FUNGICIDAL ACTIVE COMPOUND COMBINATIONS

Abstract

The invention relates to active compound combinations comprising firstly the known fluoxastrobin and secondly further known fungicidal active compounds, which combinations are highly suitable for controlling unwanted phytopathogenic fungi.

Claims

1-8. (canceled)

9. A fungicidally active compound combination comprising fluoxastrobin and at least one fungicidally active carbamate compound.

10. The combination of claim 1 wherein the carbamate is one or more of propamocarb, propamocarb hydrochloride, and propamocarb-fosetyl.

11. The combination of claim 2 wherein the carbamate is propamocarb.

12. The combination of claim 1 wherein the ratio of fluoxastrobin to the at least one active carbamate compound is 1:1 to 1:150.

13. The combination of claim 4 wherein the ratio of fluoxastrobin to the at least one active carbamate compound is 1:1 to 1:100.

Description

EXAMPLES

Example 1

Pyricularia oryzae Test (In Vitro)/Microtiter Plates

[0241] The microtest is carried out in microtiter plates using potato dextrose broth (PDB) as liquid test medium. The active compounds are applied as technical-grade a.i., dissolved in acetone in the case of fluoxastrobin and as a commercially available formulation in the case of silthiofam. For inoculation, a spore suspension of Pyricularia oryzae is used. After 3 days of incubation in the dark and with shaking (10 Hrz) the light transmittance in each filled cavity of the microliter plates is determined using a spectrophotometer.

[0242] 0% means an efficacy which corresponds to the growth in the controls, whereas an efficacy of 100% means that no fungal growth is observed.

[0243] The table below shows clearly that the activity found for the active compound combination according to the invention is greater than the calculated activity, i.e. that a synergistic effect is present.

TABLE-US-00002 TABLE Pyricularia oryzae test (in vitro)/microtest Active compound Active compound application Known: rate in ppm % efficacy fluoxastrobin 0.1 80 silthiofam 0.1 1

[0244] Mixture According to the Invention:

TABLE-US-00003 Active compound Predicted value Mixing application rate Actual calculated using ratio in ppm efficacy Colby's formula fluoxastrobin + silthiofam } 1:1 0.1 + 0.1 } 99 81

Example 2

Rhizoctonia solani Test (In Vitro)/Microtiter Plates

[0245] The microtest is carried out in microtiter plates using potato dextrose broth (PDB) as liquid test medium. The active compounds are applied as technical-grade a.i., dissolved in acetone in the case of fluoxastrobin and as a commercially available formulation in the case of boscalid. For inoculation, a mycelium suspension of Rhizoctonia solani is used. After 4 days of incubation in the dark and with shaking (10 Hrz) the light transmittance in each filled cavity of the microtiter plates is determined using a spectrophotometer.

[0246] 0% means an efficacy which corresponds to the growth in the controls, whereas an efficacy of 100% means that no fungal growth is observed.

[0247] The table below shows clearly that the activity found for the active compound combination, according to the invention is greater than the calculated activity, i.e. that a synergistic effect is present.

TABLE-US-00004 TABLE Rhizoctonia solani test (in vitro)/microtest Active compound Active compound application Known: rate in ppm % efficacy fluoxastrobin 0.1 64 boscalid 0.1 67

[0248] Mixture According to the Invention:

TABLE-US-00005 Active compound Predicted value Mixing application rate Actual calculated using ratio in ppm efficacy Colby's formula fluoxastrobin + boscalid } 1:1 0.1 + 0.1 } 95 88

Example 3

Coriolus versicolor Test (In Vitro)/Microtiter Plates

[0249] The microtest is carried out in microtiter plates using potato dextrose broth (PDB) as liquid test medium. The active compounds are applied as technical-grade a.i., dissolved in acetone. For inoculation, a mycelium suspension of Coriolus versicolor is used. After 3 days of incubation in the dark and with shaking (10 Hrz) the light transmittance in each filled cavity of the microtiter plates is determined using a spectrophotometer.

[0250] 0% means an efficacy which corresponds to the growth in the controls, whereas an efficacy of 100% means that no fungal growth is observed.

[0251] The table below shows clearly that the activity found for the active compound combination according to the invention is greater than the calculated activity, i.e. that a synergistic effect is present.

TABLE-US-00006 TABLE Coriolus versicolor test (in vitro)/microtest Active compound Active compound application Known: rate in ppm % efficacy fluoxastrobin 0.03 24 difenoconazole 0.03 93

[0252] Mixture According to the Invention:

TABLE-US-00007 Active compound Predicted value Mixing application rate Actual calculated using ratio in ppm efficacy Colby's formula fluoxastrobin + difenoconazole } 1:1 0.03 + 0.03 } 99 95

Example 4

Pyricularia oryzae Test (In Vitro)/Microtiter Plates

[0253] The microtest is carried out in microtiter plates using potato dextrose broth (PDB) as liquid test medium. The active compounds are applied as technical-grade a.i., dissolved in acetone. For inoculation, a spore suspension of Pyricularia oryzae is used. After 5 days of incubation in the dark and with shaking (10 Hrz) the light transmittance in each filled cavity of the microtiter plates is determined using a spectrophotometer.

[0254] 0% means an efficacy which corresponds to the growth in the controls, whereas an efficacy of 100% means that no fungal growth is observed.

[0255] The table below shows clearly that the activity found for the active compound combination according to the invention is greater than the calculated activity, i.e. that a synergistic effect is present.

TABLE-US-00008 TABLE Pyricularia oryzae test (in vitro)/microtest Active compound Active compound application Known: rate in ppm % efficacy fluoxastrobin 0.3 86 flutriafol 0.3 6

[0256] Mixture According to the Invention:

TABLE-US-00009 Active compound Predicted value Mixing application rate Actual calculated using ratio in ppm efficacy Colby's formula fluoxastrobin + flutriafol } 1:1 0.3 + 0.3 } 91 87

Example 5

Botrytis cinerea Test (In Vitro)/Microtiter Plates

[0257] The microtest is carried out in microtiter plates using potato dextrose broth (PDB) as liquid test medium. The active compounds are applied as technical-grade a.i., dissolved in acetone in the case of fluoxastrobin and as a commercially available formulation in the case of ipconaxole. For inoculation, a spore suspension of Botrytis cinerea is used. After 3 days of incubation in the dark and with shaking (10 Hrz) the light transmittance in each filled cavity of the microtiter plates is determined using a spectrophotometer.

[0258] 0% means an efficacy which corresponds to the growth in the controls, whereas an efficacy of 100% means that no fungal growth is observed.

[0259] The table below shows clearly that the activity found for the active compound combination according to the invention is greater than the calculated activity, i.e. that a synergistic effect is present.

TABLE-US-00010 TABLE Botrytis cinerea test (in vitro)/microtest Active compound Active compound application Known: rate in ppm % efficacy fluoxastrobin 0.003 9 ipconazole 0.003 3

[0260] Mixture According to the Invention:

TABLE-US-00011 Active compound Predicted value Mixing application rate Actual calculated using ratio in ppm efficacy Colby's formula fluoxastrobin + ipconazole } 1:1 0.003 + 0.003 } 17 12

Example 6

Pyricularia oryzae Test (In Vitro)/Microtiter Plates

[0261] The microtest is carried out in microtiter plates using potato dextrose broth (PDB) as liquid test medium. The active compounds are applied as technical-grade a.i., dissolved in acetone. For inoculation, a spore suspension Pyricularia oryzae is used. After 4 days of incubation in the dark and with shaking (10 Hrz) the light transmitted in each filled cavity of the microtiter plates is determined using a spectrophotometer.

[0262] 0% means an efficacy which corresponds to the growth in the controls, whereas an efficacy of 100% means that no fungal growth is observed.

[0263] The table below shows clearly that the activity found for the active compound combination according to the invention is greater than the calculated activity, i.e. that a synergistic effect is present.

TABLE-US-00012 TABLE Pyricularia oryzae test (in vitro)/microtest Active compound Active compound application Known: rate in ppm % efficacy fluoxastrobin 0.1 82 myclobutanil 0.1 4

[0264] Mixture According to the Invention:

TABLE-US-00013 Active compound Predicted value Mixing application rate Actual calculated using ratio in ppm efficacy Colby's formula fluoxastrobin + myclobutanil } 1:1 0.1 + 0.1 } 93 82

Example 7

Pyricularia oryzae Test (In Vitro)/Microtiter Plates

[0265] The microtest is carried out in microtiter plates using potato dextrose broth (PDB) as liquid test medium. The active compounds are applied as technical-grade a.i., dissolved in acetone in the case of fluoxastrobin and as a commercially available formulation in the case of mefenoxam (metalaxyl-M). For inoculation, a spore suspension of Pyricularia oryzae is used. After 3 days of incubation in the dark and with shaking (10 Hrz) the light transmittance in each filled cavity of the microtiter plates is determined using a spectrophotometer.

[0266] 0% means an efficacy which corresponds to the growth in the controls, whereas an efficacy of 100% means that no fungal growth is observed.

[0267] The table below shows clearly that the activity found for the active compound combination according to the invention is greater than the calculated activity, i.e. that a synergistic effect is present.

TABLE-US-00014 TABLE Pyricularia oryzae test (in vitro)/microtest Active compound Active compound application Known: rate in ppm % efficacy fluoxastrobin 0.3 84 mefenoxam 0.3 16

[0268] Mixture According to the Invention:

TABLE-US-00015 Active compound Predicted value Mixing application rate Actual calculated using ratio in ppm efficacy Colby's formula fluoxastrobin +mefenoxam } 1:1 0.3 + 0.3 } 99 87