MULTIMODALITY ID MARKERS FOR DELINEATING THE POSITION OF A REGION OF INTEREST (ROI) WITHIN A BODY

Abstract

Multimodality markers for delineation of a region of interest (ROI) within a patient's body are disclosed. The markers may comprise a hermetic bio-compatible container and an external element that is associated with the hermetic bio-compatible container. A unique collective identification (ID) is assigned to each of the markers. The collective ID can comprise a visible component seen on an imaging system and an electronic component stored in a microelectronic chip and embedded within the hermetic bio-compatible container.

Claims

1. One or more markers for delineation of a region of interest (ROI) within a patient's body: wherein each marker from the one or more markers is associated with a unique collective identification (ID) which differentiates it from another marker wherein the unique collective ID is represented by at least two features; and wherein at least one feature from the at least two features is represented by a visualized ID (VID) feature, which is configured to be visualized by an imaging system.

2. The one or more markers of claim 1, wherein the VID feature comprises unique radio opaque marking.

3. The one or more markers of claim 1, wherein the VID feature comprises unique ridges on the markers surface.

4. The one or more markers of claim 1, wherein the VID feature comprises unique interspaced gaps in a radio opaque coil windings.

5. The one or more markers of claim 1, wherein the VID feature comprises a unique shape of its antenna.

6. The one or more markers of claim 1, wherein the VID feature comprises an external-identification-element (EIE).

7. The one or more markers of claim 1, wherein the VID feature comprises one or more clips attached to the marker.

8. The one or more markers of claim 1, wherein the VID feature comprises one or more rings attached to the marker.

9. The one or more markers of claim 1, wherein each marker comprises a microelectronic chip.

10. The one or more markers of claim 9, wherein the microelectronic chip stores an electronic representation of the unique ID of that marker.

11. The one or more markers of claim 1, wherein the imaging system comprises an X-Ray system.

12. The one or more markers of claim 1, wherein the unique VID of each marker is identified by an ultrasound system.

13. The one or more markers of claim 12, wherein the marker is coated by a unique ultrasound enhancing material.

14. The one or more markers of claim 13, wherein the ultrasound material is hydrophilic material.

15. The one or more markers of claim 1, wherein at least two markers are joined together into a joint-marker.

16. The joint-marker of claim 15, wherein each marker of the joined-marker is uniquely identifiable by a VID feature.

17. The joint-marker of claim 15, wherein the joined-marker is uniquely identifiable by the shape of the connection between the at least two markers.

18. The markers of claim 15, wherein the unique ID of each marker is identified by a unique shape of its one or more attached EIE.

19. A marker for delineation of a region of interest (ROI) within a patient's body comprising: i. a hermetic bio-compatible container; and ii. an element that is associated with the hermetic bio-compatible container; and wherein the marker is associated with a unique collective identification (ID).

20. The marker of claim 19, wherein the hermetic bio-compatible container is made of bio-compatible dielectric material.

21. The marker of claim 20, wherein the bio-compatible dielectric material is plastic.

22. The marker of claim 19, wherein the hermetic bio-compatible container comprising: i. a microelectronic chip; and ii. a dipole antenna wherein the element that is associated with the hermetic bio-compatible container is a pole of the dipole antenna.

23. The marker of claim 19, further comprising an electromagnetic antenna.

24. The marker of claim 19, wherein the unique collective ID is visualized by an imaging system.

25. The marker of claim 24, wherein the unique collective ID comprises an external-identification-element (EIE).

26. The marker of claim 22, wherein the microelectronic chip stores an electronic representation of the unique collective ID.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Example embodiments of the present disclosure will be understood and appreciated more fully from the following detailed description, taken in conjunction with the drawings in which:

[0025] FIG. 1 schematically illustrates examples of different mechanical assemblies of markers;

[0026] FIG. 2 schematically illustrates examples of markers with different configurations and shapes of antennae and/or EIE's.

DETAILED DESCRIPTION OF SOME EXAMPLE EMBODIMENTS

[0027] Turning now to the figures in which like numerals represent like elements throughout the several views, in which exemplary embodiments of the disclosed techniques are described. For convenience, only some elements of the same group may be labeled with numerals.

[0028] The purpose of the drawings is to describe examples of embodiments and not for production purpose. Therefore, features shown in the figures are chosen for convenience and clarity of presentation only and are not necessarily shown to scale. Moreover, the language used in this disclosure has been principally selected for readability and instructional purposes, and may not have been selected to define or limit the inventive subject matter.

[0029] In this specification, these implementations, or any other form that the invention may take, may be referred to as techniques. In general, the order of the steps of disclosed processes may be altered within the scope of the invention. Reference in the specification to “one embodiment” or to “an embodiment” means that a particular feature, structure, or characteristic described in connection with the embodiments is included in at least one embodiment of the invention, and multiple references to “one embodiment” or “an embodiment” should not be understood as necessarily all referring to the same embodiment.

[0030] In the following description, the words “unit,” “element,” “module”, and “logical module” may be used interchangeably. Anything designated as a unit or module may be a stand-alone unit or a specialized or integrated module. A unit or a module may be modular or have modular aspects allowing it to be easily removed and replaced with another similar unit or module. Each unit or module may be any one of, or any combination of, hardware configured to execute the task ascribed to the unit or module. In the present disclosure the terms task, method, and process can be used interchangeably. In addition, the terms element and section can be used interchangeably.

[0031] FIG. 1 schematically illustrates relevant elements of examples of different mechanical assemblies of markers. An example of marker 100 may comprise a microelectronic chip 109, a dipole antenna 106a and 106b, an electromagnetic antenna 108, a hermetic bio-compatible container 102, and unique visual ID symbols (VID) 104. Examples of hermetic bio-compatible container 102 can be made of bio-compatible dielectric material, such as but not limited to glass and/or plastic. In some examples of marker 100, element 106a may not serve as antenna but is used as an EIE, which is attached to the hermetic bio-compatible container 102. In such embodiment, element 106a is not electrically connected to the microelectronic chip 109. Yet, in some embodiments of a marker 100, the antenna and the EIE can be simultaneously attached to the body of the marker 102.

[0032] In some embodiments of marker 100 the VID of the marker/s can be designated by varying uniquely identifiable radio opaque identification markings 104. Markings 104 can be such as but not limited to shapes, letters or numbers on or within the receptacle capsule of the marker. In some embodiments of marker 100 the VID of the marker/s can be designated by unique ridges on the markers surface, unique interspaced gaps in the markers metallic coil windings and attached rings and clips (not shown) for example. In some embodiments of marker 100 the VID of the marker/s can be designated by varying the physical appearance or geometric bended shape of the marker and or the shape of an element, which can be an external antenna and/or an EIE, which are attached to the container 102. Both the above types being visible with imaging modalities such as but not limited to X-Ray and mammography. Further, a part of the unique collective ID of the marker 100 can be a unique electronic ID that is stored in the microelectronic chip 109. The VID of each marker can be established by at least one feature from a group of features including for example; radio opaque markings, antennae shape, the shape of an attached external-identification-element (EIE), unique ridges on the markers surface, unique interspaced gaps in the markers metallic coil windings and attached rings and clips.

[0033] Furthermore, the VID of the markers can be correlated with their electronic identification. For example, a specific marker visualized on a mammogram X-Ray can be identified by the unique radio opaque markings 104 of its encasement and by the unique shape of its external antenna and or its EIE as well as by its unique electronic ID that was stored in the microelectronic chip 109 prior to its placement in the body tissue. All the forms of ID designation of each marker can be correlated and combined so as to characterize each marker's unique collective ID.

[0034] The identifying features described above are also applicable to other marker designs that can be detected by a plurality of signals (i.e, with multimodality systems). For example, some example embodiments may comprise a receptacle capsule (not shown in the figures) without any external antenna but with one or more attached EIEs. Other example embodiments of a marker may comprise a capsule 102 and one or more external antenna. Other embodiments of a marker may comprise reflective material such as but not limited to metal or combination of metals with attached external EIE/s. Further example embodiments of a marker may embody a unique electronic ID being neither in the form of a capsule or a pellet. Such embodiment can be associated with an electronic card that stores the unique electronic ID of the marker. Such embodiment can be associated with an EIE. Any combination of the above methods can be used to characterizing the unique collective ID of markers of multiple designs detected by a plurality of signals. Markers with different unique collective ID's may be combined to constitute a system of markers.

[0035] The VID of each marker can be established for example as follows. In the case of markers with a receptacle capsule or electronic card, the above described uniquely identifying radio opaque markings 104 would be applicable. In cases where antenna/e 106a and or EIE are present, the physical appearance or geometric bended shape of the marker and or the external antenna 106a and or the EIE attached to the marker would be applicable. In the case of the marker being comprised of a reflective material with attached EIE, the physical appearance or geometric bended shape of the marker and or the EIEs attached to the marker would be applicable in designating the visible identity of the marker. Combinations of the above described markers and identifying features may be applicable too.

[0036] When a single marker has been placed in a body of tissue, for example in a breast, and delineates an ROI, the confirmation of removal of the marker is established by performing an X-Ray of the excised surgical specimen. This may be done in the operating room. The operator may also use a hand held detector, scan over the specimen and with a locator system confirm the presence of the marker within it.

[0037] However, there are instances where multiple markers are used to delineate the ROI. Furthermore, there can be instances where additional markers unrelated to the ROI and not requiring surgical excision may be present in one breast, for example. The medical records should contain the information of each markers placed position and corresponding electronic ID. However, when multiple markers with a like appearance at imaging system are reviewed, it can be extremely challenging to accurately correlate each marker as seen on the mammogram with its own recorded electronic ID. This problem is compounded when there is evidence of marker migration and the specific marker needs to be identified on the mammogram. Successful removal of a marker is not an automatic confirmation of removal of the ROI.

[0038] For example, three markers, each with a registered unique electronic ID may be cited in the records as being placed at 2 o'clock in the left breast. The recorded data is often insufficient for the operator to be quite sure as to which of the three markers the three registered electronic IDs belong. They are all at 2 o'clock and they all look alike or almost alike on the mammogram. In such a setting, a plurality of marker features identifiable on mammography can be extremely helpful. Since the three markers at 2 o clock may now have different unique encasement and/or antenna and/or EIE features, and since they can be visually uniquely differentiated one from the other, and since their correlating unique electronic ID's are known, the operator is more empowered to establish which markers are related to the ROI and require excision and which can be left in place. The operator can more comprehensively plan the surgical procedure.

[0039] Following the localization and removal of the markers and presumably the associated ROI, the surgical specimen can be X-rayed and scanned with a hand-held locator. In this instance, apart from the electronic ID's established by the locator, the X-Ray will confirm to the surgeon that the desired marker/s from the 2 o'clock area of the left breast has/have been removed. This is established by comparing the visible ID features of the markers in the specimen X-Ray with the visible marker features on the pre-operative mammogram. This is especially helpful in the event of the locator and the localization system failing at surgery to locate the marker/s.

[0040] The visible ID's also allow for the identification and follow up of non-palpable lesions which having undergone image guided biopsies and marked at the time of biopsy and are only subsequently found to be benign and not requiring excision. These lesions can then be uniquely identified for example at mammography and hence with confidence identified for targeted follow up.

[0041] For example, the visual ID of the presented marker 100 is comprised by three dots/circles 104 made of radio opaque material, as well as by the shape of the radio opaque external antenna 106a which in this illustration is in the form of a spring. The material comprising the radio opaque markings may be silver or tungsten, for example. The external antenna and or the attached EIE/s (not shown) may be of tungsten or nitinol or a combination of appropriate metals. For example, the material can be a memory metal.

[0042] An example group 101 demonstrates several markers in which the external antenna or the attached EIE has a unique shape. The unique shape can represent part of the unique collective ID that was allocated to that marker. The external antenna or the attached EIE can be made of metal that can be visible by imaging devices such as but not limited to X-Ray, CT, ultra-sound (US), etc. The metal can be tungsten or nitinol, for example. In some embodiments the external antenna with its unique shape may be an external pole 106a of a dipole antenna 106a & 106b. In other embodiments, one or more external antenna with unique shapes may be part of a marker that is configured to be located with an infra-red signal.

[0043] The example group 101 illustrates marker encasements with various numbers of radio opaque markings 104, in this case dots and or circles, which by way of their number/configuration further characterize the visual ID of the markers, for example. The markers' unique electronic ID is stored in the microelectronic chip 109. The external antenna and or the attached EIE can be made of metal that can be visible by imaging devices such as but not limited to X-Ray, CT, ultra-sound (US), etc. The radio opaque encasement markings 104 are also applicable in the case of joined markers. The connection between joined markers can also be uniquely formed and identifiable. The markers (a single or a joint marker) may be comprised of either or both external antenna/e and attached EIE/s, each with unique identifying shapes visible on imaging systems.

[0044] Another example group 120 demonstrates pairs of joined-markers. The joined-markers 120 are self-anchored by an expandable, retractable direct spring 122 or by an expandable retractable pre-bent spring 124. The spring can be made of bio-compatible diamagnetic metal, nitinol or tungsten for example. In some embodiments the spring 122 or 124 may serve as an external part of the antenna of its associated pair of markers. For example, as part of the dipole of a dual-frequency antenna.

[0045] A third group 130 demonstrates other pairs of joined-markers. The joined-markers 130 are self-anchored by a fixed direct spring 132 or a fixed pre-bent spring 134. The fixed spring can be made of bio-compatible diamagnetic metal, nitinol or tungsten for example. In some embodiments the fixed direct spring 132 or the fixed pre-bend spring 134 may serve as an external part of a dual-frequency antenna of its associated pair of markers.

[0046] The connection of markers with fixed, expandable, retractable, direct and pre-bent springs (being antenna/e and or EIE/s) as described above would be applicable to all forms and combinations of markers such as but not limited to markers comprised of a capsule, markers comprised of a reflective material which can be a metal or combination of metals and markers comprised of a card with a unique ID.

[0047] FIG. 2 illustrates example embodiments of makers comprising folding dipole antennae. Such example embodiments may comprise a capsule 202 or 202a associated with two folding arms 203 and 204 and 203a and 204a (respectively) of a dipole antenna. Wherein the marker is configured to be situated within the lumen of a needle 201 and can be deployed from the needle 201. The antennae are designed to assume varying angles of orientation to each other on deployment from the needle 201. The two arms 203 and 204 are configured to be opened at an angle of 120 degrees to each other, for example; while arms 203a and 204a are configured to open at an angle of 180 degrees to each other, for example. In some embodiments of the disclosed technique the marker's antennae and attached EIE's can be of differing configurations and shapes. The antennae can be in the form of a spring 207, and the EIE's can be in the form of a hook 205 or a spring 206, for example.

[0048] The markers that are illustrated in FIG. 2 can be made of materials similar to the materials that are disclosed above in conjunction with FIG. 1. In addition, the markers that are related to FIG. 2 may comprise identification elements similar to the identification elements of the markers that are disclosed above in conjunction with FIG. 1. Further, the markers related to FIG. 2 can be configured to be associated as joined-markers as it is disclosed above. In the present disclosure and the claims, the terms joint-markers, joint marker, joined markers, joined-markers, and joined-marker may be used interchangeably.

[0049] In the description and claims of the present disclosure, each of the verbs, “comprise”, “include”, “have”, and conjugates thereof, are used to indicate that the object or objects of the verb are not necessarily a complete listing of members, components, elements, or parts of the subject or subjects of the verb.

[0050] The present disclosure has been described using detailed descriptions of embodiments thereof that are provided by way of example and are not intended to limit the scope of the invention. The described embodiments comprise different features, not all of which are required in all embodiments of the invention. Some embodiments of the present invention utilize only some of the features or possible combinations of the features. Many other ramification and variations are possible within the teaching of the embodiments comprising different combinations of features noted in the described embodiments.

[0051] It will be appreciated by persons skilled in the art that the present invention is not limited by what has been particularly shown and described herein above. Rather the scope of the invention is defined by the claims that follow.