SUBSTITUTED CYANO CYCLOALKYL PENTA-2,4-DIENES, CYANO CYCLOALKYL PENT-2-EN-4-YNES, CYANO HETEROCYCLYL PENTA-2,4-DIENES AND CYANO HETEROCYCLYL PENT-2-EN-4-YNES AS ACTIVE SUBSTANCES

Abstract

The invention relates to cyano cycloalkyl penta-2,4-dienes, cyano cycloalkyl pent-2-en-4-ynes, cyano heterocyclyl penta-2,4-dienes and cyano heterocyclyl pent-2-en-4-ynes of general formula (I), or the salts thereof, where [X-Y], Q, R.sup.1, R.sup.2, A.sup.1, A.sup.2, V, W, m and n have the definitions specified in the description. The invention also relates to a production method for same and to the use of same for increasing stress tolerance in plants against abiotic stress, and/or for increasing the plant yield.

##STR00001##

Claims

1. Cyanocycloalkylpenta-2,4-dienes, cyanocycloalkylpent-2-en-4-ynes, cyanoheterocyclylpenta-2,4-dienes and cyanoheterocyclylpent-2-en-4-ynes of the general formula (I) or salts thereof ##STR00612## where [X-Y] represents the moieties ##STR00613## Q represents the moieties ##STR00614## where R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are each as defined below and where the arrow represents a bond to the respective [X-Y] moiety; R.sup.1 is hydrogen, alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkenyl, alkynyl, alkynylalkyl, alkoxyalkyl, hydroxyalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl, alkylthioalkyl, arylalkyl, heterocyclylalkyl, halocycloalkyl, cycloalkenyl, alkoxyalkoxyalkyl, cycloalkylalkyl, cycloalkenylalkyl, haloalkynyl, alkylsulphinylalkyl, alkylsulphonylalkyl, halocycloalkylalkyl, cycloalkylsulphinylalkyl, cycloalkylsulphonylalkyl, arylsulphinylalkyl, arylsulphonylalkyl, arylthioalkyl, cycloalkylthioalkyl, alkoxyhaloalkyl, haloalkoxyhaloalkyl, R.sup.2 is hydrogen, alkyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkenyl, alkynyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, alkenylcarbonyl, heterocyclylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, aryloxyalkyl, arylalkoxycarbonyl, cycloalkoxycarbonyl, cycloalkylalkoxycarbonyl, arylalkoxyalkyl, arylalkyl, alkoxyalkoxyalkyl, alkylthioalkyl, trialkylsilyl, alkyl(bisalkyl)silyl, alkyl(bisaryl)silyl, aryl(bisalkyl)silyl, cycloalkyl(bisalkyl)silyl, halo(bisalkyl)silyl, trialkylsilylalkoxyalkyl, trialkylsilylalkyl, alkynyloxycarbonyl, cycloalkyl, cycloalkylalkyl, aminocarbonyl, alkylaminocarbonyl, bisalkylaminocarbonyl, cycloalkylaminocarbonyl, alkylsulphonyl, haloalkylsulphonyl, arylsulphonyl, heteroarylsulphonyl, cycloalkylsulphonyl, A.sup.1, A.sup.2, V, W are each independently a CR.sup.3R.sup.4 group, oxygen or sulphur, where not more than 2 oxygen or 2 sulphur atoms are present in the ring formed by the A.sup.1, A.sup.2, V, W groups and the carbon atom to which they are bonded, and where the oxygen and sulphur atoms are not adjacent to one another, m is 0, 1, 2, n is 0, 1, 2, R.sup.3 and R.sup.4 are each independently hydrogen, alkyl, halogen, cycloalkyl, alkoxy, aryl, heterocyclyl, heteroaryl, arylalkyl, alkylthio, haloalkyl, haloalkyloxy, haloalkylthio, alkoxyalkyl, alkylthioalkyl, heteroarylalkyl, heterocyclylalkyl, cycloalkylalkyl, cycloalkenyl, alkynyl, alkenyl, haloalkenyl, haloalkynyl, alkylsulphinyl, alkylsulphonyl, cycloalkylsulphinyl, cycloalkylsulphonyl, arylsulphinyl, arylsulphonyl, alkoxyhaloalkyl, haloalkoxyhaloalkyl, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.5 and R.sup.6 are each independently hydrogen, halogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, R.sup.7 is hydrogen, halogen, alkyl, haloalkyl, haloalkoxy, haloalkoxyalkyl, haloalkoxyhaloalkyl, alkoxyhaloalkyl, alkynyloxyhaloalkyl, alkenyloxyhaloalkyl, alkylthio, haloalkylthio, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, alkoxy, hydroxyl, alkylcarbonyloxy, arylcarbonyloxy, cycloalkylcarbonyloxy, trisalkylsilyloxy, bisalkyl(alkyl)silyloxy, alkyl(bisaryl)silyloxy, aryl(bisalkyl)silyloxy, cycloalkyl(bisalkyl)silyloxy, halo(bisalkyl)silyloxy, trialkylsilylalkoxyalkyloxy, trialkylsilylalkyloxy, alkylsulphinyl, alkylsulphonyl, cycloalkylsulphinyl, cycloalkylsulphonyl, arylsulphinyl, arylsulphonyl, cycloalkyl, cycloalkylalkyl, R.sup.6 and R.sup.7 together with the atoms to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.8 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroarylalkyl, bisarylalkyl, trisarylalkyl, alkenyl, cycloalkenylalkyl, alkynylalkyl, trialkylsilylalkoxyalkyl, alkoxyalkoxyalkyl, alkylthioalkyl, haloalkyl, arylsulphonylalkyl, trialkylsilyl, alkyl(bisaryl)silyl, alkyl(bisalkyl)silyl, bisalkylaminoalkyl, heterocyclylalkyl, alkynyl, cyanoalkyl, heterocyclyl, cycloalkenyl, R.sup.9 is hydrogen, alkyl, cycloalkyl, halogen, alkynylalkyl, haloalkyl, alkynyl, alkenyl, cyanoalkyl, cycloalkylalkyl, arylalkyl, heteroarylalkyl, alkylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkenylalkyloxycarbonyl, arylalkyloxycarbonyl, cycloalkoxycarbonyl, cycloalkylalkoxycarbonyl, alkylsulphonyl, arylsulphonyl, cycloalkylsulphonyl, alkylsulphinyl, arylsulphinyl, cycloalkylsulphinyl, alkoxycarbonylalkyl, hydroxycarbonylalkyl, arylalkoxycarbonylalkyl, cycloalkylalkoxycarbonylalkyl, alkoxycarbonylcycloalkyl, hydroxycarbonylcycloalkyl, arylalkoxycarbonylcycloalkyl, alkenyloxycarbonylcycloalkyl, aminocarbonylcycloalkyl, alkylaminocarbonylcycloalkyl, cycloalkylaminocarbonylcycloalkyl, alkoxycarbonylcycloalkenyl, hydroxycarbonylcycloalkenyl, bisalkylaminoalkyl, hydroxycarbonylheterocyclyl, alkoxycarbonylheterocyclyl, alkenyloxycarbonylheterocyclyl, alkenylalkoxycarbonylheterocyclyl, arylalkoxycarbonylheterocyclyl, cycloalkoxycarbonylheterocyclyl, cycloalkylalkoxycarbonylheterocyclyl, aminocarbonylheterocyclyl, alkylaminocarbonylheterocyclyl, bisalkylaminocarbonylheterocyclyl, cycloalkylaminocarbonylheterocyclyl, arylalkylaminocarbonylheterocyclyl, alkenylaminocarbonylheterocyclyl, hydroxycarbonylheterocyclylalkyl, alkoxycarbonylheterocyclylalkyl, hydroxycarbonylcycloalkylalkyl, alkoxycarbonylcycloalkylalkyl, hydroxyl, alkoxy, heterocyclyl, heterocyclylalkyl, aryl, cycloalkenyl, cycloalkenylalkyl, R.sup.10 is hydrogen, alkyl, cycloalkyl, halogen, haloalkyl, alkynyl, alkenyl, cyanoalkyl, arylalkyl, heteroarylalkyl, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, arylsulphonyl, cycloalkylsulphonyl, alkylsulphinyl, arylsulphinyl, cycloalkylsulphinyl, alkoxycarbonylalkyl or R.sup.9 and R.sup.10 with the nitrogen to which they are attached form an optionally halogen-, alkyl-, haloalkyl-, alkoxy-, alkoxycarbonyl-, cycloalkoxycarbonyl-, cycloalkylalkoxycarbonyl-, alkenyloxycarbonyl-, hydroxycarbonyl-, aminocarbonyl-, alkylaminocarbonyl-, cycloalkylaminocarbonyl-, arylalkylaminocarbonyl-substituted three- to eight-membered ring which is optionally interrupted by O, S or N or R.sup.9 and R.sup.10 together are part of an optionally substituted sulphilimine or amidine group or form an iminophosphorane and R.sup.11 is hydrogen, alkyl, cycloalkyl, haloalkyl, alkoxyalkyl, alkylthioalkyl.

2. Cyanocycloalkylpenta-2,4-dienes, cyanocycloalkylpent-2-en-4-ynes, cyanoheterocyclylpenta-2,4-dienes and cyanoheterocyclylpent-2-en-4-ynes according to claim 1, where [X-Y] represents the moieties ##STR00615## Q represents the moieties ##STR00616## where R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are each as defined below and where the arrow represents a bond to the respective [X-Y] moiety, R.sup.1 is hydrogen, (C.sub.1-C.sub.8)-alkyl, aryl, heteroaryl, heterocyclyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkynyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, hydroxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-halocycloalkyl, (C.sub.4-C.sub.8)-cycloalkenyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-halocycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, arylsulphinyl-(C.sub.1-C.sub.8)-alkyl, arylsulphonyl-(C.sub.1-C.sub.8)-alkyl, arylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, R.sup.2 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.2-C.sub.8)-alkenylcarbonyl, heterocyclylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl, aryloxy-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.1-C.sub.8)-alkylbis[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.1-C.sub.8)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.3-C.sub.8)-cycloalkylbis[(C.sub.1-C.sub.8)-alkyl]silyl, halobis[(C.sub.1-C.sub.8)-alkyl]silyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkynyloxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, aminocarbonyl, (C.sub.1-C.sub.8)-alkylaminocarbonyl, bis[(C.sub.1-C.sub.8)-alkyl]aminocarbonyl, (C.sub.3-C.sub.8)-cycloalkylaminocarbonyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, arylsulphonyl, heteroarylsulphonyl, (C.sub.3-C.sub.8)-cycloalkylsulphonyl, A.sup.1, A.sup.2, V, W are each independently a CR.sup.3R.sup.4 group, oxygen or sulphur, where not more than 2 oxygen or 2 sulphur atoms are present in the ring formed by the A.sup.1, A.sup.2, V, W groups and the carbon atom to which they are bonded, and where the oxygen and sulphur atoms are not adjacent to one another, m is 0, 1, 2, n is 0, 1, 2, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1-C.sub.8)-alkyl, halogen, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.1-C.sub.8)-alkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkyloxy, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkenyl, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.5 and R.sup.6 are each independently hydrogen, halogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, R.sup.7 is hydrogen, halogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkynyloxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkenyloxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-haloalkylthio, optionally substituted phenyl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, (C.sub.1-C.sub.8)-alkoxy, hydroxyl, (C.sub.1-C.sub.8)-alkylcarbonyloxy, arylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkylcarbonyloxy, tris[(C.sub.1-C.sub.8)-alkyl]silyloxy, bis[(C.sub.1-C.sub.8)-alkyl]-[(C.sub.1-C.sub.8)-alkyl]silyloxy, (C.sub.1-C.sub.8)-alkylbisarylsilyloxy, arylbis[(C.sub.1-C.sub.8)-alkyl]silyloxy, (C.sub.3-C.sub.8)-cycloalkylbis[(C.sub.1-C.sub.8)-alkyl]silyloxy, halobis[(C.sub.1-C.sub.8)-alkyl]silyloxy, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyloxy, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkyloxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, R.sup.6 and R.sup.7 together with the atoms to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.8 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, optionally substituted phenyl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, bisaryl-(C.sub.1-C.sub.8)-alkyl, trisaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.4-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkynyl-(C.sub.1-C.sub.8)-alkyl, tri-(C.sub.1-C.sub.8)-alkylsilyl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, arylsulphonyl-(C.sub.1-C.sub.8)-alkyl, tri-(C.sub.1-C.sub.8)-alkylsilyl, (C.sub.1-C.sub.8)-alkyl(bisaryl)silyl, (C.sub.1-C.sub.8)-alkyl(bis-(C.sub.1-C.sub.8)-alkyl)silyl, bis(C.sub.1-C.sub.8)-alkylamino-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkynyl, cyano-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, optionally further-substituted phenyl, R.sup.9 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, halogen, (C.sub.2-C.sub.8)-alkynyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkenyl, cyano-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl, (C.sub.2-C.sub.8)-alkenyl-(C.sub.1-C.sub.8)-alkyloxycarbonyl, aryl-(C.sub.1-C.sub.8)-alkyloxycarbonyl, (C.sub.3-C.sub.8)-cycloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-alkylsulphonyl, arylsulphonyl, (C.sub.3-C.sub.8)-cycloalkylsulphonyl, (C.sub.1-C.sub.8)-alkylsulphinyl, arylsulphinyl, (C.sub.3-C.sub.8)-cycloalkylsulphinyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.3-C.sub.8)-cycloalkyl, hydroxycarbonyl-(C.sub.3-C.sub.8)-cycloalkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.3-C.sub.8)-cycloalkyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl-(C.sub.3-C.sub.8)-cycloalkyl, aminocarbonyl-(C.sub.3-C.sub.8)-cycloalkyl, (C.sub.1-C.sub.8)-alkylaminocarbonyl-(C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkylaminocarbonyl-(C.sub.3-C.sub.8)-cycloalkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.4-C.sub.8)-cycloalkenyl, hydroxycarbonyl-(C.sub.4-C.sub.8)-cycloalkenyl, bis-(C.sub.1-C.sub.8)-alkylamino-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonylheterocyclyl, (C.sub.1-C.sub.8)-alkoxycarbonylheterocyclyl, (C.sub.2-C.sub.8)-alkenyloxycarbonylheterocyclyl, (C.sub.2-C.sub.8)-alkenyl-(C.sub.1-C.sub.8)-alkoxycarbonylheterocyclyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonylheterocyclyl, (C.sub.3-C.sub.8)-cycloalkoxycarbonylheterocyclyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxycarbonylheterocyclyl, aminocarbonylheterocyclyl, (C.sub.1-C.sub.8)-alkylaminocarbonylheterocyclyl, bis-(C.sub.1-C.sub.8)-alkylaminocarbonylheterocyclyl, (C.sub.3-C.sub.8)-cycloalkylaminocarbonylheterocyclyl, aryl-(C.sub.1-C.sub.8)-alkylaminocarbonylheterocyclyl, (C.sub.2-C.sub.8)-alkenylaminocarbonylheterocyclyl, hydroxycarbonylheterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonylheterocyclyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, hydroxyl, (C.sub.1-C.sub.8)-alkoxy, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, optionally substituted phenyl, R.sup.10 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, halogen, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkenyl, cyano-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-alkylsulphonyl, arylsulphonyl, (C.sub.3-C.sub.8)-cycloalkylsulphonyl, (C.sub.1-C.sub.8)-alkylsulphinyl, arylsulphinyl, (C.sub.3-C.sub.8)-cycloalkylsulphinyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.9 and R.sup.10 together with the nitrogen to which they are bonded form an optionally halogen-, (C.sub.1-C.sub.8)-alkyl-, (C.sub.1-C.sub.8)-haloalkyl-, (C.sub.1-C.sub.8)-alkoxy-, (C.sub.1-C.sub.8)-alkoxycarbonyl-, (C.sub.3-C.sub.8)-cycloalkoxycarbonyl-, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxycarbonyl-, (C2-C.sub.8)-alkenyloxycarbonyl-, hydroxycarbonyl-, aminocarbonyl-, (C.sub.1-C.sub.8)-alkylaminocarbonyl-, (C.sub.3-C.sub.8)-cycloalkylaminocarbonyl-, aryl-(C.sub.1-C.sub.8)-alkylaminocarbonyl-substituted three- to eight-membered ring optionally interrupted by O, S or N, or R.sup.9 and R.sup.10 together form an N-(bis-(C.sub.1-C.sub.6)-alkyl)sulphanylidene, N-(aryl-(C.sub.1-C.sub.6)-alkyl)sulphanylidene, N-(bis-(C.sub.3-C.sub.7)-cycloalkyl)sulphanylidene, N((C.sub.1-C.sub.6)-alkyl-(C.sub.3-C.sub.7)-cycloalkyl)sulphanylidene group or an N,N-di-(C.sub.1-C.sub.6)-alkylformylidene group and R.sup.11 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl.

3. Cyanocycloalkylpenta-2,4-dienes, cyanocycloalkylpent-2-en-4-ynes, cyanoheterocyclylpenta-2,4-dienes and cyanoheterocyclylpent-2-en-4-ynes according to claim 1, where [X-Y] represents the moieties ##STR00617## Q represents the moieties ##STR00618## where R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are each as defined below and where the arrow represents a bond to the respective [X-Y] moiety, R.sup.1 is hydrogen, (C.sub.1-C.sub.7)-alkyl, aryl, heteroaryl, heterocyclyl, (C.sub.3-C.sub.10)-cycloalkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, hydroxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkyl, (C.sub.2-C.sub.7)-haloalkenyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-halocycloalkyl, (C.sub.4-C.sub.7)-cycloalkenyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, R.sup.2 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.1-C.sub.7)-alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, (C.sub.3-C.sub.7)-cycloalkylcarbonyl, (C.sub.2-C.sub.7)-alkenylcarbonyl, heterocyclylcarbonyl, (C.sub.1-C.sub.7)-alkoxycarbonyl, (C.sub.2-C.sub.7)-alkenyloxycarbonyl, aryloxy-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl, (C.sub.3-C.sub.7)-cycloalkoxycarbonyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, tris[(C.sub.1-C.sub.7)-alkyl]silyl, (C.sub.1-C.sub.7)-alkylbis[(C.sub.1-C.sub.7)-alkyl]silyl, (C.sub.1-C.sub.7)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.7)-alkyl]silyl, (C.sub.3-C.sub.7)-cycloalkylbis[(C.sub.1-C.sub.7)-alkyl]silyl, halobis[(C.sub.1-C.sub.7)-alkyl]silyl, tris[(C.sub.1-C.sub.7)-alkyl]silyl-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, tris[(C.sub.1-C.sub.7)-alkyl]silyl-(C.sub.1-C.sub.7)-alkyl, A.sup.1, A.sup.2, V, W are each independently a CR.sup.3R.sup.4 group, oxygen or sulphur, where not more than 2 oxygen or 2 sulphur atoms are present in the ring formed by the A.sup.1, A.sup.2, V, W groups and the carbon atom to which they are bonded, and where the oxygen and sulphur atoms are not adjacent to one another, m is 0, 1, 2, n is 0, 1, 2, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1-C.sub.7)-alkyl, halogen, (C.sub.3-C.sub.7)-cycloalkyl, (C.sub.1-C.sub.7)-alkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio, (C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-haloalkyloxy, (C.sub.1-C.sub.7)-haloalkylthio, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.2-C.sub.7)-alkenyl, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.5 and R.sup.6 are each independently hydrogen, halogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkyl, (C.sub.3-C.sub.7)-cycloalkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, R.sup.7 is hydrogen, halogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.7)-haloalkoxy, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-alkynyloxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-alkenyloxy-(C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-alkylthio, (C.sub.1-C.sub.7)-haloalkylthio, optionally substituted phenyl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, heterocyclyl, (C.sub.1-C.sub.7)-alkoxy, hydroxyl, (C.sub.1-C.sub.7)-alkylcarbonyloxy, arylcarbonyloxy, (C.sub.3-C.sub.7)-cycloalkylcarbonyloxy, tris[(C.sub.1-C.sub.7)-alkyl]silyloxy, bis[(C.sub.1-C.sub.7)-alkyl]-[(C.sub.1-C.sub.7)-alkyl]silyloxy, (C.sub.1-C.sub.7)-alkylbisarylsilyloxy, arylbis[(C.sub.1-C.sub.7)-alkyl]silyloxy, (C.sub.3-C.sub.7)-cycloalkylbis[(C.sub.1-C.sub.7)-alkyl]silyloxy, halobis[(C.sub.1-C.sub.7)-alkyl]silyloxy, tris[(C.sub.1-C.sub.7)-alkyl]silyl-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyloxy, tris[(C.sub.1-C.sub.7)-alkyl]silyl-(C.sub.1-C.sub.7)-alkyloxy, (C.sub.3-C.sub.7)-cycloalkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, R.sup.6 and R.sup.7 together with the atoms to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution, R.sup.8 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, optionally substituted phenyl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, bisaryl-(C.sub.1-C.sub.7)-alkyl, trisaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkenyl, (C.sub.4-C.sub.7)-cycloalkenyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkynyl-(C.sub.1-C.sub.7)-alkyl, tri-(C.sub.1-C.sub.7)-alkylsilyl-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkyl, arylsulphonyl-(C.sub.1-C.sub.7)-alkyl, tri-(C.sub.1-C.sub.7)-alkylsilyl, (C.sub.1-C.sub.7)-alkyl(bisaryl)silyl, (C.sub.1-C.sub.7)-alkyl(bis-(C.sub.1-C.sub.7)-alkyl)silyl, bis(C.sub.1-C.sub.7)-alkylamino-(C.sub.1-C.sub.7)-alkyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.2-C.sub.7)-alkynyl, cyano-(C.sub.1-C.sub.7)-alkyl, heterocyclyl, optionally further-substituted phenyl, R.sup.9 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl, halogen, (C.sub.2-C.sub.7)-alkynyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-haloalkyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.2-C.sub.7)-alkenyl, cyano-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylcarbonyl, (C.sub.1-C.sub.7)-alkoxycarbonyl, (C.sub.2-C.sub.7)-alkenyloxycarbonyl, (C.sub.2-C.sub.7)-alkenyl-(C.sub.1-C.sub.7)-alkyloxycarbonyl, aryl-(C.sub.1-C.sub.7)-alkyloxycarbonyl, (C.sub.3-C.sub.7)-cycloalkoxycarbonyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkoxycarbonyl, (C.sub.1-C.sub.7)-alkylsulphonyl, arylsulphonyl, (C.sub.3-C.sub.7)-cycloalkylsulphonyl, (C.sub.1-C.sub.7)-alkylsulphinyl, arylsulphinyl, (C.sub.3-C.sub.7)-cycloalkylsulphinyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, hydroxycarbonyl-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.3-C.sub.7)-cycloalkyl, hydroxycarbonyl-(C.sub.3-C.sub.7)-cycloalkyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.3-C.sub.7)-cycloalkyl, (C.sub.2-C.sub.7)-alkenyloxycarbonyl-(C.sub.3-C.sub.7)-cycloalkyl, aminocarbonyl-(C.sub.3-C.sub.7)-cycloalkyl, (C.sub.1-C.sub.7)-alkylaminocarbonyl-(C.sub.3-C.sub.7)-cycloalkyl, (C.sub.3-C.sub.7)-cycloalkylaminocarbonyl-(C.sub.3-C.sub.7)-cycloalkyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.4-C.sub.7)-cycloalkenyl, hydroxycarbonyl-(C.sub.4-C.sub.7)-cycloalkenyl, bis-(C.sub.1-C.sub.7)-alkylamino-(C.sub.1-C.sub.7)-alkyl, hydroxycarbonylheterocyclyl, (C.sub.1-C.sub.7)-alkoxycarbonylheterocyclyl, (C.sub.2-C.sub.7)-alkenyloxycarbonylheterocyclyl, (C.sub.2-C.sub.7)-alkenyl-(C.sub.1-C.sub.7)-alkoxycarbonylheterocyclyl, aryl-(C.sub.1-C.sub.7)-alkoxycarbonylheterocyclyl, (C.sub.3-C.sub.7)-cycloalkoxycarbonylheterocyclyl, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkoxycarbonylheterocyclyl, aminocarbonylheterocyclyl, (C.sub.1-C.sub.7)-alkylaminocarbonylheterocyclyl, bis-(C.sub.1-C.sub.7)-alkylaminocarbonylheterocyclyl, (C.sub.3-C.sub.7)-cycloalkylaminocarbonylheterocyclyl, aryl-(C.sub.1-C.sub.7)-alkylaminocarbonylheterocyclyl, (C.sub.2-C.sub.7)-alkenylaminocarbonylheterocyclyl, hydroxycarbonylheterocyclyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxycarbonylheterocyclyl-(C.sub.1-C.sub.7)-alkyl, hydroxycarbonyl-(C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkyl, hydroxyl, (C.sub.1-C.sub.7)-alkoxy, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.7)-alkyl, optionally substituted phenyl, R.sup.10 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl, halogen, (C.sub.1-C.sub.7)-haloalkyl, (C.sub.2-C.sub.7)-alkynyl, (C.sub.2-C.sub.7)-alkenyl, cyano-(C.sub.1-C.sub.7)-alkyl, aryl-(C.sub.1-C.sub.7)-alkyl, heteroaryl-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylcarbonyl, (C.sub.1-C.sub.7)-alkoxycarbonyl, (C.sub.1-C.sub.7)-alkylsulphonyl, arylsulphonyl, (C.sub.3-C.sub.7)-cycloalkylsulphonyl, (C.sub.1-C.sub.7)-alkylsulphinyl, arylsulphinyl, (C.sub.3-C.sub.7)-cycloalkylsulphinyl, (C.sub.1-C.sub.7)-alkoxycarbonyl-(C.sub.1-C.sub.7)-alkyl, R.sup.9 and R.sup.10 together with the nitrogen to which they are bonded form an optionally halogen-, (C.sub.1-C.sub.7)-alkyl-, (C.sub.1-C.sub.7)-haloalkyl-, (C.sub.1-C.sub.7)-alkoxy-, (C.sub.1-C.sub.7)-alkoxycarbonyl-, (C.sub.3-C.sub.7)-cycloalkoxycarbonyl-, (C.sub.3-C.sub.7)-cycloalkyl-(C.sub.1-C.sub.7)-alkoxycarbonyl-, (C.sub.2-C.sub.7)-alkenyloxycarbonyl-, hydroxycarbonyl-, aminocarbonyl-, (C.sub.1-C.sub.7)-alkylaminocarbonyl-, (C.sub.3-C.sub.7)-cycloalkylaminocarbonyl-, aryl-(C.sub.1-C.sub.7)-alkylaminocarbonyl-substituted three- to eight-membered ring optionally interrupted by O, S or N, or R.sup.9 and R.sup.10 together form an N-(bis-(C.sub.1-C.sub.6)-alkyl)sulphanylidene, N-(aryl-(C.sub.1-C.sub.6)-alkyl)sulphanylidene, N-(bis-(C.sub.3-C.sub.7)-cycloalkyl)sulphanylidene, N((C.sub.1-C.sub.6)-alkyl-(C.sub.3-C.sub.7)-cycloalkyl)sulphanylidene group or an N,N-di-(C.sub.1-C.sub.6)-alkylformylidene group and R.sup.11 is hydrogen, (C.sub.1-C.sub.7)-alkyl, (C.sub.3-C.sub.7)-cycloalkyl, (C.sub.1-C.sub.7)-haloalkyl, (C.sub.1-C.sub.7)-alkoxy-(C.sub.1-C.sub.7)-alkyl, (C.sub.1-C.sub.7)-alkylthio-(C.sub.1-C.sub.7)-alkyl.

4. Use of one or more compounds of the formula (I) or salts thereof according to claim 1 for increasing tolerance to abiotic stress in plants.

5. Treatment of plants comprising the application of a nontoxic amount, effective for enhancing the resistance of plants to abiotic stress factors, of one or more of the compounds of the general formula (I) or salts thereof according to claim 1.

6. Treatment according to claim 5, wherein the abiotic stress conditions correspond to one or more conditions selected from the group of heat, drought, cold and drought stress, osmotic stress, waterlogging, elevated soil salinity, elevated exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients.

7. Use of one or more compounds of the general formula (I) or salts thereof according to claim 1 in spray application to plants and plant parts in combinations with one or more active ingredients selected from the group of insecticides, attractants, acaricides, fungicides, nematicides, herbicides, growth regulators, safeners, substances which influence plant maturity and bactericides.

8. Use of one or more of the compounds of the general formula (I) or salts thereof according to claim 1 in spray application to plants and plant parts in combinations with fertilizers.

9. Use of one or more of the compounds of the general formula (I) or salts thereof according to claim 1 for application to genetically modified cultivars, the seed thereof, or to cultivated areas in which these cultivars grow.

10. Spray solution for treatment of plants, comprising an amount, effective for enhancing the resistance of plants to abiotic stress factors, of one or more compounds of the general formula (I) according to claim 1 or salts thereof.

11. Use of spray solutions comprising one or more of the compounds of the general formula (I) according to claim 1 or salts thereof for enhancing the resistance of plants to abiotic stress factors.

12. Method for increasing stress tolerance in plants selected from the group of useful plants, ornamental plants, turfgrass types and trees, which comprises the application of a sufficient, nontoxic amount of one or more compounds of the general formula (I) according to claim 1 or salts thereof to the area where the corresponding effect is desired, involving application to the plants, the seed thereof or to the area in which the plants grow.

13. Method according to claim 12, wherein the resistance of the plants thus treated to abiotic stress is increased by at least 3% compared to untreated plants under otherwise identical physiological conditions.

14. Compounds of the general formula (II) or salts thereof ##STR00619## where R.sup.1 is hydrogen, (C.sub.1-C.sub.8)-alkyl, aryl, heteroaryl, heterocyclyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkynyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, hydroxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-halocycloalkyl, (C.sub.4-C.sub.8)-cycloalkenyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, R.sup.2 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.2-C.sub.8)-alkenylcarbonyl, heterocyclylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl, aryloxy-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.1-C.sub.8)-alkylbis[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.1-C.sub.8)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.3-C.sub.8)-cycloalkylbis[(C.sub.1-C.sub.8)-alkyl]silyl, halobis[(C.sub.1-C.sub.8)-alkyl]silyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkyl, A.sup.1, A.sup.2, V, W are each independently a CR.sup.3R.sup.4 group, oxygen or sulphur, where not more than 2 oxygen or 2 sulphur atoms are present in the ring formed by the A.sup.1, A.sup.2, V, W groups and the carbon atom to which they are bonded, and where the oxygen and sulphur atoms are not adjacent to one another, m is 0, 1, 2, n is 0, 1, 2, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1-C.sub.8)-alkyl, halogen, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.1-C.sub.8)-alkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkyloxy, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl and R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution.

15. Compounds of the formula (II) according to claim 14, where R.sup.1 is hydrogen, (C.sub.1-C.sub.6)-alkyl, aryl, heteroaryl, heterocyclyl, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-alkynyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, hydroxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-halocycloalkyl, (C.sub.4-C.sub.6)-cycloalkenyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, R.sup.2 is hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.6)-alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, (C.sub.3-C.sub.6)-cycloalkylcarbonyl, (C.sub.2-C.sub.6)-alkenylcarbonyl, heterocyclylcarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.2-C.sub.6)-alkenyloxycarbonyl, aryloxy-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.3-C.sub.6)-cycloalkoxycarbonyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkylbis[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.3-C.sub.6)-cycloalkylbis[(C.sub.1-C.sub.6)-alkyl]silyl, halobis[(C.sub.1-C.sub.6)-alkyl]silyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl-(C.sub.1-C.sub.6)-alkyl, A.sup.1, A.sup.2, V, W are each independently a CR.sup.3R.sup.4 group, oxygen or sulphur, where not more than 2 oxygen or 2 sulphur atoms are present in the ring formed by the A.sup.1, A.sup.2, V, W groups and the carbon atom to which they are bonded, and where the oxygen and sulphur atoms are not adjacent to one another, m is 0, 1, 2, n is 0, 1, 2, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1-C.sub.6)-alkyl, halogen, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.1-C.sub.6)-alkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkyloxy, (C.sub.1-C.sub.6)-haloalkylthio, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl and R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution.

16. Compounds of the general formula (III) or salts thereof ##STR00620## where R.sup.1 is hydrogen, (C.sub.1-C.sub.8)-alkyl, aryl, heteroaryl, heterocyclyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkynyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, hydroxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-halocycloalkyl, (C.sub.4-C.sub.8)-cycloalkenyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, R.sup.2 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.2-C.sub.8)-alkenylcarbonyl, heterocyclylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl, aryloxy-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, aryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.1-C.sub.8)-alkylbis[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.1-C.sub.8)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.8)-alkyl]silyl, (C.sub.3-C.sub.8)-cycloalkylbis[(C.sub.1-C.sub.8)-alkyl]silyl, halobis[(C.sub.1-C.sub.8)-alkyl]silyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, tris[(C.sub.1-C.sub.8)-alkyl]silyl-(C.sub.1-C.sub.8)-alkyl, A.sup.1, A.sup.2, V, W are each independently a CR.sup.3R.sup.4 group, oxygen or sulphur, where not more than 2 oxygen or 2 sulphur atoms are present in the ring formed by the A.sup.1, A.sup.2, V, W groups and the carbon atom to which they are bonded, and where the oxygen and sulphur atoms are not adjacent to one another, m is 0, 1, 2, n is 0, 1, 2, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1-C.sub.8)-alkyl, halogen, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.1-C.sub.8)-alkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkyloxy, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution and [M] is tris[(C.sub.1-C.sub.6)-alkyl]stannyl, tris[(C.sub.3-C.sub.8)-cycloalkyl]stannyl, tris-[(C.sub.1-C.sub.6)-alkyl]germanyl, tris-[(C.sub.3-C.sub.8)-cycloalkyl]germanyl, bis(cyclopentadienyl)zirconyl, bis(1,2,3,4,5-pentamethylcyclopentadienyl)zirconyl, bis(cyclopentadienyl)hafnyl, bis(1,2,3,4,5-pentamethylcyclopentadienyl)hafnyl, bis(hydroxy)boryl, bis[(C.sub.1-C.sub.6)-alkoxy]boryl, (C.sub.1-C.sub.6)-alkyl-1,3,2-dioxaborolan-2-yl, bis[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborolan-2-yl, tetrakis[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborolan-2-yl, 1,3,2-dioxaborinan-2-yl, bis[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborinan-2-yl, (C.sub.1-C.sub.6)-alkyl-1,3,2-dioxaborinan-2-yl, tris[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborinan-2-yl, 2,6,7-trioxa-1-boranuidabicyclo[2.2.2]octanyl, (C.sub.1-C.sub.6)-alkyl-2,6,7-trioxa-1-boranuidabicyclo[2.2.2]octanyl, tris[(C.sub.1-C.sub.6)-alkyl]plumbanyl, tris[(C.sub.3-C.sub.8)-cycloalkyl]plumbanyl, tris[(C.sub.1-C.sub.6)-alkylcarbonyloxy]plumbanyl, trisarylplumbanyl, bis[(C.sub.1-C.sub.6)-alkylcarbonyloxy]arylplumbanyl, bis[(C.sub.1-C.sub.6)-alkyl]alanyl, bis[(C.sub.1-C.sub.6)-cycloalkyl]alanyl, dichloroalanyl, chloromagnesyl, bromomagnesyl, chlorozincyl, chlorohydrargyl, bromohydrargyl, (C.sub.1-C.sub.6)-alkylhydrargyl, (C.sub.3-C.sub.6)-cycloalkylhydrargyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkyl-[bis-(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.6)-alkyl)]silyl, (C.sub.3-C.sub.7)-cycloalkylbis[(C.sub.1-C.sub.6)-alkyl]silyl.

17. Compounds of the formula (III) according to claim 16, where R.sup.1 is hydrogen, (C.sub.1-C.sub.6)-alkyl, aryl, heteroaryl, heterocyclyl, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-alkynyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, hydroxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-halocycloalkyl, (C.sub.4-C.sub.6)-cycloalkenyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy-(C.sub.1-C.sub.8)-haloalkyl, R.sup.2 is hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.6)-alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, (C.sub.3-C.sub.6)-cycloalkylcarbonyl, (C.sub.2-C.sub.6)-alkenylcarbonyl, heterocyclylcarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.2-C.sub.6)-alkenyloxycarbonyl, aryloxy-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.3-C.sub.6)-cycloalkoxycarbonyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxycarbonyl, aryl-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, aryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkylbis[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.3-C.sub.6)-cycloalkylbis[(C.sub.1-C.sub.6)-alkyl]silyl, halobis[(C.sub.1-C.sub.6)-alkyl]silyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl-(C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl-(C.sub.1-C.sub.6)-alkyl, A.sup.1, A.sup.2, V, W are each independently a CR.sup.3R.sup.4 group, oxygen or sulphur, where not more than 2 oxygen or 2 sulphur atoms are present in the ring formed by the A.sup.1, A.sup.2, V, W groups and the carbon atom to which they are bonded, and where the oxygen and sulphur atoms are not adjacent to one another, m is 0, 1, 2, n is 0, 1, 2, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1-C.sub.6)-alkyl, halogen, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.1-C.sub.6)-alkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkyloxy, (C.sub.1-C.sub.6)-haloalkylthio, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, heteroaryl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkoxy-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, R.sup.3 and R.sup.4 together with the atom to which they are bonded form a fully saturated 3- to 6-membered ring optionally interrupted by heteroatoms and optionally having further substitution and [M] is tris[(C.sub.1-C.sub.6)-alkyl]stannyl, tris[(C.sub.3-C.sub.6)-cycloalkyl]stannyl, tris[(C.sub.1-C.sub.6)-alkyl]germanyl, tris[(C.sub.3-C.sub.6)-cycloalkyl]germanyl, bis(cyclopentadienyl)zirconyl, bis(1,2,3,4,5-pentamethylcyclopentadienyl)zirconyl, bis(cyclopentadienyl)hafnyl, bis(1,2,3,4,5-pentamethylcyclopentadienyl)hafnyl, bis(hydroxy)boryl, bis[(C.sub.1-C.sub.6)-alkoxy]boryl, (C.sub.1-C.sub.6)-alkyl-1,3,2-dioxaborolan-2-yl, bis[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborolan-2-yl, tetrakis[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborolan-2-yl, 1,3,2-dioxaborinan-2-yl, bis[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborinan-2-yl, (C.sub.1-C.sub.6)-alkyl-1,3,2-dioxaborinan-2-yl, tris[(C.sub.1-C.sub.6)-alkyl]-1,3,2-dioxaborinan-2-yl, 2,6,7-trioxa-1-boranuidabicyclo[2.2.2]octanyl, (C.sub.1-C.sub.6)-alkyl-2,6,7-trioxa-1-boranuidabicyclo[2.2.2]octanyl, tris[(C.sub.1-C.sub.6)-alkyl]plumbanyl, tris[(C.sub.3-C.sub.6)-cycloalkyl]plumbanyl, tris[(C.sub.1-C.sub.6)-alkylcarbonyloxy]plumbanyl, trisarylplumbanyl, bis[(C.sub.1-C.sub.6)-alkylcarbonyloxy]arylplumbanyl, bis[(C.sub.1-C.sub.6)-alkyl]alanyl, bis[(C.sub.1-C.sub.6)-cycloalkyl]alanyl, dichloroalanyl, chloromagnesyl, bromomagnesyl, chlorozincyl, chlorohydrargyl, bromohydrargyl, (C.sub.1-C.sub.6)-alkylhydrargyl, (C.sub.3-C.sub.6)-cycloalkylhydrargyl, tris[(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkyl-[bis-(C.sub.1-C.sub.6)-alkyl]silyl, (C.sub.1-C.sub.6)-alkylbis(aryl)silyl, arylbis[(C.sub.1-C.sub.6)-alkyl)]silyl, (C.sub.3-C.sub.7)-cycloalkylbis[(C.sub.1-C.sub.6)-alkyl]silyl.

Description

SYNTHESIS EXAMPLES

No. I.1-124: Ethyl (2Z)-6-(1-cyanocyclopropyl)-3-cyclopropyl-6-hydroxy-7-methyloct-2-en-4-ynoate

[0235] ##STR00538##

[0236] Ethyl 3-cyclopropylprop-2-ynoate (2.00 g, 14.48 mmol) was dissolved in conc. acetic acid (15 ml), finely powdered sodium iodide (6.51 g, 43.43 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain ethyl (2Z)-3-cyclopropyl-3-iodoacrylate (3.01 g, 74% of theory) in the form of a viscous oil. Copper(I) iodide (47 mg, 0.25 mmol) and bis(triphenylphosphine)palladium(II) chloride (129 mg, 0.18 mmol) were initially charged under argon in a baked-out round-bottom flask, and abs. toluene (6 ml) and ethyl (2Z)-3-cyclopropyl-3-iodoacrylate (326 mg, 1.23 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclopropanecarbonitrile (200 mg, 1.23 mmol) in abs. toluene (9 ml) and of diisopropylamine (0.34 ml, 2.45 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), ethyl (2Z)-6-(1-cyanocyclopropyl)-3-cyclopropyl-6-hydroxy-7-methyloct-2-en-4-ynoate (190 mg, 47% of theory) was isolated in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.17 (s, 1H), 4.17 (q, 2H), 2.46 (sept, 1H), 2.01 (br. s, 1H, OH), 1.68 (m, 1H), 1.47 (m, 1H), 1.39 (m, 1H), 1.30 (m, 1H), 1.28 (t, 3H), 1.21 (m, 1H), 1.12 (d, 3H), 1.09 (d, 3H), 0.87 (m, 4H).

No. I.1-157: (2Z)-6-(1-Cyanocyclopropyl)-N-cyclopropyl-3-ethyl-6-hydroxy-7-methyloct-2-en-4-ynamide

[0237] ##STR00539##

[0238] N-Cyclopropylpent-2-ynamide (1 equiv) was dissolved in conc. acetic acid (2 ml/mmol), finely powdered sodium iodide (3 equiv) was added and the mixture was stirred at a temperature of 110 C. for 4 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain (2Z)N-cyclopropyl-3-iodopent-2-enamide (77% of theory) in the form of a waxy solid. Copper(I) iodide (4 mg, 0.02 mmol) and bis(triphenylphosphine)palladium(II) chloride (10 mg, 0.02 mmol) were initially charged under argon in a thoroughly baked-out round-bottom flask, and toluene (3 ml) which had been rendered absolute and stored over molecular sieves and (2Z)N-cyclopropyl-3-iodopent-2-enamide (130 mg, 0.49 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclopropanecarbonitrile (80 mg, 0.49 mmol) in abs.

[0239] N,N-dimethylformamide (2 ml) and of diisopropylamine (0.21 ml, 1.47 mmol). The resulting reaction mixture was stirred at room temperature for 17 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), (2Z)-6-(1-cyanocyclopropyl)-N-cyclopropyl-3-ethyl-6-hydroxy-7-methyloct-2-en-4-ynamide (132 mg, 89% of theory) was isolated in the form of a waxy solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.20 (br. m, 1H, NH), 5.95 (s, 1H), 2.82-2.70 (m, 2H), 2.46 (sept, 1H), 2.27 (q, 2H), 1.41 (m, 1H), 1.33 (m, 2H), 1.27 (m, 1H), 1.15 (t, 3H), 1.13 (d, 3H), 1.11 (d, 3H), 0.82 (m, 2H), 0.57 (m, 2H).

No. I.1-236: Ethyl (2Z)-6-(1-cyanocyclopropyl)-6-hydroxy-3-methyl-6-phenylhex-2-en-4-ynoate

[0240] ##STR00540##

[0241] Copper(I) iodide (31 mg, 0.16 mmol) and bis(triphenylphosphine)palladium(II)chloride (85 mg, 0.12 mmol) were initially charged under argon in a round-bottom flask which had been dried by heating, and abs. toluene (4 ml) and ethyl (2Z)-3-iodobut-2-enoate (195 mg, 0.81 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(1-hydroxy-1-phenylprop-2-yn-1-yl)cyclopropanecarbonitrile (160 mg, 0.81 mmol) in abs. toluene (6 ml) and of diisopropylamine (0.23 ml, 1.62 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), ethyl (2Z)-6-(1-cyanocyclopropyl)-6-hydroxy-3-methyl-6-phenylhex-2-en-4-ynoate (320 mg, 42% of theory) was isolated in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.77 (m, 2H), 7.43-7.37 (m, 3H), 6.07 (s, 1H), 4.17 (q, 2H), 3.33 (br. s, 1H, OH), 2.07 (s, 3H), 1.59 (m, 2H), 1.39 (m, 1H), 1.28 (t, 3H), 1.27 (m, 1H).

No. I.1-503: Ethyl (2Z)-6-(1-cyanocyclopropyl)-3-ethyl-6-(4-fluorophenyl)-6-hydroxyhex-2-en-4-ynoate

[0242] ##STR00541##

[0243] Ethyl 3-ethylprop-2-ynoate (700 mg, 5.55 mmol) was dissolved in conc. acetic acid (7 ml), finely powdered sodium iodide (2.49 g, 16.65 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain ethyl (2Z)-3-ethyl-3-iodoacrylate (1000 mg, 67% of theory) in the form of a viscous oil. Copper(I) iodide (4 mg, 0.02 mmol) and bis(triphenylphosphine)palladium(II) chloride (12 mg, 0.02 mmol) were then initially charged under argon in a thoroughly baked-out round-bottom flask, and abs. toluene (3 ml) and ethyl (2Z)-3-ethyl-3-iodoacrylate (148 mg, 0.58 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-[1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl]cyclopropanecarbonitrile (125 mg, 0.58 mmol) in abs. toluene (2 ml) and of diisopropylamine (0.24 ml, 1.74 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), ethyl (2Z)-6-(1-cyanocyclopropyl)-3-ethyl-6-(4-fluorophenyl)-6-hydroxyhex-2-en-4-ynoate (80 mg, 40% of theory) was isolated in the form of a colourless solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.75 (m, 2H), 7.10 (m, 2H), 6.08 (s, 1H), 4.20 (q, 2H), 3.42 (br. s, 1H, OH), 2.35 (q, 2H), 1.56 (m, 2H), 1.31-1.27 (m, 5H), 1.17 (t, 3H).

No. I.1-606: 2-Methoxyethyl (2Z)-6-(1-cyanocyclopropyl)-3-ethyl-6-hydroxy-7-methyloct-2-en-4-ynoate

[0244] ##STR00542##

[0245] 2-Methoxyethyl pent-2-ynoate (1 equiv) was dissolved in conc. acetic acid (1.5 ml/mmol), finely powdered sodium iodide (3 equiv) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain 2-methoxyethyl (2Z)-3-iodopent-2-enoate (69% of theory) in the form of a viscous oil. Copper(I) iodide (6 mg, 0.03 mmol) and bis(triphenylphosphine)palladium(II) chloride (15 mg, 0.02 mmol) were initially charged under argon in a thoroughly baked-out round-bottom flask, and toluene (3 ml) which had been rendered absolute and stored over molecular sieves and 2-methoxyethyl (2Z)-3-iodopent-2-enoate (209 mg, 0.74 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclopropanecarbonitrile (120 mg, 0.74 mmol) in abs. toluene (3 ml) and of diisopropylamine (0.31 ml, 2.21 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), 2-methoxyethyl (2Z)-6-(1-cyanocyclopropyl)-3-ethyl-6-hydroxy-7-methyloct-2-en-4-ynoate (176 mg, 75% of theory) was isolated in the form of a colourless, viscous oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.04 (s, 1H), 4.31 (m, 2H), 3.66 (m, 2H), 3.61 (br. s, 1H, OH), 3.41 (s, 3H), 2.44 (sept, 1H), 2.29 (q, 2H), 1.41 (m, 1H), 1.32 (m, 1H), 1.29 (m, 1H), 1.20 (m, 1H), 1.15 (t, 3H), 1.13 (d, 3H), 1.10 (d, 3H).

No. I.1-708: Methyl (2Z)-6-(1-cyanocyclopropyl)-3,7-diethyl-6-hydroxynon-2-en-4-ynoate

[0246] ##STR00543##

[0247] Methyl pent-2-ynoate (14.48 mmol) was dissolved in conc. acetic acid (15 ml), finely powdered sodium iodide (43.43 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-3-iodopent-2-enoate (about 3.0 g, 72% of theory) in the form of a viscous oil. Copper(I) iodide (5 mg, 0.25 mmol) and bis(triphenylphosphine)palladium(II) chloride (13 mg, 0.02 mmol) were initially charged under argon in a baked-out round-bottom flask, and abs. toluene (2 ml) and methyl (2Z)-3-iodopent-2-enoate (151 mg, 0.63 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(4-ethyl-3-hydroxyhex-1-yn-3-yl)cyclopropanecarbonitrile (120 mg, 0.63 mmol) in abs. toluene (3 ml) and of diisopropylamine (0.26 ml, 1.88 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), methyl (2Z)-6-(1-cyanocyclopropyl)-3,7-diethyl-6-hydroxynon-2-en-4-ynoate (149 mg, 78% of theory) was isolated in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.02 (s, 1H), 3.72 (s, 3H), 2.63 (br. s, 1H, OH), 2.28 (q, 2H), 1.99 (m, 1H), 1.88 (m, 1H), 1.78 (m, 1H), 1.50-1.41 (m, 4H), 1.34 (m, 1H), 1.24 (m, 1H), 1.15 (t, 3H), 1.06 (t, 6H).

No. I.1-828: Methyl (2Z)-6-(1-cyanocyclopropyl)-6-cyclopentyl-3-ethyl-6-hydroxyhex-2-en-4-ynoate

[0248] ##STR00544##

[0249] Methyl pent-2-ynoate (14.48 mmol) was dissolved in conc. acetic acid (15 ml), finely powdered sodium iodide (43.43 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-3-iodopent-2-enoate (about 3.0 g, 72% of theory) in the form of a viscous oil. Copper(I) iodide (4 mg, 0.21 mmol) and bis(triphenylphosphine)palladium(II) chloride (11 mg, 0.02 mmol) were initially charged under argon in a baked-out round-bottom flask, and abs. toluene (2 ml) and methyl (2Z)-3-iodopent-2-enoate (127 mg, 0.53 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(1-cyclopentyl-1-hydroxyprop-2-yn-1-yl)cyclopropanecarbonitrile (100 mg, 0.53 mmol) in abs. toluene (3 ml) and of diisopropylamine (0.22 ml, 1.58 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), methyl (2Z)-6-(1-cyanocyclopropyl)-6-cyclopentyl-3-ethyl-6-hydroxyhex-2-en-4-ynoate (128 mg, 80% of theory) was isolated in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.02 (s, 1H), 3.72 (s, 3H), 2.70 (m, 1H), 2.64 (br. s, 1H, OH), 2.29 (q, 2H), 1.94 (m, 2H), 1.72-1.58 (m, 6H), 1.48-1.41 (m, 2H), 1.28 (m, 1H), 1.21 (m, 1H), 1.14 (t, 3H).

No. I.2-101: (2Z,4E)-6-(1-Cyanocyclopropyl)-3-ethyl-6-hydroxy-7-methylocta-2,4-dienoic acid

[0250] ##STR00545##

[0251] Pent-2-ynecarboxylic acid (1500 mg, 15.2 mmol) was dissolved in conc. acetic acid (15 ml), finely powdered sodium iodide (6876 mg, 45.8 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain (2Z)-3-iodopent-2-enoic acid (2100 mg, 58% of theory) in the form of a colourless solid. 1-[(1E)-3-Hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclopropanecarbonitrile (390 mg, 0.86 mmol) and (2Z)-3-iodopent-2-enoic acid (194 mg, 0.86 mmol) were dissolved in abs. N,N-dimethylformamide (4 ml) under argon in a baked-out round-bottom flask, dichlorobis(acetonitrile)palladium(II) (7 mg, 0.03 mmol) and copper(I) iodide (131 mg, 0.80 mmol) were added and the mixture was stirred at room temperature for 8 h. After the addition of aqueous potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain (2Z,4E)-6-(1-cyanocyclopropyl)-3-ethyl-6-hydroxy-7-methylocta-2,4-dienoic acid (83 mg, 37% of theory) in the form of a colourless viscous oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.63 (d, 1H), 6.28 (d, 1H), 5.81 (s, 1H), 2.97 (br. s, 1H, OH), 2.89 (br. s, 1H, OH), (s, 3H), 2.43 (q, 2H), 2.38 (sept, 1H), 1.33 (m, 1H) 1.21 (m, 1H), 1.18 (t, 3H), 1.09 (d, 3H), 1.05 (m, 1H), 0.97 (d, 3H).

No. I.2-120: Methyl (2E,4E)-6-(1-cyanocyclopropyl)-6-hydroxy-7-methyl-3-(trifluoro-methyl)octa-2,4-dienoate

[0252] ##STR00546##

[0253] Methyl 4,4,4-trifluorobut-2-ynoate (500 mg, 3.01 mmol) was dissolved in conc. acetic acid (6 ml), finely powdered sodium iodide (1353 mg, 9.03 mmol) was added and the mixture was stirred at a temperature of 110 C. for 4 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (380 mg, 43% of theory) in the form of a viscous oil. 1-[(1E)-3-Hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclopropanecarbonitrile (300 mg, 0.66 mmol) and methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (185 mg, 0.66 mmol) were dissolved in abs. N,N-dimethylformamide (20 ml) under argon in a baked-out round-bottom flask, tetrakis(triphenylphosphine)palladium(0) (76 mg, 0.07 mmol) and copper(I) iodide (94 mg, 0.49 mmol) were added and the mixture was stirred at room temperature for 16 h. After the addition of aqueous potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2E,4E)-6-(1-cyanocyclopropyl)-6-hydroxy-7-methyl-3-(trifluoromethyl)octa-2,4-dienoate (53 mg, 25% of theory) in the form of a colourless viscous oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.44 (d, 1H), 6.36 (d, 1H), 6.32 (s, 1H), 3.80 (s, 3H), 2.42 (sept, 1H), 1.63 (br. s, 1H, OH), 1.27 (m, 1H) 1.22 (m, 1H), 1.12 (m, 1H), 1.05 (d, 3H), 0.99 (m, 1H), 0.97 (d, 3H).

No. I.2-136: Ethyl (2Z,4E)-6-(1-cyanocyclopropyl)-6-hydroxy-3,7-dimethylocta-2,4-dienoate

[0254] ##STR00547##

[0255] Ethyl 2-butynoate (3.00 g, 26.76 mmol) was dissolved in conc. acetic acid (25 ml), finely powdered sodium iodide (12.03 g, 80.27 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain ethyl (2Z)-3-iodobut-2-enoate (5.58 g, 79% of theory) in the form of a viscous oil. 1-[(1E)-3-Hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclopropanecarbonitrile (160 mg, 0.35 mmol) and ethyl (2Z)-3-iodobut-2-enoate (85 mg, 0.35 mmol) were dissolved in abs. tetrahydrofuran (5 ml) under argon in a baked-out round-bottom flask, dichlorobis(acetonitrile)palladium(II) (5 mg, 0.02 mmol) was added and the mixture was stirred at room temperature for 4 h. After the addition of potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with diethyl ether, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain ethyl (2Z,4E)-6-(1-cyanocyclopropyl)-6-hydroxy-3,7-dimethylocta-2,4-dienoate (30 mg, 29% of theory) in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.77 (d, 1H), 6.25 (d, 1H), 5.74 (s, 1H), 4.29 (q, 2H), 2.39 (sept, 1H), 2.22 (br. s, 1H, OH), 2.04 (s, 3H), 1.34 (m, 1H), 1.29 (t, 3H), 1.20 (m, 1H), 1.06 (d, 3H), 1.03 (m, 1H), 0.97 (m, 1H), 0.93 (d, 3H).

No. I.2-534: Methyl (2E,4E)-6-(1-cyanocyclopropyl)-6-cyclopropyl-6-hydroxy-3-(trifluoromethyl)hexa-2,4-dienoate

[0256] ##STR00548##

[0257] Methyl 4,4,4-trifluorobut-2-ynoate (500 mg, 3.01 mmol) was dissolved in conc. acetic acid (6 ml), finely powdered sodium iodide (1353 mg, 9.03 mmol) was added and the mixture was stirred at a temperature of 110 C. for 4 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (380 mg, 43% of theory) in the form of a viscous oil. 1-[(2E)-1-Cyclopropyl-1-hydroxy-3-(tributylstannyl)prop-2-en-1-yl]cyclopropanecarbonitrile (200 mg, 0.44 mmol) and methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (124 mg, 0.44 mmol) were dissolved in abs. N,N-dimethylformamide (5 ml) under argon in a baked-out round-bottom flask, dichlorobis(acetonitrile)palladium(II) (4 mg, 0.01 mmol) and copper(I) iodide (67 mg, 0.35 mmol) were added and the mixture was stirred at room temperature for 12 h. After the addition of aqueous potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2E,4E)-6-(1-cyanocyclopropyl)-6-cyclopropyl-6-hydroxy-3-(trifluoromethyl)hexa-2,4-dienoate (79 mg, 57% of theory) in the form of a colourless viscous oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.56 (d, 1H), 6.33 (s, 1H), 6.27 (d, 1H), 3.80 (s, 3H), 1.63 (br. s, 1H, OH), 1.32-1.24 (m, 4H) 1.22-1.13 (m, 3H), 0.51 (m, 2H).

No. I.2-579: Methyl (2Z,4E)-6-(1-cyanocyclopropyl)-6-cyclohexyl-3-ethyl-6-hydroxyhexa-2,4-dienoate

[0258] ##STR00549##

[0259] Methyl pent-2-ynoate (14.48 mmol) was dissolved in conc. acetic acid (15 ml), finely powdered sodium iodide (43.43 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-3-iodopent-2-enoate (about 3.0 g, 72% of theory) in the form of a viscous oil. 1-[(2E)-1-Cyclohexyl-1-hydroxy-3-(tributylstannyl)prop-2-en-1-yl]cyclopropanecarbonitrile (Ex. No. III.1-66, 450 mg, 0.91 mmol) and methyl (2Z)-3-iodopent-2-enoate (219 mg, 0.91 mmol) were dissolved in abs. N,N-dimethylformamide (5 ml) under argon in a baked-out round-bottom flask, dichlorobis(acetonitrile)palladium(II) (7 mg, 0.03 mmol) and copper(I) iodide (139 mg, 0.73 mmol) were added and the mixture was stirred at room temperature for 12 h. After the addition of aqueous potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z,4E)-6-(1-cyanocyclopropyl)-6-cyclohexyl-3-ethyl-6-hydroxyhexa-2,4-dienoate (105 mg, 36% of theory) in the form of a colourless viscous oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.66 (d, 1H), 6.26 (d, 1H), 5.73 (s, 1H), 3.72 (s, 3H), 2.43 (m, 2H), 2.08-1.97 (m, 2H), 1.81 (m, 2H), 1.71 (m, 2H), 1.64 (br. s, 1H, OH), 1.39-1.26 (m, 4H), 1.19 (m, 1H), 1.16 (t, 3H), 1.09 (m, 1H), 1.02-0.93 (m, 3H).

No. I.2-585: Methyl (2E,4E)-6-(1-cyanocyclopropyl)-7-ethyl-6-hydroxy-3-(trifluoromethyl)nona-2,4-dienoate

[0260] ##STR00550##

[0261] Methyl 4,4,4-trifluorobut-2-ynoate (500 mg, 3.01 mmol) was dissolved in conc. acetic acid (6 ml), finely powdered sodium iodide (1353 mg, 9.03 mmol) was added and the mixture was stirred at a temperature of 110 C. for 4 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (380 mg, 43% of theory) in the form of a viscous oil. 1-[(1E)-4-Ethyl-3-hydroxy-1-(tributylstannyl)hex-1-en-3-yl]cyclopropanecarbonitrile (325 mg, 0.67 mmol) and methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (189 mg, 0.67 mmol) were dissolved in abs. N,N-dimethylformamide (5 ml) under argon in a baked-out round-bottom flask, dichlorobis(acetonitrile)palladium(II) (5 mg, 0.02 mmol) and copper(I) iodide (103 mg, 0.54 mmol) were added and the mixture was stirred at room temperature for 12 h. After the addition of aqueous potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2E,4E)-6-(1-cyanocyclopropyl)-7-ethyl-6-hydroxy-3-(trifluoromethyl)nona-2,4-dienoate (88 mg, 38% of theory) in the form of a colourless viscous oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.45 (d, 1H), 6.35 (d, 1H), 6.31 (s, 1H), 3.80 (s, 3H), 1.93 (m, 1H), 1.78 (m, 1H), 1.64 (m, 1H), 1.59 (br. s, 1H, OH), 1.38 (m, 1H), 1.32-1.22 (m, 4H) 1.13 (m, 1H), 1.06 (t, 3H), 0.99 (t, 3H).

No. I.2-618: Ethyl (2E,4E)-6-(1-cyanocyclopropyl)-6-cyclopentyl-6-hydroxy-3-(trifluoromethyl)hexa-2,4-dienoate

[0262] ##STR00551##

Ethyl 4,4,4-trifluorobut-2-ynoate (500 mg, 3.01 mmol) was dissolved in conc. acetic acid (6 ml), finely powdered sodium iodide (1353 mg, 9.03 mmol) was added and the mixture was stirred at a temperature of 110 C. for 4 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain ethyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (380 mg, 45% of theory) in the form of a viscous oil. 1-[(2E)-1-Cyclopentyl-1-hydroxy-3-(tributylstannyl)prop-2-en-1-yl]cyclopropanecarbonitrile (350 mg, 0.73 mmol) and ethyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (214 mg, 0.73 mmol) were dissolved in abs. N,N-dimethylformamide (4 ml) under argon in a baked-out round-bottom flask, dichlorobis(acetonitrile)palladium(II) (6 mg, 0.02 mmol) and copper(I) iodide (111 mg, 0.58 mmol) were added and the mixture was stirred at room temperature for 12 h. After the addition of aqueous potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain ethyl (2E,4E)-6-(1-cyanocyclopropyl)-6-cyclopentyl-6-hydroxy-3-(trifluoromethyl)hexa-2,4-dienoate (84 mg, 32% of theory) in the form of a colourless viscous oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.49 (d, 1H), 6.41 (d, 1H), 6.31 (s, 1H), 4.26 (q, 2H), 2.69-2.63 (m, 1H), 1.95-1.88 (m, 1H), 1.68-1.60 (m, 4H), 1.58 (br. s, 1H, OH), 1.48-1.26 (m, 6H) 1.19 (m, 1H), 1.12 (m, 1H), 1.03 (m, 1H).

No. I.3-32: Methyl (2Z)-6-(1-cyanocyclobutyl)-6-hydroxy-7-methyl-3-trifluoromethyloct-2-en-4-ynoate

[0263] ##STR00552##

[0264] Methyl 4,4,4-trifluorobut-2-ynoate (500 mg, 3.01 mmol) was dissolved in conc. acetic acid (6 ml), finely powdered sodium iodide (1353 mg, 9.03 mmol) was added and the mixture was stirred at a temperature of 110 C. for 4 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (380 mg, 43% of theory) in the form of a viscous oil. Copper(I) iodide (6 mg, 0.03 mmol) and bis(triphenylphosphine)palladium(II) chloride (18 mg, 0.03 mmol) were initially charged under argon in a baked-out round-bottom flask, and abs. toluene (6 ml) and methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (237 mg, 0.85 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclobutanecarbonitrile (150 mg, 0.85 mmol) in abs. toluene (7 ml) and of diisopropylamine (0.36 ml, 2.54 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), methyl (2Z)-6-(1-cyanocyclobutyl)-6-hydroxy-7-methyl-3-trifluoromethyloct-2-en-4-ynoate (147 mg, 53% of theory) was isolated in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.71 (s, 1H), 3.83 (s, 3H), 2.79-2.68 (m, 2H), 2.47 (br. s, 1H, OH), 2.41 (m, 4H), 2.32 (m, 2H), 1.94 (m, 1H), 1.13 (d, 3H), 1.03 (d, 3H).

No. I.3-44: Methyl (2Z)-6-(1-cyanocyclobutyl)-3-ethyl-6-hydroxy-6-phenylhex-2-en-4-ynoate

[0265] ##STR00553##

[0266] Methyl pent-2-ynoate (14.48 mmol) was dissolved in conc. acetic acid (15 ml), finely powdered sodium iodide (43.43 mmol) was added and the mixture was stirred at a temperature of 110 C. for 3 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-3-iodopent-2-enoate (about 3.0 g, 72% of theory) in the form of a viscous oil. Copper(I) iodide (4 mg, 0.23 mmol) and bis(triphenylphosphine)palladium(II) chloride (12 mg, 0.02 mmol) were initially charged under argon in a baked-out round-bottom flask, and abs. toluene (3 ml) and methyl (2Z)-3-iodopent-2-enoate (136 mg, 0.57 mmol) were added. Stirring at room temperature for 10 min was followed by the dropwise addition of a solution of 1-(1-hydroxy-1-phenylprop-2-yn-1-yl)cyclobutanecarbonitrile (120 mg, 0.57 mmol) in abs. toluene (3 ml) and of diisopropylamine (0.24 ml, 1.70 mmol). The resulting reaction mixture was stirred at room temperature for 3 h and then water was added. The aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the crude product obtained (using an ethyl acetate/heptane gradient), methyl (2Z)-6-(1-cyanocyclobutyl)-3-ethyl-6-hydroxy-6-phenylhex-2-en-4-ynoate (128 mg, 80% of theory) was isolated in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.76 (m, 2H), 7.42-7.37 (m, 3H), 6.10 (s, 1H), 3.73 (s, 3H), 3.34 (br. s, 1H, OH), 2.88-2.75 (m, 2H), 2.42-2.38 (q, 2H), 2.34-2.25 (m, 2H), 2.23-2.14 (m, 1H), 1.95-1.88 (m, 1H), 1.21 (t, 3H).

No. 1.4-32: Methyl (2E,4E)-6-(1-cyanocyclobutyl)-6-hydroxy-7-methyl-3-(trifluoromethyl)octa-2,4-dienoate

[0267] ##STR00554##

[0268] Methyl 4,4,4-trifluorobut-2-ynoate (500 mg, 3.01 mmol) was dissolved in conc. acetic acid (6 ml), finely powdered sodium iodide (1353 mg, 9.03 mmol) was added and the mixture was stirred at a temperature of 110 C. for 4 h. After cooling to room temperature, methyl tert-butyl ether (MTBE) and saturated sodium thiosulphate solution were added. The aqueous phase was extracted repeatedly with MTBE, and the combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (380 mg, 43% of theory) in the form of a viscous oil. 1-[(1E)-3-Hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclobutanecarbonitrile (300 mg, 0.64 mmol) and methyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate (179 mg, 0.64 mmol) were dissolved in abs. N,N-dimethylformamide (5 ml) under argon in a baked-out round-bottom flask, dichlorobis(acetonitrile)palladium(II) (5 mg, 0.02 mmol) and copper(I) iodide (98 mg, 0.51 mmol) were added and the mixture was stirred at room temperature for 12 h. After the addition of potassium fluoride solution, stirring of the reaction mixture continued at room temperature for 1 h. The aqueous phase was then repeatedly extracted thoroughly with diethyl ether, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain methyl (2E,4E)-6-(1-cyanocyclobutyl)-6-hydroxy-7-methyl-3-(trifluoromethyl)octa-2,4-dienoate (46 mg, 21% of theory) in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.53 (d, 1H), 6.31 (s, 1H), 6.30 (d, 1H), 3.80 (s, 3H), 2.65 (m, 1H), 2.40 (m, 1H), 2.29 (m, 2H), 2.11 (m, 1H), 1.80 (m, 1H), 1.73 (br. s, 1H, OH), 1.30 (m, 1H), 0.94 (d, 3H), 0.91 (d, 3H).

No. II.1-2: 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclopropanecarbonitrile

[0269] ##STR00555##

[0270] 1-Isobutyrylcyclopropanecarbonitrile (4.00 g, 29.16 mmol) was dissolved in abs. tetrahydrofuran (120 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (4.11 g, 37.91 mmol, content 85%) in abs. tetrahydrofuran (80 ml). On completion of addition, the reaction solution was stirred at room temperature for 4 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclopropanecarbonitrile (2.59 g, 54% of theory) was isolated as a colourless solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 2.48 (s, 1H), 2.41 (sept, 1H), 2.19 (br. s, 1H, OH), 1.34-1.28 (m, 3H), 1.21 (m, 1H), 1.12 (d, 3H), 1.09 (d, 3H).

No. II.1-3: 1-(1-Hydroxy-1-phenylprop-2-yn-1-yl)cyclopropanecarbonitrile

[0271] ##STR00556##

[0272] 1-Benzoylcyclopropanecarbonitrile (4.00 g, 23.37 mmol) was dissolved in abs. tetrahydrofuran (160 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (3.29 g, 37.37 mmol, content 85%) in abs. tetrahydrofuran (80 ml). On completion of addition, the reaction solution was stirred at room temperature for 4 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-(1-hydroxy-1-phenylprop-2-yn-3-yl)cyclopropanecarbonitrile (3.16 g, 69% of theory) was isolated as a colourless solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.70 (m, 2H), 7.41 (m, 2H), 7.29 (m, 1H), 2.78 (s, 1H), 2.62 (br. s, 1H, OH), 1.51 (m, 1H), 1.39 (m, 1H), 1.28 (m, 2H); .sup.13C NMR (150 MHz, CDCl.sub.3 , ppm) 140.1, 129.0, 128.5, 127.2, 125.8, 122.3, 120.9, 86.1, 76.8, 72.0, 22.8, 13.2, 12.7.

No. II.1-5: 1-(1-Cyclopropyl-1-hydroxyprop-2-yn-1-yl)cyclopropanecarbonitrile

[0273] ##STR00557##

[0274] 1-(Cyclopropylcarbonyl)cyclopropanecarbonitrile (9.0 g, 66.59 mmol) was dissolved in abs. tetrahydrofuran (70 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (8.86 g, 86.56 mmol, content 90%) in abs. tetrahydrofuran (50 ml). On completion of addition, the reaction solution was stirred at room temperature for 4 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-(1-cyclopropyl-1-hydroxyprop-2-yn-3-yl)cyclopropanecarbonitrile (0.77 g, 7% of theory) was isolated as a colourless solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 2.46 (s, 1H), 2.15 (br. s, 1H, OH), 1.57 (m, 1H), 1.47-1.34 (m, 2H), 1.28-1.23 (m, 2H), 0.75-0.55 (m, 4H).

No. II.1-7: 1-[1-(4-Fluorophenyl)-1-hydroxyprop-2-yn-1-yl]cyclopropanecarbonitrile

[0275] ##STR00558##

[0276] 1-(4-Fluorobenzoyl)cyclopropanecarbonitrile (7.00 g, 37.00 mmol) was dissolved in abs. tetrahydrofuran (40 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (4.92 g, 48.10 mmol, content 90%) in abs. tetrahydrofuran (20 ml). On completion of addition, the reaction solution was stirred at room temperature for 4 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-[1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl]cyclopropanecarbonitrile (0.84 g, 11% of theory) was isolated as a colourless waxy solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.69 (m, 2H), 7.11 (m, 2H), 2.79 (s, 1H), 2.62 (br. s, 1H, OH), 1.51 (m, 1H), 1.39 (m, 1H), 1.28 (m, 2H).

No. II.1-81: 1-(1-Cyclopentyl-1-hydroxyprop-2-yn-1-yl)cyclopropanecarbonitrile

[0277] ##STR00559##

[0278] 1-(Cyclopentylcarbonyl)cyclopropanecarbonitrile (9.00 g, 55.14 mmol) was dissolved in abs. tetrahydrofuran (50 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (6.59 g, 71.68 mmol) in abs. tetrahydrofuran (40 ml). On completion of addition, the reaction solution was stirred at room temperature for 2 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-(1-cyclopentyl-1-hydroxyprop-2-yn-1-yl)cyclopropanecarbonitrile (2.55 g, 25% of theory) was isolated as a colourless solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 2.65 (m, 1H), 2.47 (s, 1H), 2.18 (br. s, 1H, OH), 1.97-1.85 (m, 2H), 1.73-1.59 (m, 4H), 1.45-1.39 (m, 1H), 1.37-1.33 (m, 2H), 1.30-1.26 (m, 2H), 1.22-1.19 (m, 1H).

No. II.1-84: 1-(4-Ethyl 3-hydroxyhex-1-yn-3-yl)cyclopropanecarbonitrile

[0279] ##STR00560##

[0280] 1-(2-Ethylbutanoyl)cyclopropanecarbonitrile (14.00 g, 84.73 mmol) was dissolved in abs. tetrahydrofuran (50 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (10.14 g, 110.15 mmol, content 85%) in abs. tetrahydrofuran (40 ml). On completion of addition, the reaction solution was stirred at room temperature for 3 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-(4-ethyl 3-hydroxyhex-1-yn-3-yl)cyclopropanecarbonitrile (6.15 g, 38% of theory) was isolated as a colourless solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 2.31 (s, 1H), 2.02 (br. s, 1H, OH), 1.77 (m, 1H), 1.67 (m, 1H), 1.58 (m, 1H), 1.33 (m, 1H), 1.25 (m, 1H), 1.19 (m, 2H), 1.08 (m, 2H), 0.89 (m, 6H).

No. 11.2-2: 1-(3-Hydroxy-4-methylpent-1-yn-3-yl)cyclobutanecarbonitrile

[0281] ##STR00561##

[0282] 1-Isobutyrylcyclobutanecarbonitrile (9.00 g, 60.0 mmol) was dissolved in abs. tetrahydrofuran (50 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (7.92 g, 77.0 mmol, content 90%) in abs. tetrahydrofuran (20 ml). On completion of addition, the reaction solution was stirred at room temperature for 2 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclobutanecarbonitrile (2.50 g, 24% of theory) was isolated as a colourless waxy solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 2.70 (m, 2H), 2.64 (s, 1H), 2.36 (m, 2H), 2.24 (m, 2H), 2.12 (br. s, 1H, OH), 1.08 (d, 3H), 0.98 (d, 3H).

No. 11.2-3:1-(1-Hydroxy-1-phenylprop-2-yn-1-yl)cyclobutanecarbonitrile

[0283] ##STR00562##

[0284] 1-Benzoylcyclobutanecarbonitrile (10.00 g, 53.99 mmol) was dissolved in abs. tetrahydrofuran (50 ml) in a round-bottom flask under argon and added dropwise to a solution, cooled to 0 C., of a lithium acetylide-ethylenediamine complex (7.18 g, 70.19 mmol, content 90%) in abs. tetrahydrofuran (20 ml). On completion of addition, the reaction solution was stirred at room temperature for 3 h, then water was added and the mixture was concentrated under reduced pressure. The remaining residue was admixed with water and dichloromethane, and the aqueous phase was extracted repeatedly with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. By column chromatography purification of the crude product obtained (ethyl acetate/heptane gradient), 1-(1-hydroxy-1-phenylprop-2-yn-1-yl)cyclobutanecarbonitrile (740 mg, 6% of theory) was isolated as a colourless waxy solid. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.69 (m, 2H), 7.42-7.37 (m, 3H), 2.83 (br. s, 1H, OH), 2.80-2.65 (m, 2H), 2.62 (s, 1H), 2.36-2.15 (m, 4H), 1.91-1.84 (m, 2H).

No. III.1-2: 1-[(1E)-3-Hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclopropanecarbonitrile

[0285] ##STR00563##

[0286] Tetrakis(triphenylphosphine)palladium(0) (198 mg, 0.17 mmol) was initially charged under argon in a baked-out round-bottom flask, and abs. tetrahydrofuran (20 ml) and 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclopropanecarbonitrile (560 mg, 3.41 mmol) were added. Stirring at room temperature for 5 minutes was followed by the addition of tributyltin hydride (1.10 ml, 4.12 mmol). The resulting reaction mixture was stirred at room temperature for 1 h and then water was added. The aqueous phase was repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain 1-[(1E)-3-hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclopropanecarbonitrile (0.38 mg, 24% of theory) in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.18 (d, 1H), 6.03 (d, 1H), 2.32 (sept, 1H), 1.53-1.45 (m, 6H), 1.35-1.29 (m, 6H), 1.28 (m, 1H), 1.14 (m, 1H), 1.03 (d, 3H), 0.94-0.88 (m, 18H), 0.72 (m, 2H).

No. III.1-5: 1-[(2E)-1-Cyclopropyl-1-hydroxy-3-(tributylstannyl)prop-2-en-1-yl]cyclopropanecarbonitrile

[0287] ##STR00564##

[0288] Tetrakis(triphenylphosphine)palladium(0) (107 mg, 0.09 mmol) was initially charged under argon in a baked-out round-bottom flask, and abs. tetrahydrofuran (10 ml) and 1-(1-cyclopropyl-1-hydroxyprop-2-yn-1-yl)cyclopropanecarbonitrile (370 mg, 2.29 mmol) were added. Stirring at room temperature for 5 minutes was followed by the addition of tributyltin hydride (0.74 ml, 2.75 mmol). The resulting reaction mixture was stirred at room temperature for 1 h and at a temperature of 50 C. for 30 minutes, and then water was added. The aqueous phase was repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain 1-[(2E)-1-cyclopropyl-1-hydroxy-3-(tributylstannyl)prop-2-en-1-yl]cyclopropanecarbonitrile (202 mg, 19% of theory) in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.33 (d, 1H), 6.00 (d, 1H), 1.56 (br. s, 1H, OH), 1.53-1.45 (m, 7H), 1.35-1.28 (m, 6H), 1.24 (m, 1H), 1.17-1.08 (m, 2H), 1.03 (m, 1H), 0.96-0.86 (m, 15H), 0.57 (m, 1H), 0.47 (m, 2H), 0.41 (m, 1H).

No. III.1-76: 1-[(2E)-1-Cyclopentyl-1-hydroxy-3-(tributylstannyl)prop-2-en-1-yl]cyclopropanecarbonitrile

[0289] ##STR00565##

[0290] Tetrakis(triphenylphosphine)palladium(0) (464 mg, 0.40 mmol) was initially charged under argon in a baked-out round-bottom flask, and abs. tetrahydrofuran (30 ml) and 1-(1-cyclopentyl-1-hydroxyprop-2-yn-1-yl)cyclopropanecarbonitrile (1900 mg, 10.04 mmol) were added. Stirring at room temperature for 5 minutes was followed by the addition of tributyltin hydride (3.24 ml, 12.05 mmol). The resulting reaction mixture was stirred at room temperature for 1 h and then water was added. The aqueous phase was repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain 1-[(2E)-1-cyclopentyl-1-hydroxy-3-(tributylstannyl)prop-2-en-1-yl]cyclopropanecarbonitrile (1650 mg, 34% of theory) in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.19 (d, 1H), 6.13 (d, 1H), 2.63-2.57 (m, 1H), 1.88-1.80 (br. s, 1H, OH), 1.73-1.58 (m, 4H), 1.56-1.47 (m, 8H), 1.37-1.27 (m, 8H), 1.26 (m, 1H), 1.13 (m, 1H), 1.05-0.98 (m, 2H), 0.94-0.86 (m, 15H).

No. III.1-67: 1-[(1E)-4-Ethyl-3-hydroxy-1-(tributylstannyl)hex-1-en-3-yl]cyclopropanecarbonitrile

[0291] ##STR00566##

[0292] Tetrakis(triphenylphosphine)palladium(0) (242 mg, 0.21 mmol) was initially charged under argon in a baked-out round-bottom flask, and abs. tetrahydrofuran (20 ml) and 1-(4-ethyl-3-hydroxyhex-1-yn-3-yl)cyclopropanecarbonitrile (1.00 g, 5.23 mmol) were added. Stirring at room temperature for 5 minutes was followed by the addition of tributyltin hydride (1.69 ml, 6.27 mmol). The resulting reaction mixture was stirred at room temperature for 1 h and at a temperature of 50 C. for 30 minutes, and then water was added. The aqueous phase was repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain 1-[(1E)-4-ethyl-3-hydroxy-1-(tributylstannyl)hex-1-en-3-yl]cyclopropanecarbonitrile (1.34 mg, 53% of theory) in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.16 (d, 1H), 6.07 (d, 1H), 1.83 (m, 1H), 1.74 (m, 1H), 1.60 (m, 1H), 1.53 (br. s, 1H, OH), 1.52-1.46 (m, 4H), 1.37-1.29 (m, 9H), 1.25 (m, 1H), 1.18 (m, 1H), 1.08-0.95 (m, 7H), 0.93-0.87 (m, 16H), 0.82 (m, 1H).

No. III.2-2: 1-[(1E)-3-Hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclobutanecarbonitrile

[0293] ##STR00567##

[0294] Tetrakis(triphenylphosphine)palladium(0) (261 mg, 0.23 mmol) was initially charged under argon in a baked-out round-bottom flask, and abs. tetrahydrofuran (20 ml) and 1-(3-hydroxy-4-methylpent-1-yn-3-yl)cyclobutanecarbonitrile (1000 mg, 5.64 mmol) were added. Stirring at room temperature for 5 minutes was followed by the addition of tributyltin hydride (1.82 ml, 6.77 mmol). The resulting reaction mixture was stirred at room temperature for 1 h and then water was added. The aqueous phase was repeatedly extracted thoroughly with dichloromethane, and the combined organic phases were then dried over magnesium sulphate, filtered and concentrated under reduced pressure. By final column chromatography purification of the resulting crude product (ethyl acetate/heptane gradient), it was possible to obtain 1-[(1E)-3-hydroxy-4-methyl-1-(tributylstannyl)pent-1-en-3-yl]cyclobutanecarbonitrile (1.40 mg, 53% of theory) in the form of a colourless oil. .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.23 (d, 1H), 5.98 (d, 1H), 2.78 (m, 1H), 2.30 (m, 1H), 2.22 (m, 3H), 2.02 (m, 1H), 1.77 (m, 1H), 1.67 (br. s, 1H, OH), 1.53-1.45 (m, 6H), 1.35-1.27 (m, 6H), 0.96-0.85 (m, 21H).

[0295] In analogy to the preparation examples cited above and recited in the tables below, and taking into account the general details regarding the preparation of substituted cyanocycloalkylpenta-2,4-dienes, cyanocycloalkylpent-2-en-4-ynes, cyanoheterocyclylpenta-2,4-dienes and cyanoheterocyclylpent-2-en-4-ynes of the general formula (I) and of the compounds of the general formulae (II) and (III), the following compounds specified in Tables 1 to 8 are obtained:

TABLE-US-00002 TABLE 1 (I) [00568] No. R.sup.1 R.sup.2 A.sup.1 A.sup.2 Q I.1-1 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.1 I.1-2 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.2 I.1-3 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.3 I.1-4 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.16 I.1-5 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.17 I.1-6 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.18 I.1-7 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.31 I.1-8 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.32 I.1-9 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.33 I.1-10 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.91 I.1-11 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.92 I.1-12 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.93 I.1-13 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.106 I.1-14 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.107 I.1-15 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.108 I.1-16 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.121 I.1-17 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.122 I.1-18 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.123 I.1-19 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.136 I.1-20 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.137 I.1-21 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.138 I.1-22 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.166 I.1-23 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.167 I.1-24 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.168 I.1-25 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.171 I.1-26 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.172 I.1-27 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.173 I.1-28 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.176 I.1-29 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.177 I.1-30 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.178 I.1-31 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.181 I.1-32 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.182 I.1-33 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.183 I.1-34 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.201 I.1-35 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.202 I.1-36 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.203 I.1-37 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.204 I.1-38 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.205 I.1-39 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.206 I.1-41 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.207 I.1-42 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.208 I.1-43 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.209 I.1-44 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.210 I.1-45 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.211 I.1-46 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.212 I.1-47 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.213 I.1-48 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.216 I.1-49 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.217 I.1-50 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.218 I.1-51 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.246 I.1-52 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.247 I.1-53 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.248 I.1-54 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.1 I.1-55 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.2 I.1-56 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.3 I.1-57 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.5 I.1-58 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.4 I.1-59 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.7 I.1-60 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.9 I.1-61 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.12 I.1-62 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.13 I.1-63 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.14 I.1-64 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.61 I.1-65 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.62 I.1-66 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.63 I.1-67 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.64 I.1-68 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.65 I.1-69 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.67 I.1-70 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.69 I.1-71 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.72 I.1-72 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.73 I.1-73 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.74 I.1-74 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.80 I.1-75 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.105 I.1-76 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.106 I.1-77 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.108 I.1-78 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.145 I.1-79 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.146 I.1-80 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.147 I.1-81 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.161 I.1-82 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.162 I.1-83 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.163 I.1-84 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.164 I.1-85 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.165 I.1-86 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.167 I.1-87 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.168 I.1-88 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.169 I.1-89 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.172 I.1-90 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.173 I.1-91 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.174 I.1-92 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.180 I.1-93 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.185 I.1-94 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.189 I.1-95 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.190 I.1-96 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.201 I.1-97 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.202 I.1-98 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.203 I.1-99 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.204 I.1-100 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.205 I.1-101 i-Pr H CH.sub.2 CH.sub.2 Q-1.1 I.1-102 i-Pr H CH.sub.2 CH.sub.2 Q-1.2 I.1-103 i-Pr H CH.sub.2 CH.sub.2 Q-1.3 I.1-104 i-Pr H CH.sub.2 CH.sub.2 Q-1.16 I.1-105 i-Pr H CH.sub.2 CH.sub.2 Q-1.17 I.1-106 i-Pr H CH.sub.2 CH.sub.2 Q-1.18 I.1-107 i-Pr H CH.sub.2 CH.sub.2 Q-1.31 I.1-108 i-Pr H CH.sub.2 CH.sub.2 Q-1.32 I.1-109 i-Pr H CH.sub.2 CH.sub.2 Q-1.33 I.1-110 i-Pr H CH.sub.2 CH.sub.2 Q-1.91 I.1-111 i-Pr H CH.sub.2 CH.sub.2 Q-1.92 I.1-112 i-Pr H CH.sub.2 CH.sub.2 Q-1.93 I.1-113 i-Pr H CH.sub.2 CH.sub.2 Q-1.106 I.1-114 i-Pr H CH.sub.2 CH.sub.2 Q-1.107 I.1-115 i-Pr H CH.sub.2 CH.sub.2 Q-1.108 I.1-116 i-Pr H CH.sub.2 CH.sub.2 Q-1.121 I.1-117 i-Pr H CH.sub.2 CH.sub.2 Q-1.122 I.1-118 i-Pr H CH.sub.2 CH.sub.2 Q-1.123 I.1-119 i-Pr H CH.sub.2 CH.sub.2 Q-1.136 I.1-120 i-Pr H CH.sub.2 CH.sub.2 Q-1.137 I.1-121 i-Pr H CH.sub.2 CH.sub.2 Q-1.138 I.1-122 i-Pr H CH.sub.2 CH.sub.2 Q-1.166 I.1-123 i-Pr H CH.sub.2 CH.sub.2 Q-1.167 I.1-124 i-Pr H CH.sub.2 CH.sub.2 Q-1.168 I.1-125 i-Pr H CH.sub.2 CH.sub.2 Q-1.171 I.1-126 i-Pr H CH.sub.2 CH.sub.2 Q-1.172 I.1-127 i-Pr H CH.sub.2 CH.sub.2 Q-1.173 I.1-128 i-Pr H CH.sub.2 CH.sub.2 Q-1.176 I.1-129 i-Pr H CH.sub.2 CH.sub.2 Q-1.177 I.1-130 i-Pr H CH.sub.2 CH.sub.2 Q-1.178 I.1-131 i-Pr H CH.sub.2 CH.sub.2 Q-1.181 I.1-132 i-Pr H CH.sub.2 CH.sub.2 Q-1.182 I.1-133 i-Pr H CH.sub.2 CH.sub.2 Q-1.183 I.1-134 i-Pr H CH.sub.2 CH.sub.2 Q-1.201 I.1-135 i-Pr H CH.sub.2 CH.sub.2 Q-1.202 I.1-136 i-Pr H CH.sub.2 CH.sub.2 Q-1.203 I.1-137 i-Pr H CH.sub.2 CH.sub.2 Q-1.204 I.1-138 i-Pr H CH.sub.2 CH.sub.2 Q-1.205 I.1-139 i-Pr H CH.sub.2 CH.sub.2 Q-1.206 I.1-141 i-Pr H CH.sub.2 CH.sub.2 Q-1.207 I.1-142 i-Pr H CH.sub.2 CH.sub.2 Q-1.208 I.1-143 i-Pr H CH.sub.2 CH.sub.2 Q-1.209 I.1-144 i-Pr H CH.sub.2 CH.sub.2 Q-1.210 I.1-145 i-Pr H CH.sub.2 CH.sub.2 Q-1.211 I.1-146 i-Pr H CH.sub.2 CH.sub.2 Q-1.212 I.1-147 i-Pr H CH.sub.2 CH.sub.2 Q-1.213 I.1-148 i-Pr H CH.sub.2 CH.sub.2 Q-1.216 I.1-149 i-Pr H CH.sub.2 CH.sub.2 Q-1.217 I.1-150 i-Pr H CH.sub.2 CH.sub.2 Q-1.218 I.1-151 i-Pr H CH.sub.2 CH.sub.2 Q-1.246 I.1-152 i-Pr H CH.sub.2 CH.sub.2 Q-1.247 I.1-153 i-Pr H CH.sub.2 CH.sub.2 Q-1.248 I.1-154 i-Pr H CH.sub.2 CH.sub.2 Q-2.1 I.1-155 i-Pr H CH.sub.2 CH.sub.2 Q-2.2 I.1-156 i-Pr H CH.sub.2 CH.sub.2 Q-2.3 I.1-157 i-Pr H CH.sub.2 CH.sub.2 Q-2.5 I.1-158 i-Pr H CH.sub.2 CH.sub.2 Q-2.4 I.1-159 i-Pr H CH.sub.2 CH.sub.2 Q-2.7 I.1-160 i-Pr H CH.sub.2 CH.sub.2 Q-2.9 I.1-161 i-Pr H CH.sub.2 CH.sub.2 Q-2.12 I.1-162 i-Pr H CH.sub.2 CH.sub.2 Q-2.13 I.1-163 i-Pr H CH.sub.2 CH.sub.2 Q-2.14 I.1-164 i-Pr H CH.sub.2 CH.sub.2 Q-2.61 I.1-165 i-Pr H CH.sub.2 CH.sub.2 Q-2.62 I.1-166 i-Pr H CH.sub.2 CH.sub.2 Q-2.63 I.1-167 i-Pr H CH.sub.2 CH.sub.2 Q-2.64 I.1-168 i-Pr H CH.sub.2 CH.sub.2 Q-2.65 I.1-169 i-Pr H CH.sub.2 CH.sub.2 Q-2.67 I.1-170 i-Pr H CH.sub.2 CH.sub.2 Q-2.69 I.1-171 i-Pr H CH.sub.2 CH.sub.2 Q-2.72 I.1-172 i-Pr H CH.sub.2 CH.sub.2 Q-2.73 I.1-173 i-Pr H CH.sub.2 CH.sub.2 Q-2.74 I.1-174 i-Pr H CH.sub.2 CH.sub.2 Q-2.80 I.1-175 i-Pr H CH.sub.2 CH.sub.2 Q-2.105 I.1-176 i-Pr H CH.sub.2 CH.sub.2 Q-2.106 I.1-177 i-Pr H CH.sub.2 CH.sub.2 Q-2.108 I.1-178 i-Pr H CH.sub.2 CH.sub.2 Q-2.145 I.1-179 i-Pr H CH.sub.2 CH.sub.2 Q-2.146 I.1-180 i-Pr H CH.sub.2 CH.sub.2 Q-2.147 I.1-181 i-Pr H CH.sub.2 CH.sub.2 Q-2.161 I.1-182 i-Pr H CH.sub.2 CH.sub.2 Q-2.162 I.1-183 i-Pr H CH.sub.2 CH.sub.2 Q-2.163 I.1-184 i-Pr H CH.sub.2 CH.sub.2 Q-2.164 I.1-185 i-Pr H CH.sub.2 CH.sub.2 Q-2.165 I.1-186 i-Pr H CH.sub.2 CH.sub.2 Q-2.167 I.1-187 i-Pr H CH.sub.2 CH.sub.2 Q-2.168 I.1-188 i-Pr H CH.sub.2 CH.sub.2 Q-2.169 I.1-189 i-Pr H CH.sub.2 CH.sub.2 Q-2.172 I.1-190 i-Pr H CH.sub.2 CH.sub.2 Q-2.173 I.1-191 i-Pr H CH.sub.2 CH.sub.2 Q-2.174 I.1-192 i-Pr H CH.sub.2 CH.sub.2 Q-2.180 I.1-193 i-Pr H CH.sub.2 CH.sub.2 Q-2.185 I.1-194 i-Pr H CH.sub.2 CH.sub.2 Q-2.189 I.1-195 i-Pr H CH.sub.2 CH.sub.2 Q-2.190 I.1-196 i-Pr H CH.sub.2 CH.sub.2 Q-2.201 I.1-197 i-Pr H CH.sub.2 CH.sub.2 Q-2.202 I.1-198 i-Pr H CH.sub.2 CH.sub.2 Q-2.203 I.1-199 i-Pr H CH.sub.2 CH.sub.2 Q-2.204 I.1-200 i-Pr H CH.sub.2 CH.sub.2 Q-2.205 I.1-201 Ph H CH.sub.2 CH.sub.2 Q-1.1 I.1-202 Ph H CH.sub.2 CH.sub.2 Q-1.2 I.1-203 Ph H CH.sub.2 CH.sub.2 Q-1.3 I.1-204 Ph H CH.sub.2 CH.sub.2 Q-1.16 I.1-205 Ph H CH.sub.2 CH.sub.2 Q-1.17 I.1-206 Ph H CH.sub.2 CH.sub.2 Q-1.18 I.1-207 Ph H CH.sub.2 CH.sub.2 Q-1.31 I.1-208 Ph H CH.sub.2 CH.sub.2 Q-1.32 I.1-209 Ph H CH.sub.2 CH.sub.2 Q-1.33 I.1-210 Ph H CH.sub.2 CH.sub.2 Q-1.91 I.1-211 Ph H CH.sub.2 CH.sub.2 Q-1.92 I.1-212 Ph H CH.sub.2 CH.sub.2 Q-1.93 I.1-213 Ph H CH.sub.2 CH.sub.2 Q-1.106 I.1-214 Ph H CH.sub.2 CH.sub.2 Q-1.107 I.1-215 Ph H CH.sub.2 CH.sub.2 Q-1.108 I.1-216 Ph H CH.sub.2 CH.sub.2 Q-1.121 I.1-217 Ph H CH.sub.2 CH.sub.2 Q-1.122 I.1-218 Ph H CH.sub.2 CH.sub.2 Q-1.123 I.1-219 Ph H CH.sub.2 CH.sub.2 Q-1.136 I.1-220 Ph H CH.sub.2 CH.sub.2 Q-1.137 I.1-221 Ph H CH.sub.2 CH.sub.2 Q-1.138 I.1-222 Ph H CH.sub.2 CH.sub.2 Q-1.166 I.1-223 Ph H CH.sub.2 CH.sub.2 Q-1.167 I.1-224 Ph H CH.sub.2 CH.sub.2 Q-1.168 I.1-225 Ph H CH.sub.2 CH.sub.2 Q-1.171 I.1-226 Ph H CH.sub.2 CH.sub.2 Q-1.172 I.1-227 Ph H CH.sub.2 CH.sub.2 Q-1.173 I.1-228 Ph H CH.sub.2 CH.sub.2 Q-1.176 I.1-229 Ph H CH.sub.2 CH.sub.2 Q-1.177 I.1-230 Ph H CH.sub.2 CH.sub.2 Q-1.178 I.1-231 Ph H CH.sub.2 CH.sub.2 Q-1.181 I.1-232 Ph H CH.sub.2 CH.sub.2 Q-1.182 I.1-233 Ph H CH.sub.2 CH.sub.2 Q-1.183 I.1-234 Ph H CH.sub.2 CH.sub.2 Q-1.201 I.1-235 Ph H CH.sub.2 CH.sub.2 Q-1.202 I.1-236 Ph H CH.sub.2 CH.sub.2 Q-1.203 I.1-237 Ph H CH.sub.2 CH.sub.2 Q-1.204 I.1-238 Ph H CH.sub.2 CH.sub.2 Q-1.205 I.1-239 Ph H CH.sub.2 CH.sub.2 Q-1.206 I.1-241 Ph H CH.sub.2 CH.sub.2 Q-1.207 I.1-242 Ph H CH.sub.2 CH.sub.2 Q-1.208 I.1-243 Ph H CH.sub.2 CH.sub.2 Q-1.209 I.1-244 Ph H CH.sub.2 CH.sub.2 Q-1.210 I.1-245 Ph H CH.sub.2 CH.sub.2 Q-1.211 I.1-246 Ph H CH.sub.2 CH.sub.2 Q-1.212 I.1-247 Ph H CH.sub.2 CH.sub.2 Q-1.213 I.1-248 Ph H CH.sub.2 CH.sub.2 Q-1.216 I.1-249 Ph H CH.sub.2 CH.sub.2 Q-1.217 I.1-250 Ph H CH.sub.2 CH.sub.2 Q-1.218 I.1-251 Ph H CH.sub.2 CH.sub.2 Q-1.246 I.1-252 Ph H CH.sub.2 CH.sub.2 Q-1.247 I.1-253 Ph H CH.sub.2 CH.sub.2 Q-1.248 I.1-254 Ph H CH.sub.2 CH.sub.2 Q-2.1 I.1-255 Ph H CH.sub.2 CH.sub.2 Q-2.2 I.1-256 Ph H CH.sub.2 CH.sub.2 Q-2.3 I.1-257 Ph H CH.sub.2 CH.sub.2 Q-2.5 I.1-258 Ph H CH.sub.2 CH.sub.2 Q-2.4 I.1-259 Ph H CH.sub.2 CH.sub.2 Q-2.7 I.1-260 Ph H CH.sub.2 CH.sub.2 Q-2.9 I.1-261 Ph H CH.sub.2 CH.sub.2 Q-2.12 I.1-262 Ph H CH.sub.2 CH.sub.2 Q-2.13 I.1-263 Ph H CH.sub.2 CH.sub.2 Q-2.14 I.1-264 Ph H CH.sub.2 CH.sub.2 Q-2.61 I.1-265 Ph H CH.sub.2 CH.sub.2 Q-2.62 I.1-266 Ph H CH.sub.2 CH.sub.2 Q-2.63 I.1-267 Ph H CH.sub.2 CH.sub.2 Q-2.64 I.1-268 Ph H CH.sub.2 CH.sub.2 Q-2.65 I.1-269 Ph H CH.sub.2 CH.sub.2 Q-2.67 I.1-270 Ph H CH.sub.2 CH.sub.2 Q-2.69 I.1-271 Ph H CH.sub.2 CH.sub.2 Q-2.72 I.1-272 Ph H CH.sub.2 CH.sub.2 Q-2.73 I.1-273 Ph H CH.sub.2 CH.sub.2 Q-2.74 I.1-274 Ph H CH.sub.2 CH.sub.2 Q-2.80 I.1-275 Ph H CH.sub.2 CH.sub.2 Q-2.105 I.1-276 Ph H CH.sub.2 CH.sub.2 Q-2.106 I.1-277 Ph H CH.sub.2 CH.sub.2 Q-2.108 I.1-278 Ph H CH.sub.2 CH.sub.2 Q-2.145 I.1-279 Ph H CH.sub.2 CH.sub.2 Q-2.146 I.1-280 Ph H CH.sub.2 CH.sub.2 Q-2.147 I.1-281 Ph H CH.sub.2 CH.sub.2 Q-2.161 I.1-282 Ph H CH.sub.2 CH.sub.2 Q-2.162 I.1-283 Ph H CH.sub.2 CH.sub.2 Q-2.163 I.1-284 Ph H CH.sub.2 CH.sub.2 Q-2.164 I.1-285 Ph H CH.sub.2 CH.sub.2 Q-2.165 I.1-286 Ph H CH.sub.2 CH.sub.2 Q-2.167 I.1-287 Ph H CH.sub.2 CH.sub.2 Q-2.168 I.1-288 Ph H CH.sub.2 CH.sub.2 Q-2.169 I.1-289 Ph H CH.sub.2 CH.sub.2 Q-2.172 I.1-290 Ph H CH.sub.2 CH.sub.2 Q-2.173 I.1-291 Ph H CH.sub.2 CH.sub.2 Q-2.174 I.1-292 Ph H CH.sub.2 CH.sub.2 Q-2.180 I.1-293 Ph H CH.sub.2 CH.sub.2 Q-2.185 I.1-294 Ph H CH.sub.2 CH.sub.2 Q-2.189 I.1-295 Ph H CH.sub.2 CH.sub.2 Q-2.190 I.1-296 Ph H CH.sub.2 CH.sub.2 Q-2.201 I.1-297 Ph H CH.sub.2 CH.sub.2 Q-2.202 I.1-298 Ph H CH.sub.2 CH.sub.2 Q-2.203 I.1-299 Ph H CH.sub.2 CH.sub.2 Q-2.204 I.1-300 Ph H CH.sub.2 CH.sub.2 Q-2.205 I.1-301 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-302 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-303 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-304 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-305 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-306 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-307 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-308 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-309 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-310 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-311 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-312 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-313 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-314 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-315 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-316 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-317 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-318 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-319 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-320 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-321 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-322 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-323 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-324 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-325 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-326 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-327 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-328 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-329 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-330 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-331 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-332 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-333 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-334 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-335 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-336 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-337 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-338 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-339 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-340 CH.sub.3 C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-341 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-342 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-343 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-344 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-345 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-346 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-347 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-348 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-349 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-350 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-351 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-352 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-353 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-354 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-355 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-356 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-357 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-358 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-359 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-360 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-361 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-362 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-363 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-364 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-365 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-366 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-367 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-368 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-369 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-370 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-371 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-372 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-373 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-374 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-375 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-376 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-377 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-378 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-379 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-380 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-381 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-382 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-383 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-384 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-385 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-386 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-387 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-388 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-389 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-390 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-391 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-392 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-393 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-394 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-395 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-396 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-397 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-398 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-399 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-400 Ph C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-401 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-402 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-403 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-404 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-405 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-406 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-407 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-408 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-409 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-410 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-411 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-412 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-413 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-414 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-415 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-416 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-417 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-418 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-419 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-420 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-421 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-422 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-423 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-424 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-425 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-426 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-427 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-428 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-429 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-430 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-431 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-432 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-433 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-434 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-435 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-436 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-437 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-438 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-439 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-440 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-441 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-442 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-443 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-444 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-445 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-446 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-447 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-448 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-449 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-450 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-451 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-452 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-453 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-454 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-455 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-456 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-457 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-458 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-459 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-460 i-Pr C()CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-461 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.1-462 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.1-463 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.1-464 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.1-465 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.1-466 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.1-467 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.1-468 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.1-469 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.1-470 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.1-471 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.1-472 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.1-473 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.1-474 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.1-475 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.1-476 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.1-477 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.1-478 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.1-479 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.1-480 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.1-481 i-Pr CH.sub.3 CHF CH.sub.2 Q-1.3 I.1-482 i-Pr CH.sub.3 CHF CH.sub.2 Q-1.168 I.1-483 i-Pr CH.sub.3 CHF CH.sub.2 Q-1.203 I.1-484 Ph CH.sub.3 CHF CH.sub.2 Q-1.3 I.1-485 Ph CH.sub.3 CHF CH.sub.2 Q-1.168 I.1-486 Ph CH.sub.3 CHF CH.sub.2 Q-1.203 I.1-487 CH.sub.3 CH.sub.3 CHF CH.sub.2 Q-1.3 I.1-488 CH.sub.3 CH.sub.3 CHF CH.sub.2 Q-1.168 I.1-489 CH.sub.3 CH.sub.3 CHF CH.sub.2 Q-1.203 I.1-490 i-Pr CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.3 I.1-491 i-Pr CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.168 I.1-492 i-Pr CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.203 I.1-493 Ph CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.3 I.1-494 Ph CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.168 I.1-495 Ph CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.203 I.1-496 CH.sub.3 CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.3 I.1-497 CH.sub.3 CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.168 I.1-498 CH.sub.3 CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.203 I.1-499 i-Pr CH.sub.3 CH(i-Pr) CH.sub.2 Q-1.168 I.1-500 i-Pr CH.sub.3 CH(i-Pr) CH.sub.2 Q-1.203 I.1-501 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.1 I.1-502 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.2 I.1-503 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.3 I.1-504 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.16 I.1-505 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.17 I.1-506 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.18 I.1-507 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.31 I.1-508 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.32 I.1-509 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.33 I.1-510 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.91 I.1-511 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.92 I.1-512 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.93 I.1-513 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.106 I.1-514 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.107 I.1-515 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.108 I.1-516 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.121 I.1-517 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.122 I.1-518 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.123 I.1-519 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.136 I.1-520 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.137 I.1-521 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.138 I.1-522 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.166 I.1-523 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.167 I.1-524 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.168 I.1-525 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.171 I.1-526 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.172 I.1-527 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.173 I.1-528 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.176 I.1-529 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.177 I.1-530 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.178 I.1-531 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.181 I.1-532 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.182 I.1-533 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.183 I.1-534 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.201 I.1-535 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.202 I.1-536 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.203 I.1-537 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.204 I.1-538 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.205 I.1-539 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.206 I.1-541 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.207 I.1-542 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.208 I.1-543 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.209 I.1-544 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.210 I.1-545 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.211 I.1-546 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.212 I.1-547 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.213 I.1-548 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.216 I.1-549 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.217 I.1-550 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.218 I.1-551 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.246 I.1-552 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.247 I.1-553 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.248 I.1-554 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.1 I.1-555 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.2 I.1-556 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.3 I.1-557 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.5 I.1-558 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.4 I.1-559 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.7 I.1-560 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.9 I.1-561 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.12 I.1-562 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.13 I.1-563 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.14 I.1-564 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.61 I.1-565 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.62 I.1-566 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.63 I.1-567 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.64 I.1-568 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.65 I.1-569 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.67 I.1-570 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.69 I.1-571 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.72 I.1-572 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.73 I.1-573 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.74 I.1-574 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.80 I.1-575 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.105 I.1-576 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.106 I.1-577 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.108 I.1-578 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.145 I.1-579 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.146 I.1-580 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.147 I.1-581 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.161 I.1-582 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.162 I.1-583 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.163 I.1-584 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.164 I.1-585 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.165 I.1-586 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.167 I.1-587 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.168 I.1-588 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.169 I.1-589 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.172 I.1-590 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.173 I.1-591 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.174 I.1-592 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.180 I.1-593 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.185 I.1-594 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.189 I.1-595 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.190 I.1-596 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.201 I.1-597 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.202 I.1-598 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.203 I.1-599 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.204 I.1-600 4-F-Ph H CH.sub.2 CH.sub.2 Q-2.205 I.1-601 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.6 I.1-602 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.10 I.1-603 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.11 I.1-604 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.141 I.1-605 i-Pr H CH.sub.2 CH.sub.2 Q-1.6 I.1-606 i-Pr H CH.sub.2 CH.sub.2 Q-1.10 I.1-607 i-Pr H CH.sub.2 CH.sub.2 Q-1.11 I.1-608 i-Pr H CH.sub.2 CH.sub.2 Q-1.141 I.1-609 Ph H CH.sub.2 CH.sub.2 Q-1.6 I.1-610 Ph H CH.sub.2 CH.sub.2 Q-1.10 I.1-611 Ph H CH.sub.2 CH.sub.2 Q-1.11 I.1-612 Ph H CH.sub.2 CH.sub.2 Q-1.141 I.1-613 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.6 I.1-614 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.10 I.1-615 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.11 I.1-616 4-F-Ph H CH.sub.2 CH.sub.2 Q-1.141 I.1-617 c-Pr H CH.sub.2 CH.sub.2 Q-1.1 I.1-618 c-Pr H CH.sub.2 CH.sub.2 Q-1.2 I.1-619 c-Pr H CH.sub.2 CH.sub.2 Q-1.3 I.1-620 c-Pr H CH.sub.2 CH.sub.2 Q-1.6 I.1-621 c-Pr H CH.sub.2 CH.sub.2 Q-1.10 I.1-622 c-Pr H CH.sub.2 CH.sub.2 Q-1.11 I.1-623 c-Pr H CH.sub.2 CH.sub.2 Q-1.16 I.1-624 c-Pr H CH.sub.2 CH.sub.2 Q-1.17 I.1-625 c-Pr H CH.sub.2 CH.sub.2 Q-1.18 I.1-626 c-Pr H CH.sub.2 CH.sub.2 Q-1.21 I.1-627 c-Pr H CH.sub.2 CH.sub.2 Q-1.91 I.1-628 c-Pr H CH.sub.2 CH.sub.2 Q-1.92 I.1-629 c-Pr H CH.sub.2 CH.sub.2 Q-1.93 I.1-630 c-Pr H CH.sub.2 CH.sub.2 Q-1.96 I.1-631 c-Pr H CH.sub.2 CH.sub.2 Q-1.136 I.1-632 c-Pr H CH.sub.2 CH.sub.2 Q-1.137 I.1-633 c-Pr H CH.sub.2 CH.sub.2 Q-1.138 I.1-634 c-Pr H CH.sub.2 CH.sub.2 Q-1.166 I.1-635 c-Pr H CH.sub.2 CH.sub.2 Q-1.167 I.1-636 c-Pr H CH.sub.2 CH.sub.2 Q-1.168 I.1-637 c-Pr H CH.sub.2 CH.sub.2 Q-1.171 I.1-638 c-Pr H CH.sub.2 CH.sub.2 Q-1.172 I.1-639 c-Pr H CH.sub.2 CH.sub.2 Q-1.173 I.1-640 c-Pr H CH.sub.2 CH.sub.2 Q-1.201 I.1-641 c-Pr H CH.sub.2 CH.sub.2 Q-1.202 I.1-642 c-Pr H CH.sub.2 CH.sub.2 Q-1.203 I.1-643 c-Pr H CH.sub.2 CH.sub.2 Q-1.206 I.1-644 c-Pr H CH.sub.2 CH.sub.2 Q-1.207 I.1-645 c-Pr H CH.sub.2 CH.sub.2 Q-1.210 I.1-646 c-Pr H CH.sub.2 CH.sub.2 Q-1.211 I.1-647 c-Bu H CH.sub.2 CH.sub.2 Q-1.1 I.1-648 c-Bu H CH.sub.2 CH.sub.2 Q-1.2 I.1-649 c-Bu H CH.sub.2 CH.sub.2 Q-1.3 I.1-650 c-Bu H CH.sub.2 CH.sub.2 Q-1.6 I.1-651 c-Bu H CH.sub.2 CH.sub.2 Q-1.10 I.1-652 c-Bu H CH.sub.2 CH.sub.2 Q-1.11 I.1-653 c-Bu H CH.sub.2 CH.sub.2 Q-1.16 I.1-654 c-Bu H CH.sub.2 CH.sub.2 Q-1.17 I.1-655 c-Bu H CH.sub.2 CH.sub.2 Q-1.18 I.1-656 c-Bu H CH.sub.2 CH.sub.2 Q-1.21 I.1-657 c-Bu H CH.sub.2 CH.sub.2 Q-1.91 I.1-658 c-Bu H CH.sub.2 CH.sub.2 Q-1.92 I.1-659 c-Bu H CH.sub.2 CH.sub.2 Q-1.93 I.1-660 c-Bu H CH.sub.2 CH.sub.2 Q-1.96 I.1-661 c-Bu H CH.sub.2 CH.sub.2 Q-1.136 I.1-662 c-Bu H CH.sub.2 CH.sub.2 Q-1.137 I.1-663 c-Bu H CH.sub.2 CH.sub.2 Q-1.138 I.1-664 c-Bu H CH.sub.2 CH.sub.2 Q-1.166 I.1-665 c-Bu H CH.sub.2 CH.sub.2 Q-1.167 I.1-666 c-Bu H CH.sub.2 CH.sub.2 Q-1.168 I.1-667 c-Bu H CH.sub.2 CH.sub.2 Q-1.171 I.1-668 c-Bu H CH.sub.2 CH.sub.2 Q-1.172 I.1-669 c-Bu H CH.sub.2 CH.sub.2 Q-1.173 I.1-670 c-Bu H CH.sub.2 CH.sub.2 Q-1.201 I.1-671 c-Bu H CH.sub.2 CH.sub.2 Q-1.202 I.1-672 c-Bu H CH.sub.2 CH.sub.2 Q-1.203 I.1-673 c-Bu H CH.sub.2 CH.sub.2 Q-1.206 I.1-674 c-Bu H CH.sub.2 CH.sub.2 Q-1.207 I.1-675 c-Bu H CH.sub.2 CH.sub.2 Q-1.210 I.1-676 c-Bu H CH.sub.2 CH.sub.2 Q-1.211 I.1-677 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.1 I.1-678 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.2 I.1-679 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.3 I.1-680 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.6 I.1-681 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.10 I.1-682 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.11 I.1-683 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.16 I.1-684 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.17 I.1-685 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.18 I.1-686 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.21 I.1-687 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.91 I.1-688 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.92 I.1-689 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.93 I.1-690 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.96 I.1-691 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.136 I.1-692 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.137 I.1-693 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.138 I.1-694 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.166 I.1-695 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.167 I.1-696 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.168 I.1-697 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.171 I.1-698 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.172 I.1-699 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.173 I.1-700 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.201 I.1-701 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.202 I.1-702 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.203 I.1-703 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.206 I.1-704 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.207 I.1-705 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.210 I.1-706 c-Hexyl H CH.sub.2 CH.sub.2 Q-1.211 I.1-707 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.1 I.1-708 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.2 I.1-709 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.3 I.1-710 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.6 I.1-711 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.10 I.1-712 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.11 I.1-713 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.16 I.1-714 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.17 I.1-715 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.18 I.1-716 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.21 I.1-717 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.91 I.1-718 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.92 I.1-719 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.93 I.1-720 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.96 I.1-721 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.136 I.1-722 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.137 I.1-723 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.138 I.1-724 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.166 I.1-725 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.167 I.1-726 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.168 I.1-727 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.171 I.1-728 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.172 I.1-729 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.173 I.1-730 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.201 I.1-731 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.202 I.1-732 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.203 I.1-733 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.206 I.1-734 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.207 I.1-735 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.210 I.1-736 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.211 I.1-737 Adamantyl H CH.sub.2 CH.sub.2 Q-1.1 I.1-738 Adamantyl H CH.sub.2 CH.sub.2 Q-1.2 I.1-739 Adamantyl H CH.sub.2 CH.sub.2 Q-1.3 I.1-740 Adamantyl H CH.sub.2 CH.sub.2 Q-1.6 I.1-741 Adamantyl H CH.sub.2 CH.sub.2 Q-1.10 I.1-742 Adamantyl H CH.sub.2 CH.sub.2 Q-1.11 I.1-743 Adamantyl H CH.sub.2 CH.sub.2 Q-1.16 I.1-744 Adamantyl H CH.sub.2 CH.sub.2 Q-1.17 I.1-745 Adamantyl H CH.sub.2 CH.sub.2 Q-1.18 I.1-746 Adamantyl H CH.sub.2 CH.sub.2 Q-1.21 I.1-747 Adamantyl H CH.sub.2 CH.sub.2 Q-1.91 I.1-748 Adamantyl H CH.sub.2 CH.sub.2 Q-1.92 I.1-749 Adamantyl H CH.sub.2 CH.sub.2 Q-1.93 I.1-750 Adamantyl H CH.sub.2 CH.sub.2 Q-1.96 I.1-751 Adamantyl H CH.sub.2 CH.sub.2 Q-1.136 I.1-752 Adamantyl H CH.sub.2 CH.sub.2 Q-1.137 I.1-753 Adamantyl H CH.sub.2 CH.sub.2 Q-1.138 I.1-754 Adamantyl H CH.sub.2 CH.sub.2 Q-1.166 I.1-755 Adamantyl H CH.sub.2 CH.sub.2 Q-1.167 I.1-756 Adamantyl H CH.sub.2 CH.sub.2 Q-1.168 I.1-757 Adamantyl H CH.sub.2 CH.sub.2 Q-1.171 I.1-758 Adamantyl H CH.sub.2 CH.sub.2 Q-1.172 I.1-759 Adamantyl H CH.sub.2 CH.sub.2 Q-1.173 I.1-760 Adamantyl H CH.sub.2 CH.sub.2 Q-1.201 I.1-761 Adamantyl H CH.sub.2 CH.sub.2 Q-1.202 I.1-762 Adamantyl H CH.sub.2 CH.sub.2 Q-1.203 I.1-763 Adamantyl H CH.sub.2 CH.sub.2 Q-1.206 I.1-764 Adamantyl H CH.sub.2 CH.sub.2 Q-1.207 I.1-765 Adamantyl H CH.sub.2 CH.sub.2 Q-1.210 I.1-766 Adamantyl H CH.sub.2 CH.sub.2 Q-1.211 I.1-767 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.1 I.1-768 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.2 I.1-769 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.3 I.1-770 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.6 I.1-771 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.10 I.1-772 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.11 I.1-773 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.16 I.1-774 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.17 I.1-775 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.18 I.1-776 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.21 I.1-777 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.91 I.1-778 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.92 I.1-779 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.93 I.1-780 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.96 I.1-781 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.136 I.1-782 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.137 I.1-783 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.138 I.1-784 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.166 I.1-785 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.167 I.1-786 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.168 I.1-787 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.171 I.1-788 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.172 I.1-789 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.173 I.1-790 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.201 I.1-791 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.202 I.1-792 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.203 I.1-793 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.206 I.1-794 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.207 I.1-795 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.210 I.1-796 3-F-Ph H CH.sub.2 CH.sub.2 Q-1.211 I.1-797 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.1 I.1-798 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.2 I.1-799 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.3 I.1-800 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.6 I.1-801 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.10 I.1-802 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.11 I.1-803 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.16 I.1-804 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.17 I.1-805 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.18 I.1-806 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.21 I.1-807 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.91 I.1-808 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.92 I.1-809 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.93 I.1-810 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.96 I.1-811 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.136 I.1-812 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.137 I.1-813 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.138 I.1-814 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.166 I.1-815 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.167 I.1-816 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.168 I.1-817 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.171 I.1-818 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.172 I.1-819 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.173 I.1-820 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.201 I.1-821 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.202 I.1-822 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.203 I.1-823 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.206 I.1-824 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.207 I.1-825 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.210 I.1-826 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.211 I.1-827 c-Pent H CH.sub.2 CH.sub.2 Q-1.1 I.1-828 c-Pent H CH.sub.2 CH.sub.2 Q-1.2 I.1-829 c-Pent H CH.sub.2 CH.sub.2 Q-1.3 I.1-830 c-Pent H CH.sub.2 CH.sub.2 Q-1.6 I.1-831 c-Pent H CH.sub.2 CH.sub.2 Q-1.10 I.1-832 c-Pent H CH.sub.2 CH.sub.2 Q-1.11 I.1-833 c-Pent H CH.sub.2 CH.sub.2 Q-1.16 I.1-834 c-Pent H CH.sub.2 CH.sub.2 Q-1.17 I.1-835 c-Pent H CH.sub.2 CH.sub.2 Q-1.18 I.1-836 c-Pent H CH.sub.2 CH.sub.2 Q-1.21 I.1-837 c-Pent H CH.sub.2 CH.sub.2 Q-1.91 I.1-838 c-Pent H CH.sub.2 CH.sub.2 Q-1.92 I.1-839 c-Pent H CH.sub.2 CH.sub.2 Q-1.93 I.1-840 c-Pent H CH.sub.2 CH.sub.2 Q-1.96 I.1-841 c-Pent H CH.sub.2 CH.sub.2 Q-1.136 I.1-842 c-Pent H CH.sub.2 CH.sub.2 Q-1.137 I.1-843 c-Pent H CH.sub.2 CH.sub.2 Q-1.138 I.1-844 c-Pent H CH.sub.2 CH.sub.2 Q-1.166 I.1-845 c-Pent H CH.sub.2 CH.sub.2 Q-1.167 I.1-846 c-Pent H CH.sub.2 CH.sub.2 Q-1.168 I.1-847 c-Pent H CH.sub.2 CH.sub.2 Q-1.171 I.1-848 c-Pent H CH.sub.2 CH.sub.2 Q-1.172 I.1-849 c-Pent H CH.sub.2 CH.sub.2 Q-1.173 I.1-850 c-Pent H CH.sub.2 CH.sub.2 Q-1.201 I.1-851 c-Pent H CH.sub.2 CH.sub.2 Q-1.202 I.1-852 c-Pent H CH.sub.2 CH.sub.2 Q-1.203 I.1-853 c-Pent H CH.sub.2 CH.sub.2 Q-1.206 I.1-854 c-Pent H CH.sub.2 CH.sub.2 Q-1.207 I.1-855 c-Pent H CH.sub.2 CH.sub.2 Q-1.210 I.1-856 c-Pent H CH.sub.2 CH.sub.2 Q-1.211 I.1-857 t-Bu H CH.sub.2 CH.sub.2 Q-1.1 I.1-858 t-Bu H CH.sub.2 CH.sub.2 Q-1.2 I.1-859 t-Bu H CH.sub.2 CH.sub.2 Q-1.3 I.1-860 t-Bu H CH.sub.2 CH.sub.2 Q-1.6 I.1-861 t-Bu H CH.sub.2 CH.sub.2 Q-1.10 I.1-862 t-Bu H CH.sub.2 CH.sub.2 Q-1.11 I.1-863 t-Bu H CH.sub.2 CH.sub.2 Q-1.16 I.1-864 t-Bu H CH.sub.2 CH.sub.2 Q-1.17 I.1-865 t-Bu H CH.sub.2 CH.sub.2 Q-1.18 I.1-866 t-Bu H CH.sub.2 CH.sub.2 Q-1.21 I.1-867 t-Bu H CH.sub.2 CH.sub.2 Q-1.91 I.1-868 t-Bu H CH.sub.2 CH.sub.2 Q-1.92 I.1-869 t-Bu H CH.sub.2 CH.sub.2 Q-1.93 I.1-870 t-Bu H CH.sub.2 CH.sub.2 Q-1.96 I.1-871 t-Bu H CH.sub.2 CH.sub.2 Q-1.136 I.1-872 t-Bu H CH.sub.2 CH.sub.2 Q-1.137 I.1-873 t-Bu H CH.sub.2 CH.sub.2 Q-1.138 I.1-874 t-Bu H CH.sub.2 CH.sub.2 Q-1.166 I.1-875 t-Bu H CH.sub.2 CH.sub.2 Q-1.167 I.1-876 t-Bu H CH.sub.2 CH.sub.2 Q-1.168 I.1-877 t-Bu H CH.sub.2 CH.sub.2 Q-1.171 I.1-878 t-Bu H CH.sub.2 CH.sub.2 Q-1.172 I.1-879 t-Bu H CH.sub.2 CH.sub.2 Q-1.173 I.1-880 t-Bu H CH.sub.2 CH.sub.2 Q-1.201 I.1-881 t-Bu H CH.sub.2 CH.sub.2 Q-1.202 I.1-882 t-Bu H CH.sub.2 CH.sub.2 Q-1.203 I.1-883 t-Bu H CH.sub.2 CH.sub.2 Q-1.206 I.1-884 t-Bu H CH.sub.2 CH.sub.2 Q-1.207 I.1-885 t-Bu H CH.sub.2 CH.sub.2 Q-1.210 I.1-886 t-Bu H CH.sub.2 CH.sub.2 Q-1.211 I.1-887 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.141 I.1-888 4-CH.sub.3-Ph H CH.sub.2 CH.sub.2 Q-1.141 I.1-889 t-Bu H CH.sub.2 CH.sub.2 Q-1.141 I.1-890 c-Pent H CH.sub.2 CH.sub.2 Q-1.141 I.1-891 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.1 I.1-892 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.2 I.1-893 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.3 I.1-894 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.6 I.1-895 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.10 I.1-896 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.11 I.1-897 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.16 I.1-898 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.17 I.1-899 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.18 I.1-900 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.21 I.1-901 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.91 I.1-902 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.92 I.1-903 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.93 I.1-904 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.96 I.1-905 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.136 I.1-906 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.137 I.1-907 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.138 I.1-908 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.166 I.1-909 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.167 I.1-910 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.168 I.1-911 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.171 I.1-912 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.172 I.1-913 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.173 I.1-914 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.201 I.1-915 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.202 I.1-916 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.203 I.1-917 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.206 I.1-918 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.207 I.1-919 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.210 I.1-920 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.211 I.1-921 4-Cl-Ph H CH.sub.2 CH.sub.2 Q-1.141

TABLE-US-00003 TABLE 2 (I) [00569] No. R.sup.1 R.sup.2 A.sup.1 A.sup.2 Q I.2-1 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.1 I.2-2 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.2 I.2-3 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.3 I.2-4 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.16 I.2-5 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.17 I.2-6 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.18 I.2-7 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.31 I.2-8 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.32 I.2-9 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.33 I.2-10 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.91 I.2-11 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.92 I.2-12 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.93 I.2-13 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.106 I.2-14 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.107 I.2-15 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.108 I.2-16 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.121 I.2-17 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.122 I.2-18 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.123 I.2-19 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.136 I.2-20 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.137 I.2-21 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.138 I.2-22 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.166 I.2-23 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.167 I.2-24 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.168 I.2-25 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.171 I.2-26 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.172 I.2-27 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.173 I.2-28 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.176 I.2-29 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.177 I.2-30 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.178 I.2-31 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.181 I.2-32 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.182 I.2-33 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.183 I.2-34 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.201 I.2-35 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.202 I.2-36 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.203 I.2-37 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.204 I.2-38 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.205 I.2-39 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.206 I.2-41 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.207 I.2-42 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.208 I.2-43 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.209 I.2-44 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.210 I.2-45 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.211 I.2-46 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.212 I.2-47 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.213 I.2-48 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.216 I.2-49 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.217 I.2-50 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.218 I.2-51 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.246 I.2-52 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.247 I.2-53 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.248 I.2-54 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.1 I.2-55 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.2 I.2-56 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.3 I.2-57 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.5 I.2-58 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.4 I.2-59 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.7 I.2-60 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.9 I.2-61 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.12 I.2-62 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.13 I.2-63 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.14 I.2-64 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.61 I.2-65 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.62 I.2-66 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.63 I.2-67 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.64 I.2-68 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.65 I.2-69 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.67 I.2-70 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.69 I.2-71 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.72 I.2-72 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.73 I.2-73 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.74 I.2-74 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.80 I.2-75 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.105 I.2-76 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.106 I.2-77 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.108 I.2-78 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.145 I.2-79 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.146 I.2-80 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.147 I.2-81 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.161 I.2-82 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.162 I.2-83 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.163 I.2-84 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.164 I.2-85 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.165 I.2-86 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.167 I.2-87 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.168 I.2-88 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.169 I.2-89 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.172 I.2-90 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.173 I.2-91 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.174 I.2-92 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.180 I.2-93 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.185 I.2-94 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.189 I.2-95 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.190 I.2-96 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.201 I.2-97 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.202 I.2-98 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.203 I.2-99 CH.sub.3 H CH.sub.2 CH.sub.2 Q-2.204 I.2-100 i-Pr H CH.sub.2 CH.sub.2 Q-1.10 I.2-101 i-Pr H CH.sub.2 CH.sub.2 Q-1.1 I.2-102 i-Pr H CH.sub.2 CH.sub.2 Q-1.2 I.2-103 i-Pr H CH.sub.2 CH.sub.2 Q-1.3 I.2-104 i-Pr H CH.sub.2 CH.sub.2 Q-1.16 I.2-105 i-Pr H CH.sub.2 CH.sub.2 Q-1.17 I.2-106 i-Pr H CH.sub.2 CH.sub.2 Q-1.18 I.2-107 i-Pr H CH.sub.2 CH.sub.2 Q-1.31 I.2-108 i-Pr H CH.sub.2 CH.sub.2 Q-1.32 I.2-109 i-Pr H CH.sub.2 CH.sub.2 Q-1.33 I.2-110 i-Pr H CH.sub.2 CH.sub.2 Q-1.91 I.2-111 i-Pr H CH.sub.2 CH.sub.2 Q-1.92 I.2-112 i-Pr H CH.sub.2 CH.sub.2 Q-1.93 I.2-113 i-Pr H CH.sub.2 CH.sub.2 Q-1.106 I.2-114 i-Pr H CH.sub.2 CH.sub.2 Q-1.107 I.2-115 i-Pr H CH.sub.2 CH.sub.2 Q-1.108 I.2-116 i-Pr H CH.sub.2 CH.sub.2 Q-1.121 I.2-117 i-Pr H CH.sub.2 CH.sub.2 Q-1.122 I.2-118 i-Pr H CH.sub.2 CH.sub.2 Q-1.123 I.2-119 i-Pr H CH.sub.2 CH.sub.2 Q-1.136 I.2-120 i-Pr H CH.sub.2 CH.sub.2 Q-1.137 I.2-121 i-Pr H CH.sub.2 CH.sub.2 Q-1.138 I.2-122 i-Pr H CH.sub.2 CH.sub.2 Q-1.166 I.2-123 i-Pr H CH.sub.2 CH.sub.2 Q-1.167 I.2-124 i-Pr H CH.sub.2 CH.sub.2 Q-1.168 I.2-125 i-Pr H CH.sub.2 CH.sub.2 Q-1.171 I.2-126 i-Pr H CH.sub.2 CH.sub.2 Q-1.172 I.2-127 i-Pr H CH.sub.2 CH.sub.2 Q-1.173 I.2-128 i-Pr H CH.sub.2 CH.sub.2 Q-1.176 I.2-129 i-Pr H CH.sub.2 CH.sub.2 Q-1.177 I.2-130 i-Pr H CH.sub.2 CH.sub.2 Q-1.178 I.2-131 i-Pr H CH.sub.2 CH.sub.2 Q-1.181 I.2-132 i-Pr H CH.sub.2 CH.sub.2 Q-1.182 I.2-133 i-Pr H CH.sub.2 CH.sub.2 Q-1.183 I.2-134 i-Pr H CH.sub.2 CH.sub.2 Q-1.201 I.2-135 i-Pr H CH.sub.2 CH.sub.2 Q-1.202 I.2-136 i-Pr H CH.sub.2 CH.sub.2 Q-1.203 I.2-137 i-Pr H CH.sub.2 CH.sub.2 Q-1.204 I.2-138 i-Pr H CH.sub.2 CH.sub.2 Q-1.205 I.2-139 i-Pr H CH.sub.2 CH.sub.2 Q-1.206 I.2-141 i-Pr H CH.sub.2 CH.sub.2 Q-1.207 I.2-142 i-Pr H CH.sub.2 CH.sub.2 Q-1.208 I.2-143 i-Pr H CH.sub.2 CH.sub.2 Q-1.209 I.2-144 i-Pr H CH.sub.2 CH.sub.2 Q-1.210 I.2-145 i-Pr H CH.sub.2 CH.sub.2 Q-1.211 I.2-146 i-Pr H CH.sub.2 CH.sub.2 Q-1.212 I.2-147 i-Pr H CH.sub.2 CH.sub.2 Q-1.213 I.2-148 i-Pr H CH.sub.2 CH.sub.2 Q-1.216 I.2-149 i-Pr H CH.sub.2 CH.sub.2 Q-1.217 I.2-150 i-Pr H CH.sub.2 CH.sub.2 Q-1.218 I.2-151 i-Pr H CH.sub.2 CH.sub.2 Q-1.246 I.2-152 i-Pr H CH.sub.2 CH.sub.2 Q-1.247 I.2-153 i-Pr H CH.sub.2 CH.sub.2 Q-1.248 I.2-154 i-Pr H CH.sub.2 CH.sub.2 Q-2.1 I.2-155 i-Pr H CH.sub.2 CH.sub.2 Q-2.2 I.2-156 i-Pr H CH.sub.2 CH.sub.2 Q-2.3 I.2-157 i-Pr H CH.sub.2 CH.sub.2 Q-2.5 I.2-158 i-Pr H CH.sub.2 CH.sub.2 Q-2.4 I.2-159 i-Pr H CH.sub.2 CH.sub.2 Q-2.7 I.2-160 i-Pr H CH.sub.2 CH.sub.2 Q-2.9 I.2-161 i-Pr H CH.sub.2 CH.sub.2 Q-2.12 I.2-162 i-Pr H CH.sub.2 CH.sub.2 Q-2.13 I.2-163 i-Pr H CH.sub.2 CH.sub.2 Q-2.14 I.2-164 i-Pr H CH.sub.2 CH.sub.2 Q-2.61 I.2-165 i-Pr H CH.sub.2 CH.sub.2 Q-2.62 I.2-166 i-Pr H CH.sub.2 CH.sub.2 Q-2.63 I.2-167 i-Pr H CH.sub.2 CH.sub.2 Q-2.64 I.2-168 i-Pr H CH.sub.2 CH.sub.2 Q-2.65 I.2-169 i-Pr H CH.sub.2 CH.sub.2 Q-2.67 I.2-170 i-Pr H CH.sub.2 CH.sub.2 Q-2.69 I.2-171 i-Pr H CH.sub.2 CH.sub.2 Q-2.72 I.2-172 i-Pr H CH.sub.2 CH.sub.2 Q-2.73 I.2-173 i-Pr H CH.sub.2 CH.sub.2 Q-2.74 I.2-174 i-Pr H CH.sub.2 CH.sub.2 Q-2.80 I.2-175 i-Pr H CH.sub.2 CH.sub.2 Q-2.105 I.2-176 i-Pr H CH.sub.2 CH.sub.2 Q-2.106 I.2-177 i-Pr H CH.sub.2 CH.sub.2 Q-2.108 I.2-178 i-Pr H CH.sub.2 CH.sub.2 Q-2.145 I.2-179 i-Pr H CH.sub.2 CH.sub.2 Q-2.146 I.2-180 i-Pr H CH.sub.2 CH.sub.2 Q-2.147 I.2-181 i-Pr H CH.sub.2 CH.sub.2 Q-2.161 I.2-182 i-Pr H CH.sub.2 CH.sub.2 Q-2.162 I.2-183 i-Pr H CH.sub.2 CH.sub.2 Q-2.163 I.2-184 i-Pr H CH.sub.2 CH.sub.2 Q-2.164 I.2-185 i-Pr H CH.sub.2 CH.sub.2 Q-2.165 I.2-186 i-Pr H CH.sub.2 CH.sub.2 Q-2.167 I.2-187 i-Pr H CH.sub.2 CH.sub.2 Q-2.168 I.2-188 i-Pr H CH.sub.2 CH.sub.2 Q-2.169 I.2-189 i-Pr H CH.sub.2 CH.sub.2 Q-2.172 I.2-190 i-Pr H CH.sub.2 CH.sub.2 Q-2.173 I.2-191 i-Pr H CH.sub.2 CH.sub.2 Q-2.174 I.2-192 i-Pr H CH.sub.2 CH.sub.2 Q-2.180 I.2-193 i-Pr H CH.sub.2 CH.sub.2 Q-2.185 I.2-194 i-Pr H CH.sub.2 CH.sub.2 Q-2.189 I.2-195 i-Pr H CH.sub.2 CH.sub.2 Q-2.190 I.2-196 i-Pr H CH.sub.2 CH.sub.2 Q-2.201 I.2-197 i-Pr H CH.sub.2 CH.sub.2 Q-2.202 I.2-198 i-Pr H CH.sub.2 CH.sub.2 Q-2.203 I.2-199 i-Pr H CH.sub.2 CH.sub.2 Q-2.204 I.2-200 i-Pr H CH.sub.2 CH.sub.2 Q-2.205 I.2-201 Ph H CH.sub.2 CH.sub.2 Q-1.1 I.2-202 Ph H CH.sub.2 CH.sub.2 Q-1.2 I.2-203 Ph H CH.sub.2 CH.sub.2 Q-1.3 I.2-204 Ph H CH.sub.2 CH.sub.2 Q-1.16 I.2-205 Ph H CH.sub.2 CH.sub.2 Q-1.17 I.2-206 Ph H CH.sub.2 CH.sub.2 Q-1.18 I.2-207 Ph H CH.sub.2 CH.sub.2 Q-1.31 I.2-208 Ph H CH.sub.2 CH.sub.2 Q-1.32 I.2-209 Ph H CH.sub.2 CH.sub.2 Q-1.33 I.2-210 Ph H CH.sub.2 CH.sub.2 Q-1.91 I.2-211 Ph H CH.sub.2 CH.sub.2 Q-1.92 I.2-212 Ph H CH.sub.2 CH.sub.2 Q-1.93 I.2-213 Ph H CH.sub.2 CH.sub.2 Q-1.106 I.2-214 Ph H CH.sub.2 CH.sub.2 Q-1.107 I.2-215 Ph H CH.sub.2 CH.sub.2 Q-1.108 I.2-216 Ph H CH.sub.2 CH.sub.2 Q-1.121 I.2-217 Ph H CH.sub.2 CH.sub.2 Q-1.122 I.2-218 Ph H CH.sub.2 CH.sub.2 Q-1.123 I.2-219 Ph H CH.sub.2 CH.sub.2 Q-1.136 I.2-220 Ph H CH.sub.2 CH.sub.2 Q-1.137 I.2-221 Ph H CH.sub.2 CH.sub.2 Q-1.138 I.2-222 Ph H CH.sub.2 CH.sub.2 Q-1.166 I.2-223 Ph H CH.sub.2 CH.sub.2 Q-1.167 I.2-224 Ph H CH.sub.2 CH.sub.2 Q-1.168 I.2-225 Ph H CH.sub.2 CH.sub.2 Q-1.171 I.2-226 Ph H CH.sub.2 CH.sub.2 Q-1.172 I.2-227 Ph H CH.sub.2 CH.sub.2 Q-1.173 I.2-228 Ph H CH.sub.2 CH.sub.2 Q-1.176 I.2-229 Ph H CH.sub.2 CH.sub.2 Q-1.177 I.2-230 Ph H CH.sub.2 CH.sub.2 Q-1.178 I.2-231 Ph H CH.sub.2 CH.sub.2 Q-1.181 I.2-232 Ph H CH.sub.2 CH.sub.2 Q-1.182 I.2-233 Ph H CH.sub.2 CH.sub.2 Q-1.183 I.2-234 Ph H CH.sub.2 CH.sub.2 Q-1.201 I.2-235 Ph H CH.sub.2 CH.sub.2 Q-1.202 I.2-236 Ph H CH.sub.2 CH.sub.2 Q-1.203 I.2-237 Ph H CH.sub.2 CH.sub.2 Q-1.204 I.2-238 Ph H CH.sub.2 CH.sub.2 Q-1.205 I.2-239 Ph H CH.sub.2 CH.sub.2 Q-1.206 I.2-241 Ph H CH.sub.2 CH.sub.2 Q-1.207 I.2-242 Ph H CH.sub.2 CH.sub.2 Q-1.208 I.2-243 Ph H CH.sub.2 CH.sub.2 Q-1.209 I.2-244 Ph H CH.sub.2 CH.sub.2 Q-1.210 I.2-245 Ph H CH.sub.2 CH.sub.2 Q-1.211 I.2-246 Ph H CH.sub.2 CH.sub.2 Q-1.212 I.2-247 Ph H CH.sub.2 CH.sub.2 Q-1.213 I.2-248 Ph H CH.sub.2 CH.sub.2 Q-1.216 I.2-249 Ph H CH.sub.2 CH.sub.2 Q-1.217 I.2-250 Ph H CH.sub.2 CH.sub.2 Q-1.218 I.2-251 Ph H CH.sub.2 CH.sub.2 Q-1.246 I.2-252 Ph H CH.sub.2 CH.sub.2 Q-1.247 I.2-253 Ph H CH.sub.2 CH.sub.2 Q-1.248 I.2-254 Ph H CH.sub.2 CH.sub.2 Q-2.1 I.2-255 Ph H CH.sub.2 CH.sub.2 Q-2.2 I.2-256 Ph H CH.sub.2 CH.sub.2 Q-2.3 I.2-257 Ph H CH.sub.2 CH.sub.2 Q-2.5 I.2-258 Ph H CH.sub.2 CH.sub.2 Q-2.4 I.2-259 Ph H CH.sub.2 CH.sub.2 Q-2.7 I.2-260 Ph H CH.sub.2 CH.sub.2 Q-2.9 I.2-261 Ph H CH.sub.2 CH.sub.2 Q-2.12 I.2-262 Ph H CH.sub.2 CH.sub.2 Q-2.13 I.2-263 Ph H CH.sub.2 CH.sub.2 Q-2.14 I.2-264 Ph H CH.sub.2 CH.sub.2 Q-2.61 I.2-265 Ph H CH.sub.2 CH.sub.2 Q-2.62 I.2-266 Ph H CH.sub.2 CH.sub.2 Q-2.63 I.2-267 Ph H CH.sub.2 CH.sub.2 Q-2.64 I.2-268 Ph H CH.sub.2 CH.sub.2 Q-2.65 I.2-269 Ph H CH.sub.2 CH.sub.2 Q-2.67 I.2-270 Ph H CH.sub.2 CH.sub.2 Q-2.69 I.2-271 Ph H CH.sub.2 CH.sub.2 Q-2.72 I.2-272 Ph H CH.sub.2 CH.sub.2 Q-2.73 I.2-273 Ph H CH.sub.2 CH.sub.2 Q-2.74 I.2-274 Ph H CH.sub.2 CH.sub.2 Q-2.80 I.2-275 Ph H CH.sub.2 CH.sub.2 Q-2.105 I.2-276 Ph H CH.sub.2 CH.sub.2 Q-2.106 I.2-277 Ph H CH.sub.2 CH.sub.2 Q-2.108 I.2-278 Ph H CH.sub.2 CH.sub.2 Q-2.145 I.2-279 Ph H CH.sub.2 CH.sub.2 Q-2.146 I.2-280 Ph H CH.sub.2 CH.sub.2 Q-2.147 I.2-281 Ph H CH.sub.2 CH.sub.2 Q-2.161 I.2-282 Ph H CH.sub.2 CH.sub.2 Q-2.162 I.2-283 Ph H CH.sub.2 CH.sub.2 Q-2.163 I.2-284 Ph H CH.sub.2 CH.sub.2 Q-2.164 I.2-285 Ph H CH.sub.2 CH.sub.2 Q-2.165 I.2-286 Ph H CH.sub.2 CH.sub.2 Q-2.167 I.2-287 Ph H CH.sub.2 CH.sub.2 Q-2.168 I.2-288 Ph H CH.sub.2 CH.sub.2 Q-2.169 I.2-289 Ph H CH.sub.2 CH.sub.2 Q-2.172 I.2-290 Ph H CH.sub.2 CH.sub.2 Q-2.173 I.2-291 Ph H CH.sub.2 CH.sub.2 Q-2.174 I.2-292 Ph H CH.sub.2 CH.sub.2 Q-2.180 I.2-293 Ph H CH.sub.2 CH.sub.2 Q-2.185 I.2-294 Ph H CH.sub.2 CH.sub.2 Q-2.189 I.2-295 Ph H CH.sub.2 CH.sub.2 Q-2.190 I.2-296 Ph H CH.sub.2 CH.sub.2 Q-2.201 I.2-297 Ph H CH.sub.2 CH.sub.2 Q-2.202 I.2-298 Ph H CH.sub.2 CH.sub.2 Q-2.203 I.2-299 Ph H CH.sub.2 CH.sub.2 Q-2.204 I.2-300 Ph H CH.sub.2 CH.sub.2 Q-2.205 I.2-301 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-302 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-303 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-304 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-305 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-306 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-307 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-308 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-309 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-310 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-311 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-312 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-313 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-314 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-315 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-316 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-317 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-318 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-319 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-320 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-321 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-322 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-323 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-324 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-325 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-326 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-327 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-328 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-329 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-330 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-331 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-332 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-333 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-334 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-335 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-336 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-337 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-338 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-339 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-340 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-341 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-342 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-343 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-344 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-345 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-346 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-347 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-348 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-349 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-350 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-351 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-352 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-353 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-354 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-355 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-356 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-357 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-358 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-359 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-360 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-361 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-362 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-363 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-364 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-365 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-366 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-367 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-368 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-369 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-370 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-371 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-372 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-373 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-374 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-375 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-376 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-377 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-378 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-379 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-380 Ph CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-381 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-382 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-383 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-384 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-385 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-386 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-387 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-388 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-389 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-390 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-391 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-392 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-393 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-394 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-395 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-396 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-397 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-398 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-399 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-400 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-401 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-402 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-403 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-404 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-405 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-406 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-407 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-408 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-409 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-410 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-411 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-412 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-413 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-414 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-415 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-416 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-417 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-418 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-419 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-420 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-421 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-422 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-423 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-424 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-425 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-426 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-427 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-428 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-429 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-430 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-431 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-432 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-433 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-434 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-435 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-436 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-437 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-438 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-439 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-440 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-441 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-442 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-443 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-444 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-445 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-446 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-447 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-448 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-449 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-450 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-451 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-452 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-453 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-454 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-455 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-456 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-457 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-458 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-459 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-460 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-461 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.1 I.2-462 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.2 I.2-463 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.3 I.2-464 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.16 I.2-465 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.17 I.2-466 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.18 I.2-467 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.136 I.2-468 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.137 I.2-469 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.138 I.2-470 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.166 I.2-471 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.167 I.2-472 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.168 I.2-473 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.201 I.2-474 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.202 I.2-475 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.203 I.2-476 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.206 I.2-477 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.207 I.2-478 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.210 I.2-479 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.211 I.2-480 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Q-1.213 I.2-481 i-Pr CH.sub.3 CHF CH.sub.2 Q-1.3 I.2-482 i-Pr CH.sub.3 CHF CH.sub.2 Q-1.168 I.2-483 i-Pr CH.sub.3 CHF CH.sub.2 Q-1.203 I.2-484 Ph CH.sub.3 CHF CH.sub.2 Q-1.3 I.2-485 Ph CH.sub.3 CHF CH.sub.2 Q-1.168 I.2-486 Ph CH.sub.3 CHF CH.sub.2 Q-1.203 I.2-487 CH.sub.3 CH.sub.3 CHF CH.sub.2 Q-1.3 I.2-488 CH.sub.3 CH.sub.3 CHF CH.sub.2 Q-1.168 I.2-489 CH.sub.3 CH.sub.3 CHF CH.sub.2 Q-1.203 I.2-490 i-Pr CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.3 I.2-491 i-Pr CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.168 I.2-492 i-Pr CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.203 I.2-493 Ph CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.3 I.2-494 Ph CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.168 I.2-495 Ph CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.203 I.2-496 CH.sub.3 CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.3 I.2-497 CH.sub.3 CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.168 I.2-498 CH.sub.3 CH.sub.3 CH(CH.sub.3) CH.sub.2 Q-1.203 I.2-499 i-Pr CH.sub.3 CH(i-Pr) CH.sub.2 Q-1.168 I.2-500 i-Pr CH.sub.3 CH(i-Pr) CH.sub.2 Q-1.203 I.2-501 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.6 I.2-502 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.10 I.2-503 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.11 I.2-504 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.21 I.2-505 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.96 I.2-506 CH.sub.3 H CH.sub.2 CH.sub.2 Q-1.141 I.2-507 i-Pr H CH.sub.2 CH.sub.2 Q-1.6 I.2-508 i-Pr H CH.sub.2 CH.sub.2 Q-1.10 I.2-509 i-Pr H CH.sub.2 CH.sub.2 Q-1.11 I.2-510 i-Pr H CH.sub.2 CH.sub.2 Q-1.21 I.2-511 i-Pr H CH.sub.2 CH.sub.2 Q-1.96 I.2-512 i-Pr H CH.sub.2 CH.sub.2 Q-1.141 I.2-513 Ph H CH.sub.2 CH.sub.2 Q-1.6 I.2-514 Ph H CH.sub.2 CH.sub.2 Q-1.10 I.2-515 Ph H CH.sub.2 CH.sub.2 Q-1.11 I.2-516 Ph H CH.sub.2 CH.sub.2 Q-1.21 I.2-517 Ph H CH.sub.2 CH.sub.2 Q-1.96 I.2-518 Ph H CH.sub.2 CH.sub.2 Q-1.141 I.2-519 c-Pr H CH.sub.2 CH.sub.2 Q-1.6 I.2-520 c-Pr H CH.sub.2 CH.sub.2 Q-1.10 I.2-521 c-Pr H CH.sub.2 CH.sub.2 Q-1.11 I.2-522 c-Pr H CH.sub.2 CH.sub.2 Q-1.21 I.2-523 c-Pr H CH.sub.2 CH.sub.2 Q-1.96 I.2-524 c-Pr H CH.sub.2 CH.sub.2 Q-1.141 I.2-525 c-Pr H CH.sub.2 CH.sub.2 Q-1.1 I.2-526 c-Pr H CH.sub.2 CH.sub.2 Q-1.2 I.2-527 c-Pr H CH.sub.2 CH.sub.2 Q-1.3 I.2-528 c-Pr H CH.sub.2 CH.sub.2 Q-1.16 I.2-529 c-Pr H CH.sub.2 CH.sub.2 Q-1.17 I.2-530 c-Pr H CH.sub.2 CH.sub.2 Q-1.18 I.2-531 c-Pr H CH.sub.2 CH.sub.2 Q-1.91 I.2-532 c-Pr H CH.sub.2 CH.sub.2 Q-1.92 I.2-533 c-Pr H CH.sub.2 CH.sub.2 Q-1.136 I.2-534 c-Pr H CH.sub.2 CH.sub.2 Q-1.137 I.2-535 c-Pr H CH.sub.2 CH.sub.2 Q-1.138 I.2-536 c-Pr H CH.sub.2 CH.sub.2 Q-1.166 I.2-537 c-Pr H CH.sub.2 CH.sub.2 Q-1.167 I.2-538 c-Pr H CH.sub.2 CH.sub.2 Q-1.168 I.2-539 c-Pr H CH.sub.2 CH.sub.2 Q-1.171 I.2-540 c-Pr H CH.sub.2 CH.sub.2 Q-1.172 I.2-541 c-Pr H CH.sub.2 CH.sub.2 Q-1.173 I.2-542 c-Pr H CH.sub.2 CH.sub.2 Q-1.201 I.2-543 c-Pr H CH.sub.2 CH.sub.2 Q-1.202 I.2-544 c-Pr H CH.sub.2 CH.sub.2 Q-1.203 I.2-545 c-Pr H CH.sub.2 CH.sub.2 Q-1.206 I.2-546 c-Pr H CH.sub.2 CH.sub.2 Q-1.210 I.2-547 c-Pr H CH.sub.2 CH.sub.2 Q-2.1 I.2-548 c-Pr H CH.sub.2 CH.sub.2 Q-2.5 I.2-559 c-Bu H CH.sub.2 CH.sub.2 Q-1.6 I.2-550 c-Bu H CH.sub.2 CH.sub.2 Q-1.10 I.2-551 c-Bu H CH.sub.2 CH.sub.2 Q-1.11 I.2-552 c-Bu H CH.sub.2 CH.sub.2 Q-1.21 I.2-553 c-Bu H CH.sub.2 CH.sub.2 Q-1.96 I.2-554 c-Bu H CH.sub.2 CH.sub.2 Q-1.141 I.2-555 c-Bu H CH.sub.2 CH.sub.2 Q-1.1 I.2-556 c-Bu H CH.sub.2 CH.sub.2 Q-1.2 I.2-557 c-Bu H CH.sub.2 CH.sub.2 Q-1.3 I.2-558 c-Bu H CH.sub.2 CH.sub.2 Q-1.16 I.2-559 c-Bu H CH.sub.2 CH.sub.2 Q-1.17 I.2-560 c-Bu H CH.sub.2 CH.sub.2 Q-1.18 I.2-561 c-Bu H CH.sub.2 CH.sub.2 Q-1.91 I.2-562 c-Bu H CH.sub.2 CH.sub.2 Q-1.92 I.2-563 c-Bu H CH.sub.2 CH.sub.2 Q-1.136 I.2-564 c-Bu H CH.sub.2 CH.sub.2 Q-1.137 I.2-565 c-Bu H CH.sub.2 CH.sub.2 Q-1.138 I.2-566 c-Bu H CH.sub.2 CH.sub.2 Q-1.166 I.2-567 c-Bu H CH.sub.2 CH.sub.2 Q-1.167 I.2-568 c-Bu H CH.sub.2 CH.sub.2 Q-1.168 I.2-569 c-Bu H CH.sub.2 CH.sub.2 Q-1.171 I.2-570 c-Bu H CH.sub.2 CH.sub.2 Q-1.172 I.2-571 c-Bu H CH.sub.2 CH.sub.2 Q-1.173 I.2-572 c-Bu H CH.sub.2 CH.sub.2 Q-1.201 I.2-573 c-Bu H CH.sub.2 CH.sub.2 Q-1.202 I.2-574 c-Bu H CH.sub.2 CH.sub.2 Q-1.203 I.2-575 c-Bu H CH.sub.2 CH.sub.2 Q-1.206 I.2-576 c-Bu H CH.sub.2 CH.sub.2 Q-1.210 I.2-577 c-Bu H CH.sub.2 CH.sub.2 Q-2.1 I.2-578 c-Bu H CH.sub.2 CH.sub.2 Q-2.5 I.2-579 c-Hex H CH.sub.2 CH.sub.2 Q-1.2 I.2-580 c-Hex H CH.sub.2 CH.sub.2 Q-1.10 I.2-581 c-Hex H CH.sub.2 CH.sub.2 Q-1.137 I.2-582 c-Hex H CH.sub.2 CH.sub.2 Q-1.141 I.2-583 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.2 I.2-584 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.10 I.2-585 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.137 I.2-586 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.141 I.2-587 Adamantyl H CH.sub.2 CH.sub.2 Q-1.2 I.2-588 Adamantyl H CH.sub.2 CH.sub.2 Q-1.10 I.2-589 Adamantyl H CH.sub.2 CH.sub.2 Q-1.137 I.2-590 Adamantyl H CH.sub.2 CH.sub.2 Q-1.141 I.2-591 4-CH.sub.3Ph H CH.sub.2 CH.sub.2 Q-1.2 I.2-592 4-CH.sub.3Ph H CH.sub.2 CH.sub.2 Q-1.10 I.2-593 4-CH.sub.3Ph H CH.sub.2 CH.sub.2 Q-1.137 I.2-594 4-CH.sub.3Ph H CH.sub.2 CH.sub.2 Q-1.141 I.2-595 3-FPh H CH.sub.2 CH.sub.2 Q-1.2 I.2-596 3-FPh H CH.sub.2 CH.sub.2 Q-1.10 I.2-597 3-FPh H CH.sub.2 CH.sub.2 Q-1.137 I.2-598 3-FPh H CH.sub.2 CH.sub.2 Q-1.141 I.2-599 c-Pent H CH.sub.2 CH.sub.2 Q-1.2 I.2-600 c-Pent H CH.sub.2 CH.sub.2 Q-1.10 I.2-601 c-Pent H CH.sub.2 CH.sub.2 Q-1.137 I.2-602 c-Pent H CH.sub.2 CH.sub.2 Q-1.141 I.2-603 t-Bu H CH.sub.2 CH.sub.2 Q-1.2 I.2-604 t-Bu H CH.sub.2 CH.sub.2 Q-1.10 I.2-605 t-Bu H CH.sub.2 CH.sub.2 Q-1.137 I.2-606 t-Bu H CH.sub.2 CH.sub.2 Q-1.141 I.2-607 2-FPh H CH.sub.2 CH.sub.2 Q-1.2 I.2-608 2-FPh H CH.sub.2 CH.sub.2 Q-1.10 I.2-609 2-FPh H CH.sub.2 CH.sub.2 Q-1.137 I.2-610 2-FPh H CH.sub.2 CH.sub.2 Q-1.141 I.2-611 4-ClPh H CH.sub.2 CH.sub.2 Q-1.2 I.2-612 4-ClPh H CH.sub.2 CH.sub.2 Q-1.10 I.2-613 4-ClPh H CH.sub.2 CH.sub.2 Q-1.137 I.2-614 4-ClPh H CH.sub.2 CH.sub.2 Q-1.141 I.2-615 1-Ethylpropyl H CH.sub.2 CH.sub.2 Q-1.203 I.2-616 c-Hex H CH.sub.2 CH.sub.2 Q-1.203 I.2-617 4-CH.sub.3Ph H CH.sub.2 CH.sub.2 Q-1.203 I.2-618 c-Pent H CH.sub.2 CH.sub.2 Q-1.138 I.2-619 t-Bu H CH.sub.2 CH.sub.2 Q-1.203 I.2-620 t-Bu H CH.sub.2 CH.sub.2 Q-1.138

TABLE-US-00004 TABLE 3 (I) [00570] No. R.sup.1 R.sup.2 A.sup.1 A.sup.2 W Q I.3-1 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.1 I.3-2 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.2 I.3-3 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.3 I.3-4 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.16 I.3-5 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.17 I.3-6 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.18 I.3-7 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.91 I.3-8 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.92 I.3-9 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.93 I.3-10 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.136 I.3-11 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.137 I.3-12 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.138 I.3-13 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.166 I.3-14 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.167 I.3-15 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.168 I.3-16 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.201 I.3-17 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.202 I.3-18 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.203 I.3-19 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.246 I.3-20 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.247 I.3-21 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.248 I.3-22 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.1 I.3-23 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.2 I.3-24 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.3 I.3-25 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.16 I.3-26 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.17 I.3-27 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.18 I.3-28 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.91 I.3-29 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.92 I.3-30 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.93 I.3-31 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.136 I.3-32 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.137 I.3-33 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.138 I.3-34 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.166 I.3-35 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.167 I.3-36 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.168 I.3-37 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.201 I.3-38 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.202 I.3-39 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.203 I.3-40 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.246 I.3-41 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.247 I.3-42 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.248 I.3-43 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.1 I.3-44 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.2 I.3-45 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.3 I.3-46 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.16 I.3-47 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.17 I.3-48 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.18 I.3-49 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.91 I.3-50 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.92 I.3-51 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.93 I.3-52 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.136 I.3-53 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.137 I.3-54 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.138 I.3-55 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.166 I.3-56 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.167 I.3-57 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.168 I.3-58 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.201 I.3-59 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.202 I.3-60 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.203 I.3-61 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.246 I.3-62 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.247 I.3-63 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.248 I.3-64 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.1 I.3-65 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.2 I.3-66 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.3 I.3-67 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.16 I.3-68 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.17 I.3-69 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.18 I.3-70 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.91 I.3-71 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.92 I.3-72 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.93 I.3-73 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.136 I.3-74 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.137 I.3-75 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.138 I.3-76 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.166 I.3-77 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.167 I.3-78 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.168 I.3-79 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.201 I.3-80 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.202 I.3-81 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.203 I.3-82 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.246 I.3-83 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.247 I.3-84 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.248 I.3-85 i-Pr H CH.sub.2 O CH.sub.2 Q-1.1 I.3-86 i-Pr H CH.sub.2 O CH.sub.2 Q-1.2 I.3-87 i-Pr H CH.sub.2 O CH.sub.2 Q-1.3 I.3-88 i-Pr H CH.sub.2 O CH.sub.2 Q-1.16 I.3-89 i-Pr H CH.sub.2 O CH.sub.2 Q-1.17 I.3-90 i-Pr H CH.sub.2 O CH.sub.2 Q-1.18 I.3-91 i-Pr H CH.sub.2 O CH.sub.2 Q-1.91 I.3-92 i-Pr H CH.sub.2 O CH.sub.2 Q-1.92 I.3-93 i-Pr H CH.sub.2 O CH.sub.2 Q-1.93 I.3-94 i-Pr H CH.sub.2 O CH.sub.2 Q-1.136 I.3-95 i-Pr H CH.sub.2 O CH.sub.2 Q-1.137 I.3-96 i-Pr H CH.sub.2 O CH.sub.2 Q-1.138 I.3-97 i-Pr H CH.sub.2 O CH.sub.2 Q-1.166 I.3-98 i-Pr H CH.sub.2 O CH.sub.2 Q-1.167 I.3-99 i-Pr H CH.sub.2 O CH.sub.2 Q-1.168 I.3-100 i-Pr H CH.sub.2 O CH.sub.2 Q-1.201 I.3-101 i-Pr H CH.sub.2 O CH.sub.2 Q-1.202 I.3-102 i-Pr H CH.sub.2 O CH.sub.2 Q-1.203 I.3-103 i-Pr H CH.sub.2 O CH.sub.2 Q-1.246 I.3-104 i-Pr H CH.sub.2 O CH.sub.2 Q-1.247 I.3-105 i-Pr H CH.sub.2 O CH.sub.2 Q-1.248 I.3-106 Ph H CH.sub.2 O CH.sub.2 Q-1.1 I.3-107 Ph H CH.sub.2 O CH.sub.2 Q-1.2 I.3-108 Ph H CH.sub.2 O CH.sub.2 Q-1.3 I.3-109 Ph H CH.sub.2 O CH.sub.2 Q-1.16 I.3-110 Ph H CH.sub.2 O CH.sub.2 Q-1.17 I.3-111 Ph H CH.sub.2 O CH.sub.2 Q-1.18 I.3-112 Ph H CH.sub.2 O CH.sub.2 Q-1.91 I.3-113 Ph H CH.sub.2 O CH.sub.2 Q-1.92 I.3-114 Ph H CH.sub.2 O CH.sub.2 Q-1.93 I.3-115 Ph H CH.sub.2 O CH.sub.2 Q-1.136 I.3-116 Ph H CH.sub.2 O CH.sub.2 Q-1.137 I.3-117 Ph H CH.sub.2 O CH.sub.2 Q-1.138 I.3-118 Ph H CH.sub.2 O CH.sub.2 Q-1.166 I.3-119 Ph H CH.sub.2 O CH.sub.2 Q-1.167 I.3-120 Ph H CH.sub.2 O CH.sub.2 Q-1.168 I.3-121 Ph H CH.sub.2 O CH.sub.2 Q-1.201 I.3-122 Ph H CH.sub.2 O CH.sub.2 Q-1.202 I.3-123 Ph H CH.sub.2 O CH.sub.2 Q-1.203 I.3-124 Ph H CH.sub.2 O CH.sub.2 Q-1.246 I.3-125 Ph H CH.sub.2 O CH.sub.2 Q-1.247 I.3-126 Ph H CH.sub.2 O CH.sub.2 Q-1.248 I.3-127 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.6 I.3-128 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.10 I.3-129 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.11 I.3-130 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.21 I.3-131 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.96 I.3-132 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.141 I.3-133 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.6 I.3-134 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.10 I.3-135 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.11 I.3-136 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.21 I.3-137 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.96 I.3-138 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.141

TABLE-US-00005 TABLE 4 (I) [00571] No. R.sub.1 R.sub.2 A.sub.1 A.sub.2 W Q I.4-1 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.1 I.4-2 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.2 I.4-3 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.3 I.4-4 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.16 I.4-5 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.17 I.4-6 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.18 I.4-7 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.91 I.4-8 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.92 I.4-9 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.93 I.4-10 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.136 I.4-11 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.137 I.4-12 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.138 I.4-13 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.166 I.4-14 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.167 I.4-15 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.168 I.4-16 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.201 I.4-17 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.202 I.4-18 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.203 I.4-19 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.246 I.4-20 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.247 I.4-21 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.248 I.4-22 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.1 I.4-23 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.2 I.4-24 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.3 I.4-25 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.16 I.4-26 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.17 I.4-27 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.18 I.4-28 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.91 I.4-29 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.92 I.4-30 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.93 I.4-31 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.136 I.4-32 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.137 I.4-33 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.138 I.4-34 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.166 I.4-35 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.167 I.4-36 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.168 I.4-37 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.201 I.4-38 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.202 I.4-39 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.203 I.4-40 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.246 I.4-41 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.247 I.4-42 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.248 I.4-43 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.1 I.4-44 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.2 I.4-45 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.3 I.4-46 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.16 I.4-47 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.17 I.4-48 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.18 I.4-49 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.91 I.4-50 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.92 I.4-51 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.93 I.4-52 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.136 I.4-53 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.137 I.4-54 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.138 I.4-55 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.166 I.4-56 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.167 I.4-57 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.168 I.4-58 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.201 I.4-59 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.202 I.4-60 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.203 I.4-61 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.246 I.4-62 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.247 I.4-63 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.248 I.4-64 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.1 I.4-65 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.2 I.4-66 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.3 I.4-67 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.16 I.4-68 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.17 I.4-69 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.18 I.4-70 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.91 I.4-71 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.92 I.4-72 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.93 I.4-73 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.136 I.4-74 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.137 I.4-75 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.138 I.4-76 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.166 I.4-77 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.167 I.4-78 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.168 I.4-79 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.201 I.4-80 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.202 I.4-81 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.203 I.4-82 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.246 I.4-83 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.247 I.4-84 CH.sub.3 H CH.sub.2 O CH.sub.2 Q-1.248 I.4-85 i-Pr H CH.sub.2 O CH.sub.2 Q-1.1 I.4-86 i-Pr H CH.sub.2 O CH.sub.2 Q-1.2 I.4-87 i-Pr H CH.sub.2 O CH.sub.2 Q-1.3 I.4-88 i-Pr H CH.sub.2 O CH.sub.2 Q-1.16 I.4-89 i-Pr H CH.sub.2 O CH.sub.2 Q-1.17 I.4-90 i-Pr H CH.sub.2 O CH.sub.2 Q-1.18 I.4-91 i-Pr H CH.sub.2 O CH.sub.2 Q-1.91 I.4-92 i-Pr H CH.sub.2 O CH.sub.2 Q-1.92 I.4-93 i-Pr H CH.sub.2 O CH.sub.2 Q-1.93 I.4-94 i-Pr H CH.sub.2 O CH.sub.2 Q-1.136 I.4-95 i-Pr H CH.sub.2 O CH.sub.2 Q-1.137 I.4-96 i-Pr H CH.sub.2 O CH.sub.2 Q-1.138 I.4-97 i-Pr H CH.sub.2 O CH.sub.2 Q-1.166 I.4-98 i-Pr H CH.sub.2 O CH.sub.2 Q-1.167 I.4-99 i-Pr H CH.sub.2 O CH.sub.2 Q-1.168 I.4-100 i-Pr H CH.sub.2 O CH.sub.2 Q-1.201 I.4-101 i-Pr H CH.sub.2 O CH.sub.2 Q-1.202 I.4-102 i-Pr H CH.sub.2 O CH.sub.2 Q-1.203 I.4-103 i-Pr H CH.sub.2 O CH.sub.2 Q-1.246 I.4-104 i-Pr H CH.sub.2 O CH.sub.2 Q-1.247 I.4-105 i-Pr H CH.sub.2 O CH.sub.2 Q-1.248 I.4-106 Ph H CH.sub.2 O CH.sub.2 Q-1.1 I.4-107 Ph H CH.sub.2 O CH.sub.2 Q-1.2 I.4-108 Ph H CH.sub.2 O CH.sub.2 Q-1.3 I.4-109 Ph H CH.sub.2 O CH.sub.2 Q-1.16 I.4-110 Ph H CH.sub.2 O CH.sub.2 Q-1.17 I.4-111 Ph H CH.sub.2 O CH.sub.2 Q-1.18 I.4-112 Ph H CH.sub.2 O CH.sub.2 Q-1.91 I.4-113 Ph H CH.sub.2 O CH.sub.2 Q-1.92 I.4-114 Ph H CH.sub.2 O CH.sub.2 Q-1.93 I.4-115 Ph H CH.sub.2 O CH.sub.2 Q-1.136 I.4-116 Ph H CH.sub.2 O CH.sub.2 Q-1.137 I.4-117 Ph H CH.sub.2 O CH.sub.2 Q-1.138 I.4-118 Ph H CH.sub.2 O CH.sub.2 Q-1.166 I.4-119 Ph H CH.sub.2 O CH.sub.2 Q-1.167 I.4-120 Ph H CH.sub.2 O CH.sub.2 Q-1.168 I.4-121 Ph H CH.sub.2 O CH.sub.2 Q-1.201 I.4-122 Ph H CH.sub.2 O CH.sub.2 Q-1.202 I.4-123 Ph H CH.sub.2 O CH.sub.2 Q-1.203 I.4-124 Ph H CH.sub.2 O CH.sub.2 Q-1.246 I.4-125 Ph H CH.sub.2 O CH.sub.2 Q-1.247 I.4-126 Ph H CH.sub.2 O CH.sub.2 Q-1.248 I.4-127 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.6 I.4-128 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.10 I.4-129 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.11 I.4-130 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.21 I.4-131 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.96 I.4-132 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.141 I.4-133 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.6 I.4-134 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.10 I.4-135 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.11 I.4-136 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.21 I.4-137 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.96 I.4-138 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Q-1.141 The Q radicals here correspond to the structures defined as particularly preferred earlier in the document

TABLE-US-00006 TABLE 5 (II) [00572] No. R.sup.1 R.sup.2 A.sup.1 A.sup.2 II.1-1 CH.sub.3 H CH.sub.2 CH.sub.2 II.1-2 i-Pr H CH.sub.2 CH.sub.2 II.1-3 Ph H CH.sub.2 CH.sub.2 II.1-4 Et H CH.sub.2 CH.sub.2 II.1-5 c-Pr H CH.sub.2 CH.sub.2 II.1-6 n-Pr H CH.sub.2 CH.sub.2 II.1-7 pFPh H CH.sub.2 CH.sub.2 II.1-8 mFPh H CH.sub.2 CH.sub.2 II.1-9 pClPh H CH.sub.2 CH.sub.2 II.1-10 mClPh H CH.sub.2 CH.sub.2 II.1-11 pCH.sub.3Ph H CH.sub.2 CH.sub.2 II.1-12 mCH.sub.3Ph H CH.sub.2 CH.sub.2 II.1-13 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 II.1-14 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 II.1-15 Ph CH.sub.3 CH.sub.2 CH.sub.2 II.1-16 Et CH.sub.3 CH.sub.2 CH.sub.2 II.1-17 c-Pr CH.sub.3 CH.sub.2 CH.sub.2 II.1-18 n-Pr CH.sub.3 CH.sub.2 CH.sub.2 II.1-19 pFPh CH.sub.3 CH.sub.2 CH.sub.2 II.1-20 mFPh CH.sub.3 CH.sub.2 CH.sub.2 II.1-21 pClPh CH.sub.3 CH.sub.2 CH.sub.2 II.1-22 mClPh CH.sub.3 CH.sub.2 CH.sub.2 II.1-23 pCH.sub.3Ph CH.sub.3 CH.sub.2 CH.sub.2 II.1-24 mCH.sub.3Ph CH.sub.3 CH.sub.2 CH.sub.2 II.1-25 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-26 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-27 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-28 Et C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-29 c-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-30 n-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-31 pFPh C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-32 mFPh C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-33 pClPh C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-34 mClPh C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-35 pCH.sub.3Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-36 mCH.sub.3Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 II.1-37 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-38 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-39 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-40 Et SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-41 c-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-42 n-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-43 pFPh SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-44 mFPh SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-45 pClPh SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-46 mClPh SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-47 pCH.sub.3Ph SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-48 mCH.sub.3Ph SiEt.sub.3 CH.sub.2 CH.sub.2 II.1-49 CH.sub.3 H CHF CH.sub.2 II.1-50 i-Pr H CHF CH.sub.2 II.1-51 Ph H CHF CH.sub.2 II.1-52 CH.sub.3 H CH(CH.sub.3) CH.sub.2 II.1-53 i-Pr H CH(CH.sub.3) CH.sub.2 II.1-54 Ph H CH(CH.sub.3) CH.sub.2 II.1-55 CH.sub.3 H CH(i-Pr) CH.sub.2 II.1-56 i-Pr H CH(i-Pr) CH.sub.2 II.1-57 Ph H CH(i-Pr) CH.sub.2 II.1-58 CH.sub.3 H CH(c-Pr) CH.sub.2 II.1-59 i-Pr H CH(c-Pr) CH.sub.2 II.1-60 Ph H CH(c-Pr) CH.sub.2 II.1-61 CH.sub.3 H CF.sub.2 CH.sub.2 II.1-62 i-Pr H CF.sub.2 CH.sub.2 II.1-63 Ph H CF.sub.2 CH.sub.2 II.1-64 CH.sub.3 H CH.sub.2 CHF II.1-65 i-Pr H CH.sub.2 CHF II.1-66 Ph H CH.sub.2 CHF II.1-67 CH.sub.3 H CH.sub.2 CH(CH.sub.3) II.1-68 i-Pr H CH.sub.2 CH(CH.sub.3) II.1-69 Ph H CH.sub.2 CH(CH.sub.3) II.1-70 CH.sub.3 H CH.sub.2 CH(i-Pr) II.1-71 i-Pr H CH.sub.2 CH(i-Pr) II.1-72 Ph H CH.sub.2 CH(i-Pr) II.1-73 CH.sub.3 H CH.sub.2 CH(c-Pr) II.1-74 i-Pr H CH.sub.2 CH(c-Pr) II.1-75 Ph H CH.sub.2 CH(c-Pr) II.1-76 CH.sub.3 H CH.sub.2 CF.sub.2 II.1-77 i-Pr H CH.sub.2 CF.sub.2 II.1-78 Ph H CH.sub.2 CF.sub.2 II.1-79 2,4-Cl.sub.2Ph H CH.sub.2 CH.sub.2 II.1-80 c-Bu H CH.sub.2 CH.sub.2 II.1-81 c-Pent H CH.sub.2 CH.sub.2 II.1-82 c-Hex H CH.sub.2 CH.sub.2 II.1-83 Adamantyl H CH.sub.2 CH.sub.2 II.1-84 1-Ethyl-propyl H CH.sub.2 CH.sub.2 II.1-85 t-Bu H CH.sub.2 CH.sub.2 II.1-86 oFPh H CH.sub.2 CH.sub.2

TABLE-US-00007 TABLE 6 (II) [00573] No. R.sup.1 R.sup.2 A.sup.1 A.sup.2 W II.2-1 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 II.2-2 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 II.2-3 Ph H CH.sub.2 CH.sub.2 CH.sub.2 II.2-4 n-Pr H CH.sub.2 CH.sub.2 CH.sub.2 II.2-5 c-Pr H CH.sub.2 CH.sub.2 CH.sub.2 II.2-6 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-7 i-Pr CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-8 Ph CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-9 n-Pr CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-10 c-Pr CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-11 CH.sub.3 C(O)CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-12 i-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-13 Ph C(O)CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-14 n-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-15 c-Pr C(O)CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-16 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-17 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-18 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-19 n-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-20 c-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 II.2-21 CH.sub.3 H CH.sub.2 O CH.sub.2 II.2-22 i-Pr H CH.sub.2 O CH.sub.2 II.2-23 Ph H CH.sub.2 O CH.sub.2 II.2-24 n-Pr H CH.sub.2 O CH.sub.2 II.2-25 c-Pr H CH.sub.2 O CH.sub.2 II.2-26 CH.sub.3 CH.sub.3 CH.sub.2 O CH.sub.2 II.2-27 i-Pr CH.sub.3 CH.sub.2 O CH.sub.2 II.2-28 Ph CH.sub.3 CH.sub.2 O CH.sub.2 II.2-29 n-Pr CH.sub.3 CH.sub.2 O CH.sub.2 II.2-30 c-Pr CH.sub.3 CH.sub.2 O CH.sub.2 II.2-31 CH.sub.3 C(O)CH.sub.3 CH.sub.2 O CH.sub.2 II.2-32 i-Pr C(O)CH.sub.3 CH.sub.2 O CH.sub.2 II.2-33 Ph C(O)CH.sub.3 CH.sub.2 O CH.sub.2 II.2-34 n-Pr C(O)CH.sub.3 CH.sub.2 O CH.sub.2 II.2-35 c-Pr C(O)CH.sub.3 CH.sub.2 O CH.sub.2 II.2-36 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 II.2-37 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 II.2-38 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 II.2-39 n-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 II.2-40 c-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 II.2-41 c-Bu H CH.sub.2 CH.sub.2 CH.sub.2 II.2-42 c-Pentyl H CH.sub.2 CH.sub.2 CH.sub.2 II.2-43 c-Hexyl H CH.sub.2 CH.sub.2 CH.sub.2 II.2-44 pFPh H CH.sub.2 CH.sub.2 CH.sub.2 II.2-45 pMePh H CH.sub.2 CH.sub.2 CH.sub.2 II.2-46 pClPh H CH.sub.2 CH.sub.2 CH.sub.2 II.2-47 mFPh H CH.sub.2 CH.sub.2 CH.sub.2 II.2-48 mMePh H CH.sub.2 CH.sub.2 CH.sub.2 II.2-49 mClPh H CH.sub.2 CH.sub.2 CH.sub.2 II.2-50 Adamantyl H CH.sub.2 CH.sub.2 CH.sub.2 II.2-51 t-Bu H CH.sub.2 CH.sub.2 CH.sub.2 II.2-52 1-Ethyl-propyl H CH.sub.2 CH.sub.2 CH.sub.2

TABLE-US-00008 TABLE 7 (III) [00574] No. R.sup.1 R.sup.2 A.sup.1 A.sup.2 [M] III.1-1 CH.sub.3 H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-2 i-Pr H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-3 Ph H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-4 Et H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-5 c-Pr H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-6 n-Pr H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-7 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-8 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-9 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-10 c-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-11 CH.sub.3 H CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.1-12 i-Pr H CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.1-13 Ph H CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.1-14 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.1-15 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.1-16 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.1-17 CH.sub.3 H CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.1-18 i-Pr H CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.1-19 Ph H CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.1-20 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.1-21 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.1-22 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.1-23 CH.sub.3 H CH.sub.2 CH.sub.2 GeEt.sub.3 III.1-24 i-Pr H CH.sub.2 CH.sub.2 GeEt.sub.3 III.1-25 Ph H CH.sub.2 CH.sub.2 GeEt.sub.3 III.1-26 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 GeEt.sub.3 III.1-27 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 GeEt.sub.3 III.1-28 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 GeEt.sub.3 III.1-29 CH.sub.3 H CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.1-30 i-Pr H CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.1-31 Ph H CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.1-32 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.1-33 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.1-34 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.1-35 CH.sub.3 H CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.1-36 i-Pr H CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.1-37 Ph H CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.1-38 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.1-39 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.1-40 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.1-41 CH.sub.3 H CH.sub.2 CH.sub.2 B(OH).sub.2 III.1-42 i-Pr H CH.sub.2 CH.sub.2 B(OH).sub.2 III.1-43 Ph H CH.sub.2 CH.sub.2 B(OH).sub.2 III.1-44 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 B(OH).sub.2 III.1-45 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 B(OH).sub.2 III.1-46 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 B(OH).sub.2 III.1-47 CH.sub.3 H CH.sub.2 CH.sub.2 B(OMe).sub.2 III.1-48 i-Pr H CH.sub.2 CH.sub.2 B(OMe).sub.2 III.1-49 Ph H CH.sub.2 CH.sub.2 B(OMe).sub.2 III.1-50 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.1-51 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.1-52 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.1-53 CH.sub.3 H CH.sub.2 CH.sub.2 [00575] III.1-54 i-Pr H CH.sub.2 CH.sub.2 [00576] III.1-55 Ph H CH.sub.2 CH.sub.2 [00577] III.1-56 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 [00578] III.1-57 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 [00579] III.1-58 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 [00580] III.1-59 CH.sub.3 H CH.sub.2 CH.sub.2 [00581] III.1-60 i-Pr H CH.sub.2 CH.sub.2 [00582] III.1-61 Ph H CH.sub.2 CH.sub.2 [00583] III.1-62 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 [00584] III.1-63 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 [00585] III.1-64 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 [00586] III.1-65 c-Bu H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-66 c-Hexyl H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-67 1-Ethylpropyl H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-68 Adamantyl H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-69 pFPh H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-70 mFPh H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-71 pClPh H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-72 mClPh H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-73 pCH.sub.3Ph H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-74 mCH.sub.3Ph H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-75 t-Bu H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.1-76 c-Pentyl H CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3

TABLE-US-00009 TABLE 8 (III) [00587] No. R.sup.1 R.sup.2 A.sup.1 A.sup.2 W [M] III.2-1 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-2 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-3 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-4 Et H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-5 c-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-6 n-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-7 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-8 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-9 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-10 c-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Bu).sub.3 III.2-11 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.2-12 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.2-13 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.2-14 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.2-15 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.2-16 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(n-Pr).sub.3 III.2-17 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.2-18 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.2-19 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.2-20 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.2-21 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.2-22 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Sn(c-Hex).sub.3 III.2-23 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 GeEt.sub.3 III.2-24 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 GeEt.sub.3 III.2-25 Ph H CH.sub.2 CH.sub.2 CH.sub.2 GeEt.sub.3 III.2-26 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 GeEt.sub.3 III.2-27 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 GeEt.sub.3 III.2-28 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 GeEt.sub.3 III.2-29 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-30 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-31 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-32 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-33 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-34 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-35 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-36 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-37 Ph H CH.sub.2 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-38 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-39 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-40 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-41 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 B(OH).sub.2 III.2-42 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 B(OH).sub.2 III.2-43 Ph H CH.sub.2 CH.sub.2 CH.sub.2 B(OH).sub.2 III.2-44 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 B(OH).sub.2 III.2-45 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 B(OH).sub.2 III.2-46 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 B(OH).sub.2 III.2-47 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.2-48 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.2-49 Ph H CH.sub.2 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.2-50 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.2-51 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.2-52 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 B(OMe).sub.2 III.2-53 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 [00588] III.2-54 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 [00589] III.2-55 Ph H CH.sub.2 CH.sub.2 CH.sub.2 [00590] III.2-56 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 [00591] III.2-57 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 [00592] III.2-58 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 [00593] III.2-59 CH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2 [00594] III.2-60 i-Pr H CH.sub.2 CH.sub.2 CH.sub.2 [00595] III.2-61 Ph H CH.sub.2 CH.sub.2 CH.sub.2 [00596] III.2-62 CH.sub.3 SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 [00597] III.2-63 i-Pr SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 [00598] III.2-64 Ph SiEt.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 [00599] III.2-65 CH.sub.3 H CH.sub.2 O CH.sub.2 Sn(n-Bu).sub.3 III.2-66 i-Pr H CH.sub.2 O CH.sub.2 Sn(n-Bu).sub.3 III.2-67 Ph H CH.sub.2 O CH.sub.2 Sn(n-Bu).sub.3 III.2-68 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(n-Bu).sub.3 III.2-69 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(n-Bu).sub.3 III.2-70 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(n-Bu).sub.3 III.2-71 c-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(n-Bu).sub.3 III.2-72 CH.sub.3 H CH.sub.2 O CH.sub.2 Sn(n-Pr).sub.3 III.2-73 i-Pr H CH.sub.2 O CH.sub.2 Sn(n-Pr).sub.3 III.2-74 Ph H CH.sub.2 O CH.sub.2 Sn(n-Pr).sub.3 III.2-75 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(n-Pr).sub.3 III.2-76 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(n-Pr).sub.3 III.2-77 CH.sub.3 H CH.sub.2 O CH.sub.2 Sn(c-Hex).sub.3 III.2-78 i-Pr H CH.sub.2 O CH.sub.2 Sn(c-Hex).sub.3 III.2-79 Ph H CH.sub.2 O CH.sub.2 Sn(c-Hex).sub.3 III.2-80 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(c-Hex).sub.3 III.2-81 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(c-Hex).sub.3 III.2-82 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 Sn(c-Hex).sub.3 III.2-83 CH.sub.3 H CH.sub.2 O CH.sub.2 GeEt.sub.3 III.2-84 i-Pr H CH.sub.2 O CH.sub.2 GeEt.sub.3 III.2-85 Ph H CH.sub.2 O CH.sub.2 GeEt.sub.3 III.2-86 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 GeEt.sub.3 III.2-87 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 GeEt.sub.3 III.2-88 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 GeEt.sub.3 III.2-89 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-90 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-91 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 Zr(C.sub.5H.sub.5).sub.2 III.2-92 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-93 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-94 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 Hf(C.sub.5H.sub.5).sub.2 III.2-95 CH.sub.3 H CH.sub.2 O CH.sub.2 B(OH).sub.2 III.2-96 i-Pr H CH.sub.2 O CH.sub.2 B(OH).sub.2 III.2-97 Ph H CH.sub.2 O CH.sub.2 B(OH).sub.2 III.2-98 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 B(OH).sub.2 III.2-99 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 B(OH).sub.2 III.2-100 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 B(OH).sub.2 III.2-101 CH.sub.3 H CH.sub.2 O CH.sub.2 B(OMe).sub.2 III.2-102 i-Pr H CH.sub.2 O CH.sub.2 B(OMe).sub.2 III.2-103 Ph H CH.sub.2 O CH.sub.2 B(OMe).sub.2 III.2-104 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 B(OMe).sub.2 III.2-105 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 B(OMe).sub.2 III.2-106 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 B(OMe).sub.2 III.2-107 CH.sub.3 H CH.sub.2 O CH.sub.2 [00600] III.2-108 i-Pr H CH.sub.2 O CH.sub.2 [00601] III.2-109 Ph H CH.sub.2 O CH.sub.2 [00602] III.2-110 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 [00603] III.2-111 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 [00604] III.2-112 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 [00605] III.2-113 CH.sub.3 H CH.sub.2 O CH.sub.2 [00606] III.2-114 i-Pr H CH.sub.2 O CH.sub.2 [00607] III.2-115 Ph H CH.sub.2 O CH.sub.2 [00608] III.2-116 CH.sub.3 SiEt.sub.3 CH.sub.2 O CH.sub.2 [00609] III.2-117 i-Pr SiEt.sub.3 CH.sub.2 O CH.sub.2 [00610] III.2-118 Ph SiEt.sub.3 CH.sub.2 O CH.sub.2 [00611]

[0296] Spectroscopic Data of Selected Table Examples:

Example No. I.1-36

[0297] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (s, 1H), 4.19 (q, 2H), 2.87 (br. s, 1H, OH), 2.02 (s, 3H), 1.80 (s, 3H), 1.44 (m, 1H), 1.34 (m, 1H), 1.28 (t, 3H), 1.23 (m, 2H).

Example No. I.1-102

[0298] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (s, 1H), 3.72 (s, 3H), 2.72 (br. s, 1H, OH), 2.47 (sept, 1H), 2.30 (q, 2H), 1.44 (m, 1H), 1.42 (m, 1H), 1.30 (m, 1H), 1.22 (m, 1H), 1.17-1.12 (m, 9H).

Example No. I.1-103

[0299] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (s, 1H), 4.19 (q, 2H), 2.68 (br. s, 1H, OH), 2.48 (sept, 1H), 2.29 (q, 2H), 1.45 (m, 1H), 1.43 (m, 1H), 1.32 (m, 1H), 1.29 (t, 3H), 1.22 (m, 1H), 1.16-1.11 (m, 9H).

Example No. I.1-120

[0300] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.67 (s, 1H), 3.82 (s, 3H), 2.55 (br. s, 1H, OH), 2.51 (sept, 1H), 1.41 (m, 2H), 1.38 (m, 1H), 1.27 (m, 1H), 1.18 (d, 3H), 1.13 (d, 3H).

Example No. I.1-135

[0301] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (s, 1H), 3.72 (s, 3H), 2.66 (br. s, 1H, OH), 2.46 (sept, 1H), 2.03 (s, 3H), 1.44 (m, 1H), 1.42 (m, 1H), 1.33 (m, 1H), 1.21 (m, 1H), 1.13 (d, 3H), 1.11 (d, 3H).

Example No. I.1-136

[0302] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.02 (s, 1H), 4.18 (q, 2H), 2.68 (br. s, 1H, OH), 2.48 (sept, 1H), 2.02 (s, 3H), 1.43 (m, 2H), 1.31 (m, 1H), 1.28 (t, 3H), 1.21 (m, 1H), 1.14 (d, 3H), 1.12 (d, 3H).

Example No. I.1-158

[0303] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 5.95 (s, 1H), 5.82 (br. s, 1H, NH), 4.12 (m, 1H), 2.88 (br.s, 1H, OH), 2.46 (sept, 1H), 2.27 (br. q, 2H), 1.42 (m, 1H), 1.33 (m, 1H), 1.26 (m, 2H), 1.18 (d, 6H), 1.14 (d, 3H), 1.13 (t, 3H), 1.11 (d, 3H).

Example No. I.1-202

[0304] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.76 (m, 2H), 7.43-7.35 (m, 3H), 6.07 (s, 1H), 3.72 (s, 3H), 3.35 (br. s, 1H, OH), 2.34 (q, 2H), 1.60 (m, 1H), 1.57 (m, 1H), 1.28 (m, 2H), 1.18 (t, 3H).

Example No. I.1-203

[0305] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.75 (m, 2H), 7.42-7.34 (m, 3H), 6.07 (s, 1H), 4.20 (q, 2H), 3.55 (br. s, 1H, OH), 2.34 (q, 2H), 1.62 (m, 1H), 1.56 (m, 1H), 1.28 (t, 3H), 1.26 (m, 2H), 1.18 (t, 3H).

Example No. I.1-220

[0306] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (m, 2H), 7.44-7.37 (m, 3H), 6.71 (s, 1H), 3.83 (s, 2H), 3.09 (br. s, 1H, OH), 1.61 (m, 1H), 1.50 (m, 1H), 1.32 (m, 2H).

Example No. I.1-502

[0307] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.75 (m, 2H), 7.10 (m, 2H), 6.09 (s, 1H), 3.73 (s, 3H), 3.42 (br. s, 1H, OH), 2.35 (q, 2H), 1.58 (m, 1H), 1.56 (m, 1H), 1.29 (m, 2H), 1.17 (t, 3H).

Example No. I.1-520

[0308] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (m, 2H), 7.12 (m, 2H), 6.73 (s, 1H), 3.83 (s, 3H), 3.12 (br. s, 1H, OH), 1.60 (m, 1H), 1.49 (m, 1H), 1.33 (m, 1H), 1.31 (m, 1H).

Example No. I.1-557

[0309] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (m, 2H), 7.55 (br. m, 1H, NH), 7.11 (m, 2H), 7.03 (s, 1H), 2.94 (m, 1H), 2.49 (q, 2H), 2.28 (br.s, 1H, OH), 1.48 (m, 2H), 1.42 (m, 2H), 1.38 (m, 2H), 1.27 (t, 3H), 1.12 (m, 2H).

Example No. I.1-558

[0310] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (m, 2H), 7.11 (m, 2H), 6.23 (s, 1H), 5.53 (br. m, 1H, NH), 4.18 (m, 1H), 2.63 (q, 2H), 2.37 (br.s, 1H, OH), 1.43 (m, 2H), 1.38 (m, 2H), 1.20 (d, 3H), 1.18 (d, 3H), 1.13 (t, 3H).

Example No. I.1-605

[0311] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.04 (s, 1H), 4.08 (t, 2H), 2.75 (br. s, 1H, OH), 2.47 (sept, 1H), 2.30 (q, 2H), 1.68 (sext, 2H), 1.45 (m, 2H), 1.43 (m, 1H), 1.31 (m, 1H), 1.17-1.11 (m, 9H), 0.95 (t, 3H).

Example No. I.1-608

[0312] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.68 (s, 1H), 4.17 (t, 2H), 2.52 (br. s, 1H, OH), 2.48 (sept, 1H), 1.71 (sext, 2H), 1.41 (m, 2H), 1.38 (m, 1H), 1.27 (m, 1H), 1.16 (d, 3H), 1.13 (d, 3H), 0.97 (t, 3H).

Example No. I.1-609

[0313] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.75 (m, 2H), 7.43-7.36 (m, 3H), 6.08 (s, 1H), 4.09 (t, 2H), 3.42 (br. s, 1H, OH), 2.37 (q, 2H), 1.68 (sext, 2H), 1.61 (m, 1H), 1.57 (m, 1H), 1.27 (m, 2H), 1.18 (t, 3H), 0.96 (t, 3H).

Example No. I.1-610

[0314] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (m, 2H), 7.42-7.36 (m, 3H), 6.06 (s, 1H), 4.58 (br. s, 1H, OH), 4.29 (m, 2H), 3.63 (m, 1H), 3.58 (m, 1H), 3.31 (s, 3H), 2.39 (q, 2H), 1.53 (m, 1H), 1.44 (m, 1H), 1.24 (m, 2H), 1.20 (t, 3H).

Example No. I.1-613

[0315] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.75 (m, 2H), 7.09 (m, 2H), 6.09 (s, 1H), 4.09 (t, 2H), 3.49 (br. s, 1H, OH), 2.37 (q, 2H), 1.68 (sext, 2H), 1.58 (m, 1H), 1.54 (m, 1H), 1.29 (m, 2H), 1.18 (t, 3H), 0.97 (t, 3H).

Example No. I.1-614

[0316] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.72 (m, 2H), 7.10 (m, 2H), 6.07 (s, 1H), 4.61 (br. s, 1H, OH), 4.30 (m, 2H), 3.67-3.60 (m, 2H), 3.32 (s, 3H), 2.38 (q, 2H), 1.53 (m, 1H), 1.44 (m, 1H), 1.25 (m, 2H), 1.20 (t, 3H).

Example No. I.1-616

[0317] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (m, 2H), 7.11 (m, 2H), 6.73 (s, 1H), 4.18 (t, 2H), 3.12 (br. s, 1H, OH), 1.70 (sext, 2H), 1.58 (m, 1H), 1.49 (m, 1H), 1.32 (m, 2H), 0.96 (t, 3H).

Example No. I.1-618

[0318] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.02 (s, 1H), 3.73 (s, 3H), 2.73 (br. s, 1H, OH), 2.29 (q, 2H), 1.53 (m, 1H), 1.46 (m, 1H), 1.36 (m, 1H), 1.24 (m, 2H), 1.14 (t, 3H), 0.79 (m, 1H), 0.72 (m, 2H), 0.62 (m, 1H).

Example No. I.1-632

[0319] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.66 (s, 1H), 3.83 (s, 3H), 3.51 (br. s, 1H, OH), 1.58 (m, 1H), 1.46 (m, 1H), 1.33-1.25 (m, 3H), 0.81-0.73 (m, 2H), 0.71-0.63 (m, 2H).

Example No. I.1-648

[0320] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.05 (s, 1H), 3.73 (s, 3H), 3.07 (m, 1H), 2.78 (br. s, 1H, OH), 2.33 (q, 2H), 2.24 (m, 1H), 2.13-2.05 (m, 3H), 1.93 (m, 1H), 1.78 (m, 1H), 1.42 (m, 1H), 1.34 (m, 1H), 1.21 (m, 5H).

Example No. I.1-662

[0321] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.69 (s, 1H), 3.83 (s, 3H), 3.10 (m, 1H), 2.53 (br. s, 1H, OH), 2.28 (m, 1H), 2.13-2.06 (m, 3H), 1.95 (m, 1H), 1.41 (m, 1H), 1.30 (m, 1H), 1.24-1.18 (m, 2H).

Example No. I.1-678

[0322] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.02 (s, 1H), 3.72 (s, 3H), 2.68 (br. s, 1H, OH), 2.31 (q, 2H), 2.11 (m, 2H), 2.02 (m, 1H), 1.82 (m, 2H), 1.72 (m, 1H), 1.45-1.38 (m, 3H), 1.32-1.28 (m, 3H), 1.22-1.16 (m, 4H), 1.14 (t, 3H).

Example No. I.1-692

[0323] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.66 (s, 1H), 3.82 (s, 3H), 2.54 (br. s, 1H, OH), 2.17 (m, 1H), 2.10 (m, 1H), 2.02 (m, 1H), 1.83 (m, 2H), 1.72 (m, 1H), 1.41-1.34 (m, 6H), 1.32-1.22 (m, 1H), 1.18-1.11 (m, 2H).

Example No. I.1-702

[0324] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.02 (s, 1H), 4.18 (q, 2H), 2.69 (br. s, 1H, OH), 2.10 (m, 2H), 2.02 (s, 3H), 1.98 (m, 1H), 1.82 (m, 2H), 1.71 (m, 1H), 1.42 (m, 2H), 1.38 (m, 1H), 1.32-1.26 (m, 2H), 1.29 (t, 3H), 1.21-1.14 (m, 4H).

Example No. I.1-711

[0325] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.02 (s, 1H), 4.31 (m, 2H), 3.67 (m, 2H), 3.58 (br. s, 1H, OH), 3.41 (s, 1H), 2.28 (q, 2H), 1.97 (m, 1H), 1.88 (m, 1H), 1.78 (m, 1H), 1.51-1.42 (m, 3H), 1.38-1.29 (m, 2H), 1.21 (m, 1H), 1.14 (t, 3H), 1.04 (m, 6H).

Example No. I.1-722

[0326] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.65 (s, 1H), 3.82 (s, 3H), 2.49 (br. s, 1H, OH), 2.03 (m, 1H), 1.88 (m, 1H), 1.78 (m, 1H), 1.51 (m, 1H), 1.45-1.38 (m, 4H), 1.27 (m, 1H), 1.05 (m, 6H).

Example No. I.1-723

[0327] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.65 (s, 1H), 4.28 (q, 2H), 2.51 (br. s, 1H, OH), 2.03 (m, 1H), 1.87 (m, 1H), 1.76 (m, 1H), 1.51-1.38 (m, 4H), 1.33 (t, 3H), 1.27 (m, 2H), 1.06 (m, 6H).

Example No. I.1-732

[0328] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.01 (s, 1H), 4.18 (q, 2H), 2.65 (br. s, 1H, OH), 2.03 (s, 3H), 1.99 (m, 1H), 1.87 (m, 1H), 1.78 (m, 1H), 1.53-1.39 (m, 4H), 1.33 (m, 1H), 1.28 (t, 3H), 1.22 (m, 1H), 1.04 (m, 6H).

Example No. I.1-738

[0329] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.04 (s, 1H), 3.72 (s, 3H), 2.74 (br. s, 1H, OH), 2.34 (q, 2H), 2.08 (m, 4H), 1.97 (m, 4H), 1.94 (m, 1H), 1.72 (m, 6H), 1.55 (m, 1H), 1.38 (m, 1H), 1.29-1.20 (m, 2H), 1.19 (t, 3H).

Example No. I.1-752

[0330] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.67 (s, 1H), 3.83 (s, 3H), 2.45 (br. s, 1H, OH), 2.09 (m, 4H), 1.97 (m, 4H), 1.72 (m, 7H), 1.58 (m, 1H), 1.42 (m, 1H), 1.33-1.22 (m, 2H).

Example No. I.1-753

[0331] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.67 (s, 1H), 4.29 (q, 2H), 2.50 (br. s, 1H, OH), 2.09 (m, 3H), 1.98 (m, 5H), 1.92 (m, 1H), 1.71 (m, 6H), 1.58 (m, 1H), 1.33 (m, 4H), 1.25-1.20 (m, 2H).

Example No. I.1-762

[0332] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (s, 1H), 4.18 (q, 2H), 2.80 (br. s, 1H, OH), 2.07 (m, 4H), 1.98 (m, 4H), 1.71 (m, 6H), 1.68 (m, 1H), 1.55 (m, 1H), 1.38 (m, 1H), 1.27 t, 3H), 1.21 (m, 2H).

Example No. I.1-768

[0333] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.56 (m, 1H), 7.48 (m, 1H), 7.39 (m, 1H), 7.07 (m, 1H), 6.09 (s, 1H), 3.73 (s, 3H), 3.58 (br. s, 1H, OH), 2.37 (q, 2H), 1.61-1.55 (m, 2H), 1.31-1.27 (m, 2H), 1.19 (t, 3H).

Example No. I.1-771

[0334] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.54 (m, 1H), 7.45-7.37 (m, 2H), 7.06 (m, 1H), 6.07 (s, 1H), 4.71 (br. s, 1H, OH), 4.30 (t, 2H), 3.65-3.58 (m, 2H), 3.33 (s, 3H), 2.39 (q, 2H), 1.54 (m, 1H), 1.47 (m, 1H), 1.28-1.25 (m, 2H), 1.21 (t, 3H).

Example No. I.1-782

[0335] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.55 (m, 1H), 7.47-7.39 (m, 2H), 7.11-7.07 (m, 1H), 6.73 (s, 1H), 3.84 (s, 3H), 3.19 (br. s, 1H, OH), 1.60 (m, 1H), 1.52 (m, 1H), 1.36-1.30 (m, 2H).

Example No. I.1-783

[0336] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.54 (m, 1H), 7.46-7.39 (m, 2H), 7.10-7.06 (m, 1H), 6.73 (s, 1H), 4.20 (q, 2H), 3.19 (br. s, 1H, OH), 1.60-1.53 (m, 2H), 1.31-1.24 (m, 5H).

Example No. I.1-792

[0337] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.56 (m, 1H), 7.46 (m, 1H), 7.39 (m, 1H), 7.09-7.05 (m, 1H), 6.09 (s, 1H), 4.20 (q, 2H), 3.57 (br. s, 1H, OH), 2.07 (s, 3H), 1.59 (m, 2H), 1.30-1.25 (m, 5H).

Example No. I.1-798

[0338] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.64 (d, 2H), 7.22 (d, 2H), 6.06 (s, 1H), 3.73 (s, 3H), 3.18 (br. s, 1H, OH), 2.37 (s, 3H), 2.32 (q, 2H), 1.58 (m, 1H), 1.54 (m, 1H), 1.29-1.25 (m, 2H), 1.16 (t, 3H).

Example No. I.1-801

[0339] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.61 (d, 2H), 7.22 (d, 2H), 6.05 (s, 1H), 4.48 (br. s, 1H, OH), 4.29 (m, 2H), 3.67-3.57 (m, 2H), 3.32 (s, 3H), 2.40-2.34 (m, 5H), 1.53 (m, 1H), 1.44 (m, 1H), 1.24 (m, 2H), 1.20 (t, 3H).

Example No. I.1-812

[0340] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.61 (d, 2H), 7.24 (d, 2H), 6.71 (s, 1H), 3.83 (s, 3H), 2.93 (br. s, 1H, OH), 2.38 (s, 3H), 1.58 (m, 1H), 1.46 (m, 1H), 1.33-1.28 (m, 2H).

Example No. I.1-813

[0341] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.61 (d, 2H), 7.22 (d, 2H), 6.70 (s, 1H), 4.29 (q, 2H), 2.99 (br. s, 1H, OH), 2.37 (s, 3H), 1.58 (m, 1H), 1.44 (m, 1H), 1.34-1.27 (m, 5H).

Example No. I.1-822

[0342] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.63 (d, 2H), 7.23 (d, 2H), 6.06 (s, 1H), 4.19 (q, 2H), 3.28 (br. s, 1H, OH), 2.37 (s, 3H), 1.57 (m, 1H), 1.54 (m, 1H), 1.29-1.22 (m, 5H).

Example No. I.1-831

[0343] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (s, 1H), 4.31 (m, 2H), 3.67 (m, 2H), 3.82 (s, 3H), 3.59 (br. s, 1H, OH), 3.41 (s, 3H), 2.72-2.66 (m, 1H), 2.28 (q, 2H), 1.96-1.89 (m, 2H), 1.72-1.56 (m, 6H), 1.42 (m, 1H), 1.32 (m, 1H), 1.25-1.18 (m, 2H), 1.14 (t, 3H).

Example No. I.1-842

[0344] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.66 (s, 1H), 3.82 (s, 3H), 2.73 (m, 1H), 2.50 (br. s, 1H, OH), 1.98-1.91 (m, 2H), 1.73-1.60 (m, 6H), 1.46-1.30 (m, 3H), 1.28-1.24 (m, 1H).

Example No. I.1-851

[0345] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (s, 1H), 3.72 (s, 3H), 2.71 (m, 1H), 2.58 (br. s, 1H, OH), 2.02 (s, 3H), 1.97-1.90 (m, 2H), 1.72-1.59 (m, 6H), 1.47-1.41 (m, 2H), 1.28 (m, 1H), 1.21 (m, 1H).

Example No. I.1-858

[0346] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.04 (s, 1H), 3.72 (s, 3H), 2.70 (br. s, 1H, OH), 2.33 (q, 2H), 1.59-1.55 (m, 1H), 1.43-1.39 (m, 1H), 1.25 (s, 9H), 1.23 (m, 2H).

Example No. I.1-872

[0347] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.67 (s, 1H), 3.83 (s, 3H), 2.47 (br. s, 1H, OH), 1.59-1.56 (m, 1H), 1.41-1.32 (m, 2H), 1.25 (s, 9H), 1.23 (m, 1H).

Example No. I.1-881

[0348] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.04 (s, 1H), 3.72 (s, 3H), 2.72 (br. s, 1H, OH), 2.05 (s, 3H), 1.59-1.55 (m, 1H), 1.43-1.40 (m, 1H), 1.25 (s, 9H), 1.23 (m, 2H).

Example No. I.1-887

[0349] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.66 (s, 1H), 4.17 (t, 2H), 2.50 (br. s, 1H, OH), 2.03 (m, 1H), 1.85 (m, 1H), 1.78 (m, 1H), 1.72 (sext, 2H), 1.49-1.37 (m, 4H), 1.27 (m, 2H), 1.05 (m, 6H), 0.98 (t, 3H).

Example No. I.1-888

[0350] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.62 (d, 2H), 7.22 (d, 2H), 6.71 (s, 1H), 4.17 (t, 2H), 3.07 (br. s, 1H, OH), 2.37 (s, 3H), 1.73-1.67 (m, 2H), 1.59 (m, 1H), 1.47 (m, 1H), 1.32-1.27 (m, 2H), 0.96 (t, 3H).

Example No. I.1-889

[0351] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.68 (s, 1H), 4.17 (t, 2H), 2.49 (br. s, 1H, OH), 1.73-1.67 (m, 2H), 1.59 (m, 1H), 1.39-1.30 (m, 2H), 1.26 (s, 9H), 1.24 (m, 1H), 0.97 (t, 3H).

Example No. I.1-890

[0352] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.67 (s, 1H), 4.17 (t, 2H), 2.72 (m, 1H), 2.49 (br. s, 1H, OH), 1.98-1.90 (m, 2H), 1.74-1.60 (m, 8H), 1.46-1.38 (m, 2H), 1.32 (m, 1H), 1.24 (m, 1H), 0.97 (t, 3H).

Example No. I.1-892

[0353] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.71 (d, 2H), 7.40 (d, 2H), 6.09 (s, 1H), 3.73 (s, 3H), 3.24 (br. s, 1H, OH), 2.36 (q, 2H), 1.59-1.55 (m, 2H), 1.32-1.26 (m, 2H), 1.16 (t, 3H).

Example No. I.1-906

[0354] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.69 (d, 2H), 7.42 (d, 2H), 6.73 (s, 1H), 3.83 (s, 2H), 2.98 (br. s, 1H, OH), 1.59 (m, 1H), 1.47 (m, 1H), 1.34-1.28 (m, 2H).

Example No. I.1-916

[0355] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.71 (d, 2H), 7.40 (d, 2H), 6.09 (s, 1H), 4.19 (q, 2H), 3.25 (br. s, 1H, OH), 2.05 (s, 3H), 1.59-1.55 (m, 2H), 1.32-1.24 (m, 5H).

Example No. I.1-921

[0356] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.69 (d, 2H), 7.41 (d, 2H), 6.73 (s, 1H), 4.17 (t, 2H), 3.05 (br. s, 1H, OH), 1.73-1.66 (m, 2H), 1.59 (m, 1H), 1.49 (m, 1H), 1.34-1.28 (m, 2H), 0.97 (t, 3H).

Example No. I.2-102

[0357] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.68 (d, 1H), 6.26 (d, 1H), 5.74 (s, 1H), 3.72 (s, 3H), 2.94 (br. s, 1H, OH), 2.41 (q, 2H), 2.37 (sept, 1H), 1.34 (m, 1H), 1.19 (m, 1H), 1.14 (t, 3H), 1.07 (d, 3H), 1.03 (m, 1H), 0.96 (m, 1H), 0.92 (d, 3H).

Example No. I.2-130

[0358] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.67 (d, 1H), 6.23 (d, 1H), 5.75 (s, 1H), 4.17 (q, 2H), 2.95 (m, 1H), 2.39 (sept, 1H), 1.94 (m, 2H), 1.73 (m, 1H), 1.68 (m, 2H), 1.63 (br. s, 1H, OH), 1.51 (m, 2H), 1.44 (m, 2H), 1.30 (t, 3H), 1.20 (m, 1H), 1.07 (d, 3H), 1.05 (m, 1H), 0.98 (m, 1H), 0.93 (d, 3H).

Example No. I.2-134

[0359] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (d, 1H), 6.29 (d, 1H), 5.77 (s, 1H), 2.38 (sept, 1H), 2.08 (s, 3H), 1.68 (br. s, 1H, OH), 1.33 (m, 1H), 1.22 (m, 1H), 1.07 (d, 3H), 1.03 (m, 1H), 0.96 (m, 1H), 0.93 (d, 3H).

Example No. I.2-507

[0360] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.68 (d, 1H), 6.25 (d, 1H), 5.74 (s, 1H), 4.09 (t, 2H), 2.42 (q, 2H), 2.38 (sept, 1H), 1.68 (sext, 2H), 1.58 (br. s, 1H, OH), 1.39 (m, 1H), 1.34 (m, 1H), 1.20 (m, 1H), 1.16 (t, 3H), 1.06 (d, 3H), 1.02 (m, 1H), 0.97 (d, 3H), 0.93 (t, 3H).

Example No. I.2-581

[0361] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.44 (d, 1H), 6.36 (d, 1H), 6.31 (s, 1H), 3.79 (s, 3H), 2.08-1.99 (m, 2H), 1.88-1.75 (m, 2H), 1.71 (m, 2H), 1.62 (br. s, 1H, OH), 1.39-1.28 (m, 4H), 1.25-1.18 (m, 2H), 1.09 (m, 1H), 1.05-0.92 (m, 2H).

Example No. I.2-582

[0362] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.45 (d, 1H), 6.34 (d, 1H), 6.30 (s, 1H), 4.15 (t, 2H), 2.09-1.98 (m, 2H), 1.87-1.76 (m, 3H), 1.72 (sext, 2H), 1.64 (br. s, 1H, OH), 1.39-1.28 (m, 3H), 1.25-1.17 (m, 2H), 1.08 (m, 3H), 0.98 (t, 3H), 0.94 (m, 2H).

Example No. I.2-583

[0363] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.67 (d, 1H), 6.24 (d, 1H), 5.73 (s, 1H), 3.72 (s, 3H), 2.41 (q, 2H), 1.89 (m, 1H), 1.79 (m, 1H), 1.63 (m, 1H), 1.59 (br. s, 1H, OH), 1.41-1.32 (m, 3H), 1.31-1.22 (m, 3H) 1.13 (t, 3H), 1.04 (t, 3H), 0.97 (t, 3H).

Example No. I.2-586

[0364] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.46 (d, 1H), 6.34 (d, 1H), 6.31 (s, 1H), 4.17 (t, 2H), 1.91 (m, 1H), 1.78 (m, 1H), 1.70 (sext, 2H), 1.61 (m, 1H), 1.59 (br. s, 1H, OH), 1.37 (m, 1H), 1.33-1.22 (m, 4H) 1.12 (m, 1H), 1.03 (t, 3H), 1.00-0.91 (m, 6H).

Example No. I.2-591

[0365] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.94 (d, 1H), 7.46 (d, 2H), 7.21 (d, 2H), 6.54 (d, 1H), 5.78 (s, 1H), 3.71 (s, 3H), 2.45 (q, 2H), 2.36 (s, 3H), 2.15 (br. s, 1H, OH), 1.42-1.38 (m, 1H), 1.34-1.21 (m, 3H), 1.17 (t, 3H).

Example No. I.2-593

[0366] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.70 (d, 1H), 7.44 (d, 2H), 7.23 (d, 2H), 6.69 (d, 1H), 6.37 (s, 1H), 3.79 (s, 3H), 2.36 (s, 3H), 2.12 (br. s, 1H, OH), 1.42-1.37 (m, 1H), 1.36-1.26 (m, 2H), 1.23-1.18 (m, 1H).

Example No. I.2-599

[0367] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.70 (d, 1H), 6.32 (d, 1H), 5.74 (s, 1H), 3.72 (s, 3H), 2.65-2.58 (m, 1H), 2.44-2.38 (q, 2H), 1.92-1.85 (m, 1H), 1.72-1.55 (m, 8H), 1.35-1.28 (m, 2H) 1.14 (t, 3H), 1.02 (m, 2H).

Example No. I.2-601

[0368] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.47 (d, 1H), 6.42 (d, 1H), 6.32 (s, 1H), 3.80 (s, 3H), 2.70-2.63 (m, 1H), 1.95-1.88 (m, 1H), 1.81-1.73 (m, 1), 1.68-1.58 (m, 4H), 1.52 (br. s, 1H, OH), 1.47-1.38 (m, 2H), 1.29 (m, 1H) 1.18 (m, 1H), 1.10 (m, 1H), 1.02 (m, 2H).

Example No. I.2-603

[0369] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.69 (d, 1H), 6.64 (d, 1H), 5.76 (s, 1H), 3.71 (s, 3H), 2.46 (q, 2H), 1.61 (br. s, 1H, OH), 1.44-1.39 (m, 1H), 1.31-1.27 (m, 1H), 1.15 (s, 9H), 1.12-1.08 (m, 1H), 0.97-0.93 (m, 1H).

Example No. I.2-605

[0370] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.48 (d, 1H), 6.72 (d, 1H), 6.33 (s, 1H), 3.80 (s, 3H), 1.67 (m, 1H), 1.62 (br. s, 1H, OH), 1.40-1.26 (m, 2H), 1.16 (s, 9H), 1.12-1.04 (m, 1H).

Example No. I.2-615

[0371] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.76 (d, 1H), 6.23 (d, 1H), 5.74 (s, 1H), 4.17 (q, 2H), 2.03 (s, 3H), 1.86 (m, 1H), 1.80 (m, 1H), 1.63 (m, 1H), 1.59 (br. s, 1H, OH), 1.41-1.33 (m, 3H), 1.32-1.21 (m, 6H) 1.04 (t, 3H), 0.96 (t, 3H).

Example No. I.2-616

[0372] 7.75 (d, 1H), 6.24 (d, 1H), 5.73 (s, 1H), 4.17 (q, 2H), 2.04 (s, 3H), 2.03-1.95 (m, 2H), 1.80 (m, 2H), 1.71 (m, 2H), 1.62 (br. s, 1H, OH), 1.42-1.30 (m, 4H), 1.28 (t, 3H), 1.20-1.16 (m, 1H), 1.14-1.08 (m, 1H), 1.04-0.92 (m, 3H).

Example No. I.2-617

[0373] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 8.04 (d, 1H), 7.46 (d, 2H), 7.22 (d, 2H), 6.51 (d, 1H), 5.79 (s, 1H), 4.17 (q, 2H), 2.36 (s, 3H), 2.12 (br. s, 1H, OH), 2.07 (s, 3H), 1.41-1.37 (m, 1H), 1.35-1.22 (m, 6H).

Example No. I.2-619

[0374] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.81 (d, 1H), 6.61 (d, 1H), 5.76 (s, 1H), 4.16 (q, 2H), 2.07 (s, 3H), 1.62 (br. s, 1H, OH), 1.42-1.35 (m, 2H), 1.29 (t, 3H), 1.15 (s, 9H), 1.10 (m, 1H), 0.97-0.92 (m, 1H).

Example No. I.2-620

[0375] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.48 (d, 1H), 6.71 (d, 1H), 6.33 (s, 1H), 4.26 (q, 2H), 1.63 (br. s, 1H, OH), 1.39-1.24 (m, 5H), 1.15 (s, 9H), 1.12-1.04 (m, 2H).

Example No. I.3-23

[0376] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.07 (s, 1H), 3.73 (s, 3H), 2.83-2.71 (m, 2H), 2.63 (br. s, 1H, OH), 2.41-2.25 (m, 6H), 1.92 (m, 1H), 1.19 (t, 3H), 1.11 (d, 3H), 1.04 (d, 3H).

Example No. I.3-33

[0377] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.71 (s, 1H), 4.29 (q, 2H), 2.80-2.68 (m, 2H), 2.44 (br. s, 1H, OH), 2.40 (m, 4H), 2.30 (m, 2H), 1.95 (m, 1H), 1.33 (t, 3H), 1.13 (d, 3H), 1.02 (d, 3H).

Example No. I.3-39

[0378] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.07 (s, 1H), 4.19 (q, 2H), 2.81-2.72 (m, 2H), 2.77 (br. s, 1H, OH), 2.41-2.25 (m, 4H), 2.08 (s, 3H), 1.92 (m, 1H), 1.28 (t, 3H), 1.10 (d, 3H), 1.03 (d, 3H).

Example No. I.3-53

[0379] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.73 (m, 2H), 7.42-7.36 (m, 3H), 6.73 (s, 1H), 3.83 (q, 2H), 3.04 (br. s, 1H, OH), 2.87-2.772 (m, 2H), 2.35-2.27 (m, 2H), 2.25-2.17 (m, 1H), 1.97-1.89 (m, 1H).

Example No. I.3-60

[0380] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.75 (m, 2H), 7.41-7.34 (m, 3H), 6.10 (s, 1H), 4.20 (q, 2H), 3.29 (br. s, 1H, OH), 2.85-2.76 (m, 2H), 2.32-2.25 (m, 2H), 2.23-2.14 (m, 1H), 2.10 (s, 3H), 1.96-1.88 (m, 1H), 1.27 (t, 3H).

Example No. I.3-128

[0381] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.07 (s, 1H), 4.32 (m, 2H), 3.67 (m, 2H), 3.40 (s, 3H), 3.61 (br. s, 1H, OH), 2.80-2.66 (m, 2H), 2.40-2.24 (m, 6H), 1.90 (m, 1H), 1.20 (t, 3H), 1.08 (d, 3H), 1.02 (d, 3H).

Example No. I.3-132

[0382] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.72 (s, 1H), 4.18 (t, 2H), 2.81-2.69 (m, 2H), 2.43 (br. s, 1H, OH), 2.42-2.34 (m, 4H), 2.32 (m, 2H), 1.97-1.92 (m, 1H), 1.71 (sext, 2H), 1.12 (d, 3H), 1.02 (d, 3H), 0.97 (t, 3H).

Example No. 1.4-23

[0383] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.76 (d, 1H), 6.09 (d, 1H), 5.73 (s, 1H), 3.72 (s, 3H), 2.73 (m, 1H), 2.41 (m, 1H), 2.38 (m, 2H), 2.29-2.18 (m, 3H), 2.03 (m, 1H), 1.82 (br. s, 1H, OH), 1.80 (m, 1H), 1.12 (t, 3H), 0.94 (d, 3H), 0.89 (d, 3H).

Example No. 1.4-39

[0384] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.86 (d, 1H), 6.07 (d, 1H), 5.73 (s, 1H), 4.19 (q, 2H), 2.73 (m, 1H), 2.41 (m, 1H), 2.29-2.18 (m, 3H), 2.02 (s, 3H), 1.83 (br. s, 1H, OH), 1.79 (m, 1H), 1.68 (m, 1H), 1.29 (t, 3H), 0.94 (d, 3H), 0.89 (d, 3H).

Example No. II.1-8

[0385] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.51 (m, 1H), 7.42-7.38 (m, 2H), 7.11-7.07 (m, 1H), 2.79 (s, 1H), 2.73 (br. s, 1H, OH), 1.52 (m, 1H), 1.45-1.37 (m, 1H), 1.32-1.27 (m, 2H).

Example No. II.1-9

[0386] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.66 (d, 2H), 7.42 (d, 2H), 2.79 (s, 1H), 2.66 (br. s, 1H, OH), 1.50 (m, 1H), 1.40 (m, 1H), 1.32-1.25 (m, 2H).

Example No. II.1-11

[0387] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.60 (d, 2H), 7.22 (d, 2H), 2.76 (s, 1H), 2.58 (br. s, 1H, OH), 2.38 (s, 3H), 1.50 (m, 1H), 1.38 (m, 1H), 1.28 (m, 2H).

Example No. II.1-79

[0388] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.69 (m, 1H), 7.49 (m, 1H), 7.33 (m, 1H), 2.77 (s, 1H), 2.64 (br. s, 1H, OH), 1.48 (m, 1H), 1.35 (m, 1H), 1.28 (m, 2H).

Example No. II.1-80

[0389] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 3.04 (m, 1H), 2.77 (s, 1H), 2.21 (m, 1H), 2.09 (br. s, 1H, OH), 2.07 (m, 2H), 1.93 (m, 1H), 1.78 (m, 1H), 1.31 (m, 1H), 1.24-1.15 (m, 4H).

Example No. II.1-82

[0390] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 2.48 (m, 1H), 2.18 (br. s, 1H, OH), 2.11-1.94 (m, 3H), 1.86-1.78 (m, 2H), 1.74-1.68 (m, 1H), 1.42-1.23 (m, 5H), 1.21-1.08 (m, 4H).

Example No. II.1-83

[0391] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 3.38 (m, 1H), 3.29 (m, 1H), 2.82 (m, 1H), 2.56 (br. s, 1H, OH), 2.11-2.03 (m, 4H), 2.01-1.78 (m, 3H), 1.87 (m, 1H), 1.83 (m, 1H), 1.76-1.65 (m, 4H), 1.48-1.43 (m, 2H), 1.31-1.16 (m, 2H).

Example No. II.1-85

[0392] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 2.56 (s, 1H), 2.04 (br. s, 1H, OH), 1.54-1.47 (m, 2H), 1.33-1.25 (m, 2H), 1.24 (s, 9H).

Example No. III.1-3

[0393] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.71 (m, 2H), 7.57 (m, 1H), 7.39 (m, 2H), 6.57 (d, 1H), 6.18 (d, 1H), 2.08 (br. s, 1H, OH), 1.48 (m, 2H), 1.41-1.36 (m, 12H), 1.31-1.19 (m, 15H), 1.09 (m, 2H).

Example No. III.1-66

[0394] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.03 (d, 1H), 5.93 (d, 1H), 1.83 (m, 2H), 1.68 (m, 2H), 1.58 (m, 1H), 1.42 (br. s, 1H, OH), 1.41-1.32 (m, 4H), 1.22-1.13 (m, 9H), 1.09 (m, 1H), 1.04-0.99 (m, 2H), 0.95 (m, 1H), 0.88 (m, 2H), 0.82-0.73 (m, 17H), 0.69 (m, 1H).

Example No. III.1-73

[0395] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 7.45 (d, 2H), 7.19 (d, 2H), 6.46 (d, 1H), 6.35 (d, 1H), 2.35 (s, 3H), 2.01 (br. s, 1H, OH), 1.52 (m, 2H), 1.37-1.20 (m, 12H), 0.96-0.84 (m, 15H), 0.74 (m, 2H).

Example No. III.1-75

[0396] .sup.1H NMR (400 MHz, CDCl.sub.3 , ppm) 6.48 (d, 1H), 6.14 (d, 1H), 1.58 (br. s, 1H, OH), 1.52 (m, 2H), 1.37-1.20 (m, 12H), 1.11 (s, 9H), 0.96-0.84 (m, 15H), 0.74 (m, 2H).

[0397] The present invention further provides for the use of at least one inventive compound selected from the group consisting of substituted cyanocycloalkylpenta-2,4-dienes and cyanocycloalkylpent-2-en-4-ynes of the general formula (I), and of any desired mixtures of these inventive substituted cyanocycloalkylpenta-2,4-dienes, cyanocycloalkylpent-2-en-4-ynes, cyanoheterocyclylpenta-2,4-dienes and cyanoheterocyclylpent-2-en-4-ynes of the general formula (I) with further active agrochemical ingredients for enhancing the resistance of plants to abiotic stress factors, preferably drought stress, and for enhancing plant growth and/or for increasing plant yield.

[0398] The present invention further provides a spray solution for treatment of plants, comprising an amount, effective for enhancing the resistance of plants to abiotic stress factors, of at least one compound selected from the group consisting of the inventive substituted cyanocycloalkylpenta-2,4-dienes and cyanocycloalkylpent-2-en-4-ynes of the general formula (I). The abiotic stress conditions which can be relativized may include, for example, heat, drought, cold and aridity stress (stress caused by aridity and/or lack of water), osmotic stress, waterlogging, elevated soil salinity, elevated exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients.

[0399] In one embodiment, it is possible, for example, that the compounds envisaged in accordance with the invention, i.e. the appropriate inventive substituted cyanocycloalkylpenta-2,4-dienes, cyanocycloalkylpent-2-en-4-ynes, cyanoheterocyclylpenta-2,4-dienes and cyanoheterocyclylpent-2-en-4-ynes of the general formula (I), are applied by spray application to appropriate plants or plant parts to be treated. The compounds of the general formula (I) or salts thereof are used as envisaged in accordance with the invention preferably with a dosage between 0.00005 and 3 kg/ha, more preferably between 0.0001 and 2 kg/ha, especially preferably between 0.0005 and 1 kg/ha, specifically preferably between 0.001 and 0.25 kg/ha. If, in the context of the present invention, abscisic acid is used simultaneously with substituted cyanocycloalkylpenta-2,4-dienes and cyanocycloalkylpent-2-en-4-ynes of the general formula (I), for example in the context of a combined preparation or formulation, the addition of abscisic acid is preferably effected in a dosage between 0.0001 and 3 kg/ha, more preferably between 0.001 and 2 kg/ha, especially preferably between 0.005 and 1 kg/ha, very especially preferably between 0.006 and 0.25 kg/ha.

[0400] The term resistance to abiotic stress is understood in the context of the present invention to mean various kinds of advantages for plants. Such advantageous properties are manifested, for example, in the improved plant characteristics given below: improved root growth with regard to surface area and depth, increased stolon or tiller formation, stronger and more productive stolons and tillers, improvement in shoot growth, increased lodging resistance, increased shoot base diameter, increased leaf area, higher yields of nutrients and constituents, for example carbohydrates, fats, oils, proteins, vitamins, minerals, essential oils, dyes, fibres, better fibre quality, earlier flowering, increased number of flowers, reduced content of toxic products such as mycotoxins, reduced content of residues or disadvantageous constituents of any kind, or better digestibility, improved storage stability of the harvested material, improved tolerance to disadvantageous temperatures, improved tolerance to drought and aridity, and also oxygen deficiency as a result of waterlogging, improved tolerance to elevated salt contents in soil and water, enhanced tolerance to ozone stress, improved compatibility with respect to herbicides and other plant treatment compositions, improved water absorption and photosynthesis performance, advantageous plant properties, for example acceleration of ripening, more homogeneous ripening, greater attractiveness to beneficial animals, improved pollination, or other advantages well known to a person skilled in the art.

[0401] More particularly, the inventive use of one or more inventive compounds of the general formula (I) exhibits the advantages described in spray application to plants and plant parts. Combinations of the inventive substituted cyanocycloalkylpenta-2,4-dienes and cyanocycloalkylpent-2-en-4-ynes of the general formula (I) with substances including insecticides, attractants, acaricides, fungicides, nematicides, herbicides, growth regulators, safeners, substances which influence plant maturity, and bactericides can likewise be employed in the control of plant disorders and/or for increasing the plant yield in the context of the present invention. The combined use of inventive substituted cyanocycloalkylpenta-2,4-dienes and cyanocycloalkylpent-2-en-4-ynes of the general formula (I) with genetically modified cultivars with a view to increased tolerance to abiotic stress is additionally likewise possible.

[0402] The further various benefits for plants mentioned above can be combined in a known manner in component form, and generally applicable terms can be used to describe them. Such terms are, for example, the following names: phytotonic effect, resistance to stress factors, less plant stress, plant health, healthy plants, plant fitness, plant wellness, plant concept, vigor effect, stress shield, protective shield, crop health, crop health properties, crop health products, crop health management, crop health therapy, plant health, plant health properties, plant health products, plant health management, plant health therapy, greening effect or regreening effect, freshness, or other terms with which a person skilled in the art is entirely familiar.

[0403] In the context of the present invention, a good effect on resistance to abiotic stress is understood to mean, without limitation, [0404] at least an emergence improved by generally 3%, especially more than 5%, more preferably more than 10%, [0405] at least a yield enhanced by generally 3%, especially more than 5%, more preferably more than 10%, [0406] at least a root development improved by generally 3%, especially more than 5%, more preferably more than 10%, [0407] at least a shoot size rising by generally 3%, especially more than 5%, more preferably more than 10%, [0408] at least a leaf area increased by generally 3%, especially more than 5%, more preferably more than 10%, [0409] at least a photosynthesis performance improved by generally 3%, especially more than 5%, more preferably more than 10%, and/or [0410] at least a flower development improved by generally 3%, especially more than 5%, more preferably more than 10%,

[0411] and the effects may occur individually or else in any combination of two or more effects.

[0412] The present invention further provides a spray solution for treatment of plants, comprising an amount, effective for enhancing the resistance of plants to abiotic stress factors, of at least one compound selected from the group of the inventive substituted cyanocycloalkylpenta-2,4-dienes, cyanocycloalkylpent-2-en-4-ynes, cyanoheterocyclylpenta-2,4-dienes and cyanoheterocyclylpent-2-en-4-ynes of the general formula (I). The spray solution may comprise other customary constituents, such as solvents, formulation auxiliaries, especially water. Further constituents may include active agrochemical ingredients which are described in more detail below.

[0413] The present invention further provides for the use of corresponding spray solutions for increasing the resistance of plants to abiotic stress factors. The remarks which follow apply both to the use according to the invention of one or more inventive compounds of the general formula (I) per se and to the corresponding spray solutions.

[0414] In accordance with the invention, it has additionally been found that the application, to plants or in their environment, of one or more inventive compounds of the general formula (I) in combination with at least one fertilizer as defined further below is possible.

[0415] Fertilizers which can be used in accordance with the invention together with the inventive compounds of the general formula (I) elucidated in detail above are generally organic and inorganic nitrogen compounds, for example ureas, urea/formaldehyde condensation products, amino acids, ammonium salts and ammonium nitrates, potassium salts (preferably chlorides, sulphates, nitrates), salts of phosphoric acid and/or salts of phosphorous acid (preferably potassium salts and ammonium salts). In this context, particular mention should be made of the NPK fertilizers, i.e. fertilizers which contain nitrogen, phosphorus and potassium, calcium ammonium nitrate, i.e. fertilizers which additionally contain calcium, or ammonium sulphate nitrate (general formula (NH.sub.4).sub.2SO.sub.4NH.sub.4NO.sub.3), ammonium phosphate and ammonium sulphate. These fertilizers are common knowledge to those skilled in the art; see also, for example, Ullmann's Encyclopedia of Industrial Chemistry, 5th edition, Vol. A 10, pages 323 to 431, Verlagsgesellschaft, Weinheim, 1987.

[0416] The fertilizers may additionally comprise salts of micronutrients (preferably calcium, sulphur, boron, manganese, magnesium, iron, boron, copper, zinc, molybdenum and cobalt) and of phytohormones (for example vitamin B1 and indole-3-acetic acid) or mixtures of these. Fertilizers used in accordance with the invention may also contain other salts such as monoammonium phosphate (MAP), diammonium phosphate (DAP), potassium sulphate, potassium chloride, magnesium sulphate. Suitable amounts for the secondary nutrients or trace elements are amounts of 0.5% to 5% by weight, based on the overall fertilizer. Further possible constituents are crop protection agents, insecticides or fungicides, growth regulators or mixtures thereof. Further details of these are given further down.

[0417] The fertilizers can be used, for example, in the form of powders, granules, prills or compactates. However, the fertilizers can also be used in liquid form, dissolved in an aqueous medium. In this case, dilute aqueous ammonia can also be used as a nitrogen fertilizer. Further possible ingredients for fertilizers are described, for example, in Ullmann's Encyclopedia of Industrial Chemistry, 5th edition, 1987, volume A 10, pages 363 to 401, DE-A 41 28 828, DE-A 19 05 834 and DE-A 196 31 764. The general composition of the fertilizers, which, in the context of the present invention, may take the form of straight and/or compound fertilizers, for example composed of nitrogen, potassium or phosphorus, may vary within a wide range. In general, a content of 1% to 30% by weight of nitrogen (preferably 5% to 20% by weight), of 1% to 20% by weight of potassium (preferably 3% to 15% by weight) and a content of 1% to 20% by weight of phosphorus (preferably 3% to 10% by weight) is advantageous. The microelement content is usually in the ppm range, preferably in the range from 1 to 1000 ppm.

[0418] In the context of the present invention, the fertilizer and one or more inventive compounds of the general formula (I) may be administered simultaneously. However, it is also possible first to apply the fertilizer and then one or more inventive compounds of the general formula (I), or first to apply one or more compounds of the general formula (I) and then the fertilizer. In the case of nonsynchronous application of one or more compounds of the general formula (I) and the fertilizer, the application in the context of the present invention is, however, effected in a functional relationship, especially within a period of generally 24 hours, preferably 18 hours, more preferably 12 hours, specifically 6 hours, more specifically 4 hours, even more specifically within 2 hours. In very particular embodiments of the present invention, one or more compounds of the formula (I) according to the invention and the fertilizer are applied within a time frame of less than 1 hour, preferably less than 30 minutes, more preferably less than 15 minutes.

[0419] Preference is given to the use of compounds of the general formula (I) on plants from the group of the useful plants, ornamentals, turfgrass types, commonly used trees which are used as ornamentals in the public and domestic sectors, and forestry trees. Forestry trees include trees for the production of timber, cellulose, paper and products made from parts of the trees. The term useful plants as used here refers to crop plants which are used as plants for obtaining foods, animal feeds, fuels or for industrial purposes.

[0420] The useful plants include, for example, the following types of plants: triticale, durum (hard wheat), turf, vines, cereals, for example wheat, barley, rye, oats, rice, maize and millet; beet, for example sugar beet and fodder beet; fruits, for example pome fruit, stone fruit and soft fruit, for example apples, pears, plums, peaches, almonds, cherries and berries, for example strawberries, raspberries, blackberries; legumes, for example beans, lentils, peas and soybeans; oil crops, for example oilseed rape, mustard, poppies, olives, sunflowers, coconuts, castor oil plants, cocoa beans and peanuts; cucurbits, for example pumpkin/squash, cucumbers and melons; fibre plants, for example cotton, flax, hemp and jute; citrus fruits, for example oranges, lemons, grapefruit and tangerines; vegetables, for example spinach, lettuce, asparagus, cabbage species, carrots, onions, tomatoes, potatoes and bell peppers; Lauraceae, for example avocado, Cinnamomum, camphor, or also plants such as tobacco, nuts, coffee, aubergine, sugar cane, tea, pepper, grapevines, hops, bananas, latex plants and ornamentals, for example flowers, shrubs, deciduous trees and coniferous trees. This enumeration does not represent any limitation.

[0421] The following plants are considered to be particularly suitable target crops for the application of the method according to the invention: oats, rye, triticale, durum, cotton, aubergine, turf, pome fruit, stone fruit, soft fruit, maize, wheat, barley, cucumber, tobacco, vines, rice, cereals, pears, pepper, beans, soybeans, oilseed rape, tomato, bell pepper, melons, cabbage, potatoes and apples.

[0422] Examples of trees which can be improved by the method according to the invention include: Abies sp., Eucalyptus sp., Picea sp., Pinus sp., Aesculus sp., Platanus sp., Tilia sp., Acer sp., Tsuga sp., Fraxinus sp., Sorbus sp., Betula sp., Crataegus sp., Ulmus sp., Quercus sp., Fagus sp., Salix sp., Populus sp.

[0423] Preferred trees which can be improved by the method according to the invention include: from the tree species Aesculus: A. hippocastanum, A. pariflora, A. carnea; from the tree species Platanus: P. aceriflora, P. occidentalis, P. racemosa; from the tree species Picea: P. abies; from the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P. albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P. jeffregi, P. baksiana, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus, E. camadentis, E. nitens, E. obliqua, E. regnans, E. pilularus.

[0424] Particularly preferred trees which can be improved by the method according to the invention include: from the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus and E. camadentis.

[0425] Particularly preferred trees which can be improved by the method according to the invention include: horse chestnut, Platanaceae, linden tree and maple tree.

[0426] The present invention can also be applied to any desired turfgrasses, including cool-season turfgrasses and warm-season turfgrasses. Examples of cool-season turfgrasses are bluegrasses (Poa spp.), such as Kentucky bluegrass (Poa pratensis L.), rough bluegrass (Poa trivialis L.), Canada bluegrass (Poa compressa L.), annual bluegrass (Poa annua L.), upland bluegrass (Poa glaucantha Gaudin), wood bluegrass (Poa nemoralis L.) and bulbous bluegrass (Poa bulbosa L.); bentgrasses (Agrostis spp.) such as creeping bentgrass (Agrostis palustris Huds.), colonial bentgrass (Agrostis tenuis Sibth.), velvet bentgrass (Agrostis canina L.), South German Mixed Bentgrass (Agrostis spp. including Agrostis tenius Sibth., Agrostis canina L., and Agrostis palustris Huds.), and redtop (Agrostis alba L.); fescues (Festuca spp.), such as red fescue (Festuca rubra L. spp. rubra), creeping fescue (Festuca rubra L.), chewings fescue (Festuca rubra commutata Gaud.), sheep fescue (Festuca ovina L.), hard fescue (Festuca longifolia Thuill.), hair fescue (Festucu capillata Lam.), tall fescue (Festuca arundinacea Schreb.) and meadow fescue (Festuca elanor L.);

[0427] ryegrasses (Lolium spp.), such as annual ryegrass (Lolium multiflorum Lam.), perennial ryegrass (Lolium perenne L.) and Italian ryegrass (Lolium multiflorum Lam.);

[0428] and wheatgrasses (Agropyron spp.), such as fairway wheatgrass (Agropyron cristatum (L.) Gaertn.), crested wheatgrass (Agropyron desertorum (Fisch.) Schult.) and western wheatgrass (Agropyron smithii Rydb.).

[0429] Examples of further cool-season turfgrasses are beachgrass (Ammophila breviligulata Fern.), smooth bromegrass (Bromus inermis Leyss.), cattails such as Timothy (Phleum pratense L.), sand cattail (Phleum subulatum L.), orchardgrass (Dactylis glomerata L.), weeping alkaligrass (Puccinellia distans (L.) Parl.) and crested dog's-tail (Cynosurus cristatus L.).

[0430] Examples of warm-season turfgrasses are Bermuda grass (Cynodon spp. L. C. Rich), zoysia grass (Zoysia spp. Willd.), St. Augustine grass (iStenotaphrum secundatum Walt Kuntze), centipede grass (Eremochloa ophiuroides Munro Hack.), carpet grass (Axonopus affinis Chase), Bahia grass (Paspalum notatum Flugge), Kikuyu grass (Pennisetum clandestinum Hochst. ex Chiov.), buffalo grass (Buchloe dactyloids (Nutt.) Engelm.), Blue grama (Bouteloua gracilis (H.B.K.) Lag. ex Griffiths), seashore paspalum (Paspalum vaginatum Swartz) and sideoats grama (Bouteloua curtipendula (Michx. Torr.)). Cool-season turfgrasses are generally preferred for the use according to the invention. Particular preference is given to bluegrass, bentgrass and redtop, fescues and ryegrasses. Bentgrass is especially preferred.

[0431] Particular preference is given to using the inventive compounds of the general formula (I) to treat plants of the respective commercially available or commonly used plant cultivars. Plant cultivars are understood to mean plants which have new properties (traits) and which have been bred by conventional breeding, by mutagenesis or with the aid of recombinant DNA techniques. Crop plants may accordingly be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which are protectable or non-protectable by plant breeders' rights.

[0432] The treatment method according to the invention can thus also be used for the treatment of genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants in which a heterologous gene has been stably integrated into the genome. The expression heterologous gene essentially means a gene which is provided or assembled outside the plant and when introduced into the nuclear, chloroplastic or hypochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing (an)other gene(s) which is/are present in the plant (using for example antisense technology, cosuppression technology or RNAi technology [RNA interference]). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its specific presence in the plant genome is called a transformation or transgenic event.

[0433] Plants and plant varieties which are preferably treated with the compounds of the general formula (I) according to the invention include all plants which have genetic material which imparts particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means or not).

[0434] Plants and plant varieties which can likewise be treated with the compounds of the general formula (I) according to the invention are those plants which are resistant to one or more abiotic stress factors. Abiotic stress conditions may include, for example, heat, drought, cold and aridity stress, osmotic stress, waterlogging, increased soil salinity, increased exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients or shade avoidance.

[0435] Plants and plant cultivars which can likewise be treated with the compounds of the general formula (I) according to the invention are those plants which are characterized by enhanced yield characteristics. Enhanced yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can also be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to early flowering, flowering control for hybrid seed production, seedling vigour, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and oil composition, nutritional value, reduction in antinutritional compounds, improved processability and better storage stability.

[0436] Plants that may also be treated with the compounds of the general formula (I) according to the invention are hybrid plants that already express the characteristics of heterosis, or hybrid effect, which results in generally higher yield, higher vigour, better health and better resistance towards biotic and abiotic stress factors. Such plants are typically produced by crossing an inbred male-sterile parent line (the female crossbreeding parent) with another inbred male-fertile parent line (the male crossbreeding parent). Hybrid seed is typically harvested from the male-sterile plants and sold to growers. Male-sterile plants can sometimes (for example in maize) be produced by detasseling (i.e. mechanical removal of the male reproductive organs or male flowers); however, it is more typical for male sterility to be the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants, it is typically beneficial to ensure that male fertility in hybrid plants, which contain the genetic determinants responsible for male sterility, is fully restored. This can be accomplished by ensuring that the male crossbreeding parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described for Brassica species (WO 92/005251, WO 95/009910, WO 98/27806, WO2005/002324, WO2006/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male-sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/002069).

[0437] Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the compounds of the general formula (I) according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.

[0438] Herbicide-tolerant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Thus, for example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), the genes encoding a petunia EPSPS (Shah et al., Science (1986), 233, 478-481), a tomato EPSPS (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289) or an Eleusine EPSPS (WO2001/66704). It can also be a mutated EPSPS, as described, for example, in EP-A 0837944, WO 00/066746, WO2000/066747 or WO2002/026995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxidoreductase enzyme as described in U.S. Pat. No. 5,776,760 and U.S. Pat. No. 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described, for example, in WO2002/036782, WO2003/092360, WO2005/012515 and WO2007/024782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally occurring mutations of the abovementioned genes, as described, for example, in WO2001/024615 or WO2003/013226.

[0439] Other herbicide-resistant plants are for example plants that have been made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition. One such effective detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are described, for example, in U.S. Pat. No. 5,561,236; U.S. Pat. No. 5,648,477; U.S. Pat. No. 5,646,024; U.S. Pat. No. 5,273,894; U.S. Pat. No. 5,637,489; U.S. Pat. No. 5,276,268; U.S. Pat. No. 5,739,082; U.S. Pat. No. 5,908,810 and U.S. Pat. No. 7,112,665.

[0440] Further herbicide-tolerant plants are also plants that have been made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvate dioxygenase (HPPD). Hydroxyphenylpyruvate dioxygenases are enzymes that catalyse the reaction in which para-hydroxyphenylpyruvate (HPP) is converted to homogentisate. Plants tolerant to HPPD inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated HPPD enzyme according to WO 96/038567, WO 99/024585 and WO 99/024586. Tolerance to HPPD inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite inhibition of the native HPPD enzyme by the HPPD inhibitor. Such plants and genes are described in WO 99/034008 and WO 2002/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding a prephenate dehydrogenase enzyme in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928.

[0441] Other herbicide-resistant plants are plants which have been rendered tolerant to acetolactate synthase (ALS) inhibitors. Known ALS inhibitors include, for example, sulphonylurea, imidazolinone, triazolopyrimidines, pyrimidinyloxy(thio)benzoates, and/or sulphonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxy acid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described, for example, in Tranel and Wright, Weed Science (2002), 50, 700-712, and also in U.S. Pat. No. 5,605,011, U.S. Pat. No. 5,378,824, U.S. Pat. No. 5,141,870 and U.S. Pat. No. 5,013,659. The production of sulphonylurea-tolerant plants and imidazolinone-tolerant plants has been described in U.S. Pat. No. 5,605,011; U.S. Pat. No. 5,013,659; U.S. Pat. No. 5,141,870; U.S. Pat. No. 5,767,361; U.S. Pat. No. 5,731,180; U.S. Pat. No. 5,304,732; U.S. Pat. No. 4,761,373; U.S. Pat. No. 5,331,107; U.S. Pat. No. 5,928,937; and U.S. Pat. No. 5,378,824; and also in the international publication WO 96/033270. Further imidazolinone-tolerant plants have also been described, for example, in WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351 and WO 2006/060634. Further sulphonylurea- and imidazolinone-tolerant plants have also been described, for example, in WO 2007/024782.

[0442] Further plants tolerant to ALS-inhibitors, in particular to imidazolinones, sulphonylureas and/or sulphamoylcarbonyltriazolinones can be obtained by induced mutagenesis, by selection in cell cultures in the presence of the herbicide or by mutation breeding, as described, for example, for soybeans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugarbeet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599 or for sunflower in WO 2001/065922.

[0443] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the compounds of the general formula (I) according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.

[0444] In the present context, the term insect-resistant transgenic plant includes any plant containing at least one transgene comprising a coding sequence encoding:

[0445] 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins compiled by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, updated by Crickmore et al. (2005) in the Bacillus thuringiensis toxin nomenclature, (online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, for example proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae or Cry3Bb or insecticidal portions thereof; or

[0446] 2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cy34 and Cy35 crystal proteins (Moellenbeck et al., Nat. Biotechnol. (2001), 19, 668-72; Schnepf et al., Applied Environm. Microb. (2006), 71, 1765-1774); or

[0447] 3) a hybrid insecticidal protein comprising parts of two different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, for example the Cry1A.105 protein produced by maize event MON98034 (WO 2007/027777); or

[0448] 4) a protein of any one of points 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes induced in the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in maize events MON863 or MON88017, or the Cry3A protein in maize event MIR 604; or

[0449] 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal proteins (VIPs) listed under the following link, for example proteins from the VIP3Aa protein class: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html; or

[0450] 6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or

[0451] 7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or

[0452] 8) a protein of any one of points 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes induced in the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT 102.

[0453] Of course, the insect-resistant transgenic plants, as used herein, also include any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 8. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 8, to expand the range of the target insect species affected or to delay insect resistance development to the plants, by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.

[0454] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the compounds according to the invention of the general formula (I) are tolerant to abiotic stress factors. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerant plants include:

[0455] a. plants which contain a transgene capable of reducing the expression and/or the activity of the poly(ADP-ribose)polymerase (PARP) gene in the plant cells or plants, as described in WO 2000/004173 or EP 04077984.5 or EP 06009836.5;

[0456] b. plants which contain a stress tolerance-enhancing transgene capable of reducing the expression and/or the activity of the PARG-encoding genes of the plants or plant cells, as described, for example, in WO 2004/090140;

[0457] c. plants which contain a stress tolerance-enhancing transgene encoding a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage biosynthesis pathway, including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide adenine dinucleotide synthetase or nicotinamide phosphoribosyltransferase, as described, for example, in EP 04077624.7 or WO 2006/133827 or PCT/EP07/002433.

[0458] Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the compounds of the general formula (I) according to the invention show altered quantity, quality and/or storage stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as, for example:

[0459] 1) Transgenic plants which synthesize a modified starch which, in its physicochemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behaviour, the gelling strength, the starch granule size and/or the starch granule morphology, is changed in comparison with the synthesized starch in wild-type plant cells or plants, so that this modified starch is better suited to specific applications. These transgenic plants synthesizing a modified starch are described, for example, in EP 0571427, WO 95/004826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO 99/58690, WO 99/58654, WO 2000/008184, WO 2000/008185, WO 2000/28052, WO 2000/77229, WO 2001/12782, WO 2001/12826, WO 2002/101059, WO 2003/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 2000/22140, WO 2006/063862, WO 2006/072603, WO 2002/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 2001/14569, WO 2002/79410, WO 2003/33540, WO 2004/078983, WO 2001/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341, WO 2000/11192, WO 98/22604, WO 98/32326, WO 2001/98509, WO 2001/98509, WO 2005/002359, U.S. Pat. No. 5,824,790, U.S. Pat. No. 6,013,861, WO 94/004693, WO 94/009144, WO 94/11520, WO 95/35026 and WO 97/20936.

[0460] 2) Transgenic plants which synthesize non-starch carbohydrate polymers or which synthesize non-starch carbohydrate polymers with altered properties in comparison to wild-type plants without genetic modification. Examples are plants producing polyfructose, especially of the inulin and levan type, as described in EP 0663956, WO 96/001904, WO 96/021023, WO 98/039460 and WO 99/024593, plants producing alpha-1,4-glucans, as described in WO 95/031553, US 2002/031826, U.S. Pat. No. 6,284,479, U.S. Pat. No. 5,712,107, WO 97/047806, WO 97/047807, WO 97/047808 and WO 2000/14249, plants producing alpha-1,6-branched alpha-1,4-glucans, as described in WO 2000/73422, and plants producing alternan, as described in WO 2000/047727, EP 06077301.7, U.S. Pat. No. 5,908,975 and EP 0728213.

[0461] 3) Transgenic plants which produce hyaluronan, as for example described in WO 06/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006/304779 and WO 2005/012529.

[0462] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the compounds of the general formula (I) according to the invention are plants, such as cotton plants, with altered fibre characteristics. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such altered fibre characteristics and include:

[0463] a) plants, such as cotton plants, which contain an altered form of cellulose synthase genes, as described in WO 98/000549;

[0464] b) plants, such as cotton plants, which contain an altered form of rsw2 or rsw3 homologous nucleic acids, as described in WO 2004/053219;

[0465] c) plants, such as cotton plants, with an increased expression of sucrose phosphate synthase, as described in WO 2001/017333;

[0466] d) plants, such as cotton plants, with increased expression of sucrose synthase as described in WO 2002/45485;

[0467] e) plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fibre cell is altered, for example through downregulation of fibre-selective -1,3-glucanase as described in WO 2005/017157;

[0468] f) plants, such as cotton plants, which have fibres with altered reactivity, for example through expression of the N-acetylglucosamine transferase gene including nodC and chitin synthase genes, as described in WO 2006/136351.

[0469] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated with the compounds of the general formula (I) according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such altered oil characteristics and include:

[0470] a) plants, such as oilseed rape plants, which produce oil having a high oleic acid content, as described, for example, in U.S. Pat. No. 5,969,169, U.S. Pat. No. 5,840,946 or U.S. Pat. No. 6,323,392 or U.S. Pat. No. 6,063,947;

[0471] b) plants, such as oilseed rape plants, which produce oil having a low linolenic acid content, as described in U.S. Pat. No. 6,270,828, U.S. Pat. No. 6,169,190 or U.S. Pat. No. 5,965,755;

[0472] c) plants, such as oilseed rape plants, which produce oil having a low level of saturated fatty acids, as described, for example, in U.S. Pat. No. 5,434,283.

[0473] Particularly useful transgenic plants which may be treated with the compounds of the general formula (I) according to the invention are plants containing transformation events, or a combination of transformation events, and that are listed for example in the databases of various national or regional regulatory agencies.

[0474] Particularly useful transgenic plants which may be treated with the compounds of the general formula (I) according to the invention are, for example, plants which comprise one or more genes which encode one or more toxins and are the transgenic plants available under the following trade names: YIELD GARD (for example maize, cotton, soybeans), KnockOut (for example maize), BiteGard (for example maize), BT-Xtra (for example maize), StarLink (for example maize), Bollgard (cotton), Nucotn (cotton), Nucotn 33B (cotton), NatureGard (for example maize), Protecta and NewLeaf (potato). Examples of herbicide-tolerant plants which may be mentioned are maize varieties, cotton varieties and soya bean varieties which are available under the following trade names: Roundup Ready (tolerance to glyphosates, for example maize, cotton, soya), Liberty Link (tolerance to phosphinothricin, for example oilseed rape), IMI (tolerance to imidazolinone) and SCS (tolerance to sulphonylurea, for example maize). Herbicide-resistant plants (plants bred in a conventional manner for herbicide tolerance) which may be mentioned include the varieties sold under the name Clearfield (for example maize).

[0475] The compounds of the formula (I) to be used in accordance with the invention can be converted to customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, granules for broadcasting, suspoemulsion concentrates, natural compounds impregnated with active ingredient, synthetic substances impregnated with active ingredient, fertilizers, and also microencapsulations in polymeric substances. In the context of the present invention, it is especially preferred when the compounds of the general formula (I) are used in the form of a spray formulation.

[0476] The present invention therefore additionally also relates to a spray formulation for enhancing the resistance of plants to abiotic stress. A spray formulation is described in detail hereinafter:

[0477] The formulations for spray application are produced in a known manner, for example by mixing the compounds of the general formula (I) for use in accordance with the invention with extenders, i.e. liquid solvents and/or solid carriers, optionally with use of surfactants, i.e. emulsifiers and/or dispersants and/or foam formers. Further customary additives, for example customary extenders and solvents or diluents, dyes, wetting agents, dispersants, emulsifiers, antifoams, preservatives, secondary thickeners, stickers, gibberellins and also water, can optionally also be used. The formulations are produced either in suitable facilities or else before or during application.

[0478] Auxiliaries used may be those substances which are suitable for imparting particular properties to the composition itself or and/or to preparations derived therefrom (for example spray liquors), such as particular technical properties and/or else special biological properties. Typical auxiliaries include: extenders, solvents and carriers.

[0479] Suitable extenders are, for example, water, polar and nonpolar organic chemical liquids, for example from the classes of the aromatic and nonaromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which may optionally also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).

[0480] If the extender used is water, it is also possible to use, for example, organic solvents as auxiliary solvents. Useful liquid solvents essentially include: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example mineral oil fractions, mineral and vegetable oils, alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulphoxide, and also water.

[0481] It is possible to use dyes such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyes such as alizarin dyes, azo dyes and metal phthalocyanine dyes, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

[0482] Useful wetting agents which may be present in the formulations usable in accordance with the invention include all substances which promote wetting and which are conventionally used for the formulation of active agrochemical ingredients. Usable with preference are alkylnaphthalenesulphonates, such as diisopropyl- or diisobutylnaphthalenesulphonates.

[0483] Useful dispersants and/or emulsifiers which may be present in the formulations usable in accordance with the invention are all nonionic, anionic and cationic dispersants conventionally used for the formulation of active agrochemical ingredients. Preference is given to using nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants. Suitable nonionic dispersants include especially ethylene oxide/propylene oxide block polymers, alkylphenol polyglycol ethers and tristryrylphenol polyglycol ethers, and the phosphated or sulphated derivatives thereof. Suitable anionic dispersants are especially lignosulphonates, polyacrylic acid salts and arylsulphonate/formaldehyde condensates.

[0484] Antifoams which may be present in the formulations usable in accordance with the invention are all foam-inhibiting substances conventionally used for the formulation of active agrochemical ingredients. Preference is given to using silicone antifoams and magnesium stearate.

[0485] Preservatives which may be present in the formulations usable in accordance with the invention are all substances usable for such purposes in agrochemical compositions. Examples include dichlorophene and benzyl alcohol hemiformal.

[0486] Secondary thickeners which may be present in the formulations usable in accordance with the invention include all substances usable for such purposes in agrochemical compositions. Preferred examples include cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and finely divided silica.

[0487] Stickers which may be present in the formulations usable in accordance with the invention include all customary binders usable in seed-dressing products. Preferred examples include polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose. Gibberellins which may be present in the formulations usable in accordance with the invention are preferably the gibberellins A1, A3 (=gibberellic acid), A4 and A7; particular preference is given to using gibberellic acid. The gibberellins are known (cf. R. Wegler Chemie der Pflanzenschutz-und Schadlingsbekampfungsmittel [Chemistry of the Crop Protection Compositions and Pesticides], vol. 2, Springer Verlag, 1970, p. 401-412).

[0488] Further additives may be fragrances, mineral or vegetable, optionally modified oils, waxes and nutrients (including trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc. Additionally present may be stabilizers, such as cold stabilizers, antioxidants, light stabilizers or other agents which improve chemical and/or physical stability.

[0489] The formulations contain generally between 0.01% and 98% by weight, preferably between 0.5% and 90%, of the compound of the general formula (I).

[0490] The inventive compounds of the general formula (I) may be present in commercial formulations, and in the use forms prepared from these formulations, in a mixture with other active ingredients, such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth regulators, herbicides, safeners, fertilizers or semiochemicals.

[0491] In addition, the described positive effect of the compounds of the formula (I) on the plants' own defences can be supported by an additional treatment with active insecticidal, fungicidal or bactericidal compounds.

[0492] Preferred times for the application of compounds of the general formula (I) to be used according to the invention or salts thereof for enhancing resistance to abiotic stress are treatments of the soil, stems and/or leaves with the approved application rates.

[0493] The inventive active ingredients of the general formula (I) or salts thereof may generally additionally be present in their commercial formulations, and in the use forms prepared from these formulations, in mixtures with other active ingredients, such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, bactericides, growth regulators, substances which influence plant maturity, safeners or herbicides.

[0494] The invention is to be illustrated by the biological and biochemical examples which follow, but without restricting it thereto.

Biological Examples

In Vivo AnalysesPart A:

[0495] Seeds of monocotyledonous and dicotyledonous crop plants were sown in sandy loam in wood-fibre pots, covered with soil or sand and cultivated in a greenhouse under good growth conditions. The test plants were treated at the early leaf stage (BBCH10-BBCH13). To assure uniform water supply before commencement of stress, the potted plants were supplied with water by dam irrigation prior to substance application.

[0496] The inventive compounds, formulated in the form of wettable powders (WP), were sprayed onto the green parts of the plants as an aqueous suspension at an equivalent water application rate of 600 I/ha with addition of 0.2% wetting agent (e.g. agrotin). Substance application was followed immediately by stress treatment of the plants. For this purpose, the pots were transferred in plastic inserts in order to prevent them from subsequently drying out too quickly.

[0497] Drought stress was induced by gradual drying out under the following conditions:

[0498] Day: 14 hours with illumination at 26 C.

[0499] Night: 10 hours without illumination at 18 C.

[0500] The duration of the respective stress phases was guided mainly by the condition of the stressed control plants. It was ended (by re-irrigating and transfer to a greenhouse with good growth conditions) as soon as irreversible damage was observed on the stressed control plants.

[0501] The end of the stress phase was followed by an about 4-7-day recovery phase, during which the plants were once again kept under good growth conditions in a greenhouse.

[0502] The duration of the recovery phase was guided mainly by when the trial plants had attained a state which enabled visual scoring of potential effects, and was therefore variable.

[0503] Once this juncture was reached, the intensities of damage were scored visually in comparison to untreated, unstressed controls of the same age. The damage intensity was at first assessed in percent. These values were then used to calculate the efficacy of the test compounds by the following formula:

[00001]$\mathrm{EF}=\frac{\left({\mathrm{DI}}_s-{\mathrm{DI}}_t\right)100}{{\mathrm{DI}}_s}$ [0504] EF: Efficacy=reduction in damage intensity as a result of treatment with test substance [0505] DI.sub.s: Damage intensity of the stressed control plants [0506] DI.sub.t: Damage intensity of the plants treated with test compound

[0507] In order to rule out any influence on the effects observed by any fungicidal or insecticidal action of the test compounds, it was additionally ensured that the tests proceeded without fungal infection or insect infestation. The values reported in Tables A-1 to A-3 below are averages from at least one trial with at least two repeats.

[0508] Effects of Selected Compounds of the General Formula (I) Under Drought Stress:

TABLE-US-00010 TABLE A-1 EF [%] No. Substance Dosage Unit (BRSNS) 1 I.1-124 250 g/ha >5 2 I.1-136 250 g/ha >5 3 I.1-236 250 g/ha >5

TABLE-US-00011 TABLE A-2 EF [%] No. Substance Dosage Unit (ZEAMX) 1 I.1-136 250 g/ha >5 2 I.1-236 25 g/ha >5

TABLE-US-00012 TABLE A-3 EF [%] No. Substance Dosage Unit (TRZAS) 1 I.1-124 25 g/ha >5 2 I.1-136 25 g/ha >5 3 I.1-236 25 g/ha >5

[0509] In Vivo AnalysesPart B:

[0510] Seeds of monocotyledonous and dicotyledonous crop plants were sown in sandy loam in plastic pots, covered with soil or sand and cultivated in a greenhouse under good growth conditions. The test plants were treated at the early leaf stage (BBCH10-BBCH13). To assure uniform water supply before commencement of stress, the potted plants were supplied with water by dam irrigation prior to substance application.

[0511] The inventive compounds, formulated in the form of wettable powders (WP), were sprayed onto the green parts of the plants as an aqueous suspension at an equivalent water application rate of 600 I/ha with addition of 0.2% wetting agent (e.g. agrotin). Substance application was followed immediately by stress treatment of the plants.

[0512] Drought stress was induced by gradual drying out under the following conditions:

[0513] Day: 14 hours with illumination at 26-30 C.

[0514] Night: 10 hours without illumination at 18-20 C.

[0515] The duration of the respective stress phases was guided mainly by the condition of the stressed control plants. It was ended (by re-irrigating and transfer to a greenhouse with good growth conditions) as soon as irreversible damage was observed on the stressed control plants.

[0516] The end of the stress phase was followed by an about 4-7-day recovery phase, during which the plants were once again kept under good growth conditions in a greenhouse.

[0517] The duration of the recovery phase was guided mainly by when the trial plants had attained a state which enabled visual scoring of potential effects, and was therefore variable.

[0518] Once this juncture had been reached, the appearance of the plants treated with test substances was recorded in comparison to the stressed control plants by the following categories:

TABLE-US-00013 0 no positive effect 10 slight positive effect 20 clear positive effect 30 strong positive effect

[0519] In order to rule out any influence on the effects observed by any fungicidal or insecticidal action of the test compounds, it was additionally ensured that the tests proceeded without fungal infection or insect infestation. For each substance and dosage, 2-3 pots were treated and evaluated. The respective efficacy ranges are reported in Tables B-1 to B-3 below.

TABLE-US-00014 TABLE B-1 Effect No. Substance Dosage Unit (BRSNS) 1 I.1-102 250 g/ha 30 2 I.1-103 250 g/ha 30 3 I.1-120 250 g/ha 20 4 I.1-135 250 g/ha 30 5 I.1-202 250 g/ha 20 6 I.1-502 250 g/ha 20-30 7 I.1-503 25 g/ha 20-30 8 I.1-605 250 g/ha 20 9 I.1-606 250 g/ha 20 10 I.1-609 250 g/ha 10-20 11 I.1-614 250 g/ha 10-20 12 I.2-120 250 g/ha 30

TABLE-US-00015 TABLE B-2 Effect No. Substance Dosage Unit (ZEAMX) 1 I.1-103 25 g/ha 10-20 2 I.1-202 25 g/ha 10-20 3 I.1-609 25 g/ha 20

TABLE-US-00016 TABLE B-3 Effect No. Substance Dosage Unit (TRZAS) 1 I.1-103 250 g/ha 10-20 2 I.1-135 250 g/ha 30 3 I.1-202 250 g/ha 20 4 I.1-605 250 g/ha 20 5 I.1-609 250 g/ha 10

[0520] In Vivo AnalysesPart C:

[0521] Seeds of monocotyledonous and dicotyledonous crop plants were sown in sandy loam in plastic or wood-fibre pots, covered with soil or sand and cultivated in a greenhouse under good growth conditions. The test plants were treated at the early leaf stage (BBCH10-BBCH13). To assure uniform water supply before commencement of stress, the potted plants were supplied with water by dam irrigation prior to substance application.

[0522] The inventive compounds were first formulated as wettable powders (WP) or dissolved in a solvent mixture. The further dilution was effected with water supplemented with 0.2% wetting agent (e.g. agrotin). The finished spray liquor was sprayed onto the green parts of the plant at an equivalent water application rate of 600 I/ha. Substance application was followed immediately by stress treatment of the plants. For this purpose, the wood-fibre pots were transferred in plastic inserts in order to prevent them from subsequently drying out too quickly.

[0523] Drought stress was induced by gradual drying out under the following conditions:

[0524] Day: 14 hours with illumination at 26-30 C.

[0525] Night: 10 hours without illumination at 18-20 C.

[0526] The duration of the respective stress phases was guided mainly by the condition of the stressed control plants. It was ended (by re-irrigating and transfer to a greenhouse with good growth conditions) as soon as irreversible damage was observed on the stressed control plants.

[0527] The end of the stress phase was followed by an about 4-7-day recovery phase, during which the plants were once again kept under good growth conditions in a greenhouse.

[0528] The duration of the recovery phase was guided mainly by when the trial plants had attained a state which enabled visual scoring of potential effects, and was therefore variable.

[0529] Once this juncture had been reached, the appearance of the plants treated with test substances was recorded in comparison to the stressed control plants by the following categories:

TABLE-US-00017 0 no positive effect 10 slight positive effect 20 clear positive effect 30 strong positive effect

[0530] For each substance and dosage, 3-4 pots were treated and evaluated. The respective efficacy ranges are reported in Tables C-1 and C-2 below.

TABLE-US-00018 TABLE C-1 Effect No. Substance Dosage Unit (BRSNS) 1 I.1-618 25 g/ha 30 2 I.1-648 25 g/ha 30 3 I.1-678 250 g/ha 10-30 4 I.1-812 250 g/ha 10-20 5 I.1-887 250 g/ha 10-20 6 I.2-102 250 g/ha 10-20 7 I.2-201 250 g/ha 10-30 8 I.2-507 250 g/ha 30 9 I.2-543 25 g/ha 30 10 I.2-583 250 g/ha 10-30 11 I.2-615 250 g/ha 30 12 I.2-616 250 g/ha 20-30 13 I.3-128 250 g/ha 10-30

TABLE-US-00019 TABLE C-2 Effect No. Substance Dosage Unit (TRZAS) 1 I.1-157 25 g/ha 10 2 I.1-648 250 g/ha 10-20 3 I.1-662 25 g/ha 10-20 4 I.1-702 250 g/ha 10 5 I.1-732 25 g/ha 10 6 I.1-738 25 g/ha 10 7 I.1-752 25 g/ha 10 8 I.1-753 25 g/ha 10 9 I.1-762 250 g/ha 10 10 I.2-103 250 g/ha 30 11 I.2-201 25 g/ha 10 12 I.2-586 25 g/ha 10 13 I.2-591 25 g/ha 10 14 I.4-23 250 g/ha 10-20

[0531] In the Above Tables:

[0532] BRSNS=Brassica napus

[0533] TRZAS=Triticum aestivum

[0534] ZEAMX=Zea mays

[0535] In Vitro Analyses:

[0536] Effects of the phytohormone abscisic acid (ABA) on the behaviour of plants under abiotic stress and the mechanism of action of ABA are described in the literature (cf. Abrams et al, WO97/23441, Cutler, Park et al. Science, 2009, 324, 1068; Grill et al. Science, 2009, 324, 1064; Tanokura et al. Biophysics, 2011, 7, 123; Schroeder et al. Plant J. 2010, 61, 290). Therefore, it is possible with the aid of a suitable in vitro test system to derive a correlation between the action of ABA and the stress response of a plant under abiotic stress. Under drought stress, plants form the phytohormone abscisic acid (ABA). This binds, along with a co-regulator (Regulatory Component of ABA-Receptor=RCAR according to Grill et al. Science, 2009, 324, 1064 or PYR/PYL according to Cutler et al. Science, 2009, 324, 1068), to a phosphatase (e.g. ABI1, a type 2C protein phosphatase, also abbreviated to PP2C) and inhibits its activity. As a result, a downstream kinase (e.g. SnRK2) is no longer dephosphorylated. This kinase, which is thus active, via phosphorylation of transcription factors (e.g. AREB/ABF, vgl. Yoshida et al., Plant J. 2010, 61, 672), switches on a genetic protection programme to increase drought stress tolerance.

[0537] The assay described hereinafter utilizes the inhibition of the phosphatase ABI1 via the co-regulator RCAR11/PYR1 aus Arabidopsis thaliana.

[0538] For the determination of activity, the dephosphorylation of 4-methylumbelliferyl phosphate (MUP) was measured at 460 nm. The in vitro assay was conducted in Greiner 384-well PS microplates F-well, using two controls: a) dimethyl sulphoxide (DMSO) 0.5% (f.c.) and b) 5 M (f.c.) abscisic acid (ABA). The assay described here was generally conducted with substance concentrations of the appropriate chemical test substances in a concentration range of 0.1 M to 100 M in a solution of DMSO and water. The substance solution thus obtained, if necessary, was stirred with esterase from porcine liver (EC 3.1.1.1) at room temperature for 3 h and centrifuged at 4000 rpm for 30 min. A total volume of 45 l was introduced into each cavity of the microplate, having the following composition: [0539] 1) 5 l of substance solution, i.e. a) DMSO 5% or b) abscisic acid solution or c) the corresponding example compound of the general formula (I) dissolved in 5% DMSO. [0540] 2) 20 l of enzyme buffer mix, composed of a) 40% by vol. of enzyme buffer (10 ml contain equal proportions by volume of 500 mM Tris-HCl pH8, 500 mM NaCl, 3.33 mM MnCl.sub.2, 40 mM dithiothreitol (DTT)), b) 4% by vol. of ABI1 dilution (protein stock solution was diluted so as to give, after addition, a final concentration in the assay of 0.15 g ABI1/well), c) 4% by vol. of RCAR11 dilution (enzyme stock was diluted so as to give, on addition of the dilution to the enzyme buffer mix, a final concentration in the assay of 0.30 g enzyme/well), d) 5% by vol. of Tween20 (1%), e) 47% by vol. H.sub.2O bi-dist. [0541] 3) 20 l of substrate mix, composed of a) 10% by vol. of 500 mM Tris-HCl pH8, b) 10% by vol. of 500 mM NaCl, c) 10% by vol. of 3.33 mM MnCl.sub.2, d) 5% by vol. of 25 mM MUP, 5% by vol. of Tween20 (1%), 60% by vol. of H.sub.2O bi-dist.

[0542] Enzyme buffer mix and substrate mix were made up 5 minutes prior to the addition and warmed to a temperature of 35 C. On completion of pipetting of all the solutions and on completion of mixing, the plate was incubated at 35 C. for 20 minutes. Finally, a relative fluorescence measurement was made at 35 C. with a BMG Labtech POLARstar Optima microplate reader using a 340/10 nm excitation filter and a 460 nm emission filter. The efficacy of the compounds of the general formula (I) is reported in the table which follows using abscisic acid (No. 64) as comparative substance according to the following classification: ++++ (inhibition90%), +++ (90%>inhibition70%), ++ (70%>inhibition50%), +(50%>inhibition30%).

[0543] Effects of selected compounds of the general formula (I) in the above-described in vitro assay at a concentration of 5 mM of the substance of the general formula (I) in question in a solution of DMSO and water:

TABLE-US-00020 TABLE B-1 No. Substance ABI1 inhibition 1 I.1-36 +++ 2 I.1-102 ++++ 3 I.1-103 ++++ 4 I.1-120 +++ 5 I.1-124 ++++ 6 I.1-135 ++++ 7 I.1-136 +++ 8 I.1-202 ++++ 9 I.1-203 ++++ 10 I.1-220 ++++ 11 I.1.236 ++++ 12 I.1-502 ++++ 13 I.1-503 ++++ 14 I.1-520 ++++ 15 I.1-557 ++ 16 I.1-558 ++ 17 I.1-605 ++++ 18 I.1-606 ++++ 19 I.1-608 +++ 20 I.1-609 ++++ 21 I.1-610 ++++ 22 I.1-613 ++++ 23 I.1-614 ++++ 24 I.1-616 ++++ 25 I.1-618 ++++ 26 I.1-632 ++++ 27 I.1-648 ++++ 28 I.1-662 ++++ 29 I.1-678 ++++ 30 I.1-692 +++ 31 I.1-702 ++++ 32 I.1-723 +++ 33 I.1-732 ++++ 34 I.1-768 ++++ 35 I.1-773 +++ 36 I.1-782 +++ 37 I.1-783 +++ 38 I.1-792 +++ 39 I.1-798 ++++ 40 I.1-801 ++++ 41 I.1-812 +++ 42 I.1-813 +++ 43 I.1-822 +++ 44 I.1-887 +++ 45 I.1-888 +++ 46 I.2-102 ++++ 47 I.2-120 ++++ 48 I.2-130 +++ 49 I.2-134 ++++ 50 I.2-201 ++++ 51 I.2-507 ++++ 52 I.2-579 ++++ 53 I.2-581 ++++ 54 I.2-582 ++++ 55 I.2-583 ++++ 56 I.2-585 ++++ 57 I.2-586 ++++ 58 I.2-591 ++++ 59 I.2-593 +++ 60 I.2-615 ++++ 61 I.2-616 ++++ 62 I.2-617 +++ 63 I.3-128 ++ 64 abscisic acid ++++

[0544] Similar results were also achieved with further compounds of the general formula (I), even on application to different plant species.