Method for prevention and treatment of cancer, tuberculosis and related diseases

Abstract

A method for preventing and treating one or more disease states including the steps of altering the diet of an individual and then administering a drug to the individual. Plasma vitamin C level is reduced from a first level to a second level that is lower than the first level, such that a pharmacological response of the body of the individual to a drug at the first level is different from the pharmacological response of the body of said individual to the drug at the second level.

Claims

1. A method for the treatment of a pathogenic tumor in a patient, said method comprising the step of lowering the concentration of ascorbic acid or an oxidized or reduced derivative thereof in said pathogenic tumor for reducing the size thereof by administering a therapeutically effective amount of an agent that causes scurvy induced phagocytosis.

2. The method according to claim 1 further comprising the step of administering a therapeutically effective amount of a second agent that causes scurvy induced phagocytosis to the patient for lowering the concentration of ascorbic acid or an oxidized or reduced derivative thereof in said pathogenic tumor.

3. The method according to claim 1 further comprising the step of administering a therapeutically effective amount of a clathrate forming substance that is an anesthetic agent.

4. The method according to claim 3, wherein said clathrate forming substance comprises ether.

5. The method according to claim 1, wherein said pathogenic tumor is a cancerous lesion.

6. The method according to claim 1, wherein said pathogenic tumor is breast cancer.

Description

DETAILED DESCRIPTION

(1) Subclinical scurvy is generally defined as a condition wherein low levels of vitamin C are present in the blood stream but not to a point sufficient to present either the early symptoms of weakness and lassitude or the later symptoms of swelling of the legs and arms, softening of the gums, hemorrhages from the nose and gums and under the skin, and extensive degeneration of bone and cartilage. Individuals suffering from subclinical scurvy are generally termed scorbutic. In the present invention, a scorbutic patient will be defined a patient who, upon the contraction of an infectious disease and/or by the consumption of a vitamin C lowering substance, develops scurvy.

(2) Additionally, as is known in the art, scorbutic individuals are highly susceptible to infection. In scorbutic individuals having a marginal vitamin C intake, various infective agents, and certain chemical substances are known to be able to convert a case of subclinical scurvy, where the symptoms are relatively inconspicuous, into what is known as a fulminating scurvy. Fulminating means to happen with lighting speed. As used herein, a fulminating scurvy will be defined as a scurvy condition of the blood and/or various other tissues brought about by either an infection or a biological and/or chemical agent. For example, it is known in the art, that both diphtheria and erysipelas may bring about a fulminating scurvy. In addition, it is also known in the art, that the toxin in the pertussis vaccine can often throw a child into a fulminating scurvy to a point where hemorrhagic complications present themselves. In this case, the fulminating scurvy is brought about by consumption of vitamin C at enormous rates in the neutralization process of the pertussis toxin.

(3) There are a number of theories that can be developed as to why cancer, tuberculosis and other lipid raft-dependent diseases can be either prevented and/or treated by:

(4) 1. Reducing the level of vitamin C in either the blood stream or the tissues under consideration; and

(5) 2. By the use of clathrate substances during the treatment process.

(6) The inoculation of infective agents for lowering the plasma vitamin C level in the present invention is not limited to any of these theories that may be developed or are presented herein but is rather limited only by the claims presented. However, as an aid to those skilled in the art, I will state the following;

(7) A. I think that scurvy may operate in combating lipid-dependent diseases such as cancer, tuberculosis other new growth diseases, and the like by altering the orientation of one or more receptor proteins held within the lipid rafts in such a manner as to initiate scurvy-induced phagocytosis.

(8) B. I think that an infection that brings about a reduction in the level of vitamin C in either the tissues under consideration and/or blood level may also work by exciting the immune response involved in the scurvy-induced phagocytosis process.

(9) C. I think that clathrate-forming substances also combat lipid-dependent diseases by altering the orientation of one or more receptor proteins held within the lipid rafts.

(10) D. I think that humans have evolved to undergo scurvy as a means of combating certain chronic disease states such as tuberculosis and cancer and that the seasonal variation in the level of vitamin C at one time helped regulate the breeding cycle of humans. However, as just stated, these theories are not meant to define the scope and limitations of the present invention.

(11) In one embodiment of the present invention, the diet of the individual to be treated is first altered for lowering the plasma vitamin C level to alter the pharmacological response of the body to a drug such as, for example and in no way limiting the present invention to any particular drug, a clathrate-forming substance. In one form of the invention, the clathrate-forming substance is in the form of an anesthetic agent. In certain other embodiments, a substance, of a type well known in the art is given to the individual for quickly lowering the plasma vitamin C level of the individual and for preferably providing a fulminating scurvy condition.

(12) The plasma vitamin C level of the blood and/or other tissues is then measured to determine if the vitamin C content is low enough for bringing forth the symptoms of scurvy for altering the pharmacological response to the drug that is to be given. If so, the drug is then administered to the individual for preventing or treating one or more disease states. In other embodiments, one or more microbe for either preventing or treating one or more disease states is administered under scurvy conditions in place of or in addition to a drug for altering the therapeutic action of the microbe. In one from the present invention, the microbe is selected from the group comprising those that cause a skin and soft tissue infection such as erysipelas, erysipeloid and/or cellulitis.

(13) In the method of treatment of the present invention, the dietary intake of vitamin C for the patient is first reduced to a degree lower than normal for a sufficient time for altering the pharmacological response to a drug. A sufficient time may include, for example, a month.

(14) In addition to the vitamin C-restricted diet, it is preferred that one or more agents, hereinafter referred to as anti-vitamin C agents, for lowering the blood plasma level of vitamin C be administered to the patient for accelerating the reduction of vitamin C in the blood. The anti-vitamin C agent can be selected from the group comprising, a substance comprised of a metal or metalloid, an organic agent, an oxidizing agent, an infectious agent, or arsenic. For example, the substance comprised of metal may include, but is not limited to, copper, lead, silver, gold, and antimony.

(15) As is well known in the art, the level of vitamin C a particular patient has is highly dependent on a number of factors including the past consumption of vitamin C containing foods. In the preferred embodiment of the present invention, the patient would be given one or more anti-vitamin C agents in small doses that would be increased according to the individual patient's response. Of course, several blood samples will have to be drawn in order to come to the right dose but such things are expected in the art and cannot be otherwise calculated. In the preferred embodiment of the present invention, the level of both the anti-vitamin C agent and the plasma level of vitamin C is taken on a daily basis for determining the dosage regime necessary to create and maintain a fulminating scurvy condition.

(16) The organic agent may include, but is not limited to, bacterial toxins, such as for example, a diphtheria toxin that is injected. The oxidizing agent may be, but is not limited to, iodine that is given by mouth. The infectious agent may include, but is not limited to, a virus such as the common cold virus that would be injected into the patient.

(17) In one form of the present invention, before the a therapeutic agent is given, the level of plasma vitamin C is sustained at a sufficiently low level for the development of scurvy or to alter the cholesterol content of the lipid rafts. In certain embodiments, before the therapeutic agent is given, the plasma vitamin C level is held below normal levels until the early signs of scurvy are present, including, but not limited to, a feeling of general weakness, a leveling off of the HDL level of the blood, a scurvy-associated pathological change in one or more cell types in the body. Put differently, prior to the inoculation process, the level of vitamin C in the blood would be reduced to at least a subclinical scurvy level.

(18) If the anti-vitamin C agent comprises an organic compound that is a bacterium, the inoculation of the bacteria should be given directly over the site to be treated. For example, if the breast were to be treated, then the inoculation would be given on the skin at that site and if the brain is to be treated then the scalp should be inoculated. In addition, the nearby lymphatic vessels may also be inoculated. Of course the site should be sterilized before the inoculation process begins. It would be convenient to chose one or more strains of bacteria that are known to be highly responsive to known anti-bacterial drugs and/or antibiotics in case the infection should get out of hand. During the treatment, an iron-fortified diet should be provided in order to keep the bacteria growing and the vitamin C level should be monitored.

(19) The clathrate-forming substances and/or arsenic may also be used to lower the immune response in order for the bacteria to grow. In the case of the clathrate forming substances, these can be given three or four times a day in doses less than needed to bring about a complete anesthetic response. The arsenic should be given in amounts insufficient to cause death. The therapy should continue until the problem is resolved.

(20) The foregoing description of embodiments for this invention has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise form disclosed. Obvious modifications or variations are possible in light of the above teachings. The embodiments are chosen and described in an effort to provide illustrations of the principles of the invention and its practical application, and to thereby enable one of ordinary skill in the art to utilize the invention in various embodiments and with various modifications as are suited to the particular use contemplated. All such modifications and variations are within the scope of the invention as determined by the appended claims when interpreted in accordance with the breadth to which they are fairly, legally, and equitably entitled.