (1.2); 0.529 (2.2); 0.522 (3.0); 0.504 (4.0); 0.491 (4.5); 0.476 (3.9); 0.459 (3.3); 0.451 (2.3); 0.432 (3.7); 0.421 (2.8); 0.415 (2.8); 0.407 (3.4); 0.394 (2.1); 0.389 (2.1); 0.376 (1.1)

    Example I-64

    [0438] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.860 (16.0); 7.659 (13.3); 7.657 (12.8); 7.368 (7.5); 7.340 (20.5); 7.308 (26.9); 7.300 (9.4); 7.286 (4.3); 7.280 (9.4); 5.325 (0.9); 4.646 (7.4); 4.597 (9.9); 4.332 (9.3); 4.284 (7.0); 3.531 (6.4); 3.485 (7.2); 2.800 (8.4); 2.754 (7.5); 2.648 (1.3); 2.567 (1.7); 2.544 (1.7); 2.067 (0.6); 2.050 (0.5); 2.032 (0.6); 0.740 (1.0); 0.719 (1.2); 0.705 (2.7); 0.677 (9.5); 0.649 (3.4); 0.634 (1.2); 0.631 (1.2); 0.614 (1.6); 0.571 (0.9); 0.536 (2.0); 0.529 (2.5); 0.523 (2.2); 0.510 (4.0); 0.493 (3.9); 0.488 (3.8); 0.472 (2.9); 0.408 (3.4); 0.392 (4.1); 0.372 (2.9); 0.364 (2.0); 0.356 (2.8); 0.346 (1.6); 0.311 (0.4); 0.026 (2.5)

    Example I-65

    [0439] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.879 (11.1); 7.671 (12.0); 7.440 (1.0); 7.430 (1.5); 7.424 (1.0); 7.418 (1.4); 7.411 (6.1); 7.400 (2.9); 7.393 (6.5); 7.387 (16.0); 7.380 (6.9); 7.367 (4.0); 7.346 (10.0); 7.338 (7.5); 7.320 (5.1); 7.314 (3.8); 7.300 (4.1); 4.675 (5.7); 4.626 (7.5); 4.326 (7.6); 4.278 (5.9); 3.556 (6.3); 3.510 (7.1); 2.845 (6.9); 2.799 (6.1); 2.198 (10.1); 1.866 (0.5); 0.770 (1.1); 0.752 (1.1); 0.748 (1.4); 0.735 (2.7); 0.717 (3.1); 0.712 (3.6); 0.697 (4.8); 0.694 (4.4); 0.679 (3.7); 0.675 (3.6); 0.657 (3.3); 0.644 (1.3); 0.640 (1.3); 0.622 (1.8); 0.583 (0.3); 0.544 (1.8); 0.529 (1.8); 0.524 (1.7); 0.511 (3.7); 0.494 (2.7); 0.488 (2.8); 0.471 (2.2); 0.391 (2.9); 0.373 (3.0); 0.369 (2.9); 0.352 (3.6); 0.337 (2.0); 0.334 (2.0); 0.319 (1.3); 0.033 (3.3)

    Example I-66

    [0440] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.757 (12.4); 7.494 (5.9); 7.484 (5.8); 7.479 (5.2); 7.469 (7.8); 7.457 (7.7); 7.301 (14.4); 7.276 (5.8); 7.249 (8.1); 7.223 (3.7); 7.004 (12.6); 5.320 (0.4); 4.496 (6.5); 4.447 (10.5); 4.298 (10.2); 4.249 (6.3); 3.491 (3.2); 3.443 (12.3); 3.412 (12.9); 3.365 (3.4); 2.280 (11.4); 2.083 (0.6); 1.690 (5.5); 1.321 (0.6); 1.293 (1.9); 1.274 (0.4); 0.941 (0.4); 0.919 (1.1); 0.908 (0.5); 0.894 (0.7); 0.886 (1.0); 0.860 (2.7); 0.838 (16.0); 0.824 (6.5); 0.817 (6.4); 0.810 (3.4); 0.807 (3.3); 0.794 (3.6); 0.784 (6.2); 0.757 (0.6); 0.735 (5.4); 0.725 (2.3); 0.712 (2.3); 0.704 (1.8); 0.693 (1.9); 0.666 (0.3); 0.038 (12.5)

    Example I-67

    [0441] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.306 (8.6); 8.290 (8.9); 7.752 (10.9); 7.718 (0.5); 7.695 (0.5); 7.690 (0.5); 7.678 (0.4); 7.655 (0.5); 7.649 (0.4); 7.594 (0.3); 7.575 (0.4); 7.570 (0.3); 7.515 (9.0); 7.499 (8.9); 7.300 (30.1); 7.021 (11.1); 7.019 (11.0); 4.511 (6.1); 4.462 (10.0); 4.321 (9.9); 4.272 (6.1); 3.509 (4.8); 3.463 (10.2); 3.387 (10.5); 3.341 (5.0); 2.381 (14.8); 2.083 (0.4); 1.641 (16.0); 1.291 (3.1); 0.928 (1.6); 0.920 (2.0); 0.913 (2.8); 0.901 (1.5); 0.887 (7.2); 0.874 (8.6); 0.854 (3.5); 0.839 (3.8); 0.821 (3.8); 0.810 (3.4); 0.786 (11.1); 0.778 (8.2); 0.759 (1.1); 0.748 (2.0); 0.736 (1.3); 0.702 (0.3); 0.048 (1.2); 0.037 (27.6); 0.026 (1.7)

    Example I-68

    [0442] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.769 (4.2); 7.300 (5.9); 7.224 (2.0); 7.198 (2.5); 7.125 (0.4); 7.114 (0.5); 7.048 (6.2); 7.023 (1.7); 6.996 (4.5); 6.994 (4.5); 5.337 (2.3); 4.413 (0.8); 4.364 (5.6); 4.350 (5.4); 4.301 (0.8); 3.416 (2.4); 3.368 (2.9); 2.916 (3.0); 2.869 (2.5); 2.340 (15.4); 2.282 (0.4); 2.215 (16.0); 1.722 (1.0); 1.323 (0.6); 1.293 (3.2); 1.248 (0.3); 0.953 (0.6); 0.938 (0.7); 0.929 (1.0); 0.920 (1.4); 0.909 (1.0); 0.896 (2.1); 0.884 (3.4); 0.870 (2.4); 0.855 (2.1); 0.848 (2.7); 0.824 (2.3); 0.817 (1.7); 0.807 (1.3); 0.800 (1.5); 0.783 (0.7); 0.724 (1.4); 0.710 (1.2); 0.695 (1.5); 0.688 (1.1); 0.676 (0.9); 0.669 (0.8); 0.658 (0.6); 0.109 (0.5); 0.039 (5.1)

    Example I-69

    [0443] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.722 (10.8); 7.719 (10.5); 7.526 (7.5); 7.498 (9.4); 7.432 (8.6); 7.425 (9.1); 7.300 (3.6); 7.287 (5.8); 7.280 (5.3); 7.259 (4.6); 7.252 (4.2); 6.951 (10.9); 6.948 (10.3); 4.465 (6.2); 4.416 (10.0); 4.275 (9.5); 4.226 (5.9); 3.389 (3.5); 3.341 (10.1); 3.296 (11.1); 3.248 (4.0); 2.807 (5.2); 2.063 (0.8); 2.034 (2.8); 0.865 (0.5); 0.856 (0.6); 0.833 (3.6); 0.815 (16.0); 0.810 (10.4); 0.800 (4.9); 0.793 (7.3); 0.784 (6.0); 0.778 (4.6); 0.771 (2.3); 0.756 (5.2); 0.750 (2.9); 0.737 (2.0); 0.735 (2.0); 0.729 (1.2); 0.718 (0.7); 0.710 (1.2); 0.702 (0.7); 0.029 (2.4)

    Example I-70

    [0444] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =7.732 (11.0); 7.729 (10.3); 7.655 (6.6); 7.627 (7.3); 7.509 (1.3); 7.497 (13.3); 7.489 (4.3); 7.475 (4.7); 7.467 (15.2); 7.456 (1.6); 7.136 (8.6); 7.128 (10.4); 7.118 (16.0); 7.111 (4.8); 7.096 (4.5); 7.088 (13.0); 7.077 (1.3); 7.045 (4.9); 7.037 (4.1); 7.017 (4.5); 7.008 (4.0); 6.965 (11.3); 6.961 (10.5); 5.779 (1.9); 5.253 (3.9); 4.467 (4.9); 4.418 (5.9); 4.012 (5.7); 3.964 (4.9); 3.351 (20.3); 3.302 (6.0); 3.153 (5.6); 3.106 (3.7); 2.537 (3.1); 2.531 (6.5); 2.525 (8.7); 2.519 (6.4); 2.513 (3.0); 1.027 (0.8); 1.011 (1.5); 0.992 (1.7); 0.985 (2.1); 0.970 (1.8); 0.961 (1.2); 0.947 (0.7); 0.793 (0.7); 0.772 (1.2); 0.756 (2.2); 0.725 (5.2); 0.702 (4.0); 0.688 (4.2); 0.667 (2.5); 0.646 (1.4); 0.629 (0.4); 0.032 (0.4); 0.021 (9.6); 0.010 (0.4)

    Example I-71

    [0445] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.761 (3.9); 7.365 (0.8); 7.359 (1.0); 7.352 (1.1); 7.343 (1.5); 7.333 (1.4); 7.321 (0.4); 7.300 (3.8); 7.239 (8.2); 7.230 (5.4); 7.190 (0.5); 6.991 (3.8); 6.989 (3.9); 4.423 (0.7); 4.374 (5.2); 4.360 (5.1); 4.311 (0.7); 3.453 (2.4); 3.406 (2.9); 2.968 (3.1); 2.921 (2.6); 2.370 (0.6); 2.261 (16.0); 2.196 (0.6); 1.781 (0.8); 1.293 (0.5); 0.959 (0.4); 0.943 (0.5); 0.934 (0.7); 0.926 (1.0); 0.920 (1.1); 0.901 (1.6); 0.891 (2.9); 0.885 (1.5); 0.880 (2.0); 0.858 (2.3); 0.850 (0.8); 0.832 (2.0); 0.826 (1.4); 0.815 (1.0); 0.808 (1.2); 0.791 (0.5); 0.711 (1.1); 0.696 (1.0); 0.681 (1.4); 0.675 (1.0); 0.662 (0.8); 0.656 (0.7); 0.645 (0.6); 0.038 (3.0)

    Example I-72

    [0446] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.630 (16.0); 8.509 (10.1); 8.492 (10.4); 7.760 (11.4); 7.757 (11.1); 7.545 (8.5); 7.528 (8.2); 7.300 (39.8); 7.021 (12.0); 7.018 (11.5); 5.338 (4.2); 4.498 (6.9); 4.449 (12.1); 4.331 (11.9); 4.282 (6.8); 3.453 (5.6); 3.407 (10.6); 3.313 (11.4); 3.266 (6.0); 2.341 (10.1); 1.666 (7.6); 1.291 (3.9); 1.258 (0.5); 0.939 (0.5); 0.913 (1.8); 0.900 (1.5); 0.891 (3.1); 0.866 (7.2); 0.858 (5.6); 0.852 (4.3); 0.846 (5.2); 0.835 (7.1); 0.824 (3.9); 0.815 (3.4); 0.805 (4.3); 0.798 (3.9); 0.792 (4.2); 0.784 (3.3); 0.780 (3.6); 0.770 (0.9); 0.742 (5.3); 0.736 (4.1); 0.716 (3.4); 0.709 (1.8); 0.704 (1.9); 0.693 (2.0); 0.665 (0.5); 0.106 (0.6); 0.047 (1.3); 0.036 (33.4); 0.025 (1.3)

    Example I-73

    [0447] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.750 (4.6); 7.301 (7.1); 7.276 (2.7); 7.251 (2.1); 7.171 (2.1); 7.134 (2.3); 7.100 (3.5); 6.992 (4.7); 4.426 (0.8); 4.377 (4.7); 4.359 (5.4); 4.310 (0.9); 3.504 (2.9); 3.459 (3.0); 2.626 (3.0); 2.580 (2.7); 2.382 (16.0); 1.945 (4.4); 1.708 (2.4); 1.294 (0.5); 1.247 (0.4); 0.921 (0.6); 0.835 (0.7); 0.814 (1.4); 0.797 (2.9); 0.794 (3.1); 0.775 (4.1); 0.767 (3.9); 0.746 (1.3); 0.736 (0.4); 0.729 (0.7); 0.709 (0.4); 0.459 (0.7); 0.445 (1.1); 0.436 (1.3); 0.430 (1.9); 0.406 (1.3); 0.390 (0.8); 0.038 (5.3)

    Example I-74

    [0448] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.645 (4.5); 7.403 (16.0); 7.300 (34.9); 6.949 (0.3); 6.929 (4.8); 6.926 (4.7); 5.339 (0.7); 4.519 (2.5); 4.469 (4.2); 4.338 (3.9); 4.288 (2.4); 3.668 (1.1); 3.484 (2.8); 3.438 (3.2); 2.738 (2.8); 2.693 (2.5); 1.617 (8.1); 1.292 (2.1); 0.918 (1.1); 0.911 (0.6); 0.892 (1.5); 0.882 (1.7); 0.873 (2.1); 0.861 (1.7); 0.856 (1.9); 0.838 (1.7); 0.820 (0.9); 0.784 (1.3); 0.765 (1.6); 0.748 (0.8); 0.742 (1.3); 0.730 (1.0); 0.706 (0.7); 0.673 (1.1); 0.654 (1.0); 0.647 (1.1); 0.639 (1.2); 0.628 (0.9); 0.619 (0.9); 0.613 (0.9); 0.593 (0.5); 0.107 (0.5); 0.049 (1.0); 0.038 (30.0); 0.027 (1.2)

    Example I-75

    [0449] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.360 (9.8); 8.343 (10.1); 7.648 (13.7); 7.646 (13.8); 7.457 (12.2); 7.362 (6.9); 7.357 (6.5); 7.345 (6.7); 7.340 (6.3); 7.300 (37.5); 6.906 (14.4); 6.903 (14.1); 5.322 (0.6); 4.539 (8.2); 4.490 (12.4); 4.314 (11.7); 4.265 (7.9); 3.870 (7.2); 3.506 (8.5); 3.460 (9.5); 2.743 (8.5); 2.698 (7.7); 1.666 (16.0); 1.291 (9.9); 0.927 (0.9); 0.917 (0.8); 0.908 (3.5); 0.896 (3.9); 0.881 (4.8); 0.870 (6.8); 0.863 (6.8); 0.844 (7.2); 0.839 (6.4); 0.820 (1.7); 0.740 (3.2); 0.720 (4.0); 0.710 (3.6); 0.693 (3.4); 0.688 (3.6); 0.681 (1.8); 0.661 (2.2); 0.627 (3.4); 0.607 (3.3); 0.603 (4.0); 0.591 (3.1); 0.581 (2.8); 0.573 (2.4); 0.567 (2.8); 0.547 (1.6); 0.106 (0.7); 0.048 (0.9); 0.037 (28.3); 0.026 (1.2)

    Example I-76

    [0450] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.746 (3.5); 7.301 (7.4); 7.189 (23.7); 6.991 (3.6); 4.419 (0.5); 4.370 (3.8); 4.356 (4.4); 4.307 (0.6); 3.503 (2.3); 3.457 (2.5); 2.622 (2.5); 2.576 (2.3); 2.385 (16.0); 2.360 (0.3); 1.875 (2.8); 1.673 (2.6); 1.293 (0.6); 0.921 (0.6); 0.832 (0.5); 0.809 (0.6); 0.803 (1.1); 0.795 (1.7); 0.784 (2.4); 0.781 (2.4); 0.771 (3.9); 0.769 (4.0); 0.756 (1.5); 0.749 (1.6); 0.741 (0.6); 0.732 (0.6); 0.457 (0.5); 0.445 (0.8); 0.433 (1.3); 0.430 (1.2); 0.406 (1.1); 0.394 (0.6); 0.039 (6.2)

    Example I-77

    [0451] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =7.759 (7.9); 7.411 (3.1); 7.403 (1.8); 7.381 (14.9); 7.366 (16.0); 7.345 (1.8); 7.337 (3.1); 6.988 (7.9); 6.985 (7.5); 5.334 (11.6); 4.388 (3.4); 4.339 (5.5); 4.203 (5.5); 4.154 (3.5); 3.346 (31.1); 3.202 (3.8); 3.156 (4.6); 2.775 (4.3); 2.729 (3.6); 2.530 (10.1); 2.524 (13.3); 2.518 (9.8); 2.097 (0.7); 2.012 (1.1); 1.197 (0.5); 0.624 (1.0); 0.605 (1.6); 0.597 (2.1); 0.590 (2.7); 0.583 (3.0); 0.571 (2.8); 0.563 (3.1); 0.551 (2.8); 0.535 (3.5); 0.519 (2.5); 0.497 (2.2); 0.484 (1.7); 0.473 (2.3); 0.459 (2.0); 0.444 (2.3); 0.432 (1.2); 0.415 (1.1); 0.397 (0.5); 0.023 (8.8)

    Example I-78

    [0452] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.681 (0.4); 7.672 (3.4); 7.667 (3.3); 7.657 (3.0); 7.653 (4.3); 7.646 (8.7); 7.645 (8.5); 7.554 (0.7); 7.551 (0.8); 7.540 (0.7); 7.536 (0.7); 7.390 (3.5); 7.386 (2.6); 7.376 (3.8); 7.372 (4.3); 7.362 (0.7); 7.354 (0.5); 7.343 (1.0); 7.340 (0.9); 7.328 (1.1); 7.325 (1.0); 7.301 (1.3); 7.278 (11.1); 7.251 (0.9); 7.247 (1.4); 7.236 (4.0); 7.232 (4.4); 7.230 (4.5); 7.224 (7.9); 7.218 (4.1); 7.215 (4.2); 7.210 (3.5); 7.200 (1.7); 7.196 (1.4); 7.191 (1.0); 7.177 (1.3); 7.174 (1.3); 7.162 (1.1); 7.159 (1.4); 7.155 (1.2); 7.144 (0.8); 7.140 (0.8); 7.130 (0.4); 7.126 (0.3); 6.538 (8.6); 6.537 (8.3); 6.208 (1.2); 6.206 (1.2); 5.301 (2.1); 4.609 (5.9); 4.579 (6.4); 4.463 (0.3); 4.189 (0.4); 4.178 (0.4); 4.140 (0.4); 4.126 (0.5); 4.112 (0.5); 4.097 (0.4); 4.075 (0.3); 4.061 (0.4); 4.046 (0.4); 4.035 (0.4); 4.027 (0.4); 4.017 (0.4); 4.007 (0.4); 3.996 (0.4); 3.987 (0.4); 3.975 (0.4); 3.964 (0.4); 3.958 (0.4); 3.946 (0.4); 3.935 (0.4); 3.925 (0.4); 3.915 (0.4); 3.906 (0.4); 3.877 (6.3); 3.847 (6.0); 3.825 (0.6); 3.807 (0.5); 3.793 (0.6); 3.780 (0.5); 3.764 (0.5); 3.754 (0.4); 3.725 (1.6); 3.720 (6.2); 3.704 (0.8); 3.698 (1.8); 3.691 (7.2); 3.679 (4.0); 3.666 (8.9); 3.653 (11.9); 3.639 (9.2); 3.626 (4.0); 3.613 (1.1); 3.598 (0.4); 3.587 (0.5); 3.580 (0.3); 3.567 (1.1); 3.553 (0.4); 3.539 (1.2); 3.525 (0.4); 3.204 (5.7); 3.176 (5.1); 3.117 (5.6); 3.102 (15.1); 3.087 (16.0); 3.072 (5.5); 3.056 (1.1); 3.045 (0.4); 2.347 (0.5); 2.041 (0.9); 1.600 (0.3); 1.557 (15.8); 1.542 (31.8); 1.527 (16.3); 1.486 (37.3); 1.474 (38.6); 1.411 (0.8); 1.396 (0.5); 1.358 (0.4); 1.344 (0.4); 1.257 (0.6); 1.243 (0.4); 1.236 (0.4); 1.228 (0.4); 1.225 (0.4); 1.217 (0.4); 1.215 (0.4); 1.207 (0.4); 1.204 (0.4); 1.194 (0.4); 1.088 (1.3); 1.074 (2.0); 1.067 (2.0); 1.061 (1.9); 1.052 (2.3); 1.040 (1.7); 0.972 (0.4); 0.961 (0.5); 0.958 (0.5); 0.948 (0.6); 0.941 (0.4); 0.937 (0.5); 0.927 (0.6); 0.887 (0.4); 0.876 (0.4); 0.873 (0.3); 0.866 (0.6); 0.855 (0.6); 0.852 (0.6); 0.842 (0.5); 0.809 (0.7); 0.804 (1.5); 0.799 (0.8); 0.789 (2.3); 0.783 (2.3); 0.777 (2.3); 0.768 (2.7); 0.756 (2.1); 0.645 (1.5); 0.633 (2.5); 0.624 (1.5); 0.619 (2.5); 0.612 (2.3); 0.600 (2.6); 0.589 (2.1); 0.586 (2.5); 0.579 (2.4); 0.574 (1.7); 0.567 (1.8); 0.544 (2.2); 0.553 (1.2); 0.006 (0.5); 0.000 (11.6); 0.006 (0.8)

    Example I-79

    [0453] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.730 (4.5); 7.656 (4.9); 7.654 (4.6); 7.469 (1.3); 7.462 (0.8); 7.453 (1.7); 7.450 (1.3); 7.440 (1.9); 7.429 (0.4); 7.425 (0.4); 7.358 (0.4); 7.347 (0.7); 7.344 (1.0); 7.335 (1.5); 7.326 (3.4); 7.316 (5.2); 7.307 (3.0); 7.298 (5.2); 7.293 (2.2); 7.284 (1.8); 7.270 (0.4); 4.494 (2.5); 4.445 (3.2); 4.108 (3.4); 4.060 (2.7); 3.320 (1.4); 3.272 (4.9); 3.237 (4.7); 3.189 (1.4); 1.920 (5.7); 1.721 (1.9); 1.399 (16.0); 1.340 (0.5); 0.447 (0.4); 0.432 (0.7); 0.417 (1.2); 0.405 (0.8); 0.400 (0.9); 0.386 (0.8); 0.263 (0.6); 0.247 (1.0); 0.234 (1.1); 0.221 (0.4); 0.214 (0.7); 0.203 (0.9); 0.181 (1.1); 0.169 (0.8); 0.163 (0.4); 0.153 (1.6); 0.139 (1.4); 0.135 (1.3); 0.122 (1.2); 0.095 (1.4); 0.084 (1.2); 0.076 (1.2); 0.065 (1.6); 0.054 (0.7); 0.047 (0.7); 0.033 (3.4)

    Example I-80

    [0454] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.714 (15.7); 7.684 (2.1); 7.668 (16.0); 7.648 (0.3); 7.501 (0.4); 7.498 (0.3); 7.478 (0.7); 7.467 (4.7); 7.455 (5.2); 7.449 (3.8); 7.446 (3.2); 7.436 (6.4); 7.423 (1.5); 7.368 (0.8); 7.357 (3.5); 7.345 (4.6); 7.338 (4.9); 7.326 (9.1); 7.309 (4.1); 7.299 (16.1); 7.297 (16.8); 7.285 (11.5); 7.277 (9.4); 7.265 (8.1); 7.253 (1.1); 7.236 (0.4); 7.188 (0.7); 7.175 (0.4); 7.170 (0.4); 7.157 (0.5); 4.588 (0.6); 4.454 (0.4); 4.445 (0.4); 4.369 (0.4); 4.321 (0.4); 4.301 (4.4); 4.253 (12.9); 4.208 (15.0); 4.189 (0.5); 4.160 (5.3); 4.142 (1.0); 4.119 (0.7); 4.087 (0.4); 3.287 (8.3); 3.241 (13.0); 3.136 (0.6); 3.089 (13.4); 3.043 (8.5); 2.078 (3.9); 1.901 (3.0); 1.879 (2.0); 1.842 (2.0); 1.781 (1.0); 1.766 (0.9); 1.742 (0.9); 1.341 (0.6); 1.316 (1.9); 1.300 (3.7); 1.293 (4.8); 1.269 (1.3); 1.056 (1.1); 1.038 (2.5); 1.029 (2.6); 1.021 (1.7); 1.011 (5.0); 1.001 (1.8); 0.993 (2.8); 0.983 (2.9); 0.965 (1.5); 0.937 (1.3); 0.916 (4.0); 0.892 (1.6); 0.395 (1.1); 0.380 (1.5); 0.377 (1.4); 0.364 (2.9); 0.349 (3.8); 0.335 (3.4); 0.321 (2.4); 0.318 (2.3); 0.304 (2.0); 0.287 (1.9); 0.274 (2.5); 0.270 (2.3); 0.257 (3.3); 0.246 (2.9); 0.243 (3.5); 0.229 (3.0); 0.216 (1.3); 0.212 (1.3); 0.198 (1.4); 0.165 (0.5); 0.105 (0.6); 0.045 (0.4); 0.034 (7.7); 0.026 (1.3); 0.010 (2.2); 0.007 (3.5); 0.024 (4.5); 0.039 (4.1); 0.056 (2.0); 0.065 (2.4); 0.078 (2.7); 0.082 (4.4); 0.095 (4.8); 0.114 (3.6); 0.128 (2.1); 0.146 (1.0)

    Example I-81

    [0455] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.772 (14.8); 7.655 (16.0); 7.653 (15.7); 7.457 (1.0); 7.448 (4.3); 7.440 (2.7); 7.433 (4.7); 7.430 (4.8); 7.418 (6.0); 7.408 (1.3); 7.404 (0.9); 7.331 (1.8); 7.320 (2.6); 7.316 (4.0); 7.308 (4.8); 7.298 (43.1); 7.285 (17.8); 7.276 (9.2); 7.270 (5.8); 7.268 (5.9); 7.263 (6.9); 7.253 (8.1); 7.240 (1.2); 7.230 (0.5); 4.241 (0.4); 4.177 (6.3); 4.128 (10.6); 3.995 (11.8); 3.947 (7.1); 3.132 (9.2); 3.085 (12.5); 2.844 (12.4); 2.797 (9.2); 2.751 (0.7); 2.723 (2.7); 2.711 (1.1); 2.692 (2.9); 2.675 (1.6); 2.665 (1.9); 2.653 (0.7); 2.637 (0.8); 2.183 (11.7); 2.044 (13.5); 1.924 (0.6); 1.891 (1.9); 1.873 (8.0); 1.868 (10.1); 1.860 (11.8); 1.852 (9.2); 1.847 (9.2); 1.840 (7.9); 1.834 (7.6); 1.814 (3.1); 1.804 (3.6); 1.774 (1.6); 1.754 (0.4); 1.743 (0.4); 1.721 (1.1); 1.709 (1.3); 1.696 (1.7); 1.688 (2.1); 1.677 (2.9); 1.661 (1.9); 1.653 (1.7); 1.630 (14.7); 1.610 (1.5); 1.603 (1.8); 1.590 (2.3); 1.582 (2.2); 1.559 (2.1); 1.535 (0.6); 1.531 (0.5); 0.106 (1.4); 0.047 (1.2); 0.036 (32.4); 0.025 (1.1)

    Example I-82

    [0456] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.764 (4.5); 7.624 (4.7); 7.622 (4.1); 7.461 (1.3); 7.454 (0.8); 7.447 (0.8); 7.442 (1.2); 7.439 (1.1); 7.430 (1.9); 7.362 (0.8); 7.352 (0.8); 7.349 (0.9); 7.345 (0.9); 7.338 (1.3); 7.330 (2.6); 7.317 (1.0); 7.301 (3.5); 7.298 (4.4); 7.294 (2.6); 7.283 (3.0); 7.274 (1.8); 7.270 (1.5); 7.265 (1.4); 7.250 (0.4); 4.380 (2.2); 4.332 (2.8); 3.961 (3.0); 3.913 (2.4); 3.148 (1.9); 3.101 (3.6); 3.008 (4.1); 2.961 (2.1); 2.381 (1.7); 2.374 (1.9); 1.802 (0.6); 1.797 (0.7); 1.782 (0.5); 1.759 (1.0); 1.736 (1.5); 1.713 (1.2); 1.690 (0.5); 1.153 (16.0); 1.130 (14.0); 0.031 (1.7)

    Example I-83

    [0457] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.029 (1.8); 7.855 (1.9); 7.852 (1.7); 7.581 (0.5); 7.572 (0.5); 7.556 (0.4); 7.549 (0.6); 7.471 (0.6); 7.465 (0.4); 7.449 (0.6); 7.440 (0.8); 7.312 (0.7); 7.305 (0.9); 7.292 (1.4); 7.281 (0.7); 7.271 (0.5); 4.761 (2.5); 4.317 (0.7); 4.269 (0.9); 4.047 (0.9); 4.040 (0.4); 4.000 (0.7); 3.349 (6.5); 3.221 (0.7); 3.175 (0.9); 2.828 (0.8); 2.781 (0.7); 2.536 (0.7); 2.531 (1.5); 2.525 (2.0); 2.519 (1.4); 2.513 (0.7); 2.012 (1.3); 1.521 (0.5); 1.471 (1.1); 1.407 (1.1); 1.357 (0.5); 1.221 (0.4); 1.197 (0.7); 1.173 (0.4); 0.973 (16.0); 0.022 (1.6)

    Example I-84

    [0458] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.806 (14.6); 7.695 (0.4); 7.658 (16.0); 7.656 (13.1); 7.501 (0.6); 7.462 (0.5); 7.452 (4.6); 7.444 (2.9); 7.438 (3.2); 7.433 (3.8); 7.430 (3.6); 7.421 (6.4); 7.409 (1.0); 7.400 (0.5); 7.389 (0.4); 7.377 (3.5); 7.368 (3.0); 7.365 (3.3); 7.360 (2.8); 7.353 (3.8); 7.346 (7.5); 7.335 (1.5); 7.313 (1.1); 7.305 (2.8); 7.300 (7.9); 7.289 (8.9); 7.284 (9.7); 7.281 (7.9); 7.271 (11.6); 7.261 (6.4); 7.258 (5.7); 7.253 (5.1); 7.237 (1.4); 7.229 (0.8); 5.094 (0.3); 4.885 (0.3); 4.458 (0.6); 4.410 (0.7); 4.359 (6.4); 4.311 (9.2); 4.109 (10.5); 4.061 (7.4); 3.291 (8.0); 3.245 (11.0); 3.010 (11.0); 2.963 (8.1); 2.555 (5.8); 2.076 (0.6); 2.039 (3.8); 1.787 (4.3); 1.759 (0.4); 1.673 (3.5); 1.653 (3.7); 1.625 (4.5); 1.605 (4.7); 1.341 (0.9); 1.314 (4.7); 1.289 (5.3); 1.266 (3.7); 1.241 (4.1); 0.875 (0.6); 0.867 (0.7); 0.849 (1.7); 0.839 (1.4); 0.830 (2.0); 0.824 (2.2); 0.815 (1.5); 0.804 (2.0); 0.786 (1.0); 0.779 (0.9); 0.762 (0.4); 0.652 (2.2); 0.637 (8.0); 0.626 (4.2); 0.615 (6.9); 0.599 (2.1); 0.183 (0.4); 0.168 (0.5); 0.147 (3.1); 0.133 (7.2); 0.128 (6.6); 0.117 (7.9); 0.102 (2.6); 0.086 (0.5); 0.080 (0.5); 0.032 (5.4)

    Example I-85

    [0459] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.761 (15.4); 7.636 (16.0); 7.442 (5.2); 7.436 (5.6); 7.416 (6.4); 7.410 (6.7); 7.298 (6.3); 7.273 (3.5); 7.266 (4.4); 7.247 (10.1); 7.241 (8.4); 7.218 (10.0); 7.206 (0.4); 7.193 (11.0); 7.167 (3.6); 4.163 (6.1); 4.135 (0.4); 4.114 (10.2); 3.984 (11.3); 3.936 (6.8); 3.179 (8.2); 3.133 (11.1); 2.890 (11.5); 2.843 (8.6); 2.749 (0.7); 2.722 (2.5); 2.713 (1.0); 2.694 (3.0); 2.675 (1.5); 2.668 (1.7); 2.663 (1.9); 2.642 (0.5); 2.635 (0.6); 2.486 (2.7); 2.473 (2.3); 2.461 (2.5); 2.447 (2.7); 2.073 (1.4); 1.927 (0.6); 1.897 (1.3); 1.885 (1.3); 1.860 (8.6); 1.854 (9.0); 1.845 (8.8); 1.836 (7.4); 1.828 (7.5); 1.823 (7.2); 1.816 (5.7); 1.799 (4.0); 1.771 (1.6); 1.755 (0.4); 1.717 (1.1); 1.705 (1.1); 1.687 (1.9); 1.680 (2.0); 1.671 (2.4); 1.659 (2.1); 1.649 (2.0); 1.632 (1.5); 1.627 (1.4); 1.609 (2.6); 1.601 (2.1); 1.582 (2.2); 1.576 (1.9); 1.547 (0.5); 1.334 (0.6); 1.311 (1.2); 1.294 (3.4); 1.287 (3.5); 1.263 (0.6); 0.931 (1.3); 0.909 (4.0); 0.886 (1.5); 0.100 (0.3); 0.028 (5.9)

    Example I-86

    [0460] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.836 (1.2); 7.705 (1.2); 7.363 (1.2); 7.357 (0.4); 7.342 (0.5); 7.335 (1.6); 7.302 (2.8); 7.152 (1.5); 7.130 (0.4); 7.125 (1.1); 4.394 (0.7); 4.346 (0.9); 4.006 (0.6); 3.958 (0.5); 2.980 (0.6); 2.935 (0.8); 2.561 (0.8); 2.515 (0.6); 1.741 (1.1); 1.626 (2.4); 1.613 (0.6); 1.563 (1.1); 1.460 (1.0); 1.410 (0.5); 1.084 (16.0); 0.039 (2.2)

    Example I-87

    [0461] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.806 (2.0); 7.741 (0.7); 7.725 (0.7); 7.657 (1.7); 7.493 (0.5); 7.478 (0.6); 7.386 (0.4); 7.383 (0.4); 7.371 (0.9); 7.369 (0.8); 7.356 (0.6); 7.353 (0.5); 7.315 (0.6); 7.312 (0.6); 7.300 (0.9); 7.297 (0.8); 7.285 (0.4); 7.282 (0.4); 7.259 (5.0); 4.554 (0.5); 4.525 (0.8); 4.415 (0.6); 4.386 (0.4); 3.537 (0.8); 1.558 (2.2); 1.422 (1.4); 1.370 (0.6); 1.336 (1.4); 1.332 (0.9); 1.284 (2.0); 1.256 (16.0); 1.177 (0.7); 1.162 (0.6); 1.157 (0.6); 1.142 (0.5); 1.107 (1.1); 1.087 (0.9); 1.074 (0.8); 1.048 (0.7); 1.041 (0.8); 1.036 (0.7); 1.029 (0.6); 1.021 (0.6); 1.006 (0.4); 0.902 (0.6); 0.894 (1.3); 0.889 (1.2); 0.881 (2.1); 0.869 (1.7); 0.856 (1.5); 0.848 (1.7); 0.842 (1.5); 0.834 (1.5); 0.818 (0.7); 0.754 (0.3); 0.731 (0.4); 0.716 (0.5); 0.683 (0.5); 0.673 (0.4); 0.669 (0.4); 0.659 (0.4); 0.000 (5.0)

    Example I-88

    [0462] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.887 (16.0); 7.686 (10.0); 7.663 (12.5); 7.626 (4.0); 7.599 (9.3); 7.572 (7.1); 7.523 (5.5); 7.497 (5.9); 7.472 (2.0); 7.301 (2.9); 4.683 (7.1); 4.635 (9.3); 4.372 (8.8); 4.323 (6.6); 3.634 (5.7); 3.588 (6.4); 3.071 (0.9); 3.023 (1.3); 2.996 (0.8); 2.957 (0.6); 2.910 (6.1); 2.864 (5.0); 2.034 (0.9); 0.695 (0.8); 0.648 (11.4); 0.603 (1.9); 0.570 (0.9); 0.530 (2.9); 0.525 (3.0); 0.519 (2.3); 0.512 (1.9); 0.496 (2.7); 0.489 (3.7); 0.484 (3.7); 0.477 (2.7); 0.442 (0.5); 0.374 (0.6); 0.330 (4.0); 0.326 (4.0); 0.305 (1.5); 0.294 (2.3); 0.290 (2.3); 0.028 (2.1)

    Example I-89

    [0463] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.707 (16.0); 7.646 (0.4); 7.614 (3.2); 7.587 (6.6); 7.558 (5.1); 7.503 (4.2); 7.478 (4.7); 7.452 (1.8); 7.300 (10.5); 6.952 (10.0); 5.320 (0.4); 4.500 (4.3); 4.451 (8.4); 4.359 (8.5); 4.310 (4.4); 3.609 (5.6); 3.563 (6.2); 3.529 (0.4); 3.505 (0.4); 2.950 (4.7); 2.768 (5.9); 2.722 (5.3); 1.727 (2.8); 1.292 (0.6); 1.269 (0.4); 1.246 (0.6); 1.223 (0.3); 0.920 (0.5); 0.851 (3.4); 0.848 (3.4); 0.820 (8.7); 0.790 (7.1); 0.710 (2.6); 0.690 (3.2); 0.675 (1.7); 0.662 (2.8); 0.651 (1.5); 0.631 (1.4); 0.442 (2.1); 0.421 (2.4); 0.414 (2.9); 0.391 (2.7); 0.382 (2.0); 0.361 (1.4); 0.037 (9.6)

    Example I-90

    [0464] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.891 (8.6); 7.869 (5.7); 7.687 (8.8); 7.576 (16.0); 7.572 (14.3); 7.300 (4.7); 4.765 (5.1); 4.716 (6.3); 4.311 (6.0); 4.263 (5.0); 3.578 (2.9); 3.530 (7.1); 3.471 (8.1); 3.423 (3.3); 2.543 (5.3); 1.759 (0.4); 1.291 (0.5); 0.914 (0.5); 0.808 (1.3); 0.802 (1.0); 0.780 (2.3); 0.774 (2.5); 0.766 (4.4); 0.743 (2.9); 0.739 (3.3); 0.735 (3.0); 0.724 (2.7); 0.704 (0.8); 0.699 (1.6); 0.688 (0.4); 0.659 (0.6); 0.596 (1.1); 0.580 (1.0); 0.569 (3.0); 0.557 (9.5); 0.542 (2.7); 0.529 (0.6); 0.514 (0.6); 0.105 (0.7); 0.033 (3.8)

    Example I-91

    [0465] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.908 (6.6); 7.734 (8.1); 7.527 (16.0); 7.494 (0.7); 7.301 (2.0); 6.953 (8.2); 4.483 (3.8); 4.434 (6.8); 4.322 (6.7); 4.273 (3.8); 4.160 (0.7); 4.136 (0.7); 3.488 (3.0); 3.440 (7.0); 3.379 (7.3); 3.331 (3.1); 3.015 (0.9); 2.087 (0.6); 2.073 (3.1); 1.364 (0.3); 1.312 (1.8); 1.288 (4.5); 1.265 (1.4); 0.973 (0.6); 0.963 (0.4); 0.951 (0.7); 0.912 (1.3); 0.889 (1.1); 0.876 (1.4); 0.854 (2.0); 0.841 (4.4); 0.824 (6.8); 0.814 (9.1); 0.796 (4.8); 0.781 (2.5); 0.776 (2.3); 0.756 (1.8); 0.720 (2.0); 0.707 (2.4); 0.690 (3.3); 0.666 (1.5); 0.653 (1.0); 0.031 (1.4)

    Example I-92

    [0466] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.908 (10.2); 8.773 (6.5); 8.756 (6.8); 7.851 (12.2); 7.784 (5.7); 7.767 (5.5); 7.640 (12.8); 7.638 (12.0); 7.300 (5.7); 4.703 (5.9); 4.654 (6.9); 4.136 (7.6); 4.087 (6.6); 3.493 (16.0); 2.978 (5.6); 2.974 (5.6); 2.037 (7.0); 2.009 (0.6); 1.283 (0.6); 1.022 (1.1); 1.003 (1.8); 0.986 (2.4); 0.978 (2.3); 0.967 (2.8); 0.961 (3.0); 0.933 (1.7); 0.902 (1.5); 0.879 (2.7); 0.867 (2.2); 0.860 (2.8); 0.839 (8.8); 0.819 (2.7); 0.813 (2.2); 0.801 (2.3); 0.777 (1.2); 0.651 (1.3); 0.624 (2.8); 0.617 (2.4); 0.607 (2.6); 0.599 (2.3); 0.582 (2.1); 0.564 (1.2); 0.099 (0.6); 0.026 (4.7)

    Example I-93

    [0467] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =7.920 (0.9); 7.881 (15.0); 7.844 (0.8); 7.812 (16.0); 7.810 (15.3); 7.776 (0.8); 7.733 (0.7); 7.304 (0.8); 7.301 (0.8); 7.281 (6.7); 7.268 (8.6); 7.254 (5.2); 7.245 (4.0); 7.221 (0.7); 5.505 (12.5); 4.716 (0.8); 4.557 (1.5); 4.480 (4.2); 4.477 (4.1); 4.443 (5.3); 4.441 (5.2); 4.210 (6.2); 4.173 (4.9); 3.305 (189.7); 3.195 (0.5); 3.182 (0.6); 3.161 (3.6); 3.126 (5.5); 3.011 (5.3); 2.976 (3.4); 2.664 (0.5); 2.659 (0.7); 2.655 (0.5); 2.494 (85.6); 2.490 (110.7); 2.486 (80.5); 2.321 (0.5); 2.317 (0.6); 2.313 (0.5); 0.818 (0.3); 0.808 (0.4); 0.785 (0.4); 0.780 (0.4); 0.759 (0.4); 0.613 (0.6); 0.594 (1.0); 0.583 (1.4); 0.564 (1.8); 0.549 (1.9); 0.532 (1.5); 0.517 (1.5); 0.513 (1.6); 0.497 (1.6); 0.479 (1.5); 0.475 (1.6); 0.460 (1.7); 0.445 (2.0); 0.430 (2.2); 0.411 (1.6); 0.396 (1.1); 0.382 (1.0); 0.353 (1.1); 0.333 (1.4); 0.325 (2.3); 0.319 (1.5); 0.310 (2.4); 0.299 (1.9); 0.292 (1.7); 0.284 (1.6); 0.266 (0.8); 0.045 (1.1); 0.030 (1.4); 0.025 (1.6); 0.018 (2.1); 0.011 (1.7); 0.000 (2.4); 0.008 (1.6); 0.015 (1.8); 0.023 (1.3); 0.027 (1.2); 0.042 (0.8)

    Example I-94

    [0468] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.757 (15.2); 7.693 (16.0); 7.690 (14.9); 7.663 (1.6); 7.646 (0.4); 7.460 (3.0); 7.454 (3.2); 7.434 (5.0); 7.429 (5.1); 7.410 (3.6); 7.404 (3.7); 7.363 (0.3); 7.300 (48.5); 7.263 (2.3); 7.258 (2.4); 7.237 (5.3); 7.217 (4.0); 7.211 (3.4); 7.174 (6.2); 7.171 (5.9); 7.148 (7.7); 7.145 (7.6); 7.122 (2.8); 7.119 (2.9); 5.426 (1.8); 5.418 (1.8); 4.617 (4.7); 4.611 (4.7); 4.569 (6.0); 4.562 (5.9); 4.392 (0.3); 4.233 (6.4); 4.230 (6.4); 4.185 (5.0); 4.181 (5.0); 3.333 (3.2); 3.286 (7.1); 3.216 (7.3); 3.168 (3.2); 2.997 (1.2); 2.919 (1.0); 2.211 (0.5); 2.129 (4.2); 2.116 (4.3); 1.683 (0.4); 1.672 (0.6); 1.660 (0.8); 1.627 (5.8); 1.610 (2.0); 1.604 (1.4); 1.589 (0.8); 1.582 (1.0); 1.569 (0.6); 0.857 (1.0); 0.838 (0.9); 0.833 (1.1); 0.813 (1.7); 0.798 (2.5); 0.793 (2.8); 0.779 (2.8); 0.770 (3.3); 0.756 (2.9); 0.753 (3.0); 0.747 (2.2); 0.738 (2.3); 0.731 (2.6); 0.726 (2.7); 0.713 (3.6); 0.703 (2.8); 0.690 (2.9); 0.687 (2.9); 0.671 (2.0); 0.650 (1.0); 0.646 (1.1); 0.628 (1.2); 0.423 (1.2); 0.401 (1.2); 0.389 (1.5); 0.384 (2.3); 0.366 (3.7); 0.349 (4.1); 0.332 (3.1); 0.322 (2.7); 0.315 (2.6); 0.309 (2.6); 0.304 (2.9); 0.287 (4.0); 0.274 (2.7); 0.269 (3.4); 0.252 (2.3); 0.236 (1.2); 0.231 (1.1); 0.212 (0.9); 0.107 (0.8); 0.048 (1.9); 0.037 (47.9); 0.027 (2.1)

    Example I-95

    [0469] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.756 (15.5); 7.729 (0.4); 7.688 (16.0); 7.661 (0.5); 7.300 (36.2); 7.249 (1.0); 7.242 (1.1); 7.222 (2.4); 7.216 (3.1); 7.209 (1.3); 7.198 (2.7); 7.191 (4.2); 7.182 (3.8); 7.167 (3.0); 7.162 (4.7); 7.159 (4.5); 7.156 (4.5); 7.138 (5.2); 7.126 (2.5); 7.112 (6.1); 7.106 (4.0); 7.085 (3.8); 7.072 (1.5); 7.066 (1.8); 7.045 (0.5); 4.620 (4.8); 4.614 (4.8); 4.572 (6.1); 4.565 (6.1); 4.230 (6.6); 4.227 (6.6); 4.194 (0.7); 4.182 (5.2); 4.178 (5.3); 4.170 (2.2); 4.146 (1.6); 4.123 (0.6); 3.347 (3.3); 3.299 (7.1); 3.222 (7.5); 3.174 (3.5); 2.161 (3.5); 2.118 (0.4); 2.083 (7.3); 1.640 (14.9); 1.321 (2.0); 1.297 (4.0); 1.273 (1.9); 0.865 (0.8); 0.842 (1.0); 0.823 (2.1); 0.805 (2.5); 0.801 (2.8); 0.786 (2.6); 0.774 (3.3); 0.756 (4.5); 0.738 (4.1); 0.719 (3.5); 0.707 (2.6); 0.693 (2.9); 0.672 (2.0); 0.649 (1.2); 0.630 (1.1); 0.437 (1.2); 0.417 (1.3); 0.415 (1.3); 0.403 (1.5); 0.397 (2.6); 0.380 (3.6); 0.363 (3.7); 0.343 (2.9); 0.327 (3.8); 0.312 (2.5); 0.307 (2.3); 0.291 (3.7); 0.277 (2.8); 0.272 (3.1); 0.255 (2.4); 0.239 (1.3); 0.234 (1.3); 0.215 (1.0); 0.107 (4.3); 0.048 (1.0); 0.037 (33.4); 0.026 (1.4)

    Example I-96

    [0470] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.730 (15.9); 7.677 (0.4); 7.654 (16.0); 7.640 (0.8); 7.504 (0.4); 7.500 (0.4); 7.312 (2.8); 7.300 (7.8); 7.284 (7.5); 7.258 (6.1); 7.190 (18.8); 7.159 (9.5); 7.153 (3.9); 4.640 (0.5); 4.635 (0.4); 4.626 (0.5); 4.621 (0.5); 4.584 (4.7); 4.578 (4.7); 4.535 (6.0); 4.529 (6.1); 4.218 (6.7); 4.215 (6.5); 4.170 (5.2); 4.166 (5.1); 3.270 (3.3); 3.222 (7.4); 3.150 (7.7); 3.103 (3.5); 2.682 (2.7); 2.039 (7.0); 1.926 (3.0); 1.917 (2.8); 0.829 (0.8); 0.809 (0.9); 0.804 (0.9); 0.788 (2.1); 0.769 (2.4); 0.764 (2.7); 0.748 (2.6); 0.738 (3.1); 0.721 (4.4); 0.700 (3.9); 0.682 (3.3); 0.671 (2.4); 0.656 (2.8); 0.653 (2.5); 0.634 (2.0); 0.616 (0.9); 0.612 (0.9); 0.593 (1.0); 0.436 (1.1); 0.416 (1.2); 0.413 (1.4); 0.402 (1.4); 0.395 (2.5); 0.378 (3.3); 0.360 (3.6); 0.344 (2.3); 0.341 (2.4); 0.325 (1.7); 0.301 (1.8); 0.285 (2.0); 0.280 (2.0); 0.265 (3.6); 0.250 (2.5); 0.246 (2.8); 0.230 (2.3); 0.223 (1.2); 0.213 (1.3); 0.208 (1.1); 0.188 (0.9); 0.029 (4.4)

    Example I-97

    [0471] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.744 (14.8); 7.669 (16.0); 7.352 (1.6); 7.344 (0.7); 7.330 (2.3); 7.322 (4.2); 7.300 (11.4); 7.273 (2.5); 6.969 (1.9); 6.960 (2.9); 6.942 (5.0); 6.935 (8.5); 6.914 (3.7); 6.908 (9.9); 6.900 (2.7); 6.879 (3.1); 6.871 (2.2); 5.424 (0.4); 5.417 (0.4); 4.589 (4.5); 4.583 (4.4); 4.540 (5.8); 4.534 (5.7); 4.221 (6.4); 4.217 (6.2); 4.172 (4.9); 4.169 (4.9); 3.272 (3.0); 3.224 (6.8); 3.150 (7.0); 3.102 (3.1); 2.482 (3.7); 2.477 (4.1); 2.465 (4.3); 2.460 (4.4); 2.041 (12.2); 1.822 (4.9); 1.803 (0.6); 1.290 (0.3); 0.830 (0.7); 0.810 (0.8); 0.806 (0.8); 0.788 (1.7); 0.770 (2.3); 0.765 (2.5); 0.752 (2.8); 0.744 (3.1); 0.731 (2.8); 0.728 (2.7); 0.721 (2.1); 0.710 (2.3); 0.703 (2.4); 0.699 (2.5); 0.685 (3.1); 0.678 (2.8); 0.665 (2.8); 0.661 (2.7); 0.644 (2.0); 0.624 (0.8); 0.621 (0.9); 0.602 (1.0); 0.423 (1.2); 0.404 (1.2); 0.401 (1.2); 0.389 (1.4); 0.382 (2.2); 0.366 (3.3); 0.348 (3.7); 0.332 (2.5); 0.329 (2.4); 0.315 (2.0); 0.308 (2.1); 0.294 (2.1); 0.289 (2.1); 0.273 (3.9); 0.259 (2.5); 0.255 (2.7); 0.239 (2.3); 0.233 (1.2); 0.222 (1.2); 0.216 (1.0); 0.198 (0.9); 0.103 (1.1); 0.031 (6.5)

    Example I-98

    [0472] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.748 (10.0); 7.666 (10.6); 7.587 (0.4); 7.561 (0.4); 7.488 (0.4); 7.477 (3.0); 7.464 (2.8); 7.458 (3.6); 7.446 (4.6); 7.433 (1.4); 7.427 (2.6); 7.415 (3.1); 7.410 (2.7); 7.406 (2.4); 7.396 (4.8); 7.384 (0.9); 7.345 (1.7); 7.332 (10.5); 7.321 (6.5); 7.313 (5.9); 7.300 (12.2); 7.288 (0.8); 5.028 (0.3); 4.632 (3.4); 4.625 (3.4); 4.583 (4.3); 4.577 (4.3); 4.232 (4.5); 4.228 (4.3); 4.183 (3.6); 4.179 (3.4); 3.382 (16.0); 3.379 (15.8); 2.566 (2.9); 2.040 (8.5); 0.879 (0.6); 0.858 (0.8); 0.854 (0.8); 0.838 (1.3); 0.818 (1.5); 0.813 (1.9); 0.795 (1.8); 0.787 (0.9); 0.771 (1.5); 0.768 (1.2); 0.763 (1.5); 0.752 (1.7); 0.746 (2.6); 0.741 (1.7); 0.728 (1.7); 0.722 (1.7); 0.705 (0.9); 0.697 (1.6); 0.679 (2.0); 0.675 (1.6); 0.656 (1.5); 0.639 (0.7); 0.634 (0.8); 0.615 (0.8); 0.473 (0.9); 0.452 (0.9); 0.449 (0.9); 0.439 (1.1); 0.434 (1.6); 0.414 (2.3); 0.411 (1.9); 0.400 (1.7); 0.392 (1.5); 0.380 (1.6); 0.377 (1.6); 0.358 (1.2); 0.335 (1.3); 0.317 (1.4); 0.311 (1.4); 0.300 (1.8); 0.293 (1.4); 0.282 (1.7); 0.277 (1.9); 0.263 (1.0); 0.258 (1.4); 0.244 (0.9); 0.239 (0.8); 0.219 (0.7); 0.033 (5.9)

    Example I-99

    [0473] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.709 (15.3); 7.626 (16.0); 7.350 (1.3); 7.347 (1.6); 7.339 (1.7); 7.335 (3.4); 7.332 (3.2); 7.319 (4.0); 7.315 (2.6); 7.305 (4.4); 7.291 (5.7); 7.288 (5.2); 7.276 (3.5); 7.273 (3.1); 7.265 (7.5); 7.179 (4.3); 7.177 (4.8); 7.164 (6.8); 7.162 (7.5); 7.149 (3.0); 7.147 (3.3); 7.136 (3.8); 7.117 (5.0); 7.099 (3.1); 7.098 (3.1); 4.554 (5.1); 4.551 (5.0); 4.525 (5.8); 4.521 (5.8); 4.160 (6.6); 4.131 (5.8); 3.499 (0.4); 3.485 (1.3); 3.471 (1.3); 3.457 (0.4); 3.252 (3.5); 3.223 (7.9); 3.181 (8.0); 3.153 (3.5); 2.416 (5.5); 2.413 (5.8); 2.403 (5.5); 2.400 (5.5); 1.722 (10.7); 1.311 (0.4); 1.297 (0.5); 1.284 (0.3); 1.220 (1.4); 1.206 (2.7); 1.192 (1.3); 0.896 (0.9); 0.882 (2.0); 0.867 (1.0); 0.766 (0.9); 0.753 (1.2); 0.751 (1.3); 0.742 (1.7); 0.739 (1.2); 0.727 (2.9); 0.714 (2.6); 0.701 (1.8); 0.699 (1.3); 0.686 (3.9); 0.674 (3.9); 0.660 (2.1); 0.647 (2.6); 0.635 (3.0); 0.633 (2.6); 0.620 (2.0); 0.610 (1.1); 0.608 (1.3); 0.596 (1.1); 0.387 (1.2); 0.372 (1.7); 0.366 (1.7); 0.363 (2.2); 0.359 (1.4); 0.351 (3.5); 0.343 (2.1); 0.337 (2.1); 0.330 (2.3); 0.329 (2.3); 0.316 (1.5); 0.269 (1.6); 0.257 (1.9); 0.254 (2.1); 0.247 (2.5); 0.242 (1.9); 0.234 (3.2); 0.226 (1.5); 0.222 (2.0); 0.213 (1.4); 0.211 (1.4); 0.198 (1.0); 0.006 (0.4); 0.000 (7.0)

    Example I-100

    [0474] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =7.859 (1.6); 7.845 (15.2); 7.797 (16.0); 7.796 (15.4); 7.743 (0.9); 7.741 (0.9); 7.357 (6.5); 7.343 (8.2); 7.336 (8.9); 7.321 (7.4); 7.277 (0.4); 7.263 (0.5); 7.256 (0.6); 7.242 (0.5); 7.138 (0.9); 7.119 (8.6); 7.097 (14.1); 7.075 (6.9); 5.738 (1.3); 5.393 (9.9); 5.388 (9.8); 4.475 (1.1); 4.465 (1.3); 4.453 (4.4); 4.416 (5.3); 4.095 (6.3); 4.058 (5.3); 3.306 (97.7); 3.111 (0.7); 3.088 (0.8); 3.057 (3.2); 3.022 (6.1); 2.955 (6.2); 2.920 (3.2); 2.656 (0.4); 2.496 (23.8); 2.492 (44.4); 2.487 (57.6); 2.483 (41.8); 2.314 (0.4); 0.765 (0.3); 0.759 (0.6); 0.547 (0.3); 0.532 (0.7); 0.519 (0.9); 0.515 (0.9); 0.503 (1.7); 0.489 (1.9); 0.485 (2.1); 0.473 (2.4); 0.468 (2.7); 0.452 (3.2); 0.438 (3.2); 0.433 (2.4); 0.423 (2.9); 0.418 (2.5); 0.408 (2.3); 0.404 (2.2); 0.390 (1.6); 0.374 (0.8); 0.360 (0.8); 0.312 (1.1); 0.298 (1.3); 0.295 (1.4); 0.282 (2.2); 0.271 (2.5); 0.256 (2.7); 0.245 (1.6); 0.231 (0.9); 0.025 (1.1); 0.014 (1.4); 0.010 (1.6); 0.000 (2.8); 0.013 (2.3); 0.016 (2.3); 0.025 (2.2); 0.038 (1.3); 0.043 (1.1); 0.057 (0.8)

    Example I-101

    [0475] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.897 (16.0); 7.686 (16.0); 7.405 (2.4); 7.385 (2.7); 7.377 (4.3); 7.357 (4.4); 7.350 (3.2); 7.330 (2.8); 7.300 (10.0); 7.081 (3.5); 7.075 (3.6); 7.053 (5.3); 7.048 (5.5); 7.025 (3.0); 7.019 (3.0); 4.744 (9.1); 4.695 (11.0); 4.258 (11.0); 4.209 (9.2); 4.163 (0.4); 4.139 (0.3); 3.402 (3.7); 3.397 (3.7); 3.354 (6.1); 3.349 (6.3); 3.215 (6.3); 3.212 (6.3); 3.167 (3.8); 3.164 (3.8); 2.395 (6.3); 2.379 (6.0); 2.078 (1.5); 1.790 (9.0); 1.338 (0.6); 1.315 (1.3); 1.298 (3.8); 1.292 (3.9); 1.268 (0.7); 0.935 (1.4); 0.914 (4.5); 0.890 (1.7); 0.778 (1.4); 0.766 (1.4); 0.759 (1.8); 0.756 (1.6); 0.735 (4.0); 0.724 (5.0); 0.717 (5.9); 0.710 (5.8); 0.702 (5.6); 0.699 (5.7); 0.692 (3.0); 0.675 (2.5); 0.663 (2.0); 0.652 (3.3); 0.642 (0.5); 0.621 (3.5); 0.609 (1.9); 0.603 (0.8); 0.590 (3.8); 0.573 (6.0); 0.563 (4.7); 0.548 (5.1); 0.541 (4.8); 0.530 (4.7); 0.518 (2.8); 0.505 (1.8); 0.498 (1.6); 0.486 (1.6); 0.032 (10.1); 0.021 (0.4)

    Example I-102

    [0476] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =8.172 (1.8); 8.038 (1.9); 7.549 (0.4); 7.530 (0.4); 7.477 (0.4); 7.456 (0.4); 5.982 (0.4); 4.872 (2.2); 4.636 (0.8); 4.599 (1.0); 4.337 (0.9); 4.301 (0.8); 3.547 (16.0); 3.306 (0.5); 3.271 (0.7); 3.101 (0.7); 3.065 (0.5); 2.736 (8.0); 2.732 (9.9); 2.728 (7.4); 1.443 (5.2); 0.437 (0.4); 0.213 (0.4); 0.017 (0.5); 0.000 (1.1); 0.017 (0.4)

    Example I-103

    [0477] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.900 (15.1); 7.692 (16.0); 7.300 (13.8); 7.224 (1.1); 7.216 (1.1); 7.206 (1.3); 7.196 (2.6); 7.187 (2.0); 7.170 (3.1); 7.163 (1.9); 7.152 (1.5); 7.144 (1.6); 7.090 (1.8); 7.084 (1.8); 7.067 (1.9); 7.060 (4.1); 7.053 (2.8); 7.036 (2.6); 7.030 (3.5); 7.023 (1.4); 7.006 (1.1); 7.000 (1.2); 4.751 (9.0); 4.702 (10.9); 4.249 (10.3); 4.200 (8.6); 3.402 (3.4); 3.398 (3.6); 3.354 (5.7); 3.349 (6.0); 3.208 (6.2); 3.164 (3.6); 3.160 (3.8); 2.245 (2.7); 2.080 (0.5); 2.045 (14.9); 1.729 (1.7); 0.789 (1.3); 0.777 (1.2); 0.769 (2.0); 0.751 (2.7); 0.745 (3.6); 0.734 (4.6); 0.727 (5.7); 0.721 (5.8); 0.713 (5.3); 0.710 (5.6); 0.701 (3.3); 0.682 (2.1); 0.675 (1.9); 0.663 (3.1); 0.648 (0.4); 0.631 (3.6); 0.619 (1.9); 0.613 (0.9); 0.598 (3.6); 0.583 (5.2); 0.580 (5.4); 0.572 (4.2); 0.553 (4.4); 0.546 (4.5); 0.536 (4.0); 0.525 (2.8); 0.511 (1.7); 0.503 (1.6); 0.491 (1.6); 0.046 (0.3); 0.035 (11.5); 0.024 (0.5)

    Example I-104

    [0478] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.792 (15.1); 7.664 (15.8); 7.661 (16.0); 7.644 (0.4); 7.298 (18.4); 7.029 (0.9); 7.009 (0.6); 6.996 (4.1); 6.984 (6.2); 6.980 (4.2); 6.968 (9.8); 6.955 (4.1); 6.951 (6.1); 6.938 (1.0); 6.926 (0.5); 6.918 (0.6); 4.112 (5.2); 4.063 (11.4); 3.988 (11.5); 3.940 (5.3); 2.946 (4.2); 2.941 (4.2); 2.899 (5.7); 2.893 (5.6); 2.688 (0.6); 2.651 (6.6); 2.645 (6.1); 2.632 (3.4); 2.616 (2.0); 2.603 (6.0); 2.598 (5.6); 2.580 (0.7); 2.573 (0.8); 2.133 (10.6); 2.044 (4.6); 1.948 (0.7); 1.920 (1.6); 1.884 (7.3); 1.875 (9.8); 1.868 (8.2); 1.853 (8.6); 1.841 (6.6); 1.833 (4.1); 1.826 (3.6); 1.812 (2.5); 1.798 (3.3); 1.772 (1.3); 1.748 (0.8); 1.740 (1.1); 1.728 (1.7); 1.716 (1.8); 1.704 (2.5); 1.695 (2.9); 1.675 (11.6); 1.660 (2.5); 1.652 (3.0); 1.641 (2.3); 1.624 (1.9); 1.618 (2.1); 1.607 (1.3); 1.587 (0.6); 0.044 (0.6); 0.034 (16.7); 0.023 (0.6)

    Example I-105

    [0479] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.805 (6.7); 7.732 (0.6); 7.728 (0.9); 7.723 (0.5); 7.712 (0.3); 7.705 (1.2); 7.700 (1.1); 7.692 (0.8); 7.688 (1.1); 7.683 (0.7); 7.672 (7.9); 7.670 (7.5); 7.660 (1.2); 7.593 (0.6); 7.587 (0.6); 7.573 (0.4); 7.568 (0.8); 7.563 (0.7); 7.529 (0.9); 7.519 (0.9); 7.515 (0.5); 7.509 (0.7); 7.504 (1.1); 7.499 (0.9); 7.494 (1.1); 7.481 (0.5); 7.476 (0.5); 7.471 (0.4); 7.298 (12.5); 7.034 (0.4); 7.003 (3.1); 6.991 (1.9); 6.986 (2.7); 6.977 (4.6); 6.961 (4.8); 6.932 (0.4); 4.306 (3.1); 4.257 (4.4); 4.024 (4.4); 3.975 (3.1); 3.074 (2.0); 3.068 (2.0); 3.026 (2.5); 3.021 (2.5); 2.670 (2.5); 2.665 (2.5); 2.622 (2.0); 2.617 (2.0); 2.080 (1.1); 2.028 (4.9); 2.026 (4.9); 2.024 (5.0); 1.744 (0.6); 1.721 (1.5); 1.699 (2.2); 1.675 (1.8); 1.653 (8.3); 1.318 (0.5); 1.294 (1.3); 1.288 (1.9); 1.271 (0.6); 1.139 (14.8); 1.131 (16.0); 1.116 (14.0); 1.108 (14.7); 0.046 (0.5); 0.035 (12.5); 0.024 (0.5)

    Example I-106

    [0480] .sup.1H-NMR (400.1 MHz, CDCl.sub.3): =7.788 (15.0); 7.677 (0.5); 7.653 (16.0); 7.261 (27.0); 6.996 (0.7); 6.991 (0.5); 6.972 (6.2); 6.959 (9.2); 6.946 (5.8); 6.937 (3.9); 6.914 (0.9); 5.298 (1.5); 4.257 (5.7); 4.221 (8.9); 4.147 (0.4); 4.129 (1.1); 4.112 (1.3); 4.099 (9.8); 4.063 (6.3); 3.074 (4.2); 3.071 (4.4); 3.039 (5.1); 3.036 (5.3); 2.726 (4.9); 2.722 (5.1); 2.690 (4.0); 2.686 (4.2); 2.223 (14.5); 2.042 (4.5); 2.004 (1.5); 1.801 (0.3); 1.576 (29.5); 1.546 (3.2); 1.530 (3.3); 1.509 (4.1); 1.494 (4.2); 1.303 (0.7); 1.275 (5.0); 1.258 (6.4); 1.239 (3.9); 1.221 (3.4); 0.776 (0.7); 0.763 (1.7); 0.756 (1.5); 0.745 (2.4); 0.728 (2.1); 0.714 (1.1); 0.710 (1.0); 0.697 (0.4); 0.633 (3.2); 0.621 (7.8); 0.611 (4.8); 0.603 (6.3); 0.591 (2.6); 0.108 (3.0); 0.096 (8.4); 0.085 (9.0); 0.008 (1.2); 0.000 (25.3)

    Example I-107

    [0481] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.893 (4.9); 7.674 (4.9); 7.300 (5.1); 7.269 (2.8); 7.242 (1.6); 7.030 (2.0); 7.004 (1.8); 6.992 (1.9); 6.953 (1.7); 4.730 (3.0); 4.682 (3.6); 4.201 (3.3); 4.152 (2.7); 3.311 (0.7); 3.263 (3.3); 3.240 (3.4); 3.191 (0.7); 2.401 (16.0); 2.357 (0.7); 2.349 (0.8); 2.334 (0.4); 2.317 (0.4); 0.767 (0.8); 0.755 (0.6); 0.749 (1.4); 0.724 (1.6); 0.722 (1.5); 0.716 (1.5); 0.701 (1.4); 0.691 (1.3); 0.684 (2.0); 0.671 (2.9); 0.663 (1.6); 0.653 (1.4); 0.644 (1.6); 0.641 (1.7); 0.631 (1.5); 0.623 (1.0); 0.613 (1.0); 0.559 (1.3); 0.554 (1.1); 0.550 (1.3); 0.528 (1.4); 0.518 (0.8); 0.507 (0.9); 0.036 (3.0)

    Example I-108

    [0482] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.755 (4.5); 7.467 (0.4); 7.311 (1.4); 7.301 (7.1); 7.285 (2.8); 7.259 (1.6); 7.032 (0.5); 7.001 (2.1); 6.984 (5.1); 6.957 (1.8); 6.918 (1.7); 5.338 (1.9); 5.321 (1.2); 4.454 (2.4); 4.405 (4.3); 4.291 (4.0); 4.242 (2.2); 4.171 (0.9); 4.147 (0.9); 3.295 (1.6); 3.247 (2.5); 3.075 (2.5); 3.028 (1.6); 2.393 (16.0); 2.231 (1.2); 2.207 (1.2); 2.083 (4.1); 1.827 (0.4); 1.815 (0.5); 1.711 (1.7); 1.561 (0.4); 1.549 (0.4); 1.321 (1.1); 1.297 (2.5); 1.273 (1.2); 0.827 (0.7); 0.804 (1.4); 0.792 (1.8); 0.782 (2.5); 0.768 (1.8); 0.763 (2.9); 0.748 (4.6); 0.733 (0.5); 0.725 (1.5); 0.710 (1.0); 0.688 (1.5); 0.669 (1.3); 0.658 (1.1); 0.654 (1.2); 0.645 (1.0); 0.627 (0.8); 0.610 (0.4); 0.038 (6.1)

    Example I-109

    [0483] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.875 (16.0); 7.682 (11.3); 7.300 (5.9); 7.274 (2.8); 7.268 (2.9); 7.249 (3.0); 7.242 (3.8); 7.238 (3.6); 7.230 (3.6); 7.212 (3.0); 7.205 (3.6); 7.199 (4.1); 7.193 (3.8); 7.165 (4.8); 7.138 (2.6); 7.100 (3.5); 7.091 (3.8); 7.066 (2.1); 4.651 (7.1); 4.603 (9.5); 4.353 (9.0); 4.305 (6.6); 3.530 (5.3); 3.484 (5.9); 2.781 (5.5); 2.735 (5.0); 2.655 (0.7); 2.633 (0.7); 2.565 (0.8); 2.532 (0.9); 2.481 (0.9); 2.075 (0.9); 2.042 (13.0); 1.862 (0.4); 1.290 (0.5); 0.765 (0.7); 0.743 (0.9); 0.731 (2.1); 0.706 (10.6); 0.701 (10.2); 0.684 (3.0); 0.677 (2.1); 0.648 (1.3); 0.588 (1.0); 0.575 (0.4); 0.548 (3.2); 0.542 (3.0); 0.528 (3.5); 0.512 (3.7); 0.508 (4.1); 0.492 (2.7); 0.463 (0.4); 0.414 (2.5); 0.399 (3.7); 0.387 (1.7); 0.380 (2.0); 0.365 (3.3); 0.030 (4.7)

    Example I-110

    [0484] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.832 (0.4); 7.793 (0.4); 7.674 (15.3); 7.624 (0.3); 7.612 (0.4); 7.321 (4.0); 7.300 (11.0); 7.257 (4.1); 7.185 (1.7); 7.157 (4.9); 7.126 (11.5); 7.106 (12.2); 7.017 (0.4); 6.994 (0.3); 6.908 (16.0); 5.321 (0.4); 4.494 (7.0); 4.445 (11.6); 4.306 (11.4); 4.257 (7.0); 3.526 (0.6); 3.484 (9.1); 3.438 (14.4); 2.677 (9.0); 2.630 (8.1); 1.823 (1.1); 1.813 (1.1); 1.351 (0.4); 1.327 (0.7); 1.294 (1.4); 1.268 (0.7); 1.244 (0.9); 1.221 (0.5); 0.940 (0.9); 0.918 (1.8); 0.901 (1.6); 0.883 (3.7); 0.858 (7.4); 0.848 (5.8); 0.824 (8.7); 0.803 (6.0); 0.783 (3.0); 0.736 (4.0); 0.716 (5.1); 0.690 (4.4); 0.683 (3.9); 0.657 (2.2); 0.551 (3.3); 0.530 (5.1); 0.515 (4.1); 0.507 (3.7); 0.496 (4.2); 0.472 (2.1); 0.035 (7.2)

    Example I-111

    [0485] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.955 (12.1); 7.821 (11.6); 7.560 (3.0); 7.544 (6.3); 7.527 (3.5); 7.397 (3.6); 7.393 (3.8); 7.377 (3.8); 7.373 (3.9); 7.272 (4.0); 7.268 (3.9); 7.255 (3.7); 7.251 (3.5); 5.749 (12.8); 5.463 (12.7); 4.567 (5.0); 4.538 (5.7); 4.120 (6.1); 4.091 (5.6); 3.301 (29.2); 3.106 (16.0); 2.504 (4.5); 2.501 (5.9); 2.498 (4.3); 0.778 (1.2); 0.766 (2.0); 0.764 (2.0); 0.757 (2.0); 0.752 (2.1); 0.745 (2.4); 0.743 (2.3); 0.731 (1.8); 0.633 (1.2); 0.618 (2.0); 0.612 (2.2); 0.606 (1.8); 0.597 (2.6); 0.585 (1.9); 0.512 (1.7); 0.501 (2.5); 0.498 (2.1); 0.491 (1.7); 0.486 (2.4); 0.480 (2.0); 0.477 (1.6); 0.465 (1.4); 0.439 (1.9); 0.427 (2.0); 0.424 (2.2); 0.417 (2.3); 0.413 (2.0); 0.406 (1.9); 0.403 (2.0); 0.392 (1.2); 0.000 (3.1)

    Example I-112

    [0486] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.955 (12.0); 7.821 (11.5); 7.561 (3.0); 7.544 (6.2); 7.527 (3.4); 7.396 (3.6); 7.392 (3.9); 7.377 (3.8); 7.373 (3.9); 7.272 (4.0); 7.268 (3.9); 7.255 (3.7); 7.251 (3.5); 5.749 (15.4); 5.464 (12.8); 4.567 (5.0); 4.538 (5.7); 4.120 (6.0); 4.091 (5.5); 3.303 (25.0); 3.106 (16.0); 2.505 (3.7); 2.501 (4.9); 2.498 (3.6); 0.779 (1.2); 0.766 (2.0); 0.765 (2.0); 0.757 (2.0); 0.753 (2.1); 0.745 (2.4); 0.743 (2.3); 0.731 (1.8); 0.633 (1.2); 0.618 (2.0); 0.612 (2.2); 0.606 (1.8); 0.597 (2.6); 0.585 (1.9); 0.512 (1.7); 0.501 (2.5); 0.498 (2.2); 0.491 (1.7); 0.487 (2.4); 0.480 (2.0); 0.465 (1.4); 0.439 (1.8); 0.428 (2.0); 0.425 (2.2); 0.418 (2.3); 0.414 (1.9); 0.407 (1.8); 0.403 (2.0); 0.392 (1.1); 0.000 (2.2)

    Example I-113

    [0487] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.742 (12.1); 7.529 (3.4); 7.512 (7.0); 7.496 (3.9); 7.363 (4.0); 7.359 (4.3); 7.344 (4.2); 7.339 (4.4); 7.244 (4.4); 7.240 (4.3); 7.228 (4.1); 7.224 (3.9); 6.952 (11.3); 5.275 (16.0); 4.375 (5.8); 4.346 (7.4); 4.139 (7.4); 4.109 (6.1); 3.307 (7.5); 3.152 (4.5); 3.124 (5.5); 2.902 (5.4); 2.874 (4.4); 2.506 (2.4); 2.503 (3.3); 2.499 (2.4); 0.728 (0.4); 0.711 (2.1); 0.706 (1.9); 0.703 (1.6); 0.697 (2.6); 0.686 (3.1); 0.680 (2.6); 0.671 (0.7); 0.649 (1.9); 0.640 (2.7); 0.637 (2.7); 0.627 (3.5); 0.616 (3.5); 0.597 (6.0); 0.583 (11.8); 0.570 (3.0); 0.563 (1.2); 0.557 (0.7); 0.550 (0.8); 0.000 (3.1)

    Example I-114

    [0488] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =7.742 (12.7); 7.529 (3.5); 7.512 (7.2); 7.496 (4.0); 7.363 (4.1); 7.359 (4.3); 7.344 (4.2); 7.340 (4.4); 7.244 (4.6); 7.241 (4.4); 7.228 (4.2); 7.224 (4.0); 6.952 (11.8); 5.275 (16.0); 4.375 (6.0); 4.346 (7.6); 4.139 (7.6); 4.109 (6.2); 3.307 (8.6); 3.153 (4.7); 3.124 (5.8); 2.902 (5.7); 2.874 (4.6); 2.506 (2.7); 2.502 (3.6); 2.499 (2.7); 0.728 (0.4); 0.711 (2.2); 0.706 (2.0); 0.703 (1.7); 0.697 (2.7); 0.686 (3.3); 0.680 (2.7); 0.671 (0.7); 0.649 (2.0); 0.640 (2.8); 0.637 (2.8); 0.627 (3.7); 0.616 (3.6); 0.597 (6.2); 0.583 (12.2); 0.571 (3.2); 0.563 (1.2); 0.557 (0.7); 0.550 (0.8); 0.000 (2.8)

    Example I-115

    [0489] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.656 (4.8); 7.627 (5.2); 7.626 (4.9); 7.263 (4.6); 7.187 (1.1); 7.172 (2.4); 7.160 (0.6); 7.155 (2.1); 7.143 (1.4); 7.139 (2.6); 7.135 (2.8); 7.133 (2.6); 7.124 (1.9); 7.119 (3.8); 7.115 (1.2); 5.297 (16.0); 4.196 (1.7); 4.167 (4.4); 4.133 (4.3); 4.104 (1.8); 3.053 (1.6); 3.051 (1.6); 3.025 (2.0); 3.023 (2.1); 2.826 (1.9); 2.824 (2.0); 2.799 (1.5); 2.796 (1.6); 1.602 (0.9); 0.933 (0.3); 0.922 (0.7); 0.916 (0.8); 0.911 (0.6); 0.905 (1.5); 0.900 (0.6); 0.895 (0.9); 0.889 (0.9); 0.878 (0.5); 0.340 (0.3); 0.330 (0.5); 0.329 (0.5); 0.321 (0.7); 0.312 (1.2); 0.304 (0.8); 0.301 (0.9); 0.294 (0.8); 0.293 (0.8); 0.283 (0.6); 0.259 (0.6); 0.250 (0.8); 0.248 (0.8); 0.242 (0.8); 0.239 (0.9); 0.232 (1.2); 0.223 (0.9); 0.220 (0.7); 0.215 (0.6); 0.213 (0.6); 0.204 (0.5); 0.000 (4.8); 0.028 (0.4); 0.038 (0.9); 0.048 (1.2); 0.058 (1.5); 0.068 (1.4); 0.078 (0.6); 0.110 (0.6); 0.121 (1.2); 0.130 (1.3); 0.141 (1.1); 0.150 (0.8); 0.161 (0.4)

    Example I-116

    [0490] .sup.1H-NMR (499.9 MHz, d.sub.6-DMSO): =8.144 (5.6); 7.865 (1.9); 7.737 (15.8); 7.575 (16.0); 7.354 (4.6); 7.338 (10.3); 7.332 (7.8); 7.328 (8.1); 7.321 (7.9); 7.313 (8.0); 7.309 (8.0); 7.191 (6.3); 7.187 (6.3); 7.174 (5.4); 7.170 (5.4); 5.153 (3.4); 4.658 (7.0); 4.630 (8.2); 4.327 (8.0); 4.299 (7.1); 3.311 (0.5); 2.910 (5.3); 2.883 (6.6); 2.687 (5.9); 2.660 (4.7); 2.509 (3.2); 2.505 (6.5); 2.502 (9.0); 2.498 (6.8); 2.495 (3.6); 0.810 (0.9); 0.799 (2.0); 0.793 (2.4); 0.789 (2.1); 0.782 (4.1); 0.772 (2.7); 0.766 (2.4); 0.755 (1.2); 0.000 (4.5); 0.011 (0.9); 0.017 (1.1); 0.021 (1.2); 0.028 (3.0); 0.034 (2.7); 0.039 (2.9); 0.045 (3.8); 0.056 (2.1); 0.062 (1.8); 0.071 (1.6); 0.078 (1.9); 0.082 (2.2); 0.089 (3.4); 0.095 (2.5); 0.099 (3.2); 0.106 (3.5); 0.116 (1.7); 0.123 (2.7); 0.130 (2.0); 0.135 (2.6); 0.141 (3.7); 0.152 (3.9); 0.159 (2.8); 0.170 (1.3); 0.303 (1.2); 0.314 (2.5); 0.321 (3.7); 0.332 (3.6); 0.339 (2.3); 0.349 (1.2)

    Example I-117

    [0491] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.784 (7.2); 7.628 (7.6); 7.298 (2.3); 7.216 (1.1); 7.189 (3.0); 7.164 (2.8); 7.140 (8.0); 7.111 (4.6); 4.091 (2.4); 4.043 (4.9); 3.963 (4.9); 3.914 (2.4); 2.912 (2.1); 2.908 (2.0); 2.866 (2.9); 2.862 (2.9); 2.646 (3.0); 2.642 (3.0); 2.626 (0.9); 2.600 (3.2); 2.595 (3.1); 2.562 (2.0); 2.556 (2.1); 2.539 (1.2); 2.517 (0.7); 2.067 (0.9); 2.032 (16.0); 1.925 (0.6); 1.916 (0.6); 1.892 (1.3); 1.887 (1.5); 1.867 (3.1); 1.853 (4.4); 1.846 (3.7); 1.835 (2.7); 1.827 (2.5); 1.799 (0.8); 1.790 (1.1); 1.762 (0.6); 1.712 (0.6); 1.696 (0.6); 1.671 (1.5); 1.661 (0.9); 1.652 (0.9); 1.646 (0.8); 1.618 (0.6); 1.608 (0.8); 1.599 (1.0); 1.592 (1.0); 1.587 (1.0); 1.576 (0.8); 1.567 (1.1); 1.539 (0.3); 1.282 (0.5); 0.023 (1.8)

    Example I-118

    [0492] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.811 (6.8); 7.676 (7.6); 7.673 (7.2); 7.298 (14.6); 7.222 (1.0); 7.195 (3.1); 7.171 (11.6); 7.166 (5.3); 7.148 (3.1); 7.142 (3.9); 4.306 (3.2); 4.257 (4.4); 4.012 (4.4); 3.964 (3.2); 3.044 (2.2); 3.040 (2.3); 2.997 (2.8); 2.993 (3.0); 2.668 (2.8); 2.664 (3.1); 2.621 (2.2); 2.617 (2.5); 1.960 (4.5); 1.952 (4.5); 1.735 (0.6); 1.712 (1.6); 1.689 (2.2); 1.666 (1.8); 1.643 (0.9); 1.627 (11.5); 1.130 (14.8); 1.120 (16.0); 1.107 (14.0); 1.097 (14.5); 0.047 (0.5); 0.036 (15.0); 0.025 (0.6)

    Example I-119

    [0493] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.022 (1.8); 7.854 (1.9); 7.852 (1.7); 7.493 (0.4); 7.466 (1.0); 7.438 (0.6); 7.423 (0.6); 7.416 (0.7); 7.390 (0.6); 7.383 (0.7); 7.273 (0.7); 7.266 (0.6); 7.246 (0.5); 7.238 (0.5); 4.756 (2.5); 4.277 (0.6); 4.229 (0.9); 4.076 (0.9); 4.029 (0.6); 3.348 (6.6); 3.036 (0.5); 2.990 (0.6); 2.638 (0.6); 2.592 (0.5); 2.537 (0.7); 2.531 (1.5); 2.525 (2.1); 2.519 (1.5); 2.513 (0.7); 2.098 (0.5); 1.451 (0.4); 1.402 (1.0); 1.358 (1.0); 1.308 (0.4); 0.965 (16.0); 0.022 (1.6)

    Example I-120

    [0494] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.828 (11.7); 7.713 (0.4); 7.688 (12.3); 7.320 (0.3); 7.300 (15.9); 7.248 (2.1); 7.222 (5.2); 7.197 (4.4); 7.172 (12.6); 7.143 (8.3); 5.338 (2.5); 4.300 (4.3); 4.251 (7.5); 4.193 (0.5); 4.169 (1.3); 4.146 (1.5); 4.129 (8.0); 4.081 (4.5); 3.101 (4.3); 3.055 (5.5); 2.760 (5.4); 2.714 (4.1); 2.283 (11.7); 2.082 (5.6); 2.045 (1.8); 1.638 (16.0); 1.594 (2.4); 1.573 (2.6); 1.546 (3.3); 1.525 (3.5); 1.320 (2.2); 1.296 (5.2); 1.272 (3.4); 1.267 (3.9); 1.243 (2.5); 1.219 (2.7); 0.918 (0.6); 0.835 (0.7); 0.817 (1.5); 0.794 (2.1); 0.773 (1.9); 0.753 (1.0); 0.729 (0.4); 0.664 (2.5); 0.648 (7.1); 0.632 (3.9); 0.624 (6.0); 0.607 (1.9); 0.141 (2.4); 0.126 (8.0); 0.110 (8.9); 0.095 (2.0); 0.036 (15.2)

    Example I-121

    [0495] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.678 (2.9); 7.638 (2.9); 7.300 (2.1); 7.264 (0.7); 7.235 (1.5); 7.210 (1.4); 7.184 (1.5); 7.177 (2.3); 7.169 (1.5); 7.162 (1.2); 7.154 (0.9); 7.150 (0.8); 7.136 (1.3); 7.129 (0.9); 5.334 (2.3); 4.046 (1.0); 4.044 (1.0); 3.998 (2.0); 3.904 (2.1); 3.856 (1.1); 3.471 (16.0); 2.907 (0.9); 2.902 (0.9); 2.860 (1.1); 2.854 (1.1); 2.418 (1.3); 2.415 (1.3); 2.371 (1.1); 2.368 (1.1); 1.712 (0.5); 0.652 (0.4); 0.638 (0.4); 0.628 (0.6); 0.621 (0.7); 0.615 (0.5); 0.605 (1.5); 0.599 (0.9); 0.587 (1.0); 0.581 (1.5); 0.560 (1.9); 0.547 (0.4); 0.537 (0.9); 0.476 (1.4); 0.465 (0.7); 0.453 (2.0); 0.431 (1.1); 0.409 (0.4); 0.034 (2.2)

    Example I-122

    [0496] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.746 (8.2); 7.443 (2.2); 7.415 (4.8); 7.389 (2.9); 7.300 (30.4); 7.164 (4.8); 7.142 (6.7); 7.113 (4.3); 6.996 (9.0); 4.459 (4.2); 4.409 (5.7); 4.129 (5.6); 4.078 (4.2); 3.915 (0.5); 3.893 (2.2); 3.868 (3.6); 3.845 (2.8); 3.821 (1.0); 3.797 (0.9); 3.774 (2.8); 3.750 (3.7); 3.726 (2.2); 3.700 (0.7); 3.178 (3.3); 3.128 (5.8); 3.008 (5.9); 2.958 (3.4); 2.179 (0.5); 2.061 (1.1); 1.989 (1.0); 1.295 (6.4); 1.259 (8.9); 1.236 (16.0); 1.214 (8.3); 1.142 (0.6); 1.061 (0.4); 1.007 (2.3); 0.995 (2.3); 0.972 (3.0); 0.920 (1.2); 0.868 (4.1); 0.827 (13.3); 0.798 (2.0); 0.704 (0.3); 0.038 (24.4)

    Example I-123

    [0497] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.679 (10.8); 7.452 (3.5); 7.440 (1.0); 7.423 (7.2); 7.396 (4.4); 7.300 (36.5); 7.155 (3.9); 7.147 (7.3); 7.142 (6.9); 7.135 (5.3); 7.124 (5.0); 7.122 (4.8); 7.108 (6.2); 7.101 (4.0); 6.972 (11.6); 6.969 (11.5); 6.949 (0.4); 5.957 (1.0); 5.941 (1.9); 5.923 (1.5); 5.906 (2.2); 5.900 (1.5); 5.890 (1.4); 5.884 (2.4); 5.866 (1.8); 5.849 (2.5); 5.833 (1.3); 5.287 (1.7); 5.281 (4.6); 5.276 (5.1); 5.271 (2.2); 5.240 (2.2); 5.235 (5.4); 5.230 (6.2); 5.224 (5.4); 5.219 (4.5); 5.213 (2.1); 5.205 (2.0); 5.200 (4.8); 5.195 (4.4); 4.490 (7.4); 4.439 (10.1); 4.417 (1.3); 4.412 (2.0); 4.406 (1.4); 4.402 (1.4); 4.396 (2.0); 4.391 (1.2); 4.377 (1.9); 4.371 (3.3); 4.366 (2.3); 4.362 (2.3); 4.356 (3.2); 4.351 (1.9); 4.271 (3.2); 4.259 (2.1); 4.254 (3.3); 4.231 (2.0); 4.219 (1.2); 4.214 (1.8); 4.167 (9.7); 4.117 (7.3); 3.987 (0.5); 3.224 (3.7); 3.174 (6.5); 3.050 (7.5); 2.999 (4.4); 1.741 (1.6); 1.667 (0.6); 1.292 (1.4); 1.034 (0.4); 1.009 (1.6); 1.001 (2.6); 0.984 (4.1); 0.967 (3.8); 0.960 (3.8); 0.946 (1.1); 0.924 (2.6); 0.911 (4.0); 0.906 (3.8); 0.891 (4.4); 0.871 (4.9); 0.855 (1.1); 0.848 (3.5); 0.840 (8.6); 0.823 (16.0); 0.802 (4.8); 0.789 (1.1); 0.771 (1.0); 0.048 (0.6); 0.037 (26.6); 0.026 (1.3)

    Example I-124

    [0498] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.750 (4.7); 7.646 (5.0); 7.298 (1.7); 7.265 (0.6); 7.244 (0.8); 7.235 (1.4); 7.214 (1.5); 7.208 (1.0); 7.186 (0.8); 6.929 (0.6); 6.919 (1.2); 6.913 (1.1); 6.903 (1.3); 6.893 (1.9); 6.884 (1.2); 6.877 (1.9); 6.869 (1.6); 6.849 (1.1); 6.841 (0.7); 4.417 (2.3); 4.368 (3.3); 4.143 (3.2); 4.095 (2.3); 3.159 (1.4); 3.156 (1.3); 3.112 (2.0); 3.108 (2.0); 2.924 (2.0); 2.877 (1.4); 2.874 (1.4); 2.031 (5.8); 1.899 (2.4); 1.346 (16.0); 0.259 (0.6); 0.234 (4.2); 0.213 (0.8); 0.189 (0.5); 0.098 (0.7); 0.090 (0.5); 0.072 (1.2); 0.056 (3.4); 0.046 (3.5); 0.039 (1.7); 0.027 (1.0); 0.023 (1.7); 0.015 (0.4); 0.009 (0.4); 0.001 (0.4)

    Example I-125

    [0499] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.887 (15.3); 7.886 (15.3); 7.672 (16.0); 7.670 (15.5); 7.646 (0.4); 7.465 (2.2); 7.444 (2.7); 7.437 (5.0); 7.416 (5.1); 7.409 (3.1); 7.387 (2.7); 7.300 (6.4); 6.984 (2.0); 6.982 (2.0); 6.976 (2.6); 6.973 (2.7); 6.955 (3.7); 6.946 (5.7); 6.938 (4.1); 6.930 (3.5); 6.919 (3.3); 6.910 (4.1); 6.904 (4.4); 6.896 (2.9); 6.876 (3.2); 6.867 (2.5); 4.727 (9.5); 4.678 (11.4); 4.235 (11.2); 4.186 (9.3); 4.160 (0.3); 3.350 (3.7); 3.348 (3.7); 3.302 (7.2); 3.299 (7.3); 3.205 (7.6); 3.157 (3.9); 2.446 (7.7); 2.424 (7.6); 2.073 (1.3); 2.038 (5.2); 1.855 (2.6); 1.312 (0.4); 1.288 (0.8); 1.264 (0.3); 0.759 (1.6); 0.750 (1.6); 0.743 (2.1); 0.724 (4.2); 0.708 (5.4); 0.700 (6.7); 0.695 (6.7); 0.687 (7.0); 0.684 (6.6); 0.675 (3.9); 0.656 (2.2); 0.649 (2.6); 0.641 (4.5); 0.624 (4.5); 0.615 (2.5); 0.605 (0.6); 0.593 (4.5); 0.580 (5.7); 0.576 (5.5); 0.569 (4.8); 0.564 (2.0); 0.549 (5.1); 0.542 (5.1); 0.535 (2.0); 0.528 (3.3); 0.521 (3.4); 0.507 (2.0); 0.499 (1.8); 0.491 (1.7); 0.101 (0.4); 0.029 (4.2)

    Example I-126

    [0500] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =10.098 (0.4); 7.969 (0.4); 7.946 (0.5); 7.863 (0.3); 7.838 (0.4); 7.765 (12.2); 7.675 (0.4); 7.638 (0.4); 7.587 (1.9); 7.559 (4.4); 7.535 (4.5); 7.506 (2.0); 7.421 (0.4); 7.228 (2.5); 7.221 (2.6); 7.196 (4.5); 7.188 (4.5); 7.163 (2.5); 7.155 (2.5); 7.090 (2.7); 7.061 (4.7); 7.034 (2.4); 6.978 (12.1); 6.934 (0.5); 5.781 (1.5); 5.430 (0.3); 5.328 (0.5); 5.283 (14.6); 4.654 (0.4); 4.641 (0.4); 4.411 (5.2); 4.362 (7.5); 4.151 (7.6); 4.102 (5.2); 4.039 (0.3); 4.028 (0.4); 3.429 (0.4); 3.345 (58.4); 3.168 (4.4); 3.120 (6.3); 3.078 (0.4); 2.935 (6.3); 2.887 (4.3); 2.751 (0.6); 2.662 (0.4); 2.525 (49.8); 2.385 (0.4); 2.297 (0.4); 0.720 (2.5); 0.704 (3.1); 0.688 (5.3); 0.639 (6.9); 0.613 (8.0); 0.598 (16.0); 0.503 (0.5); 0.377 (0.3); 0.219 (0.3); 0.023 (37.8); 0.078 (0.6); 0.221 (0.4); 0.271 (0.4); 3.211 (0.3)

    Example I-127

    [0501] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.796 (15.7); 7.646 (16.0); 7.298 (8.7); 7.249 (1.8); 7.240 (0.6); 7.228 (2.4); 7.220 (4.7); 7.198 (4.3); 7.192 (3.2); 7.170 (2.7); 6.922 (1.9); 6.913 (2.9); 6.896 (4.5); 6.888 (7.3); 6.862 (8.6); 6.834 (3.1); 6.826 (2.1); 4.101 (5.2); 4.053 (10.9); 3.970 (11.1); 3.922 (5.4); 2.916 (4.4); 2.912 (4.3); 2.869 (6.1); 2.865 (6.1); 2.665 (0.7); 2.646 (6.5); 2.641 (7.5); 2.624 (1.4); 2.610 (2.9); 2.599 (5.9); 2.580 (2.0); 2.567 (0.7); 2.550 (0.8); 2.292 (2.7); 2.244 (1.2); 2.039 (6.4); 1.923 (0.7); 1.914 (0.8); 1.893 (2.5); 1.873 (8.6); 1.861 (9.7); 1.852 (10.0); 1.845 (8.6); 1.831 (4.5); 1.828 (4.5); 1.825 (4.5); 1.813 (2.8); 1.796 (3.0); 1.782 (1.6); 1.768 (2.3); 1.750 (0.9); 1.733 (0.6); 1.721 (1.3); 1.714 (1.0); 1.708 (1.1); 1.695 (1.7); 1.681 (3.1); 1.668 (2.0); 1.655 (1.9); 1.644 (0.9); 1.622 (1.6); 1.610 (2.0); 1.600 (2.5); 1.586 (1.8); 1.578 (2.1); 1.564 (1.0); 1.549 (0.6); 0.030 (7.2)

    Example I-128

    [0502] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.792 (7.2); 7.636 (7.8); 7.634 (7.5); 7.298 (3.4); 7.271 (0.9); 7.250 (1.0); 7.241 (2.1); 7.231 (0.4); 7.220 (2.1); 7.214 (1.5); 7.192 (1.2); 6.929 (0.9); 6.919 (1.6); 6.910 (1.5); 6.902 (2.7); 6.893 (2.7); 6.880 (1.6); 6.874 (3.1); 6.869 (2.4); 6.867 (2.4); 6.846 (1.6); 6.838 (1.0); 4.301 (3.5); 4.253 (4.6); 3.996 (4.4); 3.947 (3.3); 3.027 (2.1); 3.024 (2.1); 2.980 (2.7); 2.976 (2.7); 2.671 (2.9); 2.624 (2.2); 2.252 (4.2); 2.245 (4.7); 1.786 (3.4); 1.735 (0.6); 1.712 (1.6); 1.689 (2.3); 1.666 (1.9); 1.644 (0.8); 1.328 (0.3); 1.306 (0.4); 1.128 (15.0); 1.118 (16.0); 1.105 (14.3); 1.095 (14.4); 0.030 (2.9)

    Example I-129

    [0503] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.024 (1.7); 8.022 (1.7); 7.853 (1.8); 7.850 (1.7); 7.491 (0.5); 7.468 (0.5); 7.462 (0.3); 7.211 (0.4); 7.205 (0.4); 7.056 (0.5); 7.049 (0.4); 4.734 (2.6); 4.266 (0.6); 4.219 (0.9); 4.069 (0.9); 4.022 (0.6); 3.349 (4.6); 3.022 (0.5); 2.976 (0.6); 2.640 (0.6); 2.594 (0.5); 2.537 (0.5); 2.531 (1.0); 2.525 (1.4); 2.519 (1.0); 2.513 (0.5); 1.453 (0.4); 1.403 (1.0); 1.349 (1.0); 1.300 (0.4); 0.961 (16.0); 0.873 (0.4); 0.784 (0.5); 0.022 (0.9)

    Example I-130

    [0504] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.821 (14.5); 7.688 (0.5); 7.666 (15.4); 7.664 (14.7); 7.520 (0.4); 7.475 (0.4); 7.300 (8.5); 7.291 (1.9); 7.279 (0.6); 7.270 (2.1); 7.261 (4.4); 7.248 (0.9); 7.239 (4.1); 7.233 (3.0); 7.212 (2.5); 7.017 (0.3); 6.932 (1.7); 6.922 (2.9); 6.910 (2.9); 6.903 (5.2); 6.898 (5.7); 6.873 (6.2); 6.847 (3.2); 6.839 (2.1); 4.444 (0.4); 4.392 (0.4); 4.295 (5.4); 4.247 (9.3); 4.121 (10.1); 4.072 (6.0); 3.098 (4.2); 3.094 (4.3); 3.051 (5.5); 3.047 (5.6); 2.763 (5.3); 2.760 (5.4); 2.716 (4.1); 2.713 (4.2); 2.473 (12.1); 2.041 (1.5); 1.814 (0.5); 1.764 (16.0); 1.586 (3.1); 1.565 (3.3); 1.538 (4.3); 1.527 (1.8); 1.517 (4.5); 1.312 (0.7); 1.292 (4.3); 1.268 (4.7); 1.244 (3.2); 1.220 (3.5); 0.853 (0.6); 0.845 (0.7); 0.827 (1.6); 0.817 (1.4); 0.803 (2.2); 0.793 (1.5); 0.780 (1.9); 0.763 (1.0); 0.756 (0.9); 0.740 (0.4); 0.658 (3.1); 0.641 (7.5); 0.627 (4.4); 0.617 (6.3); 0.600 (2.7); 0.139 (3.0); 0.124 (8.0); 0.108 (8.7); 0.093 (2.2); 0.042 (0.4); 0.031 (5.9)

    Example I-131

    [0505] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.763 (4.7); 7.666 (5.0); 7.380 (0.4); 7.373 (0.4); 7.362 (0.5); 7.355 (1.1); 7.348 (0.9); 7.329 (1.2); 7.322 (0.7); 7.311 (0.6); 7.300 (4.2); 7.270 (0.6); 7.264 (0.7); 7.246 (1.5); 7.239 (1.5); 7.221 (1.4); 7.214 (1.1); 7.199 (1.8); 7.197 (1.8); 7.172 (2.3); 7.150 (0.8); 7.147 (0.8); 7.140 (1.1); 7.134 (1.5); 7.105 (1.0); 4.446 (2.4); 4.397 (3.3); 4.150 (3.1); 4.102 (2.2); 3.194 (1.3); 3.147 (2.2); 3.007 (2.3); 2.959 (1.4); 1.819 (1.6); 1.803 (1.6); 1.696 (1.5); 1.690 (2.2); 1.679 (0.9); 1.370 (16.0); 1.343 (0.7); 0.310 (0.3); 0.297 (0.4); 0.281 (0.7); 0.262 (2.4); 0.251 (2.7); 0.234 (0.9); 0.215 (0.4); 0.205 (0.5); 0.104 (0.7); 0.093 (0.4); 0.080 (0.9); 0.062 (2.7); 0.059 (2.8); 0.050 (3.0); 0.043 (2.1); 0.036 (4.1); 0.027 (0.7); 0.018 (0.4); 0.012 (0.4); 0.004 (0.4)

    Example I-132

    [0506] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.857 (10.6); 7.638 (10.7); 7.404 (1.8); 7.401 (2.0); 7.389 (3.8); 7.385 (4.2); 7.373 (2.2); 7.370 (2.4); 7.356 (1.2); 7.352 (1.1); 7.345 (1.3); 7.341 (2.7); 7.337 (2.1); 7.329 (2.3); 7.325 (2.9); 7.321 (1.6); 7.313 (1.6); 7.310 (1.4); 7.262 (9.3); 7.196 (3.1); 7.195 (3.2); 7.181 (5.2); 7.180 (5.2); 7.166 (2.4); 7.165 (2.4); 7.136 (2.8); 7.116 (3.4); 7.098 (2.5); 5.297 (16.0); 4.697 (6.9); 4.668 (7.8); 4.183 (7.4); 4.154 (6.8); 3.317 (2.8); 3.289 (6.0); 3.242 (6.3); 3.213 (3.0); 2.340 (6.6); 2.324 (6.7); 1.637 (4.8); 1.255 (0.3); 1.241 (0.3); 0.719 (1.3); 0.710 (1.5); 0.706 (1.5); 0.699 (2.7); 0.690 (2.9); 0.685 (3.2); 0.676 (3.7); 0.664 (3.2); 0.655 (3.4); 0.653 (3.7); 0.643 (3.8); 0.636 (1.0); 0.632 (2.0); 0.623 (2.9); 0.616 (0.5); 0.604 (2.9); 0.595 (2.1); 0.591 (1.2); 0.583 (3.9); 0.573 (3.6); 0.571 (3.3); 0.562 (2.8); 0.550 (0.4); 0.532 (3.3); 0.523 (3.0); 0.518 (2.9); 0.510 (3.2); 0.502 (2.0); 0.498 (1.9); 0.489 (1.6); 0.006 (0.3); 0.000 (9.1); 0.007 (0.5)

    Example I-133

    [0507] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.858 (11.5); 7.639 (11.6); 7.403 (1.9); 7.400 (2.2); 7.388 (4.0); 7.385 (4.5); 7.373 (2.3); 7.370 (2.5); 7.356 (1.1); 7.353 (1.1); 7.345 (1.3); 7.341 (2.8); 7.338 (2.2); 7.329 (2.3); 7.325 (3.1); 7.321 (1.7); 7.314 (1.6); 7.310 (1.4); 7.262 (10.6); 7.197 (3.2); 7.195 (3.5); 7.182 (5.4); 7.180 (5.7); 7.167 (2.4); 7.165 (2.5); 7.136 (2.9); 7.116 (3.6); 7.099 (2.5); 5.297 (16.0); 4.697 (7.4); 4.668 (8.3); 4.183 (7.9); 4.154 (7.1); 3.317 (3.0); 3.289 (6.5); 3.242 (6.8); 3.213 (3.1); 2.330 (7.0); 2.314 (7.1); 1.626 (5.0); 1.255 (0.4); 1.241 (0.4); 0.719 (1.3); 0.710 (1.5); 0.706 (1.6); 0.699 (2.9); 0.690 (3.1); 0.685 (3.4); 0.676 (3.9); 0.665 (3.4); 0.656 (3.6); 0.653 (3.9); 0.644 (3.8); 0.636 (1.0); 0.632 (1.9); 0.623 (2.8); 0.615 (0.4); 0.604 (2.8); 0.594 (2.1); 0.591 (1.2); 0.583 (4.0); 0.573 (3.6); 0.571 (3.5); 0.562 (2.8); 0.532 (3.3); 0.524 (3.1); 0.518 (3.0); 0.511 (3.4); 0.502 (1.9); 0.498 (1.9); 0.489 (1.5); 0.006 (0.4); 0.000 (10.3); 0.007 (0.7)

    Example I-134

    [0508] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.441 (0.5); 8.030 (16.0); 7.698 (1.0); 7.695 (1.0); 7.663 (1.1); 7.466 (0.8); 7.460 (0.9); 7.441 (1.9); 7.435 (2.1); 7.416 (1.3); 7.410 (1.4); 7.390 (0.4); 7.385 (0.4); 7.330 (0.4); 7.323 (0.7); 7.315 (0.6); 7.313 (0.6); 7.300 (4.4); 7.289 (1.5); 7.279 (2.2); 7.272 (2.0); 7.263 (1.2); 7.261 (1.2); 7.253 (1.9); 7.247 (1.0); 7.232 (1.9); 7.226 (1.7); 7.215 (0.5); 7.207 (1.5); 7.201 (1.2); 7.190 (0.6); 7.187 (0.7); 7.164 (2.1); 7.160 (2.1); 7.147 (1.9); 7.143 (2.9); 7.139 (3.1); 7.135 (3.1); 7.122 (2.2); 7.118 (3.6); 7.111 (2.2); 7.105 (1.9); 7.101 (1.5); 7.097 (1.4); 7.093 (1.6); 7.088 (1.5); 7.083 (2.1); 7.078 (2.3); 7.072 (2.3); 7.067 (2.0); 7.055 (1.2); 7.052 (1.1); 7.044 (1.3); 7.041 (1.2); 7.033 (0.5); 4.758 (0.5); 4.749 (1.2); 4.700 (4.7); 4.670 (4.6); 4.621 (1.2); 4.570 (0.6); 4.521 (0.4); 4.192 (0.5); 4.169 (1.7); 4.150 (9.5); 4.141 (5.4); 4.121 (0.7); 4.006 (0.5); 3.950 (0.5); 3.396 (0.4); 3.351 (0.5); 3.327 (1.5); 3.280 (2.6); 3.166 (2.2); 3.162 (2.2); 3.120 (1.3); 3.115 (1.3); 3.064 (0.4); 3.059 (0.4); 2.080 (7.3); 2.033 (8.3); 1.806 (1.6); 1.318 (1.9); 1.294 (3.8); 1.271 (1.9); 0.807 (0.4); 0.771 (0.4); 0.753 (1.0); 0.746 (0.8); 0.735 (0.6); 0.728 (2.2); 0.719 (1.7); 0.716 (1.8); 0.709 (1.5); 0.705 (1.7); 0.696 (2.3); 0.693 (2.6); 0.679 (1.2); 0.674 (2.0); 0.658 (1.4); 0.646 (1.9); 0.631 (1.7); 0.620 (0.9); 0.616 (0.8); 0.605 (1.3); 0.598 (1.1); 0.589 (0.4); 0.572 (0.6); 0.519 (1.2); 0.503 (1.1); 0.498 (1.3); 0.484 (1.2); 0.480 (1.2); 0.469 (0.8); 0.461 (0.9); 0.444 (0.6); 0.037 (2.9)

    Example I-135

    [0509] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =8.328 (1.3); 8.065 (0.9); 7.919 (5.3); 7.746 (5.4); 7.425 (1.2); 7.423 (1.2); 7.410 (2.3); 7.407 (2.3); 7.395 (1.4); 7.392 (1.4); 7.292 (0.5); 7.289 (0.6); 7.282 (0.6); 7.278 (1.4); 7.274 (1.3); 7.260 (10.2); 7.251 (0.9); 7.247 (0.9); 7.144 (1.5); 7.143 (1.6); 7.129 (2.8); 7.128 (2.9); 7.115 (1.6); 7.113 (1.6); 7.081 (1.5); 7.074 (0.6); 7.072 (0.6); 7.063 (2.2); 7.046 (1.3); 7.044 (1.3); 7.016 (0.3); 5.296 (1.3); 4.886 (0.8); 4.716 (2.5); 4.687 (4.0); 4.601 (3.9); 4.571 (2.4); 4.462 (0.5); 4.427 (0.6); 4.267 (1.0); 4.256 (2.1); 4.249 (0.7); 4.241 (6.5); 4.234 (1.6); 4.227 (6.8); 4.219 (1.0); 4.213 (2.5); 4.205 (0.8); 4.201 (0.8); 4.197 (0.7); 4.161 (0.4); 4.119 (4.7); 4.093 (0.6); 3.965 (0.8); 3.936 (0.4); 3.931 (0.7); 3.906 (0.4); 3.487 (0.5); 3.457 (0.4); 3.359 (2.8); 3.330 (3.0); 3.292 (0.9); 3.284 (0.6); 3.263 (0.4); 3.238 (0.3); 3.209 (0.6); 3.135 (0.5); 3.114 (2.2); 3.111 (2.3); 3.086 (1.8); 3.083 (1.8); 2.954 (0.3); 1.612 (10.0); 1.319 (7.9); 1.305 (16.0); 1.291 (8.3); 1.278 (2.9); 1.264 (1.6); 1.256 (0.4); 1.228 (0.4); 0.909 (0.5); 0.894 (0.4); 0.891 (0.4); 0.879 (0.3); 0.775 (0.8); 0.764 (1.3); 0.760 (1.2); 0.753 (1.6); 0.749 (1.9); 0.742 (1.5); 0.739 (1.5); 0.734 (1.2); 0.732 (1.2); 0.728 (1.6); 0.719 (1.1); 0.715 (0.7); 0.708 (0.7); 0.705 (1.2); 0.698 (1.5); 0.694 (0.7); 0.687 (1.3); 0.684 (1.8); 0.673 (1.3); 0.647 (1.5); 0.636 (1.6); 0.633 (1.3); 0.626 (0.9); 0.622 (1.4); 0.616 (1.1); 0.612 (0.7); 0.601 (0.8); 0.504 (1.2); 0.494 (1.3); 0.491 (1.3); 0.483 (1.3); 0.480 (1.3); 0.472 (1.1); 0.469 (1.1); 0.458 (0.8); 0.000 (7.3); 0.007 (0.4)

    Example I-136

    [0510] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.708 (15.0); 7.660 (0.6); 7.656 (0.6); 7.641 (15.5); 7.357 (1.3); 7.351 (1.5); 7.339 (1.5); 7.332 (3.3); 7.325 (2.7); 7.306 (3.8); 7.300 (6.2); 7.287 (3.5); 7.282 (4.1); 7.263 (4.8); 7.258 (4.9); 7.238 (3.9); 7.232 (3.0); 7.174 (4.8); 7.170 (5.2); 7.146 (11.4); 7.120 (6.3); 7.114 (4.8); 7.086 (3.0); 4.448 (0.3); 4.438 (0.4); 4.250 (3.1); 4.202 (12.3); 4.173 (12.9); 4.125 (3.3); 3.137 (4.4); 3.134 (4.2); 3.091 (6.6); 3.088 (6.4); 2.927 (6.3); 2.923 (6.3); 2.882 (4.1); 2.877 (4.2); 2.113 (3.7); 2.069 (1.1); 2.047 (0.4); 2.031 (16.0); 1.987 (1.2); 1.966 (0.6); 1.284 (0.3); 0.981 (0.9); 0.963 (2.0); 0.953 (2.2); 0.945 (1.5); 0.936 (4.1); 0.926 (1.6); 0.918 (2.4); 0.908 (2.4); 0.890 (1.2); 0.368 (1.0); 0.353 (1.4); 0.349 (1.3); 0.337 (2.5); 0.322 (3.3); 0.308 (2.6); 0.305 (2.8); 0.294 (2.1); 0.290 (2.0); 0.275 (1.8); 0.259 (1.7); 0.245 (2.2); 0.241 (2.1); 0.231 (2.5); 0.227 (2.8); 0.214 (3.1); 0.200 (2.7); 0.187 (1.2); 0.183 (1.2); 0.169 (1.2); 0.054 (1.3); 0.037 (2.6); 0.027 (3.9); 0.022 (3.9); 0.004 (4.6); 0.011 (3.6); 0.028 (1.6); 0.083 (1.6); 0.101 (3.2); 0.115 (3.9); 0.133 (3.2); 0.147 (2.0); 0.165 (0.9)

    Example I-137

    [0511] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.796 (14.3); 7.644 (0.5); 7.632 (16.0); 7.629 (15.4); 7.446 (0.4); 7.443 (0.5); 7.397 (0.4); 7.341 (1.2); 7.334 (1.5); 7.323 (1.5); 7.316 (3.2); 7.309 (2.8); 7.298 (8.0); 7.290 (3.9); 7.283 (2.6); 7.272 (2.2); 7.265 (2.4); 7.254 (2.0); 7.248 (2.2); 7.229 (5.0); 7.222 (4.7); 7.204 (4.0); 7.197 (3.1); 7.169 (5.0); 7.165 (5.9); 7.144 (5.6); 7.140 (6.9); 7.131 (4.4); 7.119 (2.5); 7.115 (2.7); 7.104 (3.4); 7.098 (4.7); 7.094 (3.6); 7.070 (2.9); 7.066 (2.6); 4.291 (0.4); 4.234 (0.4); 4.112 (5.2); 4.064 (10.5); 3.976 (10.1); 3.928 (5.1); 2.960 (4.3); 2.956 (4.3); 2.913 (6.0); 2.909 (6.2); 2.698 (6.1); 2.694 (6.2); 2.667 (0.8); 2.652 (4.8); 2.647 (5.1); 2.634 (1.6); 2.617 (2.1); 2.611 (2.2); 2.602 (1.8); 2.583 (2.1); 2.563 (0.5); 2.553 (0.9); 2.412 (8.9); 2.403 (9.1); 2.035 (0.5); 1.953 (0.4); 1.943 (1.1); 1.913 (1.9); 1.898 (2.4); 1.882 (5.1); 1.874 (6.7); 1.864 (7.1); 1.857 (8.5); 1.850 (13.3); 1.837 (6.0); 1.827 (4.1); 1.812 (2.7); 1.801 (2.5); 1.791 (1.0); 1.777 (1.2); 1.744 (0.5); 1.730 (0.5); 1.713 (0.9); 1.699 (0.9); 1.683 (1.7); 1.672 (3.3); 1.661 (2.1); 1.652 (1.7); 1.633 (0.9); 1.623 (0.7); 1.618 (0.7); 1.610 (0.6); 1.594 (1.1); 1.590 (1.0); 1.580 (1.4); 1.570 (1.9); 1.564 (1.9); 1.557 (2.2); 1.544 (1.8); 1.537 (2.3); 1.523 (0.7); 1.513 (1.1); 0.102 (0.7); 0.029 (5.6)

    Example I-138

    [0512] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.694 (1.1); 7.583 (1.3); 7.580 (1.2); 7.300 (0.9); 7.239 (0.3); 7.082 (0.4); 7.057 (0.7); 7.053 (0.9); 7.034 (0.6); 7.031 (0.6); 7.028 (0.7); 7.011 (0.3); 7.005 (0.3); 4.358 (0.5); 4.310 (0.8); 4.144 (0.6); 4.142 (0.6); 4.096 (0.4); 4.093 (0.4); 3.253 (0.4); 3.249 (0.4); 3.204 (0.4); 3.200 (0.4); 2.786 (0.5); 2.738 (0.4); 2.403 (0.5); 2.381 (0.5); 1.094 (16.0); 0.035 (0.9)

    Example I-139

    [0513] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.801 (4.4); 7.631 (4.7); 7.351 (0.3); 7.344 (0.4); 7.333 (0.4); 7.326 (0.9); 7.319 (0.9); 7.308 (0.7); 7.298 (2.5); 7.293 (0.8); 7.282 (0.6); 7.275 (0.7); 7.270 (0.6); 7.264 (0.7); 7.245 (1.5); 7.239 (1.4); 7.220 (1.2); 7.214 (0.9); 7.180 (1.4); 7.176 (1.7); 7.155 (1.7); 7.151 (2.3); 7.130 (0.7); 7.126 (0.8); 7.120 (1.0); 7.114 (1.4); 7.086 (0.9); 7.083 (0.8); 4.320 (2.1); 4.271 (2.9); 4.001 (2.7); 3.953 (2.0); 3.063 (1.3); 3.059 (1.3); 3.016 (1.8); 3.012 (1.8); 2.729 (1.9); 2.682 (1.5); 2.299 (1.3); 2.289 (1.8); 1.844 (0.6); 1.746 (0.4); 1.723 (1.0); 1.700 (1.4); 1.677 (1.2); 1.654 (0.5); 1.342 (0.5); 1.320 (0.5); 1.134 (9.0); 1.112 (16.0); 1.089 (8.6); 0.030 (1.4)

    Example I-140

    [0514] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.035 (1.8); 8.033 (1.8); 7.853 (1.8); 7.851 (1.7); 7.446 (0.5); 7.440 (0.7); 7.415 (0.4); 7.324 (0.4); 7.320 (0.4); 7.304 (0.4); 7.296 (0.5); 7.212 (0.5); 7.183 (1.0); 7.161 (0.8); 7.157 (0.8); 7.136 (0.4); 4.743 (2.4); 4.248 (0.6); 4.201 (1.0); 4.078 (0.9); 4.030 (0.6); 3.351 (11.6); 3.054 (0.5); 3.008 (0.7); 2.697 (0.6); 2.650 (0.5); 2.537 (0.7); 2.531 (1.3); 2.525 (1.8); 2.519 (1.3); 2.513 (0.6); 1.478 (0.5); 1.429 (0.9); 1.333 (0.9); 1.283 (0.5); 0.961 (16.0); 0.889 (1.3); 0.763 (0.7); 0.022 (0.8)

    Example I-141

    [0515] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.834 (14.4); 7.701 (0.5); 7.699 (0.4); 7.670 (16.0); 7.668 (13.6); 7.507 (0.6); 7.446 (0.7); 7.443 (0.6); 7.355 (1.2); 7.349 (1.6); 7.337 (2.0); 7.330 (3.2); 7.323 (2.9); 7.310 (2.7); 7.300 (13.2); 7.286 (3.8); 7.280 (3.9); 7.263 (5.1); 7.256 (4.5); 7.237 (3.8); 7.231 (2.9); 7.185 (4.7); 7.182 (5.4); 7.161 (5.7); 7.157 (7.2); 7.151 (4.7); 7.136 (2.5); 7.132 (2.8); 7.124 (3.7); 7.118 (5.0); 7.090 (3.0); 7.087 (2.6); 5.096 (0.4); 4.889 (0.4); 4.461 (0.7); 4.413 (0.7); 4.314 (5.5); 4.266 (9.3); 4.134 (9.8); 4.086 (5.9); 3.154 (4.6); 3.150 (4.5); 3.107 (5.9); 3.104 (5.9); 2.823 (5.8); 2.819 (5.8); 2.776 (4.4); 2.773 (4.4); 2.392 (8.0); 2.079 (0.4); 2.042 (13.0); 1.724 (11.6); 1.622 (3.2); 1.601 (3.4); 1.574 (4.2); 1.553 (4.4); 1.326 (0.8); 1.293 (0.3); 1.275 (4.3); 1.251 (4.8); 1.227 (3.3); 1.203 (3.7); 0.881 (0.6); 0.873 (0.8); 0.855 (1.8); 0.845 (1.4); 0.835 (2.1); 0.830 (2.2); 0.820 (1.4); 0.811 (2.0); 0.792 (1.0); 0.785 (0.9); 0.768 (0.4); 0.670 (0.4); 0.653 (2.7); 0.636 (7.8); 0.625 (4.4); 0.614 (6.8); 0.597 (2.5); 0.161 (0.3); 0.140 (3.1); 0.126 (7.7); 0.122 (6.7); 0.110 (8.3); 0.095 (2.4); 0.079 (0.4); 0.074 (0.5); 0.044 (0.5); 0.034 (8.8); 0.023 (0.4)

    Example I-142

    [0516] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.885 (8.5); 7.658 (7.7); 7.300 (2.6); 7.238 (1.5); 7.214 (3.7); 7.197 (3.8); 7.175 (2.2); 7.109 (3.7); 7.084 (4.4); 7.059 (1.7); 4.737 (4.8); 4.689 (5.7); 4.195 (5.3); 4.146 (4.5); 3.329 (0.4); 3.281 (11.9); 3.233 (0.3); 2.539 (1.1); 2.528 (1.4); 2.514 (2.5); 2.502 (1.2); 2.488 (1.7); 2.325 (16.0); 2.319 (16.0); 2.036 (2.7); 0.766 (1.1); 0.753 (1.1); 0.747 (2.3); 0.724 (2.5); 0.720 (2.4); 0.716 (2.6); 0.694 (2.3); 0.688 (2.6); 0.676 (2.6); 0.665 (4.4); 0.660 (3.5); 0.646 (2.8); 0.638 (4.7); 0.629 (2.7); 0.619 (1.4); 0.611 (1.8); 0.585 (0.5); 0.559 (2.1); 0.556 (2.2); 0.550 (2.2); 0.528 (3.0); 0.519 (1.3); 0.507 (1.4); 0.478 (0.3); 0.030 (2.3)

    Example I-143

    [0517] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.732 (7.7); 7.729 (8.0); 7.300 (1.2); 7.265 (1.4); 7.240 (2.8); 7.221 (1.6); 7.216 (1.6); 7.175 (1.2); 7.153 (2.7); 7.128 (1.8); 7.063 (3.8); 7.038 (5.2); 7.013 (2.0); 6.933 (7.9); 6.930 (8.1); 5.318 (0.9); 4.460 (4.2); 4.411 (6.7); 4.262 (6.4); 4.213 (4.0); 3.300 (2.2); 3.296 (2.3); 3.253 (3.9); 3.249 (4.0); 3.136 (4.2); 3.091 (2.3); 3.088 (2.3); 2.887 (2.6); 2.865 (2.6); 2.301 (15.6); 2.294 (16.0); 2.066 (1.3); 1.307 (0.7); 1.292 (1.2); 1.283 (1.6); 1.259 (0.4); 0.930 (0.4); 0.909 (1.3); 0.885 (0.5); 0.807 (0.9); 0.792 (1.5); 0.780 (2.3); 0.767 (3.1); 0.760 (3.4); 0.745 (12.9); 0.735 (5.4); 0.713 (3.0); 0.707 (4.7); 0.697 (2.7); 0.689 (2.4); 0.682 (1.5); 0.668 (1.6); 0.651 (0.9); 0.634 (0.4); 0.028 (1.0)

    Example I-144

    [0518] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.759 (4.9); 7.655 (4.5); 7.300 (2.1); 7.199 (0.3); 7.176 (0.8); 7.172 (1.0); 7.153 (0.8); 7.146 (1.2); 7.139 (0.8); 7.131 (0.9); 7.122 (0.8); 7.114 (1.6); 7.106 (1.1); 7.103 (1.1); 7.089 (1.2); 7.079 (0.6); 7.076 (0.6); 7.060 (0.6); 7.030 (0.8); 7.025 (1.2); 7.010 (0.9); 7.005 (1.4); 7.000 (1.4); 6.987 (0.5); 6.980 (0.7); 6.975 (0.4); 4.441 (2.4); 4.393 (3.3); 4.167 (3.2); 4.119 (2.3); 3.246 (1.4); 3.241 (1.4); 3.199 (2.0); 3.194 (2.0); 2.983 (2.1); 2.978 (2.1); 2.936 (1.5); 2.931 (1.5); 1.853 (1.1); 1.846 (1.1); 1.369 (16.0); 0.270 (0.4); 0.243 (5.9); 0.220 (0.6); 0.203 (0.4); 0.124 (0.8); 0.089 (3.1); 0.061 (2.6); 0.030 (2.2)

    Example I-145

    [0519] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.897 (8.2); 7.683 (8.5); 7.453 (1.4); 7.448 (1.5); 7.426 (2.6); 7.423 (2.7); 7.402 (1.7); 7.397 (1.9); 7.376 (1.4); 7.371 (1.4); 7.350 (3.0); 7.329 (2.0); 7.323 (1.6); 7.300 (7.0); 7.180 (2.7); 7.177 (2.4); 7.154 (4.0); 7.128 (1.7); 7.125 (1.5); 4.753 (4.7); 4.704 (5.6); 4.241 (5.5); 4.192 (4.7); 4.165 (0.7); 4.141 (0.7); 3.406 (1.7); 3.401 (1.7); 3.359 (3.7); 3.354 (3.7); 3.280 (3.8); 3.275 (3.8); 3.232 (1.8); 3.227 (1.8); 2.353 (2.4); 2.333 (2.8); 2.078 (3.2); 2.043 (16.0); 1.739 (0.7); 1.316 (0.9); 1.292 (1.7); 1.269 (0.8); 0.782 (0.7); 0.773 (0.8); 0.765 (1.0); 0.762 (0.8); 0.747 (2.0); 0.731 (2.3); 0.721 (2.7); 0.711 (2.8); 0.702 (2.6); 0.698 (2.6); 0.689 (1.4); 0.675 (1.2); 0.663 (1.1); 0.654 (2.1); 0.648 (0.5); 0.638 (2.3); 0.628 (1.2); 0.609 (2.2); 0.601 (0.6); 0.593 (2.8); 0.589 (2.6); 0.580 (2.5); 0.563 (2.6); 0.554 (2.3); 0.541 (1.9); 0.530 (1.5); 0.519 (0.9); 0.511 (0.9); 0.502 (0.8); 0.033 (6.5)

    Example I-146

    [0520] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.894 (13.3); 7.668 (16.0); 7.298 (7.4); 7.237 (1.0); 7.230 (1.3); 7.225 (1.3); 7.214 (2.6); 7.205 (4.7); 7.194 (6.9); 7.177 (9.3); 7.170 (9.4); 7.153 (8.2); 7.145 (3.5); 7.131 (2.6); 7.125 (1.5); 7.118 (0.9); 7.102 (0.7); 4.755 (8.5); 4.706 (10.1); 4.231 (9.6); 4.182 (8.1); 3.409 (3.0); 3.404 (3.0); 3.361 (6.6); 3.357 (6.7); 3.289 (7.2); 3.285 (7.3); 3.242 (3.2); 3.237 (3.3); 2.424 (3.7); 2.038 (9.5); 0.778 (2.3); 0.769 (1.7); 0.757 (5.0); 0.735 (3.9); 0.725 (6.1); 0.712 (4.2); 0.700 (4.0); 0.695 (4.6); 0.682 (4.3); 0.669 (1.2); 0.660 (6.1); 0.648 (5.4); 0.625 (4.3); 0.612 (4.3); 0.607 (4.0); 0.595 (3.2); 0.563 (5.1); 0.552 (4.1); 0.530 (5.5); 0.518 (2.0); 0.508 (2.5); 0.476 (0.4); 0.029 (7.2)

    Example I-147

    [0521] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.752 (15.2); 7.461 (0.7); 7.367 (1.0); 7.348 (0.5); 7.339 (0.4); 7.321 (0.5); 7.300 (14.9); 7.234 (3.0); 7.209 (7.0); 7.184 (5.1); 7.181 (5.2); 7.157 (4.7); 7.148 (6.2); 7.141 (8.2); 7.127 (6.1); 7.122 (9.1); 7.118 (6.8); 7.099 (3.8); 7.097 (3.8); 7.086 (1.8); 7.069 (1.5); 7.036 (0.6); 7.020 (1.0); 6.979 (15.9); 6.935 (0.6); 6.910 (0.4); 6.782 (0.6); 5.319 (2.3); 5.058 (0.4); 4.828 (0.4); 4.761 (0.3); 4.712 (0.7); 4.645 (0.7); 4.488 (9.2); 4.439 (15.7); 4.393 (0.4); 4.355 (0.4); 4.312 (15.1); 4.263 (8.8); 3.526 (0.6); 3.503 (0.4); 3.480 (0.4); 3.402 (5.7); 3.398 (5.7); 3.355 (8.0); 3.350 (8.0); 3.132 (8.5); 3.127 (8.4); 3.084 (6.0); 3.080 (6.0); 2.419 (3.4); 1.842 (0.6); 1.824 (1.3); 1.812 (1.7); 1.796 (1.8); 1.785 (1.8); 1.575 (0.4); 1.560 (0.9); 1.548 (0.8); 1.331 (0.4); 1.290 (1.4); 1.267 (0.7); 1.244 (1.0); 1.220 (0.5); 1.133 (2.6); 0.940 (0.5); 0.917 (1.2); 0.894 (0.6); 0.863 (1.0); 0.846 (2.7); 0.826 (3.2); 0.823 (3.3); 0.811 (8.1); 0.801 (6.0); 0.793 (7.0); 0.782 (12.0); 0.778 (9.6); 0.761 (16.0); 0.742 (7.3); 0.727 (4.3); 0.706 (3.2); 0.698 (4.9); 0.679 (4.9); 0.674 (3.5); 0.669 (5.1); 0.662 (4.9); 0.656 (3.7); 0.637 (3.2); 0.620 (1.7); 0.035 (12.0)

    Example I-148

    [0522] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.801 (15.8); 7.659 (16.0); 7.657 (15.8); 7.298 (18.4); 7.186 (1.0); 7.180 (1.1); 7.159 (2.6); 7.153 (3.1); 7.148 (1.5); 7.135 (2.8); 7.127 (4.3); 7.120 (5.1); 7.103 (5.7); 7.097 (6.1); 7.078 (4.2); 7.070 (1.7); 7.066 (1.9); 7.050 (1.8); 7.016 (2.4); 7.011 (3.5); 6.991 (3.7); 6.986 (4.4); 6.974 (1.5); 6.966 (2.0); 4.168 (0.5); 4.144 (0.6); 4.125 (5.4); 4.077 (11.5); 3.997 (11.5); 3.949 (5.5); 2.995 (4.7); 2.990 (4.8); 2.949 (6.3); 2.943 (6.5); 2.702 (6.4); 2.697 (7.0); 2.667 (2.8); 2.656 (5.7); 2.650 (5.8); 2.641 (3.1); 2.619 (1.4); 2.610 (2.3); 2.581 (0.8); 2.147 (3.6); 2.138 (3.8); 2.080 (2.3); 1.935 (0.6); 1.907 (1.9); 1.884 (9.6); 1.874 (10.0); 1.869 (9.1); 1.859 (12.9); 1.834 (4.5); 1.804 (3.3); 1.776 (1.5); 1.731 (1.2); 1.721 (1.6); 1.709 (1.8); 1.689 (3.1); 1.673 (5.9); 1.665 (5.6); 1.660 (3.8); 1.645 (1.7); 1.633 (2.1); 1.618 (2.7); 1.612 (2.8); 1.593 (2.4); 1.587 (2.4); 1.555 (1.0); 1.538 (0.5); 1.452 (0.6); 1.439 (1.2); 1.327 (2.3); 1.318 (2.8); 1.294 (8.1); 1.270 (2.4); 1.208 (0.7); 1.097 (0.7); 1.068 (0.7); 1.012 (0.4); 0.937 (1.8); 0.916 (5.1); 0.889 (5.5); 0.863 (5.1); 0.299 (0.3); 0.121 (1.4); 0.117 (3.3); 0.105 (85.0); 0.092 (3.4); 0.080 (0.9); 0.045 (0.7); 0.034 (17.3); 0.024 (0.8); 0.094 (0.3)

    Example I-149

    [0523] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.821 (5.2); 7.685 (5.6); 7.682 (5.7); 7.298 (22.5); 7.203 (0.3); 7.197 (0.4); 7.175 (0.9); 7.169 (1.1); 7.164 (0.5); 7.152 (1.0); 7.144 (1.5); 7.137 (1.8); 7.121 (1.3); 7.118 (1.9); 7.113 (2.2); 7.109 (1.5); 7.095 (1.3); 7.092 (1.4); 7.085 (0.6); 7.081 (0.6); 7.065 (0.6); 7.016 (1.2); 6.997 (1.3); 6.991 (1.5); 6.979 (0.5); 6.972 (0.7); 4.327 (2.5); 4.279 (3.4); 4.035 (3.3); 3.987 (2.4); 3.120 (1.6); 3.115 (1.7); 3.073 (2.0); 3.068 (2.1); 2.727 (2.0); 2.722 (2.1); 2.680 (1.6); 2.675 (1.7); 1.897 (3.4); 1.890 (3.5); 1.757 (0.4); 1.735 (1.2); 1.712 (1.7); 1.689 (1.4); 1.666 (0.6); 1.602 (16.0); 1.147 (11.2); 1.132 (12.6); 1.125 (11.4); 1.109 (10.9); 0.048 (0.8); 0.037 (23.6); 0.026 (0.9)

    Example I-150

    [0524] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.024 (1.7); 8.022 (1.6); 7.853 (1.8); 7.850 (1.7); 7.708 (0.5); 7.327 (0.4); 7.300 (0.3); 7.292 (0.4); 7.265 (0.4); 7.258 (0.5); 7.254 (0.5); 7.234 (0.4); 7.171 (0.4); 7.166 (0.4); 7.162 (0.4); 7.145 (0.4); 4.783 (2.5); 4.288 (0.6); 4.240 (0.9); 4.092 (0.9); 4.044 (0.6); 3.349 (4.5); 3.103 (0.5); 3.058 (0.6); 2.728 (0.6); 2.683 (0.4); 2.537 (0.4); 2.531 (0.8); 2.525 (1.1); 2.519 (0.8); 2.513 (0.4); 2.098 (0.4); 1.482 (0.4); 1.432 (1.0); 1.374 (1.0); 1.325 (0.4); 0.973 (16.0); 0.787 (1.4); 0.021 (0.6)

    Example I-151

    [0525] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.837 (3.9); 7.691 (4.3); 7.688 (4.1); 7.300 (8.6); 7.169 (0.6); 7.163 (0.8); 7.157 (0.4); 7.146 (0.7); 7.138 (1.1); 7.130 (1.3); 7.114 (1.4); 7.107 (1.6); 7.090 (1.2); 7.081 (0.5); 7.078 (0.6); 7.062 (0.6); 7.050 (0.7); 7.045 (0.9); 7.026 (0.9); 7.020 (1.0); 7.008 (0.4); 7.001 (0.4); 4.317 (1.4); 4.269 (2.5); 4.151 (2.8); 4.103 (1.6); 3.181 (1.2); 3.175 (1.2); 3.134 (1.6); 3.129 (1.6); 2.825 (1.5); 2.820 (1.5); 2.779 (1.2); 2.773 (1.2); 2.284 (3.5); 2.047 (1.0); 1.641 (16.0); 1.632 (1.1); 1.611 (1.0); 1.583 (1.2); 1.563 (1.2); 1.292 (1.2); 1.268 (1.3); 1.244 (0.9); 1.220 (1.0); 0.837 (0.5); 0.828 (0.4); 0.812 (0.6); 0.803 (0.4); 0.792 (0.5); 0.671 (0.9); 0.654 (2.2); 0.645 (1.0); 0.640 (1.2); 0.631 (1.9); 0.626 (1.5); 0.614 (0.7); 0.152 (0.8); 0.136 (2.2); 0.121 (2.4); 0.106 (0.6); 0.036 (6.3)

    Example I-152

    [0526] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.204 (8.7); 8.188 (9.1); 7.886 (16.0); 7.689 (0.6); 7.668 (14.8); 7.464 (5.4); 7.448 (10.4); 7.431 (5.2); 7.300 (5.1); 4.745 (7.6); 4.696 (9.4); 4.324 (9.6); 4.275 (7.9); 3.477 (4.9); 3.430 (7.2); 3.409 (0.3); 3.283 (1.9); 3.249 (7.9); 3.202 (4.9); 2.136 (0.7); 2.039 (15.8); 1.017 (0.4); 0.767 (1.1); 0.763 (1.2); 0.754 (1.2); 0.741 (3.5); 0.719 (4.8); 0.712 (7.5); 0.704 (6.5); 0.686 (3.6); 0.659 (3.9); 0.646 (4.4); 0.613 (3.0); 0.605 (3.9); 0.601 (3.8); 0.595 (3.1); 0.585 (1.1); 0.557 (1.5); 0.549 (3.4); 0.542 (3.4); 0.525 (3.9); 0.507 (1.8); 0.499 (1.8); 0.493 (1.6); 0.021 (4.0)

    Example I-153

    [0527] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.878 (4.4); 7.677 (4.3); 7.345 (0.8); 7.326 (1.0); 7.317 (1.3); 7.300 (3.4); 6.983 (2.8); 6.954 (3.1); 6.931 (0.8); 6.922 (0.4); 4.680 (2.4); 4.631 (3.0); 4.310 (2.9); 4.262 (2.2); 4.164 (0.5); 4.140 (0.6); 3.480 (2.2); 3.433 (2.6); 3.012 (2.8); 2.964 (2.4); 2.313 (16.0); 2.077 (2.5); 1.849 (0.8); 1.835 (1.0); 1.813 (0.4); 1.719 (0.4); 1.316 (0.7); 1.292 (1.4); 1.268 (0.7); 0.927 (0.7); 0.918 (0.8); 0.914 (0.8); 0.905 (0.6); 0.889 (0.9); 0.884 (1.2); 0.878 (1.3); 0.873 (1.1); 0.772 (0.7); 0.763 (1.1); 0.759 (1.2); 0.750 (1.0); 0.734 (0.5); 0.729 (0.6); 0.723 (0.8); 0.717 (0.8); 0.647 (1.0); 0.611 (3.3); 0.603 (3.8); 0.596 (2.3); 0.591 (2.8); 0.556 (0.4); 0.033 (2.8)

    Example I-154

    [0528] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.881 (12.7); 7.671 (13.0); 7.553 (4.4); 7.533 (4.6); 7.524 (5.2); 7.504 (4.8); 7.300 (4.6); 7.224 (4.6); 7.215 (5.2); 7.196 (4.6); 7.188 (5.1); 7.097 (3.0); 7.089 (2.7); 7.071 (3.9); 7.069 (4.0); 7.062 (3.6); 7.061 (3.5); 7.043 (2.7); 7.034 (2.3); 4.741 (7.7); 4.692 (9.3); 4.242 (9.1); 4.193 (7.6); 3.456 (1.2); 3.408 (14.2); 3.401 (15.3); 3.352 (1.2); 2.504 (16.0); 2.037 (1.5); 1.835 (0.9); 0.859 (0.4); 0.829 (1.5); 0.824 (1.9); 0.816 (2.0); 0.806 (3.2); 0.803 (3.1); 0.793 (1.1); 0.782 (3.5); 0.770 (4.7); 0.739 (3.1); 0.727 (3.2); 0.721 (4.0); 0.706 (4.1); 0.683 (4.8); 0.674 (4.7); 0.670 (3.2); 0.659 (1.6); 0.649 (3.9); 0.635 (4.2); 0.630 (3.7); 0.617 (3.5); 0.595 (4.9); 0.583 (3.5); 0.563 (4.5); 0.549 (1.9); 0.540 (1.9); 0.537 (1.7); 0.506 (0.3); 0.029 (3.8)

    Example I-155

    [0529] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.759 (4.0); 7.757 (3.9); 7.362 (1.0); 7.354 (0.5); 7.342 (1.4); 7.331 (1.5); 7.312 (1.4); 7.300 (10.8); 7.007 (4.4); 7.004 (4.2); 6.960 (2.8); 6.930 (2.5); 6.921 (1.3); 6.910 (1.0); 6.900 (0.4); 5.338 (6.6); 4.363 (11.2); 3.427 (2.4); 3.380 (2.8); 2.896 (3.1); 2.848 (2.6); 2.238 (16.0); 2.083 (0.8); 1.653 (0.6); 1.592 (2.3); 1.297 (0.9); 1.292 (0.8); 0.960 (0.4); 0.937 (0.5); 0.927 (1.1); 0.920 (0.8); 0.900 (4.1); 0.894 (2.7); 0.884 (1.7); 0.875 (2.4); 0.868 (0.9); 0.858 (1.1); 0.852 (0.9); 0.842 (1.3); 0.834 (1.9); 0.817 (1.1); 0.810 (1.3); 0.794 (0.7); 0.686 (1.2); 0.673 (1.3); 0.660 (0.9); 0.653 (1.1); 0.649 (0.8); 0.638 (1.0); 0.632 (1.0); 0.629 (0.7); 0.049 (0.4); 0.038 (10.2); 0.027 (0.5)

    Example I-156

    [0530] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.880 (16.0); 7.701 (0.4); 7.677 (14.3); 7.300 (5.3); 6.980 (0.6); 6.973 (1.3); 6.957 (6.1); 6.950 (8.5); 6.930 (8.1); 6.923 (6.8); 6.908 (1.4); 6.900 (0.7); 6.848 (1.7); 6.841 (2.5); 6.833 (1.3); 6.818 (3.4); 6.811 (4.9); 6.803 (2.3); 6.789 (1.8); 6.781 (2.5); 6.774 (1.2); 4.656 (7.2); 4.607 (9.8); 4.355 (9.7); 4.306 (7.2); 3.533 (6.4); 3.487 (7.3); 2.828 (8.1); 2.782 (7.1); 2.733 (0.7); 2.041 (3.0); 1.990 (0.4); 1.961 (0.4); 0.777 (0.9); 0.762 (1.0); 0.757 (1.1); 0.743 (2.4); 0.727 (4.1); 0.714 (7.5); 0.704 (5.4); 0.684 (3.2); 0.669 (1.4); 0.650 (1.6); 0.604 (0.8); 0.570 (1.9); 0.560 (2.1); 0.554 (1.9); 0.541 (4.0); 0.524 (4.2); 0.519 (4.1); 0.504 (3.3); 0.464 (3.2); 0.449 (3.7); 0.429 (2.6); 0.422 (1.8); 0.413 (2.2); 0.400 (1.3); 0.029 (4.8)

    Example I-157

    [0531] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.878 (15.2); 7.681 (16.0); 7.345 (6.9); 7.338 (3.3); 7.327 (7.9); 7.316 (9.4); 7.299 (13.4); 7.129 (1.3); 7.120 (9.2); 7.113 (3.0); 7.091 (16.0); 7.069 (2.8); 7.062 (7.1); 7.052 (0.9); 4.659 (7.9); 4.645 (0.5); 4.611 (10.6); 4.343 (10.7); 4.295 (8.1); 3.557 (7.9); 3.510 (8.8); 2.788 (8.7); 2.741 (7.8); 2.209 (9.6); 2.039 (2.8); 1.285 (1.0); 0.763 (1.4); 0.746 (1.1); 0.740 (1.5); 0.727 (3.6); 0.711 (4.8); 0.705 (5.9); 0.697 (11.9); 0.689 (6.5); 0.668 (4.5); 0.654 (1.5); 0.650 (1.4); 0.633 (2.2); 0.578 (0.9); 0.543 (2.2); 0.535 (2.7); 0.529 (2.5); 0.516 (4.1); 0.499 (3.8); 0.494 (3.8); 0.477 (2.9); 0.378 (3.5); 0.361 (4.1); 0.357 (3.9); 0.340 (3.2); 0.334 (2.3); 0.325 (3.1); 0.322 (2.9); 0.313 (1.8); 0.279 (0.4); 0.031 (5.4)

    Example I-158

    [0532] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =7.757 (12.7); 7.421 (6.1); 7.402 (8.3); 7.393 (8.9); 7.374 (7.3); 7.312 (0.6); 7.296 (0.6); 7.286 (0.6); 7.274 (0.7); 7.245 (0.7); 7.148 (7.6); 7.118 (12.4); 7.089 (6.0); 6.986 (11.9); 5.298 (16.0); 5.254 (0.6); 5.215 (0.4); 4.388 (5.2); 4.339 (8.3); 4.194 (8.2); 4.145 (5.3); 3.930 (0.4); 3.346 (27.3); 3.196 (5.6); 3.150 (6.8); 2.913 (1.9); 2.882 (0.6); 2.868 (0.6); 2.853 (0.3); 2.781 (6.5); 2.754 (2.4); 2.734 (5.3); 2.525 (20.5); 0.617 (2.1); 0.575 (5.7); 0.564 (5.3); 0.556 (5.8); 0.543 (5.2); 0.522 (4.6); 0.505 (4.2); 0.484 (3.7); 0.472 (3.1); 0.459 (4.1); 0.444 (3.5); 0.431 (4.0); 0.417 (2.3); 0.401 (1.9); 0.382 (1.0); 0.062 (0.3); 0.023 (20.6)

    Example I-159

    [0533] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.838 (1.2); 7.799 (5.3); 7.655 (1.5); 7.635 (5.8); 7.622 (2.8); 7.606 (2.6); 7.467 (0.3); 7.260 (52.3); 7.215 (3.2); 7.204 (3.9); 7.198 (4.3); 7.187 (3.8); 7.143 (0.8); 7.132 (1.0); 7.126 (1.2); 7.114 (1.7); 7.102 (1.6); 7.096 (1.9); 7.085 (1.7); 7.070 (3.9); 7.053 (6.7); 7.036 (3.5); 7.015 (3.3); 6.998 (3.5); 6.980 (1.3); 5.299 (0.7); 4.742 (5.7); 4.478 (4.5); 4.460 (3.7); 4.431 (4.3); 4.180 (0.7); 4.173 (0.4); 4.152 (1.1); 4.141 (4.0); 4.112 (3.4); 4.022 (1.0); 3.994 (0.7); 3.656 (0.7); 3.164 (3.4); 3.135 (3.9); 2.963 (0.9); 2.945 (2.1); 2.928 (2.1); 2.911 (1.2); 2.875 (0.8); 2.847 (0.9); 2.745 (3.8); 2.717 (3.4); 2.555 (1.4); 2.538 (1.7); 2.530 (1.1); 2.526 (1.1); 2.513 (1.8); 2.494 (1.0); 2.392 (0.7); 2.374 (1.6); 2.367 (1.0); 2.354 (1.2); 2.348 (1.9); 2.330 (1.3); 2.300 (0.6); 2.279 (4.6); 2.264 (2.0); 2.242 (1.9); 2.224 (1.2); 2.205 (0.5); 2.106 (0.6); 2.089 (1.5); 2.074 (2.2); 2.058 (1.5); 2.042 (0.6); 2.006 (0.3); 1.975 (0.5); 1.958 (1.2); 1.950 (1.1); 1.941 (1.6); 1.932 (1.4); 1.925 (1.5); 1.916 (1.1); 1.908 (0.8); 1.811 (0.9); 1.801 (1.0); 1.794 (1.3); 1.786 (1.4); 1.776 (1.2); 1.769 (1.1); 1.759 (1.0); 1.751 (0.7); 1.742 (0.7); 1.733 (0.6); 1.717 (0.5); 1.703 (0.9); 1.697 (0.7); 1.685 (1.9); 1.681 (1.6); 1.663 (2.3); 1.657 (2.0); 1.645 (1.6); 1.626 (1.0); 1.569 (6.6); 1.493 (1.0); 1.481 (0.9); 1.474 (0.9); 1.333 (0.5); 1.255 (16.0); 1.158 (0.7); 1.146 (0.7); 1.103 (0.6); 0.894 (1.1); 0.880 (1.6); 0.867 (0.9); 0.859 (0.5); 0.841 (0.6); 0.831 (0.6); 0.730 (0.3); 0.715 (0.5); 0.000 (51.3)

    Example I-160

    [0534] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =7.920 (13.7); 7.771 (14.5); 7.311 (5.8); 7.297 (7.3); 7.290 (8.0); 7.275 (6.6); 7.122 (7.4); 7.100 (12.3); 7.078 (5.8); 5.006 (16.0); 3.978 (3.5); 3.942 (9.0); 3.905 (9.5); 3.869 (3.7); 3.323 (118.5); 2.712 (3.9); 2.677 (8.0); 2.618 (7.7); 2.584 (4.2); 2.512 (52.4); 2.507 (66.9); 2.503 (47.9); 2.436 (0.6); 2.414 (1.7); 2.395 (2.4); 2.372 (1.8); 2.350 (0.7); 2.334 (0.5); 2.006 (1.6); 1.984 (2.6); 1.961 (1.2); 1.949 (0.9); 1.748 (0.5); 1.726 (1.7); 1.703 (3.0); 1.687 (3.6); 1.680 (3.9); 1.671 (4.6); 1.654 (4.6); 1.639 (3.8); 1.619 (1.6); 1.558 (0.5); 1.536 (1.4); 1.515 (2.4); 1.497 (1.8); 1.475 (0.6); 1.350 (0.7); 1.336 (1.3); 1.324 (2.1); 1.311 (1.9); 1.298 (1.8); 1.280 (0.5)

    Example I-161

    [0535] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.829 (12.7); 7.647 (12.8); 7.261 (15.7); 7.223 (0.7); 7.144 (7.9); 7.128 (11.0); 7.117 (8.6); 7.030 (8.6); 7.013 (12.8); 6.996 (5.9); 6.969 (0.8); 4.178 (6.1); 4.149 (8.3); 4.129 (0.8); 4.114 (0.6); 4.100 (0.4); 4.020 (7.9); 3.992 (5.5); 2.976 (0.7); 2.963 (0.7); 2.875 (6.4); 2.847 (7.2); 2.554 (7.4); 2.526 (6.1); 2.043 (1.4); 1.992 (1.8); 1.975 (3.8); 1.958 (5.5); 1.940 (4.2); 1.923 (1.7); 1.878 (0.7); 1.756 (7.7); 1.742 (8.2); 1.704 (16.0); 1.671 (6.6); 1.657 (7.1); 1.647 (6.9); 1.633 (5.6); 1.615 (5.6); 1.581 (27.9); 1.480 (6.4); 1.474 (6.5); 1.272 (1.0); 1.258 (2.0); 0.882 (0.4); 0.000 (14.9)

    Example I-162

    [0536] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =7.948 (6.6); 7.809 (6.9); 7.808 (6.9); 7.335 (2.9); 7.330 (1.5); 7.321 (3.6); 7.314 (3.9); 7.305 (1.7); 7.299 (3.3); 7.101 (3.7); 7.079 (6.2); 7.062 (1.3); 7.057 (3.0); 4.806 (9.3); 4.222 (2.8); 4.186 (3.6); 3.941 (3.7); 3.905 (3.0); 3.323 (54.8); 2.843 (2.5); 2.809 (3.1); 2.554 (3.3); 2.516 (13.3); 2.512 (23.1); 2.507 (29.9); 2.503 (21.7); 2.499 (10.8); 2.079 (0.5); 1.994 (0.4); 1.525 (0.5); 1.508 (1.3); 1.491 (1.9); 1.473 (1.5); 1.456 (0.6); 0.946 (16.0); 0.929 (14.8)

    Example I-163

    [0537] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.552 (2.6); 8.546 (2.6); 8.400 (1.7); 8.384 (1.7); 8.005 (3.5); 8.003 (3.4); 7.871 (3.6); 7.868 (3.3); 7.610 (1.0); 7.593 (1.2); 7.589 (1.2); 7.572 (1.0); 5.786 (16.0); 5.693 (3.7); 4.630 (1.4); 4.581 (1.8); 4.226 (1.8); 4.177 (1.5); 3.355 (7.3); 3.265 (0.8); 3.218 (1.9); 3.162 (1.8); 3.116 (0.9); 2.540 (1.7); 2.534 (3.6); 2.528 (4.9); 2.522 (3.6); 2.516 (1.7); 2.015 (0.4); 1.081 (0.4); 0.750 (0.5); 0.745 (0.5); 0.731 (0.6); 0.726 (0.6); 0.714 (0.6); 0.709 (0.6); 0.692 (0.6); 0.655 (0.4); 0.630 (0.6); 0.620 (0.7); 0.613 (0.4); 0.596 (0.9); 0.579 (0.8); 0.560 (0.7); 0.544 (0.8); 0.538 (0.7); 0.520 (0.8); 0.510 (0.6); 0.486 (0.4); 0.477 (0.7); 0.460 (0.6); 0.454 (0.7); 0.442 (0.7); 0.425 (0.5); 0.418 (0.5); 0.026 (5.8)

    Example I-164

    [0538] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.203 (8.1); 8.186 (8.3); 7.680 (10.6); 7.646 (0.5); 7.300 (62.7); 7.284 (3.8); 7.280 (4.9); 7.056 (9.5); 6.949 (0.8); 6.929 (11.4); 4.527 (7.3); 4.478 (11.9); 4.340 (11.3); 4.290 (7.0); 3.548 (7.9); 3.503 (11.0); 2.784 (8.0); 2.739 (7.2); 1.638 (15.4); 1.592 (1.6); 1.291 (16.0); 1.186 (0.4); 1.166 (0.4); 1.139 (0.5); 0.918 (1.1); 0.894 (4.5); 0.889 (4.5); 0.862 (10.9); 0.832 (8.8); 0.775 (0.4); 0.742 (3.2); 0.722 (4.1); 0.718 (3.3); 0.707 (1.9); 0.693 (4.2); 0.683 (1.7); 0.663 (2.0); 0.608 (3.2); 0.588 (2.9); 0.580 (3.6); 0.575 (2.8); 0.557 (3.9); 0.547 (2.4); 0.527 (1.6); 0.048 (1.5); 0.037 (42.1); 0.026 (1.6)

    Example I-165

    [0539] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.268 (8.9); 7.884 (9.2); 7.691 (8.7); 7.300 (5.0); 7.226 (6.2); 7.218 (6.2); 4.766 (5.1); 4.717 (6.2); 4.291 (5.2); 4.243 (4.3); 4.158 (0.4); 4.134 (0.4); 3.526 (2.8); 3.479 (6.8); 3.421 (6.0); 3.374 (2.4); 2.773 (1.1); 2.762 (1.6); 2.722 (1.9); 2.074 (1.8); 2.042 (16.0); 1.313 (0.5); 1.289 (0.9); 1.265 (0.5); 0.892 (0.9); 0.882 (1.3); 0.875 (1.4); 0.863 (2.2); 0.858 (2.1); 0.840 (2.3); 0.825 (2.9); 0.795 (2.0); 0.779 (2.3); 0.775 (2.7); 0.759 (2.7); 0.740 (1.8); 0.731 (2.9); 0.721 (2.4); 0.714 (1.4); 0.710 (1.3); 0.691 (2.0); 0.674 (2.5); 0.658 (1.3); 0.655 (1.3); 0.612 (2.7); 0.597 (2.2); 0.582 (1.7); 0.574 (2.2); 0.562 (1.4); 0.555 (1.4); 0.545 (0.9); 0.029 (4.8)

    Example I-166

    [0540] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.916 (6.8); 7.894 (16.0); 7.683 (12.5); 7.558 (4.8); 7.553 (5.2); 7.533 (7.2); 7.528 (7.4); 7.438 (3.9); 7.413 (6.7); 7.388 (3.2); 7.300 (9.4); 7.081 (3.4); 7.076 (3.0); 7.055 (5.6); 7.030 (2.9); 7.025 (2.4); 4.742 (8.3); 4.694 (10.2); 4.295 (8.2); 4.247 (6.7); 3.634 (5.6); 3.586 (8.4); 3.408 (12.1); 3.360 (8.1); 2.289 (7.1); 2.260 (1.5); 2.219 (0.8); 2.041 (2.7); 1.736 (0.5); 1.289 (0.8); 0.924 (0.7); 0.894 (2.9); 0.883 (2.4); 0.875 (4.3); 0.870 (3.0); 0.852 (3.7); 0.847 (2.9); 0.840 (3.9); 0.812 (0.8); 0.777 (2.4); 0.767 (2.5); 0.757 (3.7); 0.746 (8.5); 0.738 (5.1); 0.726 (5.2); 0.720 (9.7); 0.707 (4.7); 0.699 (3.2); 0.686 (4.0); 0.654 (3.6); 0.647 (4.1); 0.620 (4.7); 0.613 (2.4); 0.600 (2.4); 0.584 (0.3); 0.572 (0.6); 0.106 (1.4); 0.034 (6.8)

    Example I-167

    [0541] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.892 (3.7); 7.889 (3.6); 7.866 (3.9); 7.862 (3.8); 7.778 (5.3); 7.631 (0.5); 7.593 (3.1); 7.588 (3.3); 7.568 (4.0); 7.563 (3.8); 7.511 (0.4); 7.484 (0.4); 7.413 (2.2); 7.410 (2.2); 7.388 (4.0); 7.385 (3.9); 7.363 (2.1); 7.359 (2.0); 7.329 (1.2); 7.315 (1.9); 7.300 (19.1); 7.290 (1.9); 7.265 (0.4); 7.253 (0.5); 7.241 (0.4); 7.229 (0.7); 7.211 (0.4); 7.204 (0.5); 7.185 (0.8); 7.175 (0.5); 7.162 (0.5); 7.054 (2.2); 7.048 (2.2); 7.021 (8.0); 7.003 (2.3); 6.997 (2.0); 6.973 (0.4); 6.947 (0.3); 6.910 (0.5); 6.890 (0.7); 5.338 (3.0); 4.558 (0.5); 4.521 (0.6); 4.472 (0.4); 4.459 (3.0); 4.410 (7.9); 4.356 (7.7); 4.307 (2.9); 3.615 (4.4); 3.567 (5.8); 3.346 (0.4); 3.271 (6.1); 3.223 (4.6); 3.012 (0.3); 2.994 (0.4); 2.074 (1.7); 1.825 (0.4); 1.806 (0.5); 1.763 (0.8); 1.755 (0.8); 1.744 (0.8); 1.733 (0.8); 1.520 (0.9); 1.498 (0.8); 1.471 (0.5); 1.464 (0.5); 1.293 (2.4); 1.262 (0.5); 1.215 (0.5); 1.191 (0.8); 1.172 (0.5); 1.006 (0.8); 0.918 (0.7); 0.890 (1.5); 0.867 (16.0); 0.854 (4.6); 0.837 (3.6); 0.826 (3.5); 0.813 (2.2); 0.803 (1.3); 0.755 (3.0); 0.739 (1.8); 0.721 (2.0); 0.712 (1.2); 0.038 (14.1)

    Example I-168

    [0542] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =9.221 (3.3); 9.204 (3.4); 8.065 (0.3); 7.997 (4.5); 7.937 (2.9); 7.920 (2.8); 7.870 (4.7); 7.845 (0.3); 5.786 (16.0); 5.762 (4.8); 4.668 (1.7); 4.619 (2.1); 4.213 (2.3); 4.164 (1.9); 3.354 (41.8); 3.333 (7.9); 3.290 (0.5); 2.534 (12.3); 2.528 (16.7); 2.522 (12.1); 1.355 (1.0); 1.262 (0.6); 1.081 (0.5); 0.929 (0.4); 0.907 (0.7); 0.886 (0.8); 0.872 (0.9); 0.850 (0.7); 0.790 (0.4); 0.765 (0.7); 0.755 (0.8); 0.731 (1.0); 0.712 (0.8); 0.658 (0.7); 0.640 (0.9); 0.616 (0.9); 0.606 (0.8); 0.581 (0.5); 0.564 (0.8); 0.540 (0.8); 0.528 (0.8); 0.522 (0.7); 0.505 (0.7); 0.485 (0.4); 0.037 (0.8); 0.026 (22.4); 0.015 (1.0)

    Example I-169

    [0543] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =8.012 (9.3); 7.997 (8.8); 7.387 (2.5); 7.382 (3.5); 7.360 (16.0); 7.354 (7.3); 7.345 (9.8); 7.342 (10.7); 7.335 (10.0); 7.326 (7.1); 7.319 (8.7); 7.306 (2.3); 7.300 (13.9); 7.281 (7.3); 7.275 (7.1); 7.254 (4.1); 4.718 (0.9); 4.669 (10.3); 4.661 (10.1); 4.612 (0.9); 4.200 (13.8); 4.175 (0.9); 4.126 (9.8); 4.117 (9.8); 4.068 (0.8); 3.310 (5.0); 3.265 (6.4); 2.969 (6.0); 2.924 (4.7); 1.671 (4.9); 0.623 (0.4); 0.618 (0.4); 0.608 (0.6); 0.595 (2.5); 0.580 (9.2); 0.575 (5.3); 0.567 (3.2); 0.562 (2.0); 0.557 (1.7); 0.552 (1.6); 0.547 (2.1); 0.533 (2.8); 0.524 (3.4); 0.518 (2.8); 0.512 (1.8); 0.491 (1.3); 0.485 (3.4); 0.475 (1.9); 0.453 (2.0); 0.442 (0.8); 0.042 (8.0)

    Example XVII-1

    [0544] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.427 (4.1); 7.263 (4.5); 6.995 (4.4); 6.993 (4.5); 5.278 (16.0); 1.792 (2.0); 1.782 (6.0); 1.775 (6.1); 1.765 (2.5); 1.673 (0.5); 1.526 (2.4); 1.516 (6.0); 1.509 (6.2); 1.498 (2.1); 0.000 (4.3)

    Example XVII-2

    [0545] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.701 (5.1); 7.699 (5.3); 7.587 (4.7); 7.266 (3.7); 5.451 (16.0); 2.004 (2.6); 1.841 (2.1); 1.830 (6.2); 1.823 (6.0); 1.813 (2.5); 1.643 (2.5); 1.575 (2.5); 1.565 (6.0); 1.558 (6.3); 1.547 (2.1); 0.000 (3.9)

    Example XVII-3

    [0546] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.688 (6.2); 7.627 (5.8); 7.267 (2.5); 5.299 (0.7); 5.067 (16.0); 1.998 (0.5); 1.989 (1.1); 1.982 (1.3); 1.973 (2.2); 1.965 (1.4); 1.958 (1.2); 1.949 (0.7); 1.259 (1.0); 1.251 (3.5); 1.243 (5.3); 1.235 (4.2); 1.228 (1.6); 1.207 (0.4); 1.134 (1.3); 1.127 (3.5); 1.120 (3.8); 1.112 (4.3); 1.105 (3.0); 1.097 (1.2); 0.000 (2.5)

    Example XVII-4

    [0547] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.715 (9.8); 7.622 (9.1); 7.264 (6.3); 5.383 (15.1); 5.378 (16.0); 1.641 (1.2); 1.634 (1.3); 1.623 (6.9); 1.620 (5.1); 1.610 (3.1); 1.606 (2.0); 1.599 (1.5); 1.590 (3.0); 1.583 (4.4); 1.575 (5.0); 1.566 (3.0); 1.557 (4.4); 1.549 (6.8); 1.542 (5.2); 1.535 (4.0); 1.519 (1.5); 0.006 (0.3); 0.000 (6.5)

    Example XVII-5

    [0548] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.742 (0.9); 7.738 (1.3); 7.733 (0.6); 7.722 (0.4); 7.715 (1.7); 7.710 (1.5); 7.702 (0.9); 7.698 (1.3); 7.693 (0.6); 7.682 (0.4); 7.675 (1.7); 7.670 (1.5); 7.613 (0.3); 7.608 (0.4); 7.588 (0.9); 7.583 (0.9); 7.569 (0.5); 7.564 (1.1); 7.558 (1.0); 7.553 (0.4); 7.527 (1.3); 7.522 (0.9); 7.517 (1.4); 7.513 (0.7); 7.507 (1.0); 7.502 (1.6); 7.497 (1.3); 7.492 (1.6); 7.487 (0.5); 7.479 (0.7); 7.474 (0.6); 7.469 (0.6); 7.464 (0.4); 7.300 (4.6); 7.114 (3.8); 7.112 (3.8); 6.623 (2.1); 6.620 (2.1); 6.598 (2.1); 6.595 (2.1); 5.245 (16.0); 1.845 (2.0); 1.827 (4.9); 1.815 (5.6); 1.800 (2.7); 1.744 (0.4); 1.630 (0.4); 1.574 (2.6); 1.559 (5.5); 1.547 (5.0); 1.529 (2.0); 0.033 (4.7)

    Example XVII-6

    [0549] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.796 (2.6); 7.793 (2.5); 7.567 (2.4); 7.300 (3.7); 5.647 (8.2); 3.847 (16.0); 3.521 (2.3); 1.828 (1.2); 1.810 (2.9); 1.798 (3.2); 1.782 (1.8); 1.727 (0.5); 1.560 (1.5); 1.545 (3.0); 1.533 (2.7); 1.515 (1.1); 0.105 (0.4); 0.033 (3.1)

    Example XVII-7

    [0550] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.713 (1.2); 7.615 (1.3); 7.300 (1.2); 5.082 (5.5); 2.080 (0.4); 2.074 (0.8); 1.341 (7.2); 1.334 (16.0); 1.317 (0.5); 1.314 (0.4); 1.289 (0.5); 0.035 (0.5); 0.030 (0.7)

    Example XVII-8

    [0551] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.704 (1.9); 7.647 (1.8); 5.411 (5.6); 1.821 (16.0)

    Example XVII-9

    [0552] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.739 (8.8); 7.710 (9.5); 7.691 (0.5); 7.686 (0.4); 7.679 (0.5); 7.674 (0.4); 7.652 (0.3); 7.550 (0.9); 7.546 (0.9); 7.512 (0.3); 7.503 (1.3); 7.499 (1.0); 7.488 (0.4); 7.482 (0.4); 7.478 (0.4); 7.300 (2.7); 5.424 (0.5); 5.422 (0.4); 5.390 (0.4); 5.323 (1.4); 5.308 (0.5); 5.251 (0.6); 5.249 (0.6); 4.989 (16.0); 4.669 (6.5); 4.655 (0.5); 4.637 (12.1); 4.604 (7.1); 3.755 (0.8); 3.740 (1.0); 3.724 (0.8); 3.063 (4.1); 3.050 (0.5); 3.031 (7.3); 2.998 (3.9); 2.483 (0.5); 2.469 (0.6); 2.454 (0.5); 2.060 (0.8); 1.275 (0.5); 0.016 (2.2)

    Example XVII-10

    [0553] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.612 (2.6); 7.466 (0.6); 7.259 (116.3); 7.180 (3.6); 7.047 (0.7); 5.288 (16.0); 4.868 (0.8); 1.808 (2.1); 1.797 (6.5); 1.790 (6.9); 1.781 (2.9); 1.747 (0.4); 1.552 (48.1); 1.536 (13.2); 1.525 (11.4); 1.518 (9.8); 1.508 (4.2); 1.476 (0.9); 1.436 (0.5); 1.255 (4.5); 1.186 (0.4); 1.178 (0.5); 1.170 (0.4); 1.161 (0.3); 1.140 (0.5); 1.035 (0.4); 0.894 (0.4); 0.880 (0.7); 0.866 (0.5); 0.856 (0.4); 0.837 (0.4); 0.116 (0.4); 0.069 (1.0); 0.000 (93.5); 0.120 (0.5)

    Example XVII-11

    [0554] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =7.962 (3.7); 7.891 (4.0); 5.646 (5.5); 5.641 (5.5); 3.314 (4.0); 2.513 (8.3); 2.509 (10.9); 2.505 (8.2); 1.579 (16.0); 1.524 (16.0)

    Example XVII-13

    [0555] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.724 (1.2); 7.609 (1.0); 7.299 (1.0); 4.882 (3.1); 2.480 (3.0); 2.078 (0.8); 1.292 (0.5); 1.124 (16.0); 0.033 (1.0)

    Example XVII-14

    [0556] .sup.1H-NMR (400.1 MHz, d.sub.6-DMSO): =7.918 (3.0); 7.860 (3.2); 7.858 (3.0); 5.381 (8.2); 3.331 (14.0); 2.867 (0.4); 2.850 (1.1); 2.833 (1.4); 2.816 (1.1); 2.798 (0.4); 2.516 (2.1); 2.512 (3.9); 2.507 (5.1); 2.503 (3.7); 2.499 (1.8); 1.129 (16.0); 1.112 (15.7)

    Example XVII-15

    [0557] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =7.945 (5.5); 7.943 (5.5); 7.876 (6.1); 7.873 (5.4); 5.359 (16.0); 3.345 (1.2); 3.171 (0.5); 3.147 (1.1); 3.142 (1.1); 3.119 (2.2); 3.095 (1.3); 3.090 (1.2); 3.066 (0.6); 2.533 (1.1); 2.527 (2.2); 2.521 (3.1); 2.515 (2.2); 2.509 (1.0); 2.106 (9.6); 2.099 (0.5); 2.094 (2.3); 1.930 (0.4); 1.917 (1.0); 1.906 (0.6); 1.899 (1.0); 1.888 (1.5); 1.877 (1.5); 1.871 (1.6); 1.856 (1.3); 1.849 (1.4); 1.844 (1.3); 1.826 (0.7); 1.809 (0.5); 1.794 (0.6); 1.784 (1.8); 1.768 (1.1); 1.760 (2.1); 1.742 (1.2); 1.735 (1.3); 1.717 (1.1); 1.700 (0.5); 1.693 (0.6); 1.659 (0.4); 1.646 (1.0); 1.626 (4.9); 1.614 (4.4); 1.601 (6.3); 1.590 (3.5); 1.579 (2.1); 1.561 (0.6); 0.020 (3.3)

    Example XVII-16

    [0558] .sup.1H-NMR (499.9 MHz, CDCl.sub.3): =7.709 (10.1); 7.708 (10.5); 7.599 (9.6); 7.263 (8.7); 5.299 (0.4); 5.260 (15.5); 5.256 (16.0); 2.177 (3.0); 2.165 (6.5); 2.154 (3.9); 2.150 (4.1); 2.135 (0.5); 2.122 (3.3); 2.118 (2.9); 2.107 (6.3); 2.099 (2.8); 2.095 (3.9); 1.968 (0.4); 1.959 (0.7); 1.950 (1.2); 1.943 (2.0); 1.937 (2.7); 1.934 (2.5); 1.926 (3.3); 1.921 (2.4); 1.918 (2.5); 1.912 (2.8); 1.902 (1.1); 1.891 (1.6); 1.879 (1.4); 1.874 (1.3); 1.860 (3.2); 1.847 (3.7); 1.838 (2.4); 1.832 (1.8); 1.813 (0.5); 1.607 (2.8); 0.006 (0.4); 0.000 (9.5); 0.007 (0.6)

    Example XVII-17

    [0559] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.716 (4.8); 7.631 (4.3); 7.298 (1.8); 5.326 (0.7); 4.875 (16.0); 3.462 (1.1); 3.434 (1.7); 3.406 (1.2); 3.379 (0.4); 3.376 (0.3); 2.458 (0.4); 2.430 (0.9); 2.426 (0.9); 2.421 (1.0); 2.416 (0.7); 2.395 (1.7); 2.389 (2.1); 2.361 (1.9); 2.360 (1.8); 2.339 (1.1); 2.332 (1.2); 2.325 (1.0); 2.310 (1.4); 2.303 (1.2); 2.296 (1.8); 2.288 (1.0); 2.281 (1.2); 2.275 (1.0); 2.267 (1.5); 2.261 (0.9); 2.247 (0.5); 2.240 (0.4); 2.233 (0.3); 2.231 (0.3); 2.227 (0.4); 2.173 (0.4); 2.147 (0.6); 2.142 (0.5); 2.136 (0.5); 2.116 (1.0); 2.109 (1.1); 2.106 (0.9); 2.088 (0.4); 2.079 (1.8); 2.051 (0.7); 2.022 (0.5); 2.012 (0.5); 2.009 (0.5); 1.997 (0.6); 1.994 (0.7); 1.985 (0.3); 1.980 (0.9); 1.977 (0.9); 1.971 (0.4); 1.964 (0.7); 1.961 (0.6); 1.957 (0.5); 1.944 (0.6); 1.940 (0.5); 1.927 (0.4); 1.790 (0.8); 0.024 (1.9)

    Example XVII-18

    [0560] .sup.1H-NMR (300.2 MHz, d.sub.6-DMSO): =8.103 (0.9); 8.099 (0.9); 8.040 (5.5); 8.038 (5.5); 7.952 (0.7); 7.926 (5.9); 7.923 (5.5); 7.876 (0.8); 7.873 (0.8); 7.854 (0.6); 7.819 (0.5); 5.710 (16.0); 5.572 (2.5); 4.238 (0.7); 4.183 (1.1); 3.499 (4.5); 2.972 (1.3); 2.962 (0.9); 2.954 (1.5); 2.948 (1.0); 2.943 (2.0); 2.933 (1.7); 2.926 (2.8); 2.915 (1.5); 2.908 (2.2); 2.897 (2.0); 2.891 (1.1); 2.885 (1.0); 2.879 (1.6); 2.607 (1.2); 2.596 (0.5); 2.582 (1.7); 2.575 (2.4); 2.562 (1.6); 2.549 (2.1); 2.533 (6.0); 2.527 (11.9); 2.521 (15.1); 2.515 (11.4); 2.509 (5.8); 2.360 (0.4); 2.334 (0.3); 2.237 (0.4); 2.219 (0.6); 2.202 (0.9); 2.186 (1.2); 2.183 (1.0); 2.166 (1.1); 2.150 (1.4); 2.134 (0.9); 2.117 (0.6); 2.109 (0.4); 2.099 (0.4); 1.911 (0.4); 1.903 (0.4); 1.866 (0.5); 1.840 (0.9); 1.828 (0.5); 1.811 (1.5); 1.803 (0.9); 1.799 (0.9); 1.786 (1.0); 1.781 (0.9); 1.774 (1.3); 1.756 (0.6); 1.748 (0.7); 0.031 (0.7); 0.020 (21.4); 0.009 (0.9)

    Example XVII-19

    [0561] .sup.1H-NMR (300.2 MHz, CDCl.sub.3): =7.705 (5.6); 7.703 (5.5); 7.621 (5.1); 7.300 (1.3); 4.919 (16.0); 2.601 (3.8); 2.577 (6.6); 2.552 (4.3); 1.727 (0.9); 1.703 (2.7); 1.695 (0.9); 1.678 (3.4); 1.671 (1.4); 1.652 (2.5); 1.627 (1.2); 1.453 (0.6); 1.429 (1.9); 1.403 (2.7); 1.384 (1.3); 1.378 (2.9); 1.361 (0.6); 1.354 (1.8); 1.330 (0.6); 0.977 (6.9); 0.953 (13.5); 0.929 (5.4); 0.017 (1.3)

    Use Examples

    Example A: In Vivo Preventive Test on Alternaria brassicae (Leaf Spot on Radish)

    [0562] Solvent: 5% by volume of Dimethyl sulfoxide [0563] 10% by volume of Acetone [0564] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0565] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0566] The young plants of radish are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0567] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Alternaria brassicae spores. The contaminated radish plants are incubated for 6 days at 20 C. and at 100% relative humidity.

    [0568] The test is evaluated 6 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    [0569] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-04; I-13; I-18; I-53; I-66; I-69; I-70; I-112; I-155.

    [0570] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-01; I-03; I-19; I-20; I-22; I-23; I-40; I-54; I-55; I-99.

    [0571] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-02; I-15; I-16; I-17; I-27; I-32; I-33; I-34; I-114.

    Example B: In Vivo Preventive Test on Botrytis Cinerea (Grey Mould)

    [0572] Solvent: 5% by volume of Dimethyl sulfoxide [0573] 10% by volume of Acetone [0574] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0575] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0576] The young plants of gherkin are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0577] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Botrytis cinerea spores. The contaminated gherkin plants are incubated for 4 to 5 days at 17 C. and at 90% relative humidity.

    [0578] The test is evaluated 4 to 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    [0579] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-15; I-66; I-72; I-98; I-131; I-137; I-149.

    [0580] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-13; I-17; I-42; I-45; I-69; I-75; I-125; I-138; I-142; I-154.

    [0581] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-02; I-04; I-05; I-06; I-08; I-14; I-16; I-18; I-21; I-25; I-27; I-29; I-30; I-32; I-33; I-34; I-36; I-38; I-39; I-40; I-43; I-44; I-54; I-55; I-59; I-65; I-71; I-73; I-76; I-77; I-79; I-82; I-99; I-107; I-108; I-110; I-112; I-114; I-118; I-124; I-126; I-128; I-130; I-133; I-139; I-144; I-146; I-147; I-155; I-157; I-158; I-164; I-167.

    Example C: In Vivo Preventive Test on Puccinia recondita (Brown Rust on Wheat)

    [0582] Solvent: 5% by volume of Dimethyl sulfoxide [0583] 10% by volume of Acetone [0584] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0585] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0586] The young plants of wheat are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0587] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Puccinia recondita spores. The contaminated wheat plants are incubated for 24 hours at 20 C. and at 100% relative humidity and then for 10 days at 20 C. and at 70-80% relative humidity.

    [0588] The test is evaluated 11 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    [0589] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-61; I-68; I-75; I-105; I-132; I-169.

    [0590] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-02; I-03; I-05; I-07; I-10; I-11; I-12; I-13; I-14; I-15; I-16; I-17; I-20; I-21; I-24; I-25; I-28; I-33; I-37; I-38; I-40; I-44; I-47; I-48; I-50; I-52; I-54; I-56; I-58; I-59; I-67; I-69; I-70; I-72; I-73; I-77; I-80; I-89; I-90; I-92; I-106; I-107; I-110; I-113; I-121; I-122; I-123; I-127; I-137; I-142; I-151; I-155; I-158; I-164; I-167.

    [0591] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-01; I-04; I-06; I-08; I-18; I-19; I-22; I-23; I-26; I-27; I-29; I-30; I-31; I-32; I-34; I-36; I-39; I-41; I-42; I-43; I-45; I-46; I-49; I-51; I-53; I-55; I-57; I-62; I-64; I-65; I-66; I-71; I-76; I-79; I-81; I-82; I-84; I-85; I-88; I-91; I-95; I-96; I-97; I-98; I-99; I-101; I-103; I-104; I-108; I-109; I-111; I-112; I-114; I-115; I-117; I-118; I-120; I-124; I-125; I-126; I-128; I-130; I-131; I-133; I-136; I-138; I-139; I-141; I-143; I-144; I-146; I-147; I-148; I-149; I-152; I-153; I-154; I-156; I-157; I-165; I-166.

    Example D: In Vivo Preventive Test on Pyrenophora Teres (Net Blotch on Barley)

    [0592] Solvent: 5% by volume of Dimethyl sulfoxide [0593] 10% by volume of Acetone [0594] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0595] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0596] The young plants of barley are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0597] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Pyrenophora teres spores. The contaminated barley plants are incubated for 48 hours at 20 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

    [0598] The test is evaluated 14 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    [0599] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-07; I-40; I-42; I-48; I-53; I-56; I-118; I-120; I-121; I-130; I-139; I-143; I-151; I-152; I-155.

    [0600] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-08; I-11; I-13; I-14; I-19; I-22; I-23; I-25; I-29; I-32; I-33; I-38; I-45; I-50; I-54; I-55; I-69; I-72; I-73; I-75; I-77; I-80; I-82; I-84; I-85; I-89; I-95; I-97; I-103; I-112; I-131; I-142; I-148; I-153; I-156; I-164; I-166; I-167.

    [0601] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-01; I-02; I-04; I-06; I-12; I-15; I-16; I-17; I-18; I-27; I-30; I-34; I-36; I-39; I-43; I-44; I-49; I-51; I-62; I-65; I-66; I-71; I-76; I-79; I-88; I-98; I-99; I-101; I-107; I-108; I-109; I-110; I-114; I-124; I-126; I-133; I-144; I-146; I-147; I-157; I-158.

    Example E: In Vivo Preventive Test on Septoria tritici (Leaf Spot on Wheat)

    [0602] Solvent: 5% by volume of Dimethyl sulfoxide [0603] 10% by volume of Acetone [0604] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0605] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0606] The young plants of wheat are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0607] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Septoria tritici spores. The contaminated wheat plants are incubated for 72 hours at 18 C. and at 100% relative humidity and then for 21 days at 20 C. and at 90% relative humidity.

    [0608] The test is evaluated 24 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    [0609] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-09; I-21; I-90; I-105; I-118; I-120; I-134; I-142; I-166; I-169.

    [0610] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-05; I-20; I-28; I-58; I-65; I-69; I-73; I-78; I-87; I-110; I-149.

    [0611] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-01; I-02; I-03; I-04; I-06; I-07; I-08; I-11; I-12; I-13; I-14; I-15; I-16; I-17; I-18; I-19; I-22; I-23; I-24; I-25; I-26; I-27; I-29; I-30; I-31; I-32; I-33; I-34; I-35; I-36; I-37; I-38; I-39; I-40; I-41; I-42; I-43; I-44; I-45; I-48; I-49; I-50; I-51; I-52; I-53; I-54; I-55; I-56; I-57; I-59; I-61; I-62; I-64; I-66; I-70; I-71; I-72; I-74; I-75; I-76; I-77; I-79; I-80; I-81; I-82; I-84; I-85; I-88; I-91; I-92; I-95; I-96; I-97; I-98; I-99; I-101; I-103; I-104; I-106; I-107; I-108; I-109; I-111; I-112; I-113; I-115; I-116; I-117; I-121; I-122; I-123; I-124; I-125; I-126; I-127; I-128; I-130; I-131; I-132; I-133; I-136; I-137; I-138; I-139; I-141; I-143; I-144; I-146; I-147; I-148; I-151; I-152; I-153; I-154; I-155; I-156; I-157; I-158; I-164; I-165.

    Example F: In Vivo Preventive Test on Sphaerotheca Fuliginea (Powdery Mildew on Cucurbits)

    [0612] Solvent: 5% by volume of Dimethyl sulfoxide [0613] 10% by volume of Acetone [0614] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0615] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0616] The young plants of gherkin are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0617] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Sphaerotheca fuliginea spores. The contaminated gherkin plants are incubated for 72 hours at 18 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

    [0618] The test is evaluated 15 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    [0619] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-78.

    [0620] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-01; I-02; I-03; I-04; I-05; I-06; I-07; I-08; I-09; I-11; I-12; I-13; I-14; I-15; I-16; I-17; I-18; I-19; I-20; I-21; I-22; I-23; I-24; I-25; I-26; I-27; I-28; I-29; I-30; I-31; I-32; I-33; I-34; I-36; I-38; I-39; I-40; I-41; I-42; I-43; I-44; I-45; I-46; I-47; I-48; I-49; I-50; I-51; I-52; I-53; I-54; I-55; I-56; I-57; I-58; I-59; I-61; I-62; I-64; I-65; I-66; I-67; I-69; I-70; I-71; I-72; I-73; I-74; I-75; I-76; I-77; I-79; I-80; I-81; I-82; I-84; I-85; I-87; I-88; I-89; I-90; I-91; I-92; I-95; I-96; I-97; I-98; I-99; I-101; I-103; I-104; I-105; I-106; I-107; I-108; I-109; I-110; I-111; I-112; I-113; I-114; I-115; I-116; I-117; I-118; I-120; I-121; I-122; I-123; I-124; I-125; I-126; I-127; I-128; I-130; I-131; I-132; I-133; I-134; I-136; I-137; I-138; I-139; I-141; I-142; I-143; I-144; I-146; I-147; I-149; I-151; I-152; I-153; I-154; I-155; I-156; I-157; I-158; I-164; I-165; I-166; I-167; I-169.

    Example G: In Vivo Preventive Test on Uromyces appendiculatus (Bean Rust)

    [0621] Solvent: 5% by volume of Dimethyl sulfoxide [0622] 10% by volume of Acetone [0623] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0624] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0625] The young plants of bean are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0626] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Uromyces appendiculatus spores. The contaminated bean plants are incubated for 24 hours at 20 C. and at 100% relative humidity and then for 10 days at 20 C. and at 70-80% relative humidity.

    [0627] The test is evaluated 11 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    [0628] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-21; I-28; I-134; I-169.

    [0629] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-51; I-107; I-114; I-123.

    [0630] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-01; I-02; I-03; I-04; I-05; I-06; I-07; I-08; I-09; I-10; I-11; I-12; I-14; I-15; I-16; I-17; I-18; I-20; I-22; I-23; I-24; I-25; I-26; I-27; I-29; I-30; I-31; I-32; I-33; I-34; I-36; I-38; I-39; I-40; I-41; I-42; I-43; I-44; I-45; I-46; I-47; I-48; I-49; I-50; I-52; I-53; I-54; I-55; I-56; I-57; I-58; I-59; I-61; I-62; I-64; I-65; I-66; I-67; I-68; I-69; I-70; I-71; I-72; I-74; I-75; I-77; I-79; I-80; I-81; I-82; I-84; I-85; I-88; I-89; I-90; I-91; I-92; I-95; I-96; I-97; I-98; I-99; I-101; I-103; I-104; I-106; I-109; I-110; I-111; I-112; I-113; I-115; I-117; I-118; I-120; I-121; I-122; I-124; I-125; I-126; I-127; I-128; I-130; I-131; I-132; I-133; I-136; I-137; I-138; I-139; I-141; I-142; I-144; I-146; I-147; I-148; I-149; I-151; I-152; I-153; I-154; I-155; I-156; I-157; I-158; I-164; I-165; I-166; I-167.

    Example H: In Vivo Preventive Test on Alternaria Test (Tomatoes)

    [0631] Solvent: 24.5 parts by weight of acetone [0632] 24.5 parts by weight of dimethylacetamide [0633] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0634] To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0635] To test for preventive activity, young plants are sprayed with the preparation of active compound at the stated rate of application. After the spray coating has dried on, the plants are inoculated with an aqueous spore suspension of Alternaria solani. The plants are then placed in an incubation cabinet at approximately 20 C. and a relative atmospheric humidity of 100%.

    [0636] The test is evaluated 3 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control while an efficacy of 100% means that no disease is observed.

    [0637] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 100 ppm of active ingredient: I-05; I-42; I-50; I-96.

    [0638] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 100 ppm of active ingredient: I-26; I-43; I-97; I-103; I-133; I-157.

    [0639] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 100 ppm of active ingredient: I-04; I-06; I-08; I-16; I-17; I-18; I-27; I-29; I-30; I-32; I-33; I-34; I-36; I-38; I-39; I-40; I-44; I-65; I-69; I-95; I-98; I-99; I-101; I-107; I-112; I-114; I-125; I-126; I-146; I-147; I-153; I-155; I-158.

    Example I: In Vivo Preventive Test on Phakopsora Test (Soybeans)

    [0640] Solvent: 24.5 parts by weight of acetone [0641] 24.5 parts by weight of dimethylacetamide [0642] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0643] To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0644] To test for preventive activity, young plants are sprayed with the preparation of active compound at the stated rate of application. After the spray coating has dried on, the plants are inoculated with an aqueous spore suspension of the causal agent of soybean rust (Phakopsorapachyrhizi) and stay for 24 h without light in an incubation cabinet at approximately 24 C. and a relative atmospheric humidity of 95%.

    [0645] The plants remain in the incubation cabinet at approximately 24 C. and a relative atmospheric humidity of approximately 80% and a day/night interval of 12 h.

    [0646] The test is evaluated 7 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

    [0647] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 100 ppm of active ingredient: I-26.

    [0648] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 100 ppm of active ingredient: I-50; I-96; I-107; I-133.

    [0649] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 100 ppm of active ingredient: I-04; I-05; I-06; I-08; I-16; I-17; I-18; I-23; I-27; I-29; I-30; I-32; I-33; I-34; I-36; I-38; I-39; I-40; I-42; I-43; I-44; I-65; I-69; I-95; I-97; I-98; I-99; I-101; I-103; I-112; I-114; I-125; I-126; I-138; I-146; I-147; I-153; I-155; I-157; I-158.

    Example J: In Vivo Preventive Test on Venturia Test (Apples)

    [0650] Solvent: 24.5 parts by weight of acetone [0651] 24.5 parts by weight of dimethylacetamide [0652] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0653] To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0654] To test for preventive activity, young plants are sprayed with the preparation of active compound at the stated rate of application. After the spray coating has dried on, the plants are inoculated with an aqueous conidia suspension of the causal agent of apple scab (Venturia inaequalis) and then remain for 1 day in an incubation cabinet at approximately 20 C. and a relative atmospheric humidity of 100%.

    [0655] The plants are then placed in a greenhouse at approximately 21 C. and a relative atmospheric humidity of approximately 90%.

    [0656] The test is evaluated 10 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

    [0657] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 100 ppm of active ingredient: I-133; I-138.

    [0658] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 100 ppm of active ingredient: I-06; I-40; I-42; I-50; I-65; I-95; I-96; I-97; I-99; I-101; I-103; I-107; I-112; I-114; I-153.

    [0659] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 100 ppm of active ingredient: I-04; I-08; I-16; I-17; I-18; I-26; I-27; I-29; I-30; I-32; I-33; I-34; I-36; I-38; I-44; I-69; I-98; I-125; I-146; I-147; I-155; I-157.

    Example K: In Vivo Preventive Blumeria Test (Barley)

    [0660] Solvent: 49 parts by weight of N,N-dimethylacetamide [0661] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0662] To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0663] To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application.

    [0664] After the spray coating has been dried, the plants are dusted with spores of Blumeria graminis fsp. hordei.

    [0665] The plants are placed in the greenhouse at a temperature of approximately 18 C. and a relative atmospheric humidity of approximately 80% to promote the development of mildew pustules.

    [0666] The test is evaluated 7 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

    [0667] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-17; I-25.

    [0668] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-43.

    [0669] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-01; I-02; I-04; I-06; I-08; I-16; I-18; I-22; I-26; I-27; I-29; I-30; I-32; I-33; I-34; I-36; I-38; I-39; I-40; I-41; I-42; I-44; I-49; I-50; I-62; I-64; I-65; I-72; I-75; I-80; I-84; I-88; I-92; I-95; I-96; I-97; I-98; I-99; I-101; I-103; I-109; I-112; I-114; I-125; I-126; I-133; I-136; I-138; I-144; I-146; I-147; I-152; I-154; I-156; I-157; 164; I-165.

    Example L: In Vivo Preventive Fusarium culmorum Test (Wheat)

    [0670] Solvent: 49 parts by weight of N,N-dimethylacetamide [0671] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0672] To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0673] To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application. After the spray coating has been dried, the plants are slightly injured by using a sandblast and afterwards they are sprayed with a conidia suspension of Fusarium culmorum.

    [0674] The plants are placed in the greenhouse under a translucent incubation cabinet at a temperature of approximately 22 C. and a relative atmospheric humidity of approximately 100%.

    [0675] The test is evaluated 5 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

    [0676] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-02.

    [0677] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-18; I-29; I-36; I-38.

    [0678] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-06; I-16; I-26; I-34; I-39; I-65; I-95; I-97; I-133; I-157.

    Example M: In Vivo Preventive Fusarium graminearum Test (Barley)

    [0679] Solvent: 49 parts by weight of N,N-dimethylacetamide [0680] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0681] To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0682] To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application.

    [0683] After the spray coating has been dried, the plants are slightly injured by using a sandblast and afterwards they are sprayed with a conidia suspension of Fusarium graminearum.

    [0684] The plants are placed in the greenhouse under a translucent incubation cabinet at a temperature of approximately 25 C. and a relative atmospheric humidity of approximately 100%.

    [0685] The test is evaluated 5 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

    [0686] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-04; I-08; I-32; I-44; I-49; I-72; I-112; I-114; I-152.

    [0687] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-02; I-16; I-42; I-64; I-156.

    [0688] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-06; I-18; I-29; I-34; I-39; I-41; I-65; I-88; I-95; I-96; I-97; I-98; I-99; I-103; I-109; I-125; I-126; I-133; I-138; I-144; I-146; I-147; I-154; I-157.

    Example N: In Vivo Preventive Leptosphaeria nodorum Test (Wheat)

    [0689] Solvent: 49 parts by weight of N,N-dimethylacetamide [0690] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0691] To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0692] To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application.

    [0693] After the spray coating has been dried, the plants are sprayed with a spore suspension of Leptosphaeria nodorum. The plants remain for 48 hours in an incubation cabinet at approximately 20 C. and a relative atmospheric humidity of approximately 100%.

    [0694] The plants are placed in the greenhouse at a temperature of approximately 25 C. and a relative atmospheric humidity of approximately 80%.

    [0695] The test is evaluated 8 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

    [0696] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-26; I-39; I-41; I-152.

    [0697] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-11; I-32; I-36; I-38; I-44; I-49; I-65; I-95; I-125; I-157.

    [0698] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-02; I-04; I-06; I-08; I-16; I-18; I-27; I-29; I-30; I-33; I-34; I-42; I-72; I-99; 133; I-146; I-147; I-154.

    Example O: In Vivo Preventive Fusarium nivale (Var. Majus) Test (Wheat)

    [0699] Solvent: 49 parts by weight of N,N-dimethylacetamide [0700] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0701] To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0702] To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application.

    [0703] After the spray coating has been dried, the plants are slightly injured by using a sandblast and afterwards they are sprayed with a conidia suspension of Fusarium nivale (var. majus).

    [0704] The plants are placed in the greenhouse under a translucent incubation cabinet at a temperature of approximately 10 C. and a relative atmospheric humidity of approximately 100%.

    [0705] The test is evaluated 5 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

    [0706] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-01; I-39.

    [0707] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-11; I-32; I-41; I-42; I-49; I-88; I-109; I-157; I-164.

    [0708] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-02; I-04; I-06; I-08; I-16; I-18; I-26; I-29; I-34; I-36; I-38; I-50; I-65; I-72; I-95; I-97; I-99; I-125; I-133; I-146; I-147; I-152; I-154.

    Example P: In Vivo Preventive Pyricularia Oryzae Test (Rice)

    [0709] Solvent: 49 parts by weight of N,N-dimethylacetamide [0710] Emulsifier: 1 part by weight of alkylaryl polyglycol ether

    [0711] To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

    [0712] To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application.

    [0713] After the spray coating has been dried, the plants are sprayed with a spore suspension of Pyricularia oryzae. The plants remain for 48 hours in an incubation cabinet at approximately 25 C. and a relative atmospheric humidity of approximately 100%.

    [0714] The plants are placed in the greenhouse under a translucent incubations cabinet at a temperature of approximately 25 C. and a relative atmospheric humidity of approximately 100%.

    [0715] The test is evaluated 8 days after the inoculation. 0% means an efficacy which corresponds to that of the control, while an efficacy of 100% means that no disease is observed.

    [0716] In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-02; I-08; I-25; I-39; I-40; I-44; I-50; I-84; I-95; I-97; I-112; I-114; I-144; I-146; I-154; I-164.

    [0717] In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-11; I-22; I-26; I-42; I-49; I-92; I-99; I-125; I-138; I-147.

    [0718] In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-04; I-06; I-16; I-17; I-18; I-27; I-30; I-36; I-38; I-65; I-72; I-98; I-126; I-133; I-157; I-165.

    Examples Q

    [0719] The following examples Q1 to Q4 provide comparative data of the efficacy of 5-substituted imidazolylmethyl compounds according to the invention vs. an unsubstituted imidazolylmethyl compound against several pathogens. The data clearly demonstrate the superior properties of compounds according to the invention.

    Example Q1: In Vivo Preventive Test on Botrytis cinerea (Grev Mould)

    [0720] Solvent: 5% by volume of Dimethyl sulfoxide [0721] 10% by volume of Acetone [0722] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0723] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0724] The young plants of gherkin are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0725] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Botrytis cinerea spores. The contaminated gherkin plants are incubated for 4 to 5 days at 17 C. and at 90% relative humidity.

    [0726] The test is evaluated 4 to 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    TABLE-US-00003 TABLE results Rate of application of active compound in Efficacy Active compound ppm in % Comparison compound [00043]embedded image 500 100 100 70 According to the invention: I-27 [00044]embedded image 500 100 100 99 I-29 [00045]embedded image 500 100 99 86 I-30 [00046]embedded image 500 100 100 100

    Example Q2: In Vivo Preventive Test on Pyrenophora Teres (Net Blotch on Barley)

    [0727] Solvent: 5% by volume of Dimethyl sulfoxide [0728] 10% by volume of Acetone [0729] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0730] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0731] The young plants of barley are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0732] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Pyrenophora teres spores. The contaminated barley plants are incubated for 48 hours at 20 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

    [0733] The test is evaluated 14 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    TABLE-US-00004 TABLE results Rate of application of active compound in Efficacy Active compound ppm in % Comparison compound [00047]embedded image 500 100 0 0 According to the invention: I-27 [00048]embedded image 500 100 98 94 I-29 [00049]embedded image 500 100 89 83 I-30 [00050]embedded image 500 100 94 91

    Example Q3: In Vivo Preventive Test on Septoria tritici (Leaf Spot on Wheat)

    [0734] Solvent: 5% by volume of Dimethyl sulfoxide [0735] 10% by volume of Acetone [0736] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0737] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0738] The young plants of wheat are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0739] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Septoria tritici spores. The contaminated wheat plants are incubated for 72 hours at 18 C. and at 100% relative humidity and then for 21 days at 20 C. and at 90% relative humidity.

    [0740] The test is evaluated 24 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    TABLE-US-00005 TABLE results Rate of application of active compound in Efficacy Active compound ppm in % Comparison compound [00051]embedded image 500 100 100 0 According to the invention: I-27 [00052]embedded image 500 100 94 81 I-29 [00053]embedded image 500 100 100 100 I-30 [00054]embedded image 500 100 98 94

    Example Q4: In Vitro Test for the Calculation of the ED50-Value with Microorganisms

    [0741] Solvent: Dimethyl sulfoxide [0742] Culture medium: 14.6 g anhydrous D-glucose (VWR), 7.1 g Mycological Peptone (Oxoid), 1.4 g granulated Yeast Extract (Merck), QSP liter [0743] Inoculum: Spore suspension

    [0744] Fungicides were solubilized in DMSO and the solution used to prepare the required range of concentrations. The final concentration of DMSO used in the assay was 1%.

    [0745] A spore suspension was prepared and diluted to the desired spore density.

    [0746] Fungicides were evaluated for their ability to inhibit spore germination and mycelium growth in liquid culture assay. The compounds were added in the desired concentration to the culture medium with spores. After 4 to 7 days incubation, fungi-toxicity of compounds was determined by spectrometric measurement of mycelium growth. Inhibition of fungal growth was determined by comparing the absorbance values in wells containing the fungicides with the absorbance in control wells without fungicides.

    TABLE-US-00006 TABLE results Leptosphaeria Septoria tritici Fusarium Botrytis nodorum ED50 culmorum cinerea ED50 ED50 value in value in ED50 value Active compound value in ppm ppm ppm in ppm Comparison compound [00055]embedded image 0.53 0.04 0.02 0.04 According to the invention: I-27 [00056]embedded image 0.02 <0.006 <0.006 <0.006 I-29 [00057]embedded image 0.26 0.02 <0.006 0.01 I-30 [00058]embedded image 0.08 0.01 <0.006 0.01

    Examples R

    [0747] The following examples R1 to R7 provide comparative data of the efficacy of 5-substituted imidazolylmethyl compounds according to the invention vs. substituted imidazolylmethyl derivatives bearing the substituent in another position against several pathogens. The data clearly demonstrate the superior properties of compounds according to the invention.

    Example R1: In Vivo Preventive Test on Alternaria brassicae (Leaf Spot on Radish)

    [0748] Solvent: 5% by volume of Dimethyl sulfoxide [0749] 10% by volume of Acetone [0750] Emulsifier: 1 l of Tween 80 per mg of active ingredient

    [0751] The active ingredients are made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone/Tween 80 and then diluted in water to the desired concentration.

    [0752] The young plants of radish are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

    [0753] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Alternaria brassicae spores. The contaminated radish plants are incubated for 6 days at 20 C. and at 100% relative humidity.

    [0754] The test is evaluated 6 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    Results:

    [0755]

    TABLE-US-00007 Rate of application of Efficacy Active compound active compound in ppm in % Comparison compound [00059]embedded image 500 100 40 0 According to the invention: I-04 [00060]embedded image 500 100 70 20 Comparison compound [00061]embedded image 500 100 0 0 According to the invention: I-03 [00062]embedded image 500 100 83 0 Comparison compound [00063]embedded image 500 100 0 0 Comparison compound [00064]embedded image 500 100 0 0 According to the invention: I-32 [00065]embedded image 500 100 92 50 Comparison compound [00066]embedded image 500 100 0 0 According to the invention: I-27 [00067]embedded image 500 100 92 50 Comparison compound [00068]embedded image 500 100 0 0 According to the invention: I-34 [00069]embedded image 500 100 92 58

    Example R2: In Vivo Preventive Test on Botrytis cinerea (Grey Mould)

    [0756] The tested active ingredients are prepared by homogenization in a mixture of acetone/Dimethyl sulfoxide/Tween as disclosed above, and then diluted with water to obtain the desired active material concentration.

    [0757] The young plants of gherkin are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of acetone/Dimethyl sulfoxide/Tween.

    [0758] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Botrytis cinerea spores. The contaminated gherkin plants are incubated for 4 to 5 days at 17 C. and at 90% relative humidity.

    [0759] The test is evaluated 4 to 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    Results:

    [0760]

    TABLE-US-00008 Rate of application of Efficacy Active compound active compound in ppm in % Comparison compound [00070]embedded image 500 100 0 5 According to the invention: I-04 [00071]embedded image 500 100 100 90 Comparison compound [00072]embedded image 500 100 0 0 According to the invention: I-06 [00073]embedded image 500 100 97 80 Comparison compound [00074]embedded image 500 100 0 0 According to the invention: I-36 [00075]embedded image 500 100 100 100 Comparison compound [00076]embedded image 500 100 0 0 Comparison compound [00077]embedded image 500 100 0 0 According to the invention: I-32 [00078]embedded image 500 100 100 99 Comparison compound [00079]embedded image 500 100 19 0 According to the invention: I-30 [00080]embedded image 500 100 100 100 Comparison compound [00081]embedded image 500 100 0 0 According to the invention: I-29 [00082]embedded image 500 100 99 86 Comparison compound [00083]embedded image 500 100 0 0 According to the invention: I-27 [00084]embedded image 500 100 100 99 Comparison compound [00085]embedded image 500 100 0 0 According to the invention: I-34 [00086]embedded image 500 100 100 94

    Example R3: In Vivo Preventive Test on Puccinia recondita (Brown Rust on Wheat)

    [0761] The tested active ingredients are prepared by homogenization in a mixture of acetone/Dimethyl sulfoxide/Tween as disclosed above, and then diluted with water to obtain the desired active material concentration.

    [0762] The young plants of wheat are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of acetone/Dimethyl sulfoxide/Tween.

    [0763] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Puccinia recondita spores. The contaminated wheat plants are incubated for 24 hours at 20 C. and at 100% relative humidity and then for 10 days at 20 C. and at 70-80% relative humidity.

    [0764] The test is evaluated 11 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    Results:

    [0765]

    TABLE-US-00009 Rate of application of Efficacy Active compound active compound in ppm in % Comparison compound [00087]embedded image 500 100 81 75 According to the invention: I-04 [00088]embedded image 500 100 94 88 Comparison compound [00089]embedded image 500 100 86 29 According to the invention: I-03 [00090]embedded image 500 100 86 86 Comparison compound [00091]embedded image 500 100 83 0 According to the invention: I-06 [00092]embedded image 500 100 94 89 Comparison compound [00093]embedded image 500 100 13 0 According to the invention: I-36 [00094]embedded image 500 100 94 89 Comparison compound [00095]embedded image 500 100 33 0 Comparison compound [00096]embedded image 500 100 0 0 According to the invention: I-32 [00097]embedded image 500 100 94 78 Comparison compound [00098]embedded image 500 100 94 0 According to the invention: I-30 [00099]embedded image 500 100 94 88 Comparison compound [00100]embedded image 500 100 94 81 According to the invention: I-29 [00101]embedded image 500 100 98 94 Comparison compound [00102]embedded image 500 100 67 0 According to the invention: I-27 [00103]embedded image 500 100 98 89 Comparison compound [00104]embedded image 500 100 78 11 According to the invention: I-34 [00105]embedded image 500 100 100 94

    Example R4: In Vivo Preventive Test on Pyrenophora teres (Net Blotch on Barley)

    [0766] The tested active ingredients are prepared by homogenization in a mixture of acetone/Dimethyl sulfoxide/Tween as disclosed above, and then diluted with water to obtain the desired active material concentration.

    [0767] The young plants of barley are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of acetone/Dimethyl sulfoxide/Tween.

    [0768] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Pyrenophora teres spores. The contaminated barley plants are incubated for 48 hours at 20 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

    [0769] The test is evaluated 14 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    Results:

    [0770]

    TABLE-US-00010 Rate of application of Efficacy Active compound active compound in ppm in % Comparison compound [00106]embedded image 500 100 0 0 According to the invention: I-04 [00107]embedded image 500 100 93 71 Comparison compound [00108]embedded image 500 100 0 0 According to the invention: I-06 [00109]embedded image 500 100 93 86 Comparison compound [00110]embedded image 500 100 0 0 According to the invention: I-36 [00111]embedded image 500 100 93 57 Comparison compound [00112]embedded image 500 100 0 0 Comparison compound [00113]embedded image 500 100 0 0 According to the invention: I-32 [00114]embedded image 500 100 89 78 Comparison compound [00115]embedded image 500 100 38 0 According to the invention: I-30 [00116]embedded image 500 100 94 81 Comparison compound [00117]embedded image 500 100 25 0 According to the invention: I-29 [00118]embedded image 500 100 89 83 Comparison compound [00119]embedded image 500 100 0 0 According to the invention: I-27 [00120]embedded image 500 100 98 94 Comparison compound [00121]embedded image 500 100 0 0 According to the invention: I-34 [00122]embedded image 500 100 98 83

    Example R5: In Vivo Preventive Test on Septoria tritici (Leaf Spot on Wheat)

    [0771] The tested active ingredients are prepared by homogenization in a mixture of acetone/Dimethyl sulfoxide/Tween as disclosed above, and then diluted with water to obtain the desired active material concentration.

    [0772] The young plants of wheat are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of acetone/Dimethyl sulfoxide/Tween.

    [0773] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Septoria tritici spores. The contaminated wheat plants are incubated for 72 hours at 18 C. and at 100% relative humidity and then for 21 days at 20 C. and at 90% relative humidity.

    [0774] The test is evaluated 24 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    Results:

    [0775]

    TABLE-US-00011 Rate of application of Efficacy Active compound active compound in ppm in % Comparison compound [00123]embedded image 500 100 83 75 According to the invention: I-04 [00124]embedded image 500 100 100 97 Comparison compound [00125]embedded image 500 100 33 17 According to the invention: I-03 [00126]embedded image 500 100 100 83 Comparison compound [00127]embedded image 500 100 78 44 According to the invention: I-06 [00128]embedded image 500 100 100 98 Comparison compound [00129]embedded image 500 100 63 63 According to the invention: I-36 [00130]embedded image 500 100 75 83 Comparison compound [00131]embedded image 500 100 93 0 Comparison compound [00132]embedded image 500 100 96 20 According to the invention: I-32 [00133]embedded image 500 100 100 71 Comparison compound [00134]embedded image 500 100 94 38 According to the invention: I-30 [00135]embedded image 500 100 98 94 Comparison compound [00136]embedded image 500 100 100 63 According to the invention: I-29 [00137]embedded image 500 100 100 100 Comparison compound [00138]embedded image 500 100 75 0 According to the invention: I-27 [00139]embedded image 500 100 81 94 Comparison compound [00140]embedded image 500 100 86 14 According to the invention: I-34 [00141]embedded image 500 100 100 100

    Example R6: In Vivo Preventive Test on Sphaerotheca fuliginea (Powdery Mildew on Cucurbits)

    [0776] The tested active ingredients are prepared by homogenization in a mixture of acetone/Dimethyl sulfoxide/Tween as disclosed above, and then diluted with water to obtain the desired active material concentration.

    [0777] The young plants of gherkin are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of acetone/Dimethyl sulfoxide/Tween.

    [0778] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Sphaerotheca fuliginea spores. The contaminated gherkin plants are incubated for 72 hours at 18 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

    [0779] The test is evaluated 15 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    Results:

    [0780]

    TABLE-US-00012 Rate of application of Efficacy Active compound active compound in ppm in % Comparison compound [00142]embedded image 500 100 30 20 According to the invention: I-04 [00143]embedded image 500 100 100 100 Comparison compound [00144]embedded image 500 100 30 0 According to the invention: I-03 [00145]embedded image 500 100 100 85 Comparison compound [00146]embedded image 500 100 60 0 According to the invention: I-36 [00147]embedded image 500 100 100 100 Comparison compound [00148]embedded image 500 100 98 60 Comparison compound [00149]embedded image 500 100 78 0 According to the invention: I-32 [00150]embedded image 500 100 100 100 Comparison compound [00151]embedded image 500 100 100 60 According to the invention: I-30 [00152]embedded image 500 100 100 100 Comparison compound [00153]embedded image 500 100 90 90 According to the invention: I-29 [00154]embedded image 500 100 100 100 Comparison compound [00155]embedded image 500 100 80 0 According to the invention: I-27 [00156]embedded image 500 100 100 100 Comparison compound [00157]embedded image 500 100 95 95 According to the invention: I-34 [00158]embedded image 500 100 100 100

    Example R7: In Vivo Preventive Test on Uromyces appendiculatus (Bean Rust)

    [0781] The tested active ingredients are prepared by homogenization in a mixture of acetone/Dimethyl sulfoxide/Tween as disclosed above, and then diluted with water to obtain the desired active material concentration.

    [0782] The young plants of bean are treated by spraying the active ingredient prepared as described above. Control plants are treated only with an aqueous solution of acetone/Dimethyl sulfoxide/Tween.

    [0783] After 24 hours, the plants are contaminated by spraying the leaves with an aqueous suspension of Uromyces appendiculatus spores. The contaminated bean plants are incubated for 24 hours at 20 C. and at 100% relative humidity and then for 10 days at 20 C. and at 70-80% relative humidity.

    [0784] The test is evaluated 11 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease is observed.

    Results:

    [0785]

    TABLE-US-00013 Rate of application of Efficacy Active compound active compound in ppm in % Comparison compound [00159]embedded image 500 100 47 56 According to the invention: I-04 [00160]embedded image 500 100 100 100 Comparison compound [00161]embedded image 500 100 100 0 According to the invention: I-03 [00162]embedded image 500 100 100 81 Comparison compound [00163]embedded image 500 100 50 25 According to the invention: I-06 [00164]embedded image 500 100 100 100 Comparison compound [00165]embedded image 500 100 0 0 According to the invention: I-36 [00166]embedded image 500 100 100 100 Comparison compound [00167]embedded image 500 100 0 0 Comparison compound [00168]embedded image 500 100 0 0 According to the invention: I-32 [00169]embedded image 500 100 100 81 Comparison compound [00170]embedded image 500 100 38 0 According to the invention: I-30 [00171]embedded image 500 100 100 88 Comparison compound [00172]embedded image 500 100 94 31 According to the invention: I-29 [00173]embedded image 500 100 100 100 Comparison compound [00174]embedded image 500 100 0 0 According to the invention: I-27 [00175]embedded image 500 100 100 20 Comparison compound [00176]embedded image 500 100 56 25 According to the invention: I-34 [00177]embedded image 500 100 100 100