METHODS OF MEASURING FACTOR D ACTIVITY AND POTENCY OF FACTOR D INHIBITORS

Abstract

The invention relates to methods of measuring the activity of Factor D, the key driver in the activation of the alternative complement pathway, methods of determining the potency of Factor D inhibitors, and methods of screening for Factor D inhibitors.

Claims

1. A method of measuring the activity of Factor D in a sample derived from a subject, comprising performing a proximity-based measurement assay, wherein the proximity-based measurement assay measures the cleavage of Factor B.

2. The method of claim 1, comprising: (a) adding to the sample an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety, wherein one of the moieties is a donor, and the other moiety is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor Ba and Factor Bb are in proximity; and (b) measuring the value of the proximity signal from the sample; wherein the activity of Factor D in the sample is negatively correlated with the value of the proximity signal.

3. The method of claim 2, further comprising: (c) adding to a control sample the anti-Factor Ba antibody labeled with the first moiety and the anti-Factor Bb antibody labeled with the second moiety; and (d) measuring the value of the proximity signal from the control sample; wherein a greater value of the proximity signal from the sample relative to the control sample indicates a lower activity of Factor D in the sample relative to the control sample.

4. (canceled)

5. The method of claim 1, comprising: (a) adding to the sample an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety, wherein one of the moieties is a donor, and the other moiety is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor C3b and Factor Ba are in proximity; and (b) measuring the value of the proximity signal from the sample; wherein the activity of Factor D in the sample is negatively correlated with the value of the proximity signal.

6.-10. (canceled)

11. A method of determining the potency of a Factor D inhibitor in inhibiting Factor D activity, comprising performing a proximity-based measurement assay, wherein the proximity-based measurement assay measures the cleavage of Factor B.

12. The method of claim 11, comprising: (a) mixing the Factor D inhibitor with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other moiety is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor Ba and Factor Bb are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the potency of the Factor D inhibitor is positively correlated with the value of the proximity signal.

13.-14. (canceled)

15. The method of claim 11, comprising: (a) mixing the Factor D inhibitor with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other moiety is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor C3b and Factor Ba are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the potency of the Factor D inhibitor is positively correlated with the value of the proximity signal.

16.-19. (canceled)

20. The method of claim 11, wherein the Factor D inhibitor is an antibody or an antigen-binding fragment thereof.

21. The method of claim 20, wherein the antibody is lampalizumab.

22. The method of claim 20, wherein the antibody comprises one, two, three, four, five or six of the following HVRs: (i) an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1; (ii) an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4; (iii) an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO: 7, or SEQ ID NO: 8; (iv) an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, or SEQ ID NO: 17; (v) an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18; or (vi) an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19 or SEQ ID NO: 20.

23. The method of claim 20, wherein the antibody comprises one, two, three, four, five or six of the following HVRs: (i) an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85; (ii) an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88, SEQ ID NO: 89, SEQ ID NO: 90, SEQ ID NO: 91, SEQ ID NO: 92, SEQ ID NO: 93, or SEQ ID NO: 94; (iii) an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95; (iv) an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96; (v) an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, SEQ ID NO: 98, or SEQ ID NO: 99; or (vi) an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100 or SEQ ID NO: 101.

24. A method of screening for a Factor D inhibitor from a plurality of Factor D inhibitor candidates, comprising performing a proximity-based measurement assay, wherein the proximity-based measurement assay measures the cleavage of Factor B.

25. The method of claim 24, comprising: (a) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor Ba and Factor Bb are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the degree of Factor D activity inhibition by a Factor D candidate is positively correlated with the value of the proximity signal.

26.-27. (canceled)

28. The method of claim 24, comprising: (a) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor C3b and Factor Ba are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the degree of Factor D activity inhibition by a Factor D candidate is positively correlated with the value of the proximity signal.

29.-38. (canceled)

39. A kit comprising an anti-Factor Ba antibody, an anti-Factor Bb antibody, a first moiety and a second moiety, wherein: (a) the anti-Factor Ba antibody is labeled or can be labeled with the first moiety, the anti-Factor Bb antibody is labeled or can be labeled with the second moiety; and (b) one of the moieties is a donor, and the other moiety is an acceptor.

40. The kit of claim 39, wherein the anti-Factor Ba antibody and/or the anti-Factor Bb antibody is immobilized on a solid surface.

41. A kit comprising an anti-Factor C3b antibody, an anti-Factor Ba antibody, a first moiety and a second moiety, wherein: (a) the anti-Factor C3b antibody is labeled or can be labeled with the first moiety, the anti-Factor Ba antibody is labeled or can be labeled with the second moiety; and (b) one of the moieties is a donor, and the other moiety is an acceptor.

42. The kit of claim 41, wherein the anti-Factor C3b antibody and/or the anti-Factor Ba antibody is immobilized on a solid surface.

43.-51. (canceled)

Description

4. BRIEF DESCRIPTION OF FIGURES

[0081] FIG. 1 depicts the assay schematic for the factor D TR-FRET (Time Resolved-FRET) assay.

[0082] FIG. 2 depicts the co-titration of Streptavidin-Alexa-Fluor 647 and anti-Factor Ba-Europium. Varying concentrations of the Streptavidin-Alexa-Fluor 647 and anti-Factor Ba-Europium were analyzed with fixed concentrations of the other reagents and then the assay was performed as described in Section 6.1, in order to optimize the signal of the TR-FRET assay.

[0083] FIG. 3 depicts the TR-FRET ratios with different incubation times of the enzymatic reaction of the lampalizumab/Factor D/Factor B/Factor C3b mixture. Note that the activity of Factor D was greatly diminished when the detection reagents were added prior to initiation of the enzymatic reaction (t=0) and increased with increasing time.

[0084] FIG. 4 depicts the TR-FRET ratios with different incubation times of the detection reagents (i.e., the mixture of anti-Factor Bb, anti-Factor Ba-Europium and Streptavidin-Alexa Fluor 647).

[0085] FIGS. 5A and 5B show that both the TR-FRET and the AlphaScreen detection technologies generated good signal and dynamic range.

5. DETAILED DESCRIPTION

[0086] The present invention provides methods of measuring Factor D activity comprising performing a proximity-based measurement assay, methods of determining the potency of Factor D inhibitors comprising performing a proximity-based measurement assay, and methods of screening for Factor D inhibitors comprising measuring Factor B cleaving using a proximity-based measurement assay. The methods are simple, fast, homogeneous and adaptable to high-throughput assays, and are based in part on the inventors' development and characterization of an assay that measures the ability of Factor D inhibitors (including lampalizumab (an anti-Factor D antibody)) to inhibit the enzymatic activity of Factor D (see Section 6). To more precisely measure Factor D activity or the potency of Factor D inhibitors, a quencher can be added to terminate the enzymatic cleavage of Factor B by Factor D before measuring. Luckily, the inventors have discovered that when both anti-Factor Ba and anti-Factor Bb are used as detection reagents, they quench the Factor D activity in the assay, therefore obviating the need to add another quencher.

[0087] 5.1. Proximity-Based Measurement Assays

[0088] The proximity-based measurement assay performed according to the methods described herein can utilize any proximity-based technology known in the art for measuring the binding of a protein pair. Such assays utilize a proximity signal that is generated by an acceptor and/or a donor when the acceptor and the donor (each of which is part of, binds to, or is attached to one member of the protein pair) are brought to close proximity. Thus, the value of the proximity signal is sensitive to the distance between the acceptor and the donor. In some embodiments, the proximity signal is a signal generated by the acceptor and the donor which indicates that the acceptor and the donor (and thus the protein pair) are in proximity. In some embodiments, the proximity signal is a signal generated by the acceptor which indicates that the acceptor and the donor (and thus the protein pair) are in proximity. In some embodiments, the proximity signal is a signal generated by the donor which indicates that the acceptor and the donor (and thus the protein pair) are in proximity.

[0089] The donor/acceptor pair thus can be any pair of molecules that can generate a proximity signal whose value is sensitive to their distance. The donor and/or the acceptor may be attached to the molecule(s) of interest (i.e., member(s) of the protein pair) by a protein (e.g., an antibody or antigen-binding fragment thereof), peptide, peptide mimetic, aptamer, nucleotide (e.g., DNA, RNA, shRNA, miRNA, siRNA, antisense DNA), or any other molecule that binds to the member of the protein pair, or by direct chemical labeling. The degree of proximity between the donor and the acceptor that is required to elicit a proximity signal is dependent on the specific technology employed. Non-limiting exemplary proximity-based technologies for measuring the binding of a protein pair include Fluorescence Resonance Energy Transfer (FRET) and other FRET-based methods such as Time Resolved-FRET (TR-FRET), AlphaScreen, AlphaLISA, and PCR-based proximity ligation assays (see for example, Morrison, 1988, Anal Biochem 174:101-120; Ullman et al., 1994, Proc Natl Acad Sci USA 91: 5426-5430; Ullman et al., 1996, Clin Chem 42:1518-1526; Glickman et al., 2002, Journal of Biomolecular Screening 7:3-10; Bielefeld-Sevigny, 2009, Assay Drug Dev Technol 7:90-92; and Gullberg et al., 2004, Proc Natl Acad Sci USA 101: 8420-8424).

[0090] Fluorescence resonance energy transfer (FRET) is the transfer of energy between a light-sensitive donor and a light-sensitive acceptor. The donor, after being excited by a light source, may transfer energy to the acceptor. The transfer of energy leads to a reduction in the donor's fluorescence emission intensity and an increase in the acceptor's fluorescence emission intensity. The efficiency of this energy transfer is inversely proportional to the sixth power of the distance between donor and acceptor, making FRET extremely sensitive to small changes in distance, and making FRET useful in determining if the donor and the acceptor are within a certain distance of each other. When the proximity-based technology is Fluorescence Resonance Energy Transfer (FRET), the proximity signal can be the ratio between the FRET acceptor's fluorescence emission intensity and the FRET donor's fluorescence emission intensity that is higher than a baseline level (e.g., about 2-fold, 5-fold, 10-fold, 20-fold, 50-fold, 100-fold higher or more). A baseline level here is the ratio between the FRET acceptor's fluorescence emission intensity and the FRET donor's fluorescence emission intensity when the FRET acceptor and the FRET donor are apart (e.g., more than 10 nm, 20 nm, 50 nm, 100 nm, or 200 nm apart).

[0091] TR-FRET is a FRET technology that has introduced a time delay between the excitation of the donor and the fluorescence measurement to reduce or clear the non-specific interfering short-lived emission signals from the background (for example, buffers and cell lysates). The emission signals from the donor and the acceptor, however, are long-lived and will not be affected.

[0092] A pair of light-sensitive donor and acceptor molecules that interact in such a manner that FRET occurs is often referred to as a FRET pair, and is known to those skilled in the art. The mechanism of FRET-pair interaction requires that the excitation spectrum of the acceptor overlaps the emission spectrum of the donor (see, Stryer, 1978, Ann Rev Biochem 47:819-846; Cantor and Schimmel, 1980, Biophysical Chemistry Part II: Techniques for the Study of Biological Structure And Function, pages 448-455, San Francisco, Calif.: W. H. Freeman and Co.; and Selvin, 1995, Methods in Enzymology 246:300-335). The efficiency of FRET interaction is linearly proportional to this overlap (Haugland et al., 1969, Proc Natl Acad Sci USA 63:24-30). FRET pairs have been chosen on this basis.

[0093] Any of a number of FRET-pair combinations can be selected for use in the present invention (see for example, Pesce et al, eds, 1971, Fluorescence Spectroscopy, New York, N.Y.: Marcel Dekker; White et al., 1970, Fluorescence Analysis: A practical Approach, New York, N.Y.: Marcel Dekker; and Haugland, 1996, Handbook of Fluorescent Probes and Research Chemicals, 6th Ed, Eugene, Oreg.: Molecular Probes, Inc.). In general, a preferred donor is selected that has an emission spectrum that substantially overlaps the acceptor's excitation spectrum. In such applications the use of intense laser light, high-powered LED, or xenon flash lamp can serve as an effective means to excite the donor. The acceptor has a substantial overlap of its excitation spectrum with the emission spectrum of the donor. In addition, the wavelength maximum of the emission spectrum of the acceptor is preferably at least 10 nm greater than the wavelength maximum of the excitation spectrum of the donor. The emission spectrum of the acceptor is typically in the red portion of the visible spectrum, although, it is believed that acceptors having emission at longer wavelengths in the infrared region of the spectrum can be used. In some embodiments, the donor comprises Europium, the acceptor comprises Alexa 647, and the light source has a wavelength of about 340 nm.

[0094] In order to obtain FRET between the donor and the acceptor, the two have to be in spatial proximity with each other. Thus, in certain embodiments, the assay components are labeled such that the donor and the acceptor can be about 0.1 nm, 0.5 nm, 1 nm, 5 nm, or 10 nm apart from each other, or less than about 10 nm to allow FRET to occur.

[0095] AlphaScreen and AlphaLISA are bead-based technologies, and the assays are conducted in a microplate format. The donor and the acceptor are in the form of beads. Donor beads contain a photosensitizer, phthalocyanine, which converts ambient oxygen to an excited and reactive form of O.sub.2, singlet oxygen, upon illumination at 680 nm. Singlet oxygen has a limited lifetime prior to falling back to ground state. Within its 4 sec half-life, singlet oxygen can diffuse approximately 200 nm in solution. If an acceptor bead is within that proximity, energy is transferred from the singlet oxygen to thioxene derivatives within the acceptor bead, subsequently culminating in light production at 520-620 nm (AlphaScreen) or at 615 nm (AlphaLISA). In the absence of an acceptor bead, singlet oxygen falls to ground state and no signal is produced. When the proximity-based technology is AlphaScreen, the proximity signal can be the acceptor's emission intensity that is higher than a baseline level (e.g., about 2-fold, 5-fold, 10-fold, 20-fold, 50-fold, 100-fold higher or more). A baseline level here is the acceptor's emission intensity when the acceptor and the donor are apart (e.g., more than 200 nm, 300 nm, 400 nm, 500 nm, 1000 nm, 2000 nm apart).

[0096] In order to obtain proximity signal from the acceptor using the AlphaScreen or the AlphaLISA technology, the donor and the acceptor have to be in spatial proximity with each other. Thus, in certain embodiments, the assay components are labeled such that the donor and the acceptor can be about 1 nm, 5 nm, 10 nm, 25 nm, 50 nm, 75 nm, 100 nm, 125 nm, 150 nm, 175 nm, 200 nm apart from each other, or less than about 200 nm apart from each other to allow the proximity-dependent chemical energy transfer to occur.

[0097] In PCR-based proximity ligation assays, the donor and the acceptor each contains an oligonucleotide that can be ligated. The binding of the donor and the acceptor brings in close proximity the two oligonucleotides, which are then ligated, amplified, and detected by PCR.

[0098] In certain embodiments, the proximity-based measurement assay is carried out in a microplate. In specific embodiments, the proximity-based measurement assay is conducted in a high-throughput manner. In some embodiments, the donor and/or the acceptor is in the form of beads (e.g., AlphaScreen beads). In certain embodiments, the donor and/or the acceptor comprises streptavidin, avidin, or neutravidin (preferably streptavidin) that can bind to biotin conjugated to an assay component. In certain embodiments, the donor and/or the acceptor is directly conjugated to an assay component.

[0099] 5.2. The Assay Components

[0100] The substrate for Factor D is another alternative complement pathway serine protease, Factor B. Factor C3b binds to Factor B; then, Factor D cleaves Factor B into Factor Ba and Factor Bb. Factor Bb remains bound to Factor C3b, forming the active C3 convertase, which initiates the alternative complement pathway (Volanakis, et al., 1996, Protein Science 5:553-564). Therefore, if Factor B is not cleaved by Factor D, Factor Ba and Factor Bb will be in spatial proximity with each other, Factor C3b and Factor Ba will also be in spatial proximity with each other. When Factor B is cleaved by Factor D, however, Factor Ba and Factor Bb will be apart from each other, and Factor C3b and Factor Ba will also be apart from each other.

[0101] In certain embodiments, the methods described herein rely on the distance between Factor Ba and Factor Bb, wherein one of the two is labeled with a donor, and the other is labeled with an acceptor. In such embodiments, the donor and/or the acceptor may be attached to Factor Ba or Factor Bb, respectively, by a protein (e.g., an antibody or antigen-binding fragment thereof), peptide, peptide mimetic, aptamer, nucleotide (e.g., DNA, RNA, shRNA, miRNA, siRNA, antisense DNA), or any other molecule that binds to Factor Ba or Factor Bb, or by direct chemical labeling (when the donor is attached to Factor Ba, the acceptor is attached to Factor Bb; when the donor is attached to Factor Bb, the acceptor is attached to Factor Ba).

[0102] In certain embodiments, the methods described herein rely on the distance between Factor C3b and Factor Ba, wherein one of the two is labeled with a donor, and the other is labeled with an acceptor. In such embodiments, the donor and/or the acceptor may be attached to Factor C3b or Factor Ba, respectively, by a protein (e.g., an antibody or antigen-binding fragment thereof), peptide, peptide mimetic, aptamer, nucleotide (e.g., DNA, RNA, shRNA, miRNA, siRNA, antisense DNA), or any other molecule that binds to Factor C3b or Factor Ba, or by direct chemical labeling (when the donor is attached to Factor C3b, the acceptor is attached to Factor Ba; when the donor is attached to Factor Ba, the acceptor is attached to Factor C3b).

[0103] 5.3. Methods of Measuring Factor D Activity

[0104] In one aspect, provided herein are method of measuring the activity of Factor D in a sample derived from a subject, comprising performing a proximity-based measurement assay, wherein the proximity-based measurement assay measures the cleavage of Factor B. The proximity-based measurement assay can utilize any proximity-base technology known in the art for measuring the binding of a protein pair, as described in Section 5.1. The methods described in this section are useful, for example, in diagnosing or staging a human patient having or suspected of having a disorder associated with increased or decreased Factor D activity relative to a normal person.

[0105] In various embodiments, the methods of measuring the activity of Factor D comprise (a) adding to the sample an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety, wherein one of the moieties is a donor, and the other moiety is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor Ba and Factor Bb are in proximity; and (b) measuring the value of the proximity signal from the sample; wherein the activity of Factor D in the sample is negatively correlated with the value of the proximity signal.

[0106] In certain aspects of such various embodiments, the methods of measuring the activity of Factor D further comprise: (c) adding to a control sample the anti-Factor Ba antibody labeled with the first moiety and the anti-Factor Bb antibody labeled with the second moiety; and (d) measuring the value of the proximity signal from the control sample; wherein a greater value of the proximity signal from the sample relative to the control sample (e.g., about 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90% greater or more, or about 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, 10-fold, 15-fold, 20-fold, 30-fold, 40-fold, 50-fold greater or more) indicates a lower activity of Factor D in the sample relative to the control sample.

[0107] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the methods of measuring the activity of Factor D comprise: (A) adding to the sample an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety, wherein one of the moieties is a donor, and the other moiety is an acceptor; (B) providing a light source to excite the donor in the sample; and (C) measuring the donor fluorescence emission intensity from the sample, and/or the acceptor fluorescence emission intensity from the sample; wherein the activity of Factor D in the sample is positively correlated with the donor fluorescence emission intensity from the sample, and/or is negatively correlated with the acceptor fluorescence emission intensity from the sample. In certain embodiments, the step of (C) is performed after a period of time of the step of (B) that results in a decrease in interfering short-lived background signals. In specific embodiments, the methods of measuring the activity of Factor D further comprise: (D) adding to a control sample the anti-Factor Ba antibody labeled with the first moiety and the anti-Factor Bb antibody labeled with the second moiety; (E) providing the same light source to excite the donor in the control sample; and (F) measuring the donor fluorescence emission intensity from the control sample, and/or the acceptor fluorescence emission intensity from the control sample; wherein a lower donor fluorescence emission intensity from the sample relative to the control sample, and/or a higher acceptor fluorescence emission intensity from the sample relative to the control sample, indicates a lower activity of Factor D in the sample relative to the control sample. In certain embodiments, the step of (C) is performed after a period of time of the step of (B) that results in a decrease in interfering short-lived background signals, and the step of (F) is performed after the same period of time of the step of (E).

[0108] In certain embodiments, the anti-Factor Ba antibody and the anti-Factor Bb antibody used in the methods of measuring the activity of Factor D quench the activity of Factor D. In such embodiments, the need to add another quencher is obviated. In certain embodiments, the methods of measuring the activity of Factor D further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (a). When a control sample is used, in certain embodiments, the methods of measuring the activity of Factor D further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (a), and a step of quenching the activity of Factor D in the control sample by providing an excessive amount of the quencher to the control sample before the step of (c). In specific embodiments, the quencher is a Factor D inhibitor (for example, an anti-Factor D antibody or an excess amount of EDTA).

[0109] In certain embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin.

[0110] In other various embodiments, the methods of measuring the activity of Factor D comprise (a) adding to the sample an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety, wherein one of the moieties is a donor, and the other moiety is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor C3b and Factor Ba are in proximity; and (b) measuring the value of the proximity signal from the sample; wherein the activity of Factor D in the sample is negatively correlated with the value of the proximity signal.

[0111] In certain aspects of such other various embodiments, the methods of measuring the activity of Factor D further comprise: (c) adding to a control sample the anti-Factor C3b antibody labeled with the first moiety and the anti-Factor Ba antibody labeled with the second moiety; and (d) measuring the value of the proximity signal from the control sample; wherein a greater value of the proximity signal from the sample relative to the control sample (e.g., about 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90% greater or more, or about 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, 10-fold, 15-fold, 20-fold, 30-fold, 40-fold, 50-fold greater or more) indicates a lower activity of Factor D in the sample relative to the control sample.

[0112] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the methods of measuring the activity of Factor D comprise: (A) adding to the sample an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety, wherein one of the moieties is a donor, and the other moiety is an acceptor; (B) providing a light source to excite the donor in the sample; and (C) measuring the donor fluorescence emission intensity from the sample, and/or the acceptor fluorescence emission intensity from the sample; wherein the activity of Factor D in the sample is positively correlated with the donor fluorescence emission intensity from the sample, and/or is negatively correlated with the acceptor fluorescence emission intensity from the sample. In certain embodiments, the step of (C) is performed after a period of time of the step of (B) that results in a decrease in interfering short-lived background signals. In specific embodiments, the methods of measuring the activity of Factor D further comprise: (D) adding to a control sample the anti-Factor C3b antibody labeled with the first moiety and the anti-Factor Ba antibody labeled with the second moiety; (E) providing the same light source to excite the donor in the control sample; and (F) measuring the donor fluorescence emission intensity from the control sample, and/or the acceptor fluorescence emission intensity from the control sample; wherein a lower donor fluorescence emission intensity from the sample relative to the control sample, and/or a higher FRET acceptor fluorescence emission intensity from the sample relative to the control sample, indicates a lower activity of Factor D in the sample relative to the control sample. In certain embodiments, the step of (C) is performed after a period of time of the step of (B) that results in a decrease in interfering short-lived background signals, and the step of (F) is performed after the same period of time of the step of (E).

[0113] In certain embodiments wherein anti-Factor C3b antibody and anti-Factor Ba antibody are used, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin.

[0114] In certain embodiments wherein anti-Factor C3b antibody and anti-Factor Ba antibody are used, the anti-Factor C3b antibody and the anti-Factor Ba antibody used in the methods of measuring the activity of Factor D quench the activity of Factor D. In such embodiments, the need to add another quencher is obviated. In certain embodiments wherein anti-Factor C3b antibody and anti-Factor Ba antibody are used, the methods of measuring the activity of Factor D further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (a). When a control sample is used, in certain embodiments, the methods of measuring the activity of Factor D further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (a), and a step of quenching the activity of Factor D in the control sample by providing an excessive amount of the quencher to the control sample before the step of (c). In specific embodiments, the quencher is a Factor D inhibitor (for example, an anti-Factor D antibody or an excess amount of EDTA).

[0115] The sample can comprise a tissue, a population of cells directed isolated from the subject, a population of cultured cells derived from the subject, or a preparation from the tissue, the population of cells or the population of cultured cells that allows the activity of Factor D to be measured. When a control sample is used, the control sample is preferably in the same format as the sample. The control sample can be, but is not limited to, a sample with known Factor D activity or a sample with no Factor D activity. In specific embodiments, more than one control sample is used in the methods described herein. In certain embodiments, a standard curve has been generated for quantifying the activity of Factor D in samples without the need to measure a control sample.

[0116] The donor/acceptor pair can be any known in the art, or as described in Section 5.1.

[0117] The subject referred to in the methods described herein, can be, but is not limited to, a human or non-human vertebrate such as a wild, domestic or farm animal. In certain embodiments, the subject is a mammal, e.g., a human, a cow, a dog, a cat, a goat, a horse, a sheep, a pig, a rat, or a mouse. In a preferred embodiment, the subject is a human. In some embodiments, the subject is a human patient having or suspected of having a disorder associated with increased or decreased Factor D activity relative to a normal person, such as age-related macular degeneration (AMD). In some embodiments, the subject is a human patient having or suspected of having a disorder associated with excessive or uncontrolled complement activation. They include: complement activation during cardiopulmonary bypass operations; complement activation due to ischemia-reperfusion following acute myocardial infarction, aneurysm, stroke, hemorrhagic shock, crush injury, multiple organ failure, hypobolemic shock and intestinal ischemia. These disorders associated with excessive or uncontrolled complement activation can also include disease or condition is an inflammatory condition such as severe burns, endotoxemia, septic shock, adult respiratory distress syndrome, hemodialysis; anaphylactic shock, severe asthma, angioedema, Crohn's disease, sickle cell anemia, poststreptococcal glomerulonephritis and pancreatitis. The disorder may be the result of an adverse drug reaction, drug allergy, IL-2 induced vascular leakage syndrome or radiographic contrast media allergy. It also includes autoimmune disease such as systemic lupus erythematosus, myasthenia gravis, rheumatoid arthritis, Alzheimer's disease and multiple sclerosis. Complement activation is also associated with transplant rejection. Complement activation is also associated with ocular diseases (all ocular conditions and diseases the pathology of which involve complement, including the classical and the alternative pathway of complement), such as, for example, without limitation, macular degenerative disease, such as all stages of age-related macular degeneration (AMD), including dry and wet (non-exudative and exudative) forms, diabetic retinopathy and other ischemia-related retinopathies, choroidal neovascularization (CNV), uveitis, diabetic macular edema, pathological myopia, von Hippel-Lindau disease, histoplasmosis of the eye, Central Retinal Vein Occlusion (CRVO), corneal neovascularization, and retinal neovascularization. In one example, complement-associated eye conditions include age-related macular degeneration (AMD), including non-exudative (e.g intermediate dry AMD or geographic atrophy (GA)) and exudative (e.g. wet AMD (choroidal neovascularization (CNV)) AMD, diabetic retinopathy (DR), endophthalmitis and uveitis. In a further example, nonexudative AMD may include the presence of hard drusen, soft drusen, geographic atrophy and/or pigment clumping. In another example, complement-associated eye conditions include age-related macular degeneration (AMD), including early AMD (e.g. includes multiple small to one or more non-extensive medium sized drusen), intermediate AMD (e.g. includes extensive medium drusen to one or more large drusen) and advanced AMD (e.g. includes geographic atrophy or advanced wet AMD (CNV). In a further example, intermediate dry AMD may include large confluent drusen. In a further example, geographic atrophy may include photoreceptor and/or Retinal Pigmented Epithelial (RPE) loss. In a further example, the area of geographic atrophy may be small or large and/or may be in the macula area or in the peripheral retina. In one example, the complement-associated eye condition is intermediate dry AMD. In one example, the complement-associated eye condition is geographic atrophy. In one example, the complement-associated eye condition is wet AMD (choroidal neovascularization (CNV)).

[0118] In the methods of measuring the activity of Factor B described above, the anti-Factor Ba, anti-Factor Bb, and/or anti-Factor C3b may be replaced by a peptide, a non-antibody protein, a peptide memetic, an aptamer, a nucleotide (e.g., DNA, RNA, shRNA, miRNA, siRNA, antisense DNA), or any other molecule that binds to Factor Ba, Factor Bb, or anti-Factor C3b, respectively. Alternatively, the Factor Ba, Factor Bb, and/or Factor C3b may be directed attached to the donor or acceptor (as the case may be) by direct chemical labeling.

[0119] In specific embodiments of the methods of measuring the activity of Factor D described herein, the Factor B is a recombinantly expressed Factor B. In specific embodiments of the methods of measuring the activity of Factor D described herein, the Factor B is endogenously expressed Factor B purified from a sample derived from a subject.

[0120] The Factor D can be recombinantly expressed or endogenously expressed. In some embodiments, the Factor D is purified from the sample before the measuring of its activity.

[0121] The term sample referred to in the methods described herein, can be, but is not limited to, a blood sample or a serum sample.

[0122] 5.4. Methods of Determining the Potency of Factor D Inhibitor

[0123] In another aspect, provided herein are methods of determining the potency of a Factor D inhibitor in inhibiting Factor D activity, comprising performing a proximity-based measurement assay, wherein the proximity-based measurement assay measures the cleavage of Factor B. The proximity-based measurement assay can utilize any proximity-based technology known in the art for measuring the binding of a protein pair, as described in Section 5.1. The methods described in this section are useful, for example, in assessing the quality of anti-Factor D therapeutics for quality control in batch manufacturing, and in testing the potency of selected anti-Factor D therapeutic leads.

[0124] In various embodiments, the methods of determining the potency of a Factor D inhibitor comprise: (a) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor Ba and Factor Bb are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the potency of the Factor D inhibitor is positively correlated with the value of the proximity signal.

[0125] In certain aspects of such various embodiments, the methods of determining the potency of a Factor D inhibitor further comprise: (e) mixing a control reaction mix; (f) incubating the control reaction mix; (g) adding to the control reaction mix the anti-Factor Ba antibody labeled with the first moiety and the anti-Factor Bb antibody labeled with the second moiety after the step of (f); and (h) measuring the value of the proximity signal from the control test reaction mix; wherein a greater value of the proximity signal from the test reaction mix relative to the control reaction mix (e.g., about 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90% greater or more, or about 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, 10-fold, 15-fold, 20-fold, 30-fold, 40-fold, 50-fold greater or more) indicates a greater inhibition of Factor D activity by the Factor D inhibitor in the test reaction mix relative to the control reaction mix.

[0126] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the methods of determining the potency of a Factor D inhibitor comprise: (A) mixing the Factor D inhibitor with Factor D, Factor B and Factor C3b in a test reaction mix; (B) incubating the test reaction mix; (C) adding to the test reaction mix an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety after the step of (B), wherein one of the moieties is a donor, and the other moiety is an acceptor; (D) providing a light source to excite the donor in the test reaction mix; and (E) measuring the donor fluorescence emission intensity from the test reaction mix, and/or the acceptor fluorescence emission intensity from the test reaction mix; wherein the potency of the Factor D inhibitor is negatively correlated with the donor fluorescence emission intensity from the test reaction mix, and/or is positively correlated with the acceptor fluorescence emission intensity from the test reaction mix. In specific embodiments, the step of (B) is conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the step of (B) is conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (D) that results in a decrease in interfering short-lived background signals. In specific embodiments, the methods of determining the potency of a Factor D inhibitor further comprise: (F) mixing a control reaction mix; (G) incubating the control reaction mix; (H) adding to the control reaction mix the anti-Factor Ba antibody labeled with the first moiety and the anti-Factor Bb antibody labeled with the second moiety after the step of (G); (I) providing the same light source to excite the donor in the control reaction mix; and (J) measuring the donor fluorescence emission intensity from the control reaction mix, and/or the acceptor fluorescence emission intensity from the control reaction mix; wherein a lower donor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, and/or a higher acceptor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, indicates a greater inhibition of Factor D activity by the Factor D inhibitor in the test reaction mix relative to the control reaction mix. In specific embodiments, the steps of (B) and (G) are conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the steps of (B) and (G) are conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (D) that results in a decrease in interfering short-lived background signals, and the step of (J) is performed after the same period of time of the step of (I).

[0127] In certain embodiments, the anti-Factor Ba antibody and the anti-Factor Bb antibody used in the method of determining the potency of a Factor D inhibitor quench the activity of Factor D. In such embodiments, the need to add another quencher specifically is obviated. In certain embodiments, the method of determining the potency of a Factor D inhibitor further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c). When a control sample is used, in certain embodiments, the methods of measuring the activity of Factor D further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c), and a step of quenching the activity of Factor D in the control sample by providing an excessive amount of the quencher to the control sample before the step of (g). In specific embodiments, the quencher is a Factor D inhibitor (for example, an anti-Factor D antibody or an excess amount of EDTA).

[0128] In certain embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin.

[0129] In other various embodiments, the methods of determining the potency of a Factor D inhibitor comprise: (a) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor C3b and Factor Ba are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the potency of the Factor D inhibitor is positively correlated with the value of the proximity signal.

[0130] In certain aspects of such other various embodiments, the methods of determining the potency of a Factor D inhibitor further comprise: (e) mixing a control reaction mix; (f) incubating the control reaction mix; (g) adding to the control reaction mix the anti-Factor C3b antibody labeled with the first moiety and the anti-Factor Ba antibody labeled with the second moiety after the step of (f); and (h) measuring the value of the proximity signal from the control test reaction mix; wherein a greater value of the proximity signal from the test reaction mix relative to the control reaction mix (e.g., about 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90% greater or more, or about 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, 10-fold, 15-fold, 20-fold, 30-fold, 40-fold, 50-fold greater or more) indicates a greater inhibition of Factor D activity by the Factor D inhibitor in the test reaction mix relative to the control reaction mix.

[0131] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the methods of determining the potency of a Factor D inhibitor comprise: (A) mixing the Factor D inhibitor with Factor D, Factor B and Factor C3b in a test reaction mix; (B) incubating the test reaction mix; (C) adding to the test reaction mix an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety after the step of (B), wherein one of the moieties is a donor, and the other moiety is an acceptor; (D) providing a light source to excite the donor in the test reaction mix; and (E) measuring the donor fluorescence emission intensity from the test reaction mix, and/or the acceptor fluorescence emission intensity from the test reaction mix; wherein the potency of the Factor D inhibitor is negatively correlated with the donor fluorescence emission intensity from the test reaction mix, and/or is positively correlated with the acceptor fluorescence emission intensity from the test reaction mix. In specific embodiments, the step of (B) is conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the step of (B) is conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (D) that results in a decrease in interfering short-lived background signals. In specific embodiments, the methods of determining the potency of a Factor D inhibitor further comprise: (F) mixing a control reaction mix; (G) incubating the control reaction mix; (H) adding to the control reaction mix the anti-Factor C3b antibody labeled with the first moiety and the anti-Factor Ba antibody labeled with the second moiety after the step of (G); (I) providing said light source to excite the donor in the control reaction mix; and (J) measuring the donor fluorescence emission intensity from the control reaction mix, and/or the acceptor fluorescence emission intensity from the control reaction mix; wherein a lower donor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, and/or a higher acceptor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, indicates a greater inhibition of Factor D activity by the Factor D inhibitor in the test reaction mix relative to the control reaction mix. In specific embodiments, the steps of (B) and (G) are conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the steps of (B) and (G) are conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (D) that results in a decrease in interfering short-lived background signals, and the step of (J) is performed after the same period of time of the step of (I).

[0132] In certain embodiments wherein anti-Factor C3b antibody and anti-Factor Ba antibody are used, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin.

[0133] In certain embodiments wherein anti-Factor C3b antibody and anti-Factor Ba antibody are used, the anti-Factor C3b antibody and the anti-Factor Ba antibody used in the method of determining the potency of a Factor D inhibitor quench the activity of Factor D. In such embodiments, the need to add another quencher specifically is obviated. In certain embodiments wherein anti-Factor C3b antibody and anti-Factor Ba antibody are used, the method of determining the potency of a Factor D inhibitor further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c). When a control sample is used, in certain embodiments, the method of determining the potency of a Factor D inhibitor further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c), and a step of quenching the activity of Factor D in the control sample by providing an excessive amount of the quencher to the control sample before the step of (g). In specific embodiments, the quencher is a Factor D inhibitor (for example, an anti-Factor D antibody or an excess amount of EDTA).

[0134] The control reaction mix can comprise, for example, a different Factor D inhibitor with known potency (e.g., 100% potency) or no Factor D inhibitor, but contains everything else essentially the same as the test reaction mix. A quencher as described above can be used as a different Factor D inhibitor in the control reaction mix. In specific embodiments, more than one control reaction mix is used in the methods described herein. In certain embodiments, a standard curve has been generated for quantifying the potency of Factor D inhibitors in samples without the need to measure a control reaction mix.

[0135] The donor/acceptor pair can be any known in the art, or as described in Section 5.1.

[0136] The Factor D inhibitor can be any pharmaceutical agent that reduces or blocks the activity of Factor D.

[0137] In specific embodiments, the Factor D inhibitor is an antibody or an antigen-binding fragment thereof, for example, an antibody or an antigen-binding fragment thereof that binds to Factor D (see for example, International Patent Application Publication No. WO 1999/042133, International Patent Application Publication No. WO 2007/056227, International Patent Application Publication No. WO 2008/055206, International Patent Application Publication No. WO 2008/147883, and International Patent Application Publication No. WO 2009/134711, the disclosures of which are hereby incorporated by reference herein in their entireties). In some embodiments, the antibody is a murine antibody. In other embodiments, the antibody is a humanized antibody. In specific embodiments, the antibody is a bispecific antibody (e.g., a bispecific antibody that binds to Factor D and HTRA1). In some embodiments, the antibody is lampalizumab (see, International Patent Application Publication No. WO 2009/134711, the disclosure of which is hereby incorporated by reference herein in its entirety).

[0138] In some embodiments, the antibody comprises one, two, three, four, five or six of the following HVRs: (i) an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1; (ii) an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4; (iii) an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO: 7, or SEQ ID NO: 8; (iv) an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, or SEQ ID NO: 17; (v) an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18; or (vi) an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19 or SEQ ID NO: 20 (see Table 1).

[0139] In some embodiments, the antibody comprises one, two, three, four, five or six of the following HVRs: (i) an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85; (ii) an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88, SEQ ID NO: 89, SEQ ID NO: 90, SEQ ID NO: 91, SEQ ID NO: 92, SEQ ID NO: 93, or SEQ ID NO: 94; (iii) an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95; (iv) an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96; (v) an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, SEQ ID NO: 98, or SEQ ID NO: 99; or (vi) an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100 or SEQ ID NO: 101 (see Table 2).

TABLE-US-00001 TABLE1 HVRaminoacidsequences(inaccordancewithKabat+ ChothiaHVR definitions)ofanti-FactorDantibodies Antibody HVR-H1 HVR-H2 HVR-H3 HVR-L1 HVR-L2 HVR-L3 AFDWT GYTFTNYGMN WINTYTGET EGGVNN ITSTDIDDDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYADDFKG SEQIDNO:5 SEQIDNO:9 SEQIDNO:18 SEQIDNO:19 SEQIDNO:2 AFD.v1 GYTFTNYGMN WINTYTGET EGGVNN ITSTSIDDDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYADDFKG SEQIDNO:5 SEQIDNO:10 SEQIDNO:18 SEQIDNO:19 SEQIDNO:2 AFD.v2 GYTFTNYGMN WINTYTGET EGGVNN ITSTDIEDDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYADDFKG SEQIDNO:5 SEQIDNO:11 SEQIDNO:18 SEQIDNO:19 SEQIDNO:2 AFD.v3 GYTFTNYGMN WINTYTGET EGGVNN ITSTDIDSDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYADDFKG SEQIDNO:5 SEQIDNO:12 SEQIDNO:18 SEQIDNO:19 SEQIDNO:2 AFD.v4 GYTFTNYGMN WINTYTGET EGGVNN ITSTDIDDSMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYADDFKG SEQIDNO:5 SEQIDNO:13 SEQIDNO:18 SEQIDNO:19 SEQIDNO:2 AFD.v5 GYTFTNYGMN WINTYTGET EGGVNN ITSTSIDSSMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYADDFKG SEQIDNO:5 SEQIDNO:14 SEQIDNO:18 SEQIDNO:19 SEQIDNO:2 AFD.v6 GYTFTNYGMN WINTYTGET EGGVNN ITSTDIESDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:5 SEQIDNO:15 SEQIDNO:18 SEQIDNO:19 SEQIDNO:3 AFD.v7 GYTFTNYGMN WINTYTGET EGGVNN ITSTDIESDMN GGNTLRP LQSESLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:5 SEQIDNO:15 SEQIDNO:18 SEQIDNO:20 SEQIDNO:3 AFD.v8 GYTFTNYGMN WINTYTGET EGGVNN ITSTSIESDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:5 SEQIDNO:16 SEQIDNO:18 SEQIDNO:19 SEQIDNO:3 AFD.v9 GYTFTNYGMN WINTYTGET EGGVNN ITSTSIESDMS GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:5 SEQIDNO:17 SEQIDNO:18 SEQIDNO:19 SEQIDNO:3 AFD.v10 GYTFTNYGMN WINTYTGET EGGVNN ITSTSIESDMN GGNTLRP LQSESLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:5 SEQIDNO:16 SEQIDNO:18 SEQIDNO:20 SEQIDNO:3 AFD.v11 GYTFTNYGMN WISTYTGET EGGVNN ITSTSIESDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:5 SEQIDNO:16 SEQIDNO:18 SEQIDNO:19 SEQIDNO:4 AFD.v12 GYTFTNYGMN WINTYTGET EGGVDN ITSTSIESDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:6 SEQIDNO:16 SEQIDNO:18 SEQIDNO:19 SEQIDNO:3 AFD.v13 GYTFTNYGMN WINTYTGET EGGVQN ITSTSIESDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:7 SEQIDNO:16 SEQIDNO:18 SEQIDNO:19 SEQIDNO:3 AFD.v14 GYTFTNYGMN WINTYTGET EGGVSN ITSTSIESDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:3 SEQIDNO:8 SEQIDNO:16 SEQIDNO:18 SEQIDNO:19 AFD.v15 GYTFTNYGMN WINTYTGET EGGVSN ITSTSIESDMN GGNTLRP LQSDSLPYT SEQIDNO:1 TYAEDFKG SEQIDNO:8 SEQIDNO:16 SEQIDNO:18 SEQIDNO:20 SEQIDNO:3

TABLE-US-00002 TABLE2 HVRaminoacidsequences(inaccordancewithKabatHVRdefinitions)of additionalanti-FactorDantibodies Antibody HVR-H1 HVR-H2 HVR-H3 HVR-L1 HVR-L2 HVR-L3 murine SYYMY EINPTNGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT AFD SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:86 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.0 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:87 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.1 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:87 huAFD. SYYMY EINPYSGUIN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.3 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:88 huAFD. SYYMY EINPTNGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v1 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:86 huAFD. SYYMY EINPTQGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v1.1 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:89 huAFD. SYYMY EINPTSGDTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.2 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:90 huAFD. SYYMY EINPTSGETN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.4 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:91 huAFD. SYYMY EINPYSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.5 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:92 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.6 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:87 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.7 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:87 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.8 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:87 huAFD. SYYMY WINPTSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.9 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:93 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRKS QQYNNYPLT v2.10 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:98 SEQIDNO:100 SEQIDNO:87 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRRS QQYNNYPLT v2.11 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:99 SEQIDNO:100 SEQIDNO:87 huAFD. SYYMY EINPYSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.12 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:92 huAFD. SYYMY EINPTSGGTN EGGFAY KASQNVDTDVA SASSRYS QQYENYPLT v2.13 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:101 SEQIDNO:87 huAFD. SYYMY EINPTSGETN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.14 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:101 SEQIDNO:91 huAFD. SYYMY EINPYSGETN EGGFAY KASQNVDTDVA SASSRYS QQYNNYPLT v2.15 SEQIDNO:85 FNEKFKS SEQIDNO:95 SEQIDNO:96 SEQIDNO:97 SEQIDNO:100 SEQIDNO:94

[0140] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5.

[0141] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5.

[0142] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 4, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5.

[0143] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 6.

[0144] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 7.

[0145] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 8.

[0146] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 9, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0147] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 10, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0148] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 11, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0149] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 12, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0150] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 13, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0151] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 14, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0152] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 15, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0153] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 15, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 20.

[0154] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0155] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 17, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0156] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 20.

[0157] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 9, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0158] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 10, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0159] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 11, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0160] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 12, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0161] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 13, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0162] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 2, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 14, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0163] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 15, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0164] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 15, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 20.

[0165] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0166] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 17, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0167] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 20.

[0168] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 4, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0169] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 6, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0170] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 7, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0171] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 8, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 19.

[0172] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 1, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 3, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 8, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 16, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 18, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 20.

[0173] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 86, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0174] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 87, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0175] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 88, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0176] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 89, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0177] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 90, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0178] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 91, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0179] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 92, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0180] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 93, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0181] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 94, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95.

[0182] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0183] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 98, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0184] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 99, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0185] In some embodiments, the antibody comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 101.

[0186] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 86, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0187] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 87, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0188] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 88, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0189] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 89, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0190] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 90, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0191] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 91, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0192] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 92, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0193] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 93, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0194] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 87, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 98, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0195] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 87, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 99, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0196] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 87, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 101.

[0197] In some embodiments, the antibody comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 85, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 94, an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 95, an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 96, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 97, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 100.

[0198] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 21. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 21. See Table 3.

[0199] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 22. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 22. See Table 3.

[0200] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 21, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 22. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 21, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 22. See Table 3.

[0201] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 23. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 23. See Table 3.

[0202] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 24. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 24. See Table 3.

[0203] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 23, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 24. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 23, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 24. See Table 3.

[0204] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 25. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 25. See Table 3.

[0205] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 26. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 26. See Table 3.

[0206] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 25, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 26. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 25, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 26. See Table 3.

[0207] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 27. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 27. See Table 3.

[0208] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 28. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 28. See Table 3.

[0209] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 27, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 28. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 27, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 28. See Table 3.

[0210] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 29. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 29. See Table 3.

[0211] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 30. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 30. See Table 3.

[0212] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 29, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 30. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 29, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 30. See Table 3.

[0213] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 31. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 31. See Table 3.

[0214] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 32. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 32. See Table 3.

[0215] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 31, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 32. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 31, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 32. See Table 3.

[0216] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 33. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 33. See Table 3.

[0217] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 34. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 34. See Table 3.

[0218] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 33, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 34. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 33, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 34. See Table 3.

[0219] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 35. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 35. See Table 3.

[0220] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 36. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 36. See Table 3.

[0221] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 35, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 36. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 35, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 36. See Table 3.

[0222] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 37. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 37. See Table 3.

[0223] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 38. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 38. See Table 3.

[0224] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 37, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 38. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 37, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 38. See Table 3.

[0225] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 39. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 39. See Table 3.

[0226] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 40. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 40. See Table 3.

[0227] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 39, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 40. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 39, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 40. See Table 3.

[0228] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 41. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 41. See Table 3.

[0229] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 42. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 42. See Table 3.

[0230] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 41, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 42. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 41, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 42. See Table 3.

[0231] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 43. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 43. See Table 3.

[0232] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 44. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 44. See Table 3.

[0233] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 43, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 44. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 43, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 44. See Table 3.

[0234] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 45. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 45. See Table 3.

[0235] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 46. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 46. See Table 3.

[0236] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 45, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 46. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 45, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 46. See Table 3.

[0237] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 47. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 47. See Table 3.

[0238] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 48. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 48. See Table 3.

[0239] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 47, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 48. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 47, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 48. See Table 3.

[0240] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 49. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 49. See Table 3.

[0241] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 50. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 50. See Table 3.

[0242] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 49, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 50. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 49, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 50. See Table 3.

[0243] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 51. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 51. See Table 3.

[0244] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 52. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 52. See Table 3.

[0245] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 51, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 52. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 51, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 52. See Table 3.

TABLE-US-00003 TABLE3 Heavychainandlightchainvariabledomainaminoacidsequencesofanti- FactorDantibodies SEQID AFDWTHeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:21 VariableRegion WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFDWTLightChain DIQVTQSPSSLSASVGDRVTITCITSTDIDDDMNWYQQKPGKVPKLLISGGNT NO:22 VariableRegion LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v1HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:23 VariableRegion WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v1LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIDDDMNWYQQKPGKVPKLLISGGNT NO:24 VariableRegion LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v2HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:25 VariableRegion WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v2LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIEDDMNWYQQKPGKVPKLLISGGNT NO:26 VariableRegion LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v3HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:27 VariableRegion WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v3LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIDSDMNWYQQKPGKVPKLLISGGNT NO:28 VariableRegion LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v4HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:29 VariableRegion WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v4LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIDDSMNWYQQKPGKVPKLLISGGNT NO:30 VariableRegion LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v5HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:31 VariableRegion WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v5LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIDSSMNWYQQKPGKVPKLLISGGNTL NO:32 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v6HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:33 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v6LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIESDMNWYQQKPGKVPKLLISGGNT NO:34 VariableRegion LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v7HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:35 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v7LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIESDMNWYQQKPGKVPKLLISGGNT NO:36 VariableRegion LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSESLPYTFGQGTKVEIK SEQID AFD.v8HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:37 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v8LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:38 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v9HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:39 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v9LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMSWYQQKPGKVPKLLISGGNTL NO:40 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v10HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:41 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v10LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:42 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSESLPYTFGQGTKVEIK SEQID AFD.v11HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:43 VariableRegion WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSS SEQID AFD.v11LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:44 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v12HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:45 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSS SEQID AFD.v12LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:46 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v13HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:47 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSS SEQID AFD.v13LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:48 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v14HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:49 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSS SEQID AFD.v14LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:50 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK SEQID AFD.v15HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:51 VariableRegion WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSS SEQID AFD.v15LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:52 VariableRegion RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSESLPYTFGQGTKVEIK

[0246] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 102. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 102. See Table 4.

[0247] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 103. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 103. See Table 4.

[0248] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 102, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 103. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 102, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 103. See Table 4.

[0249] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 104. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 104. See Table 4.

[0250] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 105. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 105. See Table 4.

[0251] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 104, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 105. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 104, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 105. See Table 4.

[0252] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 106. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 106. See Table 4.

[0253] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 107. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 107. See Table 4.

[0254] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 106, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 107. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 106, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 107. See Table 4.

[0255] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 108. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 108. See Table 4.

[0256] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 109. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 109. See Table 4.

[0257] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 108, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 109. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 108, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 109. See Table 4.

[0258] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 110. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 110. See Table 4.

[0259] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 111. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 111. See Table 4.

[0260] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 110, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 111. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 110, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 111. See Table 4.

[0261] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 112. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 112. See Table 4.

[0262] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 113. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 113. See Table 4.

[0263] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 112, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 113. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 112, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 113. See Table 4.

[0264] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 114. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 114. See Table 4.

[0265] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 115. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 115. See Table 4.

[0266] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 114, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 115. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 114, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 115. See Table 4.

[0267] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 116. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 116. See Table 4.

[0268] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 117. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 117. See Table 4.

[0269] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 116, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 117. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 116, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 117. See Table 4.

[0270] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 118. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 118. See Table 4.

[0271] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 119. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 119. See Table 4.

[0272] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 118, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 119. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 118, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 119. See Table 4.

[0273] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 120. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 120. See Table 4.

[0274] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 121. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 121. See Table 4.

[0275] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 120, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 121. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 120, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 121. See Table 4.

[0276] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 122. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 122. See Table 4.

[0277] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 123. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 123. See Table 4.

[0278] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 122, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 123. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 122, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 123. See Table 4.

[0279] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 124. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 124. See Table 4.

[0280] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 125. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 125. See Table 4.

[0281] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 124, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 125. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 124, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 125. See Table 4.

[0282] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 126. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 126. See Table 4.

[0283] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 127. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 127. See Table 4.

[0284] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 126, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 127. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 126, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 127. See Table 4.

[0285] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 128. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 128. See Table 4.

[0286] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 129. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 129. See Table 4.

[0287] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 128, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 129. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 128, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 129. See Table 4.

[0288] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 130. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 130. See Table 4.

[0289] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 131. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 131. See Table 4.

[0290] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 130, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 131. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 130, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 131. See Table 4.

[0291] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 132. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 132. See Table 4.

[0292] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 133. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 133. See Table 4.

[0293] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 132, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 133. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 132, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 133. See Table 4.

[0294] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 134. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 134. See Table 4.

[0295] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 135. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 135. See Table 4.

[0296] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 134, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 135. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 134, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 135. See Table 4.

[0297] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 136. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 136. See Table 4.

[0298] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 137. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 137. See Table 4.

[0299] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 136, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 137. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 136, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 137. See Table 4.

[0300] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 138. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 138. See Table 4.

[0301] In some embodiments, the antibody comprises a light chain variable domain having the amino acid sequence of SEQ ID NO: 139. In some embodiments, the antibody comprises a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 139. See Table 4.

[0302] In some embodiments, the antibody comprises a heavy chain variable domain having the amino acid sequence of SEQ ID NO: 138, and a light chain variable domain having the amino acid sequence of SEQ ID NO: 139. In some embodiments, the antibody comprises a heavy chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 138, and a light chain variable domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 139. See Table 4.

TABLE-US-00004 TABLE4 Heavychainandlightchainvariabledomainaminoacidsequencesof additionalanti-FactorDantibodies SEQID murineAFDHeavy QVQLQQSGAELVKPGASVKLSCKASGYTFTSYYMYWVKERPGQGLEWIGEI NO:102 ChainVariableRegion NPTNGGTNFNEKFKSKATLTVDTSSNTAYMQLSSLTSEDSAVYYCAREGGF AYWGQGTLVTVSA SEQID murineAFDLight DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTDVAWFQQKPGQSPRGLIYSA NO:103 ChainVariableRegion SSRYSGVPDRFTGSGSGTDFTLTISNVQSEDLAEYFCQQYNNYPLTFGSGTK VEIK SEQID huAFD.v2.0Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:104 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.0Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:105 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.1Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:106 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.1Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:107 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.3Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:108 ChainVariableRegion INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.3Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:109 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v1Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:110 ChainVariableRegion INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF AYWGQGTLVTVSS SEQID huAFD.v1LightChain DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:111 VariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v1.1Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:112 ChainVariableRegion INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF AYWGQGTLVTVSS SEQID huAFD.v1.1Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:113 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.2Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:114 ChainVariableRegion INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.2Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:115 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.4Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:116 ChainVariableRegion INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.4Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:117 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.5Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:118 ChainVariableRegion INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.5Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:119 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.6Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:120 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.6Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLISSAS NO:121 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.7Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:122 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.7Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIKSAS NO:123 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.8Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:124 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.8Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIQSAS NO:125 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.9Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:126 ChainVariableRegion WINPTSGGTNFNEKFKSRATLTVDTSTSTAYELSSLRSEDTAVYYCAREGG FAYWGQGTLVTVSS SEQID huAFD.v2.9Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:127 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.10Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:128 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.10Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:129 ChainVariableRegion SRKSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.11Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:130 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.11Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:131 ChainVariableRegion SRRSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.12Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:132 ChainVariableRegion INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.12Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:133 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.13Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:134 ChainVariableRegion INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.13Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:135 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYENYPLTFGQGTKVE IK SEQID huAFD.v2.14Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:136 ChainVariableRegion INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.14Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:137 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK SEQID huAFD.v2.15Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:138 ChainVariableRegion INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSS SEQID huAFD.v2.15Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:139 ChainVariableRegion SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IK

[0303] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 53. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 53. See Table 5.

[0304] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 54. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 54. See Table 5.

[0305] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 53, and a light chain having the amino acid sequence of SEQ ID NO: 54. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 53, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 54. See Table 5.

[0306] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 55. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 55. See Table 5.

[0307] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 56. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 56. See Table 5.

[0308] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 55, and a light chain having the amino acid sequence of SEQ ID NO: 56. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 55, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 56. See Table 5.

[0309] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 57. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 57. See Table 5.

[0310] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 58. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 58. See Table 5.

[0311] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 57, and a light chain having the amino acid sequence of SEQ ID NO: 58. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 57, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 58. See Table 5.

[0312] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 59. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 59. See Table 5.

[0313] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 60. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 60. See Table 5.

[0314] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 59, and a light chain having the amino acid sequence of SEQ ID NO: 60. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 59, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 60. See Table 5.

[0315] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 61. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 61. See Table 5.

[0316] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 62. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 62. See Table 5.

[0317] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 61, and a light chain having the amino acid sequence of SEQ ID NO: 62. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 61, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 62. See Table 5.

[0318] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 63. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 63. See Table 5.

[0319] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 64. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 64. See Table 5.

[0320] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 63, and a light chain having the amino acid sequence of SEQ ID NO: 64. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 63, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 64. See Table 5.

[0321] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 65. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 65. See Table 5.

[0322] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 66. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 66. See Table 5.

[0323] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 65, and a light chain having the amino acid sequence of SEQ ID NO: 66. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 65, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 66. See Table 5.

[0324] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 67. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 67. See Table 5.

[0325] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 68. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 68. See Table 5.

[0326] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 67, and a light chain having the amino acid sequence of SEQ ID NO:

[0327] 68. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 67, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 68. See Table 5.

[0328] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 69. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 69. See Table 5.

[0329] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 70. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 70. See Table 5.

[0330] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 69, and a light chain having the amino acid sequence of SEQ ID NO: 70. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 69, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 70. See Table 5.

[0331] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 71. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 71. See Table 5.

[0332] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 72. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 72. See Table 5.

[0333] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 71, and a light chain having the amino acid sequence of SEQ ID NO: 72. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 71, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 72. See Table 5.

[0334] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 73. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 73. See Table 5.

[0335] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 74. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 74. See Table 5.

[0336] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 73, and a light chain having the amino acid sequence of SEQ ID NO: 74. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 73, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 74. See Table 5.

[0337] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 75. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 75. See Table 5.

[0338] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 76. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 76. See Table 5.

[0339] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 75, and a light chain having the amino acid sequence of SEQ ID NO: 76. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 75, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 76. See Table 5.

[0340] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 77. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 77. See Table 5.

[0341] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 78. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 78. See Table 5.

[0342] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 77, and a light chain having the amino acid sequence of SEQ ID NO:

[0343] 78. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 77, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 78. See Table 5.

[0344] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 79. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 79. See Table 5.

[0345] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 80. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 80. See Table 5.

[0346] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 79, and a light chain having the amino acid sequence of SEQ ID NO: 80. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 79, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 80. See Table 5.

[0347] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 81. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 81. See Table 5.

[0348] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 82. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 82. See Table 5.

[0349] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 81, and a light chain having the amino acid sequence of SEQ ID NO: 82. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 81, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 82. See Table 5.

[0350] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 83. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 83. See Table 5.

[0351] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 84. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 84. See Table 5.

[0352] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 83, and a light chain having the amino acid sequence of SEQ ID NO: 84. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 83, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 84. See Table 5.

TABLE-US-00005 TABLE5 Heavychainandlightchainaminoacidsequencesofanti-FactorD antibodies SEQID AFDWTHeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:53 WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSATKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFDWTLightChain DIQVTQSPSSLSASVGDRVTITCITSTDIDDDMNWYQQKPGKVPKLLISGGNT NO:54 LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v1HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:55 WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v1LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIDDDMNWYQQKPGKVPKLLISGGNT NO:56 LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v2HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:57 WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v2LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIEDDMNWYQQKPGKVPKLLISGGNT NO:58 LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v3HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:59 WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v3LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIDSDMNWYQQKPGKVPKLLISGGNT NO:60 LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v4HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:61 WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v4LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIDDSMNWYQQKPGKVPKLLISGGNT NO:62 LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v5HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:63 WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v5LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIDSSMNWYQQKPGKVPKLLISGGNTL NO:64 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v6HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:65 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v6LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIESDMNWYQQKPGKVPKLLISGGNT NO:66 LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v7HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:67 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v7LightChain DIQVTQSPSSLSASVGDRVTITCITSTDIESDMNWYQQKPGKVPKLLISGGNT NO:68 LRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSESLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v8HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:69 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v8LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:70 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v9HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:71 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v9LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMSWYQQKPGKVPKLLISGGNTL NO:72 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v10HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:73 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v10LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:74 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSESLPYTFGQGTKVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GEC SEQID AFD.v11HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:75 WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v11LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:76 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v12HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:77 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v12LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:78 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v13HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:79 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v13LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:80 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v14HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:81 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v14LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:82 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVIEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC SEQID AFD.v15HeavyChain EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:83 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID AFD.v15LightChain DIQVTQSPSSLSASVGDRVTITCITSTSIESDMNWYQQKPGKVPKLLISGGNTL NO:84 RPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSESLPYTFGQGTKVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GEC

[0353] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 140. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 140. See Table 6.

[0354] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 141. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 141. See Table 6.

[0355] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 140, and a light chain having the amino acid sequence of SEQ ID NO: 141. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 140, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 141. See Table 6.

[0356] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 142. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 142. See Table 6.

[0357] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 143. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 143. See Table 6.

[0358] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 142, and a light chain having the amino acid sequence of SEQ ID NO: 143. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 142, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 143. See Table 6.

[0359] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 144. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 144. See Table 6.

[0360] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 145. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 145. See Table 6.

[0361] In some embodiments, the antibody comprises a heavy having the amino acid sequence of SEQ ID NO: 144, and a light chain having the amino acid sequence of SEQ ID NO: 145. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 144, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 145. See Table 6.

[0362] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 146. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 146. See Table 6.

[0363] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 147. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 147. See Table 6.

[0364] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 146, and a light chain having the amino acid sequence of SEQ ID NO: 147. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 146, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 147. See Table 6.

[0365] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 148. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 148. See Table 6.

[0366] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 149. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 149. See Table 6.

[0367] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 148, and a light chain having the amino acid sequence of SEQ ID NO: 149. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 148, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 149. See Table 6.

[0368] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 150. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 150. See Table 6.

[0369] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 151. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 151. See Table 6.

[0370] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 150, and a light chain having the amino acid sequence of SEQ ID NO: 151. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 150, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 151. See Table 6.

[0371] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 152. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 152. See Table 6.

[0372] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 153. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 153. See Table 6.

[0373] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 152, and a light chain having the amino acid sequence of SEQ ID NO: 153. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 152, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 153. See Table 6.

[0374] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 154. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 154. See Table 6.

[0375] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 155. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 155. See Table 6.

[0376] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 154, and a light chain having the amino acid sequence of SEQ ID NO: 155. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 154, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 155. See Table 6.

[0377] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 156. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 156. See Table 6.

[0378] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 157. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 157. See Table 6.

[0379] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 156, and a light chain having the amino acid sequence of SEQ ID NO: 157. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 156, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 157. See Table 6.

[0380] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 158. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 158. See Table 6.

[0381] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 159. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 159. See Table 6.

[0382] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 158, and a light chain having the amino acid sequence of SEQ ID NO: 159. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 158, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 159. See Table 6.

[0383] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 160. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 160. See Table 6.

[0384] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 161. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 161. See Table 6.

[0385] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 160, and a light chain having the amino acid sequence of SEQ ID NO: 161. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 160, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 161. See Table 6.

[0386] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 162. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 162. See Table 6.

[0387] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 163. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 163. See Table 6.

[0388] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 162, and a light chain having the amino acid sequence of SEQ ID NO: 163. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 162, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 163. See Table 6.

[0389] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 164. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 164. See Table 6.

[0390] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 165. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 165. See Table 6.

[0391] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 164, and a light chain having the amino acid sequence of SEQ ID NO: 165. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 164, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 165. See Table 6.

[0392] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 166. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 166. See Table 6.

[0393] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 167. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 167. See Table 6.

[0394] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 166, and a light chain having the amino acid sequence of SEQ ID NO: 167. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 166, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 167. See Table 6.

[0395] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 168. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 168. See Table 6.

[0396] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 169. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 169. See Table 6.

[0397] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 168, and a light chain having the amino acid sequence of SEQ ID NO:

[0398] 169. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 168, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 169. See Table 6.

[0399] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 170. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 170. See Table 6.

[0400] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 171. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 171. See Table 6.

[0401] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 170, and a light chain having the amino acid sequence of SEQ ID NO: 171. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 170, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 171. See Table 6.

[0402] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 172. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 172. See Table 6.

[0403] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 173. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 173. See Table 6.

[0404] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 172, and a light chain having the amino acid sequence of SEQ ID NO: 173. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 172, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 173. See Table 6.

[0405] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 174. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 174. See Table 6.

[0406] In some embodiments, the antibody comprises a light chain having the amino acid sequence of SEQ ID NO: 175. In some embodiments, the antibody comprises a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 175. See Table 6.

[0407] In some embodiments, the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO: 174, and a light chain having the amino acid sequence of SEQ ID NO: 175. In some embodiments, the antibody comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 174, and a light chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 175. See Table 6.

TABLE-US-00006 TABLE6 Heavychainandlightchainaminoacidsequencesofadditionalanti-Factor Dantibodies SEQID huAFD.v2.0Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:140 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.0Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:141 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.1Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:142 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.1Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:143 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.3Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:144 Chain INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHT SEQID huAFD.v2.3Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:145 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v1Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:146 Chain INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHT SEQID huAFD.v1Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:147 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v1.1Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:148 Chain INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHT SEQID huAFD.v1.1Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:149 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.2Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:150 Chain INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.2Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:151 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.4Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:152 Chain INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.4Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:153 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.5Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:154 Chain INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHT SEQID huAFD.v2.5Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:155 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.6Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:156 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.6Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLISSAS NO:157 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.7Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:158 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.7Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIKSAS NO:159 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.8Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:160 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.8Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIQSAS NO:161 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.9Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:162 Chain WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHT SEQID huAFD.v2.9Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:163 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.10Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:164 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.10Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:165 Chain SRKSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.11Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:166 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.11Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSAS NO:167 Chain SRRSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.12Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:168 Chain INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHT SEQID huAFD.v2.12Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:169 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.13Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:170 Chain INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.13Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:171 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYENYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.14Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:172 Chain INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.14Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:173 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC SEQID huAFD.v2.15Heavy EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:174 Chain INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHT SEQID huAFD.v2.15Light DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSAS NO:175 Chain SRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC

[0408] The antibody and antigen-binding fragments described herein can also be further covalently modified by conjugating the antibody or antigen-binding fragments to one of a variety of non-proteinacious polymer molecules. The antibody-polymer conjugates can be made using any suitable technique for derivatizing antibody with polymers, and are not limited to conjugates utilizing any particular type of linkage between an antibody or antibody fragment and a polymer.

[0409] In one aspect, the conjugates include species wherein a polymer is covalently attached to a specific site or specific sites on the parental antibody, i.e. polymer attachment is targeted to a particular region or a particular amino acid residue or residues in the parental antibody or antibody fragment. Site specific conjugation of polymers is most commonly achieved by attachment to cysteine residues in the parental antibody or antibody fragment. In such embodiments, the coupling chemistry can, for example, utilize the free sulfhydryl group of a cysteine residue not in a disulfide bridge in the parental antibody. The polymer can be activated with any functional group that is capable of reacting specifically with the free sulfhydryl or thiol group(s) on the parental antibody, such as maleimide, sulfhydryl, thiol, triflate, tesylate, aziridine, exirane, and 5-pyridyl functional groups. The polymer can be coupled to the parental antibody using any protocol suitable for the chemistry of the coupling system selected, such as the protocols and systems described in U.S. Pat. Nos. 4,179,337; 7,122,636, and Jevsevar et al. (2010) Biotech. J. 5:113-128.

[0410] In some embodiments, one or more cysteine residue(s) naturally present in the parental antibody is (are) used as attachment site(s) for polymer conjugation. In some embodiments, one or more cysteine residue(s) is (are) engineered into a selected site or sites in the parental antibody for the purpose of providing a specific attachment site or sites for polymer. Cysteine engineered antibodies have been described previously (U.S. Pat. Pub. No. 2007/0092940 and Junutula, J. R., et al, J. Immunol Methods, Vol. 332(1-2), pp. 41-52 (2008), all herein incorporated by reference in their entirety). In some embodiments, cysteine engineered antibodies can be parental antibodies. These are useful for generating antibody fragments having a free cysteine in a particular location, typically in a constant region, e.g., CL or CH1. A parent antibody engineered to contain a cysteine may be referred to as a ThioMab and Fab fragments produced from such cysteine engineered antibodies, regardless of the method of production, may be referred as ThioMabs or ThioFabs. As described previously (see, e.g., U.S. Pat. Pub. No. 2007/0092940 and Junutula, J. R., et al, J. Immunol Methods, Vol. 332(1-2), pp. 41-52 (2008)), mutants with replaced (engineered) cysteine (Cys) residues are evaluated for the reactivity of the newly introduced, engineered cysteine thiol groups. The thiol reactivity value is a relative, numerical term in the range of 0 to 1.0 and can be measured for any cysteine engineered antibody. In addition to having a reactive thiol group, ThioMabs should be selected such that they retain antigen binding capability. The design, selection, and preparation of cysteine engineered antibodies were described in detail previously (see, e.g., WO 2011/069104, which is herein incorporated by reference). Engineered cysteines are preferably introduced into the constant domains of heavy or light chains. As such, the cysteine engineered antibodies will preferably retain the antigen binding capability of their wild type, parent antibody counterparts and, as such, are capable of binding specifically, to antigens.

[0411] In one aspect, the invention encompasses antibody-polymer conjugates, wherein the antibody is a Fab fragment, and the polymer is attached to one or more cysteine residue in the light or heavy chain of the Fab fragment that would ordinarily form the inter-chain disulfide bond linking the light and heavy chains. In some embodiments, one or more cysteine residue(s) naturally present in the hinge region of the antibody is (are) used to attach the polymer. In some embodiments, one or more cysteine residues is (are) engineered into the hinge region of the Fab fragment for the purpose of providing a specific attachment site or sites for polymer.

[0412] In another aspect, the invention encompasses antibody-polymer conjugates, wherein the antibody is a Fab-C or Fab fragment, and the polymer attachment is targeted to the hinge region of the Fab-C or Fab fragment. In some embodiments, one or more cysteine residue(s) naturally present in the hinge region of the antibody is (are) used to attach the polymer. In some embodiments, one or more cysteine residues is (are) added to the C-terminus of the Fab fragment for the purpose of providing a specific attachment site or sites for polymer.

[0413] In another aspect, the invention encompasses antibody-polymer conjugates, wherein the antibody is a F(ab)2 fragment, and the polymer attachment is targeted to the hinge region of the F(ab)2 fragment. In some embodiments, one or more cysteine residue(s) naturally present in the hinge region of the antibody is (are) used to attach the polymer. In some embodiments, one or more cysteine residues is (are) engineered into the hinge region of the F(ab)2 fragment for the purpose of providing a specific attachment site or sites for polymer.

[0414] In some embodiments, the anti-Factor D antibody (e.g., Fab fragment, Fab fragment, or F(ab)2 fragment) is modified by adding one cysteine at the C-terminal end of the heavy chain for the purpose of providing one attachment site for polymer conjugation. In some embodiments, the anti-Factor D antibody (e.g., Fab fragment, Fab fragment, or F(ab)2 fragment) is modified by adding four additional residues, Cys-Pro-Pro-Cys, at the C-terminal end of the heavy chain for the purpose of providing two attachment sites for polymer conjugation. In some embodiments, the anti-Factor D antibody (e.g., Fab fragment, Fab fragment, or F(ab)2 fragment) is modified by adding four additional residues, Cys-Pro-Pro-Ser, at the C-terminal end of the heavy chain for the purpose of providing one attachment site for polymer conjugation. In some embodiments, the anti-Factor D antibody (e.g., Fab fragment, Fab fragment, or F(ab)2 fragment) is modified by adding four additional residues, Ser-Pro-Pro-Cys, at the C-terminal end of the heavy chain for the purpose of providing one attachment site for polymer conjugation. In some embodiments, the anti-Factor D antibody (e.g., Fab fragment, Fab fragment, or F(ab)2 fragment) is modified by adding four additional residues, Ala-Pro-Pro-Cys, at the C-terminal end of the heavy chain for the purpose of providing one attachment site for polymer conjugation. In some embodiments, the anti-Factor D antibody (e.g., Fab fragment, Fab fragment, or F(ab)2 fragment) is modified by adding four additional residues, Ser-Gly-Gly-Cys, at the C-terminal end of the heavy chain for the purpose of providing one attachment site for polymer conjugation. In specific embodiments, the polymer conjugation is PEG polymer conjugation.

[0415] One commonly used antibody conjugation is PEGylation, wherein one or more polyethylene glycol (PEG) polymers are covalently attached to the antibody's constant region. See U.S. Pat. Nos. 4,179,337; 7,122,636. PEG polymers of different sizes (e.g., from about 500 D to about 300,000 D) and shapes (e.g., linear or branched) have been known and widely used in the field. The polymers useful for the present invention may be obtained commercially (e.g., from Nippon Oil and Fats; Nektar Therapeutics; Creative PEGWorks) or prepared from commercially available starting materials using conventional chemical procedures. PEGylation changes the physical and chemical properties of the antibody drug, and may results in improved pharmacokinetic behaviors such as improved stability, decreased immunogenicity, extended circulating life as well as increased residence time.

[0416] In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 176. In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 176. In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 176, wherein the cysteine at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 176, wherein the cysteine at the C Terminal end is attached to a polymer (e.g., a PEG polymer). See Table 7.

[0417] In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 177. In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 177. In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 177, wherein the two cysteines in the Cys-Pro-Pro-Cys sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 177, wherein the two cysteines in the Cys-Pro-Pro-Cys sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). See Table 7.

[0418] In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 178. In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 178. In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 178, wherein the cysteine at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 178, wherein the cysteine at the C Terminal end is attached to a polymer (e.g., a PEG polymer). See Table 7.

[0419] In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 179. In some embodiments, the antibody (e.g., a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 179. In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having the amino acid sequence of SEQ ID NO: 179, wherein the two cysteines in the Cys-Pro-Pro-Cys sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In some embodiments, the antibody (e.g., a Fab fragment, a Fab-C fragment or a F(ab)2 fragment) comprises a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 179, wherein the two cysteines in the Cys-Pro-Pro-Cys sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). See Table 7.

TABLE-US-00007 TABLE7 Heavychainandlightchainaminoacidsequencesofcysteine-modifiedanti- FactorDantibodies SEQID Cys-ModifiedAFD.v8 EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:176 HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID Cys-Pro-Pro-Cys- EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:177 ModifiedAFD.v8 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG HeavyChain VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID Cys-Modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:178 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID Cys-Pro-Pro-Cys- EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:179 ModifiedAFD.v14 WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG HeavyChain VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC

[0420] While Fab, Fab, Fab-C and F(ab)2 fragments provide the advantage of small size, short serum half-life, and lack of effector function, they typically include parts of the upper hinge region that can serve as neoepitopes, and are eventually recognized by the immune system and anti-hinge antibodies (AHA) are generated. These pre-existing AHA titers vary from donor to donor and may represent past and current exposure to neoepitopes. AHA can act as surrogate Fc and restore effector function of proteolytically inactivated antibodies. One reason to use a Fab, Fab, Fab-C or F(ab)2 molecule as therapeutic format is to eliminate effector function. Thus, it is undesired to have effector function reinstated by pre-existing AHA and risk any potential safety concerns. To evade recognition by pre-existing AHAs, the Fab, Fab, Fab-C or F(ab)2 fragments of an IgG2 or IgG4 isotype can be used. Alternatively, the heavy chain of the Fab of an IgG1 isotype can be modified to terminate with Cys-Asp or Cys-Asp-Lys-Thr-His-Leu.

[0421] In specific embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment of an IgG2 isotype. In specific embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment of an IgG4 isotype. In specific embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment of an IgG1 isotype.

[0422] In specific embodiments, the anti-Factor D antibody is a Fab fragment whose C-terminal of the heavy chain is modified to terminate with Cys-Asp (CD), Cys-Asp-Lys (CDK), Cys-Asp-Lys-Thr (CDKT), Cys-Asp-Lys-Thr-His (CDKTH), Cys-Asp-Lys-Thr-His-Thr (CDKTHT), or Cys-Asp-Lys-Thr-His-Leu (CDKTHL). In specific embodiments, the anti-Factor D antibody is a Fab fragment whose C-terminal of the heavy chain is modified to terminate with Cys-Asp (CD), Cys-Asp-Lys (CDK), Cys-Asp-Lys-Thr (CDKT), Cys-Asp-Lys-Thr-His (CDKTH), or Cys-Asp-Lys-Thr-His-Leu (CDKTHL). In specific embodiments, the anti-Factor D antibody is a Fab fragment whose C-terminal of the heavy chain is modified to terminate with Cys-Asp (CD) or Cys-Asp-Lys-Thr-His-Leu (CDKTHL). In specific embodiments, the anti-Factor D antibody is a Fab fragment whose C-terminal of the heavy chain is modified to terminate with Cys-Asp-Lys-Thr-His-X (CDKTHX), wherein X is any amino acid except Thr (T). The cysteine residue(s) may be attached to a polymer (e.g., a PEG polymer). In specific embodiments, the anti-Factor D antibody is a Fab fragment of an IgG1 isotype.

[0423] In specific embodiments, the anti-Factor D antibody is a Fab-C fragment whose C-terminal of the heavy chain is modified to terminate with Cys-Asp-Lys-Thr-His-Thr-Cys (CDKTHTC). In specific embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment whose C-terminal of the heavy chain is modified to terminate with Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC), Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Ser (CDKTHTCPPS), Cys-Asp-Lys-Thr-His-Thr-Ser-Pro-Pro-Cys (CDKTHTSPPC), Cys-Asp-Lys-Thr-His-Thr-Ala-Pro-Pro-Cys (CDKTHTAPPC), or Cys-Asp-Lys-Thr-His-Thr-Ser-Gly-Gly-Cys (CDKTHTSGGC). In specific embodiments, the anti-Factor D antibody is a Fab fragment whose C-terminal of the heavy chain is modified to terminate with Cys-Tyr-Gly-Pro-Pro-Cys (CYGPPC). One, two, or three of the cysteine residue(s) (as the case may be) may each be attached to a polymer (e.g., a PEG polymer). In specific embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment, a Fab-C fragment or a F(ab)2 fragment of an IgG1 isotype.

[0424] In specific embodiments, the anti-Factor D antibody is a Fab fragment whose C-terminal of the heavy chain is modified to terminate with Val-Glu-Arg-Lys (VERK). In specific embodiments, the anti-Factor D antibody is a Fab-C fragment whose C-terminal of the heavy chain is modified to terminate with Val-Glu-Arg-Lys-Cys (VERKC). The cysteine residue may be attached to a polymer (e.g., a PEG polymer). In specific embodiments, the anti-Factor D antibody is a Fab fragment or a Fab-C fragment of an IgG2 isotype.

[0425] In specific embodiments, the anti-Factor D antibody is a Fab fragment whose C-terminal of the heavy chain is modified to terminate with Lys-Tyr-Gly-Pro-Pro (KYGPP), Lys-Tyr-Gly-Pro (KYGP), Lys-Tyr-Gly (KYG), Lys-Tyr (KY), or Lys (K). In specific embodiments, the anti-Factor D antibody is a Fab-C fragment whose C-terminal of the heavy chain is modified to terminate with Lys-Tyr-Gly-Pro-Pro-Cys (KYGPPC). The cysteine residue may be attached to a polymer (e.g., a PEG polymer). In specific embodiments, the anti-Factor D antibody is a Fab fragmentor a Fab-C fragment of an IgG4 isotype.

[0426] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 180, SEQ ID NO: 181, SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190, SEQ ID NO: 191, SEQ ID NO: 192, SEQ ID NO: 193, SEQ ID NO: 194, SEQ ID NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199, SEQ ID NO: 200, SEQ ID NO: 201, SEQ ID NO: 202, SEQ ID NO: 203, SEQ ID NO: 204, SEQ ID NO: 205, SEQ ID NO: 206, SEQ ID NO: 207, SEQ ID NO: 208, SEQ ID NO: 209, SEQ ID NO: 210, SEQ ID NO: 211, SEQ ID NO: 212, or SEQ ID NO: 213. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 180, SEQ ID NO: 181, SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190, SEQ ID NO: 191, SEQ ID NO: 192, SEQ ID NO: 193, SEQ ID NO: 194, SEQ ID NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199, SEQ ID NO: 200, SEQ ID NO: 201, SEQ ID NO: 202, SEQ ID NO: 203, SEQ ID NO: 204, SEQ ID NO: 205, SEQ ID NO: 206, SEQ ID NO: 207, SEQ ID NO: 208, SEQ ID NO: 209, SEQ ID NO: 210, SEQ ID NO: 211, SEQ ID NO: 212, or SEQ ID NO: 213. See Table 8. In specific embodiments, the Fab fragment is of an IgG1 isotype. In specific embodiments, the cysteine in the Cys-Asp (CD) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0427] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 214, SEQ ID NO: 215, SEQ ID NO: 216, SEQ ID NO: 217, SEQ ID NO: 218, SEQ ID NO: 219, SEQ ID NO: 220, SEQ ID NO: 221, SEQ ID NO: 222, SEQ ID NO: 223, SEQ ID NO: 224, SEQ ID NO: 225, SEQ ID NO: 226, SEQ ID NO: 227, SEQ ID NO: 228, SEQ ID NO: 229, SEQ ID NO: 230, SEQ ID NO: 231, SEQ ID NO: 232, SEQ ID NO: 233, SEQ ID NO: 234, SEQ ID NO: 235, SEQ ID NO: 236, SEQ ID NO: 237, SEQ ID NO: 238, SEQ ID NO: 239, SEQ ID NO: 240, SEQ ID NO: 241, SEQ ID NO: 242, SEQ ID NO: 243, SEQ ID NO: 244, SEQ ID NO: 245, SEQ ID NO: 246, or SEQ ID NO: 247. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 214, SEQ ID NO: 215, SEQ ID NO: 216, SEQ ID NO: 217, SEQ ID NO: 218, SEQ ID NO: 219, SEQ ID NO: 220, SEQ ID NO: 221, SEQ ID NO: 222, SEQ ID NO: 223, SEQ ID NO: 224, SEQ ID NO: 225, SEQ ID NO: 226, SEQ ID NO: 227, SEQ ID NO: 228, SEQ ID NO: 229, SEQ ID NO: 230, SEQ ID NO: 231, SEQ ID NO: 232, SEQ ID NO: 233, SEQ ID NO: 234, SEQ ID NO: 235, SEQ ID NO: 236, SEQ ID NO: 237, SEQ ID NO: 238, SEQ ID NO: 239, SEQ ID NO: 240, SEQ ID NO: 241, SEQ ID NO: 242, SEQ ID NO: 243, SEQ ID NO: 244, SEQ ID NO: 245, SEQ ID NO: 246, or SEQ ID NO: 247. See Table 8. In specific embodiments, the Fab fragment is of an IgG1 isotype. In specific embodiments, the cysteine in the Cys-Asp-Lys-Thr-His-Leu (CDKTHL) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0428] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 248, SEQ ID NO: 249, SEQ ID NO: 250, SEQ ID NO: 251, SEQ ID NO: 252, SEQ ID NO: 253, SEQ ID NO: 254, SEQ ID NO: 255, SEQ ID NO: 256, SEQ ID NO: 257, SEQ ID NO: 258, SEQ ID NO: 259, SEQ ID NO: 260, SEQ ID NO: 261, SEQ ID NO: 262, SEQ ID NO: 263, SEQ ID NO: 264, SEQ ID NO: 265, SEQ ID NO: 266, SEQ ID NO: 267, SEQ ID NO: 268, SEQ ID NO: 269, SEQ ID NO: 270, SEQ ID NO: 271, SEQ ID NO: 272, SEQ ID NO: 273, SEQ ID NO: 274, SEQ ID NO: 275, SEQ ID NO: 276, SEQ ID NO: 277, SEQ ID NO: 278, SEQ ID NO: 279, SEQ ID NO: 280, or SEQ ID NO: 281. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 248, SEQ ID NO: 249, SEQ ID NO: 250, SEQ ID NO: 251, SEQ ID NO: 252, SEQ ID NO: 253, SEQ ID NO: 254, SEQ ID NO: 255, SEQ ID NO: 256, SEQ ID NO: 257, SEQ ID NO: 258, SEQ ID NO: 259, SEQ ID NO: 260, SEQ ID NO: 261, SEQ ID NO: 262, SEQ ID NO: 263, SEQ ID NO: 264, SEQ ID NO: 265, SEQ ID NO: 266, SEQ ID NO: 267, SEQ ID NO: 268, SEQ ID NO: 269, SEQ ID NO: 270, SEQ ID NO: 271, SEQ ID NO: 272, SEQ ID NO: 273, SEQ ID NO: 274, SEQ ID NO: 275, SEQ ID NO: 276, SEQ ID NO: 277, SEQ ID NO: 278, SEQ ID NO: 279, SEQ ID NO: 280, or SEQ ID NO: 281. See Table 8. In specific embodiments, the Fab fragment is of an IgG1 isotype. In specific embodiments, the cysteine in the Cys-Asp-Lys (CDK) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0429] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 282, SEQ ID NO: 283, SEQ ID NO: 284, SEQ ID NO: 285, SEQ ID NO: 286, SEQ ID NO: 287, SEQ ID NO: 288, SEQ ID NO: 289, SEQ ID NO: 290, SEQ ID NO: 291, SEQ ID NO: 292, SEQ ID NO: 293, SEQ ID NO: 294, SEQ ID NO: 295, SEQ ID NO: 296, SEQ ID NO: 297, SEQ ID NO: 298, SEQ ID NO: 299, SEQ ID NO: 300, SEQ ID NO: 301, SEQ ID NO: 302, SEQ ID NO: 303, SEQ ID NO: 304, SEQ ID NO: 305, SEQ ID NO: 306, SEQ ID NO: 307, SEQ ID NO: 308, SEQ ID NO: 309, SEQ ID NO: 310, SEQ ID NO: 311, SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 314, or SEQ ID NO: 315. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 282, SEQ ID NO: 283, SEQ ID NO: 284, SEQ ID NO: 285, SEQ ID NO: 286, SEQ ID NO: 287, SEQ ID NO: 288, SEQ ID NO: 289, SEQ ID NO: 290, SEQ ID NO: 291, SEQ ID NO: 292, SEQ ID NO: 293, SEQ ID NO: 294, SEQ ID NO: 295, SEQ ID NO: 296, SEQ ID NO: 297, SEQ ID NO: 298, SEQ ID NO: 299, SEQ ID NO: 300, SEQ ID NO: 301, SEQ ID NO: 302, SEQ ID NO: 303, SEQ ID NO: 304, SEQ ID NO: 305, SEQ ID NO: 306, SEQ ID NO: 307, SEQ ID NO: 308, SEQ ID NO: 309, SEQ ID NO: 310, SEQ ID NO: 311, SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 314, or SEQ ID NO: 315. See Table 8. In specific embodiments, the Fab fragment is of an IgG1 isotype. In specific embodiments, the cysteine in the Cys-Asp-Lys-Thr (CDKT) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0430] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 316, SEQ ID NO: 317, SEQ ID NO: 318, SEQ ID NO: 319, SEQ ID NO: 320, SEQ ID NO: 321, SEQ ID NO: 322, SEQ ID NO: 323, SEQ ID NO: 324, SEQ ID NO: 325, SEQ ID NO: 326, SEQ ID NO: 327, SEQ ID NO: 328, SEQ ID NO: 329, SEQ ID NO: 330, SEQ ID NO: 331, SEQ ID NO: 332, SEQ ID NO: 333, SEQ ID NO: 334, SEQ ID NO: 335, SEQ ID NO: 336, SEQ ID NO: 337, SEQ ID NO: 338, SEQ ID NO: 339, SEQ ID NO: 340, SEQ ID NO: 341, SEQ ID NO: 342, SEQ ID NO: 343, SEQ ID NO: 344, SEQ ID NO: 345, SEQ ID NO: 346, SEQ ID NO: 347, SEQ ID NO: 348, or SEQ ID NO: 349. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 316, SEQ ID NO: 317, SEQ ID NO: 318, SEQ ID NO: 319, SEQ ID NO: 320, SEQ ID NO: 321, SEQ ID NO: 322, SEQ ID NO: 323, SEQ ID NO: 324, SEQ ID NO: 325, SEQ ID NO: 326, SEQ ID NO: 327, SEQ ID NO: 328, SEQ ID NO: 329, SEQ ID NO: 330, SEQ ID NO: 331, SEQ ID NO: 332, SEQ ID NO: 333, SEQ ID NO: 334, SEQ ID NO: 335, SEQ ID NO: 336, SEQ ID NO: 337, SEQ ID NO: 338, SEQ ID NO: 339, SEQ ID NO: 340, SEQ ID NO: 341, SEQ ID NO: 342, SEQ ID NO: 343, SEQ ID NO: 344, SEQ ID NO: 345, SEQ ID NO: 346, SEQ ID NO: 347, SEQ ID NO: 348, or SEQ ID NO: 349. See Table 8. In specific embodiments, the Fab fragment is of an IgG1 isotype. In specific embodiments, the cysteine in the Cys-Asp-Lys-Thr-His (CDKTH) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0431] In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 350, SEQ ID NO: 351, SEQ ID NO: 352, SEQ ID NO: 353, SEQ ID NO: 354, SEQ ID NO: 355, SEQ ID NO: 356, SEQ ID NO: 357, SEQ ID NO: 358, SEQ ID NO: 359, SEQ ID NO: 360, SEQ ID NO: 361, SEQ ID NO: 362, SEQ ID NO: 363, SEQ ID NO: 364, SEQ ID NO: 365, SEQ ID NO: 366, SEQ ID NO: 367, SEQ ID NO: 368, SEQ ID NO: 369, SEQ ID NO: 370, SEQ ID NO: 371, SEQ ID NO: 372, SEQ ID NO: 373, SEQ ID NO: 374, SEQ ID NO: 375, SEQ ID NO: 376, SEQ ID NO: 377, SEQ ID NO: 378, SEQ ID NO: 379, SEQ ID NO: 380, SEQ ID NO: 381, SEQ ID NO: 382, or SEQ ID NO: 383. In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 350, SEQ ID NO: 351, SEQ ID NO: 352, SEQ ID NO: 353, SEQ ID NO: 354, SEQ ID NO: 355, SEQ ID NO: 356, SEQ ID NO: 357, SEQ ID NO: 358, SEQ ID NO: 359, SEQ ID NO: 360, SEQ ID NO: 361, SEQ ID NO: 362, SEQ ID NO: 363, SEQ ID NO: 364, SEQ ID NO: 365, SEQ ID NO: 366, SEQ ID NO: 367, SEQ ID NO: 368, SEQ ID NO: 369, SEQ ID NO: 370, SEQ ID NO: 371, SEQ ID NO: 372, SEQ ID NO: 373, SEQ ID NO: 374, SEQ ID NO: 375, SEQ ID NO: 376, SEQ ID NO: 377, SEQ ID NO: 378, SEQ ID NO: 379, SEQ ID NO: 380, SEQ ID NO: 381, SEQ ID NO: 382, or SEQ ID NO: 383. See Table 8. In specific embodiments, the Fab-C fragment is of an IgG1 isotype. In specific embodiments, the two cysteines in the Cys-Asp-Lys-Thr-His-Thr-Cys (CDKTHTC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys (CDKTHTC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys (CDKTHTC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0432] In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 384, SEQ ID NO: 385, SEQ ID NO: 386, SEQ ID NO: 387, SEQ ID NO: 388, SEQ ID NO: 389, SEQ ID NO: 390, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 393, SEQ ID NO: 394, SEQ ID NO: 395, SEQ ID NO: 396, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 399, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 403, SEQ ID NO: 404, SEQ ID NO: 405, SEQ ID NO: 406, SEQ ID NO: 407, SEQ ID NO: 408, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 411, SEQ ID NO: 412, SEQ ID NO: 413, SEQ ID NO: 414, SEQ ID NO: 415, SEQ ID NO: 416, or SEQ ID NO: 417. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 384, SEQ ID NO: 385, SEQ ID NO: 386, SEQ ID NO: 387, SEQ ID NO: 388, SEQ ID NO: 389, SEQ ID NO: 390, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 393, SEQ ID NO: 394, SEQ ID NO: 395, SEQ ID NO: 396, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 399, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 403, SEQ ID NO: 404, SEQ ID NO: 405, SEQ ID NO: 406, SEQ ID NO: 407, SEQ ID NO: 408, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 411, SEQ ID NO: 412, SEQ ID NO: 413, SEQ ID NO: 414, SEQ ID NO: 415, SEQ ID NO: 416, or SEQ ID NO: 417. See Table 8. In specific embodiments, the Fab fragment, Fab fragment or F(ab)2 fragment is of an IgG1 isotype. In specific embodiments, the three cysteines in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine and the third cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine and the third cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine and the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the third cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Cys (CDKTHTCPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0433] In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 418, SEQ ID NO: 419, SEQ ID NO: 420, SEQ ID NO: 421, SEQ ID NO: 422, SEQ ID NO: 423, SEQ ID NO: 424, SEQ ID NO: 425, SEQ ID NO: 426, SEQ ID NO: 427, SEQ ID NO: 428, SEQ ID NO: 429, SEQ ID NO: 430, SEQ ID NO: 431, SEQ ID NO: 432, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 435, SEQ ID NO: 436, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 439, SEQ ID NO: 440, SEQ ID NO: 441, SEQ ID NO: 442, SEQ ID NO: 443, SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 446, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 449, SEQ ID NO: 450, or SEQ ID NO: 451. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 418, SEQ ID NO: 419, SEQ ID NO: 420, SEQ ID NO: 421, SEQ ID NO: 422, SEQ ID NO: 423, SEQ ID NO: 424, SEQ ID NO: 425, SEQ ID NO: 426, SEQ ID NO: 427, SEQ ID NO: 428, SEQ ID NO: 429, SEQ ID NO: 430, SEQ ID NO: 431, SEQ ID NO: 432, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 435, SEQ ID NO: 436, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 439, SEQ ID NO: 440, SEQ ID NO: 441, SEQ ID NO: 442, SEQ ID NO: 443, SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 446, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 449, SEQ ID NO: 450, or SEQ ID NO: 451. See Table 8. In specific embodiments, the Fab fragment, Fab fragment or F(ab)2 fragment is of an IgG1 isotype. In specific embodiments, the two cysteines in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Ser (CDKTHTCPPS) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Ser (CDKTHTCPPS) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-Cys-Pro-Pro-Ser (CDKTHTCPPS) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0434] In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 454, SEQ ID NO: 455, SEQ ID NO: 456, SEQ ID NO: 457, SEQ ID NO: 458, SEQ ID NO: 459, SEQ ID NO: 460, SEQ ID NO: 461, SEQ ID NO: 462, SEQ ID NO: 463, SEQ ID NO: 464, SEQ ID NO: 465, SEQ ID NO: 466, SEQ ID NO: 467, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 470, SEQ ID NO: 471, SEQ ID NO: 472, SEQ ID NO: 473, SEQ ID NO: 474, SEQ ID NO: 475, SEQ ID NO: 476, SEQ ID NO: 477, SEQ ID NO: 478, SEQ ID NO: 479, SEQ ID NO: 480, SEQ ID NO: 481, SEQ ID NO: 482, SEQ ID NO: 483, SEQ ID NO: 484, or SEQ ID NO: 485. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 454, SEQ ID NO: 455, SEQ ID NO: 456, SEQ ID NO: 457, SEQ ID NO: 458, SEQ ID NO: 459, SEQ ID NO: 460, SEQ ID NO: 461, SEQ ID NO: 462, SEQ ID NO: 463, SEQ ID NO: 464, SEQ ID NO: 465, SEQ ID NO: 466, SEQ ID NO: 467, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 470, SEQ ID NO: 471, SEQ ID NO: 472, SEQ ID NO: 473, SEQ ID NO: 474, SEQ ID NO: 475, SEQ ID NO: 476, SEQ ID NO: 477, SEQ ID NO: 478, SEQ ID NO: 479, SEQ ID NO: 480, SEQ ID NO: 481, SEQ ID NO: 482, SEQ ID NO: 483, SEQ ID NO: 484, or SEQ ID NO: 485. See Table 8. In specific embodiments, the Fab fragment, Fab fragment or F(ab)2 fragment is of an IgG1 isotype. In specific embodiments, the two cysteines in the Cys-Asp-Lys-Thr-His-Thr-Ser-Pro-Pro-Cys (CDKTHTSPPC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine in the Cys-Asp-Lys-Thr-His-Thr-Ser-Pro-Pro-Cys (CDKTHTSPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-Ser-Pro-Pro-Cys (CDKTHTSPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0435] In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 486, SEQ ID NO: 487, SEQ ID NO: 488, SEQ ID NO: 489, SEQ ID NO: 490, SEQ ID NO: 491, SEQ ID NO: 492, SEQ ID NO: 493, SEQ ID NO: 494, SEQ ID NO: 495, SEQ ID NO: 496, SEQ ID NO: 497, SEQ ID NO: 498, SEQ ID NO: 499, SEQ ID NO: 500, SEQ ID NO: 501, SEQ ID NO: 502, SEQ ID NO: 503, SEQ ID NO: 504, SEQ ID NO: 505, SEQ ID NO: 506, SEQ ID NO: 507, SEQ ID NO: 508, SEQ ID NO: 509, SEQ ID NO: 510, SEQ ID NO: 511, SEQ ID NO: 512, SEQ ID NO: 513, SEQ ID NO: 514, SEQ ID NO: 515, SEQ ID NO: 516, SEQ ID NO: 517, SEQ ID NO: 518, or SEQ ID NO: 519. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 486, SEQ ID NO: 487, SEQ ID NO: 488, SEQ ID NO: 489, SEQ ID NO: 490, SEQ ID NO: 491, SEQ ID NO: 492, SEQ ID NO: 493, SEQ ID NO: 494, SEQ ID NO: 495, SEQ ID NO: 496, SEQ ID NO: 497, SEQ ID NO: 498, SEQ ID NO: 499, SEQ ID NO: 500, SEQ ID NO: 501, SEQ ID NO: 502, SEQ ID NO: 503, SEQ ID NO: 504, SEQ ID NO: 505, SEQ ID NO: 506, SEQ ID NO: 507, SEQ ID NO: 508, SEQ ID NO: 509, SEQ ID NO: 510, SEQ ID NO: 511, SEQ ID NO: 512, SEQ ID NO: 513, SEQ ID NO: 514, SEQ ID NO: 515, SEQ ID NO: 516, SEQ ID NO: 517, SEQ ID NO: 518, or SEQ ID NO: 519. See Table 8. In specific embodiments, the Fab fragment, Fab fragment or F(ab)2 fragment is of an IgG1 isotype. In specific embodiments, the two cysteines in the Cys-Asp-Lys-Thr-His-Thr-Ala-Pro-Pro-Cys (CDKTHTAPPC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine in the Cys-Asp-Lys-Thr-His-Thr-Ala-Pro-Pro-Cys (CDKTHTAPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-Ala-Pro-Pro-Cys (CDKTHTAPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0436] In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 520, SEQ ID NO: 521, SEQ ID NO: 522, SEQ ID NO: 523, SEQ ID NO: 524, SEQ ID NO: 525, SEQ ID NO: 526, SEQ ID NO: 527, SEQ ID NO: 528, SEQ ID NO: 529, SEQ ID NO: 530, SEQ ID NO: 531, SEQ ID NO: 532, SEQ ID NO: 533, SEQ ID NO: 534, SEQ ID NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO: 539, SEQ ID NO: 540, SEQ ID NO: 541, SEQ ID NO: 542, SEQ ID NO: 543, SEQ ID NO: 544, SEQ ID NO: 545, SEQ ID NO: 546, SEQ ID NO: 547, SEQ ID NO: 548, SEQ ID NO: 549, SEQ ID NO: 550, SEQ ID NO: 551, SEQ ID NO: 552, or SEQ ID NO: 553. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 520, SEQ ID NO: 521, SEQ ID NO: 522, SEQ ID NO: 523, SEQ ID NO: 524, SEQ ID NO: 525, SEQ ID NO: 526, SEQ ID NO: 527, SEQ ID NO: 528, SEQ ID NO: 529, SEQ ID NO: 530, SEQ ID NO: 531, SEQ ID NO: 532, SEQ ID NO: 533, SEQ ID NO: 534, SEQ ID NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO: 539, SEQ ID NO: 540, SEQ ID NO: 541, SEQ ID NO: 542, SEQ ID NO: 543, SEQ ID NO: 544, SEQ ID NO: 545, SEQ ID NO: 546, SEQ ID NO: 547, SEQ ID NO: 548, SEQ ID NO: 549, SEQ ID NO: 550, SEQ ID NO: 551, SEQ ID NO: 552, or SEQ ID NO: 553. See Table 8. In specific embodiments, the Fab fragment, Fab fragment or F(ab)2 fragment is of an IgG1 isotype. In specific embodiments, the two cysteines in the Cys-Asp-Lys-Thr-His-Thr-Ser-Gly-Gly-Cys (CDKTHTSGGC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine in the Cys-Asp-Lys-Thr-His-Thr-Ser-Gly-Gly-Cys (CDKTHTSGGC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-Ser-Gly-Gly-Cys (CDKTHTSGGC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0437] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 554, SEQ ID NO: 555, SEQ ID NO: 556, SEQ ID NO: 557, SEQ ID NO: 558, SEQ ID NO: 559, SEQ ID NO: 560, SEQ ID NO: 561, SEQ ID NO: 562, SEQ ID NO: 563, SEQ ID NO: 564, SEQ ID NO: 565, SEQ ID NO: 566, SEQ ID NO: 567, SEQ ID NO: 568, SEQ ID NO: 569, SEQ ID NO: 570, SEQ ID NO: 571, SEQ ID NO: 572, SEQ ID NO: 573, SEQ ID NO: 574, SEQ ID NO: 575, SEQ ID NO: 576, SEQ ID NO: 577, SEQ ID NO: 578, SEQ ID NO: 579, SEQ ID NO: 580, SEQ ID NO: 581, SEQ ID NO: 582, SEQ ID NO: 583, SEQ ID NO: 584, SEQ ID NO: 585, SEQ ID NO: 586, or SEQ ID NO: 587. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 554, SEQ ID NO: 555, SEQ ID NO: 556, SEQ ID NO: 557, SEQ ID NO: 558, SEQ ID NO: 559, SEQ ID NO: 560, SEQ ID NO: 561, SEQ ID NO: 562, SEQ ID NO: 563, SEQ ID NO: 564, SEQ ID NO: 565, SEQ ID NO: 566, SEQ ID NO: 567, SEQ ID NO: 568, SEQ ID NO: 569, SEQ ID NO: 570, SEQ ID NO: 571, SEQ ID NO: 572, SEQ ID NO: 573, SEQ ID NO: 574, SEQ ID NO: 575, SEQ ID NO: 576, SEQ ID NO: 577, SEQ ID NO: 578, SEQ ID NO: 579, SEQ ID NO: 580, SEQ ID NO: 581, SEQ ID NO: 582, SEQ ID NO: 583, SEQ ID NO: 584, SEQ ID NO: 585, SEQ ID NO: 586, or SEQ ID NO: 587. See Table 8. In specific embodiments, the Fab fragment is of an IgG1 isotype. In specific embodiments, the two cysteines in the Cys-Tyr-Gly-Pro-Pro-Cys (CYGPPC) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, the first cysteine in the Cys-Tyr-Gly-Pro-Pro-Cys (CYGPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, the second cysteine in the Cys-Tyr-Gly-Pro-Pro-Cys (CYGPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0438] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 588, SEQ ID NO: 589, SEQ ID NO: 590, SEQ ID NO: 591, SEQ ID NO: 592, SEQ ID NO: 593, SEQ ID NO: 594, SEQ ID NO: 595, SEQ ID NO: 596, SEQ ID NO: 597, SEQ ID NO: 598, SEQ ID NO: 599, SEQ ID NO: 600, SEQ ID NO: 601, SEQ ID NO: 602, SEQ ID NO: 603, SEQ ID NO: 604, SEQ ID NO: 605, SEQ ID NO: 606, SEQ ID NO: 607, SEQ ID NO: 608, SEQ ID NO: 609, SEQ ID NO: 610, SEQ ID NO: 611, SEQ ID NO: 612, SEQ ID NO: 613, SEQ ID NO: 614, SEQ ID NO: 615, SEQ ID NO: 616, SEQ ID NO: 617, SEQ ID NO: 618, SEQ ID NO: 619, SEQ ID NO: 620, or SEQ ID NO: 621. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 588, SEQ ID NO: 589, SEQ ID NO: 590, SEQ ID NO: 591, SEQ ID NO: 592, SEQ ID NO: 593, SEQ ID NO: 594, SEQ ID NO: 595, SEQ ID NO: 596, SEQ ID NO: 597, SEQ ID NO: 598, SEQ ID NO: 599, SEQ ID NO: 600, SEQ ID NO: 601, SEQ ID NO: 602, SEQ ID NO: 603, SEQ ID NO: 604, SEQ ID NO: 605, SEQ ID NO: 606, SEQ ID NO: 607, SEQ ID NO: 608, SEQ ID NO: 609, SEQ ID NO: 610, SEQ ID NO: 611, SEQ ID NO: 612, SEQ ID NO: 613, SEQ ID NO: 614, SEQ ID NO: 615, SEQ ID NO: 616, SEQ ID NO: 617, SEQ ID NO: 618, SEQ ID NO: 619, SEQ ID NO: 620, or SEQ ID NO: 621. See Table 8. In specific embodiments, the Fab fragment is of an IgG2 isotype.

[0439] In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 622, SEQ ID NO: 623, SEQ ID NO: 624, SEQ ID NO: 625, SEQ ID NO: 626, SEQ ID NO: 627, SEQ ID NO: 628, SEQ ID NO: 629, SEQ ID NO: 630, SEQ ID NO: 631, SEQ ID NO: 632, SEQ ID NO: 633, SEQ ID NO: 634, SEQ ID NO: 635, SEQ ID NO: 636, SEQ ID NO: 637, SEQ ID NO: 638, SEQ ID NO: 639, SEQ ID NO: 640, SEQ ID NO: 641, SEQ ID NO: 642, SEQ ID NO: 643, SEQ ID NO: 644, SEQ ID NO: 645, SEQ ID NO: 646, SEQ ID NO: 647, SEQ ID NO: 648, SEQ ID NO: 649, SEQ ID NO: 650, SEQ ID NO: 651, SEQ ID NO: 652, SEQ ID NO: 653, SEQ ID NO: 654, or SEQ ID NO: 655. In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 622, SEQ ID NO: 623, SEQ ID NO: 624, SEQ ID NO: 625, SEQ ID NO: 626, SEQ ID NO: 627, SEQ ID NO: 628, SEQ ID NO: 629, SEQ ID NO: 630, SEQ ID NO: 631, SEQ ID NO: 632, SEQ ID NO: 633, SEQ ID NO: 634, SEQ ID NO: 635, SEQ ID NO: 636, SEQ ID NO: 637, SEQ ID NO: 638, SEQ ID NO: 639, SEQ ID NO: 640, SEQ ID NO: 641, SEQ ID NO: 642, SEQ ID NO: 643, SEQ ID NO: 644, SEQ ID NO: 645, SEQ ID NO: 646, SEQ ID NO: 647, SEQ ID NO: 648, SEQ ID NO: 649, SEQ ID NO: 650, SEQ ID NO: 651, SEQ ID NO: 652, SEQ ID NO: 653, SEQ ID NO: 654, or SEQ ID NO: 655. See Table 8. In specific embodiments, the Fab-C fragment is of an IgG2 isotype. In specific embodiments, the cysteine in the Val-Glu-Arg-Lys-Cys (VERKC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0440] In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 656, SEQ ID NO: 657, SEQ ID NO: 658, SEQ ID NO: 659, SEQ ID NO: 660, SEQ ID NO: 661, SEQ ID NO: 662, SEQ ID NO: 663, SEQ ID NO: 664, SEQ ID NO: 665, SEQ ID NO: 666, SEQ ID NO: 667, SEQ ID NO: 668, SEQ ID NO: 669, SEQ ID NO: 670, SEQ ID NO: 671, SEQ ID NO: 672, SEQ ID NO: 673, SEQ ID NO: 674, SEQ ID NO: 675, SEQ ID NO: 676, SEQ ID NO: 677, SEQ ID NO: 678, SEQ ID NO: 679, SEQ ID NO: 680, SEQ ID NO: 681, SEQ ID NO: 682, SEQ ID NO: 683, SEQ ID NO: 684, SEQ ID NO: 685, SEQ ID NO: 686, SEQ ID NO: 687, SEQ ID NO: 688, or SEQ ID NO: 689. In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 656, SEQ ID NO: 657, SEQ ID NO: 658, SEQ ID NO: 659, SEQ ID NO: 660, SEQ ID NO: 661, SEQ ID NO: 662, SEQ ID NO: 663, SEQ ID NO: 664, SEQ ID NO: 665, SEQ ID NO: 666, SEQ ID NO: 667, SEQ ID NO: 668, SEQ ID NO: 669, SEQ ID NO: 670, SEQ ID NO: 671, SEQ ID NO: 672, SEQ ID NO: 673, SEQ ID NO: 674, SEQ ID NO: 675, SEQ ID NO: 676, SEQ ID NO: 677, SEQ ID NO: 678, SEQ ID NO: 679, SEQ ID NO: 680, SEQ ID NO: 681, SEQ ID NO: 682, SEQ ID NO: 683, SEQ ID NO: 684, SEQ ID NO: 685, SEQ ID NO: 686, SEQ ID NO: 687, SEQ ID NO: 688, or SEQ ID NO: 689. See Table 8. In specific embodiments, the Fab-C fragment is of an IgG4 isotype. In specific embodiments, the cysteine in the Lys-Tyr-Gly-Pro-Pro-Cys (KYGPPC) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

[0441] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 690, SEQ ID NO: 691, SEQ ID NO: 692, SEQ ID NO: 693, SEQ ID NO: 694, SEQ ID NO: 695, SEQ ID NO: 696, SEQ ID NO: 697, SEQ ID NO: 698, SEQ ID NO: 699, SEQ ID NO: 700, SEQ ID NO: 701, SEQ ID NO: 702, SEQ ID NO: 703, SEQ ID NO: 704, SEQ ID NO: 705, SEQ ID NO: 706, SEQ ID NO: 707, SEQ ID NO: 708, SEQ ID NO: 709, SEQ ID NO: 710, SEQ ID NO: 711, SEQ ID NO: 712, SEQ ID NO: 713, SEQ ID NO: 714, SEQ ID NO: 715, SEQ ID NO: 716, SEQ ID NO: 717, SEQ ID NO: 718, SEQ ID NO: 719, SEQ ID NO: 720, SEQ ID NO: 721, SEQ ID NO: 722, or SEQ ID NO: 723. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 690, SEQ ID NO: 691, SEQ ID NO: 692, SEQ ID NO: 693, SEQ ID NO: 694, SEQ ID NO: 695, SEQ ID NO: 696, SEQ ID NO: 697, SEQ ID NO: 698, SEQ ID NO: 699, SEQ ID NO: 700, SEQ ID NO: 701, SEQ ID NO: 702, SEQ ID NO: 703, SEQ ID NO: 704, SEQ ID NO: 705, SEQ ID NO: 706, SEQ ID NO: 707, SEQ ID NO: 708, SEQ ID NO: 709, SEQ ID NO: 710, SEQ ID NO: 711, SEQ ID NO: 712, SEQ ID NO: 713, SEQ ID NO: 714, SEQ ID NO: 715, SEQ ID NO: 716, SEQ ID NO: 717, SEQ ID NO: 718, SEQ ID NO: 719, SEQ ID NO: 720, SEQ ID NO: 721, SEQ ID NO: 722, or SEQ ID NO: 723. See Table 8. In specific embodiments, the Fab fragment is of an IgG4 isotype.

[0442] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 724, SEQ ID NO: 725, SEQ ID NO: 726, SEQ ID NO: 727, SEQ ID NO: 728, SEQ ID NO: 729, SEQ ID NO: 730, SEQ ID NO: 731, SEQ ID NO: 732, SEQ ID NO: 733, SEQ ID NO: 734, SEQ ID NO: 735, SEQ ID NO: 736, SEQ ID NO: 737, SEQ ID NO: 738, SEQ ID NO: 739, SEQ ID NO: 740, SEQ ID NO: 741, SEQ ID NO: 742, SEQ ID NO: 743, SEQ ID NO: 744, SEQ ID NO: 745, SEQ ID NO: 746, SEQ ID NO: 747, SEQ ID NO: 748, SEQ ID NO: 749, SEQ ID NO: 750, SEQ ID NO: 751, SEQ ID NO: 752, SEQ ID NO: 753, SEQ ID NO: 754, SEQ ID NO: 755, SEQ ID NO: 756, or SEQ ID NO: 757. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 724, SEQ ID NO: 725, SEQ ID NO: 726, SEQ ID NO: 727, SEQ ID NO: 728, SEQ ID NO: 729, SEQ ID NO: 730, SEQ ID NO: 731, SEQ ID NO: 732, SEQ ID NO: 733, SEQ ID NO: 734, SEQ ID NO: 735, SEQ ID NO: 736, SEQ ID NO: 737, SEQ ID NO: 738, SEQ ID NO: 739, SEQ ID NO: 740, SEQ ID NO: 741, SEQ ID NO: 742, SEQ ID NO: 743, SEQ ID NO: 744, SEQ ID NO: 745, SEQ ID NO: 746, SEQ ID NO: 747, SEQ ID NO: 748, SEQ ID NO: 749, SEQ ID NO: 750, SEQ ID NO: 751, SEQ ID NO: 752, SEQ ID NO: 753, SEQ ID NO: 754, SEQ ID NO: 755, SEQ ID NO: 756, or SEQ ID NO: 757. See Table 8. In specific embodiments, the Fab fragment is of an IgG4 isotype.

[0443] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 758, SEQ ID NO: 759, SEQ ID NO: 760, SEQ ID NO: 761, SEQ ID NO: 762, SEQ ID NO: 763, SEQ ID NO: 764, SEQ ID NO: 765, SEQ ID NO: 766, SEQ ID NO: 767, SEQ ID NO: 768, SEQ ID NO: 769, SEQ ID NO: 770, SEQ ID NO: 771, SEQ ID NO: 772, SEQ ID NO: 773, SEQ ID NO: 774, SEQ ID NO: 775, SEQ ID NO: 776, SEQ ID NO: 777, SEQ ID NO: 778, SEQ ID NO: 779, SEQ ID NO: 780, SEQ ID NO: 781, SEQ ID NO: 782, SEQ ID NO: 783, SEQ ID NO: 784, SEQ ID NO: 785, SEQ ID NO: 786, SEQ ID NO: 787, SEQ ID NO: 788, SEQ ID NO: 789, SEQ ID NO: 790, or SEQ ID NO: 791. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 758, SEQ ID NO: 759, SEQ ID NO: 760, SEQ ID NO: 761, SEQ ID NO: 762, SEQ ID NO: 763, SEQ ID NO: 764, SEQ ID NO: 765, SEQ ID NO: 766, SEQ ID NO: 767, SEQ ID NO: 768, SEQ ID NO: 769, SEQ ID NO: 770, SEQ ID NO: 771, SEQ ID NO: 772, SEQ ID NO: 773, SEQ ID NO: 774, SEQ ID NO: 775, SEQ ID NO: 776, SEQ ID NO: 777, SEQ ID NO: 778, SEQ ID NO: 779, SEQ ID NO: 780, SEQ ID NO: 781, SEQ ID NO: 782, SEQ ID NO: 783, SEQ ID NO: 784, SEQ ID NO: 785, SEQ ID NO: 786, SEQ ID NO: 787, SEQ ID NO: 788, SEQ ID NO: 789, SEQ ID NO: 790, or SEQ ID NO: 791. See Table 8. In specific embodiments, the Fab fragment is of an IgG4 isotype.

[0444] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 792, SEQ ID NO: 793, SEQ ID NO: 794, SEQ ID NO: 795, SEQ ID NO: 796, SEQ ID NO: 797, SEQ ID NO: 798, SEQ ID NO: 799, SEQ ID NO: 800, SEQ ID NO: 801, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 805, SEQ ID NO: 806, SEQ ID NO: 807, SEQ ID NO: 808, SEQ ID NO: 809, SEQ ID NO: 810, SEQ ID NO: 811, SEQ ID NO: 812, SEQ ID NO: 813, SEQ ID NO: 814, SEQ ID NO: 815, SEQ ID NO: 816, SEQ ID NO: 817, SEQ ID NO: 818, SEQ ID NO: 819, SEQ ID NO: 820, SEQ ID NO: 821, SEQ ID NO: 822, SEQ ID NO: 823, SEQ ID NO: 824, or SEQ ID NO: 825. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 792, SEQ ID NO: 793, SEQ ID NO: 794, SEQ ID NO: 795, SEQ ID NO: 796, SEQ ID NO: 797, SEQ ID NO: 798, SEQ ID NO: 799, SEQ ID NO: 800, SEQ ID NO: 801, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 805, SEQ ID NO: 806, SEQ ID NO: 807, SEQ ID NO: 808, SEQ ID NO: 809, SEQ ID NO: 810, SEQ ID NO: 811, SEQ ID NO: 812, SEQ ID NO: 813, SEQ ID NO: 814, SEQ ID NO: 815, SEQ ID NO: 816, SEQ ID NO: 817, SEQ ID NO: 818, SEQ ID NO: 819, SEQ ID NO: 820, SEQ ID NO: 821, SEQ ID NO: 822, SEQ ID NO: 823, SEQ ID NO: 824, or SEQ ID NO: 825. See Table 8. In specific embodiments, the Fab fragment is of an IgG4 isotype.

[0445] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 826, SEQ ID NO: 827, SEQ ID NO: 828, SEQ ID NO: 829, SEQ ID NO: 830, SEQ ID NO: 831, SEQ ID NO: 832, SEQ ID NO: 833, SEQ ID NO: 834, SEQ ID NO: 835, SEQ ID NO: 836, SEQ ID NO: 837, SEQ ID NO: 838, SEQ ID NO: 839, SEQ ID NO: 840, SEQ ID NO: 841, SEQ ID NO: 842, SEQ ID NO: 843, SEQ ID NO: 844, SEQ ID NO: 845, SEQ ID NO: 846, SEQ ID NO: 847, SEQ ID NO: 848, SEQ ID NO: 849, SEQ ID NO: 850, SEQ ID NO: 851, SEQ ID NO: 852, SEQ ID NO: 853, SEQ ID NO: 854, SEQ ID NO: 855, SEQ ID NO: 856, SEQ ID NO: 857, SEQ ID NO: 858, or SEQ ID NO: 859. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 792, SEQ ID NO: 826, SEQ ID NO: 827, SEQ ID NO: 828, SEQ ID NO: 829, SEQ ID NO: 830, SEQ ID NO: 831, SEQ ID NO: 832, SEQ ID NO: 833, SEQ ID NO: 834, SEQ ID NO: 835, SEQ ID NO: 836, SEQ ID NO: 837, SEQ ID NO: 838, SEQ ID NO: 839, SEQ ID NO: 840, SEQ ID NO: 841, SEQ ID NO: 842, SEQ ID NO: 843, SEQ ID NO: 844, SEQ ID NO: 845, SEQ ID NO: 846, SEQ ID NO: 847, SEQ ID NO: 848, SEQ ID NO: 849, SEQ ID NO: 850, SEQ ID NO: 851, SEQ ID NO: 852, SEQ ID NO: 853, SEQ ID NO: 854, SEQ ID NO: 855, SEQ ID NO: 856, SEQ ID NO: 857, SEQ ID NO: 858, or SEQ ID NO: 859. See Table 8. In specific embodiments, the Fab fragment is of an IgG4 isotype.

[0446] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having the amino acid sequence of SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 884, SEQ ID NO: 885, SEQ ID NO: 886, SEQ ID NO: 887, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 890, SEQ ID NO: 891, SEQ ID NO: 892, SEQ ID NO: 893, SEQ ID NO: 894, SEQ ID NO: 895, SEQ ID NO: 896, SEQ ID NO: 897, SEQ ID NO: 898, SEQ ID NO: 899, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 902, SEQ ID NO: 903, SEQ ID NO: 904, SEQ ID NO: 905, SEQ ID NO: 906, SEQ ID NO: 907, SEQ ID NO: 908, SEQ ID NO: 909, SEQ ID NO: 910, SEQ ID NO: 911, SEQ ID NO: 912, SEQ ID NO: 913, SEQ ID NO: 914, or SEQ ID NO: 915. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 884, SEQ ID NO: 885, SEQ ID NO: 886, SEQ ID NO: 887, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 890, SEQ ID NO: 891, SEQ ID NO: 892, SEQ ID NO: 893, SEQ ID NO: 894, SEQ ID NO: 895, SEQ ID NO: 896, SEQ ID NO: 897, SEQ ID NO: 898, SEQ ID NO: 899, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 902, SEQ ID NO: 903, SEQ ID NO: 904, SEQ ID NO: 905, SEQ ID NO: 906, SEQ ID NO: 907, SEQ ID NO: 908, SEQ ID NO: 909, SEQ ID NO: 910, SEQ ID NO: 911, SEQ ID NO: 912, SEQ ID NO: 913, SEQ ID NO: 914, or SEQ ID NO: 915. See Table 8. Here, X in the sequence of CDKTHX is any amino acid except T. In specific embodiments, the Fab fragment is of an IgG1 isotype. In specific embodiments, the cysteine in the Cys-Asp-Lys-Thr-His-Thr-X (CDKTHTX) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer). In specific embodiments, when X is C, the two cysteines in the Cys-Asp-Lys-Thr-His-Thr-X (CDKTHTX) sequence at the C Terminal end are each attached to a polymer (e.g., a PEG polymer). In specific embodiments, when X is C, the second cysteine in the Cys-Asp-Lys-Thr-His-Thr-X (CDKTHTX) sequence at the C Terminal end is attached to a polymer (e.g., a PEG polymer).

TABLE-US-00008 TABLE8 HeavychainandlightchainaminoacidsequencesofC' terminal-modified anti-FactorDantibodies SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:180 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:181 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:182 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:183 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:184 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:185 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:186 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:187 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:188 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:189 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:190 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:191 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:192 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:193 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:194 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:195 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:196 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:197 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:198 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:199 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:200 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:201 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:202 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:203 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:204 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:205 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:206 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:207 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:208 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:209 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:210 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:211 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:212 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:213 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCD SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:214 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:215 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:216 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:217 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:218 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:219 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:220 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:221 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:222 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:223 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:224 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:225 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:226 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:227 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:228 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:229 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:230 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:231 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:232 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:233 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:234 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:235 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:236 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:237 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:238 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:239 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:240 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:241 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:242 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:243 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:244 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:245 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:246 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:247 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHL SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:248 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:249 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:250 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:251 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:252 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:253 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:254 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:255 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:256 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:257 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:258 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:259 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:260 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:261 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:262 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:263 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:264 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:265 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:266 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:267 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:268 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:269 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:270 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:271 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:272 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:273 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:274 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:275 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:276 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:277 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:278 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:279 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:280 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:281 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:282 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:283 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:284 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:285 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:286 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:287 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:288 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:289 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:290 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:291 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:292 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:293 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:294 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:295 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:296 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:297 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:298 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:299 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:300 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:301 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:302 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:303 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:304 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:305 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:306 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:307 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:308 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:309 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:310 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:311 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:312 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:313 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:314 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:315 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKT SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:316 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:317 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:318 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:319 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:320 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:321 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:322 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:323 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:324 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:325 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:326 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:327 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:328 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:329 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:330 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:331 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:332 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:333 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:334 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:335 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:336 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:337 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:338 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:339 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:340 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:341 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:342 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:343 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:344 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:345 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:346 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:347 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:348 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:349 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTH SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:350 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:351 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:352 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:353 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:354 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:355 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:356 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:357 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:358 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:359 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:360 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:361 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:362 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:363 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:364 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:365 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:366 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:367 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:368 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:369 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:370 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:371 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:372 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:373 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:374 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:375 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:376 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:377 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:378 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:379 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:380 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:381 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:382 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:383 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:384 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:385 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:386 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:387 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:388 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:389 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:390 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:391 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:392 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:393 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:394 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:395 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:396 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:397 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:398 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:399 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:400 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:401 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:402 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:403 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:404 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:405 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:406 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:407 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:408 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:409 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:410 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:411 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:412 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:413 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:414 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:415 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:416 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:417 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:418 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:419 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:420 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:421 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:422 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:423 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:424 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:425 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:426 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:427 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:428 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:429 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:430 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:431 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:432 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:433 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:434 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:435 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:436 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:437 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:438 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:439 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:440 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:441 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:442 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:443 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:444 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:445 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:446 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:447 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:448 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:449 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:450 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:451 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPS SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:452 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:453 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:454 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:455 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:456 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:457 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:458 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:459 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:460 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:461 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:462 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:463 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:464 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:465 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:466 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:467 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:468 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:469 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:470 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:471 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:472 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:473 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:474 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:475 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:476 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:477 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:478 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:479 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:480 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:481 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:482 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:483 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:484 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:485 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:486 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:487 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:488 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:489 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:490 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:491 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:492 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:493 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:494 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:495 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:496 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:497 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:498 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:499 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:500 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:501 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:502 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:503 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:504 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:505 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:506 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:507 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:508 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:509 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:510 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:511 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:512 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:513 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:514 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:515 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:516 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:517 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:518 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:519 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTAPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:520 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:521 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:522 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:523 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:524 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:525 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:526 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:527 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:528 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:529 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:530 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:531 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:532 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:533 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:534 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:535 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:536 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:537 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:538 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS bWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:539 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:540 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:541 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:542 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:543 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:544 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:545 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:546 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:547 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:548 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:549 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:550 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:551 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:552 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:553 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHTSGGC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:554 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:555 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:556 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:557 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:558 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:559 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:560 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:561 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:562 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:563 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:564 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:565 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:566 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:567 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:568 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:569 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:570 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:571 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:572 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:573 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:574 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:575 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:576 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:577 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:578 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:579 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:580 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:581 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:582 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:583 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:584 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:585 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:586 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:587 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:588 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:589 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:590 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:591 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:592 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:593 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:594 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:595 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:596 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:597 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:598 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:599 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:600 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:601 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:602 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:603 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:604 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:605 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:606 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:607 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:608 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:609 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:610 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:611 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:612 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:613 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:614 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:615 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:616 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:617 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:618 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:619 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:620 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:621 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:622 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:623 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:624 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:625 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:626 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:627 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:628 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:629 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:630 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:631 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:632 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:633 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:634 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:635 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:636 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:637 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:638 huAFDv2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:639 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:640 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:641 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:642 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:643 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:644 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:645 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:646 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:647 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:648 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:649 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:650 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:651 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:652 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:653 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:654 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:655 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSVERKC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:656 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:657 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:658 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:659 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:660 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:661 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:662 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:663 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:664 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:665 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:666 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:667 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:668 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:669 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:670 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:671 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:672 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:673 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:674 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:675 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:676 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:677 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:678 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:679 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:680 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:681 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:682 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:683 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:684 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:685 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:686 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:687 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:688 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:689 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPPC SEQID C' terminal-modified AEVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:690 FDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:691 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:692 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:693 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:694 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:695 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:696 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:697 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:698 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:699 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:700 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:701 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:702 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:703 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:704 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:705 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:706 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:707 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:708 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:709 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:710 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:711 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:712 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:713 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:714 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:715 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:716 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:717 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:718 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:719 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:720 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:721 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:722 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:723 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGPP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:724 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:725 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:726 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:727 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:728 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:729 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:730 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:731 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:732 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:733 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:734 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:735 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:736 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:737 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:738 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:739 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:740 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:741 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:742 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:743 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:744 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:745 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:746 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:747 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:748 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:749 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:750 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:751 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:752 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:753 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:754 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:755 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:756 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:757 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYGP SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:758 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:759 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:760 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:761 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:762 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:763 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:764 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:765 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:766 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:767 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:768 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:769 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:770 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:771 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:772 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:773 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:774 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:775 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:776 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:777 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:778 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:779 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:780 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:781 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:782 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:783 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:784 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:785 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:786 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:787 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:788 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:789 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:790 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:791 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKYG SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:792 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:793 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:794 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:795 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:796 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:797 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:798 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:799 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:800 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:801 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:802 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:803 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:804 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:805 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:806 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:807 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:808 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:809 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:810 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:811 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:812 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:813 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:814 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:815 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:816 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:817 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:818 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:819 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:820 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:821 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:822 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:823 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:824 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:825 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSKY SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:826 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:827 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:828 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:829 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:830 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:831 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:832 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:833 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:834 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:835 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:836 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:837 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:838 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:839 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:840 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:841 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:842 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:843 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:844 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:845 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:846 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:847 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:848 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:849 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:850 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:851 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:852 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:853 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:854 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:855 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:856 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:857 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:858 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:859 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSK SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:882 AFDWTHeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:883 AFD.v1HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:884 AFD.v2HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:885 AFD.v3HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:886 AFD.v4HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:887 AFD.v5HeavyChain WINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:888 AFD.v6HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:889 AFD.v7HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:890 AFD.v8HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:891 AFD.v9HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:892 AFD.v10HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:893 AFD.v11HeavyChain WISTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:894 AFD.v12HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:895 AFD.v13HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VQNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:896 AFD.v14HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMG NO:897 AFD.v15HeavyChain WINTYTGETTYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG VSNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:898 huAFD.v2.0Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:899 huAFD.v2.1Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:900 huAFD.v2.3Heavy INPYSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:901 huAFD.v1Heavy INPTNGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:902 huAFD.v1.1Heavy INPTQGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGF Chain AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:903 huAFD.v2.2Heavy INPTSGDTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:904 huAFD.v2.4Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:905 huAFD.v2.5Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:906 huAFD.v2.6Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:907 huAFD.v2.7Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:908 huAFD.v2.8Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIG NO:909 huAFD.v2.9Heavy WINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGG Chain FAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS NTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:910 huAFD.v2.10Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:911 huAFD.v2.11Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:912 huAFD.v2.12Heavy INPYSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:913 huAFD.v2.13Heavy INPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:914 huAFD.v2.14Heavy INPTSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT) SEQID C' terminal-modified EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGE NO:915 huAFD.v2.15Heavy INPYSGETNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFA Chain YVVGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKKVEPKSCDKTHX(XisanyaminoacidexceptT)

[0447] In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a light chain constant region having the amino acid sequence of SEQ ID NO: 860. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a light chain constant region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 860. See Table 9.

[0448] In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain constant region having the amino acid sequence of SEQ ID NO: 861, SEQ ID NO: 862, SEQ ID NO: 869, SEQ ID NO: 870, SEQ ID NO: 871, SEQ ID NO: 872, SEQ ID NO: 873, SEQ ID NO: 874, SEQ ID NO: 877, SEQ ID NO: 878, SEQ ID NO: 879, SEQ ID NO: 880, SEQ ID NO: 881, or SEQ ID NO: 916. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain constant region having the amino acid sequence of SEQ ID NO: 864, SEQ ID NO: 865, SEQ ID NO: 866, SEQ ID NO: 867, or SEQ ID NO: 868. In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain constant region having the amino acid sequence of SEQ ID NO: 863, SEQ ID NO: 875, or SEQ ID NO: 876. In some embodiments, the anti-Factor D antibody is a Fab fragment comprising a heavy chain constant region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 861, SEQ ID NO: 862, SEQ ID NO: 869, SEQ ID NO: 870, SEQ ID NO: 871, SEQ ID NO: 872, SEQ ID NO: 873, SEQ ID NO: 874, SEQ ID NO: 877, SEQ ID NO: 878, SEQ ID NO: 879, SEQ ID NO: 880, SEQ ID NO: 881, or SEQ ID NO: 916. In some embodiments, the anti-Factor D antibody is a Fab fragment, a Fab fragment or a F(ab)2 fragment comprising a heavy chain constant region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 864, SEQ ID NO: 865, SEQ ID NO: 866, SEQ ID NO: 867, or SEQ ID NO: 868. In some embodiments, the anti-Factor D antibody is a Fab-C fragment comprising a heavy chain constant region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 863, SEQ ID NO: 875, or SEQ ID NO: 876. See Table 9.

TABLE-US-00009 TABLE9 Aminoacidsequencesofanti-FactorDantibodylightchainconstantregions andheavychainconstantregions SEQID RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS NO:860 STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:861 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:862 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHL SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:863 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTC SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:864 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPC SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:865 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPS SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:866 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTSPPC SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:867 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTAPPC SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:868 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTSGGC SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:869 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCYGPPC SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:870 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:871 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKT SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:872 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:873 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:874 VPSSNFGTQTYTCNVDHKPSNTKVDKTVERK SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:875 VPSSNFGTQTYTCNVDHKPSNTKVDKTVERKC SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:876 VPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPC SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:877 VPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPP SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:878 VPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGP SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:879 VPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYG SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:880 VPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY SEQID ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:881 VPSSSLGTKTYTCNVDHKPSNTKVDKRVESK SEQID ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT NO:916 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHX(XisanyaminoacidexceptT)

[0449] In specific embodiments, the Factor D inhibitor is a small molecule inhibitor. In specific embodiments, the Factor D inhibitor is a nucleotide (e.g., a DNA, an RNA, an shRNA, an miRNA, an siRNA, an antisense DNA). In specific embodiments, the Factor D inhibitor is a peptide, a protein, a peptide mimetic, an aptamer, or any other molecule that binds to Factor D.

[0450] In the methods of determining the potency of a Factor D inhibitor described above, the anti-Factor Ba, anti-Factor Bb, and/or anti-Factor C3b may be replaced by a peptide, a non-antibody protein, a peptide memetic, an aptamer, a nucleotide (e.g., DNA, RNA, shRNA, miRNA, siRNA, antisense DNA), or any other molecule that binds to Factor Ba, Factor Bb, or anti-Factor C3b, respectively. Alternatively, the Factor Ba, Factor Bb, and/or Factor C3b may be directed attached to the donor or acceptor (as the case may be) by direct chemical labeling.

[0451] In specific embodiments of the methods of determining the potency of a Factor D inhibitor described herein, the Factor D is a recombinantly expressed Factor D. In specific embodiments of the methods of determining the potency of a Factor D inhibitor described herein, the Factor D is endogenously expressed Factor D purified from a sample derived from a subject.

[0452] In specific embodiments of the methods of determining the potency of a Factor D inhibitor described herein, the Factor B is a recombinantly expressed Factor B. In specific embodiments of the methods of determining the potency of a Factor D inhibitor described herein, the Factor B is endogenously expressed Factor B purified from a sample derived from a subject.

[0453] The term sample referred to in the methods described herein, can be, but is not limited to, a blood sample or a serum sample.

[0454] The subject referred to in the methods described herein, can be, but is not limited to, a human or non-human vertebrate such as a wild, domestic or farm animal. In certain embodiments, the subject is a mammal, e.g., a human, a cow, a dog, a cat, a goat, a horse, a sheep, a pig, a rat, or a mouse. In a preferred embodiment, the subject is a human.

[0455] 5.5. Methods of Screening for Factor D Inhibitors

[0456] In another aspect, provided herein are methods of screening for a Factor D inhibitor from a plurality of Factor D inhibitor candidates, comprising performing a proximity-based measurement assay, wherein the proximity-based measurement assay measures the cleavage of Factor B. The proximity-based measurement assay can utilize any proximity-based technology known in the art for measuring the binding of a protein pair, as described in Section 5.1. The methods described in this section are useful, for example, in high-throughput screening for new Factor D inhibitors.

[0457] In various embodiments, the methods of screening for a Factor D inhibitor comprise: (a) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor Ba and Factor Bb are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the degree of Factor D activity inhibition by a Factor D candidate is positively correlated with the value of the proximity signal. In certain embodiments, the steps of (a)-(d) are carried out for each Factor D inhibitor candidate from the plurality.

[0458] In certain aspects of such various embodiments, the methods of screening for a Factor D inhibitor further comprise: (e) mixing a control reaction mix; (f) incubating the control reaction mix; (g) adding to the control reaction mix the anti-Factor Ba antibody labeled with the first moiety and the anti-Factor Bb antibody labeled with the second moiety after the step of (f); and (h) measuring the value of the proximity signal from the control test reaction mix; wherein a greater value of the proximity signal from the test reaction mix relative to the control reaction mix (e.g., about 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90% greater or more, or about 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, 10-fold, 15-fold, 20-fold, 30-fold, 40-fold, 50-fold greater or more) indicates a greater inhibition of Factor D activity by the Factor D inhibitor candidate in the test reaction mix relative to the control reaction mix.

[0459] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the methods of screening for a Factor D inhibitor comprise: (A) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (B) incubating the test reaction mix; (C) adding to the test reaction mix an anti-Factor Ba antibody labeled with a first moiety and an anti-Factor Bb antibody labeled with a second moiety after the step of (B), wherein one of the moieties is a donor, and the other is an acceptor; (D) providing a light source to excite the donor in the test reaction mix; and (E) measuring the donor fluorescence emission intensity from the test reaction mix, and/or the acceptor fluorescence emission intensity from the test reaction mix; wherein the degree of Factor D activity inhibition by a Factor D candidate is negatively correlated with the donor fluorescence emission intensity from the test reaction mix, and/or is positively correlated with the acceptor fluorescence emission intensity from the test reaction mix. In specific embodiments, the step of (B) is conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the step of (B) is conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (D) that results in a decrease in interfering short-lived background signals. In specific embodiments, the methods of screening for a Factor D inhibitor further comprise: (F) mixing a control reaction mix; (G) incubating the control reaction mix; (H) adding to the control reaction mix the anti-Factor Ba antibody labeled with the first moiety and the anti-Factor Bb antibody labeled with the second moiety after the step of (G); (I) providing the same light source to excite the donor in the control reaction mix; and (J) measuring the donor fluorescence emission intensity from the control reaction mix, and/or the acceptor fluorescence emission intensity from the control reaction mix; wherein a lower donor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, and/or a higher acceptor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, indicates a greater inhibition of Factor D activity by the Factor D inhibitor candidate in the test reaction mix relative to the control reaction mix. In specific embodiments, the steps of (B) and (G) are conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the steps of (B) and (G) are conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (D) that results in a decrease in interfering short-lived background signals, and the step of (J) is performed after the same period of time of the step of (J). In certain embodiments, the steps of (A)-(E) are carried out for each Factor D inhibitor candidate from the plurality.

[0460] In certain embodiments, the anti-Factor Ba antibody and the anti-Factor Bb antibody used in the methods of screening for a Factor D inhibitor quench the activity of Factor D. In such embodiments, the need to add another quencher specifically is obviated. In certain embodiments, the methods of screening for a Factor D inhibitor further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c). When a control sample is used, in certain embodiments, the methods of screening for a Factor D inhibitor further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c), and a step of quenching the activity of Factor D in the control sample by providing an excessive amount of the quencher to the control sample before the step of (g). In specific embodiments, the quencher is a Factor D inhibitor (for example, an anti-Factor D antibody or an excess amount of EDTA).

[0461] In certain embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin.

[0462] In other various embodiments, the methods of screening for a Factor D inhibitor comprise: (a) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (b) incubating the test reaction mix; (c) adding to the test reaction mix an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety after the step of (b), wherein one of the moieties is a donor, and the other is an acceptor, and wherein a proximity signal generated by the acceptor and/or the donor indicates that Factor C3b and Factor Ba are in proximity; and (d) measuring the value of the proximity signal from the test reaction mix; wherein the degree of Factor D activity inhibition by a Factor D candidate is positively correlated with the value of the proximity signal. In certain embodiments, the steps of (a)-(d) are carried out for each Factor D inhibitor candidate from the plurality.

[0463] In certain aspects of such other various embodiments, the methods of screening for a Factor D inhibitor further comprise: (e) mixing a control reaction mix; (f) incubating the control reaction mix; (g) adding to the control reaction mix the anti-Factor C3b antibody labeled with the first moiety and the anti-Factor Ba antibody labeled with the second moiety after the step of (f); and (h) measuring the value of the proximity signal from the control test reaction mix; wherein a greater value of the proximity signal from the test reaction mix relative to the control reaction mix (e.g., about 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90% greater or more, or about 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, 10-fold, 15-fold, 20-fold, 30-fold, 40-fold, 50-fold greater or more) indicates a greater inhibition of Factor D activity by the Factor D inhibitor candidate in the test reaction mix relative to the control reaction mix.

[0464] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the methods of screening for a Factor D inhibitor comprise: (A) mixing a Factor D inhibitor candidate with Factor D, Factor B and Factor C3b in a test reaction mix; (B) incubating the test reaction mix; (C) adding to the test reaction mix an anti-Factor C3b antibody labeled with a first moiety and an anti-Factor Ba antibody labeled with a second moiety after the step of (B), wherein one of the moieties is a donor, and the other is an acceptor; (D) providing a light source to excite the donor in the test reaction mix; and (E) measuring the donor fluorescence emission intensity from the test reaction mix, and/or the acceptor fluorescence emission intensity from the test reaction mix; wherein the degree of Factor D activity inhibition by a Factor D candidate is negatively correlated with the donor fluorescence emission intensity from the test reaction mix, and/or is positively correlated with the acceptor fluorescence emission intensity from the test reaction mix. In specific embodiments, the step of (B) is conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the step of (B) is conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (D) that results in a decrease in interfering short-lived background signals. In specific embodiments, the methods of screening for a Factor D inhibitor further comprise: (F) mixing a control reaction mix; (G) incubating the control reaction mix; (H) adding to the control reaction mix the anti-Factor C3b antibody labeled with the first moiety and the anti-Factor Ba antibody labeled with the second moiety after the step of (G); (I) providing said light source to excite the donor in the control reaction mix; and (J) measuring the donor fluorescence emission intensity from the control reaction mix, and/or the acceptor fluorescence emission intensity from the control reaction mix; wherein a lower donor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, and/or a higher acceptor fluorescence emission intensity from the test reaction mix relative to the control reaction mix, indicates a greater inhibition of Factor D activity by the Factor D inhibitor candidate in the test reaction mix relative to the control reaction mix. In specific embodiments, the steps of (B) and (G) are conducted for about 15 min, 30 min, 45 min, 60 min, 75 min, or 90 min. In some embodiments, the steps of (B) and (G) are conducted for about 45 min. In certain embodiments, the step of (E) is performed after a period of time of the step of (d) that results in a decrease in interfering short-lived background signals, and the step of (J) is performed after the same period of time of the step of (I). In certain embodiments, the steps of (A)-(E) are carried out for each Factor D inhibitor candidate from the plurality.

[0465] In certain embodiments when anti-Factor C3b antibody and anti-Factor Ba antibody are used, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin.

[0466] In certain embodiments when anti-Factor C3b antibody and anti-Factor Ba antibody are used, the anti-Factor C3b antibody and the anti-Factor Ba antibody used in the methods of screening for a Factor D inhibitor quench the activity of Factor D. In such embodiments, the need to add another quencher specifically is obviated. In certain embodiments when anti-Factor C3b antibody and anti-Factor Ba antibody are used, the methods of screening for a Factor D inhibitor further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c). When a control sample is used, in certain embodiments, the methods of screening for a Factor D inhibitor further comprise a step of quenching the activity of Factor D in the sample by providing an excessive amount of a quencher to the sample before the step of (c), and a step of quenching the activity of Factor D in the control sample by providing an excessive amount of the quencher to the control sample before the step of (g). In specific embodiments, the quencher is a Factor D inhibitor (for example, an anti-Factor D antibody or an excess amount of EDTA).

[0467] The control reaction mix can comprise, for example, a different Factor D inhibitor with known potency (e.g., 100% potency) or no Factor D inhibitor, but contains everything else essentially the same as the test reaction mix. In specific embodiments, more than one control reaction mix is used in the methods described herein. In certain embodiments, a standard curve has been generated for screening for Factor D inhibitors without the need to measure a control reaction mix.

[0468] The donor/acceptor pair can be any known in the art, or as described in Section 5.1.

[0469] The Factor D inhibitor candidate can be any pharmaceutical agent that may reduce or block the activity of Factor D. In specific embodiments, the Factor D inhibitor candidate is an antibody or an antigen-binding fragment thereof, for example, an antibody or an antigen-binding fragment thereof that binds to Factor D. In specific embodiments, the antibody is a bispecific antibody. In specific embodiments, the Factor D inhibitor candidate is a small molecule inhibitor. In specific embodiments, the Factor D inhibitor candidate is a nucleotide (e.g., a DNA, an RNA, an shRNA, an miRNA, an siRNA, an antisense DNA). In specific embodiments, the Factor D inhibitor candidate is a peptide, a protein, a peptide mimetic, an aptamer, or any other molecule that binds to Factor D.

[0470] In the methods of screening for a Factor D inhibitor described above, the anti-Factor Ba, anti-Factor Bb, and/or anti-Factor C3b may be replaced by a peptide, a non-antibody protein, a peptide memetic, an aptamer, a nucleotide (e.g., DNA, RNA, shRNA, miRNA, siRNA, antisense DNA), or any other molecule that binds to Factor Ba, Factor Bb, or anti-Factor C3b, respectively. Alternatively, the Factor Ba, Factor Bb, and/or Factor C3b may be directed attached to the donor or acceptor (as the case may be) by direct chemical labeling.

[0471] In specific embodiments of the methods of screening for a Factor D inhibitor described herein, the Factor D is a recombinantly expressed Factor D. In specific embodiments of the methods of screening for a Factor D inhibitor described herein, the Factor D is endogenously expressed Factor D purified from a sample derived from a subject.

[0472] In specific embodiments of the methods of screening for a Factor D inhibitor described herein, the Factor B is a recombinantly expressed Factor B. In specific embodiments of the methods of screening for a Factor D inhibitor described herein, the Factor B is endogenously expressed Factor B purified from a sample derived from a subject.

[0473] The term sample referred to in the methods described herein, can be, but is not limited to, a blood sample or a serum sample.

[0474] The subject referred to in the methods described herein, can be, but is not limited to, a human or non-human vertebrate such as a wild, domestic or farm animal. In certain embodiments, the subject is a mammal, e.g., a human, a cow, a dog, a cat, a goat, a horse, a sheep, a pig, a rat, or a mouse. In a preferred embodiment, the subject is a human.

[0475] 5.6. Kits

[0476] In another aspect, provided herein are kits for measuring Factor D activity, determining Factor D inhibitor potency, and/or screening for Factor D inhibitors. The kits described herein can be used in accordance with any methods described above as appropriate.

[0477] In various embodiments, the kits comprise an anti-Factor Ba antibody, an anti-Factor Bb antibody, a first moiety and a second moiety, wherein: (a) the anti-Factor Ba antibody is labeled or can be labeled with the first moiety, the anti-Factor Bb antibody is labeled or can be labeled with the second moiety; and (b) one of the moieties is a donor, and the other moiety is an acceptor. When using the kits, in specific embodiments a proximity signal can be generated by the donor and/or the acceptor, which indicates that the acceptor and the donor are in proximity.

[0478] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the kits comprise an anti-Factor Ba antibody, an anti-Factor Bb antibody, a first moiety and a second moiety, wherein: (a) the anti-Factor Ba antibody is labeled or can be labeled with the first moiety, the anti-Factor Bb antibody is labeled or can be labeled with the second moiety; and (b) one of the moieties is a donor, and the other moiety is an acceptor. When using the kits, in specific embodiments upon excitation by a light source the ratio between the acceptor fluorescence emission intensity and the donor fluorescence emission intensity that is higher than a baseline level indicates that the donor and the acceptor are in proximity (a baseline level here is the ratio between the acceptor's fluorescence emission intensity and the donor's fluorescence emission intensity when the acceptor and the donor are apart (e.g., more than 10 nm, 20 nm, 50 nm, 100 nm, or 200 nm apart)).

[0479] In specific embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Bb antibody is biotinylated, and the second moiety comprises streptavidin.

[0480] In specific embodiments, the anti-Factor Ba antibody and/or the anti-Factor Bb antibody is immobilized on a solid surface. In specific embodiments, the solid surface is a plate, a microplate, a chip, a membrane, or a bead.

[0481] In other various embodiments, the kits comprise an anti-Factor C3b antibody, an anti-Factor Ba antibody, a first moiety and a second moiety, wherein: (a) the anti-Factor C3b antibody is labeled or can be labeled with the first moiety, the anti-Factor Ba antibody is labeled or can be labeled with the second moiety; and (b) one of the moieties is a donor, and the other moiety is an acceptor. When using the kits, in specific embodiments a proximity signal can be generated by the donor and/or the acceptor, which indicates that the acceptor and the donor are in proximity.

[0482] When the proximity signal generated by the donor and/or the acceptor is based on energy transfer between the donor and the acceptor upon light activation, in various embodiments, the kits comprise an anti-Factor C3b antibody, an anti-Factor Ba antibody, a first moiety and a second moiety, wherein: (a) the anti-Factor C3b antibody is labeled or can be labeled with the first moiety, the anti-Factor Ba antibody is labeled or can be labeled with the second moiety; and (b) one of the moieties is a donor, and the other moiety is an acceptor. When using the kits, in specific embodiments upon excitation by a light source the ratio between the acceptor fluorescence emission intensity and the donor fluorescence emission intensity that is higher than a baseline level indicates that the donor and the acceptor are in proximity (a baseline level here is the ratio between the acceptor's fluorescence emission intensity and the donor's fluorescence emission intensity when the acceptor and the donor are apart (e.g., more than 10 nm, 20 nm, 50 nm, 100 nm, or 200 nm apart)).

[0483] In specific embodiments, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor C3b antibody is biotinylated, and the first moiety comprises streptavidin. In certain embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin, avidin, or neutravidin. In some embodiments, the anti-Factor Ba antibody is biotinylated, and the second moiety comprises streptavidin.

[0484] In specific embodiments, the anti-Factor C3b antibody and/or the anti-Factor Ba antibody is immobilized on a solid surface. In specific embodiments, the solid surface is a plate, a microplate, a chip, a membrane, or a bead.

[0485] In certain embodiments, the kits described herein further comprise a control sample with known Factor D activity.

[0486] In certain embodiments, the kits described herein further comprise a control Factor D inhibitor with known potency of inhibiting Factor D activity (e.g., 100% potency). In certain embodiments, the kits further comprise a control sample containing no Factor D inhibitor.

[0487] In certain embodiments, the kits described herein further comprise a quencher. In specific embodiments, the quencher is a Factor D inhibitor (for example, an anti-Factor D antibody or an excess amount of EDTA).

[0488] In specific embodiments, the kits further comprise a recombinantly expressed Factor B. In specific embodiments, the kits further comprise an endogenously expressed Factor B purified from a sample derived from a subject.

[0489] In specific embodiments, the kits further comprise a recombinantly expressed Factor D. In specific embodiments, the kits further comprise an endogenously expressed Factor D purified from a sample derived from a subject.

[0490] The term sample referred to in the kits described herein, can be, but is not limited to, a blood sample or a serum sample.

[0491] The subject referred to in the kits described herein, can be, but is not limited to, a human or non-human vertebrate such as a wild, domestic or farm animal. In certain embodiments, the subject is a mammal, e.g., a human, a cow, a dog, a cat, a goat, a horse, a sheep, a pig, a rat, or a mouse. In a preferred embodiment, the subject is a human.

[0492] The donor/acceptor pair can be any known in the art, or as described in Section 5.1

[0493] The individual components of the kits (e.g., anti-Factor Ba antibody, anti-Factor Bb antibody, first moiety, second moiety, quencher, control) can be packed in one or more containers. In some embodiments, each component is packed in its own container. In some embodiments when the kit comprises anti-Factor Ba antibody and anti-Factor Bb antibody, anti-Factor Ba antibody and the first moiety are packed in one container. In some embodiments when the kit comprises anti-Factor Ba antibody and anti-Factor Bb antibody, anti-Factor Bb antibody and the second moiety are packed in one container. In some embodiments when the kit comprises anti-Factor C3b antibody and anti-Factor Ba antibody, anti-Factor C3b antibody and the first moiety are packed in one container. In some embodiments when the kit comprises anti-Factor C3b antibody and anti-Factor Ba antibody, anti-Factor Ba antibody and the second moiety are packed in one container. The one or more containers can comprise bottle(s), vial(s), tube(s), plate(s), and/or microplate(s). In specific embodiments, the kits further comprise instructions for use of the kits.

6. EXAMPLE

[0494] This following non-limiting example demonstrates that proximity-based measurement assays are desirable methods to measure Factor D activity and Factor D inhibitor potency.

6.1. INTRODUCTION

[0495] Factor D activity has been identified as the key driver in the activation of the alternative complement pathway.

[0496] Lampalizumab is a Fab directed against the complement component Factor D (Katsche et al., 2012, J Biol Chem 287:12886-12892). Factor D is a highly specific chymotrypsin-like serine protease that is a rate-limiting enzyme in the activation of the complement alternative pathway (Katsche et al., 2012, J Biol Chem 287:12886-12892). The substrate for Factor D is another alternative complement pathway serine protease, Factor B. Factor C3b binds to Factor B; then, Factor D cleaves Factor B into Factor Ba and Factor Bb (Volanakis and Narayana, 1996, Protein Sci 5:553-564). Factor Bb remains bound to Factor C3b, forming the active C3 convertase, which initiates the alternative complement pathway. Increased activation of the alternative complement pathway has been found in drusen, cytotoxic deposits present on the Bruch's membrane, which are associated with the development of age-related macular degeneration (AMD) (Damico et al., 2012, Arq Bras Oftalmol 75:71-75).

[0497] Lampalizumab inhibits Factor D-mediated cleavage of Factor B, preventing alternative pathway activation, and thereby inhibiting inflammation and cytotoxic activity of the activated complement components (Tanhehco, 1999, Transplant Proc 31:2168-2171).

[0498] Activation of the alternative complement pathway is typically measured by adding human serum to rabbit erythrocytes. Next, intact erythrocytes and cellular debris are pelleted by centrifugation and lysis is determined by measuring the absorbance at 412 nm arising from the release of hemoglobin into the supernatant.

[0499] An alternative method was developed to measure Factor D enzymatic activity by measuring the cleavage of Factor B using Time Resolved-Frster Energy Resonance Transfer (i.e., fluorescence resonance energy transfer, FRET). The method was used to characterize the activity of a neutralizing Fab fragment directed against Factor D. This assay is simple, homogeneous and shows reproducible dose-response curves in the concentration range of 2 to 125 ng/mL. With interassay variability of less than 5% and recovery of 97-104%, this assay demonstrates acceptable precision and accuracy, and it is able to detect degradative changes in the anti-Factor D Fab fragment samples subjected to oxidative stress, suggesting that it is suitable for use as a potency method in quality control.

[0500] Strategies for assay development and optimization, as well as results from the characterization of the assay are presented below.

6.2. MATERIALS AND METHODS

[0501] 6.2.1. Materials

[0502] The following reagents were used for the FRET study: Lampalizumab, recombinant human Factor D and the anti-Factor Ba and anti-Factor Bb antibodies were generated at Genentech (South San Francisco, Calif.). Complement Factor B and Complement Factor C3b were purchased from Complement Technologies (Tyler, Tex.). Biotinylation of anti-Factor Bb was performed at Genentech using a kit purchased from Pierce (Rockland, Ill.). The Streptavidin-Alexa Fluor 647 and custom conjugation of Complement Factor Ba to Europium were provided by Life Technologies (Grand Island, N.Y.).

[0503] The following reagents were used for the AlphaScreen assay: the anti-Factor B antibodies, Complement Factors B, Factor C3b and Factor D, and the anti-Factor D antibody are as described above. The Streptavidin-coated donor beads and acceptor beads were purchased from Perkin Elmer (Waltham, Mass.).

[0504] The following reagents were used for the hemolysis assay: rabbit erythrocytes were purchased from Colorado Serum (Denver, Colo.). Veronal buffer and Gelatin were purchased from Lonza (Allendale, N.J.). C1q-depleted human serum was purchased from Quidel (San Diego, Calif.).

[0505] 6.2.2. Factor B Cleavage Assay Procedure

[0506] FIG. 1 shows the assay schematic for the Lampalizumab TR-FRET (Time Resolved-FRET) assay. All reagents were prepared in Enzymatic Reaction Buffer (75 mM Sodium Chloride 1 mM Magnesium Chloride, 25 mM Tris, 0.005% Tween 20 pH 7.3). Reference and sample Lampalizumab were titrated. Factor D was diluted to 12.5 ng/mL and Lampalizumab titrations were added 1:1 with the diluted Factor D. Complement Factor B and Complement Factor C3b were diluted to 1 g/mL and 7 g/mL, respectively, and combined 1:1. 50 L per well of the Lampalizumab/Factor D mixture was added to a non-binding 96 well plate from Greiner (Monroe, N.C.) followed by 50 L of the Factor B/Factor C3b mixture and the plate was incubated for 45 minutes with gentle agitation at 25 C. Working concentrations of these reagents were determined by AlphaScreen (data not shown). 50 L of the detection mixture (1.2 g/mL biotinylated anti-Factor Bb, 4.0 nM anti-Factor Ba-Europium and 25 nM Streptavidin-Alexa Fluor 647) was added and the plate was incubated for 1 hour with gentle agitation at 25 C. The Europium and Alexa Fluor647 fluorescence signals were measured on a Paradigm plate reader with an HTRF cartridge (Molecular Devices Sunnyvale, Calif.) with filters appropriate for the excitation of Europium (340 nm) and emission of the Europium and Alexa 647 fluorophores (615 nm and 665 nm, respectively). The TR-FRET ratio was determined by dividing the fluorescence from the Alexa 647 by the fluorescence of the Europium and multiplying by 10,000. The TR-FRET ratio of the Lampalizumab was plotted against the antibody concentrations using a 4 parameter curve-fitting program (Softmax Pro, Molecular Devices, Sunnyvale, Calif.).

[0507] 6.2.3. Hemolysis Assay Procedure

[0508] For determining alternative pathway activity, rabbit erythrocytes (Er) were washed 3 times in Gelatin Veronal Buffer (GVB) (0.1% gelatin in veronal buffer and resuspended to 2109/ml). Lampalizumab (50 l) and 20 l of Er suspension were mixed 1:1 with GVB/0.1M EGTA/0.1M MgCl.sub.2. Complement activation was initiated by the addition of C1q-depleted human serum (Quidel; 30 l diluted 1:3 in GVB). After a 30 minute incubation at room temperature, 200 l GVB/10 mM EDTA were added to stop the reaction and samples were centrifuged for 5 min at 500 g. Hemolysis was quantified in 200 l supernatant by measuring absorbance at 412 nm. Data were expressed as % of hemolysis induced in the absence of the inhibitor.

6.3. RESULTS

[0509] 6.3.1. Optimization of Conditions for Detection of Factor B Cleavage

[0510] In order to optimize the signal of the TR-FRET assay, varying concentrations of the Streptavidin-Alexa-Fluor 647 and anti-Factor Ba-Europium were analyzed with fixed concentrations of the other reagents and then the assay was performed as described in Section 6.1. FIG. 2 shows this co-titration of Streptavidin-Alexa-Fluor 647 and anti-Factor Ba-Europium. Working concentrations of the Streptavidin-Alexa-Fluor 647 and anti-Factor Ba-Europium that provided optimal signal were 4.0 nM anti-Factor Ba-Europium and 25 nM Streptavidin-Alexa Fluor 647, respectively.

[0511] The anti-Factor Ba and anti-Factor Bb detection reagents were tested for their ability to inhibit the cleavage of Factor B by Factor D. FIG. 3 shows that the activity of Factor D was greatly diminished when the detection reagents were added from prior to initiation of the enzymatic reaction (t=0) and increased with increasing time. The small amount of activity seen in the t=0 is likely due to incomplete inactivation of Factor D by anti-Factor Ba and anti-Factor Bb and the extended amount of time required to conduct this experiment. The forty-five minute enzymatic incubation time was determined to provide suitable signal and robust method performance.

[0512] Next, the incubation with detection reagents was optimized. The assay was run as described in Section 6.2, but the incubation with detection reagent was varied from 10-120 minutes. As seen in FIG. 4, a 60 minute detection reagent incubation provided suitable signal and robust method performance.

[0513] To demonstrate that it is possible to use alternate detection reagents to measure cleavage of Factor B, the assay was performed using AlphaScreen reagents. Streptavidin-conjugated alpha donor beads and anti-Factor Ba-conjugated alpha acceptor beads were substituted for TR-FRET reagent. FIGS. 5A and 5B show that both detection technologies generated good signal and dynamic range.

[0514] 6.3.2. Characterization of the anti-Factor D TR-FRET assay

[0515] Using the final assay format, we further characterized the assay by conducting a study for initial evaluation of accuracy and precision. Briefly, anti-Factor D was diluted to nominal concentrations of 0.3, 0.4, 0.5, 0.6 and 0.7 mg/mL, corresponding to 60, 80, 100 and 120 and 140% of the target concentration of 0.5 mg/mL, respectively. The protein concentrations of these dilutions were determined accurately by a UV spectrophotometric scan and determined to be 0.307, 0.381, 0.512, 0.597, 0.722 mg/mL. Each sample was subsequently diluted further into Enzymatic Reaction buffer and tested as described in Section 6.1. Each sample was assayed twelve times (6 times each by 2 different analysts) using new sample and reference dilutions for each assay.

[0516] To assess the accuracy of the assay, the measured activities were divided by the expected activities and expressed as percentage recoveries. Table 10 shows that mean activities of 60, 79, 100, 120 and 139% were obtained. This represents percentage recoveries ranging from 97-104%. Interassay variability, indicated by coefficient of variation (CV) was less than 5%.

[0517] These data strongly suggest that the assay is sensitive to differences in affinity

TABLE-US-00010 TABLE 10 Assessment of the accuracy of the Lampalizumab TR-FRET assay Measure Activity Expected activity (mg/mL) Interassay (mg/mL) Mean +/ SD (n = 12) Accuracy % CV % 0.307 0.300 +/ 0.0102 98 3 0.381 0.395 +/ 0.0096 104 3 0.512 0.500 +/ 0.0154 98 3 0.597 0.600 +/ 0.0259 101 5 0.722 0.695 +/ 0.0260 97 4

[0518] The ability of the Factor B cleavage assay to detect changes in activity of Lampalizumab samples subjected to stress was evaluated. Each sample was tested in 3 assays according to the method described above. The results are summarized in Table 11. Lampalizumab samples subjected to oxidation conditions (30 mM AAPH) exhibited a reduced activity of 63% compared to the control value of 93%.

TABLE-US-00011 TABLE 11 Assessment of the ability of the Lampalizumab TR-FRET assay to detect changes in activity of samples subjected to oxidiation stress TR-FRET Hemolytic Stressed Sample Activity Mean Unstressed control 93 +/ 9 81 +/ 27 Oxidized, 30 mM AAPH 63 +/ 6 82 +/ 16 Thermal Stress 86 (1% diff) 102 +/ 23 Thermal control 103 (0% diff) 96 +/ 18

[0519] The activity of the stress samples was also measured using the rabbit erythrocyte lysis assay to compare the capability of the two methods. The data from this comparison are shown in Table 11 and demonstrate that the Factor B cleavage method is more precise and more sensitive to thermal and oxidative degradation.

6.4. CONCLUSION

[0520] The activity of Lampalizumab is dependent on its ability to bind to Factor D and inhibit its enzymatic activity. This type of activity can be measured in vitro by monitoring rabbit erythrocyte cell lysis after incubation with the Fab fragment. The TR-FRET assay described here measures the ability of Lampalizumab to bind to and inhibit the enzymatic activity of Factor D, the rate-limiting step in activation of the Alternate Complement pathway. To determine whether this method could serve as a suitable measure of Factor D activity, it was assessed for its ability to detect changes in the activity of Lampalizumab that was subjected to oxidative stress, and the data generated by this method were compared to data generated with a more established hemolytic method. The TR-FRET assay is capable of detecting losses in the activity of anti-Factor D subjected to oxidative stress. The results obtained using the TR-FRET assay reveal more sensitivity to stress than the hemolytic method, demonstrating that the TR-FRET assay is a suitable method to measure Factor D activity.

7. INCORPORATION BY REFERENCE

[0521] Various references such as patents, patent applications, and publications are cited herein, the disclosures of which are hereby incorporated by reference herein in their entireties.