Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases

Abstract

Disclosed herein are novel benzoimidazoles and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain novel benzoimidazoles that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Claims

1. A compound selected from: ##STR00444## or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

3. A method for treating hyperproliferative disorders responsive to inhibition of IDO and/or TDO comprising administering to a subject in recognized need thereof a compound of claim 1, or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit said IDO and/or TDO.

4. The method according to claim 3, wherein the hyperproliferative disorder is cancer.

5. The method according to claim 3, wherein the hyperproliferative disorder is selected from melanomas, thyroid cancer, Barret's adenocarcinoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, lung cancer, renal carcinoma, head and neck cancer, liver cancer, stomach cancer, esophageal cancer, ovarian cancer, pancreatic cancer, prostate cancer, hematologic cancers, cancer of biliary tract, non-small cell lung cancer, endometrium cancer, blood cancer, large intestinal colon carcinoma, histiocytic lymphoma, or lung adenocarcinoma.

6. A method for treating or preventing HIV infection/AIDS comprising administering to a subject in recognized need thereof therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

7. A method for enhancing the effectiveness of an anti-retroviral therapy comprising administering to a subject in recognized need thereof therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) As used herein, the following words, phrases and symbols are generally intended to have the meanings as set forth below, except to the extent that the context in which they are used indicates otherwise.

(2) The following abbreviations and terms have the indicated meanings throughout:

(3) The phrase “a” or “an” entity as used herein refers to one or more of that entity. For example, a compound refers to one or more compounds or at least one compound. For another example, “ . . . substituted with a substituent . . . ” means that one or more substituents are substituted as long as valence and stability permit. As such, the terms “a” (or “an”), “one or more”, and “at least one” can be used interchangeably herein.

(4) The term “alkyl” herein refers to a hydrocarbon group selected from linear and branched saturated hydrocarbon groups comprising from 1 to 18, such as from 1 to 12, further such as from 1 to 10, more further such as from 1 to 8, or from 1 to 6, or from 1 to 4, carbon atoms. Examples of alkyl groups comprising from 1 to 6 carbon atoms (i.e., C.sub.1-6 alkyl) include, but not limited to methyl, ethyl, 1-propyl or n-propyl (“n-Pr”), 2-propyl or isopropyl (“i-Pr”), 1-butyl or n-butyl (“n-Bu”), 2-methyl-1-propyl or isobutyl (“i-Bu”), 1-methylpropyl or s-butyl (“s-Bu”), 1,1-dimethylethyl or t-butyl (“t-Bu”), 1-pentyl, 2-pentyl, 3-pentyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 3-methyl-1-butyl, 2-methyl-1-butyl, 1-hexyl, 2-hexyl, 3-hexyl, 2-methyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 3-methyl-3-pentyl, 2-methyl-3-pentyl, 2,3-dimethyl-2-butyl and 3,3-dimethyl-2-butyl groups.

(5) The term “alkyloxy” herein refers to an alkyl group as defined above bonded to oxygen, represented by —Oalkyl. Examples of an alkyloxy, e.g., C.sub.1-6 alkyloxy or C.sub.1-4 alkyloxy includes, but not limited to, methoxy, ethoxyl, isopropoxy, propoxy, n-butoxy, tert-butoxy, pentoxy and hexoxy and the like.

(6) The term “haloalkyl” herein refers to an alkyl group in which one or more hydrogen is/are replaced by one or more halogen atoms such as fluoro, chloro, bromo, and iodo. Examples of the haloalkyl include C.sub.1-6haloalkyl or C.sub.1-4haloalkyl, but not limited to F.sub.3C—, ClCH.sub.2—, CF.sub.3CH.sub.2—, CF.sub.3CCl.sub.2—, and the like.

(7) The term “alkenyl” herein refers to a hydrocarbon group selected from linear and branched hydrocarbon groups comprising at least one C═C double bond and from 2 to 18, such as from 2 to 8, further such as from 2 to 6, carbon atoms. Examples of the alkenyl group, e.g., C.sub.2-6 alkenyl, include, but not limited to ethenyl or vinyl, prop-1-enyl, prop-2-enyl, 2-methylprop-1-enyl, but-1-enyl, but-2-enyl, but-3-enyl, buta-1,3-dienyl, 2-methylbuta-1,3-dienyl, hex-1-enyl, hex-2-enyl, hex-3-enyl, hex-4-enyl, and hexa-1,3-dienyl groups.

(8) The term “alkynyl” herein refers to a hydrocarbon group selected from linear and branched hydrocarbon group, comprising at least one C≡C triple bond and from 2 to 18, such as 2 to 8, further such as from 2 to 6, carbon atoms. Examples of the alkynyl group, e.g., C.sub.2-6 alkynyl, include, but not limited to ethynyl, 1-propynyl, 2-propynyl (propargyl), 1-butynyl, 2-butynyl, and 3-butynyl groups.

(9) The term “cycloalkyl” herein refers to a hydrocarbon group selected from saturated and partially unsaturated cyclic hydrocarbon groups, comprising monocyclic and polycyclic (e.g., bicyclic and tricyclic) groups. For example, the cycloalkyl group may comprise from 3 to 12, such as from 3 to 10, further such as 3 to 8, further such as 3 to 6, 3 to 5, or 3 to 4 carbon atoms. Even further for example, the cycloalkyl group may be selected from monocyclic group comprising from 3 to 12, such as from 3 to 10, further such as 3 to 8, 3 to 6 carbon atoms. Examples of the monocyclic cycloalkyl group include cyclopropyl, cyclobutyl, cyclopentyl, 1-cyclopent-1-enyl, 1-cyclopent-2-enyl, 1-cyclopent-3-enyl, cyclohexyl, 1-cyclohex-1-enyl, 1-cyclohex-2-enyl, 1-cyclohex-3-enyl, cyclohexadienyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, cycloundecyl, and cyclododecyl groups. In particular, Examples of the saturated monocyclic cycloalkyl group, e.g., C.sub.3-8 cycloalkyl, include, but not limited to cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl groups. Examples of the bicyclic cycloalkyl groups include those having from 7 to 12 ring atoms arranged as a bicyclic ring selected from [4,4], [4,5], [5,5], [5,6] and [6,6] ring systems, or as a bridged bicyclic ring selected from bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, and bicyclo[3.2.2]nonane. Further Examples of the bicyclic cycloalkyl groups include those arranged as a bicyclic ring selected from [5,6] and [6,6] ring systems, such as

(10) ##STR00002##
wherein the wavy lines indicate the points of attachment. The ring may be saturated or have at least one double bond (i.e. partially unsaturated), but is not fully conjugated, and is not aromatic, as aromatic is defined herein.

(11) The term “aryl” used alone or in combination with other terms refers to a group selected from:

(12) 5- and 6-membered carbocyclic aromatic rings, for example, phenyl;

(13) bicyclic ring systems such as 7 to 12 membered bicyclic ring systems wherein at least one ring is carbocyclic and aromatic, selected, for example, from naphthalene, and indane; and

(14) tricyclic ring systems such as 10 to 15 membered tricyclic ring systems wherein at least one ring is carbocyclic and aromatic, for example, fluorene.

(15) The terms “aromatic hydrocarbon ring” and “aryl” are used interchangeable throughout the disclosure herein. In some embodiments, a monocyclic or bicyclic aromatic hydrocarbon ring has 5 to 10 ring-forming carbon atoms (i.e., C.sub.5-10 aryl). Examples of a monocyclic or bicyclic aromatic hydrocarbon ring includes, for example, but not limited to, phenyl, naphth-1-yl, naphth-2-yl, anthracenyl, phenanthrenyl rings, and the like. In some embodiments, the aromatic hydrocarbon ring is a naphthalene ring (naphth-1-yl or naphth-2-yl) or phenyl ring. In some embodiments, the aromatic hydrocarbon ring is a phenyl ring.

(16) The term “halogen” or “halo” herein refers to F, Cl, Br or I.

(17) The term “heteroaryl” herein refers to a group selected from:

(18) 5- to 7-membered aromatic, monocyclic rings comprising at least one heteroatom, for example, from 1 to 4, or, in some embodiments, from 1 to 3, heteroatoms, selected from N, O, and S, with the remaining ring atoms being carbon;

(19) 8- to 12-membered bicyclic rings comprising at least one heteroatom, for example, from 1 to 4, or, in some embodiments, from 1 to 3, or, in other embodiments, 1 or 2, heteroatoms, selected from N, O, and S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in the aromatic ring; and

(20) 11- to 14-membered tricyclic rings comprising at least one heteroatom, for example, from 1 to 4, or in some embodiments, from 1 to 3, or, in other embodiments, 1 or 2, heteroatoms, selected from N, O, and S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in an aromatic ring.

(21) When the total number of S and O atoms in the heteroaryl group exceeds 1, those heteroatoms are not adjacent to one another. In some embodiments, the total number of S and O atoms in the heteroaryl group is not more than 2. In some embodiments, the total number of S and O atoms in the aromatic heterocycle is not more than 1. When the heteroaryl group contains more than one heteroatom ring member, the heteroatoms may be the same or different. The nitrogen atoms in the ring(s) of the heteroaryl group can be oxidized to form N-oxides.

(22) The terms “aromatic heterocyclic ring” and “heteroaryl” are used interchangeable throughout the disclosure herein. In some embodiments, a monocyclic or bicyclic aromatic heterocyclic ring has 5- to 10-ring forming members with 1, 2, 3, or 4 heteroatom ring members independently selected from nitrogen, sulfur and oxygen and the remaining ring members being carbon. In some embodiments, the monocyclic or bicyclic aromatic heterocyclic ring is a monocyclic or bicyclic ring comprising 1 or 2 heteroatom ring members independently selected from nitrogen, sulfur and oxygen. In some embodiments, the monocyclic or bicyclic aromatic heterocyclic ring is a 5- to 6-membered heteroaryl ring, which is monocyclic and which has 1 or 2 heteroatom ring members independently selected from nitrogen, sulfur and oxygen. In some embodiments, the monocyclic or bicyclic aromatic heterocyclic ring is a 8- to 10-membered heteroaryl ring, which is bicyclic and which has 1 or 2 heteroatom ring members independently selected from nitrogen, sulfur and oxygen.

(23) Examples of the heteroaryl group or the monocyclic or bicyclic aromatic heterocyclic ring include, but are not limited to, (as numbered from the linkage position assigned priority 1) pyridyl (such as 2-pyridyl, 3-pyridyl, or 4-pyridyl), cinnolinyl, pyrazinyl, 2,4-pyrimidinyl, 3,5-pyrimidinyl, 2,4-imidazolyl, imidazopyridinyl, isoxazolyl, oxazolyl, thiazolyl, isothiazolyl, thiadiazolyl (such as 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, or 1,3,4-thiadiazolyl), tetrazolyl, thienyl (such as thien-2-yl, thien-3-yl), triazinyl, benzothienyl, furyl or furanyl, benzofuryl, benzoimidazolyl, indolyl, isoindolyl, indolinyl, oxadiazolyl (such as 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, or 1,3,4-oxadiazolyl), phthalazinyl, pyrazinyl, pyridazinyl, pyrrolyl, triazolyl (such as 1,2,3-triazolyl, 1,2,4-triazolyl, or 1,3,4-triazolyl), quinolinyl, isoquinolinyl, pyrazolyl, pyrrolopyridinyl (such as 1H-pyrrolo[2,3-b]pyridin-5-yl), pyrazolopyridinyl (such as 1H-pyrazolo[3,4-b]pyridin-5-yl), benzoxazolyl (such as benzo[d]oxazol-6-yl), pteridinyl, purinyl, 1-oxa-2,3-diazolyl, 1-oxa-2,4-diazolyl, 1-oxa-2,5-diazolyl, 1-oxa-3,4-diazolyl, 1-thia-2,3-diazolyl, 1-thia-2,4-diazolyl, 1-thia-2,5-diazolyl, 1-thia-3,4-diazolyl, furazanyl (such as furazan-2-yl, furazan-3-yl), benzofurazanyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinazolinyl, quinoxalinyl, naphthyridinyl, furopyridinyl, benzothiazolyl (such as benzo[d]thiazol-6-yl), indazolyl (such as 1H-indazol-5-yl) and 5,6,7,8-tetrahydroisoquinoline.

(24) The term “heterocyclic” or “heterocycle” or “heterocyclyl” herein refers to a ring selected from 4- to 12-membered monocyclic, bicyclic and tricyclic, saturated and partially unsaturated rings comprising at least one carbon atoms in addition to at least one heteroatom, such as from 1-4 heteroatoms, further such as from 1-3, or further such as 1 or 2 heteroatoms, selected from oxygen, sulfur, and nitrogen. In some embodiments, a heterocyclyl group is 4- to 7-membered monocyclic ring with one heteroatom selected from N, O and S. “Heterocycle” herein also refers to a 5- to 7-membered heterocyclic ring comprising at least one heteroatom selected from N, O, and S fused with 5-, 6-, and/or 7-membered cycloalkyl, carbocyclic aromatic or heteroaromatic ring, provided that the point of attachment is at the heterocyclic ring when the heterocyclic ring is fused with a carbocyclic aromatic or a heteroaromatic ring, and that the point of attachment can be at the cycloalkyl or heterocyclic ring when the heterocyclic ring is fused with cycloalkyl. “Heterocycle” herein also refers to an aliphatic spirocyclic ring comprising at least one heteroatom selected from N, O, and S, provided that the point of attachment is at the heterocyclic ring. The rings may be saturated or have at least one double bond (i.e. partially unsaturated). The heterocycle may be substituted with oxo. The point of the attachment may be carbon or heteroatom in the heterocyclic ring. A heterocycle is not a heteroaryl as defined herein.

(25) Examples of the heterocycle include, but not limited to, (as numbered from the linkage position assigned priority 1) 1-pyrrolidinyl, 2-pyrrolidinyl, 2,4-imidazolidinyl, 2,3-pyrazolidinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 2,5-piperazinyl, pyranyl, 2-morpholinyl, 3-morpholinyl, oxiranyl, aziridinyl, thiiranyl, azetidinyl, oxetanyl, thietanyl, 1,2-dithietanyl, 1,3-dithietanyl, dihydropyridinyl, tetrahydropyridinyl, thiomorpholinyl, thioxanyl, piperazinyl, homopiperazinyl, homopiperidinyl, azepanyl, oxepanyl, thiepanyl, 1,4-oxathianyl, 1,4-dioxepanyl, 1,4-oxathiepanyl, 1,4-oxaazepanyl, 1,4-dithiepanyl, 1,4-thiazepanyl and 1,4-diazepane 1,4-dithianyl, 1,4-azathianyl, oxazepinyl, diazepinyl, thiazepinyl, dihydrothienyl, dihydropyranyl, dihydrofuranyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydropyranyl, tetrahydrothiopyranyl, 1-pyrrolinyl, 2-pyrrolinyl, 3-pyrrolinyl, indolinyl, 2H-pyranyl, 4H-pyranyl, 1,4-dioxanyl, 1,3-dioxolanyl, pyrazolinyl, pyrazolidinyl, dithianyl, dithiolanyl, pyrazolidinyl, imidazolinyl, pyrimidinonyl, 1,1-dioxo-thiomorpholinyl, 3-azabicyco[3.1.0]hexanyl, 3-azabicyclo[4.1.0]heptanyl and azabicyclo[2.2.2]hexanyl. A substituted heterocycle also includes a ring system substituted with one or more oxo moieties, such as piperidinyl N-oxide, morpholinyl-N-oxide, 1-oxo-1-thiomorpholinyl and 1,1-dioxo-1-thiomorpholinyl.

(26) The term “fused ring” herein refers to a polycyclic ring system, e.g., a bicyclic or tricyclic ring system, in which two rings share only two ring atoms and one bond in common. Examples of fused rings may comprise a fused bicyclic cycloalkyl ring such as those having from 7 to 12 ring atoms arranged as a bicyclic ring selected from [4,4], [4,5], [5,5], [5,6] and [6,6] ring systems as mentioned above; a fused bicyclic aryl ring such as 7 to 12 membered bicyclic aryl ring systems as mentioned above, a fused tricyclic aryl ring such as 10 to 15 membered tricyclic aryl ring systems mentioned above; a fused bicyclic heteroaryl ring such as 8- to 12-membered bicyclic heteroaryl rings as mentioned above, a fused tricyclic heteroaryl ring such as 11- to 14-membered tricyclic heteroaryl rings as mentioned above; and a fused bicyclic or tricyclic heterocyclyl ring as mentioned above.

(27) Compounds disclosed herein may contain an asymmetric center and may thus exist as enantiomers. Where the compounds disclosed herein possess two or more asymmetric centers, they may additionally exist as diastereomers. Enantiomers and diastereomers fall within the broader class of stereoisomers. All such possible stereoisomers as substantially pure resolved enantiomers, racemic mixtures thereof, as well as mixtures of diastereomers are intended to be included. All stereoisomers of the compounds disclosed herein and/or pharmaceutically acceptable salts thereof are intended to be included. Unless specifically mentioned otherwise, reference to one isomer applies to any of the possible isomers. Whenever the isomeric composition is unspecified, all possible isomers are included.

(28) The term “substantially pure” as used herein means that the target stereoisomer contains no more than 35%, such as no more than 30%, further such as no more than 25%, even further such as no more than 20%, by weight of any other stereoisomer(s). In some embodiments, the term “substantially pure” means that the target stereoisomer contains no more than 10%, for example, no more than 5%, such as no more than 1%, by weight of any other stereoisomer(s).

(29) When compounds disclosed herein contain olefinic double bonds, unless specified otherwise, such double bonds are meant to include both E and Z geometric isomers.

(30) Some of the compounds disclosed herein may exist with different points of attachment of hydrogen, referred to as tautomers. For example, compounds including carbonyl —CH.sub.2C(O)— groups (keto forms) may undergo tautomerism to form hydroxyl —CH═C(OH)— groups (enol forms). Both keto and enol forms, individually as well as mixtures thereof, are also intended to be included where applicable.

(31) It may be advantageous to separate reaction products from one another and/or from starting materials. The desired products of each step or series of steps is separated and/or purified (hereinafter separated) to the desired degree of homogeneity by the techniques common in the art. Typically such separations involve multiphase extraction, crystallization from a solvent or solvent mixture, distillation, sublimation, or chromatography. Chromatography can involve any number of methods including, for example: reverse-phase and normal phase; size exclusion; ion exchange; high, medium and low pressure liquid chromatography methods and apparatus; small scale analytical; simulated moving bed (“SMB”) and preparative thin or thick layer chromatography, as well as techniques of small scale thin layer and flash chromatography. One skilled in the art will apply techniques most likely to achieve the desired separation.

(32) Diastereomeric mixtures can be separated into their individual diastereomers on the basis of their physical chemical differences by methods well known to those skilled in the art, such as by chromatography and/or fractional crystallization. Enantiomers can be separated by converting the enantiomeric mixture into a diastereomeric mixture by reaction with an appropriate optically active compound (e.g., chiral auxiliary such as a chiral alcohol or MosheR.sup.as acid chloride), separating the diastereomers and converting (e.g., hydrolyzing) the individual diastereoisomers to the corresponding pure enantiomers. Enantiomers can also be separated by use of a chiral HPLC column.

(33) A single stereoisomer, e.g., a substantially pure enantiomer, may be obtained by resolution of the racemic mixture using a method such as formation of diastereomers using optically active resolving agents (Eliel, E. and Wilen, S. Stereochemistry of Organic Compounds. New York: John Wiley & Sons, Inc., 1994; Lochmuller, C. H., et al. “Chromatographic resolution of enantiomers: Selective review.” J. Chromatogr., 113(3) (1975): pp. 283-302). Racemic mixtures of chiral compounds of the invention can be separated and isolated by any suitable method, including: (1) formation of ionic, diastereomeric salts with chiral compounds and separation by fractional crystallization or other methods, (2) formation of diastereomeric compounds with chiral derivatizing reagents, separation of the diastereomers, and conversion to the pure stereoisomers, and (3) separation of the substantially pure or enriched stereoisomers directly under chiral conditions. See: Wainer, Irving W., Ed. Drug Stereochemistry: Analytical Methods and Pharmacology. New York: Marcel Dekker, Inc., 1993.

(34) “Pharmaceutically acceptable salts” refers to those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like, and are commensurate with a reasonable benefit/risk ratio. A pharmaceutically acceptable salt may be prepared in situ during the final isolation and purification of the compounds disclosed herein, or separately by reacting the free base function with a suitable organic acid or by reacting the acidic group with a suitable base.

(35) In addition, if a compound disclosed herein is obtained as an acid addition salt, the free base can be obtained by basifying a solution of the acid salt. Conversely, if the product is a free base, an addition salt, such as a pharmaceutically acceptable addition salt, may be produced by dissolving the free base in a suitable organic solvent and treating the solution with an acid, in accordance with conventional procedures for preparing acid addition salts from base compounds. Those skilled in the art will recognize various synthetic methodologies that may be used without undue experimentation to prepare non-toxic pharmaceutically acceptable addition salts.

(36) As defined herein, “a pharmaceutically acceptable salt thereof” include salts of at least one compound of Formula (I), and salts of the stereoisomers of at least one compound of Formula (I), such as salts of enantiomers, and/or salts of diastereomers.

(37) “Treating”, “treat” or “treatment” or “alleviation” refers to administering at least one compound and/or at least one stereoisomer thereof, and/or at least one pharmaceutically acceptable salt thereof disclosed herein to a subject in recognized need thereof that has, for example, cancer.

(38) The term “effective amount” refers to an amount of at least one compound and/or at least one stereoisomer thereof, and/or at least one pharmaceutically acceptable salt thereof disclosed herein effective to “treat” as defined above, a disease or disorder in a subject.

(39) The term “at least one substituent” disclosed herein includes, for example, from 1 to 4, such as from 1 to 3, further as 1 or 2, substituents, provided that valence and stability permit. For example, “at least one substituent R.sup.7” disclosed herein includes from 1 to 4, such as from 1 to 3, further as 1 or 2, substituents selected from the list of R.sup.7 as disclosed herein; and “at least one substituent R.sup.10” disclosed herein includes from 1 to 4, such as from 1 to 3, further as 1 or 2, substituents selected from the list of R.sup.10 as disclosed herein.

(40) In the first aspect, disclosed herein is a compound of Formula (I):

(41) ##STR00003##
or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof,
wherein:

(42) M is CH or N;

(43) W is CH or N;

(44) p is 1, 2 or 3;

(45) q is 0, 1 or 2;

(46) X is —CR.sup.5R.sup.6—, —CHR.sup.5CHR.sup.6— or a single bond;

(47) Y and Z are each independently hydrogen, halogen, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-8 haloalkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, or heteroaryl; or Z and Y, together with the atoms to which they are attached, form a bridged cyclic or heterocyclic ring optionally substituted with a substituent selected from halogen, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl and C.sub.1-4alkoxy;

(48) Ring A is a monocyclic or bicyclic aromatic hydrocarbon ring or a monocyclic or bicyclic aromatic heterocyclic ring, each having 5- to 10-ring members; and Ring A is optionally substituted with at least one substituent R.sup.7;

(49) R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, halogen, cyano, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, heterocyclyl, aryl, heteroaryl, —C(O)NR.sup.8R.sup.9, nitro, —C(O)OR.sup.8, —C(O)R.sup.8, —OR.sup.8, —SR.sup.8, —NR.sup.8R.sup.9, —SO.sub.2R.sup.8, —SO.sub.2NR.sup.8R.sup.9, —SOR.sup.8, —NR.sup.8SO.sub.2R.sup.9, —NR.sup.8SOR.sup.9, —NR.sup.8C(O)OR.sup.9 or —NR.sup.8C(O)R.sup.9, wherein said C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-8 haloalkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently optionally substituted with 1 or 2 substituent R.sup.10; or (R.sup.1 and R.sup.2) or (R.sup.2 and R.sup.3) or (R.sup.3 and R.sup.4), together with the atoms to which they are attached, form a heterocyclyl ring or a heteroaryl ring, said ring comprising 0, 1 or 2 heteroatoms independently selected from —NH, —O—, —S—, —SO— or —SO.sub.2—, and said ring is optionally substituted with halogen, oxo, C.sub.1-4 haloalkyl and C.sub.1-4 alkyl;

(50) R.sup.5 and R.sup.6 are each independently hydrogen, halogen, cyano, C.sub.1-4alkyl, C.sub.1-4haloalkyl, C.sub.1-4 alkoxy, or C.sub.3-6cycloalkyl; or (R.sup.5 and R.sup.6), and/or (R.sup.5 and Y), together with the atoms to which they are attached, form a fused cyclopropyl ring;

(51) R.sup.7 is independently hydrogen, halogen, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-8 haloalkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein said C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-8 haloalkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently optionally substituted with 1 or 2 substituent R.sup.10;

(52) R.sup.8 and R.sup.9 are each independently hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein said C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently optionally substituted with 1 or 2 substituent R.sup.10; or R.sup.8 and R.sup.9, together with the atoms to which they are attached, form a 3- to 8-membered saturated or partially or fully unsaturated ring comprising 0, 1 or 2 additional heteroatoms independently selected from —NH, —O—, —S—, —SO— or —SO.sub.2—, and said ring is optionally substituted with at least one substituent R.sup.10;

(53) R.sup.10, at each occurrence, is independently hydrogen, halogen, C.sub.1-8 haloalkyl, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl, C.sub.2-8 alkynyl, oxo, —C.sub.1-4 alkyl-NR.sup.aR.sup.b, —CN, —OR, —NR.sup.aR.sup.b, —C(O)R.sup.a, —C(O)OR.sup.a, —CONR.sup.aR.sup.b, —C(═NR.sup.a)NR.sup.bR.sup.c, nitro, —NR.sup.aC(O)R.sup.b, —NR.sup.aC(O)NR.sup.aR.sup.b, —NR.sup.aC(O)OR.sup.b, —SO.sub.2R.sup.a, —NR.sup.aSO.sub.2NR.sup.bR.sup.c, —NR.sup.aSOR.sup.b or —NR.sup.aSO.sub.2R.sup.b, wherein said C.sub.1-8 alkyl, C.sub.1-8 haloalkyl, C.sub.3-8 cycloalkyl, aryl, heteroaryl, or heterocyclyl group are each independently optionally substituted by one, two or three substituents selected from halo, hydroxyl, C.sub.1-4 alkyl and C.sub.1-4 haloalkyl, wherein R.sup.a, R.sup.b, and R.sup.c are each independently selected from H, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, heterocyclyl, aryl, and heteroaryl, each of which is optionally substituted by one or more halogen, C.sub.1-4 haloalkyl and C.sub.1-4 alkyl, or (R.sup.a and R.sup.b), and/or (R.sup.b and R.sup.c) together with the atoms to which they are attached, form a ring selected from a heterocyclyl or heteroaryl ring optionally substituted by halogen, C.sub.1-4 haloalkyl or C.sub.1-4 alkyl.

(54) In one embodiment of the first aspect, p is 1, and q is 1. In another embodiment, p is 1 and q is 0. In one embodiment of the first aspect, W is N and M is CH. In another embodiment, W and M are both N. In further another embodiment, W and M are both CH. In yet further embodiment, W is CH and M is N.

(55) Preferably, the

(56) ##STR00004##
moiety is

(57) ##STR00005##
wherein * indicates a link to the ring A, and ** indicates a link to X.

(58) In one embodiment, X is —CR.sup.5R.sup.6—, wherein R.sup.5 is C.sub.1-4alkyl, C.sub.1-4haloalkyl, C.sub.1-4alkoxy, or C.sub.3-6-cycloalkyl, and R.sup.6 is hydrogen. In another embodiment, X is —CR.sup.5R.sup.6—, wherein R is C.sub.1-4alkyl, C.sub.1-4haloalkyl, C.sub.1-4alkoxy, or C.sub.3-6cycloalkyl, and R.sup.6 is hydrogen, and the

(59) ##STR00006##
moiety is

(60) ##STR00007##
wherein * indicates a link to the ring A, and ** indicates a link to X. In a further preferred embodiment, R.sup.5 is methyl, trifluoromethyl, methoxy, or cyclopropyl, and R.sup.6 is hydrogen. Specifically, the compound of Formula (I) is a compound selected from benzoimidazoles of Formulas (Ia) and/or (Ib):

(61) ##STR00008##
wherein the variables R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Z, Y and A are defined as for Formula (I).

(62) In one embodiment, Z and Y, together with the atoms to which they are attached, form a bridged bicyclic ring optionally substituted with a substituent selected from halogen, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl and C.sub.1-4alkoxy. Preferably, Z and Y, together with the atoms to which they are attached, form a bridged bicyclic ring selected from bicyclo[2.2.1]heptyl (e.g., bicyclo[2.2.1]heptan-2-yl), born-2-yl, bicyclo[2.2.2]octyl, bicyclo[3.2.1]octyl, bicyclo[3.3.1]nonyl, or bicyclo[3.3.2.]decyl. More preferably, the bridged bicyclic ring is bicyclo[2.2.1]heptyl or bicyclo[2.2.2]octyl.

(63) In one embodiment, R and R.sup.4 are each independently hydrogen, halogen, C.sub.1-8 alkyl, —C(O)NR.sup.8R.sup.9, COOR.sup.8, or NR.sup.8R.sup.9; preferably H, halogen, or C.sub.1-8 alkyl; more preferably, H, F, or methyl.

(64) In one embodiment, R.sup.2 and R.sup.3 are each independently hydrogen, halogen, cyano, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(O)OR.sup.8; —C(O)NR.sup.8R.sup.9, —OR.sup.8, —NR.sup.8R.sup.9, —NR.sup.8SO.sub.2R.sup.9, —SO.sub.2R.sup.8, —SO.sub.2NR.sup.8R.sup.9, or —COR.sup.8, wherein said C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently optionally substituted with 1 or 2 substituent R.sup.10, and wherein R.sup.8 and R.sup.9 are each independently hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein said C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently optionally substituted with 1 or 2 substituent R.sup.10, wherein R.sup.10 is defined as in Formula (I).

(65) Preferably, R.sup.2 and R.sup.3 are each independently hydrogen, halogen (preferably F, Cl, Br), cyano, C.sub.1-8 alkyl (preferably methyl, ethyl, propyl, isopropyl, butyl, t-butyl), C.sub.3-8 cycloalkyl (preferably cyclopropyl), heterocyclyl (e.g., piperidinyl), aryl, heteroaryl (preferably oxazolyl (e.g., oxazol-5-yl), oxadiazolyl (e.g., 1,2,4-oxadiazol-3-yl), pyrazolyl (e.g., 1H-pyrazol-1-yl), pyridinyl (e.g., pyridin-3-yl, pyridin-4-yl), pyrimidinyl (e.g., pyrimidin-2-yl)), —C(O)OR.sup.8 (wherein R.sup.8 is H, C.sub.1-8 alkyl, such as methyl, ethyl, propyl, isopropyl, t-butyl; or C.sub.3-8cycloalkyl, such as cyclopropyl); —C(O)NR.sup.8R.sup.9, —OR.sup.8 (wherein R.sup.8 is C.sub.1-8alkyl, or C.sub.3-8cycloalkyl (preferably cyclopropyl)), —NR.sup.8SO.sub.2R (wherein R.sup.8 and R.sup.9 are each H or C.sub.1-8 alkyl), —NR.sup.8R.sup.9 (wherein R.sup.8 and R.sup.9 are each hydrogen or C.sub.1-8 alkyl), —SO.sub.2R.sup.8 (wherein R.sup.8 is C.sub.1-8 alkyl), —SO.sub.2NR.sup.8R.sup.9 (wherein R.sup.8 and R.sup.9 are each H or C.sub.1-8alkyl), or —COR.sup.8 (wherein R is H or C.sub.1-8alkyl), wherein said C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, and heteroaryl in R.sup.2 or R.sup.3 are each independently optionally substituted with 1 or 2 substituent R.sup.10 and said C.sub.1-8alkyl or C.sub.3-8cycloalkyl in R.sup.8 or R.sup.9 are each independently optionally substituted with 1 or 2 substituent R.sup.10.

(66) Preferably, one of R.sup.2 and R.sup.3 is —C(O)NR.sup.8R.sup.9, wherein R.sup.8 and R.sup.9 are each independently H, C.sub.1-8 alkyl (more preferably methyl, ethyl), C.sub.3-8cycloalkyl (more preferably cyclopropyl, cyclobutyl, cyclohexyl), or aryl (e.g., phenyl), said C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, or aryl are each independently optionally substituted with 1 or 2 substituent R.sup.10, or R.sup.8 and R.sup.9, together with the nitrogen atom to which they are attached, form a 3-, 4-, 5-, or 6-membered saturated ring comprising 0 additional heteroatom, and said ring is optionally substituted with at least one substituent R.sup.10; preferably, R and R.sup.9, together with the nitrogen atom to which they are attached, form azetidin-1-yl, azetidin-1-yl, pyrrolidin-1-yl, or piperidin-1-yl).

(67) In one embodiment, R.sup.2 and R.sup.3, together with the atoms to which they are attached, form a heterocyclyl ring comprising two oxygen atoms. Preferably, R.sup.2 and R.sup.3, together with the atoms to which they are attached, form a 5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazole ring.

(68) In one embodiment, R.sup.2 and R.sup.3, together with the atoms to which they are attached, form a heterocyclyl ring, said ring comprising zero or two nitrogen atoms. Preferably, R.sup.2 and R.sup.3, together with the atoms to which they are attached, form a imidazo[4,5-g]quinazoline ring (optionally substituted with oxo, e.g., to form a 3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one group) or a imidazo[4,5-g]quinoline ring (optionally substituted with oxo, e.g., to form a 7,8-dihydro-3H-imidazo[4,5-g]quinolin-6(5H)-one group), or a 1H-naphtho[2,3-d]imidazole ring.

(69) In one embodiment, R.sup.1 and R.sup.2, together with the atoms to which they are attached, form a heteroaryl ring, said ring comprising one nitrogen atoms. Preferably, R.sup.1 and R.sup.2, together with the atoms to which they are attached, form a 3H-imidazo[4,5-f]quinoline.

(70) In one embodiment, R.sup.3 and R.sup.4, together with the atoms to which they are attached, form a heteroaryl ring, said ring comprising zero or one nitrogen atoms. Preferably, R.sup.3 and R.sup.4, together with the atoms to which they are attached, form a 1H-naphtho[2,1-d]imidazole ring.

(71) In some embodiment, ring A is phenyl or naphthalenyl ring. In some embodiment, ring A is a monocyclic or bicyclic aromatic heterocyclic ring having 5- to 10-ring members comprising 1, 2, 3, or 4 heteroatoms selected from O, S, and N.

(72) In some embodiment, ring A is a monocyclic aromatic heterocyclic ring having 5- to 6-ring members comprising 1 or 2 heteroatoms selected from O, S, and N. In other embodiments, ring A is pyridinyl, furanyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, thienyl, triazinyl, or pyrazolyl. In some preferred embodiments, ring A is pyridinyl or furanyl.

(73) In some embodiment, ring A is a bicyclic aromatic heterocyclic ring having 8- to 10-ring members comprising 1 or 2 or 3 heteroatoms selected from O, S, and N. In another embodiment, ring A is cinnolinyl, benzothienyl, benzofuryl, benzoimidazolyl, indolyl, isoindolyl, indolinyl, phthalazinyl, quinolinyl, isoquinolinyl, pyrrolopyridinyl, pyrazolopyridinyl, benzodioxolyl, benzoxazolyl, pteridinyl, purinyl, benzofurazanyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinazolinyl, quinoxalinyl, naphthyridinyl, furopyridinyl, benzothiazolyl, or indazolyl. In some preferred embodiments, ring A is benzothiophenyl (such as benzo[b]thiophen-2-yl, benzo[b]thiophen-3-yl, benzo[b]thiophen-5-yl, or benzo[b]thiophen-6-yl) or quinolinyl (such as quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl) or benzodioxolyl (such as benzo[d][1,3]dioxol-5-yl).

(74) In one embodiment, ring A is optionally substituted with one substituent R.sup.7 which is independently hydrogen, halogen, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-8 haloalkyl, C.sub.3-8 cycloalkyl, heterocyclyl, aryl, or heteroaryl.

(75) In one preferred embodiment, ring A is quinolinyl (such as quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl) optionally substituted with halogen or C.sub.1-8haloalkyl. More preferably, ring A is 6-fluoroquinolin-4-yl or 8-fluoro-quinolin-5-yl.

(76) In one embodiment, the compound disclosed herein has one of the following configurations:

(77) ##STR00009##
wherein R.sup.5 is C.sub.1-4alkyl, C.sub.1-4haloalkyl, C.sub.1-4alkoxy, or C.sub.3-6cycloalkyl; R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.7 are defined as for Formula (I).

(78) Also disclosed herein is a compound selected from the group consisting of:

(79) ##STR00010## ##STR00011## ##STR00012## ##STR00013## ##STR00014## ##STR00015## ##STR00016## ##STR00017## ##STR00018## ##STR00019## ##STR00020## ##STR00021## ##STR00022## ##STR00023## ##STR00024## ##STR00025## ##STR00026## ##STR00027## ##STR00028## ##STR00029## ##STR00030## ##STR00031## ##STR00032## ##STR00033## ##STR00034## ##STR00035## ##STR00036## ##STR00037## ##STR00038## ##STR00039## ##STR00040## ##STR00041## ##STR00042## ##STR00043## ##STR00044## ##STR00045## ##STR00046## ##STR00047## ##STR00048## ##STR00049## ##STR00050## ##STR00051## ##STR00052## ##STR00053## ##STR00054## ##STR00055## ##STR00056## ##STR00057## ##STR00058## ##STR00059## ##STR00060## ##STR00061## ##STR00062## ##STR00063## ##STR00064## ##STR00065## ##STR00066## ##STR00067## ##STR00068## ##STR00069## ##STR00070## ##STR00071## ##STR00072## ##STR00073## ##STR00074## ##STR00075## ##STR00076## ##STR00077## ##STR00078## ##STR00079## ##STR00080## ##STR00081## ##STR00082## ##STR00083## ##STR00084## ##STR00085## ##STR00086## ##STR00087## ##STR00088## ##STR00089## ##STR00090## ##STR00091## ##STR00092## ##STR00093## ##STR00094## ##STR00095## ##STR00096## ##STR00097## ##STR00098## ##STR00099## ##STR00100## ##STR00101##
or a pharmaceutically acceptable salt thereof.

(80) In the fourth aspect, disclosed herein is the process for preparing the compounds of formula (Ia), (Ib), (Ic), (Id), (Ie) and (If) disclosed herein.

(81) The compounds disclosed herein, and/or the pharmaceutically acceptable salts thereof, can be synthesized from commercially available starting materials taken together with the disclosure herein.

(82) Compounds of Formula (Ia, Ib, Ic, Id, Ie and If) may be prepared by the exemplary processes described in the working Examples, as well as relevant published literature procedures that are used by one skilled in the art. Exemplary reagents and procedures for these reactions appear hereinafter and in the working Examples. Protection and de-protection in the processes below may be carried out by procedures generally known in the art (see, for example, Greene, T. W. et al., eds., Protecting Groups in Organic Synthesis, 3.sup.rd Edition, Wiley (1999)). General methods of organic synthesis and functional group transformations are found in: Trost, B. M. et al., eds., Comprehensive Organic Synthesis: Selectivity, Strategy & Efficiency in Modern Organic Chemistry, Pergamon Press, New York, N.Y. (1991); March, J., Advanced Organic Reactions, Mechanisms, and Structure. 4.sup.th Edition, Wiley & Sons, New York, N.Y. (1992); Katritzky, A. R. et al., eds., Comprehensive Organic Functional Groups Transformations, 1.sup.st Edition, Elsevier Science Inc., Tarrytown, N.Y. (1995); Larock, R. C., Comprehensive Organic Transformations, VCH Publishers, Inc., New York, N.Y. (1989), and references therein.

(83) Compounds of the invention (IA) may be prepared according to the following schemes utilizing chemical transformations familiar to anyone of ordinary proficiency in the art of organic/medicinal chemistry. References to many of these transformations can be found in March's Advanced Organic Chemistry Reactions, Mechanisms, and Structure, Fifth Edition by Michael B. Smith and Jerry March, Wiley-Interscience, New York, 2001, or other standard texts on the topic of synthetic organic chemistry.

(84) ##STR00102##

(85) Compounds I can be prepared by a procedure depicted in Scheme A. The starting acid A-1 is converted into the amide A-3 through coupling with substituted benzenediamine. The amide A-3 can be cyclized into the final benzoimidazole by treatment with hot acetic acid.

(86) ##STR00103##

(87) Compounds I can also be prepared by a procedure depicted in Scheme B. The starting ester B-1 is directly converted into the final benzoimidazole by treating it with substituted benzenediamine in the presence of excessive methyl magnesium bromide.

(88) The syntheses of the starting acid and ester are described in the corresponding examples in the experimental part. In the fifth aspect, disclosed herein is a method for treating or preventing hyperproliferative disorders, such as cancer, comprising administrating to a subject, such as a mammal or human in need thereof a pharmaceutically-effective amount of a compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein.

(89) Also disclosed herein is a method for treating or preventing hyperproliferative disorders, such as cancer by inhibiting IDO, comprising administrating to a subject, such as a mammal or human in need thereof a pharmaceutically-effective amount of a compound selected from compounds of Formulas (Ia, b, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein.

(90) Also disclosed herein is a method for treating or preventing cancer including but not limiting to, for example, melanomas, thyroid cancer, Barret's adenocarcinoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, lung cancer, renal carcinoma, head and neck cancer, liver cancer, stomach cancer, esophageal cancer, ovarian cancer, pancreatic cancer, prostate cancer, hematologic cancers, cancer of Billary Tract, Non-small-cell-lung cancer, endometrium cancer, blood cancer, large intestinal colon carcinoma, histiocytic lymphoma, lung adenocarcinoma, comprising administrating to a subject, such as a mammal or human in need thereof a pharmaceutically-effective amount of a compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein.

(91) Also disclosed herein is a method for treating or preventing HIV/AIDS, comprising administrating to a subject, such as a mammal or human in need thereof a pharmaceutically-effective amount of a compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein.

(92) Also disclosed herein is a method for enhancing the effectiveness of an anti-retroviral therapy, comprising administrating to a subject, such as a mammal or human in need thereof an anti-retroviral agent and a pharmaceutically-effective amount of a compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein.

(93) Also disclosed herein is a method of treating cancer responsive to inhibition of IDO and/or TDO comprising administering to a subject, such as a mammal or human, in need of treating for the cancer a pharmaceutically-effective amount of a compound selected from compounds of (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein, wherein the cancer includes but not limiting to, for example, melanomas, thyroid cancer, Barret's adenocarcinoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, lung cancer, renal carcinoma, head and neck cancer, liver cancer, stomach cancer, esophageal cancer, ovarian cancer, pancreatic cancer, prostate cancer, hematologic cancers, cancer of Billary Tract, Non-small-cell-lung cancer, endometrium cancer, blood cancer, large intestinal colon carcinoma, histiocytic lymphoma, lung adenocarcinoma.

(94) Also disclosed herein is a use of a compound selected from compounds of (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein in the manufacture of a medicament for the treatment of cancer responsive to inhibition of IDO and/or TDO, wherein the cancer includes but not limiting to, for example, melanomas, thyroid cancer, Barret's adenocarcinoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, lung cancer, renal carcinoma, head and neck cancer, liver cancer, stomach cancer, esophageal cancer, ovarian cancer, pancreatic cancer, prostate cancer, hematologic cancers, cancer of Billary Tract, Non-small-cell-lung cancer, endometrium cancer, blood cancer, large intestinal colon carcinoma, histiocytic lymphoma, lung adenocarcinoma.

(95) Also disclosed herein is a compound selected from compounds of (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein for use in the treatment of cancer responsive to inhibition of IDO and/or TDO, wherein the cancer includes but not limiting to, for example, melanomas, thyroid cancer, Barret's adenocarcinoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, lung cancer, renal carcinoma, head and neck cancer, liver cancer, stomach cancer, esophageal cancer, ovarian cancer, pancreatic cancer, prostate cancer, hematologic cancers, cancer of Billary Tract, Non-small-cell-lung cancer, endometrium cancer, blood cancer, large intestinal colon carcinoma, histiocytic lymphoma, lung adenocarcinoma.

(96) The compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof may be employed alone or in combination with at least one other therapeutic agent for treatment. In some embodiments, the compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof can be used in combination with at least one additional therapeutic agent. The at least one additional therapeutics agent can be, for example, selected from anti-hyperproliferative, anti-cancer, and chemotherapeutic agents. The at least one compound and/or at least one pharmaceutically acceptable salt disclosed herein may be administered with the at least one other therapeutic agent in a single dosage form or as a separate dosage form. When administered as a separate dosage form, the at least one other therapeutic agent may be administered prior to, at the same time as, or following administration of the at least one compound and/or at least one pharmaceutically acceptable salt disclosed herein.

(97) A “chemotherapeutic agent” is a chemical compound useful in the treatment of cancer, regardless of mechanism of action. Chemotherapeutic agents include compounds used in “targeted therapy” and conventional chemotherapy. Suitable chemotherapeutic agents can be, for example, selected from: agents that induce apoptosis; polynucleotides (e.g., ribozymes); polypeptides (e.g., enzymes); drugs; biological mimetics; alkaloids; alkylating agents; antitumor antibiotics; antimetabolites; hormones; platinum compounds; monoclonal antibodies conjugated with anticancer drugs, toxins, and/or radionuclides; biological response modifiers (e.g., interferons, such as IFN-α and interleukins, such as IL-2); adoptive immunotherapy agents; hematopoietic growth factors; agents that induce tumor cell differentiation (e.g., all-trans-retinoic acid); gene therapy reagents; antisense therapy reagents and nucleotides; tumor vaccines; and inhibitors of angiogenesis.

(98) Examples of chemotherapeutic agents include Erlotinib (TARCEVA®, Genentech/OSI Pharm.); Bortezomib (VELCADE®, Millennium Pharm.); Fulvestrant (FASLODEX®, AstraZeneca); Sunitinib (SUTENT®, Pfizer); Letrozole (FEMARA®, Novartis); Imatinib mesylate (GLEEVEC®, Novartis); PTK787/ZK 222584 (Novartis); Oxaliplatin (Eloxatin®, Sanofi); 5-FU (5-fluorouracil); Leucovorin; Rapamycin (Sirolimus, RAPAMUNE®, Wyeth); Lapatinib (TYKERB®, GSK572016, Glaxo Smith Kline); Lonafarnib (SCH 66336); Sorafenib (NEXAVAR®, Bayer); Irinotecan (CAMPTOSAR®, Pfizer) and Gefitinib (IRESSA®, AstraZeneca); AG1478, AG1571 (SU 5271, Sugen); Trametinib (GSK1120212); Selumetinib (AZD6244); Binimetinib (MEK162); Pimasertib; alkylating agents such as thiotepa and CYTOXAN® cyclosphosphamide; alkyl sulfonates such as busulfan, improsulfan and piposulfan; aziridines such as benzodopa, carboquone, meturedopa, and uredopa; ethylenimines and methylamelamines such as altretamine, triethylenemelamine, triethylenephosphoramide, triethylenethiophosphoramide and trimethylomelamine; acetogenins (such as bullatacin and bullatacinone); a camptothecin (such as the synthetic analog topotecan); bryostatin; callystatin; CC-1065 and its adozelesin, carzelesin and bizelesin synthetic analogs; cryptophycins (such as cryptophycin 1 and cryptophycin 8); dolastatin; duocarmycin and the synthetic analogs thereof, such as KW-2189 and CB-TM1; eleutherobin; pancratistatin; a sarcodictyin; spongistatin; nitrogen mustards such as chlorambucil, chlomaphazine, chlorophosphamide, estramustine, ifosfamide, mechlorethamine, mechlorethamine oxide hydrochloride, melphalan, novembichin, phenesterine, prednimustine, trofosfamide, uracil mustard; nitrosureas such as carmustine, chlorozotocin, fotemustine, lomustine, nimustine, and ranimnustine; antibiotics such as the enediyne antibiotics (e.g., calicheamicin, such as calicheamicin gammaII and calicheamicin omegaIl (Angew Chem. Intl. Ed. Engl. (1994) 33:183-186); dynemicin, such as dynemicin A; bisphosphonates, such as clodronate; an esperamicin; as well as neocarzinostatin chromophore and related chromoprotein enediyne antibiotic chromophores, aclacinomysins, actinomycin, authramycin, azaserine, bleomycins, cactinomycin, carabicin, caminomycin, carzinophilin, chromomycinis, dactinomycin, daunorubicin, detorubicin, 6-diazo-5-oxo-L-norleucine, ADRIAMYCIN® (doxorubicin), morpholino-doxorubicin, cyanomorpholino-doxorubicin, 2-pyrrolino-doxorubicin and deoxydoxorubicin), epirubicin, esorubicin, idarubicin, marcellomycin, mitomycins such as mitomycin C, mycophenolic acid, nogalamycin, olivomycins, peplomycin, porfiromycin, puromycin, quelamycin, rodorubicin, streptonigrin, streptozocin, tubercidin, ubenimex, zinostatin, zorubicin; anti-metabolites such as methotrexate and 5-fluorouracil (5-FU); folic acid analogs such as denopterin, methotrexate, pteropterin, trimetrexate; purine analogs such as fludarabine, 6-mercaptopurine, thiamiprine, thioguanine; pyrimidine analogs such as ancitabine, azacitidine, 6-azauridine, carmofur, cytarabine, dideoxyuridine, doxifluridine, enocitabine, floxuridine; and rogens such as calusterone, dromostanolone propionate, epitiostanol, mepitiostane, testolactone; anti-adrenals such as aminoglutethimide, mitotane, trilostane; folic acid replenisher such as frolinic acid; aceglatone; aldophosphamide glycoside; aminol evulinic acid; eniluracil; amsacrine; bestrabucil; bisantrene; edatraxate; defofamine; demecolcine; diaziquone; elformithine; elliptinium acetate; an epothilone; etoglucid; gallium nitrate; hydroxyurea; lentinan; lonidainine; maytansinoids such as maytansine and ansamitocins; mitoguazone; mitoxantrone; mopidanmol; nitraerine; pentostatin; phenamet; pirarubicin; losoxantrone; podophyllinic acid; 2-ethylhydrazide; procarbazine; PSK® polysaccharide complex (JHS Natural Products, Eugene, Oreg.); razoxane; rhizoxin; sizofuran; spirogermanium; tenuazonic acid; triaziquone; 2,2′,2″-trichlorotriethylamine; trichothecenes (such as T-2 toxin, verracurin A, roridin A and anguidine); urethan; vindesine; dacarbazine; mannomustine; mitobronitol; mitolactol; pipobroman; gacytosine; arabinoside (“Ara-C”); cyclophosphamide; thiotepa; taxoids, e.g., TAXOL® (paclitaxel; Bristol-Myers Squibb Oncology, Princeton, N.J.), ABRAXANE® (Cremophor-free), albumin-engineered nanoparticle formulations of paclitaxel (American Pharmaceutical Partners, Schaumberg, Ill.), and TAXOTERE® (doxetaxel; Rhone-Poulenc Rorer, Antony, France); chloranmbucil; GEMZAR® (gemcitabine); 6-thioguanine; mercaptopurine; methotrexate; platinum analogs such as cisplatin and carboplatin; vinblastine; etoposide (VP-16); ifosfamide; mitoxantrone; vincristine; NAVELBINE® (vinorelbine); novantrone; teniposide; edatrexate; daunomycin; aminopterin; capecitabine (XELODA®); ib and ronate; CPT-11; topoisomerase inhibitor RFS 2000; difluoromethylornithine (DMFO); retinoids such as retinoic acid; and pharmaceutically acceptable salts, acids and derivatives of any of the above.

(99) The “chemotherapeutic agent” can also be selected, for example, from: (i) anti-hormonal agents that act to regulate or inhibit hormone action on tumors such as anti-estrogens and selective estrogen receptor modulators (SERMs), including, for example, tamoxifen (including NOLVADEX®; tamoxifen citrate), raloxifene, droloxifene, 4-hydroxytamoxifen, trioxifene, keoxifene, LY117018, onapristone, and FARESTON® (toremifine citrate); (ii) aromatase inhibitors that inhibit the enzyme aromatase, which regulates estrogen production in the adrenal glands, such as, for example, 4(5)-imidazoles, aminoglutethimide, MEGASE® (megestrol acetate), AROMASIN® (exemestane; Pfizer), formestanie, fadrozole, RIVISOR® (vorozole), FEMARA® (letrozole; Novartis), and ARIMIDEX® (anastrozole; AstraZeneca); (iii) anti- and rogens such as flutamide, nilutamide, bicalutamide, leuprolide, and goserelin; as well as troxacitabine (a 1,3-dioxolane nucleoside cytosine analog); (iv) protein kinase inhibitors such as MEK1/2 inhibitors, for example, trametinib, selumetinib, pimasertib and GDC-0973; (v) lipid kinase inhibitors; (vi) antisense oligonucleotides, such asthose which inhibit expression of genes in signaling pathways implicated in aberrant cell proliferation, such as, for example, PKC-alpha, Ralf and H-Ras; (vii) ribozymes such as VEGF expression inhibitors (e.g., ANGIOZYME®) and HER.sup.2 expression inhibitors; (viii) anti-retroviral protease inhibitors, such as lopinavir, indinavir, nelfinavir, amprenavir, darunavir and atazanavir; (ix) vaccines such as gene therapy vaccines, for example, ALLOVECTIN, LEUVECTIN, and VAXID; PROLEUKIN® rIL-2; a topoisomerase 1 inhibitor such as LURTOTECAN®; ABARELIX® rmRH; (x) anti-angiogenic agents such as bevacizumab (AVASTIN®, Genentech); and (xi) pharmaceutically acceptable salts, acids and derivatives of any of the above.

(100) The “chemotherapeutic agent” can also be selected, for example, from therapeutic antibodies such as alemtuzumab (Campath), bevacizumab (AVASTIN®, Genentech); cetuximab (ERBITUX®, Imclone); panitumumab (VECTIBIX®, Amgen), rituximab (RITUXAN®, Genentech/Biogen Idec), pertuzumab (OMNITARG®, 2C4, Genentech), trastuzumab (HERCEPTIN®, Genentech), tositumomab (Bexxar, Corixia), and the antibody drug conjugate, gemtuzumab ozogamicin (MYLOTARG®, Wyeth).

(101) Humanized monoclonal antibodies with therapeutic potential as chemotherapeutic agents in combination with the compound selected from compounds of Formulas (IA) and/or (IB), stereoisomers thereof, and pharmaceutically acceptable salt thereofmay, for example, be selected from: alemtuzumab, apolizumab, aselizumab, atlizumab, bapineuzumab, bevacizumab, bivatuzumab mertansine, cantuzumab mertansine, cedelizumab, certolizumab pegol, cidfusituzumab, cidtuzumab, daclizumab, eculizumab, efalizumab, elotuzumab, epratuzumab, erlizumab, felvizumab, fontolizumab, gemtuzumab ozogamicin, inotuzumab ozogamicin, ipilimumab, labetuzumab, lintuzumab, mpdl3280A, matuzumab, medi4736, mepolizumab, motavizumab, motovizumab, natalizumab, nimotuzumab, nolovizumab, numavizumab, ocrelizumab, omalizumab, palivizumab, pascolizumab, pecfusituzumab, pectuzumab, Pembroluzima, pertuzumab, pexelizumab, ralivizumab, ranibizumab, reslivizumab, reslizumab, resyvizumab, rovelizumab, ruplizumab, sibrotuzumab, siplizumab, sontuzumab, tacatuzumab tetraxetan, tadocizumab, talizumab, tefibazumab, tocilizumab, toralizumab, trastuzumab, tremelizumab, tucotuzumab celmoleukin, tucusituzumab, umavizumab, urtoxazumab, and visilizumab.

(102) In the sixth aspect, disclosed herein is a pharmaceutical composition comprising a compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein and a pharmaceutically-acceptable excipient, e.g., a carrier, a diluent, or a adjuvant.

(103) Also disclosed herein is a composition comprising a compound selected from compounds of Formulas (a, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

(104) The composition comprising a compound selected from compounds of Formulas (IA) and/or (IB), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof can be administered in various known manners, such as orally, topically, rectally, parenterally, by inhalation spray, or via an implanted reservoir, although the most suitable route in any given case will depend on the particular host, and nature and severity of the conditions for which the active ingredient is being administered. The term “parenteral” as used herein includes subcutaneous, intracutaneous, intravenous, intramuscular, intraarticular, intraarterial, intrasynovial, intrasternal, intrathecal, intralesional and intracranial injection or infusion techniques. The compositions disclosed herein may be conveniently presented in unit dosage form and prepared by any of the methods well known in the art.

(105) The compound selected from Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof can be administered orally in solid dosage forms, such as capsules, tablets, troches, dragées, granules and powders, or in liquid dosage forms, such as elixirs, syrups, emulsions, dispersions, and suspensions. The compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein can also be administered parenterally, in sterile liquid dosage forms, such as dispersions, suspensions or solutions. Other dosages forms that can also be used to administer the compound selected from Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein as an ointment, cream, drops, transdermal patch or powder for topical administration, as an ophthalmic solution or suspension formation, i.e., eye drops, for ocular administration, as an aerosol spray or powder composition for inhalation or intranasal administration, or as a cream, ointment, spray or suppository for rectal or vaginal administration.

(106) Gelatin capsules containing the at least one compound and/or the at least one pharmaceutically acceptable salt thereof disclosed herein and powdered carriers, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like, can also be used. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of time. Compressed tablets can be sugar coated or film coated to mask any unpleasant taste and protect the tablet from the atmosphere, or enteric coated for selective disintegration in the gastrointestinal tract.

(107) Liquid dosage forms for oral administration can further comprise at least one agent selected from coloring and flavoring agents to increase patient acceptance.

(108) In general, water, suitable oil, saline, aqueous dextrose (glucose), and related sugar solutions and glycols such as propylene glycol or polyethylene glycols can be Examples of suitable carriers for parenteral solutions. Solutions for parenteral administration may comprise a water soluble salt of the at least one compound describe herein, at least one suitable stabilizing agent, and if necessary, at least one buffer substance. Antioxidizing agents such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or combined, can be Examples of suitable stabilizing agents. Citric acid and its salts and sodium EDTA can also be used as Examples of suitable stabilizing agents. In addition, parenteral solutions can further comprise at least one preservative, selected, for example, from benzalkonium chloride, methyl- and propylparaben, and chlorobutanol.

(109) A pharmaceutically acceptable carrier is, for example, selected from carriers that are compatible with active ingredients of the composition (and in some embodiments, capable of stabilizing the active ingredients) and not deleterious to the subject to be treated. For example, solubilizing agents, such as cyclodextrins (which can form specific, more soluble complexes with the at least one compound and/or at least one pharmaceutically acceptable salt disclosed herein), can be utilized as pharmaceutical excipients for delivery of the active ingredients. Examples of other carriers include colloidal silicon dioxide, magnesium stearate, cellulose, sodium lauryl sulfate, and pigments such as D&C Yellow #10. Suitable pharmaceutically acceptable carriers are described in Remington's Pharmaceutical Sciences, A. Osol, a standard reference text in the art.

(110) The compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein can further be examined for efficacy in treating cancer by in vivo assays. For example, the at least one compound and/or the at least one pharmaceutically acceptable salts thereof disclosed herein can be administered to an animal (e.g., a mouse model) having cancer and its therapeutic effects can be accessed. Positive results in one or more of such tests are sufficient to increase the scientific storehouse of knowledge and hence sufficient to demonstrate practical utility of the compounds and/or salts tested. Based on the results, an appropriate dosage range and administration route for animals, such as humans, can also be determined.

(111) For administration by inhalation, the compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein may be conveniently delivered in the form of an aerosol spray presentation from pressurized packs or nebulisers. The compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein may also be delivered as powders, which may be formulated and the powder composition may be inhaled with the aid of an insufflation powder inhaler device. One exemplary delivery system for inhalation can be a metered dose inhalation (MDI) aerosol, which may be formulated as a suspension or solution of a compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein in at least one suitable propellant, selected, for example, from fluorocarbons and hydrocarbons.

(112) For ocular administration, an ophthalmic preparation may be formulated with an appropriate weight percentage of a solution or suspension of the compound selected from compounds of Formulas (Ia, b, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein in an appropriate ophthalmic vehicle, such that the compound selected from compounds of Formulas (Ia, b, Ic, Id, Ie and If), stereoisomers thereof, and at least one pharmaceutically acceptable salts thereof disclosed herein is maintained in contact with the ocular surface for a sufficient time period to allow the compound to penetrate the corneal and internal regions of the eye.

(113) Useful pharmaceutical dosage-forms for administration of the compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof disclosed herein include, but are not limited to, hard and soft gelatin capsules, tablets, parenteral injectables, and oral suspensions.

(114) The dosage administered will be dependent on factors, such as the age, health and weight of the recipient, the extent of disease, type of concurrent treatment, if any, frequency of treatment, and the nature of the effect desired. In general, a daily dosage of the active ingredient can vary, for example, from 0.1 to 2000 milligrams per day. For example, 10-500 milligrams once or multiple times per day may be effective to obtain the desired results.

(115) In some embodiments, a large number of unit capsules can be prepared by filling standard two-piece hard gelatin capsules each with, for example, 100 milligrams of the compound selected from compounds of Formulas (Ia, b, Ic, Id, Ie and If), stereoisomers thereof, and pharmaceutically acceptable salt thereof disclosed herein in powder, 150 milligrams of lactose, 50 milligrams of cellulose, and 6 milligrams magnesium stearate.

(116) In some embodiments, a mixture of the compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof a digestible oil such as soybean oil, cottonseed oil or olive oil can be prepared and injected by means of a positive displacement pump into gelatin to form soft gelatin capsules containing 100 milligrams of the active ingredient. The capsules are washed and dried.

(117) In some embodiments, a large number of tablets can be prepared by conventional procedures so that the dosage unit comprises, for example, 100 milligrams of the compound selected from compounds of Formulas (Ia, b, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, 0.2 milligrams of colloidal silicon dioxide, 5 milligrams of magnesium stearate, 275 milligrams of microcrystalline cellulose, 11 milligrams of starch and 98.8 milligrams of lactose. Appropriate coatings may be applied to increase palatability or delay absorption.

(118) In some embodiments, a parenteral composition suitable for administration by injection can be prepared by stirring 1.5% by weight of the at least one compound and/or at least an enantiomer, a diastereomer, or pharmaceutically acceptable salt thereof disclosed herein in 10% by volume propylene glycol. The solution is made to the expected volume with water for injection and sterilized.

(119) In some embodiment, an aqueous suspension can be prepared for oral administration. For example, each 5 milliliters of an aqueous suspension comprising 100 milligrams of finely divided a compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, 100 milligrams of sodium carboxymethyl cellulose, 5 milligrams of sodium benzoate, 1.0 grams of sorbitol solution, U.S.P., and 0.025 milliliters of vanillin can be used.

(120) The same dosage forms can generally be used when the compound selected from compounds of Formulas (Ia, b, Ic, Id, Ie and If), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof are administered stepwise or in conjunction with at least one other therapeutic agent. When drugs are administered in physical combination, the dosage form and administration route should be selected depending on the compatibility of the combined drugs. Thus the term “coadministration” is understood to include the administration of at least two agents concomitantly or sequentially, or alternatively as a fixed dose combination of the at least two active components.

(121) The compound selected from compounds of Formulas (Ia, Ib, Ic, Id, Ie and If), stereoisomers thereof, and pharmaceutically acceptable salt thereof disclosed herein can be administered as the sole active ingredient or in combination with at least one second active ingredient, selected, for example, from other active ingredients known to be useful for treating cancers in a patient.

EXAMPLES

(122) The Examples below are intended to be purely exemplary and should not be considered to be limiting in any way. Efforts have been made to ensure accuracy with respect to numbers used (for example, amounts, temperature, etc.), but some experimental errors and deviations should be accounted for. Unless indicated otherwise, temperature is in degrees Centigrade. Reagents were purchased from commercial suppliers such as Sigma-Aldrich, Alfa Aesar, or TCI, and were used without further purification unless otherwise indicated.

(123) Unless otherwise indicated, the reactions set forth below were performed under a positive pressure of nitrogen or argon or with a drying tube in anhydrous solvents; the reaction flasks were fitted with rubber septa for the introduction of substrates and reagents via syringe; and glassware was oven dried and/or heat dried.

(124) Unless otherwise indicated, column chromatography purification was conducted on a Biotage system (Manufacturer: Dyax Corporation) having a silica gel column or on a silica SepPak cartridge (Waters), or was conducted on a Teledyne Isco Combiflash purification system using prepacked silica gel cartridges.

(125) .sup.1H NMR spectra were recorded on a Varian instrument operating at 400 MHz. .sup.1H-NMR spectra were obtained using CDCl.sub.3, CD.sub.2Cl.sub.2, CD.sub.3OD, D.sub.2O, d.sub.6-DMSO, d.sub.6-acetone or (CD.sub.3).sub.2CO as solvent and tetramethylsilane (0.00 ppm) or residual solvent (CDCl.sub.3: 7.25 ppm; CD.sub.3OD: 3.31 ppm; D.sub.2O: 4.79 ppm; d.sub.6-DMSO: 2.50 ppm; d.sub.6-acetone: 2.05; (CD.sub.3).sub.2CO: 2.05) as the reference standard. When peak multiplicities are reported, the following abbreviations are used: s (singlet), d (doublet), t (triplet), q (quartet), qn (quintuplet), sx (sextuplet), m (multiplet), br (broadened), dd (doublet of doublets), dt (doublet of triplets). Coupling constants, when given, are reported in Hertz (Hz). All compound names except the reagents were generated by ChemDraw version 12.0.

(126) In the following Examples, the abbreviations below are used: AcOH Acetic acid Aq Aqueous Brine Saturated aqueous sodium chloride solution Bn Benzyl BnBr Benzyl Bromide Boc Tert-butyloxycarbonyl Cbz benzyloxycarbonyl CH.sub.2Cl.sub.2 Dichloromethane DMF N,N-Dimethylformamide Dppf 1,1″-bis(diphenylphosphino)ferrocene DBU 1,8-diazabicyclo[5.4.0]undec-7-ene DIEA or DIPEA N,N-diisopropylethylamine DIBAL-H Diisobutylaluminium hydride DMAP 4-N,N-dimethylaminopyridine DMF N,N-dimethylformamide DMSO Dimethyl sulfoxide EA or EtOAc Ethyl acetate EtOH Ethanol Et.sub.2O or ether Diethyl ether g Grams h or hr Hour HATU O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate HBTU O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate HCl Hydrochloric acid Hex Hexane HPLC High-performance liquid chromatography IPA 2-propanol i-PrOH Isopropyl alcohol mg Milligrams mL Milliliters Mmol Millimole MeCN Acetonitrile MeOH Methanol Min Minutes ms or MS Mass spectrum Na.sub.2SO.sub.4 Sodium sulfate PE petroleum ether PPA Polyphosphoric acid Rt Retention time Rt or rt Room temperature TBAF Tetra-butyl ammonium fluoride TBSCl tert-Butyldimethylsilyl chloride TFA Trifluoroacetic acid THE Tetrahydrofuran TLC thin layer chromatography Ts para-toluenesulfonyl TBS tert-butyldimethylsilyl μL Microliters

Synthesis of substituted benzo[d]imidazols

Example A1a: 4-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(127) ##STR00104##

Step 1: 6-fluoro-4-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)quinoline

(128) To a solution of 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane (13.3 g, 50 mmol, 1.00 eq) dissolved in 1,4-dioxane (250 ml) and water (1 ml), 4-bromo-6-fluoroquinoline (11.3 g, 50 mmol, 1.00 eq), Pd(dppf)Cl.sub.2 (5.50 g, 7.5 mmol, 0.15 eq) and Cs.sub.2CO.sub.3 (24.38 g, 75 mmol, 1.50 eq) were added. The mixture was stirred at 90° C. overnight under N.sub.2. TLC showed the starting material was disappeared completely, then the solvent was evaporated under reduced pressure. The crude was purified by column chromatography on silica gel 100 g (PE/EA=4/1 to 2/1) to give the title compound (12.43 g, 87% yield) as a pale-yellow oil. .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.80 (d, J=4.4 Hz, 1H), 8.05-8.15 (m, 1H), 7.60-7.66 (m, 1H), 7.43-7.50 (m, 1H), 7.24 (d, J=4.4 Hz, 1H), 5.73-5.77 (m, 1H), 4.05-4.08 (m, 4H), 2.59-2.65 (m, 2H), 2.52-2.55 (m, 2H) and 1.99 (t, J=6.4 Hz, 2H).

Step 2: 6-fluoro-4-(1,4-dioxaspiro[4.5]decan-8-yl)quinoline

(129) To a mixture of 6-fluoro-4-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)quinoline (12.43 g, 44 mmol, 1.00 eq) in THF (100 ml), Pd/C (2.48 g, 20% w.t.) was added. The mixture was stirred at room temperature under one hydrogen balloon protection for 48 hours. The solution was filtered and concentrated to give the crude product (12.50 g, 100% yield), which was used for next step without further purification. .sup.1H NMR (CDCl.sub.3).sup.6H8.77 (d, J=4.4 Hz, 1H), 8.09-8.19 (m, 1H), 7.62-7.68 (m, 1H), 7.42-7.50 (m, 1H), 7.33 (d, J=4.8 Hz, 1H), 3.96-4.01 (m, 4H), 3.16-3.24 (m, 1H), 1.89-1.99 (m, 5H) and 1.75-1.86 (m, 3H).

Step 3: 4-(6-fluoroquinolin-4-yl)cyclohexan-1-one

(130) 6-fluoro-4-(1,4-dioxaspiro[4.5]decan-8-yl)quinoline (12.5 g, 43.5 mmol, 1.00 eq) was dissolved in CF.sub.3COOH (150 ml) and the mixture was stirred at 70° C. under nitrogen protection for 48 hours. The solvent was concentrated to dryness. The crude was added to saturated Na.sub.2CO.sub.3 aqueous solution 300 mL and extracted with EA (200 ml×3). The organic layer was combined, dried over Na.sub.2SO.sub.4, filtered and concentrated to give the crude product (10.35 g), which was used for next step without further purification. .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.87 (d, J=4.4 Hz, 1H), 8.16-8.27 (m, 1H), 7.70-7.80 (m, 1H), 7.51-7.60 (m, 1H), 7.34 (d, J=4.4 Hz, 1H), 3.64-3.76 (m, 1H), 2.57-2.74 (m, 4H), 2.34-2.42 (m, 2H) and 2.02-2.09 (m, 2H).

Step 4: methyl 2-(4-(6-fluoroquinolin-4-yl)cyclohexylidene)acetate

(131) To a mixture of 4-(6-fluoroquinolin-4-yl)cyclohexan-1-one (10.33 g, 43 mmol, 1.00 eq) dissolved in toluene (250 ml), compound 5 (28.4 g, 85 mmol, 2.00 eq) and TEA (8.58 g, 85 mmol, 2.00 eq) were added. And the mixture was stirred at 100° C. for overnight. Then the mixture was cooled to room temperature and concentrated to dryness. The crude product was purified by column chromatography on silica gel 100 g (PE/EA=5/1) to give a clear oil (7.00 g, 55% yield). .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.79-8.86 (m, 1H), 8.05-8.50 (m, 1H), 7.72-7.80 (m, 1H), 7.51-7.61 (m, 1H), 7.30-7.42 (m, 1H), 5.76 (s, 1H), 3.73 (s, 3H), 3.45-3.54 (m, 1H), 2.48-2.57 (m, 2H), 2.14-2.30 (m, 3H), 1.68-1.85 (m, 2H) and 1.24-1.29 (m, 1H).

Step 5: methyl 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetate

(132) To a mixture of methyl 2-(4-(6-fluoroquinolin-4-yl)cyclohexylidene)acetate (7.00 g, 23 mmol, 1.00 eq) in MeOH (100 ml), Pd/C (2.10 g, w.t. 30%) was added. The mixture was stirred at room temperature under hydrogen (one balloon) for 45 hours. The solution was filtered and concentrated to dryness. The crude product (5.40 g, 76% yield) was used for next step without further purification. .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.76-8.85 (m, 1H), 8.04-8.17 (m, 1H), 7.60-7.69 (m, 1H), 7.42-7.49 (m, 1H), 7.26-7.32 (m, 1H), 3.70 (s, 3H), 3.07-3.19 (m, 1H), 2.24-2.45 (m, 2H), 1.96-2.05 (m, 3H), 1.74-1.85 (m, 2H), 1.52-1.72 (m, 2H) and 1.21-1.43 (m, 2H).

Step 6: 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetic acid

(133) To a mixture of methyl 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetate (5.40 g, 18 mmol, 1.00 eq) in MeOH (20 ml), NaOH (2 N, 10 mL, 1.10 eq) was added. The mixture was stirred at room temperature for 2 hours. The solvent was concentrated to 10 ml and extracted with EA (20 ml×3) to remove the impurities. The water layer was concentrated to 5 ml. The water layer was neutralized with 1 N HCl to make the PH to 7. Then some white solid was precipitated, filtered and washed with water (1 ml) to get a white solid (2.94 g, 57% yield). .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.04 (s, 1H), 8.78-8.84 (m, 1H), 8.05-8.11 (m, 1H), 7.93-8.00 (m, 1H), 7.63-7.70 (m, 1H), 7.44-7.55 (m, 1H), 3.24-3.31 (m, 1H), 2.40-2.47 (m, 1H), 2.17-2.20 (m, 1H), 1.90-1.95 (m, 4H), 1.50-1.75 (m, 4H) and 1.31-1.38 (m, 1H).

Step 7: 4-((1r,4r)-4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline and 4-((1s,4s)-4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(134) ##STR00105##

(135) To a mixture of 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetic acid (0.57 g, 2 mmol, 1.00 eq) in DCM (20 ml), 4-chlorobenzene-1,2-diamine (0.28 g, 2 mmol, 1.00 eq), HATU (0.76 g, 2 mmol, 1.00 eq) and TEA (0.40 g, 4 mmol, 2.00 eq) were added. The mixture was stirred at room temperature overnight. The solvent was extracted with saturated NH.sub.4Cl aqueous solution (50 ml×3). The organic layer was dried over Na.sub.2SO.sub.4, filtered and concentrated to dryness. The crude was dissolved in CH.sub.3COOH (20 ml) and stirred at 100° C. for 2 hours. Then the mixture was concentrated to dryness. The crude product was added to saturated Na.sub.2CO.sub.3 aqueous solution 50 mL and extracted with DCM (40 ml×3). The organic layer was combined, dried over Na.sub.2SO.sub.4, filtered and concentrated to dryness. The crude product was purified by pre-HPLC to give the desired two compounds: Ala (123 mg, 16% yield): .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 8.81 (d, J=4.4 Hz, 1H), 8.04-8.12 (m, 1H), 7.95-8.02 (m, 1H), 7.59-7.72 (m, 2H), 7.55 (m, J=8.8 Hz, 1H), 7.41-7.47 (m, 1H), 7.17-7.25 (m, 1H), 3.28-3.37 (m, 1H), 2.85 (d, J=7.2 Hz, 2H), 1.95-2.06 (m, 1H), 1.80-1.95 (m, 4H) and 1.33-1.64 (m, 4H). A1b (287 mg, 36% yield): .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.78 (d, J=4.4 Hz, 1H), 8.06-8.14 (m, 1H), 7.56-7.64 (m, 2H), 7.52 (d, J=8.4 Hz, 1H), 7.41-7.49 (m, 1H), 7.18-7.26 (m, 2H), 3.06-3.17 (m, 1H), 2.95 (d, J=6.8 Hz, 2H), 1.90-2.14 (m, 5H), 1.49-1.64 (m, 2H) and 1.30-1.46 (m, 2H).

(136) Compounds A2 to A37 were prepared in a procedure similar to Example Ala.

Example A2a: 6-fluoro-4-((1r,4r)-4-((5-methyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(137) ##STR00106##

(138) .sup.1H NMR (DMSO-d6) δ 12.29 (s, 1H), 8.80 (d, J=4.8 Hz, 1H), 8.08 (dd, J=9.2, 6.0 Hz, 1H), 7.99 (dd, J=10.8, 2.4 Hz, 1H), 7.70-7.62 (m, 2H), 7.44 (d, J=4.4 Hz, 2H), 7.29 (d, J=8.0 Hz, 1H), 7.02 (t, J=7.4 Hz, 2H), 6.92 (d, J=7.2 Hz, 1H), 2.80 (d, J=3.2 Hz, 3H), 2.05-1.95 (m, 2H), 1.91-1.84 (m, 6H), 1.62-1.63 (m, 4H), 1.48-1.39 (m, 4H), MS (ESI) m/e [M+1]+ 374.

Example A2b: 6-fluoro-4-((1s,4s)-4-((5-methyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(139) ##STR00107##

(140) .sup.1H NMR (DMSO-d6) δ 12.16 (s, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 5.6 Hz, 1H), 7.99 (dd, J=10.8, 2.8 Hz, 1H), 7.67 (td, J=8.4, 2.4 Hz, 1H), 7.59 (d, J=4.8 Hz, 1H), 7.29 (d, J=6.8 Hz, 1H), 7.00 (t, J=7.6 Hz, 1H), 6.91 (d, J=7.2 Hz, 1H), 3.02 (d, J=8.0 Hz, 2H), 2.51-2.49 (m, 4H), 1.91-1.82 (m, 5H), 1.68 (d, J=8.5 Hz, 5H), MS (ESI) m/e [M+1]+ 374.

Example A3a: 6-fluoro-4-((1s,4s)-4-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(141) ##STR00108##

(142) .sup.1H NMR (DMSO-d6) δ 12.68 (s, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.99 (dd, J=10.8, 2.4 Hz, 1H), 7.90 (s, 1H), 7.81-7.62 (m, 3H), 7.59 (d, J=4.4 Hz, 1H), 7.45 (t, J=8.4 Hz, 1H), 3.45-3.35 (m, 1H), 3.09 (d, J=8.0 Hz, 2H), 1.89-1.86 (m, 4H), 1.71-1.65 (m, 4H), MS (ESI) m/e [M+1]+ 428;

Example A3b: 6-fluoro-4-((1r,4r)-4-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(143) ##STR00109##

(144) .sup.1H NMR (DMSO-d6) δ 8.81 (d, J=4.4 Hz, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.99 (dd, J=10.8, 2.4 Hz, 1H), 7.88 (s, 1H), 7.75-7.61 (m, 2H), 7.50-7.45 (m, 2H), 3.39-3.29 (m, 1H), 2.87 (d, J=7.2 Hz, 2H), 2.03 (s, 1H), 1.88 (t, J=13.8 Hz, 4H), 1.62-1.54 (m, 2H), 1.49-1.40 (m, 2H), MS (ESI) m/e [M+1]+ 428.

Example A4a: 4-((1r,4r)-4-((5-cyclopropyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(145) ##STR00110##

(146) .sup.1H NMR (400 MHz, DMSO-d) δH 12.12 (s, 1H), 8.80 (d, J=4.4 Hz, 1H), 8.08 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.8 Hz, 1H), 7.68-7.63 (m, 1H), 7.44 (d, J=4.4 Hz, 1H), 7.34 (d, J=8.2 Hz, 1H), 7.15 (s, 1H), 6.87 (d, J=7.6 Hz, 1H), 3.33-3.31 (m, 1H), 2.76 (d, J=7.2 Hz, 2H), 2.02-1.82 (m, 5H), 1.62-1.33 (m, 5H), 0.91-0.85 (m, 2H), 0.68-0.61 (m, 2H). [M+H].sup.+=400.2.

Example A4b: 4-((1s,4s)-4-((5-cyclopropyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(147) ##STR00111##

(148) 1H NMR (400 MHz, DMSO-d) δ.sub.H 12.06 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.4 Hz, 1H), 7.73-7.64 (m, 1H), 7.58 (d, J=4.4 Hz, 1H), 7.34 (d, J=8.0 Hz, 1H), 7.15 (s, 1H), 6.86 (d, J=8.4 Hz, 1H), 3.38 (br, 1H), 2.99 (d, J=8.0 Hz, 2H), 2.02-1.95 (m, 1H), 1.86-1.84 (m, 4H), 1.71-1.59 (m, 4H), 1.42-1.33 (m, 1H), 0.93-0.85 (m, 2H), 0.66-0.63 (m, 2H). [M+H].sup.+=400.2.

Example A5a: 6-fluoro-4-((1r,4r)-4-((5-isopropyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(149) ##STR00112##

(150) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.16 (s, 1H), 8.80 (d, J=4.8 Hz, 1H), 8.10-7.97 (m, 2H), 7.68-7.64 (m, 1H), 7.45-7.27 (m, 3H), 7.02 (d, J=8.4 Hz, 1H), 3.33 (br, 1H), 3.01-2.95 (m, 1H), 2.77 (d, J=6.8 Hz, 2H), 1.99-1.84 (m, 5H), 1.61-1.43 (m, 4H), 1.24 (d, J=6.8 Hz, 6H). [M+H]+=402.2.

Example A5b: 6-fluoro-4-((1s,4s)-4-((5-isopropyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(151) ##STR00113##

(152) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.06 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.12-8.06 (m, 1H), 7.98 (d, J=10.8 Hz, 1H), 7.71-7.65 (m, 1H), 7.58 (d, J=4.4 Hz, 1H), 7.37 (br, 2H), 7.01 (d, J=8.4 Hz, 1H), 3.39 (br, 1H), 3.03-2.89 (m, 3H), 2.44 (br, 1H), 1.87-1.85 (m, 4H), 1.69-1.64 (m, 4H), 1.24 (d, J=6.4 Hz, 6H). [M+H]+=402.2.

Example A6a: 4-((1r,4r)-4-((5,6-difluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(153) ##STR00114##

(154) .sup.1H NMR (400 MHz, DMSO-d6): δ.sub.H 12.44 (s, 1H), 8.78 (d, J=4.8 Hz, 1H), 8.06 (dd, J=9.2, 6.0 Hz, 1H), 7.96 (dd, J=11.2, 2.8 Hz, 1H), 7.70-7.32 (m, 4H), 3.31-3.29 (m, 1H), 2.76 (d, J=6.8 Hz, 2H), 2.00-1.78 (m, 5H), 1.59-1.34 (m, 4H). [M+H]+=396.1

Example A6b: 4-((1s,4s)-4-((5,6-difluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(155) ##STR00115##

(156) .sup.1H NMR (400 MHz, DMSO-d6): δ.sub.H 12.44 (s, 1H), 8.84 (d, J=4.4 Hz, 1H), 8.08 (dd, J=9.2, 5.6 Hz, 1H), 7.97 (dd, J=11.2, 2.8 Hz, 1H), 7.70-7.45 (m, 4H), 3.36-3.33 (m, 1H), 3.00 (d, J=8.0 Hz, 2H), 2.42 (br, 1H), 1.86-1.82 (m, 4H), 1.70-1.59 (m, 4H). [M+H]+=396.1

Example A7a: 6-(((1r,4r)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazole

(157) ##STR00116##

(158) .sup.1H NMR (400 MHz, DMSO-d) δH 12.21 (s, 1H), 8.78 (s, 1H), 8.06 (br, 1H), 7.96 (d, J=10.8 Hz, 1H), 7.64 (br, 1H), 7.42 (s, 1H), 7.00 (s, 2H), 5.94 (s, 2H), 3.27-3.19 (br, 1H), 2.71-2.69 (m, 2H), 1.96-1.75 (m, 5H), 1.56-1.36 (m, 4H). [M+H]+=404.1.

Example A7b: 6-(((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazole

(159) ##STR00117##

(160) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.03 (s, 1H), 8.86 (s, 1H), 8.12-8.06 (m, 1H), 7.98 (d, J=10.8 Hz, 1H), 7.70-7.62 (m, 1H), 7.58-7.56 (m, 1H), 7.04-6.97 (m, 2H), 5.95 (d, J=3.6 Hz, 2H), 3.38 (br, 1H), 2.95-2.92 (m, 2H), 2.40 (br, 1H), 1.88-1.61 (m, 8H). [M+H]+=404.1.

Example A8a: 4-((1r,4r)-4-((5-cyclopropoxy-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(161) ##STR00118##

(162) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.04 (s, 1H), 8.80 (s, 1H), 8.17-7.88 (m, 2H), 7.71-7.66 (m, 1H), 7.45-7.11 (m, 3H), 6.78 (br, 1H), 3.83 (br, 1H), 3.31 (br, 1H), 2.75 (s, 2H), 1.91-1.84 (m, 5H), 1.58-1.40 (m, 4H), 0.77-0.66 (m, 4H). [M+H]+=416.2.

Example A8b: 4-((1s,4s)-4-((5-cyclopropoxy-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(163) ##STR00119##

(164) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.05 (s, 1H), 8.87 (s, 1H), 8.15-7.99 (m, 2H), 7.68-7.58 (m, 2H), 7.48-7.08 (m, 2H), 6.77 (s, 1H), 3.83 (s, 1H), 3.39 (s, 1H), 2.98 (s, 2H), 2.43 (s, 1H), 1.87 (s, 4H), 1.69-1.65 (m, 4H), 0.77-0.66 (m, 4H). [M+H]+=416.2.

Example A9a: 4-((1r,4r)-4-((5,6-dimethyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(165) ##STR00120##

(166) .sup.1H NMR (DMSO-d6) δ 11.91 (s, 1H), 8.80 (d, J=4.4 Hz, 1H), 8.08 (dd, J=9.2, 5.6 Hz, 1H), 7.98 (dd, J=11.2, 2.8 Hz, 1H), 7.66 (td, J=8.4, 2.8 Hz, 1H), 7.44 (d, J=4.4 Hz, 1H), 7.29 (s, 1H), 7.17 (s, 1H), 3.30 (s, 1H), 2.73 (d, J=7.2 Hz, 2H), 2.28 (d, J=6.0 Hz, 6H), 1.92-1.79 (m, 5H), 1.61-1.52 (m, 2H), 1.45-1.36 (m, 2H), MS (ESI) m/e [M+1]+ 388;

Example A9b: 4-((1s,4s)-4-((5,6-dimethyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(167) ##STR00121##

(168) .sup.1H NMR (DMSO-d6) δ 12.31 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.4 Hz, 1H), 7.67 (td, J=8.8, 2.8 Hz, 1H), 7.57 (d, J=4.8 Hz, 1H), 7.26 (s, 2H), 3.45-3.46 (m, 2H), 3.00 (d, J=8.0 Hz, 3H), 2.29 (s, 7H), 1.86-1.84 (m, 4H), 1.73-1.58 (m, 5H), MS (ESI) m/e [M+1]+ 388;

Example A10a: 4-((1r,4r)-4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(169) ##STR00122##

(170) .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 12.44 (s, 1H), 8.81 (d, J=4.4 Hz, 1H), 8.22 (d, J=8.4 Hz, 1H), 8.01 (d, J=8.4 Hz, 1H), 7.74 (t, J=7.6 Hz, 1H), 7.62 (t, J=7.6 Hz, 1H), 7.46-7.56 (m, 1H), 7.40 (t, J=4.0 Hz, 1H), 7.11-7.18 (m, 1H), 3.36-3.45 (m, 1H), 2.80 (d, J=7.2 Hz, 2H), 1.95-2.08 (m, 1H), 1.83-1.96 (m, 4H), 1.53-1.65 (m, 2H) and 1.33-1.45 (m, 2H).

Example A10b: 4-((1s,4s)-4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(171) ##STR00123##

(172) .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 12.46 (s, 1H), 8.87 (d, J=4.8 Hz, 1H), 8.23 (d, J=8.8 Hz, 1H), 8.03 (d, J=8.4 Hz, 1H), 7.75 (t, J=8.0 Hz, 1H), 7.63 (t, J=8.0 Hz, 1H), 7.42-7.59 (m, 3H), 7.09-7.18 (m, 1H), 3.43-3.52 (m, 1H), 3.03 (d, J=8.0 Hz, 2H), 2.43-2.51 (m, 1H), 1.90-1.95 (m, 4H) and 1.60-1.75 (m, 4H).

Example A11a: 4-((1r,4r)-4-((5-bromo-4-methyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(173) ##STR00124##

(174) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.37 (s, 1H), 8.80 (d, J=4.0 Hz, 1H), 8.06-8.10 (m, 1H), 7.96-8.00 (m, 1H), 7.63-7.73 (m, 2H), 7.44 (d, J=4.0 Hz, 1H), 7.27-7.30 (m, 1H), 2.80 (d, J=7.6 Hz, 2H), 2.55 (s, 3H), 1.83-1.99 (m, 4H), 1.52-1.66 (m, 3H), and 1.34-1.48 (m, 3H). [M+H].sup.+=452.

Example A1b: 4-((1s,4s)-4-((5-bromo-4-methyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(175) ##STR00125##

(176) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.36 (s, 1H), 8.87 (d, J=4.0 Hz, 1H), 8.08-8.12 (m, 1H), 7.97-8.01 (m, 1H), 7.64-7.70 (m, 1H), 7.59 (d, J=4.0 Hz, 1H), 7.25-7.26 (m, 2H), 303 (d, J=8.4 Hz, 2H), 2.54 (s, 3H), 1.85-1.88 (m, 4H), and 1.64-1.71 (m, 6H). [M+H].sup.+=452.

Example A12: 4-(4-((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(177) ##STR00126##

(178) .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 8.85 (d, J=4.4 Hz, 1H), 8.05-8.13 (m, 1H), 7.93-8.01 (m, 1H), 7.63-7.75 (m, 3H), 7.55 (s, 1H), 3.03 (d, J=7.6 Hz, 2H), 2.31-2.47 (m, 2H), 1.77-1.93 (m, 4H), 1.58-1.73 (m, 4H).

Example A13: methyl 2-((4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole-5-carboxylate

(179) ##STR00127##

(180) .sup.1H NMR (400 MHz, CDCl.sub.3) δ.sub.H 8.80 (d, J=4.4 Hz, 1H), 8.33 (s, 1H), 8.13 (dd, J=9.2, 5.6 Hz, 1H), 8.00 (d, J=8.8 Hz, 1H), 7.60-7.67 (m, 2H), 7.49 (t, J=8.0 Hz, 1H), 7.43 (d, J=4.4 Hz, 1H), 3.92 (s, 3H), 3.24 (d, J=8.0 Hz, 3H), 2.64 (s, 1H), 1.66-1.97 (m, 8H).

Example A14: 2-((4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole-5-carboxylic acid

(181) ##STR00128##

(182) .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 12.11 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.88-8.04 (m, 2H), 7.62-7.77 (m, 2H), 7.59 (d, J=4.4 Hz, 1H), 7.17-7.35 (m, 1H), 3.00 (d, J=7.8 Hz, 2H), 2.53-2.54 (m, 2H), 1.81-1.97 (m, 4H), 1.59-1.76 (m, 4H).

Example A15: 6-fluoro-4-(4-((5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(183) ##STR00129##

(184) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.10 (s, 1H), 8.85 (s, 1H), 8.05-8.10 (m, 1H), 7.94-7.96 (m, 1H), 7.61-7.68 (m, 2H), 7.51-7.53 (m, 1H), 7.28-7.37 (m, 1H), 6.99-7.03 (m, 1H), 4.18-4.23 (m, 2H), 23.36-3.48 (m, 3H), 3.00 (d, J=6.4 Hz, 2H), 2.36-2.38 (m, 2H), 1.83-1.85 (m, 4H), 1.58-1.68 (m, 5H), and 1.35-1.51 (m, 6H). [M+H].sup.+=457.

Example A16: 4-(4-((6-bromo-5-(piperidin-1-yl)-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(185) ##STR00130##

(186) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.25 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.08-8.12 (m, 1H), 7.97-8.00 (m, 1H), 7.65-7.70 (m, 2H), 7.58 (d, J=4.4 Hz, 1H), 7.20-7.22 (m, 1H), 3.39-3.49 (m, 2H), 2.99 (d, J=7.6 Hz, 2H), 2.86-2.88 (m, 4H), 1.83-1.90 (m, 4H), 1.62-1.69 (m, 8H), and 1.53-1.54 (m, 2H). [M+H].sup.+=521.

Example A17: 4-(4-((6-bromo-5-methoxy-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(187) ##STR00131##

(188) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.24 (s, 1H), 8.86 (d, J=4.0 Hz, 1H), 8.08-8.12 (m, 1H), 7.96-8.01 (m, 1H), 7.62-7.73 (m, 2H), 7.58 (d, J=4.0 Hz, 1H), 7.10 (s, 1H), 3.86 (s, 3H), 3.38-3.40 (m, 1H), 3.00 (d, J=8.0 Hz, 2H), 2.40-2.43 (m, 1H), 1.81-1.89 (m, 4H), and 1.63-1.70 (m, 4H). [M+H].sup.+=468.

Example A18: 2-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(189) ##STR00132##

(190) .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 12.39 (s, 1H), 8.25 (d, J=8.4 Hz, 1H), 7.91 (t, J=7.2 Hz, 2H), 7.70 (t, J=7.2 Hz, 1H), 7.35-7.60 (m, 4H), 7.13 (d, J=8.4 Hz, 1H), 2.85 (t, J=11.6 Hz, 1H), 2.87 (d, J=7.2 Hz, 1H), 1.79-2.03 (m, 5H), 1.59-1.73 (m, 2H) and 1.19-1.32 (m, 2H).

Example A19: 3-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(191) ##STR00133##

(192) .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 12.46 (s, 1H), 8.84 (s, 1H), 8.13 (s, 1H), 7.88-8.00 (m, 2H), 7.69 (t, J=7.6 Hz, 1H), 7.52-7.62 (m, 2H), 7.45-7.52 (d, J=8.4 Hz, 1H), 7.15 (d, J=8.4 Hz, 1H), 2.70-2.82 (m, 3H), 1.90-1.99 (m, 5H), 1.52-1.64 (m, 2H) and 1.22-1.34 (m, 2H).

Example A20: 2-(4-((1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(193) ##STR00134##

(194) .sup.1H NMR (400 MHz, CDCl.sub.3) δ.sub.H 8.09 (d, J=8.4 Hz, 1H), 8.02 (d, J=8.4 Hz, 1H), 7.77 (d, J=8.0 Hz, 1H), 7.66 (t, J=7.2 Hz, 1H), 7.57-7.63 (m, 2H), 7.48 (t, J=7.2 Hz, 1H), 7.24-7.29 (m, 4H), 2.83-2.97 (m, 3H), 1.88-2.12 (m, 5H), 1.59-1.74 (m, 2H), 1.20-1.35 (m, 2H).

Example A21: 2-(4-((5-methoxy-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(195) ##STR00135##

(196) .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 12.03 (s, 1H), 8.26 (d, J=8.0 Hz, 1H), 7.82-8.04 (m, 2H), 7.64-7.76 (m, 1H), 7.41-7.58 (m, 2H), 7.29-7.39 (m, 1H), 6.99 (s, 1H), 6.66-6.81 (m, 1H), 3.77 (s, 4H), 2.79-2.91 (m, 1H), 2.65-2.77 (m, 2H), 1.76-2.06 (m, 6H), 1.52-1.76 (m, 2H), 1.12-1.34 (m, 2H).

Example A22: 5-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(197) ##STR00136##

Example A23a: 6-((1r,4r)-4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(198) ##STR00137##

(199) .sup.1H NMR (DMSO-d6) δ 12.41 (d, J=16.4 Hz, 1H), 8.83 (s, 1H), 8.28 (d, J=8.4 Hz, 1H), 7.93 (d, J=8.4 Hz, 1H), 7.76 (s, 1H), 7.67 (d, J=8.4 Hz, 1H), 7.59-7.53 (m, 1H), 7.49-7.43 (m, 2H), 7.14 (t, J=8.8 Hz, 1H), 2.77 (d, J=6.8 Hz, 2H), 2.73-2.65 (m, 1H), 1.93-1.83 (m, 5H), 1.56 (dd, J=24.4, 12.4 Hz, 2H), 1.30-1.24 (m, 3H), MS (ESI) m/e [M+1]+ 376;

Example A23b: 6-((1s,4s)-4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(200) ##STR00138##

(201) .sup.1H NMR (DMSO-d6) δ 12.44 (s, 1H), 8.84 (dd, J=4, 1.6 Hz, 1H), 8.32 (d, J=16 Hz, 1H), 7.97 (d, J=8.4 Hz, 1H), 7.85 (s, 1H), 7.75 (dd, J=8.8, 1.6 Hz, 1H), 7.58-7.42 (m, 3H), 7.14 (dd, J=8.4, 2.0 Hz, 1H), 2.99 (d, J=8.0 Hz, 2H), 2.83-2.77 (m, 1H), 2.44-2.32 (m, 1H), 2.00-1.85 (m, 2H), 1.73-1.59 (m, 6H), MS (ESI) m/e [M+1]+ 376;

Example A24: 8-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-5-fluoroquinoline

(202) ##STR00139##

Example A25: 5-(4-((5-cyclopropyl-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-8-fluoroquinoline

(203) ##STR00140##

(204) .sup.1H NMR (DMSO-d6) δ 12.03 (d, J=17.2 Hz, 1H), 8.98-8.90 (m, 1H), 8.66 (d, J=7.6 Hz, 1H), 7.69-7.62 (m, 1H), 7.60-7.56 (m, 1H), 7.55-7.42 (m, 1H), 7.39-7.36 (m, 1H), 7.21-7.09 (m, 1H), 6.85-6.83 (m, 1H), 3.33-3.31 (m, 3H), 2.99-2.74 (m, 3H), 2.05-1.76 (m, 7H), 1.73-1.49 (m, 4H), 1.40-1.37 (m, 1H), 0.96-0.86 (m, 2H), 0.68-0.60 (m, 2H), MS (ESI) m/e [M+1]+ 400;

Example A26a: 5-((1r,4r)-4-((5,6-difluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-8-fluoroquinoline

(205) ##STR00141##

(206) .sup.1H NMR (DMSO-d6) δ 12.45 (s, 1H), 8.95 (dd, J=4.0, 1.6 Hz, 1H), 8.65 (d, J=8.8 Hz, 1H), 7.65 (dd, J=8.8, 4.4 Hz, 1H), 7.61-7.42 (m, 4H), 3.31-3.26 (m, 1H), 2.78 (d, J=6.8 Hz, 2H), 2.00-1.93 (m, 1H), 1.89-1.83 (m, 4H), 1.62-1.53 (m, 2H), 1.43-1.34 (m, 2H), MS (ESI) m/e [M+1]+ 396;

Example A26b: 5-((1s,4s)-4-((5,6-difluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-8-fluoroquinoline

(207) ##STR00142##

(208) .sup.1H NMR (DMSO-d6) δ 12.46 (s, 1H), 8.96 (d, J=4.0 Hz, 1H), 8.66 (d, J=8.4 Hz, 1H), 7.66 (dd, J=8.8, 4.0 Hz, 1H), 7.58 (d, J=8.0 Hz, 3H), 7.52-7.48 (m, 2H), 3.33-3.30 (m, 1H), 3.01 (d, J=8.0 Hz, 2H), 2.47-2.39 (m, 1H), 1.86-1.83 (m, 4H), 1.69-1.66 (m, 4H), MS (ESI) m/e [M+1]+ 396;

Example A27: 8-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-5-fluoroquinoline

(209) ##STR00143##

Example A28:5-chloro-2-((4-(pyridin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole

(210) ##STR00144##

Example A29:5-chloro-2-((4-(2-(trifluoromethyl)pyridin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole

(211) ##STR00145##

Example A30a: 5-chloro-2-(((1r,4r)-4-(4-fluorophenyl)cyclohexyl)methyl)-1H-benzo[d]imidazole

(212) ##STR00146##

(213) .sup.1H NMR (DMSO-d6) δ 12.38 (s, 1H), 7.56-7.48 (m, 2H), 7.25-7.23 (m, 2H), 7.16-7.00 (m, 3H), 2.73 (d, J=6.8 Hz, 2H), 1.78 (d, J=10.8 Hz, 5H), 1.41 (q, J=11.6 Hz, 2H), 1.23-1.14 (m, 2H), MS (ESI) m/e [M+1]+ 343;

Example A30b: 5-chloro-2-(((1s,4s)-4-(4-fluorophenyl)cyclohexyl)methyl)-1H-benzo[d]imidazole

(214) ##STR00147##

(215) .sup.1H NMR (DMSO-d6) 12.39 (s, 1H), 7.58-7.43 (m, 2H), 7.35-7.30 (m, 2H), 7.14-7.10 (m, 3H), 2.95 (d, J=7.6 Hz, 2H), 2.58 (t, J=12.2 Hz, 1H), 2.34 (s, 1H), 1.80-1.72 (m, 3H), 1.65-1.57 (m, 6H), MS (ESI) m/e [M+1]+ 343;

Example A31: 5-cyclopropyl-2-((4-phenylcyclohexyl)methyl)-1H-benzo[d]imidazole

(216) ##STR00148##

(217) .sup.1H NMR (CDCl3) δ.sub.H 7.48 (d, J=8.4 Hz, 1H), 7.33 (s, 1H), 7.19-7.21 (m, 4H), 7.03-7.11 (m, 2H), 3.17-3.20 (m, 2H), 2.45-2.51 (m, 2H), 1.87-1.92 (m, 1H), 1.70-1.77 (m, 2H), 1.56-1.63 (m, 4H), 1.45-1.49 (m, 2H), 0.91-0.97 (m, 2H), and 0.59-0.64 (m, 2H). MS (ESI) m/e [M+H].sup.+=331.

Example A32: 2-((4-phenylcyclohexyl)methyl)-1H-benzo[d]imidazole

(218) ##STR00149##

(219) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 7.55-7.57 (m, 2H), 7.30-7.34 (m, 4H), 7.18-7.24 (m, 3H), 3.04 (d, J=7.6 Hz, 2H), 2.58-2.67 (m, 3H), 2.32-2.39 (m, 1H), 1.75-1.82 (m, 2H), and 1.54-1.68 (m, 6H). MS (ESI) m/e [M+H].sup.+=291.

Example A33a: 2-(((1r,4r)-4-phenylcyclohexyl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

(220) ##STR00150##

(221) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 7.85 (s, 1H), 7.67 (d, J=8.0 Hz, 1H), 7.44-7.48 (m, 1H), 7.11-7.29 (m, 5H), 2.81 (d, J=7.2 Hz, 2H), 2.44-2.49 (m, 1H), 1.91-1.96 (m, 1H), 1.78-1.82 (m, 4H), 1.40-1.50 (m, 2H), and 1.16-1.27 (m, 2H). MS (ESI) m/e [M+H]=359.

Example A33b: 2-(((1s,4s)-4-phenylcyclohexyl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

(222) ##STR00151##

(223) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.69 (s, 1H), 7.84 (s, 1H), 7.66 (d, J=8.4 Hz, 1H), 7.43-7.47 (m, 1H), 7.29-7.34 (m, 4H), 7.16-7.21 (m, 1H), 3.02 (d, J=8.0 Hz, 2H), 2.54-2.58 (m, 1H), 2.36-2.40 (m, 1H), 1.76-1.85 (m, 2H), and 1.54-1.68 (m, 6H). MS (ESI) m/e [M+H].sup.+=359.

Example A34a: 5-chloro-2-(((1r,4r)-4-phenylcyclohexyl)methyl)-1H-benzo[d]imidazole

(224) ##STR00152##

(225) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 7.46-7.53 (m, 2H), 7.45-7.48 (m, 1H), 7.12-7.29 (m, 6H), 2.73 (d, J=8.0 Hz, 2H), 2.47-2.52 (m, 1H), 1.77-1.91 (m, 5H), 1.42-1.46 (m, 2H), and 1.18-1.24 (m, 2H). MS (ESI) m/e [M+H].sup.+=325

Example A34b: 5-chloro-2-(((1s,4s)-4-phenylcyclohexyl)methyl)-1H-benzo[d]imidazole

(226) ##STR00153##

(227) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 7.60 (s, 1H), 7.53 (d, J=8.0 Hz, 1H), 7.26-7.32 (m, 4H), 7.17-7.22 (m, 2H), 3.01 (d, J=8.0 Hz, 2H), 2.55-2.60 (m, 1H), 2.31-2.38 (m, 1H), 1.66-1.77 (m, 2H), and 1.53-1.63 (m, 6H). MS (ESI) m/e [M+H].sup.+=325.

Example A35: 4-chloro-2-(((1s,4s)-4-phenylcyclohexyl)methyl)-1H-benzo[d]imidazole

(228) ##STR00154##

(229) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.67 (s, 1H), 7.45 (d, J=7.6 Hz, 1H), 7.28-7.34 (m, 4H), 7.11-7.22 (m, 3H), 3.00 (d, J=8.0 Hz, 2H), 2.54-2.61 (m, 1H), 2.37-2.39 (m, 1H), 1.76-1.87 (m, 2H), and 1.53-1.68 (m, 6H). MS (ESI) m/e [M+H].sup.+=325.

Example A36: 5-chloro-2-(3-phenylbicyclo[4.1.0]heptan-7-yl)-1H-benzo[d]imidazole

(230) ##STR00155##

(231) .sup.1H NMR (400 MHz, CDCl3) δ 7.53-7.52 (m, 1H), 7.41 (d, J=8.8 Hz, 1H), 7.24-7.19 (m, 2H), 7.17-7.15 (m, 2H), 7.07-6.99 (m, 2H), 2.40-2.00 (m, 8H), 1.98-1.78 (m, 2H), 1.71-1.46 (m, 3H), and 1.40-1.20 (m, 3H). MS (ESI) m/e [M+1].sup.+=323.

Example A37a: 6-bromo-5-fluoro-2-(((1r,4r)-4-phenylcyclohexyl)methyl)-1H-benzo[d]imidazole

(232) ##STR00156##

(233) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.57 (s, 1H), 7.78-7.79 (d, J=6.4 Hz, 1H), 7.50-7.52 (d, J=9.2 Hz, 1H), 7.13-7.26 (m, 5H), 2.73-2.75 (d, J=7.6 Hz, 2H), 2.43-2.50 (m, 1H), 1.86-1.96 (m, 1H), 1.77-1.80 (d, J=11.6 Hz, 4H), 1.38-1.49 (m, 2H), and 1.14-1.25 (m, 2H). MS (ESI) m/e[M+1].sup.+=387.

Example A37b: 6-bromo-5-fluoro-2-(((1s,4s)-4-phenylcyclohexyl)methyl)-1H-benzo[d]imidazole

(234) ##STR00157##

(235) .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 12.58 (s, 1H), 7.78-7.80 (d, J=6.4 Hz, 1H), 7.50-7.52 (d, J=9.6 Hz, 1H), 7.28-7.33 (m, 4H), 7.16-7.20 (m, 1H), 2.94-2.96 (d, J=8.0 Hz, 2H), 2.51-2.61 (m, 1H), 2.30-2.37 (m, 1H), 1.73-1.83 (m, 2H), and 1.54-1.66 (m, 6H). MS (ESI) m/e[M+1].sup.+=387.

Example A38: 4-(1-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)-6-fluoroquinoline

(236) ##STR00158##

Step 1: tert-butyl 4-(6-fluoroquinolin-4-yl)-3,6-dihydropyridine-1(2H)-carboxylate

(237) A mixture of tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate (3.1 g, 0.01 mol), 4-bromo-6-fluoroquinoline (2.24 g, 0.01 mol), Cs.sub.2CO.sub.3(6.51 g, 0.02 mol), and Pd(dppf)Cl.sub.2(731 mg, 0.001 mol) in 1,4-dioxane was stirred overnight at 100° C. under N.sub.2. After determined the reaction to be complete by LCMS and TLC, the reaction was cooled to r.t. The solvent was removed under vacuo. The residue was purified by silica gel column (PE:EA=2:1) to afford desired product 3.42 g as yellow oil. [M+1].sup.+ 329.

Step 2: tert-butyl 4-(6-fluoroquinolin-4-yl)piperidine-1-carboxylate

(238) To a solution of tert-butyl 4-(6-fluoroquinolin-4-yl)-3,6-dihydropyridine-1(2H)-carboxylate (3.42 g, 1.04 mmol) in THF (25 mL) was added Pd/C (684 mg, 20%). The mixture was stirred overnight under 4 atm of H.sub.2 at r.t. After determined the reaction to be complete by LCMS, the solid was filtered and the filtrate was concentrated to give the crude product (3.45 g) as a yellow oil, which was used for the next step without further purification. [M+1].sup.+ 331.

Step 3: 6-fluoro-4-(piperidin-4-yl)quinoline

(239) To a solution of tert-butyl 4-(6-fluoroquinolin-4-yl)piperidine-1-carboxylate (1 g, 3.00 mmol) in DCM (10 ml) was added TFA (5 ml). The mixture was stirred for 2 h at r.t. After determined the reaction to be complete by LCMS, the solvent was removed under vacuo. The residue was added to 50 ml DCM, and washed with saturated aqueous of NaHCO.sub.3 (30 mL×2), the organic layer was combined and washed with brine (40 mL×1), dried over Na.sub.2SO.sub.4, filtered and concentrated to afford desired product 560 mg as yellow oil. [M+1].sup.+ 231.

Step 4: ethyl 3-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)propanoate

(240) To a solution of 6-fluoro-4-(piperidin-4-yl)quinoline (560 mg, 2.43 mmol) in DMF (10 ml), were added K.sub.2CO.sub.3(840 mg, 6.09 mmol), ethyl 3-chloropropanoate (497 mg, 3.65 mmol). The mixture was stirred over weekend at r.t. After determined the reaction to be complete by LCMS, the mixture was added to H.sub.2O (80 ml), extracted with EA (80 mL×2). The organic layer was combined and washed with brine (100 mL×1), dried over Na.sub.2SO.sub.4, filtered and concentrated to give the crude product (850 mg) as a yellow solid. [M+1].sup.+ 331.

Step 5: 3-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)propanoic acid

(241) To a solution of ethyl 3-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)propanoate (1.49 g, 4.5 mmol) in MeOH (10 ml) was added NaOH (10%, 10 ml). The mixture was stirred for 2 h at r.t. After determined the reaction to be complete by LCMS, MeOH was removed under vacuo. The pH value of residue aqueous layer was adjusted to 5˜6 with HCl (12M), and the aqueous layer was extracted with DCM (50 mL×2), EA (50 mL×2). The organic layer was combined and washed with brine (100 mL×1), dried over Na.sub.2SO.sub.4, filtered and concentrated to afford desired crude product 850 mg as off-white solid. [M+1]303.

Step 6: N-(2-amino-4-chlorophenyl)-3-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)propenamide

(242) A mixture of 3-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)propanoic acid (850 mg, 2.81 mmol) and HATU (1.28 g, 3.38 mmol) in DCM (10 mL) was stirred for 10 mins under N.sub.2 at r.t. Then 4-chlorobenzene-1,2-diamine (399 mg, 2.81 mmol) and TEA (568 mg, 5.62 mmol) were added. The mixture was stirred for 2 h at r.t. After determined the reaction to be complete by LCMS, the reaction mixture was extracted with DCM (30 mL×2). The organic layer was combined and washed with brine (50 mL×1), dried over Na.sub.2SO.sub.4, filtered and concentrated to give a crude product 1.14 g as red solid, which was used for the next step without further purification. [M+1].sup.+ 427.

Step 7: 4-(1-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)-6-fluoroquinoline

(243) ##STR00159##

(244) A solution of N-(2-amino-4-chlorophenyl)-3-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)propenamide (880 mg crude, 2.05 mmol) in CH.sub.3COOH (15 mL) was stirred for 3 h at 80° C. After determined the reaction to be complete by LCMS, the reaction mixture was concentrated in vacuo to remove the solvent, and the residue was purified by prep-HPLC, to afford desired product 105.14 mg as white solid. .sup.1H NMR (DMSO-d.sub.6) δ 12.36 (s, 1H), 8.81 (d, J=4.0 Hz, 1H), 8.05 (m, 2H), 7.68 (t, J=8.0 Hz, 1H), 7.50 (m, 3H), 7.15 (d, J=8.0 Hz, 1H), 3.15-2.97 (m, 4H), 3.15-2.83 (m, 7H), 2.34 (t, J=10.0 Hz, 2H), 1.92-1.70 (m, 5H), [M+1].sup.+ 409. Compound A39 was prepared in a procedure similar to Example A38.

Example A39: 4-(1-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-4-yl)-6-fluoroquinoline

(245) ##STR00160##

(246) .sup.1H NMR (DMSO-d.sub.6) δ 12.57 (s, 1H), 8.88 (d, J=4.0 Hz, 1H), 8.15 (dd, J=8.0, 4.0 Hz, 1H), 8.07 (dd, J=12.0, 2.0 Hz, 1H), 7.77-7.48 (m, 4H), 7.28-7.16 (m, 1H), 3.90 (s, 2H), 3.43 (s, 1H), 3.08 (d, J=8.0 Hz, 2H), 2.51 (s, 2H), 2.00-1.80 (m, 4H), [M+1].sup.+ 395.

Example A40: 4-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-1-yl)quinoline

(247) ##STR00161##

Step 1: Synthesis of 8-(quinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane

(248) To a solution of 1,4-dioxa-8-azaspiro[4.5]decane (10 g, 70 mmol) in toluene (150 ml) were added 4-bromoquinoline (15.2 g, 73.5 mmol), Pd.sub.2(dba).sub.3(6.4 g, 7 mmol), x-phos (6.7 g, 14 mmol) and Cs.sub.2CO.sub.3(57 g, 175 mmol). The mixture was stirred for 3 days at 110° C. under N.sub.2. The solid was filtered and the filtrate was purified by column chromatography on silica, eluting with EA:PE=1:1 to 1: 0 to give 8-(quinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane (10.8 g). MS (EST) m/e [M+H].sup.+=271.

Step 2: 1-(quinolin-4-yl)piperidin-4-one

(249) A solution of 8-(quinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane (10.8 g, 40 mmol) in CF.sub.3COOH (20 ml) was stirred overnight at 50° C. The solvent was removed under vacuo, the residue was adjusted to the pH>7 with Na.sub.2CO.sub.3(aq.) then extracted with EA (50 ml×3). The organic layer was dried over Na.sub.2SO.sub.4, filtered and concentrated to give 1-(quinolin-4-yl)piperidin-4-one (9.6 g) which was used in next step without further purification. MS (ESI) m/e [M+H].sup.+=227.

Step 3: methyl 2-(1-(quinolin-4-yl)piperidin-4-ylidene)acetate

(250) To a solution of 1-(quinolin-4-yl)piperidin-4-one (9.6 g, 42.5 mmol) in toluene (60 ml) were added methoxycarbonylmethylene-triphenylphosphorane (15.6 g, 46.8 mmol) and Et.sub.3N (8.6 g, 85 mmol). The mixture was stirred overnight at 100° C. under N.sub.2. The mixture was purified by column chromatography on silica, eluting with EA:PE=1:1 to give methyl 2-(1-(quinolin-4-yl)piperidin-4-ylidene)acetate (5.7 g). MS (ESI) m/e [M+H].sup.+=283.

Step 4: methyl 2-(1-(quinolin-4-yl)piperidin-4-yl)acetate

(251) To a solution of methyl 2-(1-(quinolin-4-yl)piperidin-4-ylidene)acetate (5.7 g, 20 mmol) in MeOH (60 ml) was added Pd/C (2.3 g). The mixture was stirred for 7 days at r.t. under H.sub.2(4 atm). The solid was filtered and the filtrate was concentrated under vacuo to give methyl 2-(1-(quinolin-4-yl)piperidin-4-yl)acetate (5 g) which was used in next step without further purification. MS (ESI) m/e [M+H].sup.+=285.

Step 5: 2-(1-(quinolin-4-yl)piperidin-4-yl)acetic acid

(252) To a solution of methyl 2-(1-(quinolin-4-yl)piperidin-4-yl)acetate (5 g, 17.5 mmol) in MeOH (50 ml) and H.sub.2O (10 ml) was added NaOH (1.4 g, 35 mmol). The mixture was stirred for 2 h at r.t. The solvent was removed under vacuo. The residue was acidified by HCl (1N, aq.) to the pH=7. The solid was filtered and dried to give 2-(1-(quinolin-4-yl)piperidin-4-yl)acetic acid (1.4 g). MS (ESI) m/e [M+H].sup.+=271.

Step 6: N-(2-amino-5-chlorophenyl)-2-(1-(quinolin-4-yl)piperidin-4-yl)acetamide

(253) To a solution of 2-(1-(quinolin-4-yl)piperidin-4-yl)acetic acid (1.4 g, 5.2 mmol) in DMF (30 ml) were added 4-chlorobenzene-1,2-diamine (744 mg, 5.2 mmol), HATU (2.0 g, 5.2 mmol) and Et.sub.3N (1.1 g, 10.4 mmol). The mixture was stirred overnight at r.t. To the mixture was added H.sub.2O (20 ml). The solid was filtered and dried to give N-(2-amino-5-chlorophenyl)-2-(1-(quinolin-4-yl)piperidin-4-yl)acetamide (600 mg). MS (ESI) m/e [M+H].sup.+=395.

Step 7: 4-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-1-yl)quinoline

(254) ##STR00162##

(255) A solution of N-(2-amino-5-chlorophenyl)-2-(1-(quinolin-4-yl)piperidin-4-yl)acetamide (600 mg, 1.52 mmol) in CH.sub.3COOH (20 ml) was stirred overnight at 100° C. under N.sub.2. The solvent was removed under vacuo, the residue was adjusted to the pH>7 with Na.sub.2CO.sub.3(aq.) then extracted with EA (50 ml×3). The organic layer was dried over Na.sub.2SO.sub.4, filtered and concentrated to give crude product which was further purified by column chromatography on silica, eluting with EA:PE=1:1 to give 4-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-1-yl)quinoline (300 mg). .sup.1H NMR (DMSO-d.sub.6).sub.6) 12.45 (s, 1H), 8.66 (d, J=4.8 Hz, 1H), 7.91-7.99 (m, 2H), 7.65-7.70 (m, 1H), 7.44-7.59 (m, 3H), 7.12-7.17 (m, 1H), 6.96 (d, J=4.8 Hz, 1H), 3.52-3.56 (m, 2H), 2.73-2.89 (m, 4H), 2.09-2.12 (m, 1H), 1.83-1.87 (m, 2H), and 1.58-1.67 (m, 2H). [M+H].sup.+=377.

Example A41: 4-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-1-yl)-6-fluoroquinoline

(256) ##STR00163##

Step 1: methyl 2-(1-(6-fluoroquinolin-4-yl)piperidin-4-ylacetate

(257) To a solution of 4-bromo-6-fluoroquinoline (4.5 g, 20 mmol) in DMF (60 mL) were added methyl 2-(piperidin-4-yl)acetate (3.77 g, 24 mmol), Cs.sub.2CO.sub.3 (9.8 g, 30 mmoL), Pd(dba).sub.2 (1.8 g, 2 mmol) and S-Phos (0.4 g, 1 mmol). Warmed to 100° C. and stirred for 5 hours under N.sub.2. The reaction was then quenched with H.sub.2O (150 mL) and extracted with EA (100 mL). Separated the organic phase and washed with brine (150 mL). Concentrated and used for next step directly without further purification.

Step 2: 2-(1-(6-fluoroquinolin-4-yl)piperidin-4-yl)acetic acid

(258) To a solution of methyl 2-(1-(6-fluoroquinolin-4-yl)piperidin-4-yl)acetate (8 g, 26.5 mmol) in THF/MeOH/H.sub.2O (2:2:1, 100 mL) was added LiOH.H.sub.2O (1.3 g, 0.03 mol). Stirred at 20-30° C. for 5 hours. Evaporated the organic solution, added H.sub.2O (50 mL) and EA (50 mL), separated the aqueous phase and extracted with EA (50 mL*2). The aqueous phase was adjusted pH to 6˜7 with HCl (4N). Extracted with EA (50 mL*2). Combined the organic phase and concentrated to 5˜10 mL. Filtered and washed the filter cake with EA (5 mL). Dried the filter cake under reduced pressure to give product 3 g as yellow solid. .sup.1H NMR (400 MHz, DMSO-d6): δ.sub.H 12.13 (s, 1H), 8.67 (d, J=4.8 Hz, 1H), 8.02 (dd, J=9.2, 5.6 Hz, 1H), 7.64-7.56 (m, 2H), 7.02 (d, J=4.8 Hz, 1H), 3.47 (d, J=12.0 Hz, 2H), 2.81 (t, J=11.2 Hz, 2H), 2.29 (d, J=6.8 Hz, 2H), 1.95-1.85 (m, 3H), 1.58-1.49 (m, 2H).

Step 3: 4-(4-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-1-yl)-6-fluoroquinoline

(259) ##STR00164##

(260) To a mixture of 2-(1-(6-fluoroquinolin-4-yl)piperidin-4-yl)acetic acid (0.14 g, 0.5 mmol) and 4-chlorobenzene-1,2-diamine (0.08 g, 0.6 mmol) was added PPA (10 mL). The mixture was stirred at 140° C. for 4 hours. The reaction was then quenched with H.sub.2O (50 mL) and EA (50 mL). The pH value of the solution was adjusted to 8˜9 with NaOH solution. Concentrated the organic phase and purified by pre-HPLC. .sup.1H NMR (400 MHz, DMSO-d6): δ.sub.H 12.44 (br, 1H), 8.66 (d, J=4.8 Hz, 1H), 8.03-7.99 (m, 1H), 7.76-7.30 (m, 4H), 7.15 (d, J=8.0 Hz, 1H), 7.02 (d, J=4.8 Hz, 1H), 3.49 (d, J=12.0 Hz, 2H), 2.91-2.75 (m, 4H), 2.11 (s, 1H), 1.86-1.83 (m, 2H), 1.67-1.58 (m, 2H). [M+H].sup.+=395.1

Example B1a: 4-((1S,4s)-4-((R)-1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(261) ##STR00165##

Step 1: ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate

(262) ##STR00166##

(263) To a solution of compound ethyl 2-(4-oxocyclohexyl)acetate (18.4 g, 100 mmol, 1.00 eq) dissolved in DCM (250 ml) were added pyridine (9.48 g, 120 mmol, 1.20 eq) and Tf.sub.2O (42.15 g, 150 mmol, 1.50 eq). The mixture was stirred at room temperature for overnight. The solution was washed with water 400 ml, saturated ammonium chloride 400 ml and brine 400 ml. The organic layer was combined, dried over Na.sub.2SO.sub.4, filtered and concentrated to dryness. The crude (30.32 g, 95% yield) was used for next step without further purification. .sup.1H NMR (CDCl.sub.3) δ.sub.H 5.72 (s, 1H), 4.15 (q, J=7.2 Hz, 2H), 2.39-2.51 (m, 1H), 2.28-2.38 (m, 4H), 2.08-2.21 (m, 1H), 1.87-1.98 (m, 2H), 1.45-1.57 (m, 1H) and 1.27 (t, J=7.2 Hz, 3H).

Step 2: ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)acetate

(264) ##STR00167##

(265) To a mixture of ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate (30.3 g, crude, 96 mmol, 1.00 eq) dissolved in 1,4-dioxane (400 ml), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (26.8 g, 106 mmol, 1.10 eq), CH.sub.3COOK (38.02 g, 192 mmol, 2.00 eq) and Pd(dppf)Cl.sub.2 (14.04 g, 19.2 mmol, 0.20 eq) were added. The mixture was stirred at 95° C. under nitrogen protection for 18 hours. The solution was filtered and concentrated to dryness. The crude (12.50 g, 100% yield) was filtered through the silica gel pad and washed with PE/EA=6:1. The filtrate was concentrated to dryness to give a black oil (33.2 g, 112.3% yield) which was used in next step without further purification. .sup.1H NMR (CDCl.sub.3) δ.sub.H6.51 (s, 1H), 4.13 (q, J=7.2 Hz, 3H), 1.99-2.40 (m, 9H), 1.68-1.94 (m, 3H) and 1.18-1.26 (m, 12H).

Step 3: ethyl 2-(4-(6-fluoroquinolin-4-yl)cyclohex-3-en-1-yl)acetate

(266) ##STR00168##

(267) Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)acetate (33.02 g, 110 mmol, 1.10 eq) was dissolved in 1,4-dioxane (450 ml) and was added with 4-bromo-6-fluoroquinoline (22.5 g 100 mmol, 1.00 eq), Cs.sub.2CO.sub.3 (65 g, 200 mmol, 2.00 eq) and Pd(dppf)Cl.sub.2 (14.62 g, 20 mmol, 0.20 eq). The mixture was stirred at 95° C. under nitrogen protection for 18 hours. The solution was filtered and concentrated to dryness. The crude was purified by column chromatography on silica gel 200 g (PE/EA=10/1 to 4/1) to give a clear oil (12.02 g, 34.8% yield). .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.80 (d, J=4.4 Hz, 1H), 8.15 (dd, J=9.2, 5.6 Hz, 1H), 7.62 (dd, J=10.0, 2.8 Hz, 1H), 7.49 (m, 1H), 7.21 (d, J=4.4 Hz, 1H), 5.81-5.87 (m, 1H), 4.19 (q, J=7.2 Hz, 2H), 2.23-2.57 (m, 6H), 1.95-2.04 (m, 2H), 1.53-1.65 (m, 1H) and 1.30 (t, J=7.2 Hz, 3H).

Step 4: ethyl 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetate

(268) ##STR00169##

(269) To a mixture of ethyl 2-(4-(6-fluoroquinolin-4-yl)cyclohex-3-en-1-yl)acetate (12.02 g, 38 mmol, 1.00 eq) dissolved in MeOH (50 ml) was added Pd/C (2.4 g, w.t. 20%). And the mixture was stirred at room temperature under one hydrogen balloon for overnight. Then the mixture was filtered and concentrated to dryness. The crude was purified by column chromatography on silica gel 150 g (PE/EA=10/1 to 2/1) to give a pale yellow oil (8.51 g, 70.3% yield). .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.77-8.86 (m, 1H), 8.15 (dd, J=9.2, 5.6 Hz, 1H), 7.66 (dd, J=10.4, 2.4 Hz, 1H), 7.44-7.52 (m, 1H), 7.28-7.38 (m, 1H), 4.16 (q, J=7.2 Hz, 2H), 3.07-3.32 (m, 1H), 2.45-2.53 (m, 2H), 1.92-2.10 (m, 3H), 1.53-1.89 (m, 6H) and 1.28 (t, J=7.2, 4.0 Hz, 3H).

Step 5: 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetic acid

(270) ##STR00170##

(271) To a mixture of ethyl 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetate (8.51 g, 27 mmol, 1.00 eq) dissolved in MeOH (20 ml) and water (20 ml) was added NaOH (1.61 g, 40.5 mmol, 1.50 eq). The mixture was stirred at room temperature for 2 hours. The solvent was concentrated to 20 ml and extracted with EA (20 mL×3) to remove the impurities. The water layer was concentrated to 5 ml. The water layer was neutralized with 1N HCl to make the PH to 7. Then the mixture was added to water 200 ml and extracted with DCM/MeOH (20/1, 400 ml×3). The organics was dried over Na.sub.2SO.sub.4, filtered and concentrated to give crude product, which was recrystilazed in water to give product (7.74 g). .sup.1H NMR (DMSO-d.sub.6) δ.sub.H 8.84 (t, J=4.4 Hz, 1H), 8.11-8.25 (m, 1H), 7.66 (dd, J=10.4, 2.4 Hz, 1H), 7.44-7.54 (m, 1H), 7.28-7.40 (m, 1H), 3.09-3.32 (m, 1H), 2.31-2.64 (m, 3H), 1.96-2.10 (m, 2H), 1.72-1.91 (m, 4H), 1.56-1.69 (m, 1H) and 1.29-1.45 (m, 1H).

Step 6: (R)-3-(2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)acetyl)-4-phenyloxazolidin-2-one

(272) ##STR00171##

(273) To a flask # a were added 2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)acetic acid (7.74 g, 27 mmol, 1.00 eq), THE (250 ml) and TEA (8.5 ml, 2.00 eq). The mixture was stirred at −78° C. for 0.5 hours. Pivaloyl chloride (3.5 ml, 1.95 eq) was added to the flask dropwised under nitrogen protection. Then the mixture was warmed to 0° C. and stirred for 1 hour.

(274) To a flask # b were added (R)-4-phenyloxazolidin-2-one (3.55 g, 29 mmol, 1.10 eq) and THE (60 ml). The solution was cooled to −78° C. before the careful addition of n-BuLi (1.6 N, 34 ml, 2.00 eq). And the mixture was stirred at −78° C. for 0.5 hour.

(275) Flask # a was then cooled to −78° C. and the contents of Flask # b were added to Flask # a via cannula over the course of 15 minutes. After addition was completed, the cold bath was removed, and the reaction was stirred for 3 hours at room temperature. The reaction was quenched with saturated ammonium chloride solution 500 ml and extracted with EA (500 ml×3). The organic layer was combined, dried over Na.sub.2SO.sub.4, filtered and concentrated to dryness. The crude was purified by column chromatography on silica gel 100 g (PE/EA=4/1 to 1/1) to give product as a white solid, which was slurried in 2-methoxy-2-methylpropane to give product as cis-product, and the mother liquid was cis and trans mixture. Cis-product .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.77-8.86 (m, 1H), 8.24 (s, 1H), 7.66 (dd, J=10.2, 2.4 Hz, 1H), 7.51 (t, J=8.4 Hz, 1H), 7.28-7.45 (m, 6H), 5.47 (dd, J=8.8, 3.6 Hz, 1H), 4.68-4.79 (m, 2H), 4.26-4.35 (m, 1H), 2.93-3.27 (m, 2H), 2.41-2.56 (m, 1H), 1.89-2.01 (m, 2H), 1.67-1.84 (m, 4H), 1.47-1.63 (m, 1H), 1.28-1.39 (m, 1H).

Step 7: (R)-3-((R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoyl)-4-phenyloxazolidin-2-one

(276) ##STR00172##

(277) To a solution of NaHMDS (1.0 N, 14 ml, 2.00 eq) was added (R)-3-(2-((s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)acetyl)-4-phenyloxazolidin-2-one (3.55 g, 8 mmol, 1.00 eq) in THE 80 ml at −78° C. The mixture was warmed to −20° C. and stirred for 1 hour. Then the mixture was cooled to −78° C. and added iodomethane (7.50 g, 3.3 ml, 5.00 eq). The mixture was stirred at this temperature for 2 hours and quenched with saturated ammonium chloride solution 100 ml and extracted with EA (100 ml×3). The organic layer was combined, dried over Na.sub.2SO.sub.4, filtered and concentrated to dryness. The crude was purified by column chromatography on silica gel 100 g (PE/EA=4/1 to 1/1) to give product (2.11 g, 41% yield) as a pale yellow solid. .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.77-8.85 (m, 1H), 8.09-8.18 (m, 1H), 7.62-7.70 (m, 1H), 7.44-7.50 (m, 1H), 7.29-7.44 (m, 6H), 5.38-5.52 (m, 2H), 4.91-5.00 (m, 1H), 4.66-4.79 (m, 2H), 4.16-4.38 (m, 2H), 2.10-2.20 (m, 1H), 1.86-2.03 (m, 2H), 1.65-1.83 (m, 4H), 1.45-1.64 (m, 1H), 1.12 (t, J=7.2 Hz, 2H).

Step 8: (R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoic acid

(278) ##STR00173##

(279) To a solution of (R)-3-((R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoyl)-4-phenyloxazolidin-2-one (2.71 g, 6 mmol, 1.00 eq) dissolved in THF (40 ml) and water (10 ml) was added H.sub.2O (5 ml) dropwised at 0° C. The mixture was stirred at 0° C. for 1 hour. Then the mixture was added with LiOH (2 N, 6 ml, 2.00 eq) and stirred at room temperature for 4 hours. Progress was followed by LC/MS and the mixture was carefully quenched at 0° C. by the addition of saturated Na.sub.2SO.sub.3 once starting material had been consumed. The PH was adjusted to 5˜6 with 1N HCl and then the mixture was extracted with DCM/MeOH (40/1, 50 ml x 4). The organics was dried over Na.sub.2SO.sub.4, filtered and concentrated to dryness get a pale yellow solid (1.02 g, not pure, 55% yield). .sup.1H NMR (CDCl.sub.3) δ.sub.H 8.82 (d, J=4.6 Hz, 1H), 8.11-8.20 (m, 1H), 7.63-7.72 (m, 1H), 7.45-7.53 (m, 1H), 7.27-7.33 (m, 1H), 3.12-3.33 (m, 1H), 2.34-2.49 (m, 1H), 1.57-2.14 (m, 9H), 1.20-1.29 (m, 3H).

Step 9: 4-((1S,4s)-4-((R)-1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(280) ##STR00174##

(281) To a solution of (R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoic acid (0.2 g, 0.66 mmol) in DMF (10 mL), HATU (0.3 g, 0.8 mmol), DIEA (0.5 mL) were added at room temperature. Then 4,5-difluorobenzene-1,2-diamine (0.14 g, 0.8 mmol) was added. The mixture was stirred at 20-30° C. for 48 hours. The reaction was then quenched with H.sub.2O (50 mL), Extracted with EA (50 mL), Separated the organic phase and washed with brine (100 mL). Concentrated the organic phase to give the crude product (R)—N-(2-amino-4,5-difluorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide, which was used to the next step without further purification.

(282) A solution of (R)—N-(2-amino-4,5-difluorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide in HOAc (20 mL) was stirred at 100° C. for 18 hours. The solvent was evaporated. The crude residue was dissolved with EA (50 mL) and washed with saturated NaHCO.sub.3 solution (50 mL). Separated the organic phase and purified by pre-HPLC to give the title compound. .sup.1H NMR (400 MHz, DMSO-d) d.sub.H 12.45 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.4 Hz, 1H), 7.71-7.62 (m, 1H), 7.58-7.40 (m, 3H), 3.45-3.38 (m, 2H), 2.16-1.99 (m, 2H), 1.94-1.46 (m, 7H), 1.33 (d, J=6.8 Hz, 3H). [M+H].sup.+=409.9.

Example B1b: 4-((1R,4s)-4-((S)-1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(283) ##STR00175##

Example B1c: 4-((1R,4r)-4-((R)-1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(284) ##STR00176##

Example B1d: 4-((1S,4r)-4-((S)-1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(285) ##STR00177##

Example B2: 4-((1S,4s)-4-((R)-1-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(286) ##STR00178##

Step 1: (R)—N-(2-amino-5-chloro-4-fluorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide

(287) To a solution of (R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoic acid (0.36 g, 01.2 mmol) in DMF (10 mL) were added HATU (0.54 g, 1.4 mmol), DIEA (0.5 mL) at room temperature. 4-chloro-5-fluorobenzene-1,2-diamine (0.23 g, 1.4 mmol) was added. The mixture was stirred at 50° C. for 18 hours. The reaction was then quenched with H.sub.2O (50 mL), extracted with EA (50 mL*2), and the the organic phase was separated and washed with brine (100 mL). The organic phase was concentrated for next step directly without further purification.

Step 2: 4-((1S,4s)-4-((R)-1-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(288) ##STR00179##

(289) A solution of (R)—N-(2-amino-5-chloro-4-fluorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide in HOAc (20 mL) was stirred at 80° C. for 18 hours. The solvent was evaporated. The crude residue was dissolved with EA (50 mL) and washed with saturated NaHCO.sub.3 solution (50 mL). Separated the organic phase and purified by pre-HPLC to give the title compound. .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.52 (d, J=13.6 Hz, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (d, J=11.2 Hz, 1H), 7.75-7.45 (m, 4H), 3.41-3.38 (m, 2H), 2.17-1.96 (m, 2H), 1.95-1.51 (m, 7H), 1.33 (d, J=6.8 Hz, 3H). [M+H].sup.+=425.8.

Example B2a and B2b: 4-((1R,4s)-4-((S)-1-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline and 4-((1S,4s)-4-((R)-1-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(290) ##STR00180##

(291) Each enantiomer of racemic B2a and B2b was separated using preparative HPLC on a CHIRALPAK IC with Hex:EtOH=90:10 as an eluent. The first one enantiomer eluted at the retention time of 3.414 min, B2a (3.81 mg), .sup.1H NMR (MeOH-d6) δ.sub.H 8.78 (d, J=4.8 Hz, 1H), 8.07 (dd, J=9.2, 5.6 Hz, 1H), 7.87 (dd, J=10.8, 2.8 Hz, 1H), 7.66-7.49 (m, 3H), 7.35 (br, 1H), 3.51-3.37 (m, 2H), 2.18-2.16 (m, 2H), 2.02-1.54 (m, 7H), 1.43 (d, J=6.8 Hz, 3H). [M+H].sup.+=425.8. And the other enantiomer eluted at the retention time of 3.881 min, B2b (43.63 mg), .sup.1H NMR (MeOH-d6) δ.sub.H 8.68 (d, J=4.8 Hz, 1H), 7.97 (dd, J=9.2, 5.6 Hz, 1H), 7.76 (dd, J=10.8, 2.8 Hz, 1H), 7.59-7.39 (m, 3H), 7.26 (br, 1H), 3.45-3.29 (m, 2H), 2.07-1.84 (m, 2H), 1.97-1.54 (m, 7H), 1.33 (d, J=6.8 Hz, 3H). [M+H].sup.+=425.8.

Example B3: methyl 2-(1-(4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxylate

(292) ##STR00181##

Step 1: methyl 3-amino-4-(2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamido)benzoate

(293) To a solution of (R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoic acid (0.2 g, 0.66 mmol) in DMF (10 mL) were added HATU (0.3 g, 0.8 mmol), DIEA (0.5 mL) at room temperature. Methyl 3,4-diaminobenzoate (0.13 g, 0.8 mmol) was added. The mixture was stirred at 50° C. for 18 hours. The reaction was then quenched with H.sub.2O (50 mL), extracted with EA (50 mL*2), separated the organic phase and washed with brine (100 mL). Concentrated the organic phase for next step directly without further purification.

Step 2: methyl 2-(1-(4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxylate

(294) ##STR00182##
A solution of methyl 3-amino-4-(2-(4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamido)benzoate in HOAc (20 mL) was stirred at 100° C. for 18 hours. The solvent was evaporated. The crude residue was dissolved with EA (50 mL) and washed with saturated NaHCO.sub.3 solution (50 mL). Separated the organic phase and purified by pre-HPLC to give the title compound. .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.60 (d, J=4.4 Hz, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.19-7.93 (m, 3H), 7.78-7.76 (m, 1H), 7.71-7.50 (m, 3H), 3.86 (d, J=1.6 Hz, 3H), 3.45-3.40 (m, 2H), 2.21-2.01 (m, 2H), 1.93-1.54 (m, 7H), 1.36 (d, J=6.0 Hz, 3H). [M+H].sup.+=431.9.

Example B3a and B3b: methyl 2-((S)-1-((1s,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxylate and methyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxylate

(295) ##STR00183##
Each enantiomer of racemic B3a and B3b was separated using preparative HPLC on a CHIRALPAK IC with Hex:EtOH=70:30 as an eluent. The first one enantiomer eluted at the retention time of 1.534 min, B3a (7.65 mg). .sup.1H NMR (MeOH-d6) δH 8.68 (d, J=4.8 Hz, 1H), 8.13 (s, 1H), 7.97 (dd, J=9.2, 5.6 Hz, 1H), 7.83-7.75 (m, 2H), 7.53-7.42 (m, 3H), 3.82 (s, 3H), 3.45-3.31 (m, 2H), 2.15-2.07 (m, 2H), 1.95-1.54 (m, 7H), 1.36 (d, J=6.8 Hz, 3H). [M+H].sup.+=431.8. And the other enantiomer eluted at the retention time of 2.048 min, B3b: (37.58 mg). .sup.1H NMR (MeOH-d6) δ.sub.H 8.77 (d, J=4.4 Hz, 1H), 8.26-8.05 (m, 2H), 7.94-7.81 (m, 2H), 7.61-7.55 (m, 3H), 3.91 (s, 3H), 3.55-3.37 (m, 2H), 2.28-2.13 (m, 2H), 2.01-1.68 (m, 7H), 1.45 (d, J=6.8 Hz, 3H). [M+H].sup.+=431.8.

Example B4 6-fluoro-4-((1S,4s)-4-((R)-1-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(296) ##STR00184##

Step 1: (R)-3-(2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)acetyl)-4-phenyloxazolidin-2-one

(297) To a solution of 2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)acetic acid in THF (35 mL) was added TEA (3.1 mL). Cooled to 0° C. and added TMAcCl (1.7 mL). Stirred at 0° C. for 30 min. To another flask were added (R)-4-phenyloxazolidin-2-one (2.4 g, 14.7 mmol) and THE (70 mL). Cooled to 0° C. and added LiHMDS (11.3 mL, 1.3 eq). The reaction mixture was added into the first flask slowly at 0° C. The mixture was stirred at 20-30° C. for 2 hours. Poured the mixture into sat. NH.sub.4Cl solution (150 mL), extracted with EA (100 mL*3). Combined the organic phase and washed with brine (100 mL). Concentrated the organic phase and purified by column chromatography on silica gel. The crude oil was slurry with MTBE to give product (3.3 g) as white solid.

Step 2: (R)-3-((S)-2-((1s,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoyl)-4-phenyloxazolidin-2-one

(298) To a solution of (R)-3-(2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)acetyl)-4-phenyloxazolidin-2-one (4.1 g, 9.5 mmol) in THF (40 mL) was added NaHMDS (5.7 mL, 11.4 mmol) at −40° C. The mixture was stirred at −40° C. for 10 min. Me (2.0 g, 14.2 mmol) was added slowly and stirred at −40° C. for 2 hours. The mixture was quenched with sat. NH.sub.4Cl solution (80 mL) and extracted with EA (50 mL*3). Combined the organic phase and washed with brine (100 mL). Concentrated the organic phase and purified by column chromatography on silica gel to give product (3.3 g) as white solid.

Step 3: (R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoic acid

(299) To a solution of (R)-3-((S)-2-((1s,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoyl)-4-phenyloxazolidin-2-one (2.9 g, 6.5 mmol) in THE (21.6 mL) were added H.sub.2O (2.9 mL), LiOH.H.sub.2O (0.4 g, 10.6 mmol) in H.sub.2O (6.7 mL) at 0° C. The mixture was stirred at 20-30° C. for 18 hours. The reaction mixture was cooled to 0° C. and added sat. NaHSO.sub.3 solution (8.8 mL). Evaporated the organic phase and added HOAc (1.2 mL) and EA (20 mL). Separated the organic phase and extracted the aqueous phase with EA (20 mL*2). Combined the organic phase and concentrated. Crystallized with MeCN (14 mL) and washed the filter cake with MeCN (10 mL). Dried the filter cake under reduced pressure to give product (1.6 g) as white solid. .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H: 12.11 (d, J=3.2 Hz, 1H), 8.82 (s, 1H), 8.15-7.89 (m, 2H), 7.82-7.42 (m, 2H), 3.39 (br, 1H), 2.72 (br, 1H), 1.83-1.68 (m, 9H), 1.10 (br, 3H).

Step 4: (R)—N-(2-amino-4-(trifluoromethyl)phenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide

(300) To a solution of (R)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanoic acid (0.2 g, 0.66 mmol) in DMF (10 mL) were added HATU (0.3 g, 0.8 mmol), DIEA (0.5 mL) at room temperature. 4-(trifluoromethyl)benzene-1,2-diamine (0.14 g, 0.8 mmol) was added. The mixture was stirred at 50° C. for 18 hours. The reaction was then quenched with H.sub.2O (50 mL), Extracted with EA (50 mL*2), Separated the organic phase and washed with brine (100 mL). Concentrated the organic phase for next step directly without further purification.

Step 5: 6-fluoro-4-((1S,4s)-4-((R)-1-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(301) ##STR00185##

(302) A solution of (R)—N-(2-amino-4-(trifluoromethyl)phenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide in HOAc (20 mL) was stirred at 80° C. for 18 hours. The solvent was evaporated. The crude residue was dissolved with EA (50 mL) and washed with saturated NaHCO.sub.3 solution (50 mL). Separated the organic phase and purified by pre-HPLC to give the title compound.

(303) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.66 (s, 1H), 8.85 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=11.2, 2.4 Hz, 1H), 7.85 (s, 1H), 7.68-7.64 (m, 2H), 7.57-756 (m, 1H), 7.44 (d, J=8.4 Hz, 1H), 3.51-3.41 (m, 2H), 2.16-2.05 (m, 2H), 1.96-1.49 (m, 7H), 1.37 (d, J=6.8 Hz, 3H). [M+H].sup.+=441.8.

(304) Compounds B5 to B148 were prepared in a procedure similar to Example B1a.

Example B5: 6-fluoro-4-((1S,4s)-4-((R)-1-(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(305) ##STR00186##

(306) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 13.07-13.36 (m, 1H), 8.84 (d, J=4.4 Hz, 1H), 8.08 (dd, J=9.2, 6.0 Hz, 1H), 7.96 (dd, J=10.8, 2.4 Hz, 1H), 7.61-7.69 (m, J=9.2, 2.4 Hz, 1H), 7.56 (d, J=4.4 Hz, 1H), 7.16-7.32 (m, 1H), 3.35-3.47 (m, 2H), 2.11-2.21 (m, 1H), 1.98-2.07 (m, J=12.8 Hz, 1H), 1.81-1.92 (m, 2H), 1.69-1.80 (m, 2H), 1.49-1.69 (m, 2H), 1.34 (d, J=6.8 Hz, 3H), 1.08-1.18 (m, 1H).

Example B6: 6-fluoro-4-((1S,4s)-4-((R)-1-(4,5,6-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(307) ##STR00187##

Example B7: 4-((1S,4s)-4-((R)-1-(5,6-difluoro-4-methyl-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(308) ##STR00188##

Example B8: 2-((S)-1-((1s,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carbonitrile

(309) ##STR00189##

(310) .sup.1H NMR (400 MHz, DMSO-d6) δH 12.85 (s, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.10 (m, 1H), 8.05 (s, 1H), 7.98 (m, 1H), 7.67 (m, 2H), 7.55 (m, 2H), 3.47 (m, 2H), 2.16 (m, 1H), 2.05 (m, 1H), 1.88 (m, 2H), 1.79 (m, 2H), 1.65 (m, 1H), 1.56 (m, 1H), 1.37 (d, J=6.8 Hz, 3H), 1.15 (m, 1H).

Example B9: 6-fluoro-4-((1S,4s)-4-((R)-1-(5-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(311) ##STR00190##

Example B10: 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(312) ##STR00191##

Example B11: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-methyl-1H-benzo[d]imidazole-5-carboxamide

(313) ##STR00192##

(314) .sup.1H NMR (400 MHz, cd3od) δ.sub.H 8.79 (d, J=4.7 Hz, 1H), 8.09-8.06 (m, 2H), 7.89-7.86 (m, 1H), 7.77-7.46 (m, 4H), 3.56-3.39 (m, 2H), 2.94 (s, 3H), 2.28-2.14 (m, 2H), 2.00-1.90 (m, 4H), 1.78-1.69 (m, 2H), 1.47-1.45 (m, 3H), 1.31 (d, J=12.1 Hz, 1H).

Example B12: 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide

(315) ##STR00193##

Example B13: aziridin-1-yl(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)methanone

(316) ##STR00194##

Example B14: N-cyclopropyl-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(317) ##STR00195##

Example B15: azetidin-1-yl(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)methanone

(318) ##STR00196##

Example B16: (2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)(3-hydroxyazetidine-1-yl)methanone

(319) ##STR00197##

Example B17: ethyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxylate

(320) ##STR00198##

Example B18: isopropyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxylate

(321) ##STR00199##

Example B19: 5-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)oxazole

(322) ##STR00200##

Example B20: 6-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazole

(323) ##STR00201##

Example B21: 3-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)-1,2,4-oxadiazole

(324) ##STR00202##

Example B22: 4-((1S,4s)-4-((R)-1-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(325) ##STR00203##

Example B23: 1-((6-fluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)oxy)propan-2-ol

(326) ##STR00204##

Example B24: 6-fluoro-4-((1S,4s)-4-((R)-1-(6-fluoro-5-(2-methoxyethoxy)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(327) ##STR00205##

Example B25a and B25b: (S)-3-(4-(1-(6-chloro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline or (R)-3-(4-(1-(6-chloro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(328) ##STR00206##

(329) Example B25a .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.39 (s, 1H), 8.82 (d, J=2.0 Hz, 1H), 8.11 (m, 1H), 7.96 (d, J=8.4 Hz, 1H), 7.91 (d, J=7.6 Hz, 1H), 7.68 (m, 1H), 7.54 (m, 3H), 7.15 (dd, J=8.4, 2.0 Hz, 1H), 2.90 (m, 1H), 2.69 (m, 1H), 1.98 (d, J=11.2 Hz, 2H), 1.85 (m, 2H), 1.57 (m, 3H), 1.36 (d, J=7.2 Hz, 3H), 1.23 (m, 3H).

(330) Example B25b .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.41 (s, 1H), 8.89 (d, J=2.0 Hz, 1H), 8.22 (s, 1H), 7.98 (dd, J=12.0, 8.4 Hz, 2H), 7.70 (t, J=7.2 Hz, 1H), 7.56 (m, 3H), 7.14 (dd, J=8.4, 1.6 Hz, 1H), 3.36 (m, 1H), 2.88 (m, 1H), 2.05 (m, 1H), 1.93 (m, 3H), 1.76 (m, 2H), 1.61 (m, 1H), 1.45 (m, 1H), 1.33 (d, J=6.8 Hz, 3H), 1.16 (m, 1H).

Example B26: 4-((1S,4s)-4-((R)-cyclopropyl(5,6-difluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(331) ##STR00207##

Example B27: 4-((1S,4s)-4-((R)-cyclopropyl(5,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(332) ##STR00208##

Example B28: methyl 2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole-5-carboxylate

(333) ##STR00209##

Example B29: 4-((1S,4s)-4-((R)-(5-chloro-1H-benzo[d]imidazol-2-yl)(cyclopropyl)methyl)cyclohexyl)-6-fluoroquinoline

(334) ##STR00210##

Example B30: 4-((1S,4s)-4-((R)-cyclopropyl(5-fluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)-6-fluoroquinoline

(335) ##STR00211##

Example B31: 4-((1S,4s)-4-((R)-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)(cyclopropyl)methyl)cyclohexyl)-6-fluoroquinoline

(336) ##STR00212##

Example B32:2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide

(337) ##STR00213##

Example B33: 2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole-5-carboxamide

(338) ##STR00214##

Example B34: aziridin-1-yl(2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazol-5-yl)methanone

(339) ##STR00215##

Example B35: N-cyclopropyl-2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole-5-carboxamide

(340) ##STR00216##

Example B36: 2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-N-methyl-1H-benzo[d]imidazole-5-carboxamide

(341) ##STR00217##

Example B37: N-cyclobutyl-2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazole-5-carboxamide

(342) ##STR00218##

Example B38: 2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-N-(3-hydroxycyclobutyl)-1H-benzo[d]imidazole-5-carboxamide

(343) ##STR00219##

Example B39: azetidin-1-yl(2-(R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazol-5-yl)methanone

(344) ##STR00220##

Example B40: (2-((R)-cyclopropyl((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)methyl)-1H-benzo[d]imidazol-5-yl)(piperidin-1-yl)methanone

(345) ##STR00221##

Example B41: 4-((1S,4s)-4-((R)-1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)cyclohexyl)-6-fluoroquinoline

(346) ##STR00222##

Example B42: methyl 2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxylate

(347) ##STR00223##

Example B43: 4-((1S,4s)-4-((R)-1-(5-chloro-H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)cyclohexyl)-6-fluoroquinoline

(348) ##STR00224##

Example B44: 6-fluoro-4-((1S,4s)-4-((R)-2,2,2-trifluoro-1-(5-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(349) ##STR00225##

Example B45: 4-((1S,4s)-4-((R)-1-(6-chloro-5-fluoro-H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)cyclohexyl)-6-fluoroquinoline

(350) ##STR00226##

Example B46: N,N-dimethyl-2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(351) ##STR00227##

Example B47: 2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(352) ##STR00228##

Example B48: aziridin-1-yl(2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)methanone

(353) ##STR00229##

Example B49: N-cyclopropyl-2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(354) ##STR00230##

Example B50: N-methyl-2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(355) ##STR00231##

Example B51: N-cyclobutyl-2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(356) ##STR00232##

Example B52: N-(3-hydroxycyclobutyl)-2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(357) ##STR00233##

Example B53: 6-fluoro-4-((1S,4s)-4-((R)-2,2,2-trifluoro-1-(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(358) ##STR00234##

Example B54: 6-fluoro-4-((1S,4s)-4-((R)-2,2,2-trifluoro-1-(5,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(359) ##STR00235##

Example B55: 4-((1S,4s)-4-((R)-1-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)cyclohexyl)-6-fluoroquinoline

(360) ##STR00236##

Example B56: azetidin-1-yl(2-((R)-2,2,2-trifluoro-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)methanone

(361) ##STR00237##

Example B57: (R)-4-(4-(1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperazin-1-yl)-6-fluoroquinoline

(362) ##STR00238##

Example B58: (R)-6-fluoro-4-(4-(1-(6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperazin-1-yl)quinoline

(363) ##STR00239##

Example B59: (R)-4-(4-(1-(6-chloro-1H-benzo[d]imidazol-2-yl)ethyl)piperazin-1-yl)-6-fluoroquinoline

(364) ##STR00240##

Example B60: (R)-4-(4-(1-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperazin-1-yl)-6-fluoroquinoline

(365) ##STR00241##

Example B61: (R)-4-(4-(1-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)ethyl)piperazin-1-yl)-6-fluoroquinoline

(366) ##STR00242##

Example B62: methyl (R)-2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(367) ##STR00243##

Example B63: (R)-2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(368) ##STR00244##

Example B64: (R)-2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-N-methyl-1H-benzo[d]imidazole-6-carboxamide

(369) ##STR00245##

Example B65: (R)-2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-N,N-dimethyl-1H-benzo[d]imidazole-6-carboxamide

(370) ##STR00246##

Example B66: (R)-aziridin-1-yl(2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-6-yl)methanone

(371) ##STR00247##

Example B67: (R)-azetidin-1-yl(2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-6-yl)methanone

(372) ##STR00248##

Example B68: (R)—N-cyclobutyl-2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(373) ##STR00249##

Example B69: (R)-2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-N-(3-hydroxycyclobutyl)-1H-benzo[d]imidazole-6-carboxamide

(374) ##STR00250##

Example B70: (R)—N-cyclohexyl-2-(1-(4-(6-fluoroquinolin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(375) ##STR00251##

Example B71: (R)-4-(1-(cyclopropyl(5,6-difluoro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-4-yl)-6-fluoroquinoline

(376) ##STR00252##

Example B72: (R)-4-(1-(cyclopropyl(6-fluoro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-4-yl)-6-fluoroquinoline

(377) ##STR00253##

Example B73: (R)-4-(1-((6-chloro-1H-benzo[d]imidazol-2-yl)(cyclopropyl)methyl)piperidin-4-yl)-6-fluoroquinoline

(378) ##STR00254##

Example B74: (R)-4-(1-((6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)(cyclopropyl)methyl)piperidin-4-yl)-6-fluoroquinoline

(379) ##STR00255##

Example B75: (R)-4-(1-(cyclopropyl(4,5,6-trifluoro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-4-yl)-6-fluoroquinoline

(380) ##STR00256##

Example B76: (R)-4-(1-(cyclopropyl(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)methyl)piperidin-4-yl)-6-fluoroquinoline

(381) ##STR00257##

Example B77: (R)-4-(1-(cyclopropyl(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)methyl)piperidin-4-yl)-6-fluoroquinoline

(382) ##STR00258##

Example B78: (R)-4-(1-((7-chloro-5,6-difluoro-1H-benzo[d]imidazol-2-yl)(cyclopropyl)methyl)piperidin-4-yl)-6-fluoroquinoline

(383) ##STR00259##

Example B79: (R)-2-(cyclopropyl(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)methyl)-N,N-dimethyl-1H-benzo[d]imidazole-6-carboxamide

(384) ##STR00260##

Example B80: (R)-2-(cyclopropyl(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)methyl)-N-methyl-1H-benzo[d]imidazole-6-carboxamide

(385) ##STR00261##

Example B81: (R)-(2-(cyclopropyl(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)methyl)-1H-benzo[d]imidazol-6-yl)(3-hydroxyazetidin-1-yl)methanone

(386) ##STR00262##

Example B82: (R)—N-cyclopropyl-2-(cyclopropyl(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)methyl)-1H-benzo[d]imidazole-6-carboxamide

(387) ##STR00263##

Example B83: (S)-4-(1-(1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)piperidin-4-yl)-6-fluoroquinoline

(388) ##STR00264##

Example B84: (S)-6-fluoro-4-(1-(2,2,2-trifluoro-1-(6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)quinoline

(389) ##STR00265##

Example B85: (S)-4-(1-(1-(6-chloro-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)piperidin-4-yl)-6-fluoroquinoline

(390) ##STR00266##

Example B86: (S)-4-(1-(1-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)piperidin-4-yl)-6-fluoroquinoline

(391) ##STR00267##

Example B87: (S)-6-fluoro-4-(1-(2,2,2-trifluoro-1-(4,5,6-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)quinoline

(392) ##STR00268##

Example B88: (S)-6-fluoro-4-(1-(2,2,2-trifluoro-1-(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)quinoline

(393) ##STR00269##

Example B89: (S)-4-(1-(1-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)piperidin-4-yl)-6-fluoroquinoline

(394) ##STR00270##

Example B90: (S)-4-(1-(1-(7-chloro-5,6-difluoro-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoroethyl)piperidin-4-yl)-6-fluoroquinoline

(395) ##STR00271##

Example B91: (S)—N,N-dimethyl-2-(2,2,2-trifluoro-1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(396) ##STR00272##

Example B92: (S)—N-methyl-2-(2,2,2-trifluoro-1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-1H-benzo[d]imidazole-6 carboxamide

(397) ##STR00273##

Example B93: (S)-(3-hydroxyazetidin-1-yl)(2-(2,2,2-trifluoro-1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-6-yl)methanone

(398) ##STR00274##

Example B94: (S)—N-cyclopropyl-2-(2,2,2-trifluoro-1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(399) ##STR00275##

Example B95:6-fluoro-4-((1S,4s)-4-((R)-methoxy(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(400) ##STR00276##

Example B96: 4-((1S,4s)-4-((R)-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)(methoxy)methyl)cyclohexyl)-6-fluoroquinoline

(401) ##STR00277##

Example B97: 6-fluoro-4-((1S,4s)-4-((R)-methoxy(5,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)methyl)cyclohexyl)quinoline

(402) ##STR00278##

Example B98: 4-((1S,4s)-4-((R)-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)(methoxy)methyl)cyclohexyl)-6-fluoroquinoline

(403) ##STR00279##

Example B99: methyl 2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-1H-benzo[d]imidazole-5-carboxylate

(404) ##STR00280##

Example B100: 4-((1S,4s)-4-((R)-(5-chloro-1H-benzo[d]imidazol-2-yl)(methoxy)methyl)cyclohexyl)-6-fluoroquinoline

(405) ##STR00281##

Example B101: 6-fluoro-4-((1S,4s)-4-((R)-(5-fluoro-1H-benzo[d]imidazol-2-yl)(methoxy)methyl)cyclohexyl)quinoline

(406) ##STR00282##

Example B102: 4-((1S,4s)-4-((R)-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)(methoxy)methyl)cyclohexyl)-6-fluoroquinoline

(407) ##STR00283##

Example B103: 2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide

(408) ##STR00284##

Example B104: 2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-1H-benzo[d]imidazole-5-carboxamide

(409) ##STR00285##

Example B105: aziridin-1-yl(2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-1H-benzo[d]imidazol-5-yl)methanone

(410) ##STR00286##

Example B106: N-cyclopropyl-2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-1H-benzo[d]imidazole-5-carboxamide

(411) ##STR00287##

Example B107: 2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-N-methyl-1H-benzo[d]imidazole-5-carboxamide

(412) ##STR00288##

Example B108: N-cyclobutyl-2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl 1H-benzo[d]imidazole-5-carboxamide

(413) ##STR00289##

Example B109: 2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-N-(3-hydroxycyclobutyl)-1H-benzo[d]imidazole-5-carboxamide

(414) ##STR00290##

Example B110: azetidin-1-yl(2-((R)-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)(methoxy)methyl)-1H-benzo[d]imidazol-5-yl)methanone

(415) ##STR00291##

Example B111: (R)-4-(1-(1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)-6-fluoroquinoline

(416) ##STR00292##

Example B112: (R)-6-fluoro-4-(1-(1-(6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)quinoline

(417) ##STR00293##

Example B113: (R)-4-(1-(1-(6-chloro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)-6-fluoroquinoline

(418) ##STR00294##

Example B114: (R)-4-(1-(1-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)-6-fluoroquinoline

(419) ##STR00295##

Example B115: (R)-6-fluoro-4-(1-(1-(4,5,6-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)quinoline

(420) ##STR00296##

Example B116: (R)-6-fluoro-4-(1-(1-(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)quinoline

(421) ##STR00297##

Example B117: (R)-4-(1-(1-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)-6-fluoroquinoline

(422) ##STR00298##

Example B118: (R)-4-(1-(1-(7-chloro-5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)piperidin-4-yl)-6-fluoroquinoline

(423) ##STR00299##

Example B119: (R)-2-(1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-N,N-dimethyl-1H-benzo[d]imidazole-6-carboxamide

(424) ##STR00300##

Example B120: (R)-2-(1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-N-methyl-1H-benzo[d]imidazole-6-carboxamide

(425) ##STR00301##

Example B121: (R)-(2-(1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-6-yl)(3-hyroxyazetidin-1-yl)methanone

(426) ##STR00302##

Example B122: (R)—N-cyclopropyl-2-(1-(4-(6-fluoroquinolin-4-yl)piperidin-1-yl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(427) ##STR00303##

Example B123: 4-((1S,4s)-4-((R)-1-(4-chloro-5,7-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(428) ##STR00304##

Example B124: 4-((1S,4s)-4-((R)-1-(7-chloro-4,5-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(429) ##STR00305##

Example B125: 4-((1S,4s)-4-((R)-1-(4-chloro-5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(430) ##STR00306##

Example B126: ethyl 4-chloro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(431) ##STR00307##

Example B127: ethyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-4-methyl-1H-benzo[d]imidazole-6-carboxylate

(432) ##STR00308##

Example B128: ethyl 4-fluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(433) ##STR00309##

Example B129: ethyl 7-fluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(434) ##STR00310##

Example B130: ethyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-7-methyl-1H-benzo[d]imidazole-6-carboxylate

(435) ##STR00311##

Example B131: ethyl 5,7-difluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(436) ##STR00312##

Example B132: ethyl 5-fluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(437) ##STR00313##

Example B133: tert-butyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(438) ##STR00314##

Example B134: cyclobutyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(439) ##STR00315##

Example B135: 3-hydroxycyclobutyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(440) ##STR00316##

Example B136: N-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)methanesulfonamide

(441) ##STR00317##

Example B137: 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-sulfonamide

(442) ##STR00318##

Example B138: 6-fluoro-4-((1S,4s)-4-((R)-1-(6-(methylsulfonyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(443) ##STR00319##

Example B139: 1-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)ethanone

(444) ##STR00320##

Example B140: methyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-7-methyl-1H-benzo[d]imidazole-6-carboxylate

(445) ##STR00321##

Example B141: methyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-4-methyl-1H-benzo[d]imidazole-6-carboxylate

(446) ##STR00322##

Example B142: methyl 4-fluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(447) ##STR00323##

Example B143: methyl 7-fluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(448) ##STR00324##

Example B144: methyl 2-(1-cyano-1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-7-fluoro-1H-benzo[d]imidazole-6-carboxylate

(449) ##STR00325##

Example B145: methyl 2-(1-cyano-1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-7-methyl-1H-benzo[d]imidazole-6-carboxylate

(450) ##STR00326##

Example B146: methyl 2-(1-cyano-1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylate

(451) ##STR00327##

Example B147:2-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanenitrile

(452) ##STR00328##

Example B148: N-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)acetamide

(453) ##STR00329##

Example B151: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

(454) ##STR00330##

(455) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.68 (m, 1H), 11.95 (s, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.15-8.26 (m, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (m, 2H), 7.60-7.79 (m, 2H), 7.60 (d, J=4.4 Hz, 1H), 3.47 (m, 2H), 2.19 (m, 1H), 2.06 (m, 1H), 1.86 (m, 3H), 1.78 (m, 1H), 1.67 (m, 1H), 1.58 (m, 1H), 1.38 (m, 3H), 1.19 (m, 1H).

Example B157: 6-fluoro-4-((1S,4s)-4-((R)-1-(5-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(456) ##STR00331##

(457) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 8.88 (t, J=4.9 Hz, 3H), 8.56 (s, 1H), 8.32 (d, J=8.6 Hz, 1H), 8.10 (dd, J=9.3, 5.8 Hz, 1H), 7.99 (dd, J=11.0, 2.6 Hz, 1H), 7.71-7.58 (m, 3H), 7.39 (t, J=4.8 Hz, 1H), 3.50-3.41 (m, 2H), 2.20-1.57 (m, 9H), 1.40 (d, J=6.9 Hz, 3H), 1.21 (m, 1H).

Example B159: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1,5,7,8-tetrahydro-6H-imidazo[4,5-g]quinolin-6-one

(458) ##STR00332##

(459) 1H NMR (400 MHz, DMSO-d6) δ.sub.H 11.95-12.00 (m, 1H), 9.98 (m, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.97 (d, J=8.8 Hz, 1H), 7.67 (t, J=8.4 Hz, 1H), 7.57 (d, J=4.4 Hz, 1H), 7.25 (m, 1H), 6.98 (m, 1H), 3.41 (m, 1H), 3.30 (m, 1H), 2.92 (s, 2H), 2.41 (m, 2H), 2.09 (m, 2H), 1.81 (m, 4H), 1.59 (m, 2H), 1.32 (d, J=6.8 Hz, 3H), 1.17 (m, 1H).

Example B160: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide

(460) ##STR00333##

(461) 1H NMR (400 MHz, cd3od) δ.sub.H 8.69 (d, J=4.7 Hz, 1H), 7.98 (dd, J=9.2, 5.6 Hz, 1H), 7.79 (dd, J=10.6, 2.6 Hz, 1H), 7.62-7.44 (m, 3H), 7.21 (d, J=8.3 Hz, 1H), 3.48-3.28 (m, 2H), 3.03 (s, 3H), 2.96 (s, 3H), 2.16-2.09 (m, 2H), 2.00-1.73 (m, 4H), 1.66-1.60 (m, 2H), 1.37 (d, J=6.8 Hz, 3H), 1.22 (d, J=11.8 Hz, 1H).

Example B163: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxylic acid

(462) ##STR00334##

(463) 1H NMR (400 MHz, dmso) δ 12.55 (s, 2H), 8.86 (d, J=4.3 Hz, 1H), 8.09 (dd, J=9.1, 6.0 Hz, 2H), 7.98 (d, J=10.3 Hz, 1H), 7.76 (s, 1H), 7.66 (t, J=7.6 Hz, 1H), 7.59 (d, J=4.2 Hz, 2H), 3.42 (s, 2H), 2.16-2.03 (m, 2H), 1.95-1.71 (m, 4H), 1.69-1.50 (m, 2H), 1.36 (d, J=6.6 Hz, 3H), 1.24-1.16 (m, 1H).

Example B164 N-cyclobutyl-2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(464) ##STR00335##

(465) 1H NMR (400 MHz, DMSO-d) δ.sub.H 12.43 (s, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.52 (s, 1H), 8.12-8.08 (m, 1H), 7.98 (dd, J=11.0, 2.6 Hz, 1H), 7.69-7.64 (m, 2H), 7.59-7.47 (m, 2H), 4.44 (dd, J=16.3, 8.2 Hz, 1H), 3.45-3.41 (m, Hz, 2H), 2.28-1.98 (m, 6H), 1.95-1.73 (m, 4H), 1.72-1.52 (m, 4H), 1.36 (d, J=6.8 Hz, 3H), 1.17 (d, J=12.4 Hz, 1H).

Example B165: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-methoxy-1H-benzo[d]imidazole-6-carboxamide

(466) ##STR00336##

(467) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.52 (s, 1H), 11.64 (s, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 5.8 Hz, 1H), 7.98 (dd, J=11.0, 2.4 Hz, 1H), 7.91 (s, 1H), 7.67 (dd, J=11.6, 5.6 Hz, 1H), 7.62-7.46 (m, 3H), 3.72 (s, 3H), 3.46-3.41 (m, 6.6 Hz, 2H), 2.16-2.03 (m, 2H), 1.96-1.71 (m, 4H), 1.67-1.55 (m, 2H), 1.36 (d, J=6.7 Hz, 3H), 1.17-1.14 (m, 1H).

Example B166: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-naphtho[2,3-d]imidazole

(468) ##STR00337##

(469) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.32 (s, 1H), 8.85-8.93 (m, 1H), 8.07-8.14 (m, 1H), 7.94-8.02 (m, 4H), 7.67 (t, J=8.8 Hz, 1H), 7.58-7.63 (m, 1H), 7.31-7.43 (m, 2H), 3.39-3.55 (m, 2H), 2.16-2.29 (m, 1H), 2.04-2.14 (m, 1H), 1.53-1.96 (m, 6H), 1.41 (d, J=6.4 Hz, 3H), 1.22-1.29 (m, 1H).

Example B167: 6-fluoro-4-((1s,4s)-4-(1-(6-(methylsulfonyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(470) ##STR00338##

(471) .sup.1H NMR (400 MHz, CDCl.sub.3) δ.sub.H 8.82 (s, 1H), 8.30-8.41 (m, 1H), 8.24 (s, 1H), 7.71-7.94 (m, 4H), 7.61 (t, J=8.0 Hz, 1H), 3.62-3.71 (m, 1H), 3.36-3.43 (m, 1H), 3.08 (s, 3H), 2.40-2.43 (m, 1H), 2.06-2.21 (m, 2H), 1.87-2.01 (m, 3H), 1.69-1.82 (m, 2H), 1.56 (d, J=6.0 Hz, 3H).

Example B169: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-amine

(472) ##STR00339##

(473) 1H NMR (400 MHz, DMSO-d6) δ.sub.H 8.85 (d, J=4.4 Hz, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.97 (d, J=11.2 Hz, 1H), 7.66 (t, J=8.8 Hz, 1H), 7.56 (d, J=4.0 Hz, 1H), 7.13 (d, J=8.4 Hz, 1H), 6.61 (s, 1H), 6.44 (d, J=8.4 Hz, 1H), 5.76 (s, 1H), 4.84 (s, 1H), 3.37-3.45 (m, 1H), 3.20-3.29 (m, 1H), 1.96-2.14 (m, 2H), 1.81-1.92 (m, 2H), 1.71-1.80 (m, 2H), 1.52-1.67 (m, 2H), 1.30 (d, J=6.8 Hz, 3H), 1.16-1.21 (m, 1H).

Example B170: N-cyclopentyl-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(474) ##STR00340##

(475) 1H NMR (400 MHz, DMSO-d) δ.sub.H 12.41 (s, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.18 (s, 1H), 8.09 (dd, J=9.1, 5.9 Hz, 1H), 7.98 (dd, J=11.0, 2.4 Hz, 1H), 7.69-7.65 (m, 2H), 7.58 (d, J=4.4 Hz, 1H), 7.53-7.45 (m, 1H), 4.24 (dd, J=13.6, 6.8 Hz, 1H), 3.52-3.37 (m, 2H), 2.16-2.13 (m, 1H), 2.06-1.99 (m, 1H), 1.94-1.62 (m, 9H), 1.60-1.53 (m, 5H), 1.36 (d, J=6.8 Hz, 3H), 1.17-1.14 (m, 1H).

Example B171: N-cyclohexyl-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(476) ##STR00341##

(477) 1H NMR (400 MHz, DMSO-d) δ.sub.H 8.90 (d, J=4.5 Hz, 1H), 8.33 (d, J=7.6 Hz, 1H), 8.19-8.06 (m, 2H), 8.01 (dd, J=10.9, 2.2 Hz, 1H), 7.90 (d, J=8.4 Hz, 1H), 7.79-7.65 (m, 2H), 7.62 (d, J=4.5 Hz, 1H), 3.78 (s, 1H), 3.68-3.64 (m, 1H), 3.45 (s, 1H), 2.21-2.18 (m, 1H), 2.08-2.05 (m, 1H), 1.95-1.71 (m, 9H), 1.63-1.57 (m, 2H), 1.46 (d, J=6.7 Hz, 3H), 1.32-1.23 (m, 4H), 1.17-1.04 (m, 2H).

Example B172: 4-((1s,4s)-4-(1-(7-chloro-4,5-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(478) ##STR00342##

(479) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.96-13.40 (m, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=11.2, 2.4 Hz, 1H), 7.67 (td, J=9.0, 2.8 Hz, 1H), 7.59 (d, J=4.4 Hz, 1H), 7.37-7.50 (m, 1H), 3.38-3.54 (m, 2H), 2.15-2.27 (m, 1H), 2.00-2.09 (m, 1H), 1.84-1.94 (m, 2H), 1.73-1.81 (m, 2H), 1.62-1.72 (m, 1H), 1.52-1.61 (m, 1H), 1.36 (d, J=6.8 Hz, 3H), 1.09-1.20 (m, 1H).

Example B173: 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-naphtho[2,3-d]imidazole

(480) ##STR00343##

(481) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.79 (s, 1H), 8.81-8.94 (m, 1H), 8.25-8.44 (m, 1H), 8.06-8.17 (m, 1H), 7.94-8.04 (m, 2H), 7.53-7.76 (m, 5H), 7.36-7.48 (m, 1H), 3.40-3.45 (m, 1H), 3.13 (d, J=4.80 Hz, 2H), 1.85-2.01 (m, 4H), 1.65-1.79 (m, 4H).

Example B174: N-cyclobutyl-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

(482) ##STR00344##

(483) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.46 (s, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.53 (s, 1H), 8.10 (dd, J=9.2, 5.8 Hz, 1H), 8.02-7.93 (m, 1H), 7.69-7.64 (m, 2H), 7.59 (d, J=4.3 Hz, 1H), 7.50 (s, 1H), 4.44 (dd, J=16.0, 7.9 Hz, 1H), 3.45-3.39 (m, 2H), 2.28-2.00 (m, 7H), 1.96-1.74 (m, 4H), 1.71-1.50 (m, 4H), 1.36 (d, J=6.8 Hz, 3H), 1.16 (d, J=11.7 Hz, 1H).

Example B178: 6-fluoro-4-((1R,4r)-4-((R)-1-(6-(methylsulfonyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)quinoline

(484) ##STR00345##

(485) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 9.52 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.05-8.16 (m, 1H), 7.95-8.02 (m, 1H), 7.63-7.70 (m, 1H), 7.59 (d, J=4.4 Hz, 1H), 7.49 (d, J=8.4 Hz, 1H), 7.41 (s, 1H), 7.08 (d, J=8.4 Hz, 1H), 3.39-3.45 (m, 2H), 2.91 (s, 3H), 2.11-2.17 (m, 1H), 2.01-2.07 (m, 1H), 1.85-1.94 (m, 2H), 1.73-1.82 (m, 2H), 1.54-1.68 (m, 2H), 1.36 (d, J=6.8 Hz, 3H), 1.13-1.20 (m, 1H).

Example B179: N-(2-((R)-1-((1r,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)acetamide

(486) ##STR00346##

(487) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.08 (s, 1H), 9.87 (s, 1H), 8.85 (d, J=4.4 Hz, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.83-8.02 (m, 2H), 7.61-7.71 (m, 1H), 7.57 (d, J=4.4 Hz, 1H), 7.38 (s, 1H), 7.05-7.22 (m, 1H), 3.37-3.48 (m, 2H), 2.07-2.14 (m, 1H), 1.98-2.06 (m, 4H), 1.83-1.94 (m, 2H), 1.70-1.81 (m, 2H), 1.52-1.64 (m, 2H), 1.33 (d, J=6.8 Hz, 3H), 1.18-1.24 (m, 1H).

Example B180: N-(2-((R)-1-((1r,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)methanesulfonamide

(488) ##STR00347##

(489) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.72-12.87 (m, 1H), 8.78-8.90 (m, 1H), 7.92-8.14 (m, 3H), 7.64-7.78 (m, 3H), 7.59 (d, J=4.4 Hz, 1H), 3.41-3.52 (m, 2H), 3.17-3.22 (m, 3H), 2.14-2.20 (m, 1H), 2.03-2.09 (m, 1H), 1.85-1.93 (m, 2H), 1.71-1.83 (m, 2H), 1.62-1.69 (m, 1H), 1.54-1.60 (m, 1H), 1.37 (d, J=6.8 Hz, 3H), 1.13-1.18 (m, 1H).

Example B182: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-phenyl-1H-benzo[d]imidazole-5-carboxamide

(490) ##STR00348##

(491) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.53 (d, J=20.5 Hz, 1H), 10.18 (d, J=16.3 Hz, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.28-7.93 (m, 3H), 7.84-7.73 (m, 3H), 7.71-7.50 (m, 3H), 7.34 (t, J=7.5 Hz, 2H), 7.08 (t, J=7.2 Hz, 1H), 3.44 (m, 2H), 2.22-1.52 (m, 8H), 1.38 (d, J=6.7 Hz, 3H), 1.23 (m, 1H).

Example B183: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-((1-hydroxycyclobutyl)methyl)-1H-benzo[d]imidazole-5-carboxamide

(492) ##STR00349##

(493) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.32 (s, 1H), 8.79 (d, J=4.6 Hz, 1H), 8.07 (dd, J=9.0, 5.9 Hz, 1H), 7.98 (m, 2H), 7.66 (m, 2H), 7.43 (m, 2H), 4.90 (s, 1H), 4.17 (d, J=10.8 Hz, 1H), 3.98 (d, J=8.8 Hz, 1H), 3.55 (d, J=16.7 Hz, 1H), 2.98-2.87 (m, 2H), 1.95-1.50 (m, 6H), 1.38 (d, J=6.8 Hz, 3H)

Example B184: 2-(1-((1r,4r)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-((1-hydroxycyclobutyl)methyl)-1H-benzo[d]imidazole-5-carboxamide

(494) ##STR00350##

(495) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.46 (s, 1H), 8.85 (d, J=4.3 Hz, 1H), 8.09 (dd, J=9.0, 5.9 Hz, 1H), 8.03-7.89 (m, 2H), 7.76-7.61 (m, 2H), 7.57 (d, J=4.0 Hz, 1H), 7.45 (dd, J=35.0, 8.4 Hz, 1H), 4.96-4.84 (m, 2H), 4.17 (d, J=10.6 Hz, 1H), 3.98 (d, J=10.7 Hz, 1H), 3.55 (d, J=16.8 Hz, 1H), 3.47-3.39 (m, 2H), 3.34 (d, J=5.4 Hz, 2H), 3.25 (d, J=16.9 Hz, 1H), 2.09 (m, 2H), 1.95-1.50 (m, 6H), 1.35 (d, J=6.6 Hz, 3H), 1.17 (m, 1H).

Example B185: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-(4-methoxycyclohexyl)-1H-benzo[d]imidazole-5-carboxamide

(496) ##STR00351##

(497) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.41 (ds, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.17-7.90 (m, 4H), 7.70-7.42 (m, 4H), 3.77 (m, 1H), 3.42 (m, 2H), 3.24 (s, 3H), 3.11 (m, 1H), 2.18-1.52 (m, 14H), 1.36 (d, J=6.6 Hz, 3H), 1.23 (m, 1H).

Example B186: 2-(1-((1r,4r)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-(4-methoxycyclohexyl)-1H-benzo[d]imidazole-5-carboxamide

(498) ##STR00352##

(499) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.41 (ds, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.17-7.90 (m, 4H), 7.70-7.42 (m, 4H), 3.77 (m, 1H), 3.42 (m, 2H), 3.24 (s, 3H), 3.11 (m, 1H), 2.18-1.52 (m, 14H), 1.36 (d, J=6.6 Hz, 3H), 1.23 (m, 1H).

Example B189 and Example B190: 4-((1R,4s)-4-((S)-1-(7-chloro-5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline and 4-((1R,4r)-4-((R)-1-(7-chloro-5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(500) ##STR00353##

(501) B189: .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.77-12.92 (m, 1H), 8.86 (d, J=4.0 Hz, 1H), 8.10 (dd, J=8.8, 6.0 Hz, 1H), 7.98 (m, J=11.2 Hz, 1H), 7.63 (m, 3H), 3.45 (m, 2H), 2.17 (m, 1H), 2.03 (m, 1H), 1.82 (m, 4H), 1.62 (m, 2H), 1.34 (d, J=6.8 Hz, 3H), 1.14 (m, 1H).

(502) B190: 1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.77-12.92 (m, 1H), 8.87 (m, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=11.2, 2.4 Hz, 1H), 7.62 (m, 3H), 3.45 (m, 2H), 2.16 (m, 1H), 2.03 (m, 1H), 1.84 (m, 4H), 1.64 (m, 2H), 1.34 (d, J=6.8 Hz, 3H), 1.14 (m, 1H).

Example B193: N-cyclopropyl-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(503) ##STR00354##

(504) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.42 (d, J=114 Hz, 1H), 8.86 (d, J=4.5 Hz, 1H), 8.37-8.33 (m, 1H), 8.10 (dd, J=9.2, 5.8 Hz, 1H), 8.04 (s, 0.5H), 7.98 (dd, J=11.0, 2.7 Hz, 1H), 7.90 (s, 0.5H), 7.70-7.40 (m, 4H), 3.48-3.36 (m, 2H), 2.88-2.83 (m, 1H), 2.16-2.03 (m, 2H), 1.95-1.73 (m, 4H), 1.69-1.51 (m, 2H), 1.36 (d, J=6.8 Hz, 3H), 1.17-1.14 (m, 1H), 0.69-0.68 (m, 2H), 0.59-0.57 (m, 2H).

Example B194: 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-isopropyl-1H-benzo[d]imidazole-6-carboxamide

(505) ##STR00355##

(506) 1H NMR (400 MHz, DMSO-d) δ.sub.H 12.40 (d, J=10.6 Hz, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.15-8.08 (m, 3H), 7.98 (dd, J=11.0, 2.7 Hz, 1H), 7.92 (s, 0.5 H), 7.71-7.62 (m, 2H), 7.58 (d, J=4.5 Hz, 1H), 7.55-7.43 (m, 1H), 4.14-4.09 (m, 1H), 3.42-3.42 (m, 2H), 2.20-2.00 (m, 2H), 1.95-1.70 (m, 4H), 1.69-1.50 (m, 2H), 1.36 (d, J=6.7 Hz, 3H), 1.17 (d, J=6.5 Hz, 6H).

Example B195: N-tert-butyl-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(507) ##STR00356##

(508) .sup.1H NMR (400 MHz, DMSO-d) δ 12.39 (s, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.14-7.82 (m, 3H), 7.72-7.37 (m, 5H), 3.45-3.40 (m, 2H), 2.19-1.96 (m, 2H), 1.95-1.72 (m, 4H), 1.67-1.54 (m, 2H), 1.43-1.34 (m, 12H), 1.16-1.13 (m, 1H).

Example B196: N-(tert-butyl)-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-6-carboxamide

(509) ##STR00357##

(510) 1H NMR (400 MHz, dmso) δ 12.44 (s, 1H), 8.86 (d, J=4.5 Hz, 1H), 8.09 (dd, J=9.1, 5.9 Hz, 1H), 7.98 (dd, J=11.0, 2.4 Hz, 1H), 7.85-7.35 (m, 5H), 3.56 (s, 3H), 3.43 (s, 2H), 3.27 (s, 3H), 2.20-1.96 (m, 3H), 1.94-1.71 (m, 4H), 1.68-1.56 (m, 2H), 1.36 (d, J=6.7 Hz, 3H).

Example B197: 2-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)-4,5-dihydrooxazole

(511) ##STR00358##

(512) .sup.1H NMR (400 MHz, dmso) δ 12.47 (d, J=8.5 Hz, 1H), 8.86 (d, J=4.5 Hz, 1H), 8.09 (dd, J=9.1, 5.9 Hz, 1H), 8.00-7.91 (m, 2H), 7.76-7.63 (m, 2H), 7.59-7.48 (m, 2H), 4.40 (t, J=9.2 Hz, 2H), 3.97-3.93 (m, 2H), 3.42 (s, 2H), 2.17-2.00 (m, 2H), 1.90-1.55 (m, 8H), 1.36 (d, J=6.7 Hz, 3H).

Example B198 and Example B199: methyl 5-fluoro-2-((S)-1-((1s,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-4-carboxylate and methyl 5-fluoro-2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-4-carboxylate

(513) ##STR00359##

(514) Example B198: 1H NMR (400 MHz, d-DMSO) δ 12.26 (s, 1H), 8.88 (t, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.4 Hz, 1H), 7.82 (dd, J=8.8, 4.4 Hz, 1H), 7.72-7.58 (m, 2H), 7.10 (dd, J=12.0, 8.4 Hz, 1H), 3.95 (s, 3H), 3.69-3.65 (m, 1H), 3.42 (br, 1H), 2.27-2.24 (m, 1H), 2.13-1.48 (m, 8H), 1.32 (d, J=6.8 Hz, 3H).

(515) Example B199:1H NMR (400 MHz, d-DMSO) δ 12.26 (s, 1H), 8.88 (t, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.4 Hz, 1H), 7.82 (dd, J=8.8, 4.4 Hz, 1H), 7.72-7.52 (m, 2H), 7.10 (dd, J=12.0, 8.4 Hz, 1H), 3.95 (s, 3H), 3.65 (m, 1H), 3.42 (br, 1H), 2.27-2.24 (m, 1H), 2.21-1.44 (m, 8H), 1.32 (d, J=6.8 Hz, 3H). [M+H].sup.+=450.1

Example B200 and B201: ethyl 2-((S)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-6-methyl-1H-benzo[d]imidazole-5-carboxylate and ethyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-6-methyl-1H-benzo[d]imidazole-5-carboxylate

(516) ##STR00360##

(517) Example B200: 1H NMR (DMSO-d6) δ.sub.H 12.38 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.28-7.83 (m, 3H), 7.83-7.51 (m, 2H), 7.34 (br, 1H), 4.28 (q, J=7.2 Hz, 2H), 3.51-3.38 (m, 2H), 2.60 (s, 3H), 2.18-1.49 (m, 9H), 1.36-1.23 (m, 6H).

(518) Example B201:1H NMR (DMSO-d6) δH 12.39 (s, 1H), 8.86 (d, J=4.4 Hz, 1H), 8.28-7.88 (m, 3H), 7.88-7.53 (m, 2H), 7.37 (s, 1H), 4.28 (q, J=7.2 Hz, 2H), 3.44-3.39 (m, 2H), 2.60 (s, 3H), 2.22-1.47 (m, 9H), 1.36-1.23 (m, 6H).

Example B202: 1-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)ethan-1-one

(519) ##STR00361##

(520) .sup.1H NMR (400 MHz, dmso) δ 12.58 (d, J=11.3 Hz, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.22 (s, 0.5 H), 8.10 (dd, J=9.2, 5.8 Hz, 1H), 8.04 (s, 0.5 H), 7.98 (dd, J=11.0, 2.7 Hz, 1H), 7.78 (d, J=8.4 Hz, 1H), 7.66 (td, J=9.1, 2.8 Hz, 1H), 7.63-7.47 (m, 2H), 3.45-3.43 (m, 2H), 2.61 (s, 3H), 2.21-2.01 (m, 2H), 1.94-1.73 (m, 4H), 1.69-1.52 (m, 2H), 1.37 (d, J=6.8 Hz, 3H), 1.16 (d, J=14.5 Hz, 1H).

Example B203: 4-((1s,4s)-4-(1-(7-chloro-5,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(521) ##STR00362##

(522) .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.69-13.25 (m, 1H), 8.76-9.04 (m, 1H), 8.09 (dd, J=8.8, 6.0 Hz, 1H), 7.98 (d, J=9.6 Hz, 1H), 7.53-7.73 (m, 3H), 3.41-3.50 (m, 2H), 2.12-2.23 (m, 1H), 1.99-2.07 (m, 1H), 1.73-1.95 (m, 4H), 1.48-1.69 (m, 2H), 1.34 (d, J=6.4 Hz, 3H), 1.11-1.19 (m, 1H).

Example B204 and Example B205: 4-((1R,4s)-4-((S)-1-(7-chloro-4,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline and 4-((1R,4r)-4-((R)-1-(7-chloro-4,6-difluoro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(523) ##STR00363##

(524) Example B204 .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.83-13.65 (m, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.09 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.4 Hz, 1H), 7.66 (td, J=8.8, 2.4 Hz, 1H), 7.59 (d, J=4.4 Hz, 1H), 7.37-7.50 (m, 1H), 3.37-3.50 (m, 2H), 2.15-2.26 (m, 1H), 2.00-2.06 (m, 1H), 1.84-1.94 (m, 2H), 1.72-1.82 (m, 2H), 1.62-1.70 (m, 1H), 1.53-1.60 (m, 1H), 1.36 (d, J=6.8 Hz, 3H), 1.10-1.19 (m, 1H).

(525) Example B205 .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.87-13.42 (m, 1H), 8.81-8.88 (m, J=3.6 Hz, 1H), 8.07 (dd, J=9.2, 6.0 Hz, 1H), 7.96 (dd, J=11.2, 2.4 Hz, 1H), 7.61-7.68 (m, 1H), 7.56 (d, J=4.4 Hz, 1H), 7.36-7.48 (m, 6.2 Hz, 1H), 3.37-3.48 (m, 2H), 2.14-2.22 (m, 1H), 1.97-2.04 (m, 1H), 1.83-1.92 (m, 2H), 1.71-1.80 (m, 2H), 1.60-1.68 (m, 1H), 1.52-1.57 (m, 1H), 1.34 (d, J=6.8 Hz, 3H), 1.09-1.16 (m, 1H).

Example 206: N-cyclobutyl-2-(1-(4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-4-methyl-1H-benzo[d]imidazole-6-carboxamide

(526) ##STR00364##

Example B207: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-methyl-1H-imidazo[4,5-c]pyridine-6-carboxamide

(527) ##STR00365##

(528) .sup.1H NMR (400 MHz, dmso) δ 12.67 (s, 1H), 8.89 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=11.2, 2.8 Hz, 1H), 7.88 (d, J=8.0 Hz, 1H), 7.70-7.50 (m, 3H), 3.99 (s, 3H), 3.76 (dd, J=11.2, 6.8 Hz, 1H), 3.42 (s, 1H), 2.33 (s, 1H), 2.06 (d, J=12.0 Hz, 1H), 2.02-1.83 (m, 2H), 1.78 (s, 2H), 1.67 (d, J=13.2 Hz, 1H), 1.54 (d, J=9.4 Hz, 1H), 1.36 (d, J=6.8 Hz, 3H), 1.27-1.13 (m, 1H). [M+1]500.

Example B209 and B210: methyl 2-((S)-1-((1s,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-4-carboxylate and methyl 2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazole-4-carboxylate

(529) ##STR00366##

(530) Example B209: .sup.1H NMR (DMSO-d6) δ.sub.H 12.22 (s, 1H), 8.89 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.8 Hz, 1H), 7.85 (d, J=7.6 Hz, 1H), 7.76 (d, J=7.6 Hz, 1H), 7.72-7.59 (m, 2H), 7.25 (t, J=8.0 Hz, 1H), 3.95 (s, 3H), 3.71-3.67 (m, 1H), 3.40 (br, 1H), 2.31 (br, 1H), 2.13-1.47 (m, 8H), 1.34 (d, J=6.8 Hz, 3H).

(531) Example B210: .sup.1H NMR (DMSO-d6) δ.sub.H 12.22 (s, 1H), 8.89 (d, J=4.4 Hz, 1H), 8.10 (dd, J=9.2, 6.0 Hz, 1H), 7.98 (dd, J=10.8, 2.8 Hz, 1H), 7.85 (d, J=7.6 Hz, 1H), 7.76 (d, J=7.6 Hz, 1H), 7.73-7.58 (m, 2H), 7.25 (t, J=8.0 Hz, 1H), 3.95 (s, 3H), 3.71-3.67 (m, 1H), 3.40 (br, 1H), 2.31 (br, 1H), 2.13-1.47 (m, 8H), 1.34 (d, J=6.8 Hz, 3H).

Example B211 and Example B212: 2-((S)-1-((1s,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-3H-naphtho[1,2-d]imidazole and 2-((R)-1-((1r,4R)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-3H-naphtho[1,2-d]imidazole

(532) ##STR00367##

(533) Example B211: .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.52-12.88 (m, 1H), 8.87 (d, J=4.4 Hz, 1H), 8.35 (s, 1H), 8.10 (dd, J=9.0, 6.0 Hz, 1H), 7.98 (m, 2H), 7.64 (m, 4H), 7.56 (t, J=7.2 Hz, 1H), 7.43 (m, J=7.2 Hz, 1H), 3.48 (m, 2H), 2.23 (m, 1H), 2.09 (m, 1H), 1.89 (m, 3H), 1.79 (m, 1H), 1.63 (m, 2H), 1.42 (d, J=6.8 Hz, 3H), 1.20 (m, 1H).

(534) Example B212: .sup.1H NMR (400 MHz, DMSO-d6) δ.sub.H 12.54-12.90 (m, 1H), 8.87 (d, J=4.0 Hz, 1H), 8.35 (s, 1H), 8.10 (dd, J=8.8, 6.0 Hz, 1H), 7.97 (m, 2H), 7.62 (m, 5H), 7.43 (t, J=7.6 Hz, 1H), 3.49 (m, 2H), 2.23 (m, 1H), 2.09 (m, 1H), 1.89 (m, 3H), 1.78 (m, 1H), 1.61 (m, 2H), 1.42 (d, J=6.4 Hz, 3H), 1.21 (m, 1H).

Example B215: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-(oxetan-3-yl)-1H-benzo[d]imidazole-6-carboxamide

(535) ##STR00368##

(536) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.47 (d, J=13.0 Hz, 1H), 9.01 (dd, J=19.5, 6.3 Hz, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.16-7.95 (m, 3H), 7.68 (m, 2H), 7.53 (m, 2H), 5.03 (m, 1H), 4.77 (t, J=6.7 Hz, 2H), 4.62 (td, J=6.4, 2.5 Hz, 2H), 3.43 (m, 2H), 2.19-1.53 (m, 8H), 1.37 (d, J=6.8 Hz, 3H), 1.17 (m, 1H).

Example B215: 2-(1-((1r,4r)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-(2-methoxyethyl)-1H-benzo[d]imidazole-5-carboxamide

(537) ##STR00369##

(538) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.39 (d, J=13.0 Hz, 1H), 8.79 (d, J=4.6 Hz, 1H), 8.43 (m, 1H), 8.02 (m, 3H), 7.72-7.38 (m, 4H), 3.52-3.40 (m, 4H), 3.28 (s, 3H), 2.94 (m, 11), 1.98-1.41 (m, 8H), 1.40 (d, J=7.2 Hz, 3H).

Example B216: 2-(1-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-N-(2-methoxyethyl)-1H-benzo[d]imidazole-5-carboxamide

(539) ##STR00370##

(540) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.43 (d, J=13.3 Hz, 1H), 8.86 (d, J=4.5 Hz, 1H), 8.42 (m, 1H), 8.14-7.91 (m, 3H), 7.71-7.42 (m, 4H), 3.49-3.37 (m, 6H), 3.27 (s, 3H), 2.10 (m, 2H), 1.95-1.53 (m, 6H), 1.36 (d, J=6.8 Hz, 3H), 1.16 (m, 1H).

Example B217: 5-(2-(1-((1s,4s)-4-(6-fluoroquinolin-4-ylcyclohexyl)ethyl)-1H-benzo[d]imidazol-5-yl)-3-methyl-1,2,4-oxadiazole

(541) ##STR00371##

(542) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.72 (s, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.20 (m, 1H), 8.10 (dd, J=9.2, 5.9 Hz, 1H), 7.98 (dd, J=11.0, 2.7 Hz, 1H), 7.88 (d, J=8.0 Hz, 1H), 7.67 (m, 2H), 7.60 (d, J=4.6 Hz, 1H), 3.52-3.38 (m, 2H), 2.12 (m, 2H), 1.95-1.55 (m, 6H), 1.38 (d, J=6.8 Hz, 3H), 1.19 (m, 1H).

Example B220: 5-(2-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)-1H-benzo[d]imidazol-6-yl)-3-methyl-1,2,4-oxadiazole

(543) ##STR00372##

(544) .sup.1H NMR (400 MHz, DMSO-d) δ.sub.H 12.74 (s, 1H), 8.87 (d, J=4.5 Hz, 1H), 8.20 (s, 1H), 8.10 (dd, J=9.2, 5.9 Hz, 1H), 7.98 (dd, J=11.0, 2.6 Hz, 1H), 7.88 (d, J=8.1 Hz, 1H), 7.74-7.63 (m, 2H), 7.60 (d, J=4.6 Hz, 1H), 3.53-3.39 (m, 2H), 2.41 (s, 3H), 2.18 (d, J=10.9 Hz, 1H), 2.06 (d, J=12.6 Hz, 1H), 1.95-1.54 (m, 6H), 1.38 (d, J=6.8 Hz, 3H), 1.27-1.17 (m, 1H).

Example C1a and C1b: 4-(4-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(545) ##STR00373##

Step 1: ethyl 4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-ene-1-carboxylate

(546) To a solution of trifluoromethanesulfonic anhydride (67.8 g, 0.2365 mol) in DCM (400 mL) was added pyridine (14.9 g, 0.1892 mol in 100 ml DCM) dropwise with stirring in 10 mins. The mixture was stirred for 10 mins at r.t. Ethyl 4-oxocyclohexane-1-carboxylate (26.8 g, 0.1576 mol in 100 ml DCM) was added dropwise in 15 mins. Then the mixture was stirred overnight at r.t. The reaction mixture was washed with H.sub.2O (500 mL×2), and saturated Na.sub.2CO.sub.3 solution (400 ml×2), brine (500 mL×1), the organic layer was combined and dried over Na.sub.2SO.sub.4, filtered and concentrated to give the crude product (42.7 g) as a black oil, which was used for the next step without further purification. [M+1].sup.+ 303

Step 2: ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-ene-1-carboxylate

(547) A mixture of ethyl 4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-ene-1-carboxylate (42.7 g (crude), 0.148 mol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (41.4 g, 0.163 mol), CH.sub.3COOK (58.6 g, 0.296 mol), Pd(dppf)Cl.sub.2(10.8 g, 0.0148 mol) in 1,4-dioxane (400 ml) was stirred overnight at 95° C. under N.sub.2. After determined the reaction to be complete by LCMS, the reaction was cooled to r.t. The solvent was removed under vacuo. The mixture was diluted with 500 ml solution (PE:EA=5:1), the solid was filtered and the filtrate was concentrated in vacuo. The residue was purified by a short silica gel column from PE:EA=10:1 to PE:EA=8:1 to afford desired product 56.8 g (crude) as dark oil. [M+1].sup.+ 281

Step 3: ethyl 4-(6-fluoroquinolin-4-yl)cyclohex-3-ene-1-carboxylate

(548) A mixture of ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-ene-1-carboxylate (11.96 g, 0.0427 mol), 4-bromo-6-fluoroquinoline (11.48 g, 0.0512 mol), Cs.sub.2CO.sub.3(27.82 g, 0.0854 mol), and Pd(dppf)Cl.sub.2(3.14 g, 0.0043 mol) in 1,4-dioxane was stirred overnight at 95° C. under N.sub.2. After determined the reaction to be complete by LCMS, the reaction was cooled to r.t. The solvent was removed under vacuo. The mixture was diluted with EA (200 ml), the solid was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel column from PE:EA=10:1 to PE:EA=5:1 to afford desired product 4.8 g as yellow oil. [M+1].sup.+ 300

Step 4: ethyl 4-(6-fluoroquinolin-4-yl)cyclohexane-1-carboxylate

(549) To a solution of ethyl 4-(6-fluoroquinolin-4-yl)cyclohex-3-ene-1-carboxylate (4.8 g, 0.016 mol) in THF (80 mL) was added Pd/C (480 mg, 10%). The mixture was stirred overnight under 4 atm of H.sub.2 at r.t. After determined the reaction to be complete by LCMS, the solid was filtered and the filtrate was concentrated to give the crude product (3.0 g) as a yellow oil, which was used for the next step without further purification. [M+1].sup.+ 302

Step 5: 4-(6-fluoroquinolin-4-yl)cyclohexane-1-carboxylic acid

(550) To a solution of ethyl 4-(6-fluoroquinolin-4-yl)cyclohexane-1-carboxylate (3 g, 0.0099 mol) in MeOH (30 mL) was added NaOH solution (10%, 6 ml). The mixture was stirred overnight at r.t. After determined the reaction to be complete by LCMS, MeOH was removed under vacuo. The residue was added to H.sub.2O (10 ml), extracted with EA (10 mL×2), and aqueous layer was combined. Adjusted the pH value of aqueous layer to 5˜6 with HCl (12M), extracted with EA (20 mL×2). The organic layer was combined and washed with brine (20 mL×1), dried over Na.sub.2SO.sub.4, filtered and concentrated to afford desired product 2.1 g as yellow solid. [M+1].sup.+ 274

Step 6: N-(2-amino-4-chloro-5-fluorophenyl)-4-(6-fluoroquinolin-4-yl)cyclohexane-1-carboxamide

(551) A mixture of 4-(6-fluoroquinolin-4-yl)cyclohexane-1-carboxylic acid (540 mg, 1.978 mmol) and HATU (751 mg, 1.987 mmol) in DCM (10 mL) was stirred for 5 mins under N.sub.2 at r.t. Then 4-chloro-5-fluorobenzene-1,2-diamine (316 mg, 1.978 mmol) and TEA (399 mg, 3.956 mmol) were added. The mixture was stirred overnight at r.t. After determined the reaction to be complete by LCMS, the reaction mixture was concentrated in vacuo to remove the solvent, and the residue was purified by silica gel column PE:EA=1:1 to afford desired product 400 mg as yellow oil. [M+1]416

Step 7: 4-(4-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(552) ##STR00374##

(553) A solution of N-(2-amino-4-chloro-5-fluorophenyl)-4-(6-fluoroquinolin-4-yl)cyclohexane-1-carboxamide (355 mg, 0.855 mmol) in CH.sub.3COOH (10 mL) was stirred for 3 h at 80° C. After determined the reaction to be complete by LCMS, the reaction mixture was concentrated in vacuo to remove the solvent, and the residue was purified by prep-TLC, PE:EA=1:2 to afford desired product C1a: (slow isomer in pre-TLC, 34.51 mg) .sup.1H NMR (DMSO-d.sub.6) δ 12.54 (s, 1H), 8.85 (d, J=4.0 Hz, 1H), 8.15-8.00 (m, 2H), 7.69 (t, J=8.0 Hz, 2H), 7.53 (d, J=4.0 Hz, 2H), 3.45 (t, J=12.0 Hz, 1H), 3.01 (t, J=12.0 Hz, 1H), 2.24 (d, J=12.0 Hz, 2H), 2.09-1.91 (m, 4H), 1.77 (dd, J=24.0, 12.0 Hz, 2H), [M+1].sup.+ 398; and C1b: (faster isomer in pre-TLC, 76.28 mg): .sup.1H NMR (DMSO-d.sub.6) δ 12.51 (d, J=16.0 Hz, 1H), 8.73 (d, J=4.0 Hz, 1H), 8.15-7.96 (m, 2H), 7.89-7.41 (m, 3H), 7.26 (d, J=4.0 Hz, 1H), 3.54-3.28 (m, 2H), 3.32-3.24 (m, 1H), 2.46 (s, 1H), 2.12 (d, J=8.0 Hz, 2H), 1.81 (s, 4H), [M+1]398.

(554) Compounds C2a to C20 were prepared in a procedure similar to Example C1a.

Example C2a: 4-((1r,4r)-4-(5-chloro-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(555) ##STR00375##

(556) 1H NMR (DMSO-d.sub.6) δ 12.40 (d, J=12.0 Hz, 1H), 8.85 (d, J=4.0 Hz, 1H), 8.19-7.95 (m, 2H), 7.78-7.37 (m, 4H), 7.16 (s, 1H), 3.45 (t, J=12.0 Hz, 1H), 3.00 (t, J=6.0 Hz, 1H), 2.25 (d, J=12.0 Hz, 2H), 2.10-1.90 (m, 4H), 1.77 (m, 2H), [M+1].sup.+ 380

Example C2b: 4-((1s,4s)-4-(5-chloro-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(557) ##STR00376##

(558) .sup.1H NMR (DMSO-d.sub.6) δ 12.39 (d, J=12.0 Hz, 1H), 8.72 (d, J=4.0 Hz, 1H), 8.07 (dd, J=12.0, 8.0 Hz, 2H), 7.69-7.42 (m, 3H), 7.29-7.12 (m, 2H), 3.53-3.30 (m, 4H), 2.12 (d, J=8.0 Hz, 2H), 1.81 (s, 4H), [M+1].sup.+ 380

Example C3: 6-fluoro-4-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)cyclohexyl)quinoline

(559) ##STR00377##

(560) .sup.1H NMR (DMSO-d.sub.6) δ 12.06 (s, 1H), 8.72 (d, J=4.0 Hz, 1H), 8.17-7.96 (m, 2H), 7.74-7.57 (m, 1H), 7.29 (m, 3H), 6.95 (d, J=8.0 Hz, 1H), 3.46 (s, 1H), 3.35 (s, 1H), 2.48-2.44 (m, 1H), 2.40 (s, 3H), 2.20-1.70 (m, 7H), [M+1].sup.+ 360

Example C4: 4-(4-(5-bromo-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(561) ##STR00378##

(562) .sup.1H NMR (DMSO-d.sub.6) δ 12.40 (d, J=16.0 Hz, 1H), 8.72 (d, J=4.0 Hz, 1H), 8.12-8.02 (m, 2H), 7.89-7.68 (m, 3H), 7.51-7.69 (m, 1H), 7.18-7.33 (m, 2H), 3.53-3.35 (m, 3H), 2.48-2.43 (m, 1H), 2.12 (d, J=8.0 Hz, 2H), 1.81 (s, 4H), [M+1].sup.+ 424.

Example C5a: 6-fluoro-4-((1r,4r)-4-(5-fluoro-1H-benzo[d]imidazol-2-yl)cyclohexyl)quinoline

(563) ##STR00379##

Example C5b: 6-fluoro-4-((1s,4s)-4-(5-fluoro-1H-benzo[d]imidazol-2-yl)cyclohexyl)quinoline

(564) ##STR00380##

Example C6a: 4-((1r,4r)-4-(5-cyclopropyl-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(565) ##STR00381##

Example C6b: 4-((1s,4s)-4-(5-cyclopropyl-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(566) ##STR00382##

(567) .sup.1H NMR (DMSO-d.sub.6) δ 12.05 (s, 1H), 8.72 (d, J=4.0 Hz, 1H), 8.10-8.00 (m, 2H), 7.71-7.58 (m, 1H), 7.38 (s, 1H), 7.29-7.05 (m, 2H), 6.89 (d, J=8.0 Hz, 1H), 3.44 (d, J=12.0 Hz, 1H), 2.47 (s, 1H), 2.19-1.94 (m, 4H), 1.72-1.93 (m, 5H), 0.93 (d, J=8.0 Hz, 2H), 0.66 (d, J=4.0 Hz, 2H), [M+1].sup.+ 386.

Example C7a: 4-((1r,4r)-4-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(568) ##STR00383##

(569) .sup.1H NMR (DMSO-d.sub.6) δ 12.45 (s, 1H), 8.85 (d, J=4.0 Hz, 1H), 8.19-7.99 (m, 2H), 7.75-7.41 (m, 4H), 3.44 (t, J=12.0 Hz, 2H), 3.00 (t, J=12.0 Hz, 2H), 2.24 (d, J=12.0 Hz, 3H), 2.07-1.86 (m, 4H), 1.76 (dd, J=24.0, 12.0 Hz, 2H), [M+1].sup.+ 382.

Example C7b: 4-((1s,4s)-4-(5,6-difluoro-H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(570) ##STR00384##

(571) .sup.1H NMR (DMSO-d.sub.6) δ 12.46 (s, 1H), 8.73 (d, J=4.0 Hz, 1H), 8.17-7.96 (m, 3H), 7.75-7.43 (m, 3H), 7.26 (d, J=4.0 Hz, 1H), 3.56-3.41 (m, 2H), 3.37 (s, 1H), 2.46 (s, 2H), 2.12 (d, J=8.0 Hz, 2H), 1.81 (s, 4H), [M+1].sup.+ 382.

Example C8a: methyl 2-((1r,4r)-4-(6-fluoroquinolin-4-yl)cyclohexyl)-1H-benzo[d]imidazole-5-carboxylate

(572) ##STR00385##

(573) 1H NMR (DMSO-d.sub.6) δ 12.63 (s, 1H), 8.85 (d, J=4.0 Hz, 1H), 8.20-8.00 (m, 3H), 7.85-7.62 (m, 3H), 7.56-7.52 (m, 1H), 3.87 (s, 3H), 3.47 (t, J=12.0 Hz, 1H), 3.05 (s, 1H), 2.27 (d, J=12.0 Hz, 2H), 2.10-1.94 (m, 4H), 1.79 (t, J=12.0 Hz, 2H), [M+1].sup.+ 404.

Example C8b: methyl 2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)-1H-benzo[d]imidazole-5-carboxylate

(574) ##STR00386##

(575) .sup.1H NMR (DMSO-d.sub.6) δ 12.57 (s, 1H), 8.72 (d, J=8.0 Hz, 1H), 8.28-7.98 (m, 3H), 7.81 (dd, J=16.0, 8.0 Hz, 1H), 7.71-7.49 (m, 2H), 7.27 (s, 1H), 3.87 (s, 3H), 3.44 (s, 2H), 3.30 (s, 2H), 2.14 (s, 2H), 1.83 (s, 4H), [M+1].sup.+ 404.

Example C9a: 2-((1r,4r)-4-(6-fluoroquinolin-4-yl)cyclohexyl)-1H-benzo[d]imidazole-5-carboxamide

(576) ##STR00387##

(577) 1H NMR (DMSO-d.sub.6) δ 12.44 (d, J=16.0 Hz, 1H), 8.84 (s, 1H), 8.03 (dd, J=30.2, 18.9 Hz, 4H), 7.67 (s, 2H), 7.61-7.14 (m, 3H), 3.45 (s, 1H), 3.01 (s, 1H), 2.25 (d, J=12.0 Hz, 2H), 2.10-1.93 (m, 4H), 1.76 (d, J=12.0 Hz, 2H), [M+1].sup.+ 389.

Example C9b: 2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)-1H-benzo[d]imidazole-5-carboxamide

(578) ##STR00388##

(579) .sup.1H NMR (DMSO-d.sub.6) δ 12.41 (d, J=16.0 Hz, 1H), 8.71 (s, 1H), 8.23-7.70 (m, 4H), 7.81-7.36 (m, 3H), 7.24 (s, 2H), 3.50-3.36 (m, 3H), 3.28 (s, 1H), 2.12 (s, 2H), 1.90-1.75 (m, 4H), [M+1].sup.+ 389.

Example C10: 4-(4-(2-(5-cyclopropyl-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(580) ##STR00389##

Example C1: 4-((1r,4r)-4-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)ethyl)cyclohexyl)-6-fluoroquinoline

(581) ##STR00390##

Example C12a: 4-((1R,4s)-4-((S)-2-(5-chloro-1H-benzo[d]imidazol-2-yl)propyl)cyclohexyl)-6-fluoroquinoline

(582) ##STR00391##

Example C12b: 4-((1S,4s)-4-((R)-2-(5-chloro-1H-benzo[d]imidazol-2-yl)propyl)cyclohexyl)-6-fluoroquinoline

(583) ##STR00392##

Example C13: 4-((1S,4s)-4-((R)-2-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)propyl)cyclohexyl)-6-fluoroquinoline

(584) ##STR00393##

Example C14: 4-((1S,4s)-4-((R)-2-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)propyl)cyclohexyl)-6-fluoroquinoline

(585) ##STR00394##

Example C15:6-fluoro-4-((1S,4s)-4-((R)-2-(5,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)propyl)cyclohexyl)quinoline

(586) ##STR00395##

Example C16: 4-((1S,4s)-4-((R)-2-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)propyl)cyclohexyl)-6-fluoroquinoline

(587) ##STR00396##

Example C17:6-fluoro-4-((1S,4s)-4-((R)-2-(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)propyl)cyclohexyl)quinoline

(588) ##STR00397##

Example C18: (R)-6-fluoro-4-(4-(2-(5,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)propyl)piperazin-1-yl)quinoline

(589) ##STR00398##

Example C19: (R)-4-(4-(2-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)propyl)piperazin-1-yl)-6-fluoroquinoline

(590) ##STR00399##

Example C20: (R)-6-fluoro-4-(4-(2-(4,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)propyl)piperazin-1-yl)quinoline

(591) ##STR00400##

Example D1: 6-chloro-2-(5-phenylbicyclo[2.2.1]heptan-2-yl)-1H-benzo[d]imidazole

(592) ##STR00401##

Step 1: bicyclo[2.2.1]hept-5-ene-2-carbaldehyde

(593) At −78° C., to a mixture of ZnBr.sub.2 (25 g, 111 mmol) in DCM (450 mL) was added cyclopenta-1,3-diene (30 mL, 363 mmol) dropwise, the reaction mixture was stirred for 30 min at −78° C., then acrylaldehyde (15 mL, 225 mmol) was added, the reaction mixture was stirred for 1 hour at −78° C., then the reaction mixture was poured into DCM (500 mL), washed with brine (200 ml×3), the DCM layer was concentrated and purified by sili-gel to give 20 g of the title compound as a yellow oil.

Step 2: 5-phenylbicyclo[2.2.1]heptane-2-carbaldehyde

(594) Under N.sub.2, a mixture of bicyclo[2.2.1]hept-5-ene-2-carbaldehyde (1.2 g, 10 mmol), iodobenzene (2.1 g, 10 mmol), Et.sub.3N (4.0 mL, 29 mmol), formic acid (0.8 ml, 21 mmol) and Pd(PPh.sub.3).sub.2Cl.sub.2 (0.4 g, 0.57 mmol) in DMF (4.0 mL) was heated to 60° C. for 4 hours. After cooled down, EA was added, washed with water and brine, dried over Na.sub.2SO.sub.4, concentrated, purified by sili-gel to give 1.0 g of the title compound as a yellow oil. MS (ESI) m/e [M+1].sup.+=201.1

Step 3: 6-chloro-2-(5-phenylbicyclo[2.2.1]heptan-2-yl)-1H-benzo[d]imidazole

(595) A solution of 5-phenylbicyclo[2.2.1]heptane-2-carbaldehyde (760 mg, 3.8 mmol), 4-chlorobenzene-1,2-diamine (450 mg, 3.16 mmol) and benzoquinone (450 mg, 4.16 mmol) in 1,4-dioxane (30 mL) was stirred overnight at 95° C. under N.sub.2. The reaction mixture was concentrated and purified by column chromatography to give 900 mg of the crude product, which was recrystallized from DCM and PE to give 100 mg of the title compound. .sup.1H NMR (DMSO-d.sub.6) δ.sub.H12.40 (s, 1H), 7.38-7.61 (m, 2H), 7.25-7.32 (m, 4H), 7.12-7.18 (m, 2H), 3.02-3.08 (m, 1H), 2.86-2.90 (m, 1H), 2.60-2.63 (m, 1H), 2.41-2.42 (m, 1H), 2.23-2.29 (m, 1H), 1.93-1.99 (m, 1H), 1.83-1.89 (m, 1H), 1.71-1.77 (m, 1H), 1.43-1.56 (m, 2H), MS (ESI) m/e [M+1].sup.+=323.7.

Example D2:5-chloro-2-(2-(5-phenylbicyclo[2.2.1]heptan-2-yl)ethyl)-1H-benzo[d]imidazole

(596) ##STR00402##

Step 1: methyl 3-(5-phenylbicyclo[2.2.1]heptan-2-yl)acrylate

(597) A mixture of 5-phenylbicyclo[2.2.1]heptane-2-carbaldehyde (2.0 g, 10 mmol) and methyl (triphenylphosphoranylidene)acetate (3.3 g, 10 mmol) in toluene (50 mL) was heated to 110° C. for 3 hours, after cooled down, the reaction mixture was concentrated, purified by column chromatography to give 1.8 g of the title compound. MS (ESI) m/e [M+1].sup.+=257.1.

Step 2: 3-(5-phenylbicyclo[2.2.1]heptan-2-yl)acrylic acid

(598) A mixture of methyl 3-(5-phenylbicyclo[2.2.1]heptan-2-yl)acrylate (1.8 g, 7.0 mmol) and LiOH.H.sub.2O (600 mg, 14 mmol) in THF/MeOH/H2O (10 mL/10 mL/10 mL) was stirred for overnight at room temperature, the reaction mixture was concentrated, water was added, the pH value was adjusted to 5 with 1N HCl aq, extracted with EA, the EA layer was washed with brine, dried over Na.sub.2SO.sub.4, concentrated to give 1.6 g of the crude title compound. MS (ESI) m/e [M+1].sup.+=243.1.

Step 3: N-(2-amino-4-chlorophenyl)-3-(5-phenylbicyclo[2.2.1]heptan-2-yl)acrylamide

(599) To a solution of 3-(5-phenylbicyclo[2.2.1]heptan-2-yl)acrylic acid (400 mg, 1.65 mmol) in DMF (10 mL) were added DIPEA (0.7 mL, 4.0 mmol), HATU (950 mg, 2.5 mmol) and 4-chlorobenzene-1,2-diamine (300 mg, 2.1 mmol), the reaction mixture was stirred for overnight at room temperature, EA was added, washed with brine, dried over Na.sub.2SO.sub.4, concentrated and purified by sili-gel to give 240 mg of the title compound. MS (ESI) m/e [M+1].sup.+=367.1.

Step 4: 5-chloro-2-(2-(5-phenylbicyclo[2.2.1]heptan-2-yl)ethyl)-1H-benzo[d]imidazole

(600) ##STR00403##

(601) Under H.sub.2(1 atm), a mixture of N-(2-amino-4-chlorophenyl)-3-(5-phenylbicyclo[2.2.1]heptan-2-yl)acrylamide (240 mg, 0.65 mmol) and Pt/C (50 mg) in MeOH (25 mL) was stirred for 1.5 hours, the mixture was filtered, concentrated. HOAc (7 mL) was added, the reaction mixture was heated to 100° C. for 2 hours, after cooled down, the reaction mixture was poured into water, the pH value was adjusted to 8 with sat.NaHCO.sub.3aq, extracted with EA, the EA layer was washed with brine, dried over Na.sub.2SO.sub.4, concentrated and purified by sili-gel to give 100 mg of the title compound. .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ.sub.H 12.37 (s, 1H), 7.39-7.59 (m, 2H), 7.08-7.33 (m, 6H), 2.76-2.88 (m, 2H), 2.62-2.72 (m, 1H), 2.25-2.32 (m, 1H), 2.05-2.13 (m, 1H), 1.47-1.84 (m, 7H), 1.20-1.34 (m, 2H), 1.07-1.16 (m, 1H), 0.80-0.88 (m, 1H), MS (ESI) m/e [M+1].sup.+=351.7

(602) Compounds D3 to D34 were prepared in a procedure similar to Example D2.

Example D3: 4-(5-(2-(5-chloro-H-benzo[d]imidazol-2-yl)ethyl)bicyclo[2.2.1]heptan-2-yl)quinoline

(603) ##STR00404##

Example D4: 4-(5-(2-(5-chloro-H-benzo[d]imidazol-2-ylethyl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(604) ##STR00405##

Example D5: 4-(5-((R)-2-(5-chloro-1H-benzo[d]imidazol-2-yl)propyl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(605) ##STR00406##

Example D6:6-fluoro-4-(5-((R)-2-(5-fluoro-1H-benzo[d]imidazol-2-yl)propyl)bicyclo[2.2.1]heptan-2-yl)quinoline

(606) ##STR00407##

Example D7: methyl 2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-1H-benzo[d]imidazole-5-carboxylate

(607) ##STR00408##

Example D8: 4-(5-((R)-2-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)propyl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(608) ##STR00409##

Example D9: 4-(5-((R)-2-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)propyl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(609) ##STR00410##

Example D10: 6-fluoro-4-(5-((R)-2-(5,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)propyl)bicyclo[2.2.1]heptan-2-yl)quinoline

(610) ##STR00411##

Example D11: 6-fluoro-4-(5-((R)-2-(4,5,7-trifluoro-H-benzo[d]imidazol-2-yl)propyl)bicyclo[2.2.1]heptan-2-yl)quinoline

(611) ##STR00412##

Example D12: 4-(5-((R)-2-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)propyl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(612) ##STR00413##

Example D13:2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-1H-benzo[d]imidazole-5-carboxamide

(613) ##STR00414##

Example D14: 2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-N-methyl-1H-benzo[d]imidazole-5-carboxamide

(614) ##STR00415##

Example D15: 2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide

(615) ##STR00416##

Example D16: aziridin-1-yl(2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-1H-benzo[d]imidazol-5-yl)methanone

(616) ##STR00417##

Example D17: azetidin-1-yl(2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-1H-benzo[d]imidazol-5-yl)methanone

(617) ##STR00418##

Example D18: N-cyclobutyl-2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-1H-benzo[d]imidazole-5-carboxamide

(618) ##STR00419##

Example D19: 2-((2R)-1-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propan-2-yl)-N-(3-hydroxycyclobutyl)-1H-benzo[d]imidazole-5-carboxamide

(619) ##STR00420##

Example D20: 4-(5-((R)-1-(5-chloro-1H-benzo[d]imidazol-2-yl)propan-2-yl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(620) ##STR00421##

Example D21:6-fluoro-4-(5-((R)-1-(5-fluoro-1H-benzo[d]imidazol-2-yl)propan-2-yl)bicyclo[2.2.1]heptan-2-yl)quinoline

(621) ##STR00422##

Example D22: methyl 2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate

(622) ##STR00423##

Example D23: 4-(5-((R)-1-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)propan-2-yl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(623) ##STR00424##

Example D24: 4-(5-((R)-1-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)propan-2-yl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(624) ##STR00425##

Example D25:6-fluoro-4-(5-((R)-1-(5,6,7-trifluoro-1H-benzo[d]imidazol-2-yl)propan-2-yl)bicyclo[2.2.1]heptan-2-yl)quinoline

(625) ##STR00426##

Example D26: 6-fluoro-4-(5-((R)-1-(4,5,7-trifluoro-1H-benzo[d]imidazol-2-yl)propan-2-yl)bicyclo[2.2.1]heptan-2-yl)quinoline

(626) ##STR00427##

Example D27: 4-(5-((R)-1-(5,6-difluoro-7-methyl-1H-benzo[d]imidazol-2-yl)propan-2-yl)bicyclo[2.2.1]heptan-2-yl)-6-fluoroquinoline

(627) ##STR00428##

Example D28: 2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propyl)-1H-benzo[d]imidazole-5-carboxamide

(628) ##STR00429##

Example D29: 2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propyl)-N-methyl-1H-benzo[d]imidazole-5-carboxamide

(629) ##STR00430##

Example D30: 2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propyl)-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide

(630) ##STR00431##

Example D31: aziridin-1-yl(2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propyl)-1H-benzo[d]imidazol-5-yl)methanone

(631) ##STR00432##

Example D32: azetidin-1-yl(2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propyl)-1H-benzo[d]imidazol-5-yl)methanone

(632) ##STR00433##

Example D33: N-cyclobutyl-2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-yl)propyl)-1H-benzo[d]imidazole-5-carboxamide

(633) ##STR00434##

Example D34: 2-((2R)-2-(5-(6-fluoroquinolin-4-yl)bicyclo[2.2.1]heptan-2-yl)propyl)-N-(3-hydroxycyclobutyl)-1H-benzo[d]imidazole-5-carboxamide

(634) ##STR00435##

(635) Examples E1 to E8 were prepared in a similar procedure.

Example E1: 4-(3-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(636) ##STR00436##

Example E2: 4-(3-(5,6-difluoro-H-benzo[d]imidazol-2-yl)cyclohexyl)-6-fluoroquinoline

(637) ##STR00437##

Example E3: methyl 2-(3-(6-fluoroquinolin-4-yl)cyclohexyl)-1H-benzo[d]imidazole-6-carboxylate

(638) ##STR00438##

Example E4: 2-(3-(6-fluoroquinolin-4-yl)cyclohexyl)-N-methyl-1H-benzo[d]imidazole-6-carboxamide

(639) ##STR00439##

Example E5: 2-(3-(6-fluoroquinolin-4-yl)cyclohexyl)-N,N-dimethyl-1H-benzo[d]imidazole-6-carboxamide

(640) ##STR00440##

Example E6: N-cyclopropyl-2-(3-(6-fluoroquinolin-4-yl)cyclohexyl)-1H-benzo[d]imidazole-6-carboxamide

(641) ##STR00441##

Example E7: N-cyclobutyl-2-(3-(6-fluoroquinolin-4-yl)cyclohexyl)-1H-benzo[d]imidazole-6-carboxamide

(642) ##STR00442##

Example E8: 2-(3-(6-fluoroquinolin-4-yl)cyclohexyl)-N-(3-hydroxycyclobutyl)-1H-benzo[d]imidazole-6-carboxamide

(643) ##STR00443##

Example F: Biological Assays

(644) IDO1 Enzymatic Assay

(645) Recombinant IDO1 was overexpressed and purified from E. coli cells with an N-terminal His tag. IDO1 enzymatic assay was carried out using a methodology similar to described in the literature (J. Biol. Chem. (1980), 255, 1339-1345). The reaction mixture contains 50 nM IDO1, 1.3 mM D-tryptophan, 5 mM L-ascorbic acid, 6.25 M methylene Blue, 0.4 mg/mL catalase and compound (or DMSO) in a buffer containing 50 mM potassium phosphate pH 7.5 and 0.1% BSA. After incubation at 24° C. for 1.5 hours, absorbance of the reaction mixture was continuously read at 321 nm to monitor the formation of N′-formylkynurenine by a FULOstar OMEGA plate reader (BMG LABTECH) for 1 hour. The enzymatic activity was determined by measuring the slope of the linear absorbance increase as a function of time. The IC.sub.50s are calculated based on remaining enzyme activity in the presence of increasing concentrations of compounds.

(646) As shown in Table 1 below, the representative compounds disclosed herein substantially show no enzymatic activity as their IC50s are larger than 10000.

(647) 293-TDO2 Cell-Based TDO2 Kyn (Kynurenine) Production Assay:

(648) The inhibitory activity of TDO2 inhibitors is determined by using a colorimetric reaction to measure Kyn generated from L-Trp (L-Tryptophon) oxidation by cellular TDO2 in HEK293-TDO2 cells stably transfected with a plasmid expression of Tryptophan 2,3-dioxygenase (for short, 293-TDO2).

(649) HEK293 cells were obtained from the American Type Culture Collection and 293-TDO2 were recovered in 10% FBS-containing phenol red-free DMEM medium. Cells were plated onto a 96-well plate (100p/well) at 10000 cells per well and kept at 37° C. in a humidified incubator supplied with 5% CO.sub.2. 4 hours later, Compounds at different concentrations diluted in dimethylsulfoxide (DMSO) were added to plate. Cells were kept at 37° C. in a humidified incubator supplied with 5% CO.sub.2. After 48 hours of incubation, 100 μl supernatant from each well was removed to a new plate. The protein in the medium was precipitated with the addition of 8 μl 6N trichloroacetic acid. The plate was incubated at 60° C. for 30 minutes and then centrifugation at 2500 rpm for 10 minutes to remove sediments. 80 μl supernatants were carefully removed to a new clean plate and added with an equal volume of 2% 4-(Dimethylamino) benzaldehyde (D2004, sigma) dissolved in glacial acetic acid. The absorbance at 480 nm wavelength derived from Kyn was measured using a PHERAstar FS plate reader (BMG LABTECH). The IC.sub.50 for each compound was derived from fitting the dose-response data to the four-parameter logistic model by using XLfit software (IDBS).

(650) HeLa Cell-Based IDO1 Kyn (Kynurenine) Production Assay:

(651) The inhibitory activity of IDO1 inhibitors is determined by using a colorimetric reaction to measure Kyn generated from L-Trp (L-Tryptophon) oxidation by cellular IDO1 in HeLa cells after induction of IDO1 expression by IFN-γ.

(652) Hela cells were obtained from the American Type Culture Collection and recovered in 10% FBS-containing phenol red-free DMEM medium. Cells were plated onto a 96-well plate (100 μl/well) at 8000 cells per well and kept at 37° C. in a humidified incubator supplied with 5% CO.sub.2. 4 hours later, Human recombinant IFN-γ (8901SC, CST) was added to cells (final concentration 100 ng/mL) to stimulate endogenous IDOL. Compounds at different concentrations diluted in dimethylsulfoxide (DMSO) were added simultaneously with IFN-γ and 0.4 mM L-Trp. Cells were kept at 37° C. in a humidified incubator supplied with 5% CO.sub.2. After 48 hours of incubation, 100 μl supernatant from each well was removed to a new plate. The protein in the medium was precipitated with the addition of 8 μl 6N trichloroacetic acid. The plate was incubated at 60° C. for 30 minutes and then centrifugation at 2500 rpm for 10 minutes to remove sediments. 80 μl supernatants were carefully removed to a new clean plate and added with an equal volume of 2% 4-(Dimethylamino)benzaldehyde (D2004, sigma) dissolved in glacial acetic acid. The absorbance at 480 nm wavelength derived from Kyn was measured using a PHERAstar FS plate reader (BMG LABTECH). The IC.sub.5C for each compound was derived from fitting the dose-response data to the four-parameter logistic model by using XLfit software (IDBS).

(653) TABLE-US-00001 TABLE 1 Cellular activity data EC.sub.50s (IDO1 enzymatic assay and Hela Cell-Based IDO1) of 1H-benzo[d] imidazol Enzyme assay Cell-Based EC.sub.50 (nM) Ex. No. IC50(nM) Hela IDO1 A1a >10000 51 A1b >10000 8 A2a >10000 241 A2b >10000 53 A3a ND 72 A3b ND 6.8 A4a >10000 131 A4b >10000 13 A5a ND 184 A5b ND 23 A6a >10000 141 A6b >10000 14 A7a ND 87 A7b ND 3.6 A8a ND 528 A8b ND 50 A9a >10000 186 A9b >10000 24 A10a >10000 91 A10b >10000 10 A11a ND 135 A11b ND 14 A12 >10000 11 A13 >10000 8.4 A14 >10000 >10000 A15 ND 1953 A16 ND 251 A17 ND 5 A18 5300 50 A19 >10000 8.2 A20 >10000 89 A21 >10000 131 A22 >10 148 A23a >10000 56 A23b 3250 24 A24 ND 158 A25 ND 268 A26a ND 466 A26b ND 205 A27 ND 158 A28 ND 1806 A29 ND 179 A30a >10000 44 A30b >10000 39 A31 ND 115 A32 8100 143 A33a >10000 >10000 A33b 8200 8.2 A34a 8000 168 A34b 4800 87 A35 >10000 107 A36 ND 1670 A37a >10000 223 A37b 6900 99 A38 >10000 143 A39 ND 150 A40 >10000 852 A41 >10000 481 B1a ND 0.42 B1b ND 59 B1c ND ND B1d ND ND B2 ND 0.95 B2a ND 0.38 B2b ND 50 B3 ND 1.3 B3a ND 0.55 B3b ND 81 B4 ND 1.4 B5 ND 1.4 B6 ND 0.85 B7 ND ND B8 ND 6.9 B9 ND ND B10 ND ND B11 ND 64.1 B12 ND 46.0 B13 ND ND B14 ND 12.6 B15 ND ND B16 ND ND B17 ND 0.58 B18 ND ND B19 ND ND B20 ND ND B21 ND ND B22 ND ND B23 ND ND B24 ND ND B25a ND 5.1 B25b ND 3.1 B26 ND ND B27 ND ND B28 ND ND B29 ND ND B30 ND ND B31 ND ND B32 ND ND B33 ND ND B34 ND ND B35 ND ND B36 ND ND B37 ND ND B38 ND ND B39 ND ND B40 ND ND B41 ND ND B42 ND ND B43 ND ND B44 ND ND B45 ND ND B46 ND ND B47 ND ND B48 ND ND B49 ND ND B50 ND ND B51 ND ND B52 ND ND B53 ND ND B54 ND ND B55 ND ND B56 ND ND B57 ND ND B58 ND ND B59 ND ND B60 ND ND B61 ND ND B62 ND ND B63 ND ND B64 ND ND B65 ND ND B66 ND ND B67 ND ND B68 ND ND B69 ND ND B70 ND ND B71 ND ND B72 ND ND B73 ND ND B74 ND ND B75 ND ND B76 ND ND B77 ND ND B78 ND ND B79 ND ND B80 ND ND B81 ND ND B82 ND ND B83 ND ND B84 ND ND B85 ND ND B86 ND ND B87 ND ND B88 ND ND B89 ND ND B90 ND ND B91 ND ND B92 ND ND B93 ND ND B94 ND ND B95 ND ND B96 ND ND B97 ND ND B98 ND ND B99 ND ND B100 ND ND B101 ND ND B102 ND ND B103 ND ND B104 ND ND B105 ND ND B106 ND ND B107 ND ND B108 ND ND B109 ND ND B110 ND ND B111 ND ND B112 ND ND B113 ND ND B114 ND ND B115 ND ND B116 ND ND B117 ND ND B118 ND ND B119 ND ND B120 ND ND B121 ND ND B122 ND ND B123 ND 6.79 B124 ND 16.42 B125 ND 8.79 B126 ND ND B127 ND ND B128 ND ND B129 ND ND B130 ND ND B131 ND ND B132 ND ND B133 ND ND B134 ND ND B134 ND ND B135 ND ND B136 ND 296.2 B137 ND ND B138 ND 18.8 B139 ND ND B140 ND ND B141 ND 6.89 B142 ND ND B143 ND ND B144 ND ND B145 ND ND B146 ND ND B147 ND ND B148 ND ND B149 ND 0.96 B150 ND 10.94 B151 ND 82.3 B152 ND 62.9 B153 ND 4.7 B154 ND 50.0 B155 ND 24.3 B156 ND 3.1 B157 ND 3.8 B158 ND 6.9 B159 ND 67.7 B160 ND 46.0 B161 ND 1.6 B163 ND 567.4 B164 ND 5.8 B165 ND 470.3 B166 ND 250.7 B167 ND 18.8 B168 ND 4.86 B169 ND 19.6 B170 ND 38.8 B171 ND 40.2 B172 ND 16.4 B173 ND 12.7 B174 ND 26.9 B175 ND 1.7 B176 ND 2.9 B177 ND 6.9 B178 ND 283.4 B179 ND 36.2 B180 ND 384.1 B181 ND 2.7 B182 ND 86.7 B183 ND >1000 B184 ND >1000 B185 ND 122.3 B186 ND 193.1 B187 ND 17.1 B188 ND 787.9 B189 ND 45.9 B190 ND 5.74 B191 ND 1.14 B192 ND 8.97 B193 ND 12.6 B194 ND 50.6 B195 ND 74.5 B196 ND 26.5 B197 ND 8.1 B198 ND 983.9 B199 ND 21.9 B200 ND 73.3 B201 ND 1.6 B202 ND 2.9 B203 ND 8.8 B204 ND 6.79 B205 ND 28.9 B206 ND 27.1 B207 ND 18.4 B208 ND >1000 B210 ND 26.6 B211 ND 1.3 B212 ND 27.9 B213 ND 1.8 B214 ND 84.0 B215 ND 958.8 B216 ND 62.9 B217 ND 1.2 B218 ND 1.8 B219 ND 13.7 B220 ND 0.96 C1a ND >10000 C1b ND 24 C2a ND 74 C2b ND 11 C3 ND 16 C4 ND 9.1 C5a ND 1434 C5b ND 73 C6a ND ND C6b ND 14 C7a ND 1360 C7b ND 70 C8a ND 1205 C8b ND 37 C9a ND >10000 C9b ND 1243 C10 ND 7 C11 ND 12 C12a ND ND C12b ND ND C13 ND ND C14 ND ND C15 ND ND C16 ND ND C17 ND ND C18 ND ND C19 ND ND C20 ND ND D1 ND 1086 D2 ND 69 D3 ND ND D4 ND ND D5 ND ND D6 ND ND D7 ND ND D8 ND ND D9 ND ND D10 ND ND D11 ND ND D12 ND ND D13 ND ND D14 ND ND D15 ND ND D16 ND ND D17 ND ND D18 ND ND D19 ND ND D20 ND ND D21 ND ND D22 ND ND D23 ND ND D24 ND ND D25 ND ND D26 ND ND D27 ND ND D28 ND ND D29 ND ND D30 ND ND D31 ND ND D32 ND ND D33 ND ND D34 ND ND E1 ND ND E2 ND ND E3 ND ND E4 ND ND E5 ND ND E6 ND ND E7 ND ND E8 ND ND

(654) The representative compounds disclosed herein exhibited of inhibiting Hela Cell-Based IDO1 with EC.sub.50 values ranging less than 10000 nM.

(655) It is to be understood that, if any prior art publication is referred to herein, such reference does not constitute an admission that the publication forms apart of the common general knowledge in the art in any country.

(656) In the claims which follow and in the preceding description of the invention, except where the context requires otherwise due to express language or necessary implication, the word “comprise” or variations such as “comprises” or “comprising” is used in an inclusive sense, i.e., to specify the presence of the stated features but not to preclude the presence or addition of further features in various embodiments of the invention.

(657) The disclosures of all publications, patents, patent applications and published patent applications referred to herein by an identifying citation are hereby incorporated herein by reference in their entirety.

(658) Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it is apparent to those skilled in the art that certain minor changes and modifications will be practiced. Therefore, the description and Examples should not be construed as limiting the scope of the invention.