COLLAGEN-CONTAINING WOUND DRESSING AND METHOD FOR THE PRODUCTION THEREOF

Abstract

The invention relates to a method for producing an implant, which is in particular in the form of a wound dressing. The implant consists of a sheet-like structure made of magnesium, which is embedded in a collagen non-woven fabric.

Claims

1-15. (canceled)

16. A method for producing a geometrically stable bioresorbable wound dressing membrane, the method comprising: covering a sheet-like structure made of magnesium or a magnesium alloy with a collagen-containing preparation; and drying of the collagen-containing preparation.

17. The method for producing the wound dressing membrane of claim 16, wherein the collagen-containing preparation comprises a collagen-containing suspension.

18. The method for producing the wound dressing membrane of claim 17, wherein the suspension includes a native collagen.

19. The method for producing the wound dressing membrane of claim 16, wherein the sheet-like structure comprises a mesh.

20. The method for producing the wound dressing membrane of claim 16, further comprising applying the sheet-like structure onto a support.

21. The method for producing the wound dressing membrane of claim 20, wherein the support comprises a collagen membrane.

22. The method for producing the wound dressing membrane of claim 16, further comprising adjusting the collagen-containing preparation to a pH value of greater than 5.5, at least prior to the covering the sheet-like structure with the collagen-containing preparation.

23. The method for producing the wound dressing membrane of claim 16, wherein the drying of the collagen-containing preparation is performed by lyophilization.

24. The method for producing the implant of claim 21, wherein the support comprises a lyophilized skin of animal or a human origin collagen.

25. A wound dressing comprising: a collagen-containing sheet-like structure; and a sheet-like structure made of magnesium or a magnesium alloy, comprising openings, the sheet-like structure made of the magnesium or the magnesium alloy embedded in the collagen-containing sheet-like structure; wherein the wound dressing comprises a geometrically stable bioresorbable membrane.

26. The wound dressing of claim 25, further comprising a support made of a collagen membrane, on which the collagen-containing sheet-like structure is arranged.

27. The wound dressing of claim 25, wherein the sheet-like structure made of the magnesium or the magnesium alloy comprises a mesh.

28. The wound dressing of claim 25, wherein the sheet-like structure made of the magnesium or the magnesium alloy has a thickness from 20 m to 1 mm.

29. The wound dressing of claim 25, wherein the wound dressing is curved.

30. The wound dressing of claim 25, wherein the collagen-containing sheet-like structure comprises a non-woven fabric or a collagen membrane.

31. The wound dressing of claim 25, wherein the sheet-like structure made of the magnesium or the magnesium alloy has a thickness from 50 m to 300 m.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0045] The subject matter of the invention will now be explained in more detail with reference to the drawings of FIGS. 1 to 4.

[0046] With reference to FIGS. 1 to 3, a way of producing an implant according to the invention will be explained by way of example.

[0047] FIG. 4 shows a photograph of an implant.

DETAILED DESCRIPTION OF THE DRAWINGS

[0048] FIG. 1 shows a schematic view of a support 1 which in the present exemplary embodiment consists of a wet-chemically prepared split-skin graft of porcine origin. Thus, this is a collagen membrane.

[0049] A sheet-like structure of magnesium or a magnesium alloy 2 has been placed on the support 1.

[0050] In this exemplary embodiment, the sheet-like structure is provided in the form of a mesh consisting of a magnesium or magnesium alloy film. In this exemplary embodiment, the mesh has diamond-shaped openings.

[0051] The sheet-like structure of magnesium or of a magnesium alloy 2 does not extend as far as to the edge of the support 1.

[0052] As illustrated in FIG. 2, the support 1 and the sheet-like structure of magnesium or of a magnesium alloy are then covered with a collagen-containing preparation 3.

[0053] In the present exemplary embodiment, this is a 0.5 to 5% collagen suspension of porcine origin. The collagen suspension is neutralized using a phosphate buffer before being applied, in particular to a pH value of 70.5.

[0054] The collagen-containing preparation 3 is then spread with a suitable handling tool.

[0055] The so produced composite material is then allowed to rest for a time period between 15 and 120 minutes until the support 1 is well moistened.

[0056] Subsequently, lyophilization is performed over a period of 6 hours to 5 days.

[0057] FIG. 3 now shows a schematic sectional view of the produced composite material.

[0058] This consists of the support 1, on which the sheet-like structure of magnesium or of a magnesium alloy 2 is now embedded in a collagen non-woven fabric 4 which has been formed from the collagen-containing preparation.

[0059] The collagen non-woven fabric 4 at the same time provides a firm bond to the support 1.

[0060] FIG. 4 is a photograph of a composite material according to the invention, in which the different layers are shown torn apart.

[0061] The support in the form of a collagen membrane can be seen, as well as the collagen non-woven fabric 4 torn off therefrom, with a mesh 5 of magnesium embedded therein.

[0062] The invention permits to provide, in a straightforward way, a geometrically stable bioresorbable membrane which is particularly suitable, inter alia, for covering defect sites in the bone/jaw region, without tendency of the composite material to sink in.