Skin radiation apparatus and method
09901746 ยท 2018-02-27
Assignee
Inventors
- Giovanna WAGENAAR CACCIOLA (EINDHOVEN, NL)
- Arnd Ritz (Heinsberg, DE)
- VINCENT STEFAN DAVID GIELEN (EINDHOVEN, NL)
- Ian Edward Ashdown (West Vancouver, CA)
- Damien Loveland (Richmond, CA, US)
Cpc classification
A61B2018/20355
HUMAN NECESSITIES
A61B2018/20361
HUMAN NECESSITIES
A61N5/01
HUMAN NECESSITIES
International classification
Abstract
The present invention relates to a skin radiation apparatus and method. The apparatus includes a photon radiation unit for generating a line-shaped radiation pattern that extends in a first direction; a movement facility for moving the line shaped radiation pattern in a second direction transverse to the first direction; a detection unit for detecting a skin condition profile; and a control unit for controlling the line-shaped radiation pattern, dependent on the detected skin condition profile.
Claims
1. A skin radiation apparatus comprising: a photon radiation emitter configured to generate a line-shaped radiation pattern extending in a first direction, the photon radiation emitter comprising a photon radiation source having a plurality of elements, each configured to simultaneously generate a respective portion of the line-shaped pattern, wherein the line-shaped radiation pattern is generated without requiring any movement of the photon radiation emitter, a movement facility configured to cause movement of the line-shaped radiation pattern in a second direction transverse to the first direction, a skin condition detector configured to detect a skin condition profile, a controller configured to determine a power density distribution for the line-shaped radiation pattern, that simultaneously has multiple different positive power densities, and is dependent on: the skin condition profile detected by the skin condition detector, a maximum power density above which skin damage would occur, and a minimum power density below which the treatment has no therapeutic effect, the controller being further configured to control the photon radiation emitter to generate the determined power density distribution of the line-shaped radiation pattern having the multiple different positive power densities along the first direction.
2. The skin radiation apparatus of claim 1, wherein the skin condition detector is configured to detect a skin condition profile in a scan region, and wherein the movement facility is configured to cause the line-shaped radiation pattern to traverse the scan region and wherein the controller controls the power density distribution depending on the skin condition profile detected for the scan region.
3. The skin radiation apparatus of claim 2, wherein the line-shaped radiation pattern is applied to a person's skin, the skin radiation apparatus comprising: movement detector configured to detect any movement of the person not caused by the movement facility, and generate a corresponding movement indication signal, wherein the controller is configured to control the power density distribution based on the skin condition profile detected for the scan region and on the basis of the movement indication signal.
4. The skin radiation apparatus of claim 1, wherein the skin condition detector is configured to detect a skin condition profile in a line-shaped detection area.
5. The skin radiation apparatus of claim 4, wherein the line-shaped radiation pattern is targeted at the line-shaped detection area and wherein the movement facility is configured to move the line-shaped detection area to a next position in the second direction after the skin condition profile in the line-shaped detection area has been determined and the line shaped radiation pattern has been applied to the line-shaped detection area.
6. The skin radiation apparatus of claim 4, wherein the skin condition detector is configured to detect a skin condition in a further line-shaped detection area that is positioned ahead in the second direction with respect to a line-shaped radiation area that is irradiated by the line-shaped radiation pattern.
7. The skin radiation apparatus of claim 4, wherein the skin condition detector and the photon radiation emitter are arranged in a common housing that is moved by the movement facility.
8. The skin radiation apparatus of claim 1, further comprising an indication facility for indicating at least one of: a radiation power profile, and a radiation dose profile, scheduled by the controller to be applied at the skin.
9. The skin radiation apparatus of claim 8, further comprising a feedback facility allowing an operator to change at least one of the radiation power profile and the radiation dose profile as scheduled by the controller.
10. The skin radiation apparatus of claim 9, comprising a learning unit for teaching optimal operation of the skin condition detector or controller on the basis of the changes to the radiation power profile and/or the radiation dose profile as indicated by the operator.
11. The skin radiation apparatus of claim 1, comprising a storage facility for storing data related to a therapeutic session.
12. A skin radiation method comprising the acts of: in a skin radiation apparatus: detecting via a skin condition sensor, a skin condition profile of a person's skin, generating via a photon radiation emitter, a line-shaped radiation pattern that extends in a first direction, wherein the generating act comprises utilizing a photon radiation source having a plurality of elements, each element capable of simultaneously providing a respective portion of the line-shaped pattern, wherein the line-shaped radiation pattern is generated without requiring any movement of the photon radiation emitter, moving by a movement facility, the line-shaped radiation pattern in a second direction transverse to the first direction, and controlling via a controller, the photon radiation emitter to generate a power density distribution of the line-shaped radiation pattern having multiple different positive power densities along the first direction based on the detected skin condition profile, a maximum power density above which skin damage would occur, and a minimum power density below which the treatment has no therapeutic effect.
13. The skin radiation method of claim 12, further comprising an act of generating a visible pattern that is isomorphic to at least one of: a scheduled radiation power profile, and a scheduled radiation dose profile, after the skin condition profile is scheduled and before generating the line-shaped radiation pattern.
14. The skin radiation method of claim 13, further comprising an act of changing at least one of: the scheduled radiation power profile, and the scheduled radiation dose profile, upon commands received by the controller from an operator, after generating the visible pattern.
15. The skin radiation method of claim 14, comprising an optimizing operation of the detecting of the skin condition profile, the optimizing operation based on the changes to at least one of: the radiation power profile, and the radiation dose profile, as indicated by the received commands.
16. The skin radiation method of claim 14, comprising an optimizing operation of the generating the line-shaped radiation pattern based on the changes to at least one of: the radiation power profile, and the radiation dose profile, as indicated by the received commands.
17. A skin radiation apparatus comprising: a photon radiation emitter configured to generate a line-shaped radiation pattern extending in a first direction, the photon radiation emitter comprising a photon radiation source having a plurality of radiation source elements, wherein in use, the plurality of the radiation source elements simultaneously provide respective portions of the line-shaped pattern, a movement facility configured to cause movement of the line-shaped radiation pattern in a second direction transverse to the first direction, a skin condition detector configured to detect a skin condition profile, a controller configured to determine a power density distribution for the line-shaped radiation pattern, that simultaneously has at least three different power densities, and is dependent on: the skin condition profile detected by the skin condition detector, a maximum power density above which skin damage would occur, and a minimum power density below which the treatment has no therapeutic effect, the controller being further configured to control the photon radiation emitter to generate the determined power density distribution of the line-shaped radiation pattern having multiple different positive power densities along the first direction.
18. A computer-readable storage-medium that is not a transitory propagating signal or wave, the medium modified by control information including instructions for performing a method for irradiating skin, the method comprising: in a skin irradiation apparatus: detecting via a skin condition sensor, a skin condition profile of a person's skin, generating via a photon radiation emitter, a line-shaped radiation pattern that extends in a first direction, wherein the generating step comprises utilizing a photon radiation source having a plurality of elements, each element capable of simultaneously providing a respective portion of the line-shaped pattern, wherein the line-shaped radiation pattern is generated without requiring any movement of the photon radiation emitter, moving by a moving facility, the line-shaped radiation pattern in a second direction transverse to the first direction, and controlling via a controller, the photon radiation emitter to generate a power density distribution of the line-shaped radiation pattern having multiple different positive power densities along the first direction based on the detected skin condition profile, a maximum power density above which skin damage would occur, and a minimum power density below which the treatment has no therapeutic effect.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) These and other aspects are described in more detail with reference to the drawing. Therein:
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
(11)
(12)
(13)
(14)
DETAILED DESCRIPTION OF EMBODIMENTS
(15) In the following detailed description numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, it will be understood by one skilled in the art that the present invention may be practiced without these specific details. In other instances, well known methods, procedures, and components have not been described in detail so as not to obscure aspects of the present invention.
(16) The invention is described more fully hereinafter with reference to the accompanying drawings, in which embodiments of the invention are shown. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. In the drawings, the size and relative sizes of layers and regions may be exaggerated for clarity.
(17) It will be understood that, although the terms first, second, third etc. may be used herein to describe various elements, components, and/or sections, these elements, components, and/or sections should not be limited by these terms. These terms are only used to distinguish one element, component and/or section from another element, component, and/or section. Thus, a first element, component, and/or section discussed below could be termed a second element, component, and/or section without departing from the teachings of the present invention.
(18) Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.
(19)
(20) Directions x and y are defined by a plane of the skin that is to be irradiated.
(21) The apparatus further comprises a detection unit 30 (
(22) The apparatus further comprises a control unit 40 for controlling a power density distribution for the line-shaped radiation pattern 12 dependent on the skin condition detected by the detection unit 30.
(23) The apparatus may be used in a skin radiation method as follows. First the apparatus detects a skin condition profile of the skin of the patient 1. In this case, as illustrated in
(24) TABLE-US-00001 TABLE 1 Recommended photon radiation dose for treatment of psoriasis Starting dose Increment Final Skin type (mJ/cm.sup.2) (mJ/cm.sup.2) (mJ/cm.sup.2) 1 300 100 2000 2 300 100 2000 3 500 100 2000 4 500 100 2000 5 800 150 5000 6 800 150 5000
(25) Depending on the circumstances a choice may be made whether the dose is to be provided in the form of a relatively short irradiation with a relatively high power density (e.g. for professional applications) or a relatively long irradiation with a relatively low power density (e.g. for home applications). For example, for a skin radiation apparatus for use at home it may be preferred to apply a relatively low power density. An apparatus for consumer applications may for example provide a line-shaped radiation pattern with a maximum power density of 10 mW/cm.sup.2 and may apply a dose of 300 mJ/cm.sup.2 in 30 s. For professional use by medically trained practitioners a line shaped radiation pattern having a significantly higher maximum power density may be applied allowing for a faster treatment, e.g. 50 mW/cm.sup.2 during 6 s or 300 mW/cm.sup.2 during 1 s.
(26) Irradiation with a particular duration may be achieved by a stepwise scanning of the area of the skin to be treated. For example the line shaped radiation pattern is stepwise displaced in the second direction with a stepsize s equal to the width of the radiation pattern each time the required radiation dose is reached. It is not necessary that the step size s with which the line shaped radiation pattern is displaced is equal to the width w of the pattern. The step size s may for example be a fraction of the width w, e.g. equal to half the width w. In this way a spatially relatively uniform radiation dose is reached also if the power density distribution in the second direction is relatively non-uniform, e.g. bell-shaped. When stepping with a step-size s each time interval t.sub.s, an average scanning speed v.sub.s equal to s/t.sub.s is obtained. It is not necessary that the required dose for a particular treatment session is applied in a single scan. Alternatively an accumulated dose may be obtained after a plurality of scans in a session, therewith enabling an intermittent application of radiation. This gives the medical practitioner more freedom in treatment algorithms. For example a dose of 300 mJ/cm.sup.2 is reached with 3 scans at a power density of 100 mW/cm.sup.2 and an exposure time of 1 s each.
(27) Instead of scanning step-wise, the line-shaped radiation pattern may be moved continuously with a velocity v.sub.c. In this case the average exposure time t.sub.exp is w/v.sub.c.
(28) The selection of the width w depends on the requirements of spatial accuracy with which the dose is to be controlled as well as the speed of treatment. A large width w is favorable for a fast treatment, however at the cost of a lower accuracy with respect to the spatial resolution. For practical purposes the width of the line shaped radiation pattern is for example in the range of 0.1 cm to 2 cm. If the width is larger than 2 cm, the spatial resolution with which the radiation can be applied to the surface of the skin becomes too low. A width smaller than 0.1 cm, although possible, would require relatively expensive optical means while not resulting in a more accurate treatment. Moreover, a small width would either require a relatively high power density, which may be dangerous in case of failure of the movement facility, or would result in long treatment times in case a lower power density is applied.
(29) It is noted that the dose to be applied may further be dependent on the severity of the skin disease.
(30) The embodiment of the apparatus shown in
(31)
(32) The apparatus shown in
(33)
(34) The skin radiation apparatus as shown in
(35)
(36) In case the medical practitioner first desires to observe the proposed radiation power profile and/or the radiation dose profile, the apparatus may make a full scan over the area to be treated and gather the required information about the skin condition of the patient, as well as the proposed treatment. Subsequently thereto the results may be shown on a display 56, e.g. a touch screen, and the medical practitioner may be enabled to amend the proposed radiation power profile and/or radiation dose profile by feedback means 60, 61, 62, in the same way as described with reference to the embodiment of
(37)
(38) It is not necessary that the housing 5 with the photon radiation unit 10 is moved stepwise. Alternatively the photon radiation unit 10 may be moved continuously while irradiating. The apparatus may have an interpolation facility 42 to interpolate the power density distribution for the line-shaped radiation pattern 12 between subsequent positions in the second direction y. Alternatively, the control unit 40 may stepwise change the power density distribution in the line-shaped radiation pattern each time the movement has proceeded over a predetermined distance in the second direction y.
(39) The administered photon radiation dose is proportional to the line width w divided by the movement speed v. This is either the continuous speed or the average speed resulting from the stepping process, which is s/t.sub.s, wherein s is the step-size and t.sub.s is the time interval between subsequent steps.
(40) The available time for detecting the skin condition and calculating the required radiation power profile is d/v, wherein d is the distance between the line shaped region 36 for which the skin condition is detected and the line shaped region 15 that is treated with radiation.
(41)
(42)
(43) In the embodiment of
(44) Arithmetical and logical operations carried out by various parts of the apparatus of the control unit 40, by the detection unit 30, and the drivers 140, 144 or 148 may be carried out by dedicated hardware, by software in a programmable processors or by a combination of both.
(45) Although the apparatus and method described above have been described particularly with reference to the treatment of psoriasis, the apparatus and method can alternatively be modified to be suitable for the recognition and treatment of other skin conditions, such as myocosis fungoides, eczema, actinic keratosis, lichen planus etc. For treatment of other skin conditions than psoriasis, other photon radiation wavelengths, wavelength ranges or combinations may be used.
(46) In the claims the word comprising does not exclude other elements or steps, and the indefinite article a or an does not exclude a plurality. A single component or other unit may fulfill the functions of several items recited in the claims.
(47) The mere fact that certain measures are recited in mutually different claims does not indicate that a combination of these measures cannot be used to advantage. Any reference signs in the claims should not be construed as limiting the scope. Further, unless expressly stated to the contrary, or refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).