Three Dimensional Healing Kit

Abstract

Invention; is about the kit that enables three-dimensional healing with the platelet-rich fibrin framework support used in hard and soft tissue healing.

Claims

1. It is the three-dimensional healing kit, and characterized by a network structured apparatus (1.1), fibrin generation apparatus (1) containing the carrier rod (1.2) and fibrin compression apparatus (2).

2. It is the fibrin compression apparatus (2) mentioned in claim 1, and characterized by a piston (2.1), a container (2.2) the carrier rod centralizer (2.3).

3. It is the network structured apparatus (1.1) mentioned in claim 1, and characterized by comprising at least one layer.

4. It is the network structured apparatus (1.1) mentioned in claim 1, and characterized by the fact that it comprises pores thorough which all elements of the blood can pass during centrifugation.

5. It is the network structured apparatus (1.1) mentioned in claim 1, and characterized by the fact that it contains the agents (calcium phosphate compounds, titanium, collagen, Bioceramics and resorbable polymers) that accelerate the formation of fibrin.

6. It is the network structured apparatus (1.1) mentioned in claim 1, and characterized by the fact that it has a structure that can be shaped in accordance with the surface where it will be applied.

7. It is the container (2,2) mentioned in claim 2, and characterized by a removable bottom base (2.2.1) it has.

8. It is the container (2,2) mentioned in claim 2, and characterized by having different geometric shapes.

9. It is the piston (2.1) mentioned in claim 2, and characterized by being different geometric shapes that can give suitable form to the surface where fibrin will be placed.

10. It is the layer mentioned in claim 3 and it is characterized by being a part that accelerates and enhances organic and inorganic fibrin formation suitable to the tissue to be applied, and enhances the auxiliary wound healing agents (implants, calcium phosphate compounds, autogenous or non-autogenous graft materials, bone morphogenetic proteins, fibroblast growth factors, bioactive agents such as PDGF, stem cells, puliripotent cells, fibrin or collagen obtained from the patient himself).

11. It is the layer mentioned in claim 3 and it is characterized by being in the suitable form and size of the material to be placed into its mesh.

Description

MEANINGS OF THE FIGURES

[0060] FIG. 1. Sectional View of the Fibrin Formation Apparatus

[0061] FIG. 2. Fibrin Compression Apparatus Mounted View

[0062] FIG. 3. Bottom View of Fibrin Compression Apparatus

[0063] FIG. 4. Sectional View of Fibrin Compression Apparatus

[0064] FIG. 5. Top View of Fibrin Compression Container

[0065] FIG. 6. Sectional View of Fibrin Compression Container

[0066] FIG. 7. The View of Implant Placed into the Apparatus in Network Structure

[0067] Equivalents of the specified part numbers are given below. [0068] 1. Fibrin generation apparatus [0069] 1.1. Apparatus in the Network Structure [0070] 1.1.1. Layer [0071] 1.1.2. Clamp [0072] 1.2. Carrier Rod [0073] 2. Fibrin Compression Apparatus [0074] 2.1. Piston [0075] 2.2. Container [0076] 2.2.1. Removable Lower Base [0077] 2.3. Carrier Rod Centralizer

DETAILED DESCRIPTION OF THE INVENTION

[0078] Invention is composed of fibrin generation apparatus (1) and Fibrin Compression Apparatus (2). Fibrin generation apparatus (1) consists of a network structured apparatus (1.1) with at least one layer (1.1.1) and clamps (1.1.2), and a carrier rod (1.2). Fibrin compression apparatus (2) is characterized by a piston (2.1) and container (2.2) containing a removable lower base (2.2.1), and a carrier rod centralizer (2.3).

[0079] Through the fibrin generation apparatus (1) inserted into the tube, shapeable fibrin is formed on the network structured apparatus. There is a network structured apparatus (1.1) containing at least one layer (1.1.1) attached with the help of clamps (1.1.2) to the end of the carrier rod (1.2). Network structured apparatus (1.1) consists of at least one layer (1.1.1). Calcium phosphate compounds, autogenous or non-autogenous graft materials, bone morphogenic proteins, fibroblast growth factors, bioactive agents such as PDGF, stem cells, puliripotent cells and fibrin or collagen obtained from the patient himself that accelerate fibrin formation before or after centrifugation and provide 3D wound healing can be inserted between these layers. These layers (1.1.1) can be shaped according to the surface to apply the fibrin. Upon completion of the centrifugation, apparatus forming fibrin (1) removed from the tube is attached to the carrier rod centralizer (2.3) of the fibrin compression apparatus (2) with the help of a carrier rod (1.2). When the piston (2.1) fixed on the carrier rod (1.2) is pushed, it will compress the network structured apparatus (1.1) pushing towards the removable lower base (2.2.1) of the container (2.2). Thus, compressed fibrin will be collected on the removable bottom base (2.2.1) of the container (2.2). A thick fibrin in layers can be formed by repeating this process many times. By changing the form of the piston (2.1) and the removable lower base (2.2.1), the shape of the fibrin can also be changed at this stage. Calcium phosphate compounds, autogenous or non-autogenous graft materials, bone morphogenic proteins, fibroblast growth factors, bioactive agents such as PDGF, stem cells, puliripotent cells, fibrin or collagen obtained from a patient himself can be inserted between the fibrin layers. These agents added according to the intended use will make fibrin more advantageous. Even this structure can act as a matrix to create artificial organs. By removing the removable bottom base (2.2.1) of the container (2.2), fibrin-based structure can be removed and used. Coating the fibrin-carrier rod (1.2) and the inside of the tube with calcium phosphate will accelerate the fibrin formation.

[0080] By inserting stem cells, autogenous and bioactive grafts into the center (1.1.1) of network structured apparatus (1.1), three dimentional healing will be possible providing improvement from fibrin towards tissues beside healing from the known wound towards fibrin.

[0081] Considering that the mechanism of coagulation and healing are different in the soft tissues and bone tissues, the fibrin to be used in these areas should be prepared according to different needs. Platelet-rich fibrin prepared nowadays is obtained by centrifuging the blood taken from the person in the glass or titanium tubes. The obtained platelet-rich fibrin is applied directly to the bone or soft tissues. This situation leads to less obtained gain. The healing in the healing model of the fibrins obtained through known technique occurs from tissue towards fibrin and when tissue absorbs fibrin in time. Stem cells, autologous grafts and bioactive grafts to be placed into the center of our invention with a layered structure can carry out three-dimensional model of healing.

[0082] This inventive kit is characterized by a network structured apparatus with at least one layer composed of biocompatible materials (calcium phosphate, titanium/titanium alloy, or calcium phosphate-coated titanium wire, bioceramics, resorbable polymers, etc.). The network structured apparatus can completely be resorbed or can remain biocompatible in tissue. The effect obtained from the treatment can be increased by putting auxiliary agents that help wound healing, accelerate and enhance organic and inorganic fibrin formation suitable to the tissue to be applied fibrin between the layers of fibrin formed in layers in the compression apparatus. These agents can be calcium phosphate compounds, autogenous or non-autogenous graft materials, bone morphogenetic proteins, growth factors, bioactive agents such as PDGF, stem cells, puliripotent cells, fibrin or collagen obtained from the patient himself. In addition, with the stem cells and autogenous grafts suitable to the tissue to be placed in the center of layers, three dimentional healing can be achieved from tissue to fibrin and from fibrin center to tissue. This will speed up the healing process.

[0083] The result obtained from the treatment may be increased by putting auxiliary agents that help wound healing, promote the formation and quality of organic and inorganic fibrin suitable to the tissue to be applied. These agents are calcium phosphate compounds, autogenous or autologous without graft material, bone morphogenetic proteins, growth factors, bioactive agents, such as PDGF, stem cells, puliripotent cells, fibrin or collagen obtained from the patient himself. In addition, the center layer of tissue with stem cells or autologous graft tissue to be appropriate fibrin may be provided with accurate three-dimensional tissue recovery from fibrin center. This will speed up the healing process.

[0084] The fixation of platelet-rich fibrin in both soft tissue and bone tissue is rather a huge problem. Delicate and flabby structured platelet-rich fibrin can be very quickly deformed. In addition, it is highly difficult for a physician to shape it according to the form of the area to be applied. Because it is important to place the bottom part where stem cells are dense to the recovery surface during the fibrin formation and to remain there stable for the treatment efficiency.

[0085] Network structured apparatus makes it possible for the physician to form it suitable to the area to be applied. Thus, the fibrin form that will occur on the network structured apparatus can be adjusted to the recovery surface form accordingly. In addition, during the fibrin fixation to this surface, suturing from network structure to the soft tissue or screwing it onto the hard (bone) tissue will cease to be a problem. Thus, the recovery surface will be merged with the surface heavily densed with fibrin stem cells in a stable manner.

[0086] The fact that network structured apparatus can be installed and uninstalled with the aid of a bead seat to the carrier rod is the convenience for the physician during use. Fibrin can be removed from the tube very easily and can be moved into the fibrin compression apparatus. He can use the platelet-rich fibrin right away taking it easily and without the risk of distortion the form from the tube or he can use it compressing in the compression container. The body of the network structure comprises pores the thorough which all elements of the blood can pass during centrifugation. It is not certainly in the selectively permeable membrane structure. It has the space that allows all blood elements to pass, and does not prevent the formation of fibrin. Its function is to form a frame and to hold the fibrin inside that will create the materials to be added. The network between the layers of the network structured apparatus will be woven in a suitable form and size of the material to be placed into the network layer between the layers of the network structured apparatus. More than one network structured apparatus can be connected to each other or the fibrin formed can provide connection as well. The network structured apparatus can be constructed in accordance with the geometric structure of the tube the body of which it is located in.

[0087] The implants can be coated with PRF stably by placing the implants to be coated with PRF between the layers (1.1.1) of network structured apparatus (1.1).

[0088] Network structured apparatus wraps around the implant without contacting the implant and fixing on the implant, and it allows the formed fibrin to remain stably around the implant. Network structured apparatus is fixed to the implant from different parts. Still, materials to promote and guide healing are added between the network structured apparatus and implant. Network structured apparatus will provide the required primary stability while the implant is placed into the body by receiving support from the walls of the space where the implant will be located, and immobilizing the implant. Thus, the fibrin thickness between the implant and the network structure is maintained, and the effect of fibrin on the healing and osseointegration is increased. Therefore, the adaptation and improvement process of the implant to the area where it is located will be positively affected. In parallel to the development of centrifugal technology, the size of the implants will cease to be a problem.