PARALLEL MULTI-SLICE MR IMAGING WITH SUPPRESSION OF SIDE BAND ARTEFACTS

Abstract

The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). The method comprises the steps of: subjecting the object (10) to an imaging sequence comprising multi-slice RF pulses for simultaneously exciting two or more spatially separate image slices, acquiring MR signals, wherein the MR signals are received in parallel via a set of RF coils (11, 12, 13) having different spatial sensitivity profiles within the examination volume, and reconstructing a MR image for each image slice from the acquired MR signals, wherein MR signal contributions from the different image slices are separated on the basis of the spatial sensitivity profiles of the RF coils (11, 12, 13), and wherein side-band artefacts, namely MR signal contributions from regions excited by one or more side-bands of the multi-slice RF pulses, are suppressed in the reconstructed MR images on the basis of the spatial sensitivity profiles of the RF coils (11, 12, 13). Moreover, the invention relates to a MR device for carrying out this method as well as to a computer program to be run on a MR device.

Claims

1. A method of magnetic resonance (MR) imaging of an object placed in an examination volume of a MR device, the method comprising the steps of: subjecting the object to an imaging sequence comprising multi-slice RF pulses for simultaneously exciting two or more spatially separate image slices, acquiring MR signals, wherein the MR signals are received in parallel via a set of RF coils having different spatial sensitivity profiles within the examination volume, and reconstructing a MR image for each image slice from the acquired MR signals, wherein MR signal contributions from the different image slices are separated on the basis of the spatial sensitivity profiles of the RF coils, and wherein the MR signal contributions from the image slices are separated from the side-band artefacts, namely MR signal contributions from regions excited by one or more side-bands of the multi-slice RF pulses, and the separated side-band artefacts, are suppressed in the reconstructed MR images on the basis of the spatial sensitivity profiles of the RF coils.

2. The method of claim 1, wherein the MR signal contributions from the image slices are separated from the side-band artefacts without taking prior information about the excitation spectra of the multi-slice RF pulses into account.

3. The method of claim 1, wherein the MR signal contributions from the image slices are separated from the side-band artefacts by using a signal model of the acquired MR signals, which signal model comprises signal contributions from (i) the image slices and (ii) regions excited by the one or more side-bands of the multi-slice RF pulses.

4. The method of claim 3, wherein the side-band artefacts are determined by solving a set of linear equations, wherein the ratio of the signal contributions (i) and (ii) to the acquired MR signals is iteratively adjusted.

5. The method of claim 1, wherein the regions excited by the side-bands of the multi-slice RF pulses are the locations where the side-band frequencies, namely the higher order harmonics of the fundamental frequency of the multi-slice RF pulses, are in resonance in the presence of a slice-selection magnetic field gradient of the imaging sequence.

6. The method of claim 1, wherein the multi-slice RF pulses are phase-modulated, wherein the phase-modulation scheme comprises a varying phase shift, such that a phase cycle is applied to the MR signals of each image slice.

7. The method of claim 6, wherein the phase shift is linearly incremented from phase-encoding step to phase-encoding step.

8. The method of claim 1, wherein the MR signals are acquired with undersampling in the in-plane direction of the image slices, wherein the MR images are reconstructed using a parallel image reconstruction algorithm, like SENSE, SMASH or GRAPPA.

9. A magnetic resonance (MR) device for carrying out the method claimed in claim 1, wherein the MR device includes at least one main magnet coil for generating a uniform, static magnetic field within an examination volume, a number of gradient coils for generating switched magnetic field gradients in different spatial directions within the examination volume, a set of RF coils having different spatial sensitivity profiles, a control unit for controlling the temporal succession of RF pulses and switched magnetic field gradients, and a reconstruction unit, wherein the MR device is arranged to perform the following steps: subjecting the object to an imaging sequence comprising multi-slice RF pulses for simultaneously exciting two or more spatially separate image slices, acquiring MR signals, wherein the MR signals are received in parallel via a set of RF coils having different spatial sensitivity profiles within the examination volume, and reconstructing a MR image for each image slice from the acquired MR signals, wherein MR signal contributions from the different image slices are separated on the basis of the spatial sensitivity profiles of the RF coils, and the MR signal contributions from the image slices are separated from the side-band artefacts, namely MR signal contributions from regions excited by one or more side-bands of the multi-slice RF pulses, and the separate side-band artefacts, are suppressed in the reconstructed MR images on the basis of the spatial sensitivity profiles of the RF coils.

10. A computer program to be run on a magnetic resonance (MR) device, which computer program comprises instructions stored on a transitory computer readable medium for: generating an imaging sequence comprising multi-slice RF pulses for simultaneously exciting two or more spatially separate image slices, acquiring MR signals, and reconstructing a MR image for each image slice from the acquired MR signals, wherein MR signal contributions from the different image slices are separated on the basis of the spatial sensitivity profiles of a set of RF coils, and wherein the MR signal contributions from the image slices are separated from the side-band artefacts, namely MR signal contributions from regions excited by one or more side-bands of the multi-slice RF pulses, and the separated side-band artefacts, namely MR signal contributions from regions excited by one or more side-bands of the multi-slice RF pulses, are suppressed in the reconstructed MR images on the basis of the spatial sensitivity profiles of the RF coils.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The enclosed drawings disclose preferred embodiments of the present invention. It should be understood, however, that the drawings are designed for the purpose of illustration only and not as a definition of the limits of the invention. In the drawings:

[0021] FIG. 1 shows a MR device for carrying out the method of the invention;

[0022] FIG. 2a shows a MR slice image acquired using a conventional multi-slice acquisition scheme;

[0023] FIG. 2b shows a MR slice image with suppression of side-band artefacts according to the invention;

[0024] FIG. 2c shows the contribution of side-band artefacts to the MR slice image of FIG. 2a.

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] With reference to FIG. 1, a MR device 1 is shown. The device comprises superconducting or resistive main magnet coils 2 such that a substantially uniform, temporally constant main magnetic field is created along a z-axis through an examination volume.

[0026] A magnetic resonance generation and manipulation system applies a series of RF pulses and switched magnetic field gradients to invert or excite nuclear magnetic spins, induce magnetic resonance, refocus magnetic resonance, manipulate magnetic resonance, spatially and otherwise encode the magnetic resonance, saturate spins, and the like to perform MR imaging.

[0027] More specifically, a gradient pulse amplifier 3 applies current pulses to selected ones of whole-body gradient coils 4, 5 and 6 along x, y and z-axes of the examination volume. A digital RF frequency transmitter 7 transmits RF pulses or pulse packets, via a send-/receive switch 8, to a whole-body volume RF coil 9 to transmit RF pulses into the examination volume. A typical MR imaging sequence is composed of a packet of RF pulse segments of short duration which taken together with each other and any applied magnetic field gradients achieve a selected manipulation of nuclear magnetic resonance. The RF pulses are used to saturate, excite resonance, invert magnetization, refocus resonance, or manipulate resonance and select a portion of a body 10 positioned in the examination volume.

[0028] For generation of MR images of limited regions of the body 10 by means of parallel imaging, a set of local RF coils 11, 12, 13 are placed contiguous to the region selected for imaging.

[0029] The resultant MR signals are picked up by the RF coils 11, 12, 13 and demodulated by a receiver 14 preferably including a preamplifier (not shown). The receiver 14 is connected to the RF coils 9, 11, 12 and 13 via send-/receive switch 8.

[0030] A host computer 15 controls the gradient pulse amplifier 3 and the transmitter 7 to generate any of a plurality of MR imaging sequences, such as echo planar imaging (EPI), echo volume imaging, gradient and spin echo imaging, fast spin echo imaging, and the like. For the selected sequence, the receiver 14 receives a single or a plurality of MR data lines in rapid succession following each RF excitation pulse. A data acquisition system 16 performs analogue-to-digital conversion of the received signals and converts each MR data line to a digital format suitable for further processing. In modern MR devices the data acquisition system 16 is a separate computer which is specialized in acquisition of raw image data.

[0031] Ultimately, the digital raw image data is reconstructed into an image representation by a reconstruction processor 17 which applies a Fourier transform or other appropriate reconstruction algorithms. The MR image may represent a planar slice through the patient, an array of parallel planar slices, a three-dimensional volume, or the like. The image is then stored in an image memory where it may be accessed for converting slices, projections, or other portions of the image representation into appropriate format for visualization, for example via a video monitor 18 which provides a man-readable display of the resultant MR image.

[0032] With continuing reference to FIG. 1 and with further reference to FIG. 2 an embodiment of the imaging approach of the invention is explained.

[0033] According to the invention, the body 10 of the patient is subjected to an imaging sequence comprising multi-slice RF pulses by which nuclear spins within two or more spatially separate image slices are excited simultaneously. The MR signals generated by the imaging sequence are acquired in parallel via the RF coils 11, 12, 13 having different spatial sensitivity profiles. Like in conventional multi-slice techniques, a MR image is reconstructed for each image slice from the acquired MR signals, wherein the MR signal contributions from the different image slices are separated on the basis of the (known) spatial sensitivity profiles of the RF coils 11, 12, 13. The algorithm applied for separation of the image slices, which actually corresponds to the conventional SENSE unfolding algorithm, is described in more detail in the following:

[0034] At first, we consider, over the N different image slices, all image locations x.sub.i that contribute to one location x in the acquired MR signal m of each of the M receive coils. This can be written in matrix vector notation as:

Sp=m

[0035] Therein the vector m denotes the acquired MR signals m.sub.j(x) in each of the M RF coils 11, 12, 13 as a linear combination of the sensitivity-weighted signal contributions p.sub.i (x.sub.i)of the N different image slices, whereas matrix S denotes the (NM) sensitivity matrix with S.sub.ij being the coil sensitivity for coil j and slice I at position x.sub.i. Solving this system of equations including inversion of the encoding matrix yields the vector p, which contains the corresponding N slice specific MR signals:

(S.sup.HS).sup.1S.sup.Hm=p

[0036] The matrix (S.sup.HS).sup.1S.sup.H is the pseudo-inverse of S and its norm describes the error propagation from the MR signal acquisitions into the final image. This norm is small in case of a good conditioning.

[0037] According to the invention, side-band artefacts, namely MR signal contributions from regions excited by one or more side-bands of the multi-slice RF pulses, are suppressed in the reconstructed MR images on the basis of the spatial sensitivity profiles of the RF coils 11, 12, 13. In order to achieve this, a signal model is employed comprising the vector p, which contains the N slice specific main-band MR signal contributions at locations x.sub.i, and additionally a vector p, which contains L side-band MR signal contributions, i.e. MR signal contributions from regions outside the image slices that are potentially excited by the side-band frequency components of the multi-slice RF pulses. With this model, the acquired MR signals via each of the M receive coils can be written matrix as:

[00001]$S\left(\begin{array}{c}p\\ p^{}\end{array}\right)=m$

[0038] Therein matrix S denotes the (N+L)M sensitivity matrix with S.sub.ij being the coil sensitivity for coil j and main-band contributions (i=1 . . . N) and side-band contributions (i=N+1 . . . N+L). This system of equations can be solved by using the principally known regularized SENSE framework:

[00002]$\left(\begin{array}{c}p\\ p^{}\end{array}\right)=\left(S^H.Math.S+\left[\begin{array}{cc}I& 0\\ 0& {}^{-1}\end{array}\right]\left[\begin{array}{cc}{R}^{-1}& 0\\ 0& R^{-1}\end{array}\right]\left[\begin{array}{cc}I& 0\\ 0& {}^{-1}\end{array}\right]\right).Math.S^H.Math.m$

[0039] Therein R/R is the regularization matrix and a represents the ratio of the main-band and side-band contributions, with

[00003]$=\left[\begin{array}{ccc}& \mathrm{.Math.}& 0\\ \mathrm{.Math.}& & \mathrm{.Math.}\\ 0& \mathrm{.Math.}& \end{array}\right]$

[0040] The parameter can be obtained as a user parameter or it can be determined automatically by iteratively solving the above equation, wherein is updated as:

=average(p{square root over (R)})/average(p{square root over (R)})

[0041] Therein average is to be understood an average over all image voxels or over image voxels within a predetermined region around a given position. Convergence should be achieved in practice after a small number of 2-5 iterations. In a more general model, the parameter may be different for each side band, such that a parameter set .sub.1, .sub.2, . . . .sub.L could be applied. The solution of the vector p represents the N MR slice images that are free from side-band artefacts.

[0042] This is illustrated in FIG. 2. FIG. 2a shows a MR slice image reconstructed in the conventional fashion from MR signal data acquired from a phantom in parallel via a set of RF coils using multi-slice excitation. The white arrow indicates strong side-band artefacts in the centre of the MR image. FIG. 2b shows a MR slice image reconstructed from the same MR signal data using the above-described modified SENSE framework for suppressing the side-band artefacts according to the invention. As can be seen, the side-band artefacts are more or less completely eliminated in FIG. 2b. FIG. 2c shows the side-band artefacts (p) separated from the main-band signals (p) using the above framework.

[0043] In an embodiment of the invention, SENSE may be additionally applied in the in-plane phase-encoding direction using an appropriate reduction factor.