QUINOLYL PHOSPHINE OXIDE COMPOUND, AND COMPOSITION AND APPLICATION THEREOF

Abstract

The present invention relates to a compound of formula (I), a method for using the compound as an EGFR inhibitor, and a pharmaceutical composition comprising the compound. The compound can be used for treatment, prevention or alleviation of diseases or disorders such as cancer or infection.

##STR00001##

Claims

1. A compound of formula I, or a stereoisomer, a tautomer, a deuterated compound, a pharmaceutically acceptable salt, a prodrug, a chelate, a non-covalent complex, or a solvate thereof: ##STR00338## wherein, R is each independently selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —NR′R″, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —(CH.sub.2).sub.p(O(CH.sub.2).sub.q).sub.rCH.sub.3, —C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, aryl, heteroaryl, —CR.sup.7═CR.sup.8 and ##STR00339## wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, 3-6 membered heterocyclyl, aryl and heteroaryl are optionally substituted by halogen, OH, NH.sub.2, aryl, heteroaryl, —C.sub.1-6 alkyl, or —C.sub.3-6 cycloalkyl; R′, R″, R.sup.7, R.sup.8 and R.sup.9 are each independently selected from the group consisting of H, CN, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, aryl, heteroaryl, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl, or 3-6 membered heterocyclyl; R.sup.1 is selected from the group consisting of H, halogen, CN, —NR.sup.10R.sup.11, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl, and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; R.sup.10 and R.sup.11 are each independently selected from H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl; R.sup.2, R.sup.3 and R.sup.6 are each independently selected from the group consisting of H, halogen, CN, —NR.sup.12R.sup.13, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; and R.sup.2, R.sup.3 and R.sup.6 are not H at the same time; R.sup.12 and R.sup.13 are each independently selected from the group consisting of H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl; R.sup.4 and R.sup.5 are each independently selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —NR.sup.14R.sup.15, —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl, and 3-8 membered heterocyclyl; wherein, the —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-8 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, substituted 3-6 membered heterocyclyl, aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.4 and R.sup.5 are not H at the same time; R.sup.14 and R.sup.15 are each independently selected from the group consisting of H, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl, and —C.sub.3-6 heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and —C.sub.3-6 heterocyclyl are optionally substituted by —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.16R.sup.17, —C.sub.3-6 heterocyclyl, or heterocyclyl substituted by one or more C.sub.1-6 alkyl; and R.sup.16 and R.sup.17 are each independently selected from H and —C.sub.1-6 alkyl; n is an integer selected from 1 to 3; p is an integer selected from 1 to 3; q is an integer selected from 0 to 3; and r is an integer selected from 1 to 3.

2. The compound of claim 1, wherein n is 1; R is each independently selected from the group consisting of halogen, CN, NO.sub.2, OH, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, heteroaryl, and ##STR00340## R.sup.1 is selected from halogen, CN, —NR.sup.10R.sup.11 and OH: R.sup.2 and R.sup.3 are independently selected from the group consisting of H, halogen, CN, —NR.sup.12R.sup.13, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl, and 3-6 membered heterocyclyl: wherein, the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; and R.sup.2 and R.sup.3 are not H at the same time; R.sup.4 and R.sub.5 are each independently selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —NR.sup.14R.sup.15, —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl, and 3-6 membered heterocyclyl: wherein the —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl, and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, substituted 3-6 membered heterocyclyl, aryl, or heteroaryl; and R.sup.4 and R.sup.5 are not H at the same time; R.sup.6 is selected from the group consisting of H, CN, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl: wherein the —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocycyl are optionally substituted with halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; and R.sup.14 and R.sup.15 are each independently selected from H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl.

3. (canceled)

4. The compound of claim 1, wherein R is each independently selected from the group consisting of halogen, CN, NO.sub.2, OH, —CF.sub.3, —CH.sub.3, —CH.sub.2CH.sub.3, —CH.sub.2CH.sub.2CH.sub.3, —CH(CH.sub.3).sub.2, —CH.sub.2CH(CH.sub.3).sub.2, ##STR00341## R.sup.1 is halogen: wherein said halogen is fluorine, chlorine, bromine or iodine: R.sup.2 is selected from H, —C.sub.1-6 alkyl, and —C.sub.1-6 alkoxy; R.sup.3 is H or —C.sub.1-6 alkoxy; R.sup.4 is selected from the group consisting of —NR.sup.14R.sup.15, aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl: wherein the aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15, aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; R.sup.5 is selected from the group consisting of H, halogen, CN, —C.sub.1-6 alkyl, heteroaryl, and —C.sub.1-6 alkoxy: wherein the —C.sub.1-6 alkyl, heteroaryl, and —C.sub.1-6 alkoxy are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15, aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.6 is selected from H, CN, CH.sub.3, CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, ##STR00342##

5.-8. (canceled)

9. The compound of claim 1, wherein R.sup.2 is selected from H, —CH.sub.3 and —OCH.sub.3; R.sup.3 is H or —OCH.sub.3: R.sup.4 is selected from the group consisting of ##STR00343## ##STR00344## ##STR00345## ##STR00346## and R.sup.5 is selected from H, CN, CH.sub.3, CH.sub.2CH.sub.3, F, OCH.sub.3, ##STR00347##

10.-19. (canceled)

20. The compound of claim 1, wherein the compound of formula I, or a stereoisomer, a tautomer, a deuterated compound, a pharmaceutically acceptable salt, a prodrug, a chelate, a non-covalent complex, or a solvate thereof is represented by formula II: ##STR00348## wherein, R is each independently selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —NR′R″, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —(CH.sub.2).sub.p(O(CH.sub.2).sub.q).sub.rCH.sub.3, —C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, aryl, heteroaryl, —CR.sup.7═CR.sup.8 and ##STR00349## wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, 3-6 membered heterocyclyl, aryl and heteroaryl are optionally substituted by halogen, OH, NH.sub.2, aryl, heteroaryl, —C.sub.1-6 alkyl, or —C.sub.3-6 cycloalkyl; R′, R″, R.sup.7, R.sup.8 and R.sup.9 are each independently selected from the group consisting of H, CN, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, aryl, heteroaryl, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl, or 3-6 membered heterocyclyl; R.sup.1 is selected from the group consisting of H, halogen, CN, —NR.sup.10R.sup.11, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; R.sup.10 and R.sup.11 are each independently selected from the group consisting of H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl; R.sup.2 is selected from the group consisting of H, halogen, CN, —NR.sup.12R.sup.13, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; and R.sup.2, R.sup.3 and R.sup.6 are not H at the same time; R.sup.12 and R.sup.13 are each independently selected from the group consisting of H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl; R.sup.4 and R.sup.5 are each independently selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —NR.sup.14R.sup.15, —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-8 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-8 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15, aryl, substituted aryl, heteroaryl, or heteroaryl substituted with one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.4 and R.sup.5 are not H at the same time; R.sup.14 and R.sup.15 are each independently selected from the group consisting of H, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl, and —C.sub.3-6 heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and —C.sub.3-6 heterocyclyl are optionally substituted by —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.16R.sup.17, —C.sub.3-6 heterocyclyl, or heterocyclyl substituted by one or more C.sub.1-6 alkyl; and R.sup.16 and R.sup.17 are each independently selected from H and —C.sub.1-6 alkyl; n is an integer selected from 1 to 3; p is an integer selected from 1 to 3; q is an integer selected from 0 to 3; and r is an integer selected from 1 to 3.

21. The compound of claim 20, wherein n is 1; R is each independently selected from the group consisting of halogen, CN, NO.sub.2, OH, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, heteroaryl, and ##STR00350## R.sup.1 is selected from halogen, CN, —NR.sup.10R.sup.11 and OH; R.sup.2 is selected from the group consisting of H, halogen, CN, —NR.sup.12R.sup.13, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl: wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl: R.sup.12 and R.sup.13 are each independently selected from the group consisting of H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl: R.sup.4 is selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —NR.sup.14R.sup.15 aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl: wherein the aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heteroacyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15 aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.5 is selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —C.sub.1-6 alkyl, aryl, heteroaryl, and —C.sub.1-6 alkoxy: wherein the —C.sub.1-6 alkyl, aryl, heteroaryl, and —C.sub.1-6 alkoxy are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15, aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15.

22. (canceled)

23. The compound of claim 20, wherein R is each independently selected from the group consisting of halogen, CN, NO.sub.2, OH, —CF.sub.3, —CH.sub.3, —CH.sub.2CH.sub.3, —CH.sub.2CH.sub.2CH.sub.3, —CH(CH.sub.3).sub.2, —CH.sub.2CH(CH.sub.3).sub.2, ##STR00351## R.sup.1 is halogen: wherein said halogen is fluorine, chlorine, bromine or iodine: R.sup.2 is selected from H, —C.sub.1-6 alkyl and —C.sub.1-6 alkoxy; R.sup.4 is selected from the group consisting of —NR.sup.14R.sup.15 aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl: wherein the aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15, aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.5 is selected from the group consisting of H, halogen, CN, —C.sub.1-6 alkyl, heteroaryl, and —C.sub.1-6 alkoxy: wherein the —C.sub.1-6 alkyl, heteroaryl, and —C.sub.1-6 alkoxy are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15 aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15.

24. (canceled)

25. (canceled)

26. The compound of claim 20, wherein R.sup.1 is fluorine or bromine; R.sup.2 is —C.sub.1-6 alkoxy: R.sup.4 is selected from the group consisting of ##STR00352## ##STR00353## ##STR00354## ##STR00355## and R.sup.5 is selected H, CN, CH.sub.3, CH.sub.2CH.sub.3, F, OCH.sub.3, ##STR00356##

27.-36. (canceled)

37. The compound of claim 1, wherein the compound of formula I, or a stereoisomer, a tautomer, a deuterated compound, a pharmaceutically acceptable salt, a prodrug, a chelate, a non-covalent complex, or a solvate thereof is represented by formula III: ##STR00357## wherein, R.sup.1 is selected from the group consisting of H, halogen, CN, —NR.sup.10R.sup.11, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; R.sup.10 and R.sup.11 are each independently selected from H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl; R.sup.2 is selected from the group consisting of H, halogen, CN, —NR.sup.12R.sup.13, OH, —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-6 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, or —C.sub.1-6 alkyl; R.sup.12 and R.sup.13 are each independently selected from H, —C.sub.1-6 alkyl and —C.sub.3-6 cycloalkyl; R.sup.4 and R.sup.5 are each independently selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —NR.sup.14R.sup.15, —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-8 membered heterocyclyl; wherein the —C.sub.1-6 alkyl, aryl, heteroaryl, —C.sub.1-6 alkoxy, —C.sub.3-6 cycloalkyl and 3-8 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15, aryl, substituted aryl, heteroaryl, or heteroaryl substituted with one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.4 and R.sup.5 are not H at the same time; and R.sup.14 and R.sup.15 are each independently selected from the group consisting of H, —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl, and —C.sub.3-6 heterocyclyl; wherein the —C.sub.1-6 alkyl, —C.sub.3-6 cycloalkyl and —C.sub.3-6 heterocyclyl are optionally substituted by —C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.16R.sup.17, —C.sub.3-6 heterocyclyl, or heterocyclyl substituted by one or more C.sub.1-6 alkyl; wherein, R.sup.16 and R.sup.17 are each independently selected from H and —C.sub.1-6 alkyl.

38. The compound of claim 37, wherein R.sup.1 is halogen; wherein said halogen is fluorine, chlorine, bromine or iodine; R.sup.2 is selected from —C.sub.1-6 alkyl and —C.sub.1-6 alkoxy; R.sup.4 is selected from the group consisting of —NR.sup.14R.sup.15 aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-8 membered heterocyclyl: wherein the aryl, heteroaryl, —C.sub.3-6 cycloalkyl and 3-8 membered heterocyclyl are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15 aryl substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; R.sup.5 is selected from the group consisting of H, halogen, CN, NO.sub.2, OH, —C.sub.1-6 alkyl, aryl, heteroaryl, and —C.sub.1-6 alkoxy: wherein the —C.sub.1-6 alkyl, aryl, heteroaryl, and —C.sub.1-6 alkoxy are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15 aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.14 and R.sup.15 are each independently selected from H and —C.sub.1-6 alkyl: wherein the —C.sub.1-6 alkyl is optionally substituted by —C.sub.1-6 alkoxy, —NR.sup.16R.sup.17, —C3 heterocyclyl, or heterocyclyl substituted by one or more C.sub.1-6 alkyl: wherein, R.sup.16 and R.sup.17 are each independently selected from H and —C.sub.1-6 alkyl.

39. The compound of claim 37, wherein R.sup.1 is fluorine or bromine; R.sup.2 is —C.sub.1-6 alkoxy: R.sup.4 is 3-8 membered heterocyclyl: wherein the 3-8 membered heterocyclyl is optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15 aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15; and R.sup.5 is selected from the group consisting of H, halogen, CN, —C.sub.1-6 alkyl, heteroaryl, and —C.sub.1-6 alkoxy: wherein the —C.sub.1-6 alkyl, heteroaryl, and —C.sub.1-6 alkoxy are optionally substituted by halogen, OH, NH.sub.2, —C.sub.1-6 alkyl, halogen-substituted C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, —C.sub.1-6 alkoxy, —NR.sup.14R.sup.15, —C.sub.3-6 cycloalkyl, substituted C.sub.3-6 cycloalkyl, 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted by one or more of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxo, and —NR.sup.14R.sup.15, aryl, substituted aryl, heteroaryl, or heteroaryl substituted by one or more of C.sub.1-6 alkyl, hydroxy-substituted C.sub.1-6 alkyl, oxo, C.sub.1-6 alkoxy, and —NR.sup.14R.sup.15.

40. (canceled)

41. (canceled)

42. The compound of claim 37, wherein R.sup.2 is —CH.sub.3 or —OCH.sub.3; R.sup.4 is selected from the group consisting of ##STR00358## ##STR00359## ##STR00360## ##STR00361## R.sup.5 is selected from H, CN, CH.sub.3, CH.sub.2CH.sub.3, F, OCH.sub.3, ##STR00362##

43.-49. (canceled)

50. The compound of claim 1, wherein the compound of formula I is selected from the group consisting of: (6-((5-bromo-2-((5-methoxy-2-methyl-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide; 5-((5-bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinebenzonitrile; (6-((5-bromo-2-((2-ethyl-5-methoxy-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-cyclopropyl-5-methoxy-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-isopropyl-5-methoxy-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((3-methoxy-5-methyl-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-methoxy-2-methyl-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-(1-ethyl-1H-pyrazol-4-yl)-2-methoxy-4-morpholinophenyl)amino)pyrimidine-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-(4-(dimethylamino)piperidin-1-yl)-5-methoxy-2-methylphenyl)amino)pyrimidine-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; 5-((5-bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methylpiperazin-1-yl)benzonitrile; (6-((5-bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethynylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethynylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-methoxy-2-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethynylquinolin-5-yl)dimethylphosphine oxide; 6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-5-(dimethylphosphine oxide)quinoline-2-formonitrile; (6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-fluoro-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2,5-dimethoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; 5-((5-bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)benzonitrile; (6-((5-bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-methoxy-2-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-cyclopropyl-5-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; 2-((5-bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)benzonitrile; (6-((5-bromo-2-((5-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-ethyl-2-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((3-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-ethyl-2-methoxy-4-(1′-methyl-[4,4′-bipiperidin]-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-ethyl-5-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-2-methoxy-5-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-methoxy-4-(4-methoxypiperidin-1-yl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-isopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-fluoro-2-methyl-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2,5-dimethyl-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-2-methoxy-5-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-(4-cyclopropylpiperazin-1-yl)-2-methoxy-5-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-5-methoxy-2-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-methoxy-2-methyl-4′-(4-methylpiperazin-1-yl)-[1,1′-biphenyl]-4-yl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)quinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-propylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-4-(4-(2-methoxypyridin-4-yl)piperazin-1-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyridin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-4-(4-(2-methoxypyrimidin-5-yl)piperazin-1-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-(4-(5-(dimethylamino)pyrazin-2-yl)piperazin-1-yl)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(2-methyl-2H-1,2,3-triazol-4-yl)-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(2-methyl-2H-1,2,3-triazol-4-yl)-4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(thiazol-2-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-4-(4-(6-methoxypyrazin-2-yl)piperazin-1-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; 6-(4-(4-((5-bromo-4-((2-cyclopropyl-5-(dimethylphosphoryl)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-5-methoxy-2-(1-methyl-1H-pyrazol-4-yl)phenyl)piperazin-1-yl)-1-methylpyridin-2(1H)-one; (6-((5-bromo-2-((4-(4-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)piperazin-1-yl)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(((1-methylpiperidine-4-yl)methyl)amino)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyridin-3-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyrazin-2-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinopiperidine-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyrimidin-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(3-methyl-3,6-diazabicyclo[3.1.1]heptyl-6-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; 4-(4-(4-((5-bromo-4-((2-cyclopropyl-5-(dimethylphosphoryl)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-5-methoxy-2-(1-methyl-1H-pyrazol-4-yl)phenyl)piperazin-1-yl)pyridin-2(1H)one; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrrol-3-yl)-4-(4-(4-methylpiperazine-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (2-cyclopropyl-6-((5-fluoro-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)aminopyrimidin-4-yl)amino)quinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(1-methylpiperidine-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; (6-((5-bromo-2-((5-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide; and (6-((5-bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(4-methylpiperazine-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide.

51. A pharmaceutical composition, comprising: the compound of formula I, or a stereoisomer, a tautomer, a deuterated compound, a pharmaceutically acceptable salt, a prodrug, a chelate, a non-covalent complex, or a solvate thereof of claim 1, as the active ingredient; and at least one pharmaceutically acceptable adjuvant.

52. (canceled)

53. A method for treating EGFR-driven cancer, comprising administering a therapeutically effective amount of the compound of formula I, or a stereoisomer, a tautomer, a deuterated compound, a pharmaceutically acceptable salt, a prodrug, a chelate, a non-covalent complex, or a solvate thereof of claim 1, to a patient in need thereof.

54. The method of claim 53, wherein the EGFR-driven cancer is characterized by the presence of one or more mutations selected from the group consisting of: (i) C797S, (ii) L858R and C797S, (iii) C797S and T790M, (iv) L858R, T790M, and C797S, and (v) Δ19del, T790M and C797S.

55. The method of claim 54, wherein the EGFR-driven cancer is colon cancer, stomach cancer, thyroid cancer, lung cancer, leukemia, pancreatic cancer, melanoma, brain cancer, kidney cancer, prostate cancer, ovarian cancer, or breast cancer.

56. The method of claim 55, wherein the lung cancer is non-small cell lung cancer carrying the EGFR.sup.L858T/T790M/C797S or EGFR.sup.Δ19del/T790M/C797S mutation.

57.-61. (canceled)

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0209] FIG. 1, FIGURE showing the half effective dose ED.sub.50 of Comparative Example 1.

EXAMPLES

[0210] It can be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are intended to limit any claimed subject matter. All parts and percentages are by weight and all temperatures are in degrees Celsius unless otherwise specified. The compounds described herein can be obtained from commercial sources or synthesized by conventional methods as shown below using commercially available raw materials and reagents.

[0211] The following abbreviations have been used in the examples:

[0212] AcOH: acetic acid;

[0213] DIEA: N,N-diisopropylethylamine;

[0214] DMF: N,N-dimethylformamide;

[0215] DMSO: dimethyl sulfoxide;

[0216] EA: ethyl acetate;

[0217] HEPES: 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;

[0218] Xantphos: 4,5-bis(diphenylphosphine)-9,9-dimethylxanthene;

[0219] Pd(OAc).sub.2: Palladium acetate

[0220] n-BuOH: n-butanol;

[0221] PTSA: p-toluenesulfonic acid;

[0222] PTLC: preparative thin layer chromatography;

[0223] LCMS: liquid chromatography-mass spectrometry;

[0224] h or hrs: hour(s);

[0225] Pd/C: palladium on activated carbon;

[0226] MeOH: methanol;

[0227] NMP: N-methyl-2-pyrrolidone;

[0228] TLC: thin layer chromatography;

[0229] Pd(dppf)Cl.sub.2: 1,1′-bis(diphenylphosphino)ferrocene palladium dichloride;

[0230] Pd(PPh.sub.3).sub.4: tetrakis(triphenylphosphine)palladium;

[0231] Pd-Ruphos G.sub.3: methanesulfonato(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)(2-amino-1,1′-biphenyl)-2-yl)palladium(II);

[0232] Ruphos: 2-dicyclohexylphosphine-2′,6′-diisopropoxybiphenyl;

[0233] Cs.sub.2CO.sub.3: cesium carbonate;

[0234] ACN: acetonitrile.

Example 1 Synthesis of Compound J-001

(6-((5-Bromo-2-((5-methoxy-2-methyl-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide

[0235] ##STR00024##

Step 1: Synthesis of Compound 1-2

[0236] ##STR00025##

[0237] In a 100 ml single-neck flask, compound 1-1 (25 g, 172.23 mmol) was dissolved in concentrated sulfuric acid (100 mL), and concentrated nitric acid (16.28 g, 258.34 mmol) was added dropwise at 0° C. The mixture was stirred at room temperature for 2 hours. It was monitored by TLC until the raw material reacted completely. The reaction was quenched by adding the solution slowly into 2 L of ice water, and a pale yellow solid was precipitated. The reaction solution was stirred for 1 hour and filtered. The filter cake was washed with 1 L of water, collected, and dried to obtain compound 1-2 (24.5 g, 128.84 mmol, yield: 74.81%). MS: 191.04 [M+H].sup.+

Step 2: Synthesis of Compound 1-3

[0238] ##STR00026##

[0239] In a 500 ml single-neck flask, compound 1-2 (24.5 g, 128.84 mmol) was dissolved in phosphorus oxychloride (200 mL), heated to 100° C. and stirred overnight. It was monitored by LCMS until the raw material reacted completely. The reaction solution was cooled to room temperature, concentrated and the residue was poured into 1 L of ice water, stirred for 0.5 hour, and filtered. The filter cake was washed with 1 L of water, collected and dried to obtain compound 1-3 (25 g, 119.85 mmol, yield: 93.02%).

Step 3: Synthesis of Compound 1-4

[0240] ##STR00027##

[0241] In a 500 ml single-neck flask, compound 1-3 (25 g, 119.85 mmol) was dissolved in 150 mL of ethanol. 30 mL of H.sub.2O was added, followed by adding iron powder (33.47 g, 599.23 mmol) and ammonium chloride (32.05 g, 599.23 mmol). The reaction solution was heated to 90° C., stirred for 3 hours, cooled to room temperature and filtered through diatomite. The filter cake was washed with ethanol for several times and the filtrate was collected and concentrated. The residue was purified by Flash silica gel column (A:DCM, B:MeOH; methanol 0-5%, 20 minutes) to obtain compound 1-4 (16.9 g, 94.62 mmol, yield: 78.95%). MS: 179.03 [M+H].sup.+

Step 4: Synthesis of Compound 1-5

[0242] ##STR00028##

[0243] In a 250 ml single-neck flask, compound 1-4 (16.9 g, 94.62 mmol) was dissolved in glacial acetic acid (320 mL) and iodine chloride (18.43 g, 113.54 mmol) in acetic acid (80 mL) was added dropwise at room temperature. After the addition was completed, stirring was continued at room temperature for 2 hours. It was monitored by LCMS until the raw material reacted completely. 500 ml of n-hexane was added to dilute the reaction solution and a solid was precipitated, which was then filtered. The filter cake was washed with n-hexane, dried by suction, dissolved in a mixed solvent of DCM:MeOH=10:1, washed twice with saturated sodium carbonate solution, twice with saturated sodium thiosulfate solution, and once with saturated sodium chloride solution successively, dried, filtered, and concentrated. The residue was purified by Flash silica gel column (A:DCM, B:MeOH; methanol 0-5%, 20 minutes) to obtain compound 1-5 (22.23 g, 73.00 mmol, yield: 77.16%). MS: 304.93 [M+H].sup.+

Step 5: Synthesis of Compound 1-6

[0244] ##STR00029##

[0245] In a 250 ml single-neck flask, compound 1-5 (10.00 g, 32.84 mmol), dimethylphosphine oxide (2.69 g, 34.48 mmol), Xantphos (3.80 g, 6.57 mmol), palladium acetate (737.27 mg, 3.28 mmol) and anhydrous potassium phosphate (13.94 g, 65.68 mmol) were dissolved in 1,4-dioxane (100 mL). Nitrogen replacement was performed for three times. The mixture was heated to 100° C. and stirred overnight. The temperature was lowered and the reaction solution was filtered. The filtrate was concentrated. The residue was purified by Flash silica gel column, being eluting first with petroleum ether/ethyl acetate (ethyl acetate 0-50%, 10 minutes) and then with dichloromethane/methanol (methanol 0-6%, 20 minutes), to obtain compound 1-6 (6.18 g, 24.27 mmol, yield: 73.90%). MS: 255.04 [M+H].sup.+

Step 6: Synthesis of Compound 1-7

[0246] ##STR00030##

[0247] Compound 1-6 (4 g, 15.71 mmol), cyclopropylboronic acid (5.40 g, 62.83 mmol), palladium acetate (352.65 mg, 1.57 mmol), triphenylphosphine (0.82 g, 3.14 mmol) and Cs.sub.2CO.sub.3 (15.35 g, 47.12 mmol) were added to a mixed solvent of toluene (60 mL) and H.sub.2O (10 mL). The mixture was heated to 100° C. under nitrogen protection, and stirred for 12 hours. It was monitored by LCMS until the reaction was completed and the reaction solution was cooled to room temperature. The reaction solution was added with 40 mL of water and the layers were separated. The organic phase was collected. The aqueous phase was extracted with ethyl acetate (3×30 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, concentrated, and purified by column chromatography (dichloromethane:methanol=15:1) to obtain a yellow solid compound 1-7 (2.2 g, 8.45 mmol, yield: 53.81%). MS: 261.11 [M+H].sup.+

Step 7: Synthesis of Compound 1-8

[0248] ##STR00031##

[0249] Compound 1-7 (2.2 g, 8.45 mmol), 5-bromo-2,4-dichloropyrimidine (3.85 g, 16.91 mmol), DIEA (3.28 g, 25.36 mmol, 4.42 mL) and n-BuOH (40 mL) were successively added into a reaction flask. The mixture was heated to 120° C. and stirred for 10 hours. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature and filtered. The filter cake was dried to obtain a pale yellow solid compound 1-8 (2.4 g, 5.31 mmol, yield: 62.86%). MS: 451.00 [M+H].sup.+

Step 8: Synthesis of Compound 1-10

[0250] ##STR00032##

[0251] Compound 1-9 (3.00 g), morpholine (2.11 g), K.sub.2CO.sub.3 (4.48 g) and DMSO (30 mL) were successively added to a reaction flask and the temperature was raised to 90° C. The mixture stirred under heating for 12 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was poured into 100 mL of water, and a solid was precipitated and filtered by suction. The filter cake was washed with water and dried to obtain a yellow solid compound 1-10 (3.5 g). MS: 253.11 [M+H].sup.+

Step 9: Synthesis of Compound 1-11

[0252] ##STR00033##

[0253] Compound 1-10 (3.50 g) and MeOH (60 mL) were added to a reaction flask. The reaction flask was then vacuumized, purged with nitrogen, added with Pd/C (1.00 g, 10%), vacuumized, and purged with H2. The reaction was carried out at room temperature for 3 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. After filtration by suction, the filter cake was washed with methanol (20 mL). The organic phase was collected and concentrated to obtain a reddish-brown liquid compound 1-11 (3.1 g). MS: 223.14 [M+H].sup.+

Step 10: Synthesis of Compound J-001

[0254] ##STR00034##

[0255] Compound 1-8 (100 mg), compound 1-11 (49.3 mg), p-toluenesulfonic acid (57.3 mg) and n-BuOH (3 mL) were successively added to a reaction flask and the mixture was stirred at 110° C. overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, spin-dried, added with saturated aqueous Na.sub.2CO.sub.3 solution (10 mL), extracted with dichloromethane (3×10 mL), dried with anhydrous sodium sulfate, filtered, and spin-dried. The crude product was purified by PTLC (dichloromethane:methanol=10:1) to obtain compound J-001 (55 mg). MS: 637.16 [M+H].sup.+

Example 2 Synthesis of Compound J-002

5-((5-Bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinebenzonitrile

[0256] ##STR00035##

Step 1: Synthesis of Compound 2-2

[0257] ##STR00036##

[0258] Compound 2-1 (1 g, 4.00 mmol), morpholine (696.90 mg, 8.00 mmol), K.sub.2CO.sub.3 (1.66 g, 12.00 mmol) and DMSO (10 mL) were successively added to a reaction flask and the temperature was raised to 100° C. The mixture stirred under heating for 12 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was poured into water (20 mL) and filtered by suction. The filter cake was washed with water and dried to obtain a yellow solid compound 2-2 (1.1 g, 3.47 mmol). MS: 317.01 [M+H].sup.+

Step 2: Synthesis of Compound 2-3

[0259] ##STR00037##

[0260] Compound 2-2 (1.1 g, 3.47 mmol), Zn(CN).sub.2 (610.94 mg, 5.20 mmol) and Pd(PPh.sub.3).sub.4 (400.81 mg, 346.86 μmol) were dissolved in DMF (10 mL) and nitrogen replacement was performed for three times. The reaction was carried out at 120° C. under microwave for 2 hours and was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, added with water (20 mL), filtered, washed with a small amount of water and washed with dichloromethane (15 mL). The layers were separated. The organic phase are dried with anhydrous sodium sulfate, filtered, concentrated, and purified by column chromatography (dichloromethane:methanol=15:1) to obtain a white solid compound 2-3 (700 mg, 2.66 mmol, yield: 76.66%). MS: 264.00 [M+H].sup.+

Step 3: Synthesis of Compound 2-4

[0261] ##STR00038##

[0262] Compound 2-3 (700 mg, 2.66 mmol) was dissolved in ethanol (10 mL) and water (5 mL), followed by adding reduced iron powder (1.49 g, 26.59 mmol) and NH.sub.4C1 (1.42 g, 26.59 mmol), and the reaction was carried out at 80° C. for 2 hours. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, added with 10 mL of saturated Na.sub.2CO.sub.3 aqueous solution, extracted with dichloromethane (3×10), dried, filtered and concentrated to obtain a pale yellow solid compound 2-4 (500 mg, 2.14 mmol, yield: 80.61%). MS: 234.12 [M+H].sup.+

Step 4: Synthesis of Compound J-002

[0263] ##STR00039##

[0264] Compound 2-4 (55 mg, 235.78 μmol), compound 1-8 (117.15 mg, 259.36 μmol), p-toluenesulfonic acid (64.96 mg, 377.25 μmol) and n-BuOH (2 mL) were successively added to a reaction flask and the mixture was stirred at 110° C. overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, spin-dried, added with saturated aqueous Na.sub.2CO.sub.3 solution (10 mL), extracted with dichloromethane (3×10 mL), dried with anhydrous sodium sulfate, filtered and spin-dried. The crude product was purified by PTLC (dichloromethane:methanol=10:1) to obtain compound J-002 (10 mg, 15.42 μmol, yield: 6.54%). MS: 648.14 [M+H].sup.+

Example 3 Synthesis of Compound J-003

(6-((5-Bromo-2-((2-ethyl-5-methoxy-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide

[0265] ##STR00040##

Step 1: Synthesis of Compound 3-2

[0266] ##STR00041##

[0267] Compound 3-1 (500 mg, 2.00 mmol), potassium trifluoro(vinyl)borate (401.81 mg, 3.00 mmol), Pd(dppf)Cl.sub.2 (163.31 mg, 199.98 μmol), K.sub.2CO.sub.3 (690.99 mg, 5.00 mmol), dioxane (60 mL) and H.sub.2O (15 mL) were successively added to a reaction flask and the reaction was carried out at 100° C. for 6 hours. The reaction solution was cooled to room temperature, added with 25 mL water, extracted with ethyl acetate, dried with anhydrous sodium sulfate, filtered, and spin-dried. The crude product was subjected to column chromatography (dichloromethane/methanol=15:1) to obtain the yellow solid target product 3-2 (300 mg, 1.52 mmol, yield: 76.09%).

Step 3: Synthesis of Compound 3-3

[0268] ##STR00042##

[0269] The synthesis method of compound 3-3 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 3-2. MS of compound 3-3: 265.11 [M+H].sup.+

Step 3: Synthesis of Compound 3-4

[0270] ##STR00043##

[0271] The synthesis method of compound 3-4 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 3-3. MS of compound 3-4: 237.15 [M+H].sup.+

Step 4: Synthesis of Compound J-003

[0272] ##STR00044##

[0273] The synthesis method of compound J-003 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 3-4. MS of compound J-003: 651.18 [M+H].sup.+

[0274] .sup.1H NMR (500 MHz, DMSO-d.sub.6) δ 12.16 (s, 11H), 8.64 (s, 11H), 8.36 (s, 11H), 8.30 (d, J=8.9 Hz, 1H), 8.15 (s, 1H), 7.53 (s, 1H), 7.41 (d, J=8.9 Hz, 1H), 6.83 (s, 1H), 6.71 (s, 1H), 3.80-3.75 (m, 4H), 3.64 (s, 3H), 3.05-2.76 (m, 4H), 2.46-2.40 (m, 2H), 2.29-2.24 (m, 1H), 2.00 (s, 3H), 1.97 (s, 3H), 1.09-0.96 (m, 7H).

Example 4 Synthesis of Compound J-004

(6-((5-Bromo-2-((2-cyclopropyl-5-methoxy-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide

[0275] ##STR00045##

Step 1: Synthesis of Compound 4-1

[0276] ##STR00046##

[0277] The synthesis method of compound 4-1 is the same as that of compound 3-2, except that the starting compound potassium trifluoro(vinyl)borate is replaced with cyclopropylboronic acid.

Step 2: Synthesis of Compound 4-2

[0278] ##STR00047##

[0279] The synthesis method of compound 4-2 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 4-1. MS of compound 4-2: 279.13 [M+H].sup.+

Step 3: Synthesis of Compound 4-3

[0280] ##STR00048##

[0281] The synthesis method of compound 4-3 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 4-2. MS of compound 4-3: 249.15 [M+H].sup.+

Step 4: Synthesis of Compound J-004

[0282] ##STR00049##

[0283] The synthesis method of compound J-004 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 4-3. MS of compound J-004: 663.18 [M+H].sup.+

[0284] .sup.1H NMR (500 MHz, DMSO-d6) δ 12.14 (s, 1H), 8.63 (s, 1H), 8.38 (d, J=9.2 Hz, 1H). 8.31 (d, J=8.9 Hz, 1H), 8.18 (s, 1H), 7.54 (s, 1H). 7.41 (d, J=9.0 Hz, 1H), 6.90 (s, 1H), 6.35 (s, 1H), 3.79-3.60 (m, 4H), 3.58 (s, 3H), 2.99-2.59 (m, 4H), 2.31-2.23 (m, 11H), 2.00 (s, 3H), 1.97 (s, 3H), 1.89-1.81 (m, 11H), 1.08-0.95 (m, 4H), 0.76-0.73 (m, 2H) 0.49-0.47 (m, 2H).

Example 5 Synthesis of Compound J-005

(6-((5-Bromo-2-((2-isopropyl-5-methoxy-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide

[0285] ##STR00050##

Step 1: Synthesis of Compound 5-1

[0286] ##STR00051##

[0287] The synthesis method of compound 5-1 is the same as that of compound 3-2, except that the starting compound potassium trifluoro(vinyl)borate is replaced by 4,4,5,5-tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborane.

Step 2: Synthesis of Compound 5-2

[0288] ##STR00052##

[0289] The synthesis method of compound 5-2 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 5-1. MS of compound 5-2: 279.13 [M+H].sup.+

Step 3: Synthesis of Compound 5-3

[0290] ##STR00053##

[0291] The synthesis method of compound 5-3 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 5-2. MS of compound 5-3: 251.17 [M+H].sup.+

Step 4: Synthesis of Compound J-005

[0292] ##STR00054##

[0293] The synthesis method of compound J-005 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 5-3. MS of compound J-005: 665.19 [M+H].sup.+

Example 6 Synthesis of Compound J-006

(6-((5-Bromo-2-((3-methoxy-5-methyl-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide

[0294] ##STR00055##

Step 1: Synthesis of Compound 6-2

[0295] ##STR00056##

[0296] The synthesis method of compound 6-2 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 6-1. MS of compound 6-2: 253.11 [M+H].sup.+

Step 2: Synthesis of Compound 6-3

[0297] ##STR00057##

[0298] The synthesis method of compound 6-3 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 6-2. MS of compound 6-3: 223.14 [M+H].sup.+

Step 3: Synthesis of Compound J-006

[0299] ##STR00058##

[0300] The synthesis method of compound J-006 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 6-3. MS of compound J-006: 637.16 [M+H].sup.+

Example 7 Synthesis of Compound J-007

(6-((5-Bromo-2-((5-methoxy-2-methyl-4-morpholinylphenyl)amino)pyrimidin-4-yl)amino)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-5-yl)dimethylphosphine oxide

[0301] ##STR00059##

Step 1: Synthesis of Compound 7-2

[0302] ##STR00060##

[0303] Compound 1-6 (500 mg, 1.96 mmol), compound 7-1 (490.23 mg, 2.36 mmol), Pd(dppf)Cl.sub.2 (160.34 mg, 196.35 μmol), K.sub.2CO.sub.3 (678.43 mg, 4.91 mmol), dioxane (9 mL) and H.sub.2O (3 mL) were successively added to a reaction flask. Nitrogen replacement was performed for three times and the mixture was heated to 100° C. and stirred for 6 hours. It was monitored by LCMS until the reaction was completed and the reaction solution was cooled to room temperature. The reaction solution was added with 15 mL of water and the layers were separated. The organic phase was collected, and the aqueous phase was extracted with ethyl acetate (3×20 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, spin-dried, and purified by column chromatography (dichloromethane:methanol=15:1) to obtain a yellow solid compound 7-2 (400 mg, 1.33 mmol, yield: 67.84%). MS: 301.11 [M+H].sup.+

Step 2: Synthesis of Compound 7-3

[0304] ##STR00061##

[0305] The synthesis method of compound 7-3 is the same as that of compound 1-8, except that the starting compound 1-7 is replaced by compound 7-2. MS of compound 7-3: 491.01 [M+H].sup.+

Step 3: Synthesis of Compound J-007

[0306] ##STR00062##

[0307] The synthesis method of compound J-007 is the same as that of compound J-001, except that the starting compound 1-8 is replaced by compound 7-3. MS of compound J-007: 677.17 [M+H].sup.+

Example 8 Synthesis of Compound J-008

(6-((5-Bromo-2-((5-(1-ethyl-1H-pyrazol-4-yl)-2-methoxy-4-morpholinophenyl)amino)pyrimidine-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0308] ##STR00063##

Step 1: Synthesis of Compound 8-2

[0309] ##STR00064##

[0310] The synthesis method of compound 8-2 is the same as that of compound 7-2, except that compound 1-6 is replaced by compound 2-1, and compound 7-1 is replaced by compound 8-1. MS of compound 8-2: 266.09 [M+H].sup.+

Step 2: Synthesis of Compound 8-3

[0311] ##STR00065##

[0312] The synthesis method of compound 8-3 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 8-2. MS of compound 8-3: 333.15 [M+H].sup.+

Step 3: Synthesis of Compound 8-4

[0313] ##STR00066##

[0314] The synthesis method of compound 8-4 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 8-3. MS of compound 8-4: 303.17 [M+H].sup.+

Step 4: Synthesis of Compound J-008

[0315] ##STR00067##

[0316] Compound 1-8 (149 mg), compound 8-4 (100 mg), p-toluenesulfonic acid (114 mg) and n-BuOH (2 mL) were successively added to a reaction flask and the temperature was raised to 110° C. The mixture was stirred under heating for 4 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was added with water (10 mL) and extracted with dichloromethane (3×10 mL). The organic phase was washed with saturated brine (3×10 mL), and dried with anhydrous sodium sulfate. The solvent was removed, and the residue was separated and purified by PTLC (dichloromethane:methanol=15: 1) to obtain a brown solid compound J-008 (7.2 mg). MS: 717.20 [M+H].sup.+

Example 9 Synthesis of Compound J-009

(6-((5-Bromo-2-((4-(4-(dimethylamino)piperidin-1-yl)-5-methoxy-2-methylphenyl)amino)pyrimidine-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0317] ##STR00068##

Step 1: Synthesis of Compound 9-2

[0318] ##STR00069##

[0319] The synthesis method of compound 9-2 is the same as that of compound 3-2, except that the starting compound potassium trifluoro(vinyl)borate is replaced with compound 9-1.

Step 2: Synthesis of Compound 9-3

[0320] ##STR00070##

[0321] The synthesis method of compound 9-3 is the same as that of compound 1-10, except that the raw material compound 1-9 is replaced by compound 9-2, and the compound morpholine is replaced by 4-dimethylaminopiperidine. MS of compound 9-3: 294.17 [M+H].sup.+

Step 3: Synthesis of Compound 9-4

[0322] ##STR00071##

[0323] The synthesis method of compound 9-4 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 9-3. MS of compound 9-4: 264.20 [M+H].sup.+

Step 4: Synthesis of Compound J-009

[0324] ##STR00072##

[0325] The synthesis method of compound J-009 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 9-4. MS of compound J-009: 678.22 [M+H].sup.+

Example 10 Synthesis of Compound J-010

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0326] ##STR00073##

Step 1: Synthesis of Compound 10-2

[0327] ##STR00074##

[0328] The synthesis method of compound 10-2 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 10-1, and morpholine is replaced by N-methylpiperazine. MS of compound 10-2: 266.14 [M+H].sup.+

Step 2: Synthesis of Compound 10-3

[0329] ##STR00075##

[0330] The synthesis method of compound 10-3 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 10-2. MS of compound 10-3: 236.17 [M+H].sup.+

Step 3: Synthesis of Compound J-010

[0331] ##STR00076##

[0332] The synthesis method of compound J-010 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 10-3. MS of compound J-010: 650.19 [M+H].sup.+

Example 11 Synthesis of Compound J-011

(6-((5-Bromo-2-((5-ethyl-2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0333] ##STR00077##

Step 1: Synthesis of Compound 11-2

[0334] ##STR00078##

[0335] The synthesis method of compound 11-2 is the same as that of compound 10-2, except that the starting compound 10-1 is replaced by compound 11-1. MS of compound 11-2: 280.16 [M+H].sup.+

Step 2: Synthesis of Compound 11-3

[0336] ##STR00079##

[0337] The synthesis method of compound 11-3 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 11-2. MS of compound 11-3: 250.18 [M+H].sup.+

Step 3: Synthesis of Compound J-011

[0338] ##STR00080##

[0339] The synthesis method of compound J-011 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 11-3. MS of compound J-011: 664.21 [M+H].sup.+

Example 12 Synthesis of Compound J-012

5-((5-Bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methylpiperazin-1-yl)benzonitrile

[0340] ##STR00081##

Step 1: Synthesis of Compound 12-1

[0341] ##STR00082##

[0342] The synthesis method of compound 12-1 is the same as that of compound 2-2, except that morpholine is replaced by N-methylpiperazine. MS of compound 12-1: 330.04 [M+H].sup.+

Step 2: Synthesis of Compound 12-2

[0343] ##STR00083##

[0344] The synthesis method of compound 12-2 is the same as that of compound 2-3, except that the starting compound 2-2 is replaced by compound 12-1. MS of compound 12-2: 277.12 [M+H].sup.+

Step 3: Synthesis of Compound 12-3

[0345] ##STR00084##

[0346] The synthesis method of compound 12-3 is the same as that of compound 2-4, except that the starting compound 2-3 is replaced by compound 12-2. MS of compound 12-3: 247.15 [M+H].sup.+

Step 4: Synthesis of Compound J-012

[0347] ##STR00085##

[0348] The synthesis method of compound J-012 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 12-3. MS of compound J-012: 661.17 [M+H].sup.+

Example 13 Synthesis of Compound J-014

(6-((5-Bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethynylquinolin-5-yl)dimethylphosphine oxide

[0349] ##STR00086##

Step 1: Synthesis of Compound 13-1

[0350] ##STR00087##

[0351] Compound 1-6 (500 mg) was dissolved in toluene (10 ml) in a reaction flask, followed by adding trimethylethynylsilicon (290 mg), Xantphos (227 mg), CuI (112 mg), Pd(dppf)Cl.sub.2 (138 mg) and triethylamine (595 mg). The mixture was heated to 100° C. under nitrogen protection and stirred overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature and concentrated. The residue was mixed with silica gel and purified by flash silica gel column (DCM/MeOH=10/1, MeOH 0-5%, 20 minutes). The eluant was concentrated to obtain a solid compound 13-1 (390 mg, yield: 62.78%). MS: 317.12 [M+H].sup.+

Step 2: Synthesis of Compound 13-2

[0352] ##STR00088##

[0353] The synthesis method of compound 13-2 is the same as that of compound 1-8, except that the starting compound 1-7 is replaced by compound 13-1. MS of compound 13-2: 507.01 [M+H].sup.+

Step 3: Synthesis of Compound 13-4

[0354] ##STR00089##

[0355] Compound 11-1 (3.00 g), compound 13-3 (4.14 g), K.sub.2CO.sub.3 (6.24 g) and DMSO (30 mL) were successively added to a reaction flask and the temperature was raised to 90° C. The mixture was stirred under heating for 12 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was poured into water (100 mL) and filtered by suction. The filter cake was washed with water and dried to obtain a yellow solid compound 13-4 (4.20 g). MS: 363.23 [M+H].sup.+

Step 4: Synthesis of Compound 13-5

[0356] ##STR00090##

[0357] Compound 13-4 (4.20 g), Pd/C (1.00 g, 10%) and MeOH (60 mL) were successively added to a reaction flask which was then purged with H2. The reaction solution was stirred at room temperature for 3 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was filtrated by suction and washed with methanol (20 mL). The organic phase was collected and the solvent was removed to obtain a reddish-brown liquid compound 13-5 (3.5 g). MS: 333.26 [M+H].sup.+

Step 5: Synthesis of Compound 13-6

[0358] ##STR00091##

[0359] The synthesis method of compound 13-6 is the same as that of compound J-001, except that compound 1-11 is replaced by compound 13-5, and compound 1-8 is replaced by compound 13-2. MS of compound 13-6: 803.29 [M+H].sup.+

Step 6: Synthesis of Compound J-014

[0360] ##STR00092##

[0361] Compound 13-6 (44 mg, 54.74 μmol) was dissolved in anhydrous methanol (5 mL) in a reaction flask, followed by adding solid potassium carbonate (23 mg, 166.42 μmol). The reaction solution was stirred at room temperature for 1 hour. It was monitored by LCMS until the reaction was completed. DCM and water were added to the reaction solution and the layers were separated by stirring. The organic phase was washed once with water, dried, filtered, and concentrated. The residue was dissolved in a small amount of dichloromethane and purified by PTLC (DCM/MeOH=10/1) to obtain compound J-014 (18.3 mg, 25.01 μmol, yield: 45.69%). MS: 731.25 [M+H].sup.+

Example 14 Synthesis of Compound J-013

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1 yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethynylquinolin-5-yl)dimethylphosphine oxide

[0362] ##STR00093##

Step 1: Synthesis of Compound 14-1

[0363] ##STR00094##

[0364] Compound 10-1 (1 g, 5.40 mmol), compound 13-3 (1.19 g, 6.48 mmol), K.sub.2CO.sub.3 (1.49 g, 10.8 mmol) and DMSO (10 mL) were successively added to the reaction flask and the temperature was raised to 90° C. The mixture was stirred under heating overnight. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was added with 50 mL of DCM, washed with water (100×2 mL), washed with 100 mL of saturated brine, dried with anhydrous magnesium sulfate, concentrated, slurried with diethyl ether, filtered by suction, and dried to obtain a yellow solid compound 14-1 (1.61 g, 4.62 mmol). MS: 349.22 [M+H].sup.+

Step 2: Synthesis of Compound 14-2

[0365] ##STR00095##

[0366] Compound 14-1 (1.61 g, 4.62 mmol), Pd/C (0.5 g, 10%) and MeOH (30 ML) were successively added to a reaction flask, which was then purged with H2. The reaction solution was stirred at room temperature for 3 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was filtrated by suction and washed with methanol (20 mL). The organic phase was collected and the solvent was removed to obtain target product compound 14-2 (1.3 g, 4.08 mmol). MS: 319.24 [M+H].sup.+

Step 3: Synthesis of Compound 14-3

[0367] ##STR00096##

[0368] The synthesis method of compound 14-3 is the same as that of compound 13-6, except that the starting compound 13-5 is replaced by compound 14-2. MS of compound 14-3: 789.27 [M+H].sup.+

Step 4: Synthesis of Compound J-013

[0369] ##STR00097##

[0370] Compound 14-3 (32 mg, 40.52 μmol) was dissolved in anhydrous methanol (5 mL) in the reaction flask, followed by adding K.sub.2CO.sub.3 (17 mg, 123.01 μmol). The reaction solution was stirred at room temperature for 1 hour. It was monitored by LCMS until the reaction was completed. DCM and water were added to the reaction solution and the layers were separated by stirring. The organic phase was washed once with water, dried, filtered, and concentrated. The residue was dissolved in a small amount of dichloromethane and purified by PTLC (DCM/MeOH=10/1) to obtain compound J-013 (8.4 mg, 11.71 μmol, yield: 28.89%). MS: 717.24 [M+H].sup.+

Example 15 Synthesis of Compound J-015

(6-((5-Bromo-2-((5-methoxy-2-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethynylquinolin-5-yl)dimethylphosphine oxide

[0371] ##STR00098##

Step 1: Synthesis of Compound 15-1

[0372] ##STR00099##

[0373] The synthesis method of compound 15-1 is the same as that of compound 1-10, except that the starting compound morpholine is replaced by compound 13-3. MS of compound 15-1: 349.22 [M+H].sup.+

Step 2: Synthesis of Compound 15-2

[0374] ##STR00100##

[0375] The synthesis method of compound 15-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 15-1. MS of compound 15-2: 319.24 [M+H].sup.+

Step 3: Synthesis of Compound 15-3

[0376] ##STR00101##

[0377] The synthesis method of compound 15-3 is the same as that of compound 13-6, except that the starting compound 13-5 is replaced by compound 15-2. MS of compound 15-3: 789.27 [M+H].sup.+

Step 4: Synthesis of Compound J-015

[0378] ##STR00102##

[0379] The synthesis method of compound J-015 is the same as that of compound J-014, except that the starting compound 13-6 is replaced by compound 15-3. MS of compound J-015: 717.24 [M+H].sup.+

Example 16 Synthesis of Compound J-016

6-((5-Bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-5-(dimethylphosphine oxide)quinoline-2-formonitrile

[0380] ##STR00103##

Step 1: Synthesis of Compound 16-1

[0381] ##STR00104##

[0382] Compound 1-6 (600 mg, 2.36 mmol) was dissolved in N,N-dimethylformamide (5 mL) in a reaction flask, followed by adding zinc cyanide (552.00 mg, 4.70 mmol), Pd(PPh.sub.3).sub.4 (272.00 mg, 235.38 μmol) successively. The mixture was heated under microwave to 100° C. under nitrogen protection and stirred for 0.5 hour. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, diluted with water, and extracted twice with DCM. The organic phases were combined, washed three times with water, then washed once with saturated aqueous sodium chloride solution, dried, and filtered. The filtrate was concentrated and mixed with silica gel and purified by Flash silica gel column (DCM/MeOH, MeOH 0-10%, 20 min). The eluant was concentrated to obtain a solid compound 16-1 (300 mg, 1.22 mmol, yield: 51.92%). MS: 246.07 [M+H].sup.+

Step 2: Synthesis of Compound 16-2

[0383] ##STR00105##

[0384] The synthesis method of compound 16-2 is the same as that of compound 1-8, except that the starting compound 1-7 is replaced by compound 16-1. MS of compound 16-2: 435.97 [M+H].sup.+

Step 3: Synthesis of Compound J-016

[0385] ##STR00106##

[0386] The synthesis method of compound J-016 is the same as that of compound 13-6, except that the starting compound 13-2 is replaced by compound 16-2. MS of compound J-016: 732.25 [M+H].sup.+

Example 17 Synthesis of Compound J-017

(6-((5-Bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2(1-methyl-1H-pyrazol-4-yl)quinolin-5-yl)dimethylphosphine oxide

[0387] ##STR00107##

Step 1: Synthesis of Compound J-017

[0388] ##STR00108##

[0389] Compound 13-5 (135.24 mg, 406.75 μmol), compound 7-3 (200 mg, 406.75 μmol), p-toluenesulfonic acid (104.95 mg, 610.12 μmol) and n-BuOH (8 mL) were successively added to a reaction flask and the mixture was stirred at 120° C. overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, spin-dried, added with saturated aqueous K.sub.2CO.sub.3 solution (10 mL), extracted with dichloromethane (3×10 mL), dried with anhydrous sodium sulfate, filtered and spin-dried. The crude product was purified by column chromatography (dichloromethane:methanol=8:1) to obtain compound J-017 (98.6 mg, 125.17 μmol, yield: 30.77%). MS: 787.29 [M+H].sup.+

Example 18 Synthesis of Compound J-018

(6-((5-Bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0390] ##STR00109##

Step 1: Synthesis of Compound J-018

[0391] ##STR00110##

[0392] Compound 13-5 (80.0 mg, 240.61 μmol), compound 1-8 (119.55 mg, 264.68 μmol), p-toluenesulfonic acid (82.87 mg, 481.23 μmol) and n-BuOH (2 mL) were successively added to a reaction flask. The mixture was heated to 110° C. and stirred overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, spin-dried, added with saturated aqueous Na.sub.2CO.sub.3 solution (10 mL), extracted with dichloromethane (3×10 mL), dried with anhydrous sodium sulfate, filtered and spin-dried. The crude product was purified by PTLC (dichloromethane:methanol=10:1) to obtain compound J-018 (98 mg, 131.07 μmol, yield: 54.47%). MS: 747.28 [M+H].sup.+

[0393] .sup.1H NMR (500 MHz, DMSO-d6) δ 11.76 (s, 1H), 8.49 (d, J=8.8 Hz, 1H), 8.20 (s, 2H), 8.06 (d, J=9.7 Hz, 1H), 7.74 (d, J=9.2 Hz, 1H), 7.44 (d, J=8.9 Hz, 1H), 7.27 (s, 1H), 6.76 (s, 1H), 3.75 (s, 3H), 2.98-2.91 (m, 2H), 2.71-2.52 (m, 5H), 2.49-2.12 (m, 12H), 1.98 (s, 3H), 1.96 (s, 3H) 1.89-1.79 (m, 2H), 1.61-1.43 (m, 2H), 1.24-1.19 (m, 3H), 1.09-1.01 (m, 4H).

Example 19 Synthesis of Compound J-019

(6-((5-Bromo-2-((5-fluoro-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0394] ##STR00111##

Step 1: Synthesis of Compound 19-2

[0395] ##STR00112##

[0396] Compound 19-1 (500 mg, 2.00 mmol), compound 13-3 (439.86 mg, 2.40 mmol), Pd-Ruphos G.sub.3 (186.64 mg, 400 μmol), Ruphos (167.46 mg, 200 μmol), Cs.sub.2CO.sub.3 (1.23 g, 4.00 mmol) and toluene (15 mL) were successively added to a reaction flask. The mixture was heated to 100° C. and stirred for 5 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was cooled to room temperature, filtered by suction, spin-dried, and purified with silica gel column (dichloromethane:methanol=15:1) to obtain a yellow solid compound 19-2 (4.20 g). MS: 353.19 [M+H].sup.+

Step 2: Synthesis of Compound 19-3

[0397] ##STR00113##

[0398] The synthesis method of compound 19-3 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 19-2. MS of compound 19-3: 323.22 [M+H].sup.+

Step 3: Synthesis of Compound J-019

[0399] ##STR00114##

[0400] The synthesis method of compound J-019 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 19-3. MS of compound J-019: 737.24 [M+H].sup.+

Example 20 Synthesis of Compound J-020

(6-((5-Bromo-2-((2,5-dimethoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0401] ##STR00115##

Step 1: Synthesis of Compound 20-2

[0402] ##STR00116##

[0403] Compound 20-1 (5.0 g, 23.04 mmol) was dissolved in HOAc (15 mL), and HNO.sub.3 (2 mL) was slowly added dropwise under an ice-water bath. The reaction was carried out at room temperature for 15 minutes. The reaction solution was poured into 40 mL of ice-water and a solid was precipitated and filtered. The filter cake was washed with 10 mL of water for 3 times, washed with 5 mL of diethyl ether, and dried to obtain a white solid compound 20-2 (5 g, 19.08 mmol, yield: 82.83%).

Step 2: Synthesis of Compound 20-3

[0404] ##STR00117##

[0405] The synthesis method of compound 20-3 is the same as that of compound 19-2, except that the starting compound 19-1 is replaced by compound 20-2. MS of compound 20-3: 365.21 [M+H].sup.+

Step 3: Synthesis of Compound 20-4

[0406] ##STR00118##

[0407] The synthesis method of compound 20-4 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 20-3. MS of compound 20-4: 335.24 [M+H].sup.+

Step 4: Synthesis of Compound J-020

[0408] ##STR00119##

[0409] The synthesis method of compound J-020 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 20-4. MS of compound J-020: 749.26 [M+H].sup.+

Example 21 Synthesis of Compound J-021

5-((5-Bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)benzonitrile

[0410] ##STR00120##

Step 1: Synthesis of Compound 21-1

[0411] ##STR00121##

[0412] The synthesis method of compound 21-1 is the same as that of compound 2-2, except that the starting compound morpholine is replaced by compound 13-3. MS of compound 21-1: 413.11 [M+H].sup.+

Step 2: Synthesis of Compound 21-2

[0413] ##STR00122##

[0414] The synthesis method of compound 21-2 is the same as that of compound 2-3, except that the compound 2-2 is replaced with compound 21-1. MS of compound 21-2: 360.20 [M+H].sup.+

Step 3: Synthesis of Compound 21-3

[0415] ##STR00123##

[0416] The synthesis method of compound 21-3 is the same as that of compound 2-4, except that the compound 2-3 is replaced with compound 21-2. MS of compound 21-3: 330.22 [M+H].sup.+

Step 4: Synthesis of Compound J-021

[0417] ##STR00124##

[0418] The synthesis method of compound J-021 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 21-3. MS of compound J-021: 744.25 [M+H].sup.+

Example 22 Synthesis of Compound J-022

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0419] ##STR00125##

Step 1: Synthesis of Compound J-022

[0420] ##STR00126##

[0421] Compound 14-2 (67.05 mg, 210.54 μmol), compound 1-8 (104.61 mg, 231.59 μmol), p-toluenesulfonic acid (65.26 mg, 378.97 μmol) and n-BuOH (2 mL) were successively added to a reaction flask. The mixture was heated to 100° C. and stirred overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, spin-dried, added with saturated aqueous Na.sub.2CO.sub.3 solution (10 mL), extracted with dichloromethane (3×10 mL), dried with anhydrous sodium sulfate, filtered, and spin-dried. The crude product was purified by PTLC (dichloromethane:methanol=10:1) to obtain compound J-022 (24 mg, 32.71 μmol, yield: 15.54%). MS: 733.27 [M+H].sup.+

[0422] .sup.1H-NMR (500 MHz, DMSO-d6): δ 11.88 (s, 1H), 8.44 (d, J=8.5 Hz, 1H), 8.27-8.26 (m, 1H), 8.19 (s, 1H), 8.03 (s, 1H), 7.75 (d, J=9.0 Hz, 1H), 7.42 (d, J=8.5 Hz, 1H), 7.24 (br, 1H), 6.69 (s, 1H), 3.75 (s, 3H), 3.02-3.00 (m, 2H), 2.63-2.59 (m, 2H), 2.51-2.50 (m, 4H), 2.30-2.26 (m, 6H), 2.14 (s, 3H), 1.98 (d, J=13.5 Hz, 6H), 1.90 (s, 3H), 1.84-1.82 (m, 2H) 1.55-1.52 (m, 2H), 1.06-1.05 (m, 4H).

Example 23 Synthesis of Compound J-023

(6-((5-Bromo-2-((5-methoxy-2-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-J-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0423] ##STR00127##

Step 1: Synthesis of Compound J-023

[0424] ##STR00128##

[0425] The synthesis method of compound J-023 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 15-2. MS of compound J-023: 733.27 [M+H].sup.+

Example 24 Synthesis of Compound J-024

(6-((5-Bromo-2-((2-cyclopropyl-5-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0426] ##STR00129##

Step 1: Synthesis of Compound 24-1

[0427] ##STR00130##

[0428] Compound 3-1 (2.00 g, 8.00 mmol), cyclopropylboronic acid (3.44 g, 39.97 mmol), Pd(dppf)Cl.sub.2 (0.58 g, 0.80 mmol), K.sub.2CO.sub.3 (2.21 g, 15.99 mmol) were added to a mixed solvent of dioxane (20 mL) and H.sub.2O (4 mL). The mixture was heated to 100° C. under nitrogen protection and stirred for 12 hours. It was monitored by TLC until the reaction was completed and the reaction solution was cooled to room temperature. The reaction solution was added with water (30 mL) and extracted with ethyl acetate (3×30 mL). The organic phase was washed with saturated brine (3×30 mL), dried with anhydrous sodium sulfate, and purified by column chromatography (n-hexane:ethyl acetate=15:1). Pale yellow solid compound 24-1 (1.2 g) was obtained.

Step 2: Synthesis of Compound 24-2

[0429] ##STR00131##

[0430] The synthesis method of compound 24-2 is the same as that of compound 13-4, except that the starting compound 11-1 is replaced by compound 24-1. MS of compound 24-2: 375.23 [M+H].sup.+

Step 3: Synthesis of Compound 24-3

[0431] ##STR00132##

[0432] The synthesis method of compound 24-3 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 24-2. MS of compound 24-3: 345.26 [M+H].sup.+

Step 4: Synthesis of Compound J-024

[0433] ##STR00133##

[0434] The synthesis method of compound J-024 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 24-3. MS of compound J-024: 759.28 [M+H].sup.+

Example 25 Synthesis of Compound J-025

2-((5-Bromo-4-((2-cyclopropyl-5-(dimethylphosphine oxide)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-4-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)benzonitrile

[0435] ##STR00134##

Step 1: Synthesis of Compound 25-1

[0436] ##STR00135##

[0437] The synthesis method of compound 25-1 is the same as that of compound 2-3, except that the starting compound 2-2 is replaced by compound 3-1.

Step 2: Synthesis of Compound 25-2

[0438] ##STR00136##

[0439] The synthesis method of compound 25-2 is the same as that of compound 13-4, except that the starting compound 11-1 is replaced by compound 25-1. MS of compound 25-2: 360.20 [M+H].sup.+

Step 3: Synthesis of Compound 25-3

[0440] ##STR00137##

[0441] The synthesis method of compound 25-3 is the same as that of compound 2-4, except that the starting compound 2-3 is replaced by compound 25-2. MS of compound 25-3: 330.22 [M+H].sup.+

Step 4: Synthesis of Compound J-025

[0442] ##STR00138##

[0443] The synthesis method of compound J-025 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 25-3. MS of compound J-025: 744.25 [M+H].sup.+

Example 26 Synthesis of Compound J-026

(6-((5-Bromo-2-((5-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0444] ##STR00139##

Step 1: Synthesis of Compound 26-1

[0445] ##STR00140##

[0446] The synthesis method of compound 26-2 is the same as that of compound 24-1, except that the starting compound cyclopropylboronic acid is replaced by compound 26-1. MS of compound 26-2: 256.09 [M+H].sup.+

Step 2: Synthesis of Compound 26-3

[0447] ##STR00141##

[0448] The synthesis method of compound 26-3 is the same as that of compound 13-4, except that the starting compound 11-1 is replaced by compound 26-2. MS of compound 26-3: 419.26 [M+H].sup.+

Step 3: Synthesis of Compound 26-4

[0449] ##STR00142##

[0450] The synthesis method of compound 26-4 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 26-3. MS of compound 26-4: 389.28 [M+H].sup.+

Step 4: Synthesis of Compound J-026

[0451] ##STR00143##

[0452] The synthesis method of compound J-026 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 26-4. MS of compound J-026: 803.31 [M+H].sup.+

Example 27 Synthesis of Compound J-027

(6-((5-Bromo-2-((5-ethyl-2-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0453] ##STR00144##

Step 1: Synthesis of Compound 27-2

[0454] ##STR00145##

[0455] The synthesis method of compound 27-2 is the same as that of compound 3-2, except that the starting compound 3-1 is replaced by compound 27-1.

Step 2: Synthesis of Compound 27-3

[0456] ##STR00146##

[0457] The synthesis method of compound 27-3 is the same as that of compound 13-4, except that the starting compound 11-1 is replaced by compound 27-2. MS of compound 27-3: 345.22 [M+H].sup.+

Step 3: Synthesis of Compound 27-4

[0458] ##STR00147##

[0459] The synthesis method of compound 27-4 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 27-3. MS of compound 27-3: 317.26 [M+H].sup.+

Step 4: Synthesis of Compound J-027

[0460] ##STR00148##

[0461] The synthesis method of compound J-027 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 27-4. MS of compound J-027: 731.29 [M+H].sup.+

Example 28 Synthesis of Compound J-028

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-ethylquinolin-5-yl)dimethylphosphine oxide

[0462] ##STR00149##

Step 1: Synthesis of Compound 28-1

[0463] ##STR00150##

[0464] The synthesis method of compound 28-1 is the same as that of compound 7-2, except that compound 7-1 is replaced with potassium trifluoro(vinyl)borate. MS of compound 28-1: 247.09 [M+H].sup.+

Step 2: Synthesis of Compound 28-2

[0465] ##STR00151##

[0466] The synthesis method of compound 28-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 28-1. MS of compound 28-2: 249.11 [M+H].sup.+

Step 3: Synthesis of Compound 28-3

[0467] ##STR00152##

[0468] The synthesis method of compound 28-3 is the same as that of compound 1-8, except that the compound 1-7 is replaced by compound 28-2. MS of compound 28-3: 439.00 [M+H].sup.+

Step 4: Synthesis of Compound J-028

[0469] ##STR00153##

[0470] The synthesis method of compound J-028 is the same as that of compound J-022, except that the starting compound 1-8 is replaced by compound 28-3. MS of compound J-028: 721.27 [M+H].sup.+

Example 29 Synthesis of Compound J-029

(6-((5-Bromo-2-((3-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0471] ##STR00154##

Step 1: Synthesis of Compound 29-1

[0472] ##STR00155##

[0473] The synthesis method of compound 29-1 is the same as that of compound 6-2, except that the starting compound morpholine is replaced by compound 13-3. MS of compound 29-1: 349.22 [M+H].sup.+

Step 2: Synthesis of Compound 29-2

[0474] ##STR00156##

[0475] The synthesis method of compound 29-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 29-1. MS of compound 29-2: 319.24 [M+H].sup.+

Step 3: Synthesis of Compound J-029

[0476] ##STR00157##

[0477] The synthesis method of compound J-029 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 29-2. MS of compound J-029: 733.27 [M+H].sup.+

Example 30 Synthesis of Compound J-030

(6-((5-Bromo-2-((5-ethyl-2-methoxy-4-(1′-methyl-[4,4′-bipiperidin]-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0478] ##STR00158##

Step 1: Synthesis of Compound 30-2

[0479] ##STR00159##

[0480] The synthesis method of compound 30-2 is the same as that of compound 13-4, except that the starting compound 13-3 is replaced by compound 30-1. MS of compound 30-2: 362.24 [M+H].sup.+

Step 2: Synthesis of Compound 30-3

[0481] ##STR00160##

[0482] The synthesis method of compound 30-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound 30-2. MS of compound 30-3: 332.26 [M+H].sup.+

Step 3: Synthesis of Compound J-030

[0483] ##STR00161##

[0484] The synthesis method of compound J-030 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound 30-3. MS of compound J-030: 746.29 [M+H].sup.+

Example 31 Synthesis of Compound J-031

(6-((5-Bromo-2-((2-ethyl-5-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0485] ##STR00162##

Step 1: Synthesis of Compound J-031-2

[0486] ##STR00163##

[0487] Compound 3-1 (500 mg, 2.00 mmol), potassium trifluoro(vinyl)borate (401.81 mg, 3.00 mmol), Pd(dppf)Cl.sub.2 (163.31 mg, 199.98 μmol), K.sub.2CO.sub.3 (690.99 mg, 5.00 mmol), dioxane (60 mL) and H.sub.2O (15 mL) were successively added to a reaction flask. The temperature was raised to 100° C. and the reaction was carried out for 6 hours. The reaction solution was cooled to room temperature, added with 25 mL of water, extracted with ethyl acetate, dried with anhydrous sodium sulfate, filtered, and spin-dried. The crude product was subjected to column chromatography (dichloromethane/methanol=15:1) to obtain the yellow solid target product 3-2 (300 mg, 1.52 mmol, yield: 76.09%).

Step 2: Synthesis of Compound J-031-3

[0488] ##STR00164##

[0489] Compound 3-2 (0.6 g, 3.04 mmol), compound 13-3 (1.11 g, 6.08 mmol), K.sub.2CO.sub.3 (0.84 g, 6.08 mmol) and DMSO (10 mL) were successively added to a reaction flask, and the temperature was raised to 100° C. The mixture was heated and stirred 12 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was poured into water (100 mL) and filtered by suction. The filter cake was washed with water and dried to obtain a yellow solid compound J-031-3 (0.82 g, 2.27 mmol). MS: 361.22 [M+H].sup.+

Step 3: Synthesis of Compound J-031-4

[0490] ##STR00165##

[0491] Compound J-031-3 (0.6 g) and MeOH (30 mL) were added to a reaction flask. The reaction flask was then vacuumized, purged with hydrogen, added with Pd/C (0.5 g, 10%), vacuumized, and purged with H2. The reaction was carried out at room temperature for 3 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. After filtration by suction, the filter cake was washed with methanol (20 mL). The organic phase was collected and concentrated to obtain a reddish-brown liquid compound J-031-4 (0.45 g). MS: 333.26 [M+H].sup.+

Step 4: Synthesis of Compound J-031

[0492] ##STR00166##

[0493] Compound J-031-4 (100 mg), compound 1-8 (78.2 mg), p-toluenesulfonic acid (48.6 mg) and n-BuOH (3 mL) were successively added to a reaction flask, and the mixture was stirred at 110° C. overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, spin-dried, added with saturated aqueous Na.sub.2CO.sub.3 solution (10 mL), extracted with dichloromethane (3×10 mL), dried with anhydrous sodium sulfate, filtered, and spin-dried. The crude product was purified by PTLC (dichloromethane:methanol=10:1) to obtain compound J-031 (23 mg). MS: 747.28 [M+H].sup.+

Example 32 Synthesis of Compound J-032

(6-((5-Bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-2-methoxy-5-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0494] ##STR00167##

Step 1: Synthesis of Compound J-032-2

[0495] ##STR00168##

[0496] Compound 10-1 (1.0 g, 5.40 mmol), compound J-032-1 (1.66 g, 10.80 mmol), K.sub.2CO.sub.3 (1.49 g, 10.8 mmol) and DMSO (10 mL) were successively added to a reaction flask. The mixture was heated 100° C. and stirred 12 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. The reaction solution was poured into water (20 mL) and filtered by suction. The filter cake was washed with water and dried to obtain a yellow solid compound J-032-3 (1.2 g, 3.7 mmol). MS: 320.19 [M+H].sup.+

Step 2: Synthesis of Compound J-032-3

[0497] ##STR00169##

[0498] Compound J-032-2 (0.5 g) and MeOH (30 mL) were added to a reaction flask. The reaction flask was then vacuumized, purged with hydrogen, added with Pd/C (0.5 g, 10%), vacuumized, and purged with H2. The reaction was carried out at room temperature for 3 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. After filtration by suction, the filter cake was washed with methanol (20 mL). The organic phase was collected and concentrated to obtain a reddish-brown liquid compound J-032-3 (0.3 g). MS: 290.22 [M+H].sup.+

Step 3: Synthesis of Compound J-032

[0499] ##STR00170##

[0500] Compound J-032-3 (120 mg), compound 1-8 (82.6 mg), p-toluenesulfonic acid (52.3 mg) and n-BuOH (3 mL) were successively added to a reaction flask, and the mixture was stirred at 110° C. overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature, spin-dried, added with saturated aqueous Na.sub.2CO.sub.3 solution (10 mL), extracted with dichloromethane (3×10 mL), dried with anhydrous sodium sulfate, filtered, and spin-dried. The crude product was purified by PTLC (dichloromethane:methanol=10:1) to obtain compound J-032 (50 mg). MS: 704.24 [M+H].sup.+

Example 33 Synthesis of Compound J-033

(6-((5-Bromo-2-((5-methoxy-4-(4-methoxypiperidin-1-yl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0501] ##STR00171##

Step 1: Synthesis of Compound J-033-1

[0502] ##STR00172##

[0503] The synthesis method of compound J-033-1 is the same as that of compound 1-10, except that the starting compound morpholine is replaced by 4-methoxypiperidine. MS of compound J-033-1: 281.14 [M+H].sup.+

Step 2: Synthesis of Compound J-033-2

[0504] ##STR00173##

[0505] The synthesis method of compound J-033-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-033-1. MS of compound J-033-2: 251.17 [M+H].sup.+

Step 3: Synthesis of Compound J-033

[0506] ##STR00174##

[0507] The synthesis method of compound J-033 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-033-2. MS of compound J-033: 665.19 [M+H].sup.+

Example 34 Synthesis of Compound J-034

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-isopropylquinolin-5-yl)dimethylphosphine oxide

[0508] ##STR00175##

Step 1: Synthesis of Compound J-034-1

[0509] ##STR00176##

[0510] In a reactor with a stirrer and a nitrogen protection device, compound 1-6 (500 mg, 1.96 mmol) and 2-isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborane (1.32 g, 7.85 mmol) were dissolved in water (1 mL) and 1,4-dioxane (5 mL), followed by adding Pd(dppf)Cl.sub.2 (160.34 mg, 196.35 μmol) and K.sub.2CO.sub.3 (678.43 mg, 4.91 mmol) at room temperature. Nitrogen replacement was performed for three times. The mixture was stirred uniformly, heated to 100° C. under an oil bath, and stirred at 100° C. for 1.5 hours. LCMS monitoring showed that the reaction was complete. The reaction solution was cooled to room temperature and concentrated by rotary evaporation. After concentration, organic phase was mixed with silica gel, separated and purified by column with a gradient of PE:EtOAc from 0%-100%, concentrated and dried to obtain a yellow solid compound J-034-1 (400 mg, 1.54 mmol, yield 78.27%). MS: 261.11 [M+H].sup.+

Step 2: Synthesis of Compound J-034-2

[0511] ##STR00177##

[0512] Compound J-034-1 (528.48 mg, 2.03 mmol), methanol (10 mL), Pd/C (178 mg, 10% purity) were successively added to a reaction flask. The mixture was stirred at room temperature for 12 hours under a hydrogen atmosphere. It was monitored by LCMS until the reaction was completed. The reaction solution was filtered and spin-dried to obtain a yellow solid compound J-034-2 (450 mg, 1.72 mmol, 84.50% yield), which was used directly in the next step without purification. MS: 263.12 [M+H].sup.+

Step 3: Synthesis of Compound J-034-3

[0513] ##STR00178##

[0514] The synthesis method of compound J-034-3 is the same as that of compound 1-8, except that the starting compound 1-7 is replaced by compound J-034-2. MS of compound J-034-3: 453.02 [M+H].sup.+

Step 4: Synthesis of Compound J-034

[0515] ##STR00179##

[0516] The synthesis method of compound J-034 is the same as that of compound J-001, except that compound 1-11 is replaced by compound 14-2, and compound 1-8 is replaced by compound J-034-3. MS of compound J-034: 735.28 [M+H].sup.+

Example 35 Synthesis of Compound J-035

(6-((5-Bromo-2-((5-fluoro-2-methyl-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide

[0517] ##STR00180##

Step 1: Synthesis of Compound J-035-2

[0518] ##STR00181##

[0519] The synthesis method of compound J-035-2 is the same as that of compound 1-10, except that starting compound 1-9 is replaced by compound J-035-1. MS of compound J-035-2: 241.09 [M+H].sup.+.

Step 2: Synthesis of Compound J-035-3

[0520] ##STR00182##

[0521] The synthesis method of compound J-035-3 is the same as that of compound 1-11, except that starting compound 1-10 is replaced by compound J-035-2. MS of compound J-035-3: 211.12 [M+H].sup.+.

Step 3: Synthesis of Compound J-035

[0522] ##STR00183##

[0523] The synthesis method of compound J-035 is the same as that of compound J-001, except that compound 1-11 is replaced by compound J-035-3. MS of compound J-035: 625.14 [M+H].sup.+.

Example 36 Synthesis of Compound J-036

(6-((5-Bromo-2-((2,5-dimethyl-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinoline-5-yl)dimethylphosphine oxide

[0524] ##STR00184##

Step 1: Synthesis of Compound J-036-2

[0525] ##STR00185##

[0526] The synthesis method of compound J-036-2 is the same as that of compound 1-10, except that starting compound 1-9 is replaced by compound J-036-1. MS of compound J-036-2: 301.01 [M+H].sup.+.

Step 2: Synthesis of Compound J-036-3

[0527] ##STR00186##

[0528] The synthesis method of compound J-036-3 is the same as that of compound 3-2, except that starting compound 3-1 is replaced by compound J-036-2, and the starting compound potassium trifluoro(vinyl)borate is replaced by methylboronic acid. MS of compound J-036-3: 237.12 [M+H].sup.+.

Step 3: Synthesis of Compound J-036-4

[0529] ##STR00187##

[0530] The synthesis method of compound J-036-4 is the same as that of compound 1-11, except that starting compound 1-10 is replaced by compound J-036-3. MS of compound J-036-4: 207.14 [M+H].sup.+.

Step 4: Synthesis of Compound J-036

[0531] ##STR00188##

[0532] The synthesis method of compound J-036 is the same as that of compound J-001, except that compound 1-11 is replaced by compound J-036-4. MS of compound J-036: 621.17 [M+H].sup.+.

Example 37 Synthesis of Compound J-037

(6-((5-Bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-2-methoxy-5-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0533] ##STR00189##

Step 1: Synthesis of Compound J-037-2

[0534] ##STR00190##

[0535] The synthesis method of compound J-037-2 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 10-1, and the starting compound morpholine is replaced by compound J-032-1. MS of compound J-037-2: 320.19 [M+H].sup.+.

Step 2: Synthesis of Compound J-037-3

[0536] ##STR00191##

[0537] The synthesis method of compound J-037-3 is the same as that of compound 1-11, except that starting compound 1-10 is replaced by compound J-037-2. MS of compound J-037-3: 290.22 [M+H].sup.+.

Step 3: Synthesis of Compound J-037

[0538] ##STR00192##

[0539] The synthesis method of compound J-037 is the same as that of compound J-001, except that compound 1-11 is replaced by compound J-037-3. MS of compound J-037: 704.24 [M+H].sup.+.

Example 38 Synthesis of Compound J-038

(6-((5-Bromo-2-((4-(4-cyclopropylpiperazin-1-yl)-2-methoxy-5-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0540] ##STR00193##

Step 1: Synthesis of Compound J-038-2

[0541] ##STR00194##

[0542] The synthesis method of compound J-038-2 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 10-1, and the starting compound morpholine is replaced by compound J-038-1. MS of compound J-038-2: 292.16 [M+H].sup.+.

Step 2: Synthesis of Compound J-038-3

[0543] ##STR00195##

[0544] The synthesis method of compound J-038-3 is the same as that of compound 1-11, except that starting compound 1-10 is replaced by compound J-038-2. MS of compound J-038-3: 262.18 [M+H].sup.+.

Step 3: Synthesis of Compound J-038

[0545] ##STR00196##

[0546] The synthesis method of compound J-038 is the same as that of compound J-001, except that starting compound 1-11 is replaced by compound J-038-3. MS of compound J-038: 676.21 [M+H].sup.+.

Example 39 Synthesis of Compound J-039

(6-((5-Bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-5-methoxy-2-methylphenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0547] ##STR00197##

Step 1: Synthesis of Compound J-039-1

[0548] ##STR00198##

[0549] The synthesis method of compound J-039-1 is the same as that of compound 1-10, except that the starting compound 1-9 is replaced by compound 9-2, and the starting compound morpholine is replaced by compound J-032-1. MS of compound J-039-1: 320.19 [M+H].sup.+.

Step 2: Synthesis of Compound J-039-2

[0550] ##STR00199##

[0551] The synthesis method of compound J-039-2 is the same as that of compound 1-11, except that starting compound 1-10 is replaced by compound J-039-1. MS of compound J-039-2: 290.22 [M+H].sup.+.

Step 3: Synthesis of Compound J-039

[0552] ##STR00200##

[0553] The synthesis method of compound J-039 is the same as that of compound J-001, except that starting compound 1-11 is replaced by compound J-039-2. MS of compound J-039: 704.24 [M+H].sup.+.

Example 40 Synthesis of Compound J-040

(6-((5-Bromo-2-((5-methoxy-2-methyl-4′-(4-methylpiperazin-1-yl)-[1,1′-biphenyl]-4-yl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0554] ##STR00201##

Step 1: Synthesis of Compound J-040-3

[0555] ##STR00202##

[0556] The synthesis method of compound J-040-3 is the same as that of compound 3-2, except that starting compound 3-1 is replaced by compound J-040-1, and the starting compound potassium trifluoro(vinyl)borate is replaced by the compound J-040-2. MS of compound J-040-3: 342.17 [M+H].sup.+.

Step 2: Synthesis of Compound J-040-4

[0557] ##STR00203##

[0558] The synthesis method of compound J-040-4 is the same as that of compound 1-11, except that starting compound 1-10 is replaced by compound J-040-3. MS of compound J-040-4: 312.20 [M+H].sup.+.

Step 3: Synthesis of Compound J-040

[0559] ##STR00204##

[0560] The synthesis method of compound J-040 is the same as that of compound J-001, except that starting compound 1-11 is replaced by compound J-040-4. MS of compound J-040: 726.22 [M+H].sup.+.

Example 41 Synthesis of Compound J-041

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)quinolin-5-yl)dimethylphosphine oxide

[0561] ##STR00205##

Step 1: Synthesis of Compound J-041-1

[0562] ##STR00206##

[0563] Compound 1-3 (0.5 g) was dissolved in 10 mL of methanol in a 20 ml single-neck bottle, followed by adding palladium on carbon (0.2 g, 10%). The reaction system was vacuumized and purged with hydrogen. The reaction was carried out at room temperature overnight. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. After filtration by suction, the filter cake was washed with methanol (10 mL). The organic phase was collected and concentrated to obtain a reddish-grey solid compound J-041-1 (0.36 g). MS: 145.07 [M+H].sup.+

Step 2: Synthesis of Compound J-041-2

[0564] ##STR00207##

[0565] The synthesis method of compound J-041-2 is the same as that of compound 1-5, except that starting compound 1-4 is replaced by compound J-041-1. MS of compound J-041-2: 270.97 [M+H].sup.+.

Step 3: Synthesis of Compound J-041-3

[0566] ##STR00208##

[0567] The synthesis method of compound J-041-3 is the same as that of compound 1-6, except that starting compound 1-5 is replaced by compound J-041-2. MS of compound J-041-2: 221.08 [M+H].sup.+.

Step 4: Synthesis of Compound J-041-4

[0568] ##STR00209##

[0569] The synthesis method of compound J-041-4 is the same as that of compound 1-8, except that starting compound 1-7 is replaced by compound J-041-3. MS of compound J-041-4: 410.97 [M+H].sup.+.

Step 5: Synthesis of Compound J-041

[0570] ##STR00210##

[0571] The synthesis method of compound J-041 is the same as that of compound J-001, except that starting compound 1-11 is replaced by compound 14-2, and compound 1-8 is replaced by compound J-041-4. MS of compound J-041: 693.24 [M+H].sup.+

Example 42 Synthesis of Compound J-042

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-propylquinolin-5-yl)dimethylphosphine oxide

[0572] ##STR00211##

Step 1: Synthesis of Compound J-042-1

[0573] ##STR00212##

[0574] In a reactor with a stirrer and a nitrogen protection device, compound 1-3 (500 mg, 2.41 mmol) and trans-1-propen-1-yl-boronic acid (414 mg, 4.82 mmol) was dissolved in water (1 mL) and toluene (5 mL), followed by adding Palladium acetate (54 mg, 0.24 mmol), triphenylphosphine (126 mg, 0.48 mmol) and Cs.sub.2CO.sub.3 (1.57 g, 4.82 mmol) at room temperature. Nitrogen replacement was performed for three times. The mixture was stirred uniformly, heated to 100° C. under an oil bath, and reacted overnight. It was monitored by LCMS until the reaction was completed. The reaction solution was cooled to room temperature and concentrated by rotary evaporation. After concentration, the organic phase was mixed with silica gel, separated, purified by column with a gradient of PE:EtOAc from 0%-100%, concentrated, and dried to obtain a yellow solid compound J-042-1 (264 mg, yield 51.17%). MS: 215.07 [M+H].sup.+

Step 2: Synthesis of Compound J-042-2

[0575] ##STR00213##

[0576] Compound J-042-1 (264 mg) was dissolved in 5 mL of methanol in a 20 ml single-neck bottle, followed by adding palladium on carbon (0.1 g, 10%). The reaction system was vacuumized and purged with hydrogen. The reaction was carried out at room temperature for 4 hours. It was monitored by LCMS until the reaction was completed and then the reaction was stopped. After filtration by suction, the filter cake was washed with methanol (10 mL). The organic phase was collected and concentrated to obtain an off-white solid compound J-042-2 (220 mg). MS: 187.12 [M+H].sup.+

Step 3: Synthesis of Compound J-042-3

[0577] ##STR00214##

[0578] The synthesis method of compound J-042-3 is the same as that of compound 1-5, except that starting compound 1-4 is replaced by compound J-042-2. MS of compound J-042-3: 313.01 [M+H].sup.+.

Step 4: Synthesis of Compound J-042-4

[0579] ##STR00215##

[0580] The synthesis method of compound J-042-4 is the same as that of compound 1-6, except that starting compound 1-5 is replaced by compound J-042-3. MS of compound J-042-4: 263.12 [M+H].sup.+.

Step 5: Synthesis of Compound J-041-5

[0581] ##STR00216##

[0582] The synthesis method of compound J-042-5 is the same as that of compound 1-8, except that starting compound 1-7 is replaced by compound J-042-4. MS of compound J-042-5: 453.07 [M+H].sup.+.

Step 6: Synthesis of Compound J-042

[0583] ##STR00217##

[0584] The synthesis method of compound J-042 is the same as that of compound J-001, except that starting compound 1-11 is replaced by compound 14-2, and compound 1-8 is replaced by compound J-042-5. MS of compound J-042: 735.28 [M+H].sup.+

Example 43 Synthesis of Compound J-043

(6-((5-bromo-2-((2-methoxy-4-(4-(2-methoxypyridin-4-yl)piperazin-1-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyridin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0585] ##STR00218##

Step 1: Synthesis of Compound J-043-2

[0586] ##STR00219##

[0587] Compound 2-1 (1.00 g, 4.00 mmol, 1.0 eq), compound J-043-1 (0.82 g, 4.40 mmol, 1.1 eq), anhydrous potassium carbonate (1.106 g, 8.0 mmol, 2.0 eq) and DMSO (10 mL) were mixed uniformly in a 50 ml single-neck flask, and the reaction was carried out at 100° C. for 4 hours. The reaction solution was cooled to room temperature, poured into 50 mL of water, extracted with 30 ml ethyl acetate twice. The organic phases were combined, washed three times with 50 ml water, washed once with 50 ml saturated brine, dried, filtered, and concentrated to obtain compound J-043-2 (1.634 g, 3.93 mmol, yield: 98.25%). MS: 416.07 [M+H].sup.+

Step 2: Synthesis of Compound J-043-4

[0588] ##STR00220##

[0589] Compound J-043-2 (1.134 g, 3.93 mmol), compound 7-1 (0.980 g, 4.71 mmol), anhydrous potassium carbonate (1.086 g, 7.86 mmol) and Pd(dppf)Cl.sub.2.CH.sub.2Cl.sub.2 (1.086 g, 7.86 mmol) was dissolved in 1,4-dioxane/water (20 mL/2 mL) in a 50 ml single-neck flask. The mixture was heated to 100° C. and stirred overnight under nitrogen protection. The reaction solution was cooled to room temperature, concentrated, mixed with silica gel, and purified by flash silica gel column (DCM/MeOH; MeOH from 0-5%, 20 minutes) to obtain compound J-043-4 (1.20 g, 2.87 mmol, yield: 73.03%)). MS: 418.20 [M+H].sup.+.

Step 3: Synthesis of Compound J-043-5

[0590] ##STR00221##

[0591] Compound J-043-4 (1.20 g, 3.93 mmol) was dissolved in dichloromethane (15 mL) in a 50 ml single-neck flask, followed by adding trifluoroformic acid (3 ml). The mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated. The residue was slurried with anhydrous diethyl ether for 0.5 hour and filtered. The filter cake was washed with diethyl ether, collected, and dried to obtain compound J-043-5 (1.12 g, 2.60 mmol, yield: 90.59%). MS: 318.15 [M+H].sup.+.

Step 4: Synthesis of Compound J-043-7

[0592] ##STR00222##

[0593] Compound J-043-5 (200 mg, 0.630 mmol), compound J-043-6 (178 mg, 0.945 mmol), Ruphos (59 mg, 0.126 mmol), Ruphos Pd G.sub.3 (53 mg, 0.063 mmol) and cesium carbonate (616 mg, 1.89 mmol) were dissolved in toluene (5 ml) in a 25 ml single-neck flask. The mixture was heated to 100° C. and stirred overnight under nitrogen protection. The reaction solution was cooled to room temperature and concentrated. The residue was mixed with silica gel and purified by flash silica gel column (DCM/MeOH; MeOH from 0-5%, 20 minutes) to obtain compound J-043-7 (254 mg, 0.600 mmol, yield: 95.24%). MS: 425.19 [M+H].sup.+.

Step 5: Synthesis of Compound J-043-8

[0594] ##STR00223##

[0595] Compound J-043-7 (254 mg, 0.600 mmol) was dissolved in THF (10 mL) in a 50 ml single-neck flask, followed by adding palladium on carbon (150 mg). The reaction system was purged with hydrogen for 3 times and stirred at room temperature for 2 hours under the hydrogen atmosphere. After the reaction was completed, the reaction solution was filtered. The filter cake was washed with THF. The filtrate was collected and concentrated to obtain compound J-043-8 (200 mg, 0.507 mmol, yield: 84.5%). MS: 395.21 [M+H].sup.+.

Step 6: Synthesis of Compound J-043

[0596] ##STR00224##

[0597] Compound J-043-8 (164 mg, 0.415 mmol), compound 1-8 (156 mg, 0.346 mmol) and PTSA (149 mg, 0.864 mmol) were dissolved in n-butanol (5 ml) in a 25 ml single-neck bottle. The mixture was heated to 110° C. and stirred for 3 hours. After the raw materials reacted completely, the reaction solution was cooled to room temperature, concentrated, and added with 30 ml of water. The pH was adjusted to about 10 with an aqueous potassium carbonate solution and the reaction solution was extracted twice with DCM. The organic phases were combined, washed once with water, dried, and concentrated. The residue was transferred to a 1 mm thick preparative plate, with DCM/MeOH=10/1, to obtain compound J-043 (75.9 mg). MS: 809.24 [M+H].sup.+.

Example 44 Synthesis of Compound J-044

(6-((5-Bromo-2-((2-methoxy-4-(4-(2-methoxypyrimidin-5-yl)piperazin-1-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0598] ##STR00225##

Step 1: Synthesis of Compound J-044-2

[0599] ##STR00226##

[0600] The synthesis method of compound J-044-2 is the same as that of compound J-043-7, except that the starting compound J-043-6 is replaced by compound J-044-1. MS of compound J-044-2: 426.18 [M+H].sup.+.

Step 2: Synthesis of Compound J-044-3

[0601] ##STR00227##

[0602] The synthesis method of compound J-044-3 is the same as that of compound J-043-8, except that the starting compound J-043-7 is replaced by compound J-044-2. MS of compound J-044-3: 396.21 [M+H].sup.+.

Step 3: Synthesis of Compound J-044

[0603] ##STR00228##

[0604] The synthesis method of compound J-044 is the same as that of compound J-043, except that the starting compound J-043-8 was replaced with compound J-044-3. MS of compound J-044: 810.23 [M+H].sup.+.

Example 45 Synthesis of Compound J-045

(6-((5-Bromo-2-((4-(4-(5-(dimethylamino)pyrazin-2-yl)piperazin-1-yl)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0605] ##STR00229##

Step 1: Synthesis of Compound J-045-2

[0606] ##STR00230##

[0607] The synthesis method of compound J-045-2 is the same as that of compound J-043-7, except that the starting compound J-043-6 is replaced by compound J-045-1. MS of compound J-045-2: 439.21 [M+H].sup.+.

Step 2: Synthesis of Compound J-045-3

[0608] ##STR00231##

[0609] The synthesis method of compound J-045-3 is the same as that of compound J-043-8, except that the starting compound J-043-7 is replaced by compound J-045-2. MS of compound J-045-3: 409.24 [M+H].sup.+.

Step 3: Synthesis of Compound J-045

[0610] ##STR00232##

[0611] The synthesis method of compound J-045 is the same as that of compound J-043, except that the starting compound J-043-8 is replaced with compound J-045-3. MS of compound J-045: 823.26 [M+H].sup.+.

Example 46 Synthesis of Compound J-046

(6-((5-Bromo-2-((2-methoxy-5-(2-methyl-2H-1,2,3-triazol-4-yl)-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0612] ##STR00233##

Step 1: Synthesis of Compound J-046-2

[0613] ##STR00234##

[0614] The synthesis method of compound J-046-1 is the same as that of compound J-043-2, except that the starting compound J-043-1 is replaced by compound 13-3. MS of compound J-046-1: 413.11 [M+H].sup.+.

Step 2: Synthesis of Compound J-046-3

[0615] ##STR00235##

[0616] The synthesis method of compound J-046-3 is the same as that of compound J-043-4, except that the starting compound J-043-2 is replaced by compound J-046-1, and the starting compound J-043-3 is replaced by compound J-046-2. MS of compound J-046-3: 416.23 [M+H].sup.+.

Step 3: Synthesis of Compound J-046-4

[0617] ##STR00236##

[0618] The synthesis method of compound J-046-4 is the same as that of compound J-043-8, except that the starting compound J-043-7 is replaced by compound J-046-3. MS of compound J-046-4: 386.26 [M+H].sup.+.

Step 4: Synthesis of Compound J-046

[0619] ##STR00237##

[0620] The synthesis method of compound J-046 is the same as that of compound J-043, except that the starting compound J-043-8 is replaced by compound J-046-4. MS of compound J-046: 800.28 [M+H].sup.+.

Example 47 Synthesis of Compound J-047

(6-((5-Bromo-2-((2-methoxy-5-(2-methyl-2H-1,2,3-triazol-4-yl)-4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0621] ##STR00238##

Step 1: Synthesis of Compound J-047-2

[0622] ##STR00239##

[0623] The synthesis method of compound J-047-2 is the same as that of compound J-043-2, except that the starting compound J-043-1 is replaced by compound J-047-1. MS of compound J-047-2: 393.05 [M+H].sup.+.

Step 2: Synthesis of Compound J-047-3

[0624] ##STR00240##

[0625] The synthesis method of compound J-047-3 is the same as that of compound J-043-4, except that the starting compound J-043-2 is replaced by compound J-047-2, and the starting compound J-043-3 is replaced by compound J-046-2. MS of compound J-047-3: 396.17 [M+H].sup.+

Step 3: Synthesis of Compound J-047-4

[0626] ##STR00241##

[0627] The synthesis method of compound J-047-4 is the same as that of compound J-043-8, except that the starting compound J-043-7 is replaced by compound J-047-3. MS of compound J-047-4: 366.20 [M+H].sup.+.

Step 4: Synthesis of Compound J-047

[0628] ##STR00242##

[0629] The synthesis method of compound J-047 is the same as that of compound J-043, except that the starting compound J-043-8 is replaced by compound J-047-4. MS of compound J-047: 780.22 [M+H].sup.+.

Example 48 Synthesis of Compound J-048

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(thiazol-2-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0630] ##STR00243##

Step 1: Synthesis of Compound J-048-1

[0631] ##STR00244##

[0632] 2-Bromothiazole (1.00 g, 6.13 mmol, 1.00 eq), tert-butyl piperazine-1-carboxylate (1.71 g, 9.20 mmol, 1.50 eq), K.sub.2CO.sub.3 (2.54 g, 18.39 mml, 3.00 eq) and DMF (20 mL) were mixed and reacted at 100° C. for 72 hours. The reaction solution was cooled to room temperature, poured into 50 mL of water, filtered, washed with 15 mL of water twice, and dried to obtain the product J-048-1 (1.1 g, 4.08 mmol, yield: 66.98%). MS: 270.12 [M+H].sup.+

Step 2: Synthesis of Compound J-048-2

[0633] ##STR00245##

[0634] Compound J-048-1 (1.1 g, 4.08 mmol) was dissolved in DCM (10 mL), followed with adding TFA (3 mL). The mixture reacted at room temperature for 30 min. The reaction solution was spin-dried, added with 20 mL saturated aqueous sodium carbonate solution and 20 mL dichloromethane, separated, dried with anhydrous sodium sulfate, filtered, and spin-dried to obtain compound J-048-2 (570 mg, 3.37 mmol, yield: 82.47%). MS: 170.07 [M+H].sup.+

Step 3: Synthesis of Compound J-048-3

[0635] ##STR00246##

[0636] The synthesis method of compound J-048-3 is the same as that of compound 2-2, except that the starting compound morpholine is replaced by compound J-048-2. MS of compound 12-1: 399.00 [M+H].sup.+

Step 4: Synthesis of Compound J-048-4

[0637] ##STR00247##

[0638] The synthesis method of compound J-048-4 is the same as that of compound 7-2, except that the starting compound 1-6 is replaced by compound J-048-3. MS of compound J-048-4: 401.13 [M+H].sup.+.

Step 5: Synthesis of Compound J-048-5

[0639] ##STR00248##

[0640] The synthesis method of compound J-048-5 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-048-4. MS of compound J-048-5: 371.16 [M+H].sup.+.

Step 6: Synthesis of Compound J-048

[0641] ##STR00249##

[0642] The synthesis method of compound J-048 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-048-5. MS of compound J-048: 785.18 [M+H].sup.+.

Example 49 Synthesis of Compound J-049

(6-((5-Bromo-2-((2-methoxy-4-(4-(6-methoxypyrazin-2-yl)piperazin-1-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0643] ##STR00250##

Step 1: Synthesis of Compound J-049-1

[0644] ##STR00251##

[0645] 2,6-Dichloropyrazine (1.00 g, 6.75 mmol, 1.00 eq), tert-butyl piperazine-1-carboxylate (1.89 g, 10.13 mmol, 1.50 eq), ACN (20 mL) were mixed well and reacted at 80° C. for 2 hours. It was monitored by LCMS until the reaction was completed. The reaction solution was spin-dried, and purified by column chromatography petroleum with petroleum ether:ethyl acetate (3:1) to obtain the product J-049-1 (1.17 g, 3.92 mmol, yield: 57.95%). MS: 299.12 [M+H].sup.+

Step 2: Synthesis of Compound J-049-2

[0646] ##STR00252##

[0647] Compound J-049-1 (1.17 g, 3.92 mmol, 1.00 eq) was dissolved in MeOH (20 mL), followed by adding sodium methoxide (2.11 g, 39.16 mmol, 10.00 eq), and the reaction was refluxed for 4 days. The reaction solution was spin-dried, purified by reversed-phase chromatography with water (containing 0.05% formic acid) as mobile phase A and a mobile phase B (gradient: 0-85% B) for 25 minutes. The resultant was spin-dried to remove the solvent to obtain compound J-049-2 (780 mg, 2.65 mmol, yield: 67.67%). MS: 295.17 [M+H].sup.+

Step 3: Synthesis of Compound J-049-3

[0648] ##STR00253##

[0649] The synthesis method of compound J-049-3 is the same as that of compound J-048-2, except that the starting compound J-048-2 is replaced with compound J-049-2. MS of compound J-049-3: 195.12 [M+H].sup.+

Step 4: Synthesis of Compound J-049-4

[0650] ##STR00254##

[0651] The synthesis method of compound J-048-4 is the same as that of compound 2-2, except that the starting compound morpholine is replaced by compound J-049-3. MS of compound J-049-4: 424.05 [M+H].sup.+.

Step 5: Synthesis of Compound J-049-5

[0652] ##STR00255##

[0653] The synthesis method of compound J-049-5 is the same as that of compound 7-2, except that the starting compound 1-6 is replaced by compound J-049-4. MS of compound J-049-5: 426.18 [M+H].sup.+.

Step 6: Synthesis of Compound J-049-6

[0654] ##STR00256##

[0655] The synthesis method of compound J-049-5 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-049-4. MS of compound J-048-5: 396.21 [M+H].sup.+.

Step 6: Synthesis of Compound J-049

[0656] ##STR00257##

[0657] The synthesis method of compound J-049 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-049-6. MS of compound J-049: 810.23 [M+H].sup.+.

Example 50 Synthesis of Compound J-050

6-(4-(4-((5-Bromo-4-((2-cyclopropyl-5-(dimethylphosphoryl)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-5-methoxy-2-(1-methyl-1H-pyrazol-4-yl)phenyl)piperazin-1-yl)-1-methylpyridin-2(1H)-one

[0658] ##STR00258##

Step 1: Synthesis of Compound J-050-1

[0659] ##STR00259##

[0660] Compound J-043-5 (271 mg, 0.63 mmol, 1.00 eq), 6-bromo-1-methylpyridin-2(1H)-one (141 mg, 0.76 mmol, 1.20 eq), 2-dicyclohexylphosphine-2′,6′-diisopropoxy-1,1′-biphenyl (58 mg, 0.126 mmol, 0.20 eq), RuPhos Pd G3 (52 mg, 0.06 mmol, 0.10 eq) and cesium carbonate (617 mg, 1.89 mmol, 3.00 eq) were mixed well. The reaction was carried out at 100° C. for 8 hours under nitrogen protection. It was monitored by LCMS until the reaction was completed. The reaction solution was spin-dried and purified by column chromatography with DCM:MeOH (15:1) to obtain the product J-050-1 (120 mg, 0.28 mmol, yield: 44%). MS: 425.19 [M+H].sup.+

Step 2: Synthesis of Compound J-050-2

[0661] ##STR00260##

[0662] The synthesis method of compound J-050-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-050-1. MS of compound J-050-2: 395.21 [M+H].sup.+.

Step 3: Synthesis of Compound J-050

[0663] ##STR00261##

[0664] The synthesis method of compound J-050 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-050-2. MS of compound J-049: 809.24 [M+H].sup.+.

Example 51 Synthesis of Compound J-051

(6-((5-Bromo-2-((4-(4-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)piperazin-1-yl)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0665] ##STR00262##

Step 1: Synthesis of Compound J-051-1

[0666] ##STR00263##

[0667] The synthesis of compound J-051-1 is the same as that of J-050-1, except that 6-bromo-1-methylpyridin-2(1H)-one is replaced by 2-(6-bromopyridin-2-yl)propan-2-ol. MS of compound J-051-1: 453.22 [M+H].sup.+

Step 2: Synthesis of Compound J-051-2

[0668] ##STR00264##

[0669] The synthesis method of compound J-051-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-051-1. MS of compound J-051-2: 423.24 [M+H].sup.+.

Step 3: Synthesis of Compound J-051

[0670] ##STR00265##

[0671] The synthesis method of compound J-051 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-051-2. MS of compound J-051: 837.27 [M+H].sup.+.

Example 52 Synthesis of Compound J-052

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-((1-methylpiperidine-4-yl)methyl)amino)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0672] ##STR00266##

Step 1: Synthesis of Compound J-052-1

[0673] ##STR00267##

[0674] The synthesis method of compound J-052-1 is the same as that of compound 2-2, except that morpholine is replaced by (1-methylpiperidin-4-yl)methylamine. MS of compound J-052-1: 358.07 [M+H].sup.+.

Step 2: Synthesis of Compound J-052-2

[0675] ##STR00268##

[0676] The synthesis method of compound J-052-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-052-2. MS of compound J-052-2: 328.09 [M+H].sup.+.

Step 3: Synthesis of Compound J-052

[0677] ##STR00269##

[0678] The synthesis method of compound J-052 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-052-2. MS of compound J-052: 744.25 [M+H].sup.+.

Example 53 Synthesis of Compound J-053

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0679] ##STR00270##

Step 1: Synthesis of Compound J-053-1

[0680] ##STR00271##

[0681] The synthesis method of compound J-053-1 is the same as that of compound 2-2, except that morpholine is replaced by (tetrahydro-2H-pyran-4-yl)methylamine. MS of compound J-053-1: 345.04 [M+H].sup.+.

Step 2: Synthesis of Compound J-053-2

[0682] ##STR00272##

[0683] The synthesis method of compound J-053-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-053-2. MS of compound J-053-2: 315.06 [M+H].sup.+.

Step 3: Synthesis of Compound J-053

[0684] ##STR00273##

[0685] The synthesis method of compound J-053 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-053-2. MS of compound J-053: 731.21 [M+H].sup.+.

Example 54 Synthesis of Compound J-054

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0686] ##STR00274##

Step 1: Synthesis of Compound J-054-1

[0687] ##STR00275##

[0688] The synthesis method of compound J-054-1 is the same as that of compound 2-2, except that morpholine is replaced by 1-methylpiperazine. MS of compound J-054-1: 330.04 [M+H].sup.+

Step 2: Synthesis of Compound J-054-2

[0689] ##STR00276##

[0690] The synthesis method of compound J-054-2 is the same as that of compound 1-11, except that the starting compound 1-10 is replaced by compound J-054-1. MS of compound J-054-2: 300.06 [M+H].sup.+

Step 3: Synthesis of Compound J-054

[0691] ##STR00277##

[0692] The synthesis method of compound J-054 is the same as that of compound J-001, except that the starting compound 1-11 is replaced by compound J-054-2. MS of compound J-054: 716.21 [M+H].sup.+

Example 55 Synthesis of Compound J-055

(6-((5-Bromo-2-((4-(4-cyclopentylpiperazin-1-yl)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0693] ##STR00278##

Step 1: Synthesis of Compound J-055-2

[0694] ##STR00279##

[0695] The synthesis method of compound J-055-2 is the same as that of compound 8-2, except that starting compound 8-1 is replaced by compound 7-1. MS of compound J-055-2: 252.07 [M+H].sup.+.

Step 2: Synthesis of Compound J-055-4

[0696] ##STR00280##

[0697] The synthesis method of compound J-055-4 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-032-1. MS of compound J-055-4: 386.21 [M+H].sup.+.

Step 3: Synthesis of Compound J-055-5

[0698] ##STR00281##

[0699] The synthesis method of compound J-055-5 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-055-4. MS of compound J-055-5: 356.24 [M+H].sup.+.

Step 4: Synthesis of Compound J-055

[0700] ##STR00282##

[0701] The synthesis method of compound J-055 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-055-5. MS of compound J-055: 770.26 [M+H].sup.+.

Example 56 Synthesis of Compound J-056

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyridin-3-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0702] ##STR00283##

Step 1: Synthesis of Compound J-056-2

[0703] ##STR00284##

[0704] The synthesis method of compound J-056-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-056-1. MS of compound J-056-2: 395.18 [M+H].sup.+.

Step 2: Synthesis of Compound J-056-3

[0705] ##STR00285##

[0706] The synthesis method of compound J-056-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-056-2. MS of compound J-056-3: 365.20 [M+H].sup.+.

Step 3: Synthesis of Compound J-056

[0707] ##STR00286##

[0708] The synthesis method of compound J-056 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-056-3. MS of compound J-056: 779.23 [M+H].sup.+.

Example 57 Synthesis of Compound J-057

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0709] ##STR00287##

Step 1: Synthesis of Compound J-057-2

[0710] ##STR00288##

[0711] The synthesis method of compound J-057-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-057-1. MS of compound J-057-2: 395.18 [M+H].sup.+.

Step 2: Synthesis of Compound J-056-3

[0712] ##STR00289##

[0713] The synthesis method of compound J-057-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-057-2. MS of compound J-057-3: 365.20 [M+H].sup.+.

Step 3: Synthesis of Compound J-057

[0714] ##STR00290##

[0715] The synthesis method of compound J-057 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-057-3. MS of compound J-057: 779.23 [M+H].sup.+.

Example 58 Synthesis of Compound J-058

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyrazin-2-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0716] ##STR00291##

Step 1: Synthesis of Compound J-058-2

[0717] ##STR00292##

[0718] The synthesis method of compound J-058-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-058-1. MS of compound J-058-2: 396.17 [M+H].sup.+.

Step 2: Synthesis of Compound J-058-3

[0719] ##STR00293##

[0720] The synthesis method of compound J-058-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-058-2. MS of compound J-058-3: 366.20 [M+H].sup.+.

Step 3: Synthesis of Compound J-058

[0721] ##STR00294##

[0722] The synthesis method of compound J-058 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-058-3. MS of compound J-058: 780.22 [M+H].sup.+.

Example 59 Synthesis of Compound J-059

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinopiperidine-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0723] ##STR00295##

Step 1: Synthesis of Compound J-059-2

[0724] ##STR00296##

[0725] The synthesis method of compound J-059-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-059-1. MS of compound J-059-2: 402.21 [M+H].sup.+.

Step 2: Synthesis of Compound J-059-3

[0726] ##STR00297##

[0727] The synthesis method of compound J-059-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-059-2. MS of compound J-059-3: 372.23 [M+H].sup.+.

Step 3: Synthesis of Compound J-059

[0728] ##STR00298##

[0729] The synthesis method of compound J-059 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-059-3. MS of compound J-059: 786.26 [M+H].sup.+.

Example 60 Synthesis of Compound J-060

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(pyrimidin-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0730] ##STR00299##

Step 1: Synthesis of Compound J-060-2

[0731] ##STR00300##

[0732] The synthesis method of compound J-060-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-060-1. MS of compound J-060-2: 396.17 [M+H].sup.+.

Step 2: Synthesis of Compound J-060-3

[0733] ##STR00301##

[0734] The synthesis method of compound J-060-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-060-2. MS of compound J-060-3: 366.20 [M+H].sup.+.

Step 3: Synthesis of Compound J-060

[0735] ##STR00302##

[0736] The synthesis method of compound J-060 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-060-3. MS of compound J-060: 780.22 [M+H].sup.+.

Example 61 Synthesis of Compound J-061

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(3-methyl-3,6-diazabicyclo[3.1.1]heptyl-6-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-S-yl)dimethylphosphine oxide

[0737] ##STR00303##

Step 1: Synthesis of Compound J-061-2

[0738] ##STR00304##

[0739] The synthesis method of compound J-061-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-061-1. MS of compound J-061-2: 344.16 [M+H].sup.+.

Step 2: Synthesis of Compound J-061-3

[0740] ##STR00305##

[0741] The synthesis method of compound J-061-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-061-2. MS of compound J-061-3: 314.19 [M+H].sup.+.

Step 3: Synthesis of Compound J-061

[0742] ##STR00306##

[0743] The synthesis method of compound J-061 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-061-3. MS of compound J-061: 728.21 [M+H].sup.+.

Example 62 Synthesis of Compound J-062

(6-((5-Bromo-2-((4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0744] ##STR00307##

Step 1: Synthesis of Compound J-062-2

[0745] ##STR00308##

[0746] The synthesis method of compound J-062-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-062-1. MS of compound J-062-2: 334.18 [M+H].sup.+.

Step 2: Synthesis of Compound J-062-3

[0747] ##STR00309##

[0748] The synthesis method of compound J-062-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-062-2. MS of compound J-062-3: 304.21 [M+H].sup.+.

Step 3: Synthesis of Compound J-062

[0749] ##STR00310##

[0750] The synthesis method of compound J-062 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-062-3. MS of compound J-062: 718.23 [M+H].sup.+.

Example 63 Synthesis of Compound J-063

4-(4-(4-((5-bromo-4-((2-cyclopropyl-5-(dimethylphosphoryl)quinolin-6-yl)amino)pyrimidin-2-yl)amino)-5-methoxy-2-(1-methyl-1H-pyrazol-4-yl)phenyl)piperazin-1-yl)pyridin-2(1H)one

[0751] ##STR00311##

Step 1: Synthesis of Compound J-063-2

[0752] ##STR00312##

[0753] The synthesis method of compound J-063-2 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound J-063-1. MS of compound J-063-2: 411.17 [M+H].sup.+.

Step 2: Synthesis of Compound J-063-3

[0754] ##STR00313##

[0755] The synthesis method of compound J-063-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-063-2. MS of compound J-063-3: 381.20 [M+H].sup.+.

Step 3: Synthesis of Compound J-063

[0756] ##STR00314##

[0757] The synthesis method of compound J-063 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-063-3. MS of compound J-063: 795.22 [M+H].sup.+.

Example 64 Synthesis of Compound J-064

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrrol-3-yl)-4-(4-(4-methylpiperazine-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0758] ##STR00315##

Step 1: Synthesis of Compound J-064-2

[0759] ##STR00316##

[0760] The synthesis method of compound J-064-2 is the same as that of compound 8-2, except that starting compound 8-1 is replaced by compound J-064-1. MS of compound J-064-2: 251.08 [M+H].sup.+.

Step 2: Synthesis of Compound J-064-3

[0761] ##STR00317##

[0762] The synthesis method of compound J-064-3 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-064-2, and the starting compound morpholine is replaced by compound 13-3. MS of compound J-064-3: 414.24 [M+H].sup.+.

Step 3: Synthesis of Compound J-064-4

[0763] ##STR00318##

[0764] The synthesis method of compound J-064-4 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-064-3. MS of compound J-064-4: 384.27 [M+H].sup.+.

Step 4: Synthesis of Compound J-064

[0765] ##STR00319##

[0766] The synthesis method of compound J-064 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-064-4. MS of compound J-064: 798.29 [M+H].sup.+.

Example 65 Synthesis of Compound J-065

(2-Cyclopropyl-6-((5-fluoro-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)aminopyrimidin-4-yl)amino)quinolin-5-yl)dimethylphosphine oxide

[0767] ##STR00320##

Step 1: Synthesis of Compound J-065-1

[0768] ##STR00321##

[0769] The synthesis method of compound J-065-1 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-055-2, and the starting compound morpholine is replaced by compound 13-3. MS of compound J-065-1: 415.24 [M+H].sup.+.

Step 2: Synthesis of Compound J-065-2

[0770] ##STR00322##

[0771] The synthesis method of compound J-065-2 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-065-1. MS of compound J-065-2: 385.26 [M+H].sup.+.

Step 3: Synthesis of Compound J-065-3

[0772] ##STR00323##

[0773] The synthesis method of compound J-065-3 is the same as that of compound 1-8, except that the starting compound 5-bromo-2,4-dichloropyrimidine is replaced by compound 5-fluoro-2,4-dichloropyrimidine. MS of J-065-3: 391.08 [M+H].sup.+.

Step 4: Synthesis of Compound J-065

[0774] ##STR00324##

[0775] The synthesis method of compound J-065 is the same as that of compound J-008, except that the starting compound 8-4 is replaced by compound J-065-2, the starting compound 1-8 is replaced by compound J-065-3. MS of compound J-065: 739.37 [M+H].sup.+.

Example 66 Synthesis of Compound J-066

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(1-methylpiperidine-4-yl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0776] ##STR00325##

Step 1: Synthesis of Compound J-066-1

[0777] ##STR00326##

[0778] The synthesis method of compound J-066-1 is the same as that of compound 8-3, except that the raw material compound 8-2 is replaced by compound J-055-2, and the raw material compound morpholine is replaced by compound piperazine. MS of compound J-066-1: 318.15 [M+H].sup.+.

Step 2: Synthesis of Compound J-066-2

[0779] ##STR00327##

[0780] Compound J-066-1 (317 mg, 1.00 mmol), 1-methyl-4-piperidone (339 mg, 3.00 mmol) and HOAc (120 mg, 2 mmol) were added to methanol (10 mL). The mixture was heated to 65° C. under nitrogen protection and stirred for 1 hour. After cooling, sodium cyanoborohydride (126 mg, 2 mmol) was added, and the mixture was stirred for 16 hours at 25° C. under nitrogen protection. It was monitored by TLC until the reaction was completed. The reaction solution was spin-dried and purified by column chromatography (dichloromethane:methanol=20:1). Pale yellow solid J-066-2 (100 mg) was obtained. MS of compound J-066-2: 415.14 [M+H].sup.+.

Step 3: Synthesis of Compound J-066-3

[0781] ##STR00328##

[0782] The synthesis method of compound J-066-3 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-066-2. MS of compound J-066-3: 385.26 [M+H].sup.+.

Step 4: Synthesis of Compound J-066

[0783] ##STR00329##

[0784] The synthesis method of compound J-066 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-066-3. MS of compound J-066: 799.29 [M+H].sup.+.

Example 67 Synthesis of Compound J-067

(6-((5-bromo-2-((5-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0785] ##STR00330##

Step 1: Synthesis of Compound J-067-2

[0786] ##STR00331##

[0787] The synthesis method of compound J-067-2 is the same as that of compound 8-2, except that starting compound 8-1 is replaced by compound J-067-1. MS of compound J-067-2: 288.05 [M+H].sup.+.

Step 2: Synthesis of Compound J-067-3

[0788] ##STR00332##

[0789] The synthesis method of compound J-067-3 is the same as that of compound 8-3, except that the starting compound 8-2 is replaced by compound J-067-2, and the starting compound morpholine is replaced by compound 13-3. MS of compound J-067-3: 451.22 [M+H].sup.+.

Step 3: Synthesis of Compound J-067-4

[0790] ##STR00333##

[0791] The synthesis method of compound J-067-4 is the same as that of compound 8-4, except that starting compound 8-4 is replaced by compound J-067-3. MS of compound J-067-4: 421.24 [M+H].sup.+.

Step 4: Synthesis of Compound J-067

[0792] ##STR00334##

[0793] The synthesis method of compound J-067 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-067-4. MS of compound J-067: 835.27 [M+H].sup.+.

Example 68 Synthesis of Compound J-068

(6-((5-Bromo-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-(4-methylpiperazine-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2-cyclopropylquinolin-5-yl)dimethylphosphine oxide

[0794] ##STR00335##

Step 1: Synthesis of Compound J-068

[0795] ##STR00336##

[0796] The synthesis method of compound J-068 is the same as that of compound J-008, except that starting compound 8-4 is replaced by compound J-065-2. MS of compound J-068: 799.29 [M+H].sup.+.

PHARMACOLOGICAL EXPERIMENTS

Comparable Example 1

[0797] ##STR00337##

[0798] The above compound was prepared according to the synthesis process of the compound 41 in WO2019015655A1.

[0799] Experiment 1 Kinase Inhibition Assay Mobility shift assays were performed to determine inhibitory activity of compounds against EGFR.sup.Δ19del/T790M/C797S, EGFR WT and IGF1R kinases. The enzymatic reaction scheme is as follows:

[0800] 1. Preparing 1*Kinase Buffer as follows:

TABLE-US-00001 Final 1* Kinase Buffer concentration HEPES 50 PH7.5 (mM) Brij-3 5 0.0150% DTT (mM) 2 Mgcl.sub.2, Mncl.sub.2 10 (mM)

[0801] 2. Preparing compound concentration gradient: the initial concentration of the compound tested in the assay was 3,000 nM or 100 nM, which is then diluted to be 100-fold final concentration in 100% DMSO in a 384-source plate. Compounds in 10 concentrations were diluted in a 3-fold gradient with Precision. 250 nL of compound in 100-fold final concentration was transferred to OptiPlate-384F plate by using a dispenser named Echo 550.

[0802] 3. Preparing kinase solution at 2.5-fold the final concentration with 1×kinase buffer.

[0803] 4. Adding 10 μL of kinase solution at 2.5-fold the final concentration to compound wells and positive control wells respectively; and adding 10 μL of 1×kinase buffer to negative control wells.

[0804] 5. Centrifuging the wells at 1,000 rpm for 30 seconds, mixing the reaction plate well by shaking and incubating it at room temperature for 10 minutes.

[0805] 6. Preparing a mixed solution of ATP and kinase substrate at 5-fold/3-fold the final concentration with 1×Kinase buffer, respectively.

[0806] 7. Initiating the reaction by adding 15 μL of the mixed solution of ATP and kinase substrate at 5-fold/3-fold the final concentration.

[0807] 8. Centrifuging the 384-well plate at 1,000 rpm for 30 seconds, mixing the reaction plate well by shaking and incubating it at room temperature for a corresponding time.

[0808] 9. Adding 30 μL of assay stop solution to stop the kinase reaction, and centrifuging the plate at 1,000 rpm for 30 seconds and mixing it well by shaking.

[0809] 10. Reading the conversion rate with Caliper EZ Reader.

[0810] 11. Calculation formula

[00001]$\%\mathrm{Inhibition}=\frac{\mathrm{Conversion}\%\mathrm{\_max}-\mathrm{Conversion}\%\mathrm{\_sample}}{\mathrm{Conversion}\%\mathrm{\_max}-\mathrm{Conversion}\%\mathrm{\_min}}\times 100,$ [0811] wherein, “Conversion % sample” is the conversion rate reading of the sample;

[0812] “Conversion %_min” is the mean value of the negative control wells, representing the conversion rate readings of the well without enzymatic activity; “Conversion %_max” is the mean value of the positive control wells, representing the conversion rate readings of the wells without compound inhibition. [0813] Dose-response curve is plotted with the logarithmic concentration on the X-axis and percent inhibition on the Y-axis. The fitting of the dose-response curve is made with the module “log(inhibitor) vs. response—Variable slope” of the analysis software GraphPad Prism 5, so that the IC50 value of each compound on enzymatic activity is obtained. [0814] The calculation formula is: Y=Bottom+(Top−Bottom)/(1+10{circumflex over ( )}((Log IC50−X)*HillSlope)). The results are expressed as IC.sub.50 values, as shown in Table 1.

TABLE-US-00002 TABLE 1 EGFR Δ19del/ EGFR T790M/C797S WT IGF1R Compound IC.sub.50 (nM) IC.sub.50 (nM) IC.sub.50 (nM) Comparable 0.2 5.1 9.5 example 1 J-001 0.5 51.7 63.6 J-002 0.4 62.8 720.3 J-003 0.5 172.0 189.4 J-004 0.7 283.5 380.3 J-005 0.5 132.2 74.38 J-006 3.5 714 437 J-007 0.2 30.3 41.0 J-009 0.3 14.4 14.76 J-010 0.2 79.0 142 J-011 0.7 45.8 146 J-012 0.2 43.9 279 J-013 0.4 11.4 28.2 J-014 0.19 4.7 58 J-015 0.29 12.1 12.1 J-016 0.30 4.6 16.8 J-017 0.3 18.4 246.4 J-018 0.3 7.3 178 J-019 0.33 16.0 222.0 J-020 0.72 21 107 J-021 0.3 19.3 293.4 J-022 0.3 20.2 195 J-023 0.28 17 27 J-024 0.5 113.7 139.6 J-025 43 2310 >3000 J-026 36.0 >3000 >3000 J-027 0.3 11.1 61.6 J-028 0.14 19 116 J-029 0.22 41.29 58.05 J-031 0.5 64 103 J-032 1.0 121 170 J-034 0.12 23 298 J-037 1.0 138 210 J-038 0.9 171 586 J-039 0.5 33.5 21.5 J-040 6.0 550 1162 J-041 0.2 11.5 25 J-042 0.3 21.1 107

[0815] It can be seen from Table 1 that the compounds of the present invention have a strong inhibitory effect on the EGFR.sup.Δ19del/T790M/C797S mutant kinase, but have weaker inhibitory effects on the wild-type kinase EGFR WT and IGF1R in the insulin receptor family. However, the compound of Comparative example 1 not only has a strong inhibitory effect on the EGFR.sup.Δ19del/T790M/C797S mutant kinase, but also has a strong inhibitory activity on EGFR WT and IGF1R. This shows that the compounds of the present invention have better selectivity relative to the compound of Comparative Example 1.

[0816] Experiment 2 Cell Proliferation Experiment

[0817] 1. Cell Culture

[0818] Cell Line:

[0819] Suspension cells: Ba/F3 cells with stable overexpression of Δ19del/T790M/C797S mutant gene, named Ba/F3-Δ19del/T790M/C797S; Ba/F3 cells with overexpression of EGFR WT, named Ba/F3 EGFR WT.

[0820] Adherent cells: human epidermal cancer cells A431 carrying EGFR WT.

[0821] A. Culture Medium

[0822] RPMI 1640 with 10% FBS and 1% Penicillin-Streptomycin, or DMEM with 10% FBS and 1% Penicillin-Streptomycin.

[0823] B. Cell Thawing

[0824] a) Preheating a medium in a 37° C. water bath.

[0825] b) Taking out the cryovial tube from the liquid nitrogen tank and placing it immediately in a 37° C. water bath and making it melted completely within 1 minute.

[0826] c) Transferring the cell suspension to a 15 mL centrifuge tube containing 8 mL of medium and centrifuging it at 1,000 rpm for 5 minutes.

[0827] d) Discarding the supernatant and resuspending the cells in 1 mL medium, followed by transferring to a 75 cm.sup.3 culture flask containing 15 mL medium, adding with an appropriate volume of medium, and cultivating in an incubator with 5% CO.sub.2 at 37° C.

[0828] C. Cell Passaging

[0829] a) Preheating a medium in a 37° C. water bath.

[0830] b) Collecting cells: for suspended cells, directly collecting the cells into a 15 mL centrifuge tube; for adherent cells, washing the cells with PBS, followed by adding an appropriate trypsin for digestion, adding medium, pipetting and transferring the cells to a 15 mL centrifuge tube. Subsequently, centrifuging the cells at 1,000 rpm for 5 minutes, discarding the supernatant, resuspending the cells, and passaging the cells according to an appropriate ratio in an incubator with 5% CO.sub.2 at 37° C.

[0831] 2. Compound Preparation

[0832] a) Diluting compounds being tested (20 mM stock solutions), as an initial concentration, to 10 mM with 100% DMSO, followed by diluting compounds serially in a 3-fold gradient such that each compound is diluted into 12 concentrations (Cat #P-05525, Labcyte).

[0833] b) Diluting the above compound solutions for 100-fold with culture medium to prepare 10-fold working solution.

[0834] 3. Cell Seeding in 96-Well Plate

[0835] a) Centrifuging cells in logarithmic phase at 1,000 rpm for 5 minutes, discarding the supernatant, and resuspending the cells in medium and counting.

[0836] b) Seeding cells into 96-well cell culture plate at a density of 2000 or 3000 cells/well, with 135 μL/well.

[0837] 4. Compound Handling

[0838] a) Adding the compound prepared in step 2 to the cell plate at 15 μL per well, resulting in a final maximum concentration of 10000 nM or 1111 nM. The compounds is diluted serially in a 3-fold gradient such that each compound is diluted into 9 concentrations, wherein the final concentration of DMSO is 0.1%. Blank control wells are added with medium (0.1% DMSO).

[0839] b) Re-incubating the cells in an incubator for 72 hours. 5. Detection

[0840] a) Adding 50 μL of CTG reagent (CellTiter Glo kit, promega, Cat #G7573) to the 96-well cell culture plate.

[0841] b) Shaking the plate for 2 minutes and reacting at room temperature for 10 minutes.

[0842] c) Reading the luminescence signal value (Lum) using PerkinElmer reader.

[0843] 6. Experimental Data Processing

[0844] The cell survival inhibition rate of each well was calculated. The data was analyzed by GraphPad Prism 6.0 software. The dose-response curve was obtained by fitting the data with a nonlinear regression equation. The IC50 of each compound was calculated as follows:

Cell survival inhibition rate (%)=(1−(Lum.sub.compound tested−Lum.sub.medium control)/(Lum.sub.cell control−Lum.sub.medium control))×100%

Y=Min+(Max−Min)/(1+10{circumflex over ( )}((Log IC.sub.50−X)*Slope));

[0845] X: logarithm of compound concentration. Y: cell survival inhibition rate.

[0846] The results of the cell proliferation assay were expressed as IC.sub.50, as shown in Table 2.

TABLE-US-00003 TABLE 2 Ba/F3/EGFR Δ19del/ BaF3 EGFR T790M/C797S WT A431 Compound IC.sub.50 (nM) IC.sub.50 (nM) IC.sub.50 (nM) Comparable 9 39.9 245 example 1 J-001 26.5 395.6 1352 J-003 25.7 646 3041 J-005 27 698 6139 J-007 6.0 146.6 1030 J-009 16.3 168 383.5 J-010 11.5 187.3 969.3 J-011 4.7 190.1 1157 J-012 3.4 129.7 830.2 J-013 15.3 87 307.7 J-014 6.0 108 514 J-015 15.8 388 678 J-016 5.1 132 379 J-018 1.9 160 1501 J-020 2.2 144 982.7 J-021 11.7 238 1135 J-022 6.8 151 1128 J-023 6.4 117 877 J-024 26.7 373 1377 J-027 1.4 52 9010 J-028 20.8 155 842 J-029 12.09 98.52 203.6 J-033 12.9 611 >10000 J-034 5.8 189.2 440.5 J-039 12 256 1109 J-041 28.4 354 228 J-042 8.18 296 373 J-043 10.9 67.6 896 J-044 1.0 25.2 432 J-045 13.5 130 710 J-046 1.2 117 475 J-047 0.5 21 176 J-048 7.6 52 1100 J-049 8.5 109 2295 J-050 1.8 42.2 861 J-052 2.6 123 279 J-053 3.9 54 753 J-054 0.8 15.8 143 J-055 12.4 79 1174 J-056 0.8 38 1098 J-057 3.0 54 328 J-058 5.8 117 649 J-059 0.4 10.6 264 J-060 2.3 54 366 J-062 1.4 46.2 157 J-064 1.1 14.6 128 J-065 13 73 425 J-066 4.4 77.9 259 J-067 2.4 37.3 632 J-068 1.0 33.2 201

[0847] It can be seen from Table 2 that the compounds of the present invention have a strong inhibitory effect on the proliferation of Ba/F3-Δ19del/T790M/C797S cells, and have a weak or even have no obvious inhibitory effect on the wild-type EGFR cells Ba/F3 EGFR WT and A431. However, the compound of Comparative example 1 not only has a strong inhibitory effect on the proliferation of Ba/F3-Δ19del/T790M/C797S cells, but also has a strong inhibitory effect on BaF3 EGFR WT, and also has a certain inhibitory effect on A431. This shows that the compound of the present invention has better selectivity relative to the compound of Comparative Example 1.

[0848] Experiment 3 In Vivo Experiment

[0849] 1. In Vivo Efficacy Experiments

[0850] In vivo efficacy experiments were performed on Ba/F3-Δ19del/T790M/C797S-derived xenograft (CDX) BALB/c nude mice. Female BALB/c nude mice of 6-8 weeks old with a body weight of about 18-22 g were randomly grouped, with 6 mice in each group. They were fed in an SPF environment, with each cage individually ventilated (6 mice per cage). All cages, bedding and water were disinfected prior to use. Mice were purchased from Viton Lever and were allowed to acclimate in the laboratory. Each mouse was subcutaneously inoculated with 0.1 mL cells (5×10.sup.6 cells, the volume ratio of matrigel to cell was 1:1) on the right upper limb. When the tumor volume was about 150 mm.sup.3, the grouped mice were separately administered with compound J-022 (10 mg/kg, 100 mg/kg, 150 mg/kg) orally QD for 15 consecutive days. Tumor diameters were measured with vernier calipers twice a week. The volume of tumor is calculated as: V=0.5a×b.sup.2, wherein a and b represent the long diameter and short diameter of the tumor, respectively. The tumor growth inhibition rate TGI (%) was calculated to evaluate the tumor inhibitory effect of the compounds. TGI (%) was calculated with the following formula: TGI (%)=(1−(the average tumor volume of the compound treatment group at the end of the administration−the average tumor volume of the compound treatment group at the beginning of the administration)/(the average tumor volume of the solvent control group at the end of treatment−the average tumor volume of the solvent control group at the beginning of treatment))×100%. The experimental results are shown in Table 3.

TABLE-US-00004 TABLE 3 Dosage Compound (mg/kg/ Tumor volume (mm.sup.3) 15 day tested day) 0 day 3 day 7 day 10 day 15 day TGI % Solvent N/A 150 254 494 1215 3330 NA control Compound 10 152 183 321 747 1650  53% J-022 100 151 99 59 0 0 105% 150 152 102 4 0 0 105%

[0851] It can be seen from Table 3 that when compound J-022 was administered for 15 consecutive days with 10 mg/kg/day, the corresponding TGI was 53%. When it was administered 100 mg/kg/day or 150 mg/kg/day, tumor completely regressed.

[0852] Moreover, the data of Comparative example 1 (in the patent WO2019/015655A1) was cited in Table 4, and the TGI of each administration group was calculated. Nonlinear fitting was performed according to the administrating dosage and the tumor growth inhibition rate TGI (%) corresponding to each dosage using GraphPad Prism 8. The fitting formula is as follows and its ED.sub.50 (half effective dose) was calculated: Y=Bottom+(Top-Bottom)/(1+10{circumflex over ( )}((Log ED50−X)*HillSlope)). The result is shown in FIG. 1.

TABLE-US-00005 TABLE 4 TGI (%) calculated with reference to the tumor volume data at 0 day and 13 day in WO2019/015655A1 Tumor volume Compound Dosage (mm.sup.3) 13 day tested (mg/kg/day) 0 day 13 day TGI % Solvent control N/A 84 1048 NA Control  5 84 814  24% example 1 15 84 211  87% 45 84 0 109%

[0853] TGI was calculated according to the administration dosage and tumor growth volume of Comparative example 1. Nonlinear fitting was performed on the administration dosage and corresponding TGI (%). It was calculated that when the TGI (%) of Comparative example 1 was 50%, the corresponding dosage (the half effective dose ED.sub.50) was 8.7 mg/kg/day. It can be seen that the half effective dose of compound J-022, which is 10 mg/kg/day, is equivalent to that of Comparative example 1.

[0854] 2. In Vivo Safety Experiments

[0855] The safety evaluation of the drug was carried out in BALB/c nude mice. Female BALB/c nude mice of 6-8 weeks old with a body weight of about 17-21 g were randomly grouped, with 5 mice in each group. They were fed in an SPF environment, and each cage was individually ventilated (5 mice per cage). All cages, bedding and water were disinfected prior to use. Mice were purchased from Viton Lever and were allowed to acclimate in the laboratory. Mice were administered orally QD. Comparative example 1 (75 mg/kg/day) and compound J-022 (75 mg/kg/day, 100 mg/kg/day, 150 mg/kg/day) were administered for 7 consecutive days (the first day of administration is the 0th day). The body weight was measured 3 times a week and the data is shown in Table 5. The changes in the body weight of mice were observed, so as to judge the safety and tolerance of the compounds.

TABLE-US-00006 TABLE 5 Compound Dosage Body weight of mouse (g) tested (mg/kg /day) 0 days 2 days 4 days 6 days Solvent control N/A 18/7 18.8 19.3 19.6 Control 75 18.7 15.9 13.8 all dead example1 Compound 75 18.7 18.9 19.2 19.4 J-022 100 18.7 18.6 19.0 19.2 150 18.7 18.3 18.5 18.4

[0856] It can be seen from Table 5 that, compared with the solvent control group, after oral administration of 75 mg/kg/day of Comparative example 1 to mice, the body weight of mice began to decrease on the 2nd day, decreased significantly on the 4th day, and all the 5 mice died on the 6th day. On the contrary, for the mice orally administered the compound of the present invention at 75 mg/kg/day or 100 mg/kg/day, the changes in the body weight on the 2nd, 4th, and 6th days were the same as those in the solvent control group. For mice orally administered the compound of the present invention at 150 mg/kg/day, the body weight did not decrease significantly. It shows that the compound of the present invention has higher safety and less toxicity than the compound of Comparative example 1.

[0857] In addition, when the Comparative example 1 was administered 75 mg/kg/day for 7 consecutive days, all mice died of intolerance. From FIG. 1 and Table 4, it can be seen that the dose when the TGI of Comparative example 1 reaching 50% (ED50) is 8.7 mg/kg/day. Assuming that the dose corresponding to 50% TGI is the effective dose, the window from the effective dose to the intolerance dose of Comparative example 1 is less than 8.6 times. However, compound J-022 was continuously administered at 150 mg/kg/day for 7 days, and there was no significant change in the body weight of mice, indicating that it is tolerable at this dose. It can be seen from Table 3 that the TGI of compound J-022 at 10 mg/kg/day is 53%, which indicates that compound J-022 has a window greater than 15 times from the effective dose to the intolerance dose. In conclusion, the window from the effective dose to the intolerance dose of compound J-022 was greater than that of the Comparative example 1.