Coating system

Abstract

The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions.

Claims

1. A coating system comprising: (i) an aqueous solution comprising (ia) at least one gum having emulsifying properties selected from the group consisting of gum acacia, gum ghatti and tic gums, and (ib) at least one film forming compound consisting of carboxymethylcellulose and/or hydroxypropylmethylcellulose, and (ii) powder particles having a mass median diameter which is less than 1 m of at least one lipid compound which is selected from the group consisting of saturated fatty acids and salts thereof which are suspended in the aqueous solution (i).

2. The coating system according to claim 1, wherein the mass median diameter of the powder particles of the least one lipid compound is less than 0.8 m.

3. The coating system according to claim 1, further comprising at least one emulsifier selected from the group consisting of sucrose ester, ascorbyl palmitate and polyoxyethylene-sorbitan-fatty acid esters.

4. The coating system according to claim 1, which further comprises (iv) at least one plasticizer.

5. The coating system according to claim 1, wherein the at least one lipid compound is present in an amount of 10 to 50 wt. %, based on total weight of the coating system.

6. The coating system according to claim 1, wherein the at least one gum having emulsifying properties is present in an amount of 5 to 30 wt. %, based on total weight of the coating system.

7. The coating system according to claim 1, wherein the at least one film forming compound is present in an amount of 40 to 80 wt. %, based on total weight of the coating system.

8. The coating system according to claim 4, wherein the at least one plasticizer is present in an amount of 5 to 20 wt. %, based on total weight of the coating system, and wherein the plasticizer is at least one selected from the group consisting of sugars, mannitol, sorbitol, glycerol, mono- and diglyceride, acetylated monoglyceride, polyethylene glycol (PEG) and polypropylene glycol.

9. The coating system according to claim 1, further comprising at least one further ingredient in an amount of up to 5 wt. %, based on total weight of the coating system, which is selected from the group consisting of dyestuffs, antioxidants, fillers, pH buffers and taste masking substances.

10. The coating system according to claim 5, wherein the at least one lipid compound is present in an amount of 20 to 40 wt-%, based on the total weight of the coating system.

11. The coating system according to claim 6, wherein the at least one gum having emulsifying properties is present in an amount of 10 to 25 wt. %, based on the total weight of the coating system.

12. The coating system according to claim 7, wherein the at least one film forming compound is present in an amount of 45 to 70 wt. %, based on the total weight of the coating system.

13. The coating system according to claim 8, wherein the at least one plasticizer comprises sucrose.

14. A coating system comprising powder particles of stearic acid having a mass median diameter of less than 1 m which are suspended in an aqueous solution comprising (a) gum acacia, and (b) hydroxypropylmethylcellulose.

15. The coating system according to claim 14, wherein the mass median diameter of the powder particles of stearic acid is less than 0.8 m.

16. The coating system according to claim 14, wherein the coating system comprises, based on total weight of the coating system: (i) 10 to 50 wt. % of the stearic acid, (ii) 5 to 30 wt. % of the gum acacia, and (iii) 40 to 80 wt. % of the hydroxypropylmethylcellulose.

17. A composition comprising: (a) a core which comprises at least one fat soluble compound; and (b) a coating system according to claim 1 surrounding the core.

18. The composition according to claim 17, wherein the fat soluble compound is at least one selected from the group consisting of vitamin A, vitamin A acetate, vitamin A palmitate, vitamin E, vitamin E acetate, vitamin K, vitamin D3, polyunsaturated fatty acids (PUFA) and carotenoids.

19. The composition according to claim 17, comprising, based on total weight of the composition: (a) 50 to 95 wt. % of the core; and (b) 5 to 50 wt. % of the coating system.

20. A food product, feed product, dietary supplement and/or pharmaceutical product, comprising the composition according claim 17.

Description

EXAMPLE 1

Coated Particles Comprising Vitamin A

(1) Step 1: Coating Formulation

(2) 100 g Hydroxypropylmethylcellulose (HPMC) type methocel E19 are added in 1550 g deionised water (80-90 C.) and left for about 1 hour. Then 40 g of gum acacia Senegal (Benecke) is added. The solution is then left overnight at room temperature for degassing. 676 g of the previous solution is heated up at 50-60 C. 24 g of stearic acid (Merck, plant type) is added and mixed. The micronisation of the stearic acid is then ensured by a Polytron 6000 rotor stator system by 20000 rpm for 10 minutes. The quick cooling of the suspension is ensured by the addition of it in a 284 g of water/ice mixed (about 250 g ice and 34 g water). The final composition of the coating formulation is: 40 g HPMC, 24 g stearic acid, 16 g of gum acacia, 904 g of demineralised water.

(3) The size of the particles of stearic acid in the suspension are measured with a Malvern Mastersizer 2000 with Ultrasound at d3,2=0.144 m, d10=0.075 m, d50=0.17 m, d90=0.83 m.

(4) Step 2: Application of the Coating Formulation on the Core Surface

(5) 300 g of a beadlet Vitamin A form (as described in patent WO 2007/045488 and containing 38% Vitamin A acetate, 46% capsul HS, 11% sucrose, 5% silicic acid) is fluidised in a small laboratory fluid bed equipment (DMR, WFP mini) and used as Core particles. 194 g of the coating formulation obtained in the step 1 is sprayed on the surface of the beadlets with a 2-fluid nozzle (air pressure: 1.5 bars) in a bottom-spray configuration. The spraying time is of about 75 min with an inlet air temperature of 80 C. The final composition of the product obtained is:

(6) TABLE-US-00001 TABLE 1 Compound of Example 1 Ingredients Wt-% CORE (beadlets) 95 HPMC 2.5 Gum acacia 1.0 Stearic acid 1.5

EXAMPLE 2

Coated Particles Comprising Vitamin A

(7) Step 1: Coating Formulation

(8) 100 g Hydroxypropylmethylcellulose (HPMC) type methocel E19 are added in 1300 g deionised water (80-90 C.) and left for about 1 hour. Then 40 g of gum acacia Senegal (Benecke) is added. The solution is then left overnight at room temperature for degassing. 60 g of stearic acid (Merck, plant type) is added and mixed. The micronisation of the stearic acid is then ensured by a Polytron 6000 rotor stator system by 20000 rpm for 60 minutes. The quick cooling of the suspension is ensured by the addition of it in a 500 g of water/ice mixed (about 450 g ice and 50 g water). Finally, 96 g of deionised water are added. The final composition of the coating formulation is: 100 g HPMC, 60 g stearic acid, 40 g of gum acacia, 1800 g of demineralised water.

(9) The size of the particles of stearic acid in the suspension are measured with a Malvern Mastersizer 2000 at d3,2=0.163 m, d10=0.078 m, d50=0.19 m, d90=7.3 m.

(10) Step 2: Application of the Coating Formulation on the Core Surface

(11) 300 g of a beadlet Vitamin A form (as described in patent WO 2007/045488 and containing 26% Vitamin A acetate, 1% of mixed tocopherol, 55% capsul HS, 14% fructose, 4% starch) is fluidised in a small laboratory fluid bed equipment (DMR, WFP mini) and used as Core particles. 410 g of the coating formulation obtained in the step 1 is sprayed on the surface of the beadlets with a 2-fluid nozzle (air pressure: 1.5 bars) in a top-spray configuration. The spraying time is of about 157 min with an inlet air temperature of 80 C.

(12) 50 g of the obtained product is then mixed with 9 g stearic acid plant (Merck) and heated up to 75 C. for 10 minutes. The product is then cooled to RT by mixing. The final composition of the product obtained is:

(13) TABLE-US-00002 TABLE 2 Compound of Example 2 Ingredients Wt-% CORE (beadlets) 74.6 HPMC 5.1 Gum acacia 2.0 Stearic acid micronised 3.1 Stearic acid pure as additional layer 15.2

(14) Retention in typical feed premix composition at 25 C., 80% r.H. after 3 months

(15) Rovimix A 500 WS (non coated form) 30%

(16) Compound of example 2 86.3%

EXAMPLE 3

Coated Particles Comprising PUFA

(17) Step 1: Coating Formulation

(18) 156 g Hydroxypropylmethylcellulose (HPMC) type methocel E7 are added in 1044 g deionised water (80-90 C.) and left for about 1 hour. The solution is then left overnight at room temperature for degassing. In 1031 g of the previous solution 36 g of stearic acid (Merck, plant type) is added and mixed. The micronisation of the stearic acid is then ensured by a Polytron 6000 rotor stator system by 18000 rpm for 20 minutes. The quick cooling of the suspension is ensured by the addition of 150 g of cold water. In 1015 g of the solution, 310 g of ice/water mix (250 g ice/60 g water) is added. Then 26 g gum acacia is added and stirred until dissolved. The final composition of the coating formulation is: 112 g HPMC, 30 g stearic acid, 26 g of gum acacia, 1183 g of demineralised water.

(19) The size of the particles of stearic acid in the suspension are measured with a Coulter N4 Plus at a mean diameter of 0.496 m.

(20) Step 2: Application of the Coating Formulation on the Core Surface

(21) 428.6 g Ropufa 10 n-3 INF Powder are mixed with 71.4 g stearic acid plant (Merck) and heated up to 55-60 C. for 30 minutes. The mix is then cooled down to RT while mixing.

(22) 250 g of the mix is fluidised in a small laboratory fluid bed equipment (DMR, WFP mini) and used as Core particles. 200 g of the coating formulation obtained in the step 1 is sprayed on the surface of the beadlets with a 2-fluid nozzle (air pressure: 1.5 bars) in a top-spray configuration. The spraying time is of about 121 min with an inlet air temperature of 55 C.

(23) The final composition of the product obtained is:

(24) TABLE-US-00003 TABLE 3 Compound of Example 3 Ingredients Wt-% CORE (Ropufa + stearic acid) 91 HPMC 6 Gum acacia 1.4 Stearic acid micronised 1.6

(25) The sensory of these particles were evaluated by sniff test. Sniff test consists in presenting the forms to a panel of judges, ask them to sniff the products and then rate some given characteristics (sensory descriptors), by the use of an arbitrary scale. In this case it was used a scale from 1 to 7 (1 means the absence of fishiness and 7 an extremely high presence of the fishiness).

(26) Ropufa 10 n-3 INF Powder (non coated form)

(27) Between slightly fishy (level 3) and middle intense fishy (level 4)

(28) Compound of Example 3

(29) Between not detectable (level 1) and very slightly fishy (level 2)

EXAMPLE 4

Coated Particles Comprising Vitamin A

(30) Step 1: Coating Formulation

(31) Same coating formulation as in example 1.

(32) Step 2: Application of the Coating Formulation on the Core Surface

(33) 300 g of a beadlet Vitamin A form (as described in patent WO 2007/045488 and containing 26% Vitamin A, 45% gum acacia senegal, 19% maltodextrin, 10% starch) is fluidised in a small laboratory fluid bed equipment (DMR, WFP mini) and used as Core particles. 270 g of the coating formulation obtained in the step 1 is sprayed on the surface of the beadlets with a 2-fluid nozzle (air pressure: 1.5 bars) in a bottom-spray configuration. The spraying time is of about 105 min with an inlet air temperature of 80 C. 50 g of the obtained product is then mixed with 16.7 g of candelilla wax and heated up to 80 C. for 20 minutes. The mixed is then cooled to RT by mixing.

(34) The final composition of the product obtained is:

(35) TABLE-US-00004 TABLE 4 Compound of Example 4 Ingredients Wt-% CORE 69.9 HPMC 2.6 Gum acacia 1.0 Stearic acid micronised 1.5 Candelilla wax 25