Traditional chinese medicine complex composite for significantly improving high density lipoprotein concentration in serum and preparation method thereof

Abstract

A traditional Chinese medicine complex composite for significantly improving high density lipoprotein (HDL) concentration in serum, includes: a tablet which includes 30%-50% hawthorn from north China, 10%-30% radix aucklandiae, 10%-30% radix glehniae and 10%-30% ligusticum wallichii; and a powder which includes 40%-60% beef, 15%-35% bovine sinew, 15%-35% pigskin and 0.5%-2.5% Chinese-date. The tablet is prepared by decocting and boiling the raw material medicine with water, and the powder is prepared by catalytic hydrolysis with an enzyme, the pigskin in the powder can be replaced with bovine skin or donkey skin, and the bovine sinew can be replaced with bovine tendon.

Claims

1. A combination for improving high density lipoprotein (HDL) concentration in serum, comprising: a Tiaozhong tablet and Jisheng powder; wherein the Tiaozhong tablet comprises: hawthorn from north China, radix aucklandiae, radix glehniae, and ligusticum wallichii, wherein the weight percentages of the hawthorn is 30%-50%, the radix aucklandiae is 10%-30%, the radix glehniae is 10%-30% and the ligusticum wallichii is 10%-30%; and wherein the Jisheng powder comprises: beef, bovine sinew, pigskin and Chinese-date, wherein the weight percentages of the beef is 40%-60%, the bovine sinew is 15%-35%, the pigskin is 15%-35%, and the Chinese-date is 0.5%-2.5%.

2. The combination according to claim 1, wherein weight percentages of compositions of the Tiaozhong tablet are: hawthorn from north China 35%-45%, radix aucklandiae 15%-25%, radix glehniae 15-25% and ligusticum wallichii 15%-25%; wherein the weight percentages of the Jisheng powder are: beef 45%-55%, bovine sinew 20%-30%, pigskin 20%-30% and Chinese-date 1%-2%.

3. The combination according to claim 1, wherein weight percentages of compositions of the Tiaozhong tablet are: hawthorn from north China 40%, radix aucklandiae 20%, radix glehniae 18% and ligusticum wallichii 22%; wherein the weight percentages of the Jisheng powder are: beef 50%, bovine sinew 24%, pigskin 25% and Chinese-date 1%.

4. The combination according to claim 1, wherein the pigskin in the Jisheng powder is replaced by cowhide or donkey hide.

5. The combination according to claim 1, wherein the bovine sinew is obtained from cow hoof.

6. A method for treating a heart disease or a cerebrovascular disease which is caused by atherosclerosis in a subject in need thereof comprising administering to the subject an effective amount of the combination according to claim 1.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

(1) Further description of the present invention is illustrated combined with the preferred embodiments.

(2) A traditional Chinese medicine complex composite of the present invention comprises Tiaozhong tablet and Jisheng powder.

(3) I. Tiaozhong Tablet

Example 1

(4) Weigh 5 kilograms of hawthorn from north China, 1.8 kilograms of radix aucklandiae, 1.6 kilograms of radix glehniae and 1.6 kilograms of ligusticum wallichii, set aside.

(5) A preparing method of the Tiaozhong tablet comprises steps of: selecting and mixing four components of the Tiaozhong tablet, flushing with water, weighing out one tenth of total weight of the Tiaozhong tablet for drying and smashing to obtain dry powder, and then processing according to conventional Chinese pharmaceutical manufacturing technology comprising steps of: soaking the four components of the Tiaozhong tablet which is not selected, decocting with water, filtering, concentrating, adding all of the dry powder mentioned above, initially forming solid medicine, drying, crushing to produce powder, and preparing tablets. Each tablet has a weight of 0.3-0.4 g.

(6) Usage: Take orally, 4-6 tablets each time, twice a day.

(7) Preferably, the tablets can also be made into powder, pills or capsule.

Example 2

(8) Weigh 3.5 kilograms of hawthorn from north China, 2.5 kilograms of radix aucklandiae, 1.6 kilograms of radix glehniae and 2.4 kilograms of ligusticum wallichii, set aside.

(9) Preparation and usage methods of this example are identical with those of the example 1.

Example 3

(10) Weigh 4 kilograms of hawthorn from north China, 2 kilograms of radix aucklandiae, 1.8 kilograms of radix glehniae and 2.2 kilograms of ligusticum wallichii, set aside.

(11) Preparation and usage methods of this example are identical with those of the example 1.

(12) II. Jisheng Powder

Example 1

(13) Weigh 6 kilograms of beef, 1.5 kilograms of bovine sinew, 2.3 kilograms of pig skin, 0.2 kilogram of Chinese-date, set aside.

(14) A preparing method of the Jisheng powder comprises: selecting the beef, the bovine sinew, the pigskin and the Chinese-date, washing with water, cutting the beef, the bovine sinew and the pigskin into pieces or strips, boiling for 10-15 min, levigating, feeding water to blend into appropriate paste, then processing by a enzyme catalyzed hydrolysis technology, wherein a process of the enzyme catalyzed hydrolysis technology comprises steps of: adding papain to the paste, processing hydrolysis reaction under 60 C. for 12 hours, boiling 15 min to destroy enzyme, performing high speed centrifugation to degrease, deslagging, filtering to obtain animal protein hydrolysate in a liquid state, concentrating, spray drying, packaging to obtain powder products. Each package has a weigh of 10-15 g.

(15) Usage: Take orally, for an adult, 1 package each time, three times a day. The Jisheng powder can be taken with meals.

Example 2

(16) Weigh 4.5 kilograms of beef, 2.35 kilograms of bovine sinew, 3 kilograms of pig skin, 0.15 kilogram of Chinese-date, set aside.

(17) Preparation and usage methods in this example are identical with those in the example 1.

Example 3

(18) Weigh 5 kilograms of beef, 2.4 kilograms of bovine sinew, 2.5 kilograms of pig skin, 0.1 kilogram of Chinese-date, set aside.

(19) Preparation and usage method is identical with the example 1.

(20) While using, the tablets, powder, pills or capsule obtained in the three examples is combined randomly with powdery products obtained in the three examples of Jisheng powder.

(21) The traditional Chinese medicine complex composite: Tiaozhong tablets and Jisheng powder are capable of significantly improving high density lipoprotein (HDL) concentration in serum, have better effects than western medicine of niacin and statin, and thus is a traditional inartificial Chinese medicine having great potential value.

INDUSTRIAL APPLICABILITY

(22) The Jisheng powder of the present invention contains various kinds of amino acids, which is the main substance for constituting various immune cells, antibodies and complements and the like in the human body. Only when the kinds and the amount of the amino acids are sufficient, can the human body synthesizing various kinds of immune cells, antibodies, complements and etc. The Jisheng powder of the present invention significantly improves the immunity of the human body to keep the immune system healthy and strong, in such a manner that most of the diseases of the human body including reduction of the HDL level of the serum are expected to be cured. In addition, according to the principle of biochemistry, when the human body utilizes amino acids and other substances to synthesize HDL, under the condition of unchanged enzyme concentration and other conditions, improving the concentration of the substrate amino is capable of improving the synthesis speed of HDL. On the condition of having sufficient amino acids, the increase of the product HDL is capable of increasing the HDL concentration in serum. The Jisheng powder is capable of high efficiently and sufficiently providing the required amino acids for synthesizing HDL, which is the substance for significantly improving HDL concentration in serum.

(23) Apparently, the Tiaozhong tablets and the Jisheng powder of the present invention are combined together for application, so as to treat both manifestation and root cause of disease to fully develop the effect of significantly improving HDL concentration in serum.

(24) In a small sample of an experiment lasted for 6 years for utilizing the present invention to improve HDL concentration. The average value of HDL concentration at the beginning of the testee is a base line. After applying the medicine of the present invention for 1 to 6 years, the HDL concentration in serum of the testee has maximum increasing magnitude of 92.6%, and a minimum increasing magnitude of 43.9%. During the 6 years, the median of the HDL in serum has improved for 65.6% than the base line, no apparent side effects and no exception in the liver and kidney. The experiment confirms that the present invention is capable of significantly improving HDL concentration in serum, and the effects thereof are better than the medicine of niacin and statins.

(25) Apparently, the present invention is capable of significantly improving HDL concentration in serum, without apparent side effects and can be applied in long time. Though the medicine of the present invention has slow onset of at least three months, the effects thereof is steady and permanent. In addition, the medicine of the present invention can be applied combining with a statin drug, so as to combine treating and cultivating, and the application thereof is convenient. The medicine of the present invention is natural and has great potential value and expected to be essential drugs for treating cardiovascular and cerebrovascular diseases.