TARGETED DRUG DELIVERY DEVICE FOR ANTI-TUMOR MAGNETIC NANOPARTICLE DRUGS

Abstract

Provided is a targeted drug delivery device for antitumor magnetic nanoparticle drugs including a transfusion container for accommodating antitumor magnetic nanoparticle drugs and a drug solution conveying device connected to the transfusion container and used for conveying the antitumor magnetic nanoparticle drugs. A magnetic field generating device capable of producing magnetic adsorption to the antitumor magnetic nanoparticle drug and a bioelectric sensor for sensing the response of living tissues in a tumor region to magnetic stimulation are arranged at an external position of the human body corresponding to the tumor region. The targeted drug delivery device is provided with a control unit for receiving and analyzing signals of the bioelectric sensor and providing a master control on the required magnetic field intensity, transfusion speed and liquid flow according to the signals of the bioelectric sensor.

Claims

1-6. (canceled)

7. A targeted drug delivery device for antitumor magnetic nanoparticle drugs, comprising a transfusion container for accommodating antitumor magnetic nanoparticle drugs and a drug solution conveying device connected to the transfusion container and used for conveying the antitumor magnetic nanoparticle drugs, wherein a magnetic field generating device capable of producing magnetic adsorption to the antitumor magnetic nanoparticle drugs and a bioelectric sensor for sensing the response of living tissues in a tumor region to magnetic stimulation are arranged at an external position of the human body corresponding to the tumor region; a control unit is further provided for receiving and analyzing signals of the bioelectric sensor and providing a master control for a required magnetic field intensity, transfusion speed and liquid flow according to signals of the bioelectric sensor; a magnetic field control device for controlling the magnetic field intensity is connected to the magnetic field generating device; a flow rate controller is connected to the drug solution conveying device to control its flow rate; and the control unit is connected to the bioelectric sensor, the magnetic field control device and the flow rate controller respectively.

8. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 7, wherein the bioelectric sensor comprises a surface electrode or a needle electrode arranged on a surface of the treated region corresponding to the tumor region, a bioelectric amplifier and a signal processing system; and the surface electrode or the needle electrode is used to detect a bioelectric response of tissues in the treated region to the stimulation of the magnetic force and magnetic antitumor nano-drugs, and the bioelectric response will be conveyed to the control unit after a bioelectric amplification through the bioelectric amplifier and a signal analysis and processing through the signal processing system.

9. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 7, wherein the magnetic field generating device is in a form of alternating current coils which generating a rotating magnetic field, and is secured at an external position of the human body corresponding to the tumor region.

10. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 8, wherein the magnetic field generating device is in a form of alternating current coils which generating a rotating magnetic field, and is secured at an external position of the human body corresponding to the tumor region.

11. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 7, wherein the magnetic field generating device is in a form of a number of magnetic materials adhered at an external position corresponding to the tumor region by medical dressings or adhesive tapes.

12. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 11, wherein the magnetic materials are magnets.

13. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 12, wherein medical breathable materials are filled between the magnetic materials and the medical dressings or the adhesive tapes.

14. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 8, wherein the magnetic field generating device is in a form of a number of magnetic materials adhered at an external position corresponding to the tumor region, by medical dressings or adhesive tapes.

15. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 14, wherein the magnetic materials are magnets.

16. The targeted drug delivery device for antitumor magnetic nanoparticle drugs according to claim 15, wherein medical breathable materials are filled between the magnetic materials and the medical dressings or the adhesive tapes.

Description

BRIEF DESCRIPTION

[0017] Some of the embodiments will be described in detail, with reference to the following figures, wherein like designations denote like members, wherein:

[0018] FIG. 1 is a schematic diagram showing the binding process of magnetic nanoparticles and antitumor drugs;

[0019] FIG. 2 is a structural schematic diagram of the targeted drug delivery device for magnetic nanoparticle antitumor drugs of embodiments of the present invention;

[0020] FIG. 3 is a schematic diagram showing the structure and connection of the bioelectric sensor according to Example 1;

[0021] FIG. 4 is a structural schematic diagram of the magnetic field generating device according to Example 1;

[0022] FIG. 5 illustrates the therapy principle of the magnetic antitumor nano-drugs;

[0023] FIG. 6 is a structural schematic diagram of the magnetic field generating device according to Example 2.

DETAILED DESCRIPTION

EXAMPLE 1

[0024] As shown in FIG. 2, a targeted drug delivery device for antitumor magnetic nanoparticle drugs of embodiments of the present invention comprises a transfusion container 1 for accommodating antitumor magnetic nanoparticle drugs; and a drug solution conveying device 2 connected to the transfusion container 1 and used for conveying the antitumor magnetic nanoparticle drug. A magnetic field generating device 3 capable of producing magnetic adsorption to the antitumor magnetic nanoparticle drugs and a bioelectric sensor 4 for sensing the response of living tissues in a tumor region to magnetic stimulation are arranged at external positions of the human body corresponding to the tumor region. A control unit 5 is further provided for receiving and analyzing signals of the bioelectric sensor 4 and providing a master control on the required magnetic field intensity, transfusion speed and liquid flow according to the signals of the bioelectric sensor 4. A magnetic field control device 6 is connected to the magnetic field generating device 3 to control the magnetic field intensity. A flow rate controller 7 is connected to the drug solution conveying device 3 to control the flow rate of the drug solution. The control unit 5 is connected to the bioelectric sensor 4, the magnetic field control device 6 and the flow rate controller 7 respectively.

[0025] As shown in FIG. 3, the bioelectric sensor 4 comprises a surface electrode 41 or a needle electrode 42 arranged on the surface of the treated region corresponding to the tumor region, a bioelectric amplifier and a signal processing system 43. The bioelectric amplifier comprises a front amplifier 44, a high-pass filter 45, an isolation amplifier 46 and a low-pass filter 47 connected between each other. The bioelectric sensor 4 receives the bioelectric response of the tissues in the treated region to the stimulation of magnetic field force and magnetic antitumor nano-drugs, by the surface electrode 41 or needle electrode 42. The bioelectric response will be conveyed to the control unit 5 after a bioelectric amplification by the bioelectric amplifier and a signal analysis and processing by the signal processing system. The magnetic field intensity and the drug conveying speed are further adjusted by the control unit 5 according to the bioelectric signal strength and range in the treated region, and such control based on real-time feedback to the magnetic field control device 6 and control unit 5, according to the bioelectric signal of tissues in treated region in response to the stimulation of magnetic force and drugs, ensures a adjustment with a higher accuracy and improved safety performance.

[0026] As shown in FIG. 4, the magnetic generating device 3 is in a form of alternating current coils generating a rotating magnetic field, and it is secured at an external position of the body surface corresponding to the tumor region, by using the fasteners (no shown in figures). A magnetic control unit 6 is connected to the magnetic field generating device 3 to effectively control the intensity and rotating speed of the magnetic field. The magnetic control device 6 can adjust the magnetic field intensity of the magnetic field generating device 3 in real time, according to the distance between the tumor and the body surface, and the magnetic control device is conveniently used and well controlled. The magnetic field generating device 3 may be designed into corresponding shapes according to the shape of the treated region. For example, it may be jaw-shaped for the jaw tumor, cap-shaped for the brain tumor, and cannular for the tumors in thyroid gland of the neck, limbs, chest and abdomen.

[0027] The principle of the Example can be seen in FIG. 5, the magnetic nanoparticle antitumor drugs 30 flow from the blood vessels 40 into the tumor region 50, and they will be controlled in the tumor region 50 under the absorption of magnetic field generating device 3, whereas those cells 60 unlabelled by the magnetic nanoparticles in the tumor region 50 will continue to flow along the blood vessels 40.

EXAMPLE 2

[0028] This Example is similar with Example 1, however they differ in that the magnetic generating device 3 is a number of magnetic materials adhering to an external position of the human body corresponding to the tumor region, by medical dressings or adhesive tapes 8, as shown in FIG. 6. The magnetic materials are magnets, and the magnetic force of the magnetic device can be controlled by adjusting the amount of the magnets. In order to make the magnetic materials and the profile of the treated region fit closely, and to improve the air permeability and flexibility, medical breathable materials are filled between the magnetic materials or between the magnetic materials and adhesive tapes.

[0029] Although the present invention has been disclosed in the form of preferred embodiments and variations thereon, it will be understood that numerous additional modifications and variations could be made thereto without departing from the scope of the invention.

[0030] For the sake of clarity, it is to be understood that the use of a or an throughout this application does not exclude a plurality, and comprising does not exclude other steps or elements.