CASSETTE HAVING AN INTEGRATED FILTER AND BYPASS

Abstract

A fluid processing system for controlling fluid flow comprising a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette, an inlet port in communication with one or more of the defined passageways and an inlet side of the filter receptacle, an outlet port in communication with an outlet side of the filter receptacle, and a filter medium disposed within the filter receptacle between the inlet port and outlet port.

Claims

1. A fluid processing system for controlling fluid flow, comprising: a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette, an inlet port in communication with one or more of the defined passageways and an inlet side of the filter receptacle; an outlet port in communication with an outlet side of the filter receptacle; and a filter medium disposed within the filter receptacle between the inlet port and outlet port.

2. The fluid processing system of claim 1, wherein the filter medium is a leukoreduction filter.

3. The fluid processing system of claim 1, wherein the first and second portions of the cassette are disposed laterally to each other in substantially the same plane.

4. The fluid processing system of claim 1, wherein the first and second portions of the cassette are disposed generally parallel to one another within substantially different planes.

5. The fluid processing system of claim 1, wherein the inlet port is disposed closer in a z-axis direction relative to the filter receptacle and relative to the outlet port to a durable hardware supporting the cassette.

6. A fluid processing system for controlling fluid flow, comprising: a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette; an inlet port in communication with one or more of the defined passageways and an inlet side of the filter receptacle; a first outlet port in communication with an outlet side of the filter receptacle; a filter medium disposed within the filter receptacle between the inlet port and the first outlet port; and a bypass passageway in communication with the inlet port and a second outlet port, wherein fluid flowing through the bypass passageway does not make contact with the filter medium.

7. The fluid processing system of claim 6, wherein the first and second outlet ports comprise the same port.

8. The fluid processing system of claim 6, wherein the first and second outlet ports comprise different ports.

9. The fluid processing system of claim 6, wherein the filter medium is a leukoreduction filter.

10. The fluid processing system of claim 6, wherein the first and second portions of the cassette are disposed laterally to each other in substantially the same plane.

11. The fluid processing system of claim 6, wherein the first and second portions of the cassette are disposed generally parallel to one another within substantially different planes.

12. The fluid processing system of claim 6, wherein the inlet port is disposed closer in a z-axis direction relative to the filter receptacle and relative to the first outlet port to a durable hardware supporting the cassette.

13. The fluid processing system of claim 10, further comprising a valve disposed between the inlet port and the bypass passageway.

14. The fluid processing system of claim 13, wherein the cassette is configured to direct fluid flow to the bypass passageway when the valve is open and direct fluid flow to the filter receptacle when the valve is closed.

15. The fluid processing system of claim 11, further comprising a valve disposed between the inlet port and the bypass passageway.

16. The fluid processing system of claim 11, further comprising a valve disposed between the first outlet port and the filter receptacle.

17. A method for transferring fluid through a fluid flow path, comprising: providing a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette; providing an inlet port in communication with one or more of the defined passageways and an inlet side of the filter receptacle; providing a first outlet port in communication with an outlet side of the filter receptacle; providing a filter medium disposed within the filter receptacle between the inlet port and the first outlet port; and providing a bypass passageway in communication with the inlet port and a second outlet port, wherein fluid flowing through the bypass passageway does not make contact with the filter medium.

18. The method of claim 17, furthering comprising the filter medium being formed of a melt-blown, nonwoven, fibrous material.

19. The method of claim 17, furthering comprising the filter medium being sealed hermetically at its edges to walls of the filter receptacle.

20. The method of claim 17, furthering comprising forming the cassette and the defined passageways by plastic injection molding.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Features, aspects, and advantages of the present embodiments will become apparent from the following description, appended claims, and the accompanying exemplary embodiments shown in the drawings, which are briefly described below.

[0010] FIG. 1 is a perspective view of a blood processing system employing a durable processing device and a disposable fluid flow circuit, according to an exemplary embodiment;

[0011] FIGS. 2A and 2B are top and bottom perspective views of various components of a cassette having an integrated leukoreduction filter, according to an exemplary embodiment;

[0012] FIGS. 3A and 3B are top and bottom perspective views of a cassette having an integrated leukoreduction filter disposed substantially lateral to the cassette's defined fluid passageways, according to an exemplary embodiment;

[0013] FIG. 3C is a bottom perspective view of the cassette in FIGS. 3A and 3B having covers disposed on the bottom of the cassette body, according to an exemplary embodiment;

[0014] FIG. 4 is a schematic diagram of a cassette having an integrated leukoreduction filter and an integrated bypass mechanism, according to an exemplary embodiment; and

[0015] FIG. 5 is a bottom perspective view of a cassette having an integrated leukoreduction filter and an integrated bypass mechanism, according to another exemplary embodiment.

DETAILED DESCRIPTION

[0016] There are several aspects of the present subject matter which may be embodied separately or together in the devices and systems described and claimed below. These aspects may be employed alone or in combination with other aspects of the subject matter described herein, and the description of these aspects together is not intended to preclude the use of these aspects separately or the claiming of such aspects separately or in different combinations as set forth in the claims appended hereto.

[0017] Some embodiments may allow for a leukofilter to be integrated into one or more cassettes of a disposable fluid circuit.

[0018] Some embodiments may reduce the number of tubing segments required to manufacture a disposable fluid circuit.

[0019] There have been continuing efforts to automate the apparatus and systems used in the post-collection processing of whole blood, and an automated blood component separator for such post-collection processing may be employed. One class of such automated separators employs relatively rotating surfaces, at least one of which carries a porous membrane. An example of such a membrane separator is disclosed in PCT Patent Application Publication No, WO 2014/039086 A1, which is incorporated by reference in its entirety, although any suitable membrane separator may be used. Another class employs a centrifuge that utilizes centrifugal separation principles. An exemplary centrifugal separator is disclosed in U.S. Pat. No, 5,868,696, which is incorporated by reference in its entirety, although any suitable centrifugal separator may be used.

[0020] Both membrane separation and centrifugal separation systems may involve a durable processing system or device used in combination with a disposable processing set or circuit. The durable processing system may include a pump assembly that interacts with one or more of the components of the disposable circuit to draw blood or other bodily fluid from a blood source and move the blood or bodily fluid to another location within the disposable circuit by moving fluid through a fluid flow path.

[0021] One component of the disposable circuit that interacts with the pump assembly may be a molded plastic piece commonly referred to as a cassette. As used herein, the term cassette refers to a component of a fluid processing system that includes one or more defined fluid passageways. The cassette may be secured to a cassette holder or cassette station of the durable equipment, with a flexible sheeting or diaphragm of the cassette facing the durable equipment. The cassette holder or cassette station may include a number of valve actuators that selectively press against the flexible diaphragm/sheeting for opening and closing valve stations of the cassette, thereby controlling which of the fluid passageways are connected to each other and directing the fluid between any of a number of sources and destinations. Flexible tubing loops connected to select edges of the cassette may be received within peristaltic pump stations having rollers that press against the loops and rotate to move fluid through the cassette (and through the other components of the disposable circuit). An exemplary cassette is disclosed in U.S. Pat. No. 5,868,696, which is incorporated by reference herein in its entirety, although any suitable cassette may be used.

[0022] FIG. 1 depicts a blood processing system, generally at 10, which includes a durable reusable processing device 12 and a disposable fluid flow circuit 14 for processing collected whole blood. The illustrated blood processing device 12 includes associated pumps, valves, sensors, displays and other apparatus for configuring and controlling flow of blood and additive solution through the disposable circuit. The device and the processing may be directed by an internal controller that includes a programmable microprocessor automatically controlling the operation of the pumps, valves, sensors, etc.

[0023] The processing device 10 may include a user input and output touch screen 16, a pump station including a whole blood pump 18, an RBC pump 20 and an additive solution pump 22, blood separator mounting station and drive unit 24, tubing clamps 28a-28d, sterile connection or docking devices 30a, 30b, one or more tubing clamps 32, and hematocrit sensor 34. The processing device may also include hangers 38a-d, each associated with a weight scale, for suspending the various containers of the disposable fluid circuit.

[0024] The fluid flow circuit 14 may include an additive solution container 40 and associated fluid flow tubing 42 for withdrawing the additive solution, a whole blood container 44 and associated fluid flow tubing 46 for withdrawal of collected whole blood from the container, and a processing module that includes pump cassette 48, separator 50 (e.g., spinning membrane separator, separation chamber placed within a centrifuge), red blood cell (RBC) container 52, plasma container 54, and associated connecting tubing. The pump cassette 48 may route the fluid flow through tubing loops 21 that extend from the cassette, and each loop may be uniquely positioned to engage a particular one of the pumps 18, 20, and 22. The tubing may extend through the cassette or the cassette may have pre-formed fluid flow paths that direct the fluid flow.

[0025] FIGS. 2A and 2B show top and bottom perspective views of the different components of one embodiment of a cassette 48a having an integrated leukoreduction filter. A rigid cassette body 71 may comprise a plurality of defined fluid passageways 73 in communication with ports 25 and 26 accessible from the outside the cassette 48a. The rigid cassette body 71 and its passageways 73 may be formed by plastic injection molding methods, although any suitable material and/or manufacturing methods may be used. A flexible sheeting or diaphragm 61 may cover the bottom of the cassette body 71, referring to the side of the cassette body 71 facing the durable equipment 12 of FIG. 1. The flexible sheeting 61 may be made of any suitable flexible material, such as PVC foil, amenable to be pressed by valve actuators of the durable equipment 12, allowing control of which of the fluid passageways 73 are open, closed, and/or connected to each other.

[0026] Referring to FIG. 2A, a rigid component 75 may serve to divide the bottom portion of the cassette body 71 comprising the fluid passageways 73 and the top portion of the cassette body 71 forming a receptacle 76 for a leukofilter medium 80 to fit therewithin. The rigid component 75 may be made by the same method, e.g., plastic injection molding, as the cassette body 71, although any suitable material and/or manufacturing methods may be used. Within the receptacle 76 may be fitted a leukofilter medium 80 adapted to remove or reduce the number of leukocytes from the fluid to be filtered. The fluid to be filtered, e.g., red blood cell suspension, may enter the receptacle 76 through an inlet port 78 in communication with one or more of the fluid passageways 73 underneath the rigid component 75 of the cassette body 71. The leukofilter medium 80 may be sealed hermetically at its edges 80a to the receptacle walls 72 formed by the cassette body 71 to ensure that the fluid to be filtered passes through the leukofilter medium 80. The leukofilter medium 80 may alternatively or additionally be sealed hermetically at its surface 80b (FIG. 2B) to the rigid component 75 of the receptacle 76. An embodiment in which the leukofilter medium is disposed substantially above or below the plane of the defined fluid passageways (substantially same x/y-position and different z-position) may be described as a stacked configuration.

[0027] The leukofilter medium 80 may be formed of any suitable material but, in one exemplary embodiment, may be formed of a melt-blown, nonwoven, fibrous material, such as a polybutylene terephthalate (PBT) material. The leukofilter medium 80 may be formed from a single or a plurality of layers, which may be either substantially identical or differently configured. For example, a multi-layer leukofilter layer may be comprised of a plurality of fibrous layers, a plurality of non-fibrous layers, and/or a combination of fibrous layers and non-fibrous layers. Examples of various leukifiltration media are disclosed in US Patent Application Publication Nos. 2015/0265758, 2015/0265954, and 2015/0265755, which are incorporated by reference in their entireties, although any suitable leukofiltration medium may be used.

[0028] A hard, rigid, or semi-rigid component 90 may cover or enclose the top of the cassette body 71, referring to the side of the cassette body 71 facing away from the durable equipment 12 of FIG. 1. The component 90 may enclose or contain the leukofilter medium 80 within the receptacle 76 of the cassette body 71, sealing the medium 80 within the receptacle 76. The component 90 may comprise an outlet port 91 in communication with the filtrate leaving the leukofilter medium 80.

[0029] FIGS. 3A and 3B show an alternate embodiment of a cassette 48b having an integrated leukoreduction filter disposed substantially lateral to the defined fluid passageways. The embodiment in which the leukofilter is disposed substantially lateral to the plane of the defined fluid passageways (substantially same z-position and different x/y-position) may be described as a lateral configuration. FIG. 3A shows the top of the cassette 48b, and FIG. 3B shows the bottom of the cassette 48b. A rigid cassette body 71b may comprise a plurality of defined fluid passageways 73b in communication with ports 25b and 26b accessible from the outside the cassette 48b. The rigid cassette body 71b may also form a receptacle 76b lateral to the plurality of defined fluid passageways 73b. The receptacle 76b may be configured to receive a leukofilter medium such as the medium 80 described above. Such as described with regard to FIGS. 2A and 2B, the rigid cassette body 71b, its passageways 73b, and the receptacle 76b may be formed by plastic injection molding methods, although any suitable material and/or manufacturing methods may be used.

[0030] The fluid to be filtered, e.g., red blood cell suspension, may enter the receptacle 76b through an inlet port 78b (see FIG. 3B) in communication with one or more of the fluid passageways 73b of the cassette body 71b. As described in connection with FIGS. 2A and 2B, the leukofilter medium may be sealed hermetically at its edges to the receptacle walls 72b formed by the cassette body 71b to ensure that the fluid to be filtered does not escape through or between the edges of the medium and the receptacle walls 72b. The inlet port 78b may be disposed slightly below the receptacle 76b in a z-axis direction closer to the durable equipment 12 of FIG. 1 to avoid the seal between the leukofilter medium and the receptacle walls 72b. The top of the cassette body 71b proximate to the receptacle 76b may comprise an outlet port 91b in communication with the filtrate leaving the leukofilter medium.

[0031] FIG. 3C shows the bottom of the cassette 48b having sheetings 61b and 75b disposed on the bottom of the cassette body 71b. The flexible sheeting 61b may be made of the same flexible material, e.g., PVC foil, as sheeting 61 in FIGS. 2A and 2B, amenable to be pressed by valve actuators of the durable equipment 12, allowing control of which of the fluid passageways 73 are open, closed, and/or connected to each other. The sheeting 75b enclosing the receptacle 76b may be comprised of the same material as flexible sheeting 61b or may be comprised of a rigid material, such as that of the cassette body 71b. In an embodiment in which the sheetings 75b and 61b are comprised of the same material, the sheetings may be formed from a single sheet of material covering both the defined passageways 73b and the receptacle 76b, or the sheetings may be formed from different sheets of material.

[0032] In an event in which the particles, e.g., red blood cells, retained by the filter medium become saturated within the medium and the medium is no longer passable by fluid, it may be desirable to have a bypass mechanism so that fluid does not have to pass through the medium in order for the fluid procedure to continue. It may also be desirable to have a bypass mechanism for when reverse flow is desired without filtrate that has just passed through the medium going backwards into the filter medium.

[0033] Turning to FIG. 4, a schematic diagram is shown of one embodiment of a cassette having an integrated leukoreduction filter and an integrated bypass mechanism. The embodiment of FIG. 4 shows a cassette 48c having a filter medium 80c disposed in a stacked configuration, similar to the configuration shown in FIGS. 2A and 2B. In one embodiment, the defined fluid passageways may be disposed on a plane closer to the durable equipment 12 (FIG. 1) than that of the filter medium 80c. The fluid to be filtered, e.g., red blood cell suspension, may enter a receptacle 76c housing the filter medium 80c through an inlet port 78c in communication with one or more of the fluid passageways. The inlet port 78c may also be in communication with a bypass 95, which in turn, may be in communication with an outlet port 91c, which is also in communication with the filtrate of the filter medium 80c. A valve 79a may be disposed between the inlet port 78c and the bypass 95 to control direction of fluid flow. The valve 79a may be open or closed, depending on whether it is desired for fluid to enter receptacle 76d through inlet port 78c or for fluid to bypass the filter medium 80c by entering bypass 95 and out of the cassette 48c via outlet port 91c. The bypass mechanism may be activated by opening valve 79a. Once valve 79a is open, fluid entering the inlet port 78c may be directed to the bypass 95 rather than the filter medium due to bypass 95 providing the pathway of less resistance than the pathway through the filter medium. A second valve 79b may optionally be disposed between the outlet port 91c and the receptacle 76c containing the filtrate. When flow coming out of outlet port 91c needs to be reversed, filtrate that has just left the filter medium 80c may be reversed into the cassette 48c by closing valve 79b and opening valve 79a. Due to the tendency of fluid to flow in the path of least resistance, fluid being reversed into the cassette 48c will tend to flow from the outlet port 91c to the bypass 95 rather than back into the filter medium 80c even without the presence of valve 79b, but valve 79b may optionally be incorporated into the cassette 48c as a failsafe. Valve 79b may be disposed along a passageway 73c in communication between filter medium 80c and the outlet port 91c. The passageway 73c may be disposed at an xiy-position substantially not overlapping with the x/y-position of the filter medium 80c to accommodate room in the cassette for a bypass mechanism.

[0034] FIG. 5 shows an alternate embodiment of a cassette having an integrated leukoreduction filter and an integrated bypass mechanism. The embodiment of FIG. 5 shows a cassette 48d having a receptacle 76d configured to receive a filter medium (not illustrated) disposed in a lateral configuration at substantially the same plane as the defined fluid passageways 73d. The fluid to be filtered, e.g., red blood cell suspension, may enter the receptacle 76d housing the filter medium through an inlet port 78d in communication with one or more of the fluid passageways underneath the filter medium. The inlet port 78d may be in communication with a cassette inlet port 25d, into which fluid to be filtered may enter. The cassette inlet port 25d may be in communication with a valve 79d, which may be open or closed, depending on whether it is desired for fluid to enter receptacle 76d through inlet port 78d or for fluid to bypass the filter medium by entering bypass passageway 95d and out of the cassette 48d via cassette outlet port 25e. The bypass mechanism may be activated by opening valve 79d. Once valve 79d is open, fluid entering the inlet port 25d may be directed to the bypass 95d rather than the filter medium due to bypass 95d providing the pathway of less resistance than the pathway through the filter medium.

[0035] Without limiting the foregoing description, in accordance with a first aspect of the subject matter herein, there is provided a fluid processing system for controlling fluid flow. The system includes a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette. An inlet port is in communication with one or more of the defined passageways and an inlet side of the filter receptacle. An outlet port is in communication with an outlet side of the filter receptacle, and a filter medium is within the filter receptacle between the inlet port and outlet port.

[0036] In accordance with a second aspect which may be used or combined with the immediately preceding aspect, the filter medium is a leukoreduction filter.

[0037] In accordance with a third aspect which may be used or combined with any of the preceding aspects, the first and second portions of the cassette are disposed laterally to each other in substantially the same plane.

[0038] In accordance with a fourth aspect which may be used or combined with any of the preceding aspects, the first and second portions of the cassette are disposed generally parallel to one another within substantially different planes.

[0039] In accordance with a fifth aspect which may be used or combined with any of the preceding aspects, the inlet port is disposed closer in a z-axis direction relative to the filter receptacle and relative to the outlet port to a durable hardware supporting the cassette.

[0040] In accordance with a sixth aspect of the subject matter herein, there is provided a fluid processing system for controlling fluid flow. The system comprises a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette. An inlet port is in communication with one or more of the defined passageways and an inlet side of the filter receptacle. A first outlet port is in communication with an outlet side of the filter receptacle. A filter medium is disposed within the filter receptacle between the inlet port and the first outlet port. A bypass passageway is in communication with the inlet port and a second outlet port, and fluid flowing through the bypass passageway does not make contact with the filter medium.

[0041] In accordance with a seventh aspect which may be used or combined with the immediately preceding aspect, the first and second outlet ports comprise the same port.

[0042] In accordance with an eighth aspect which may be used or combined with the sixth or seventh aspect, the first and second outlet ports comprise different ports.

[0043] In accordance with a ninth aspect which may be used or combined with any of the preceding aspects, the filter medium is a leukoreduction filter.

[0044] In accordance with a tenth aspect which may be used or combined with any of the preceding aspects, the first and second portions of the cassette are disposed laterally to each other in substantially the same plane.

[0045] In accordance with an eleventh aspect which may be used or combined with any of the preceding aspects, the first and second portions of the cassette are disposed generally parallel to one another within substantially different planes.

[0046] In accordance with a twelfth aspect which may be used or combined with any of the preceding aspects, the inlet port is disposed closer in a z-axis direction relative to the filter receptacle and relative to the first outlet port to a durable hardware supporting the cassette.

[0047] In accordance with a thirteenth aspect which may be used or combined with the tenth aspect, a valve is disposed between the inlet port and the bypass passageway.

[0048] In accordance with a fourteenth aspect which may be used or combined with the thirteenth aspect, a valve is disposed between the inlet port and the bypass passageway.

[0049] In accordance with a fifteenth aspect which may be used or combined with the tenth through fourteenth aspects, a valve is disposed between the inlet port and the bypass passageway.

[0050] In accordance with a sixteenth aspect which may be used or combined with the eleventh through fifteenth aspects, a valve is disposed between the first outlet port and the filter receptacle.

[0051] In accordance with a seventeenth aspect of the subject matter herein, there is provided a method for transferring fluid through a fluid flow path. The method comprises providing a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette. An inlet port is in communication with one or more of the defined passageways and an inlet side of the filter receptacle. A first outlet port is in communication with an outlet side of the filter receptacle. A filter medium is disposed within the filter receptacle between the inlet port and the first outlet port. A bypass passageway is in communication with the inlet port and a second outlet port, and fluid flowing through the bypass passageway does not make contact with the filter medium.

[0052] In accordance with an eighteenth aspect which may be used or combined with the immediately preceding aspect, the filter medium is formed of a melt-blown, nonwoven, fibrous material.

[0053] In accordance with a nineteenth aspect which may be used or combined with the seventeenth and eighteenth aspects, the filter medium is sealed hermetically at its edges to walls of the filter receptacle.

[0054] In accordance with a twentieth aspect which may be used or combined with the seventeenth through nineteenth aspects, the cassette and the defined passageways are formed by plastic injection molding.

[0055] The embodiments disclosed herein are for the purpose of providing a description of the present subject matter, and it is understood that the subject matter may be embodied in various other forms and combinations not shown in detail. Therefore, specific embodiments and features disclosed herein are not to be interpreted as limiting the subject matter as defined in the accompanying claims.