Composition for scar remodeling

Abstract

A composition intended for the remodelling treatment of a scar, by means of topical application, in particular, as a massage adjuvant. The composition takes the form of a microemulsion, preferably with a gel texture, containing a lipophilic compound, a wound healing agent, a humectant and an emulsifying agent, as well as a small amount of water.

Claims

1. A scar treatment composition, applicable topically, comprising a lipophilic phase and an aqueous phase in the form of a microemulsion with one of the phases being dispersed as fine droplets in the other phase, said composition containing: one or more lipophilic compounds in a total amount of greater than or equal to 40% by weight relative to the total weight of the composition; a wound-healing agent; a humectant; an emulsifier; and water in a total amount between 1% and 10% by weight relative to the total weight of the composition.

2. The composition according to claim 1, having a dynamic viscosity at 22° C. of greater than or equal to 8000 mPa.s.

3. The composition according to claim 1, in the form of a microemulsion of oil-in-water type.

4. The composition according to claim 1, wherein the wound-healing agent contains hyaluronic acid or a salt thereof.

5. The composition according to claim 4, wherein the wound- healing agent contains a combination comprising hyaluronic acid or a salt thereof, L-alanyl-L-glutamine and an oat extract.

6. The composition according to claim 1, wherein the total amount of wound-healing agent(s) in the composition is between 0.01% and 3% by weight relative to the total weight of the composition.

7. The composition according to claim 1, containing glycerol as a heating agent, which produces heat when it is applied to the skin surface.

8. The composition according to claim 1, wherein said humectant is a polyol.

9. The composition according to claim 8, wherein said humectant is glycerol.

10. The composition according to claim 9, wherein the total amount of glycerol is between 10% and 50% by weight relative to the total weight of the composition.

11. The composition according to claim 1, wherein the one or more lipophilic compounds are selected from the group consisting of triglycerides and mixtures of triglycerides.

12. The composition according to claim 1, wherein the emulsifier contains at least one compound selected from the group consisting of: sugar esters; esters of fatty acids and polyglycerol; or any one of the mixtures thereof.

13. The composition according to claim 1, wherein the emulsifier contains, as a mixture: a sugar ester; a polyol; at least one lipophilic compound selected from the group consisting of triglycerides and mixtures of triglycerides.

14. The composition according to claim 1, wherein the total amount of emulsifier(s) in the composition is between 1% and 30% by weight relative to the total weight of the composition.

15. The composition according to claim 1, containing an antioxidant.

16. The composition according to claim 1, which is free of preservative.

17. A method for treating a scar, comprising a step of topically applying a composition according to claim 1, to said scar.

18. The method according to claim 17, comprising, after: topically applying the composition to the surface of the scar, a step of massaging of the scar.

19. The method according to claim 17, implemented for a period of two months to two years starting from complete re-epidermization of a lesion responsible for the scar.

20. The composition according to claim 1, wherein the emulsifier contains, as a mixture: a sucrose ester; glycerol; and capric and/or caprylic acid triglycerides.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) The characteristics and advantages of the disclosed embodiment will emerge more clearly in the light of the examples of implementation below, which are provided simply by way of illustration and which are in no way limiting of the disclosed embodiment, with the support of FIG. 1, which illustrates the flow capacity a/ of a composition according to the disclosed embodiment, and b/ of a prior art oil composition, 1 g of each of the compositions having been deposited respectively on a watch glass, the latter being inclined so as to cause the composition to flow at its surface.

DETAILED DESCRIPTION

Example 1

(2) A composition in accordance with the presently disclosed embodiment is prepared from the ingredients indicated in Table 1 below. For each of these ingredients, the amount is indicated as percentage by weight, relative to the total weight of the composition, it being understood that the amount of water in the composition is at least 1%, and does not exceed 10%, by weight relative to the total weight of the composition.

(3) TABLE-US-00001 TABLE 1 Composition according to the disclosed embodiment Ingredient Amount (% w/w) Sucragel ® CF 10-30 Caprylic/capric triglycerides 40-60 Olive oil 1-6 Glycerol 10-40 Sodium hyaluronate 0.01-1   Oat seedling extract 0.01-1   L-Alanyl-L-glutamine 0.01-1   Vitamin E 0.1-1.5 Water qs

(4) The dynamic viscosity of this composition in the initial state is measured by means of a Lamy Rheology RM180 Rheomat rheometer (measuring spindle: size 3; rotational speed: 7.61 s.sup.−1; temperature: 22° C.).

(5) This dynamic viscosity is between 16 000 and 22 000 mPa.Math.s.

(6) In order to evaluate the flow capacity of this composition, 1 g of composition is deposited on a watch glass, and the watch glass is inclined so as to cause the composition to flow on its surface. By way of comparative example, the same experiment is carried out with the oil mixture sold under the name Bi-Oil by the Omega Pharma laboratories. The results obtained are shown in FIG. 1. As can be seen, while the Bi-Oil composition flows along the surface of the glass (in b/ in the FIGURE), the composition according to the disclosed embodiment does not flow at all (in a/ in the FIGURE), for the same inclination of the glass.

(7) This composition according to the disclosed embodiment, which in the initial state is in the form of an oily gel, is applied to the scar after total closure of the lesion which is responsible for said scar, preferably at a rate of once or twice a day. To this effect, circular movements are first of all carried out for a few minutes, followed by palpating-rolling massage.

(8) During the first phase, the gel form prepares the skin for the massage by activating the microcirculation.

(9) During the second phase, the palpating-rolling massage softens the skin, acts on the collagen and elastin fibres and thus contributes to optimal remodelling of the skin.

(10) Such a treatment provides long-lasting soothing of the sensations of tautness, and promotes epidermal remodelling. After a few weeks of treatment, scar marks and stretch marks are less visible.

(11) By way of comparative example, a similar composition is prepared, but in which the Sucragel® CF is replaced as emulsifier with a mixture of cetearyl glucoside and of cetearyl alcohol proposed by document WO 2014/167039 in the example thereof which appears on page 12. This mixture of compounds does not make it possible to form a microemulsion, nor even a stable emulsion, so that the composition obtained does not prove to be in any way suitable for prolonged massaging of the skin surface.

Example 2

(12) A composition in accordance with the presently disclosed embodiment is prepared from the ingredients indicated in Table 2 below. For each of these ingredients, the amount is indicated as percentage by weight, relative to the total weight of the composition, it being understood that the amount of water in the composition is at least 1%, and does not exceed 10%, by weight relative to the total weight of the composition.

(13) TABLE-US-00002 TABLE 2 Composition according to the disclosed embodiment Ingredient Amount (% w/w) Polyglyceryl-10 Myristate  1-15 Caprylic/capric triglycerides 40-70 Olive oil 1-6 Glycerol 10-50 Sodium hyaluronate 0.01-1   Oat seedling extract 0.01-1   L-Alanyl-L-glutamine 0.01-1   Vitamin E 0.1-1.5 Water qs

(14) This composition is in the form of an oily gel. Its viscosity in the initial state, measured as indicated above in Example 1, at 22° C., is between 10 000 and 16 000 mPa.Math.s.

(15) This composition is applied to the scar under the same conditions as those described above with reference to Example 1.

(16) Here again, the treatment provides long-lasting soothing of the sensations of tautness and promotes remodelling of the epidermis. After a few weeks of treatment, scar marks and stretch marks are also less visible.