Apparatus and method for preparing hemostatic gauze

Abstract

Disclosed are an apparatus and a method for preparing hemostatic gauze with high stability and absorptivity. The apparatus includes a tank body, a tank cover matching the tank body, stainless steel plates within the tank body, an ultrasonic generator under the tank body, a feed pipe and a liquid outlet, where the tank cover is arranged with an air inlet and an air outlet, and the feed pipe, the air inlet, the air outlet and the liquid outlet are all equipped with a valve respectively.

Claims

1. An apparatus for preparing hemostatic gauze, wherein the apparatus comprises a tank body, a tank cover matching the tank body, stainless steel plates (6) within the tank body, an ultrasonic generator (10) under the tank body, a feed pipe (1) and a liquid outlet (7), wherein the tank cover is arranged with an air inlet (2) and an air outlet (3), and the feed pipe (1), the air inlet (2), the air outlet (3) and the liquid outlet (7) are all equipped with a valve (4) respectively.

2. The apparatus according to claim 1, wherein at least more than one layer of the stainless steel plate (6) is stacked up within the tank body, and the stainless steel plates (6) are parallel with intervals there-between.

3. The apparatus according to claim 2, wherein the stainless steel plates are arranged with through holes and hand holes (9), wherein the through holes are circular holes (8) evenly distributed on the stainless steel plates (6), and the hand holes (9) are semicircular holes located at the middle section of both sides of the stainless steel plates (6).

4. The apparatus according to claims 1, wherein the feed pipe (1) comprises a feeding part outside the tank body and an elbow pipe (5) within the tank body, wherein the feed inlet of the feed pipe (1) is located at the bottom of the side of the tank body, the feeding part is formed with a transparent material, and the elbow pipe (5) contacts the bottom of the tank body and has densely distributed air holes.

5. The apparatus according to claim 4, wherein the liquid outlet (7) is arranged at the bottom of a side of the tank body, opposite to a feed side of the tank body, and the liquid outlet (7) is at a distance of 1 cm or more from the bottom of the tank body.

6. The apparatus according to claim 4, wherein the ultrasonic generator (10) is arranged under the tank body with a layer of the stainless steel plate (6) between them.

7. The apparatus according to claim 2, wherein the feed pipe (1) comprises a feeding part outside the tank body and an elbow pipe (5) within the tank body, wherein the feed inlet of the feed pipe (1) is located at the bottom of the side of the tank body, the feeding part is formed with a transparent material, and the elbow pipe (5) contacts the bottom of the tank body and has densely distributed air holes.

8. The apparatus according to claim 3, wherein the feed pipe (1) comprises a feeding part outside the tank body and an elbow pipe (5) within the tank body, wherein the feed inlet of the feed pipe (1) is located at the bottom of the side of the tank body, the feeding part is formed with a transparent material, and the elbow pipe (5) contacts the bottom of the tank body and has densely distributed air holes.

9. A method for preparing hemostatic gauze using the apparatus according to claim 1, comprising the following steps: 1) placing cellulose fabrics on the stainless steel plates (6); 2) placing and stacking up the stainless steel plates (6) layer by layer within the tank body, putting on the tank cover, wherein a space between the tank cover and the tank body is sealed with a PTFE gasket and the sealing is tightened with a nut; 3) opening the valves (4) of the feed pipe (1) and the air outlet (3), connecting the air outlet (3) to a tail gas absorber, adding a dilute sodium hydroxide solution with the concentration of 0.5 to 5% to a specific position where all cellulose fabrics are completely immersed; 4) sonicating with the ultrasonic generator (10) for 0.5 to 2 hours to obtain an oxidized raw material of the cellulose fabrics; 5) after discharging the reaction solution through the liquid outlet (7), adding demin-water through the feed pipe (1) three times to a position where the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 6) emptying the wash water when it is neutral, and adding an anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 7) drying with N.sub.2 gas filled in through the feed pipe (1) and obtaining the preprocessed material of the cellulose fabrics after fully drying; 8) introducing anhydrous cyclohexane or methyl cyclohexane through the feed pipe (1), wherein water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicating for 10 minutes to empty the air in the reaction system, reserving for further use; 9) introducing NO.sub.2 gas into the reaction system, and making the concentration of the NO.sub.2 gas to be 0.2 to 2.1 mol/L in the oxidation reaction system; 10) sealing the reaction system, and the oxidation reaction of the cellulose fabrics starting at room temperature; 11) with the development of the reaction, constantly produced by-products accumulating on the materials of the cellulose fabrics; during the reaction, sonicating for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products; 12) after 2-to-48-hour reaction, closing the valves (4) of the feed pipe (1) and the air outlet (3), and opening the liquid outlet (7), and introducing N.sub.2 gas through the air inlet (2) to discharge the reaction solution into a storage tank through the liquid outlet (7); 13) opening the valves (4) of the feed pipe (1) and the air outlet (3), introducing cyclohexane or methyl cyclohexane for washing, and then discharging the liquid after sonicating for 5 minutes; 14) using an ethanol water solution with the mass percent of 50 to 95% for immersion and washing, and discharging the liquid after sonicating for 5 minutes; when the pH of the effluent after washing is equal to 5 to 7, using absolute ethyl alcohol for immersion and washing again, and discharging the liquid after sonicating for 5 minutes; 15) introducing dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose; and 16) obtaining the completely dried products, that is, the hemostatic gauze with high stability and absorptivity, and storing and packing the hemostatic gauze in N.sub.2 atmosphere.

10. The method according to claim 9, wherein fiber fineness of the cellulose fabrics is between 0.5 and 5 deniers and fabric weight is between 40 and 500 g/m.sup.2.

11. The method according to claim 9, wherein reaction time of the step 12) is 4 to 24 hours.

12. The method according to claim 9, wherein a warranty period of the hemostatic gauze is 2 years.

13. A method for preparing hemostatic gauze using the apparatus according to claim 2, comprising the following steps: 1) placing cellulose fabrics on the stainless steel plates (6); 2) placing and stacking up the stainless steel plates (6) layer by layer within the tank body, putting on the tank cover, wherein a space between the tank cover and the tank body is sealed with a PTFE gasket and the sealing is tightened with a nut; 3) opening the valves (4) of the feed pipe (1) and the air outlet (3), connecting the air outlet (3) to a tail gas absorber, adding a dilute sodium hydroxide solution with the concentration of 0.5 to 5% to a specific position where all cellulose fabrics are completely immersed; 4) sonicating with the ultrasonic generator (10) for 0.5 to 2 hours to obtain an oxidized raw material of the cellulose fabrics; 5) after discharging the reaction solution through the liquid outlet (7), adding demin-water through the feed pipe (1) three times to a position where the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 6) emptying the wash water when it is neutral, and adding an anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 7) drying with N.sub.2 gas filled in through the feed pipe (1) and obtaining the preprocessed material of the cellulose fabrics after fully drying; 8) introducing anhydrous cyclohexane or methyl cyclohexane through the feed pipe (1), wherein water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicating for 10 minutes to empty the air in the reaction system, reserving for further use; 9) introducing NO.sub.2 gas into the reaction system, and making the concentration of the NO.sub.2 gas to be 0.2 to 2.1 mol/L in the oxidation reaction system; 10) sealing the reaction system, and the oxidation reaction of the cellulose fabrics starting at room temperature; 11) with the development of the reaction, constantly produced by-products accumulating on the materials of the cellulose fabrics; during the reaction, sonicating for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products; 12) after 2-to-48-hour reaction, closing the valves (4) of the feed pipe (1) and the air outlet (3), and opening the liquid outlet (7), and introducing N.sub.2 gas through the air inlet (2) to discharge the reaction solution into a storage tank through the liquid outlet (7); 13) opening the valves (4) of the feed pipe (1) and the air outlet (3), introducing cyclohexane or methyl cyclohexane for washing, and then discharging the liquid after sonicating for 5 minutes; 14) using an ethanol water solution with the mass percent of 50 to 95% for immersion and washing, and discharging the liquid after sonicating for 5 minutes; when the pH of the effluent after washing is equal to 5 to 7, using absolute ethyl alcohol for immersion and washing again, and discharging the liquid after sonicating for 5 minutes; 15) introducing dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose; and 16) obtaining the completely dried products, that is, the hemostatic gauze with high stability and absorptivity, and storing and packing the hemostatic gauze in N.sub.2 atmosphere.

14. A method for preparing hemostatic gauze using the apparatus according to claim 3, comprising the following steps: 1) placing cellulose fabrics on the stainless steel plates (6); 2) placing and stacking up the stainless steel plates (6) layer by layer within the tank body, putting on the tank cover, wherein a space between the tank cover and the tank body is sealed with a PTFE gasket and the sealing is tightened with a nut; 3) opening the valves (4) of the feed pipe (1) and the air outlet (3), connecting the air outlet (3) to a tail gas absorber, adding a dilute sodium hydroxide solution with the concentration of 0.5 to 5% to a specific position where all cellulose fabrics are completely immersed; 4) sonicating with the ultrasonic generator (10) for 0.5 to 2 hours to obtain an oxidized raw material of the cellulose fabrics; 5) after discharging the reaction solution through the liquid outlet (7), adding demin-water through the feed pipe (1) three times to a position where the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 6) emptying the wash water when it is neutral, and adding an anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 7) drying with N.sub.2 gas filled in through the feed pipe (1) and obtaining the preprocessed material of the cellulose fabrics after fully drying; 8) introducing anhydrous cyclohexane or methyl cyclohexane through the feed pipe (1), wherein water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicating for 10 minutes to empty the air in the reaction system, reserving for further use; 9) introducing NO.sub.2 gas into the reaction system, and making the concentration of the NO.sub.2 gas to be 0.2 to 2.1 mol/L in the oxidation reaction system; 10) sealing the reaction system, and the oxidation reaction of the cellulose fabrics starting at room temperature; 11) with the development of the reaction, constantly produced by-products accumulating on the materials of the cellulose fabrics; during the reaction, sonicating for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products; 12) after 2-to-48-hour reaction, closing the valves (4) of the feed pipe (1) and the air outlet (3), and opening the liquid outlet (7), and introducing N.sub.2 gas through the air inlet (2) to discharge the reaction solution into a storage tank through the liquid outlet (7); 13) opening the valves (4) of the feed pipe (1) and the air outlet (3), introducing cyclohexane or methyl cyclohexane for washing, and then discharging the liquid after sonicating for 5 minutes; 14) using an ethanol water solution with the mass percent of 50 to 95% for immersion and washing, and discharging the liquid after sonicating for 5 minutes; when the pH of the effluent after washing is equal to 5 to 7, using absolute ethyl alcohol for immersion and washing again, and discharging the liquid after sonicating for 5 minutes; 15) introducing dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose; and 16) obtaining the completely dried products, that is, the hemostatic gauze with high stability and absorptivity, and storing and packing the hemostatic gauze in N.sub.2 atmosphere.

15. A method for preparing hemostatic gauze using the apparatus according to claim 5, comprising the following steps: 1) placing cellulose fabrics on the stainless steel plates (6); 2) placing and stacking up the stainless steel plates (6) layer by layer within the tank body, putting on the tank cover, wherein a space between the tank cover and the tank body is sealed with a PTFE gasket and the sealing is tightened with a nut; 3) opening the valves (4) of the feed pipe (1) and the air outlet (3), connecting the air outlet (3) to a tail gas absorber, adding a dilute sodium hydroxide solution with the concentration of 0.5 to 5% to a specific position where all cellulose fabrics are completely immersed; 4) sonicating with the ultrasonic generator (10) for 0.5 to 2 hours to obtain an oxidized raw material of the cellulose fabrics; 5) after discharging the reaction solution through the liquid outlet (7), adding demin-water through the feed pipe (1) three times to a position where the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 6) emptying the wash water when it is neutral, and adding an anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 7) drying with N.sub.2 gas filled in through the feed pipe (1) and obtaining the preprocessed material of the cellulose fabrics after fully drying; 8) introducing anhydrous cyclohexane or methyl cyclohexane through the feed pipe (1), wherein water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicating for 10 minutes to empty the air in the reaction system, reserving for further use; 9) introducing NO.sub.2 gas into the reaction system, and making the concentration of the NO.sub.2 gas to be 0.2 to 2.1 mol/L in the oxidation reaction system; 10) sealing the reaction system, and the oxidation reaction of the cellulose fabrics starting at room temperature; 11) with the development of the reaction, constantly produced by-products accumulating on the materials of the cellulose fabrics; during the reaction, sonicating for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products; 12) after 2-to-48-hour reaction, closing the valves (4) of the feed pipe (1) and the air outlet (3), and opening the liquid outlet (7), and introducing N.sub.2 gas through the air inlet (2) to discharge the reaction solution into a storage tank through the liquid outlet (7); 13) opening the valves (4) of the feed pipe (1) and the air outlet (3), introducing cyclohexane or methyl cyclohexane for washing, and then discharging the liquid after sonicating for 5 minutes; 14) using an ethanol water solution with the mass percent of 50 to 95% for immersion and washing, and discharging the liquid after sonicating for 5 minutes; when the pH of the effluent after washing is equal to 5 to 7, using absolute ethyl alcohol for immersion and washing again, and discharging the liquid after sonicating for 5 minutes; 15) introducing dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose; and 16) obtaining the completely dried products, that is, the hemostatic gauze with high stability and absorptivity, and storing and packing the hemostatic gauze in N.sub.2 atmosphere.

16. A method for preparing hemostatic gauze using the apparatus according to claim 6, comprising the following steps: 1) placing cellulose fabrics on the stainless steel plates (6); 2) placing and stacking up the stainless steel plates (6) layer by layer within the tank body, putting on the tank cover, wherein a space between the tank cover and the tank body is sealed with a PTFE gasket and the sealing is tightened with a nut; 3) opening the valves (4) of the feed pipe (1) and the air outlet (3), connecting the air outlet (3) to a tail gas absorber, adding a dilute sodium hydroxide solution with the concentration of 0.5 to 5% to a specific position where all cellulose fabrics are completely immersed; 4) sonicating with the ultrasonic generator (10) for 0.5 to 2 hours to obtain an oxidized raw material of the cellulose fabrics; 5) after discharging the reaction solution through the liquid outlet (7), adding demin-water through the feed pipe (1) three times to a position where the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 6) emptying the wash water when it is neutral, and adding an anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharging the liquid after sonicating for 10 minutes; 7) drying with N.sub.2 gas filled in through the feed pipe (1) and obtaining the preprocessed material of the cellulose fabrics after fully drying; 8) introducing anhydrous cyclohexane or methyl cyclohexane through the feed pipe (1), wherein water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicating for 10 minutes to empty the air in the reaction system, reserving for further use; 9) introducing NO.sub.2 gas into the reaction system, and making the concentration of the NO.sub.2 gas to be 0.2 to 2.1 mol/L in the oxidation reaction system; 10) sealing the reaction system, and the oxidation reaction of the cellulose fabrics starting at room temperature; 11) with the development of the reaction, constantly produced by-products accumulating on the materials of the cellulose fabrics; during the reaction, sonicating for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products; 12) after 2-to-48-hour reaction, closing the valves (4) of the feed pipe (1) and the air outlet (3), and opening the liquid outlet (7), and introducing N.sub.2 gas through the air inlet (2) to discharge the reaction solution into a storage tank through the liquid outlet (7); 13) opening the valves (4) of the feed pipe (1) and the air outlet (3), introducing cyclohexane or methyl cyclohexane for washing, and then discharging the liquid after sonicating for 5 minutes; 14) using an ethanol water solution with the mass percent of 50 to 95% for immersion and washing, and discharging the liquid after sonicating for 5 minutes; when the pH of the effluent after washing is equal to 5 to 7, using absolute ethyl alcohol for immersion and washing again, and discharging the liquid after sonicating for 5 minutes; 15) introducing dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose; and 16) obtaining the completely dried products, that is, the hemostatic gauze with high stability and absorptivity, and storing and packing the hemostatic gauze in N.sub.2 atmosphere.

Description

BRIEF DESCRIPTION OF DRAWINGS

[0048] FIG. 1 is a schematic diagram of the integral structure of the preparation apparatus of the invention.

[0049] FIG. 2 is a top view of the structure of the cover for the preparation apparatus of the invention.

[0050] FIG. 3 is a top view of the structure of the stainless steel plates.

[0051] Where 1 is the feed pipe, 2 is the air inlet, 3 is the air outlet, 4 are the valves, 5 is the elbow pipe, 6 are the stainless steel plates, 7 is the liquid outlet, 8 are the circular holes, 9 are the hand holes, 10 is the ultrasonic generator, 11 is the gasket and 12 is the nut.

DETAILED DESCRIPTION OF THE INVENTION

[0052] Referring to FIGS. 1-3, the present application discloses a apparatus for preparing hemostatic gauze with high stability and absorptivity, including a tank body, a tank cover matching the tank body, stainless steel plates 6 within the tank body, an ultrasonic generator 10 under the tank body, a feed pipe 1 and a liquid outlet 7, where the tank cover is arranged with an air inlet 2 and an air outlet 3, and the feed pipe 1, the air inlet 2, the air outlet 3 and the liquid outlet 7 are all equipped with a valve 4 respectively; at least more than one layer of the stainless steel plate 6 is stacked up within the tank body, and the stainless steel plates 6 are in parallel with intervals there-between each layer of steel plates, where multi-layer stainless steel plates 6 for placing cellulose fabrics can be stacked up within the tank body; the stainless steel plates are arranged with through holes and hand holes 9, where the through holes are circular holes 8 evenly distributed on the stainless steel plates 6, and the hand holes 9 are semicircular holes located at the middle section of both sides of the stainless steel plates 6, and the stainless steel plates 6 full of the circular holes 8 can ensure sufficient contact between the reaction solution and the cellulose fabrics; the feed pipe 1 includes a feeding part outside the tank body and an elbow pipe 5 within the tank body, where the feed inlet of the feed pipe 1 is located at the bottom of the side of the tank body, the feeding part is formed with a transparent material, and the elbow pipe 5 contacts the bottom of the tank body and has densely distributed air holes. A reaction solution enters the tank body firstly through the feed pipe 1, where the feed pipe 1 is formed with a transparent material and the liquid level within the tank body can be observed according to the theory of communicating vessels; a reactant gas fills into the tank body through the feed pipe 1, and flows out through the small holes of the elbow pipe 5 at the bottom of the tank body in the form of dispersed bubbles and dissolves in the reaction solution; and NO.sub.2 gas enters the tank body through the elbow pipe 5 with holes at the bottom of the tank body and can rapidly dissolve in the organic solvent, reducing the waste of the NO.sub.2 gas; the liquid outlet 7 is arranged at the bottom of a side of the tank body, opposite to a feed side of the tank body; after reaction, the reaction solution is discharged from the liquid outlet 7 and can be recycled; the impurities and effluent produced during the reaction will separate from the reaction solution, deposit at the bottom, and can be timely discharged through the liquid outlet 7; the ultrasonic generator 10 is arranged under the tank body with a layer of the stainless steel plate 6 between them; the ultrasonic generator 10 under the tank body can sonicate the liquid within the tank body and strengthen the mass transfer and the reaction.

[0053] The technical solutions of the invention will be further described in detail with reference to the embodiments below to illustrate the preparation method for hemostatic gauze.

Embodiment 1

[0054] The preparation apparatus of the invention for hemostatic gauze with high stability and absorptivity is adopted, where the fiber fineness of the raw material of the cellulose fabrics is 0.5 denier, and the fabric weight is 40 g/m.sup.2.

[0055] The process adopting the apparatus to prepare hemostatic gauze with high stability and absorptivity includes following steps:

[0056] Place the cellulose fabrics with a weight of 400 g on the stainless steel plates 6.

[0057] Place and stack up the stainless steel plates 6 layer by layer within the tank body, put on the tank cover, where the space between the tank cover and the tank body is sealed with the PTFE gasket 11 and the sealing is tightened with the nut 12.

[0058] Open the valves 4 of the feed pipe 1 and the air outlet 3, and connect the air outlet 3 to the tail gas absorber. Add the dilute sodium hydroxide solution with the concentration of 0.5% to a specific position where all cellulose fabrics are completely immersed.

[0059] Sonicate for 2 hours to obtain the oxidized raw material of the cellulose fabrics.

[0060] After discharging the reaction solution, add demin-water three times to a position where the cellulose fabrics are completely immersed, and then discharge the liquid after sonicating for 10 minutes.

[0061] Empty the wash water when it is neutral and add the anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharge the liquid after sonicating for 10 minutes.

[0062] Dry with N.sub.2 gas, and obtain the preprocessed material of the cellulose fabrics after fully drying.

[0063] Introduce the anhydrous cyclohexane through the feed pipe 1, where the water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicate for 10 minutes to empty the air in the reaction system. Reserve for further use.

[0064] Introduce NO.sub.2 gas into the reaction system, and make the concentration of the NO.sub.2 gas to be 0.2 mol/L in the oxidation reaction system.

[0065] Seal the reaction system, and the oxidation reaction of the cellulose fabrics starts at room temperature

[0066] With the development of the reaction, constantly produced by-products accumulate on the materials of the cellulose fabrics. During the reaction, sonicate for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products.

[0067] After 24-hour reaction, close the valves 4 of the feed pipe 1 and the air outlet 3, open the liquid outlet 7, and introduce N.sub.2 gas through the air inlet 2 to discharge the reaction solution into the storage tank.

[0068] Open the valves 4 of the feed pipe 1 and the air outlet 3, introduce cyclohexane into the reaction equipment for washing, and then discharge the liquid after sonicating for 5 minutes.

[0069] Use the ethanol water solution with the mass percent of 50% for immersion and washing, and discharging the liquid after sonicating for 5 minutes. When the pH of the effluent after washing is equal to 5, use anhydrous ethanol for immersion and washing again, and discharge the liquid after sonicating for 5 minutes.

[0070] Introduce the dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose.

[0071] The completely dried products are the hemostatic gauze with high stability and absorptivity. The gauze is stored and packed in N.sub.2 atmosphere.

[0072] The carbonyl content of the products is 18. 5%, and the warranty period is 2 years.

Embodiment 2

[0073] The preparation apparatus of the invention for hemostatic gauze with high stability and absorptivity is adopted, where the fiber fineness of the raw material of the cellulose fabrics is 2 deniers, and the fabric weight is 200 g/m.sup.2.

[0074] The process adopting the apparatus to prepare hemostatic gauze with high stability and absorptivity includes following steps

[0075] Place the cellulose fabrics with a weight of 1000 g on the reaction apparatus.

[0076] Place and stack up the stainless steel plates 6 layer by layer within the tank body, and put on the tank cover, where the space between the tank cover and the tank body is sealed with the PTFE gasket 11 and the sealing is tightened with the nut 12.

[0077] Open the valves 4 of the feed pipe 1 and the air outlet 3, connect the air outlet 3 to the tail gas absorber, and add the dilute sodium hydroxide solution with the concentration of 1% to a specific position where all cellulose fabrics are completely immersed.

[0078] Sonicate for 1 hour to obtain the oxidized raw material of the cellulose fabrics.

[0079] After discharging the reaction solution, add demin-water three times to a position where the cellulose fabrics are completely immersed, and then discharge the liquid after sonicating for 10 minutes.

[0080] Empty the wash water when it is neutral and add the anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharge the liquid after sonicating for 10 minutes.

[0081] Dry with N.sub.2 gas, and obtain the preprocessed material of the cellulose fabrics after fully drying.

[0082] Introduce the methyl cyclohexane through the feed pipe 1, where the water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicate for 10 minutes to empty the air in the reaction system. Reserve for further use.

[0083] Introduce NO.sub.2 gas into the reaction system, and make the concentration of the NO.sub.2 gas to be 0.5 mol/L in the oxidation reaction system.

[0084] Seal the reaction system, and the oxidation reaction of the cellulose fabrics starts at room temperature

[0085] With the development of the reaction, constantly produced by-products accumulate on the material of the cellulose fabrics. During the reaction, sonicate for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products.

[0086] After 12-hour reaction, close the valves 4 of the feed pipe 1 and the air outlet 3, open the liquid outlet 7, and introduce N.sub.2 gas through the air inlet 2 to discharge the reaction solution into the storage tank.

[0087] Open the valves 4 of the feed pipe 1 and the air outlet 3, introduce methyl cyclohexane into the reaction equipment, and then discharge the liquid after sonicating for 5 minutes.

[0088] Use the ethanol water solution with the mass percent of 75% for immersion and washing, and discharge the liquid after sonicating for 5 minutes. When the pH of the effluent after washing is equal to 6, use anhydrous ethanol for immersion and washing again, and discharge the liquid after sonicating for 5 minutes.

[0089] Introduce the dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose.

[0090] The completely dried products are the hemostatic gauze with high stability and absorptivity. The gauze is stored and packed in N.sub.2 atmosphere.

[0091] The carbonyl content of the products is 23. 5%, and the warranty period is 2 years.

Embodiment 3

[0092] The preparation apparatus of the invention for hemostatic gauze with high stability and absorptivity is adopted, where the fiber fineness of the raw material of the cellulose fabrics is 5 deniers, and the fabric weight is 500 g/m.sup.2.

[0093] The process adopting the apparatus to prepare hemostatic gauze with high stability and absorptivity includes following steps:

[0094] Place the cellulose fabrics with a weight of 1000 g on the reaction equipment.

[0095] Place and stack up the stainless steel plates 6 layer by layer within the tank body, and put on the tank cover, where the space between the tank cover and the tank body is sealed with the PTFE gasket 11 and the sealing is tightened with the nut 12.

[0096] Open the valves 4 of the feed pipe 1 and the air outlet 3, connect the air outlet 3 to the tail gas absorber, and add the dilute sodium hydroxide solution with the concentration of 5% to a specific position where all cellulose fabrics are completely immersed.

[0097] Sonicate for 0.5 hour to obtain the oxidized raw material of the cellulose fabrics.

[0098] After discharging the reaction solution, add demin-water three times to a position where the cellulose fabrics are completely immersed, and then discharge the liquid after sonicating for 10 minutes.

[0099] Empty the wash water when it is neutral, and add the anhydrous ethanol solvent until the cellulose fabrics are completely immersed, and then discharge the liquid after sonicating for 10 minutes.

[0100] Dry with N.sub.2 gas, and obtain the preprocessed material of the cellulose fabrics after fully drying.

[0101] Introduce the anhydrous cyclohexane through the feed pipe 1, where the water content in the system is strictly controlled as less than 0.3%, to a position where the cellulose fabrics are completely immersed, and then sonicate for 10 minutes to empty the air in the reaction system. Reserve for further use.

[0102] Introduce NO.sub.2 gas into the reaction system, and make the concentration of the NO.sub.2 gas to be 2.1 mol/L in the oxidation reaction system.

[0103] Seal the reaction system, and the oxidation reaction of the cellulose fabrics starts at room temperature.

[0104] With the development of the reaction, constantly produced by-products accumulate on the materials of the cellulose fabrics. During the reaction, sonicate for 5 minutes every 30 minutes to accelerate the reaction and remove the by-products.

[0105] After 4-hour reaction, close the valves 4 of the feed pipe 1 and the air outlet 3, and open the liquid outlet 7, and introduce N.sub.2 gas through the air inlet 2 to discharge the reaction solution into the storage tank.

[0106] Open the valves 4 of the feed pipe 1 and the air outlet 3, introduce cyclohexane into the reaction equipment for washing, and then discharge the liquid after sonicating for 5 minutes.

[0107] Use the ethanol water solution with the mass percent of 95% for immersion and washing, and discharge the liquid after sonicating for 5 minutes. When the pH of the effluent after washing is equal to 7, use anhydrous ethanol for immersion and washing again, and discharging the liquid after sonicating for 5 minutes.

[0108] Introduce the dry N.sub.2 gas into the reaction equipment to dry the obtained oxidized regenerated cellulose.

[0109] The completely dried products are the hemostatic gauze with high stability and absorptivity. The gauze is stored and packed in N.sub.2 atmosphere.

[0110] The carbonyl content of the products is 20.0%, and the warranty period is 2 years.

[0111] In the end, it is to be noted that what is illustrated is only the embodiments of the invention. Apparently, the invention is not limited to the embodiments but can include more variations. Any variation directly inferred from or associated with the disclosures of the invention by those of ordinary skill in the art should be considered within the protection scope of the invention.