Combinations of alkylamidothiazoles and preservatives

Abstract

Disclosed are active ingredient combinations of alkylamidothiazoles and one or more cosmetically or dermatologically acceptable preservatives.

Claims

1. An active ingredient combination of one or more alkylamidothiazoles and one or more cosmetically or dermatologically acceptable preservatives, wherein the one or more alkylamidothiazoles comprise at least one compound of formula ##STR00028## in which R.sup.1, R.sub.2, X and Y are different, partly identical or completely identical and, independently of one another, represent: R.sup.1=C.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24-alkenyl (linear and branched), C.sub.1-C.sub.8-cycloalkyl, C.sub.1-C.sub.8-cycloalkyl-alkylhydroxy, C.sub.1-C.sub.24-alkylhydroxy (linear and branched), C.sub.1-C.sub.24 alkylamine (linear and branched), C.sub.1-C.sub.24-alkylaryl (linear and branched), C.sub.1-C.sub.24-alkylaryl-alkyl-hydroxy (linear and branched), C.sub.1-C.sub.24-alkylheteroaryl (linear and branched), C.sub.1-C.sub.24-alkyl-OC.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24 alkyl-morpholine, C.sub.1-C.sub.24 alkyl-piperidine, C.sub.1-C.sub.24 alkyl-piperazino, C.sub.1-C.sub.24 alkyl-piperazino-N-alkyl; R.sub.2=H, C.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24-alkenyl (linear and branched), C.sub.1-C.sub.8-cycloalkyl, C.sub.1-C.sub.24-hydroxyalkyl (linear and branched), C.sub.1-C.sub.24-alkylaryl (linear and branched), C.sub.1-C.sub.24-alkylheteroaryl (linear and branched); X=mono- or polysubstituted phenyl; Y=H, C.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24-alkenyl (linear and branched), C.sub.1-C.sub.8-cycloalkyl, C.sub.1-C.sub.24-aryl, C.sub.1-C.sub.24-heteroaryl, C.sub.1-C.sub.24-alkylaryl (linear and branched), C.sub.1-C.sub.24-alkylheteroaryl (linear and branched), -aryl, -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl, COO-alkyl, COO-alkenyl, COO-cycloalkyl, COO-aryl, COO-heteroaryl; and wherein the one or more alkylamidothiazoles are present as free base and/or as cosmetically and dermatologically acceptable salt thereof.

2. The active ingredient combination of claim 1, wherein X represents 2,4-dihydroxyphenyl, 2,3-dihydroxyphenyl, 2,4-dimethoxyphenyl, or 2,3-dimethoxyphenyl.

3. The active ingredient combination of claim 1, wherein the one or more alkylamidothiazoles comprise one or more alkylamidothiazoles of formula ##STR00029## in which the substituents Z independently represent H, OH, F, Cl, Br, I, -OMe, NH.sub.2, CN, acetyl.

4. The active ingredient combination of claim 3, wherein the one or more alkylamidothiazoles comprise one or more alkylamidothiazoles of formula ##STR00030## in which the substituent Z represents H, OH, F, Cl, Br, I, -OMe, NH.sub.2, CN.

5. The active ingredient combination of claim 1, wherein the combination comprises one or more alkylamidothiazoles of formula ##STR00031## in which ##STR00032## Y=H; R.sup.1=C.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24-alkenyl (linear and branched), C.sub.1-C.sub.8-cycloalkyl, C.sub.1-C.sub.8-cycloalkyl-alkylhydroxy, C.sub.1-C.sub.24 alkylhydroxy (linear and branched), C.sub.1-C.sub.24 alkylamine (linear and branched), C.sub.1-C.sub.24-alkylaryl (linear and branched), C.sub.1-C.sub.24-alkylaryl-alkyl-hydroxy (linear and branched), C.sub.1-C.sub.24-alkylheteroaryl (linear and branched), C.sub.1-C.sub.24-alkyl-OC.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24-alkyl-morpholino, C.sub.1-C.sub.24 alkyl-piperidine, C.sub.1-C.sub.24 alkyl-piperazine, C.sub.1-C.sub.24 alky-piperazino-N-alkyl; R.sub.2=H, C.sub.1-C.sub.24-alkyl (linear and branched); Z=H, OH, F, Cl, Br, I, -OMe, NH.sub.2, CN, acetyl.

6. The active ingredient combination of claim 1, wherein the combination comprises one or more alkylamidothiazoles of formula ##STR00033## in which ##STR00034## Y=H; R.sup.1=C.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24-alkenyl (linear and branched), C.sub.1-C.sub.8-cycloalkyl, C.sub.1-C.sub.8-cycloalkyl-alkylhydroxy, C.sub.1-C.sub.24-alkylhydroxy (linear and branched), C.sub.1-C.sub.24 alkylamine (linear and branched), C.sub.1-C.sub.24-alkylaryl (linear and branched), C.sub.1-C.sub.24-alkyl-aryl-alkyl-hydroxy (linear and branched), C.sub.1-C.sub.24-alkylheteroaryl (linear and branched), C.sub.1-C.sub.24-alkyl-OC.sub.1-C.sub.24-alkyl (linear and branched), C.sub.1-C.sub.24 alkyl-morpholine, C.sub.1-C.sub.24 alkyl-piperidine, C.sub.1-C.sub.24 alkyl-piperazine, C.sub.1-C.sub.24 alkyl-piperazino-N-alkyl; R.sub.2=H.

7. The active ingredient combination of claim 1, wherein the combination comprises one or more of the following alkylamidothiazoles: ##STR00035## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamide ##STR00036## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide ##STR00037## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)butyramide ##STR00038## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)heptanamide ##STR00039## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-6-hydroxyhexanamide ##STR00040## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-3-hydroxypropanamide ##STR00041## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-methoxyacetamide ##STR00042## 3-amino-N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)propanamide ##STR00043## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)acetamide ##STR00044## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexanecarboxamide ##STR00045## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)cyclohexanecarboxamide and ##STR00046## N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-(4-(hydroxymethyl)phenyl)acetamide.

8. The active ingredient combination of claim 1, wherein the combination comprises one or more alkylamidothiazoles in the form of a cosmetically and dermatologically acceptable salt, which salt is selected from one or more of a halide, a carbonate, an ascorbate, a sulfate, an acetate, a phosphate.

9. The active ingredient combination of claim 1, wherein the one or more preservatives comprise one or more of ethylparaben, propylparaben, methylisothiazolinone, methylpropanediol, butylene glycol, propylene glycol, ethylhexylglycerol, sodium benzoate, 1,2-hexanediol, 1,3-butanediol, 1,2-octanediol, potassium sorbate, 1,3-dimethylol-5,5-dimethyl hydantoin, benzyl alcohol, phenoxyethanol, dehydroacetic acid, piroctone olamine, methylparaben, alcohol, octanehydroxamic acid, benzethonium chloride, glyceryl caprylate, pentylene glycol, lauroyl ethyl arginate, salicylic acid, benzoic acid, propionic acid, sorbic acid.

10. The active ingredient combination of claim 1, wherein the one or more preservatives comprise one or more of salicylic acid, benzoic acid, dehydroacetic acid, as such and/or in the form of physiologically acceptable water-soluble metal salts thereof.

11. The active ingredient combination of claim 1, wherein the one or more preservatives comprise one or more of methylisothiazolinone, potassium sorbate, sodium benzoate, ethylhexylglycerol, benzyl alcohol, benzethonium chloride.

12. The active ingredient combination of claim 1, wherein the one or more preservatives comprise ethylhexylglycerol.

13. The active ingredient combination of claim 1, wherein the combination comprises more than one alkylamidothiazole.

14. The active ingredient combination of claim 1, wherein the one or more alkylamidothiazoles comprise N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamide.

15. The active ingredient combination of claim 1, wherein the one or more alkylamidothiazoles comprise N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide.

16. The active ingredient combination of claim 1, wherein the one or more alkylamidothiazoles comprise N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)butyramide.

17. The active ingredient combination of claim 1, wherein the one or more alkylamidothiazoles comprise N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)cyclohexanecarboxamide.

18. The active ingredient combination of claim 14, wherein the one or more preservatives comprise ethylhexylglycerol.

19. The active ingredient combination of claim 15, wherein the one or more preservatives comprise ethylhexylglycerol.

20. The active ingredient combination of claim 16, wherein the one or more preservatives comprise ethylhexylglycerol.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) The examples below are intended to illustrate the present invention without limiting it. Unless stated otherwise, all of the quantities, fractions and percentages stated are based on the weight and the total amount or on the total weight of the preparations.

FORMULATION EXAMPLES

O/W Emulsions

(2) TABLE-US-00002 Formulation example 1 2 3 4 % by % by % by % by Chemical/INCI name wt. wt. wt. wt. Stearic acid 2.50 2.00 2.00 2.50 Glyceryl stearate 1.00 1.00 1.00 1.00 C12-15 alkyl benzoate 3.00 5.00 3.00 2.00 Caprylic/capric triglyceride 2.50 2.50 2.00 2.50 Isopropyl palmitate 2.00 2.00 Cetylstearyl alcohol 3.00 2.00 3.00 Cetyl alcohol 2.00 Stearyl alcohol 2.00 1.00 C13-16 Isoparaffin 1.00 Dibutyl adipate 1.50 Cyclomethicone 1.00 1.00 0.50 Dicaprylyl carbonate 2.00 2.00 2.00 2.00 Dimethicone 1.00 0.50 1.00 Glycerol 5.00 7.00 5.00 9.00 Ethylhexyl cocoate 1.00 Methylparaben 0.20 Phenoxyethanol 0.40 0.50 0.50 0.40 Propylparaben 0.10 0.10 1,2-Hexanediol 0.10 0.10 Ethylhexylglycerol 0.20 Methylisothiazolinone 0.05 Butylene glycol 2.0 Carbomer 0.15 0.10 0.15 0.10 Carrageenan 0.10 0.10 Xanthan Gum 0.10 Acrylates/C10-30 Alkyl Acrylate 0.10 0.10 Crosspolymer Trisodium EDTA 0.20 0.20 0.20 0.20 Tapioca starch 1.50 1.00 Nylon-12 (1,8-diazacyclo- 0.20 0.50 tetradecane-2,7-dione homopolymer) Polymethylsilsesquioxane 1.00 1.00 Aluminum starch 1.00 octenylsuccinate Distarch phosphate 1.00 1.00 1.00 Butylmethoxydibenzoylmethane 1.00 2.00 1.00 1.00 Phenylbenzimidazolesulfonic acid 1.00 1.00 2.00 2.00 Octocrylene 2.00 2.00 1.00 2.00 Ethylhexyl salicylate 1.00 1.00 2.00 1.00 Sodium benzoate 0.01 0.05 0.10 0.15 Dehydroacetic acid 0.10 0.05 0.20 0.03 Hydroxypropyltetrahydro- 1.00 0.50 pyranetriol Lipoic acid 0.50 0.20 Potassium methoxysalicylate 0.30 0.10 0.05 Vitamin B6 HCl 0.10 0.05 0.30 Tranexamic acid 0.01 0.25 Pyrus Malus Stem Extract 1.00 0.25 0.50 0.75 N-(4-(2,4-Dihydroxy- 0.20 0.10 0.05 0.30 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.01 0.25 0.15 0.10 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.25 0.15 0.30 0.35 phenyl)thiazol-2- yl)butyramide N-(4-(2,4-Dihydroxy- 0.10 0.10 0.15 0.20 phenyl)thiazol-2- yl)cyclohexancarboxamide Sodium hydroxide q.s. q.s. q.s. q.s. Hydroxyisohexyl 3- 0.10 0.05 cyclohexenecarboxaldehyde Citronellol 0.05 0.10 0.05 Linalool 0.05 0.10 Perfume 0.30 0.20 0.20 0.20 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation example 5 6 7 8 % by % by % by % by Chemical name wt. wt. wt. wt. Glyceryl stearate citrate 2.00 1.50 2.00 2.00 Behenyl alcohol 1.50 1.00 1.00 1.00 C12-15 Alkyl benzoate 2.00 2.50 2.00 2.50 Caprylic/capric triglyceride 2.00 2.00 2.50 2.50 Cetyl alcohol 2.00 2.00 2.00 Cetylstearyl alcohol 2.00 Cyclopentasiloxane 1.00 Cyclomethicone 1.00 1.00 2.00 2.00 Dicaprylyl carbonate 2.00 2.50 2.50 Paraffinum Liquidum (mineral oil) 0.50 Octyldodecanol 2.00 Isopropyl palmitate 1.50 Dimethicone 0.50 1.00 1.00 Glycerol 3.00 5.00 7.00 9.00 Methylparaben 0.20 0.15 Phenoxyethanol 0.40 0.60 0.50 0.50 Propylparaben 0.10 Methylisothiazolinone 0.05 Piroctone olamine 0.15 Sodium benzoate 0.10 0.10 0.10 0.10 Glyceryl caprylate 0.20 Ethylparaben 0.10 Carbomer 0.20 0.15 0.15 Sodium polyacrylate 0.40 Xanthan gum 0.10 0.10 Acrylates/C10-30 Alkyl Acrylate 0.10 0.10 Crosspolymer Tapioca starch 0.50 0.50 Nylon-12 (1,8-Diazacyclo- 1.00 1.00 tetradecane-2,7-dione homopolymer) Polymethylsilsesquioxane 1.00 1.00 Aluminum starch 1.00 1.00 octenylsuccinate N-(4-(2,4-Dihydroxy- 0.25 0.15 0.30 0.35 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.10 0.10 0.15 0.20 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.01 0.25 0.15 0.10 phenyl)thiazol-2- yl)butyramide N-(4-(2,4-Dihydroxy- 0.20 0.10 0.05 0.30 phenyl)thiazol-2- yl)cyclohexanecarboxamide Glycyrrhiza Inflata 0.03 0.05 0.05 0.03 Root Extract Titanium dioxide 1.00 Octocrylene 1.00 2.00 1.00 1.00 Bis-Ethylhexyloxyphenol 1.00 1.00 2.00 2.00 Methoxyphenyl Triazine 2-Ethylhexylmethoxycinnamate 2.00 2.00 1.00 2.00 Homosalate (3,3,5-Trimethyl- 1.00 1.00 2.00 1.00 cyclohexyl salicylate) Sodium hydroxide q.s. q.s. q.s. q.s. Trisodium EDTA 0.15 0.15 1-(1,2,3,4,5,6,7,8-octahydro- 0.1 q.s. q.s. 2,3,8,8,-tetramethyl-2- naphthyl)ethan-1-one Geraniol 0.05 Hexylcinnamal 0.05 Perfume 0.10 0.20 0.30 0.20 Water ad 100 ad 100 ad 100 ad 100 Formulation examples 9 10 11 12 % by % by % by % by Chemical name wt. wt. wt. wt. Polyglyceryl-3 Methylglucose 2.00 2.50 2.50 2.50 Distearate Sorbitan Stearate 1.50 3.00 1.50 3.00 C12-15 Alkyl benzoate 2.50 2.50 2.50 2.50 Caprylic/capric triglycerides 2.50 2.50 2.50 2.50 Stearyl alcohol 1.00 1.50 1.00 1.50 Cyclomethicone 3.00 1.00 2.00 1.00 Isopropyl myristate 2.50 2.00 2.50 Isopropyl palmitate 2.00 1.00 Ethylhexyl stearate 1.50 Dimethicone 1.00 1.00 Decyl Oleate 1.50 Glycerol 5.00 7.50 3.00 7.50 Butyrospermum Parkii Butter 2.00 Squalane 0.50 Sodium benzoate 0.10 0.10 0.10 0.10 Methylparaben 0.20 0.20 0.10 Phenoxyethanol 0.40 0.40 0.40 0.40 Propylparaben 0.10 Benzethonium chloride 0.10 Caprylyl glycol 0.20 Ethylhexylglycerol 0.20 0.2 Pentylene glycol 0.10 0.05 0.5 Carbomer 0.15 0.10 0.15 0.10 Ammonium Acryloyldimethyl- 0.20 0.20 taurate/VP Copolymer Carrageenan 0.10 0.15 Trisodium EDTA 1.00 1.00 Tapioca starch 1.00 1.00 Distarch phosphate 1.00 1.00 Acrylonitrile-methacrylonitrile- 1.00 1.00 methyl-methacrylate Copolymer + Isopentane + Magnesium Hydroxide N-(4-(2,4-Dihydroxy- 0.01 0.25 0.15 0.10 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.20 0.10 0.05 0.30 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.25 0.15 0.30 0.35 phenyl)thiazol-2- yl)butyramide N-(4-(2,4-Dihydroxy- 0.10 0.10 0.15 0.20 phenyl)thiazol-2- yl)cyclohexanecarboxamide Diethylamino Hydroxybenzoyl 1.00 2.00 1.00 1.00 Hexyl Benzoate Ethylhexyl methoxycinnamate 1.00 1.00 2.00 2.00 Butylmethoxydibenzoylmethane 2.00 2.00 1.00 2.00 Octocrylene 1.00 1.00 2.00 1.00 Titanium dioxide 1.00 Sodium hydroxide q.s. q.s. q.s. q.s. Ubiquinone 0.10 Sodium metabisulfite 0.15 BHT (tert-butylhydroxytoluene) 0.05 Linalyl acetate 0.05 Hexyl salicylate 0.05 Benzyl salicylate 0.01 Perfume q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 13 14 15 16 % by % by % by % by Chemical name wt. wt. wt. wt. PEG-40 Stearate 0.80 1.00 1.00 1.00 Glyceryl Stearate 2.50 3.00 3.00 3.00 C12-15 Alkyl Benzoate 2.00 2.50 2.00 2.00 Caprylic/capric triglyceride 2.00 2.50 2.50 2.00 Cetylstearyl alcohol 3.00 3.00 3.00 3.00 Cyclomethicone 2.00 2.00 2.00 2.00 Dicaprylyl carbonate 2.00 2.50 2.50 Octyldodecanol 1.00 1.50 Triisostearin 0.50 1.00 Butyrospermum Parkii Butter 2.00 Octyldodecyl myristate 1.00 1.50 1.00 Dimethicone 1.00 1.00 1.00 1.00 Glycerol 7.50 5.00 9.0 7.50 Methylparaben 0.20 0.10 Phenoxyethanol 0.40 0.50 0.40 0.40 Propylparaben 0.10 Glyceryl caprylate 0.25 Pentylene glycol 0.50 Butylene glycol 3.00 Lauroyl ethyl arginate 0.10 0.05 0.20 Potassium sorbate 0.10 0.05 0.15 0.01 Sodium salicylate 0.01 0.02 0.01 0.05 Carbomer 0.15 0.10 0.10 0.15 Sodium polyacrylate 0.20 0.20 Xanthan gum 0.10 Acrylates/C10-30 Alkyl Acrylate 0.1 Crosspolymer Trisodium EDTA + water 1.00 1.00 1.00 (20% strength aqueous solution) Tapioca starch 1.00 1.00 1.00 Distarch phosphate 1.00 1.00 1.00 Aluminum starch 2.00 octenylsuccinate Acrylonitrile-methacrylonitrile- 1.00 methyl-methacrylate Copolymer + Isopentane + Magnesium Hydroxide N-(4-(2,4-Dihydroxy- 0.10 0.15 0.10 0.01 phenyl)thiazol-2-yl)- isobutyramide Ethylhexyl methoxycinnamate 1.00 2.00 1.00 1.00 Diethylamino Hydroxybenzoyl 0.50 1.00 2.00 1.00 Hexyl Benzoate Homosalate (3,3,5-Trimethyl- 2.00 2.00 1.00 2.00 cyclohexyl salicylate) Phenylbenzimidazolesulfonic acid 1.00 1.00 2.00 1.00 Titanium dioxide 1.00 Glyceryl Glucoside 3.00 Short-chain hyaluronic acid 0.10 Long-chain hyaluronic acid 0.10 4-Butylresorcinol 0.30 Magnolia bark extract 0.10 Octadecenedioic acid 0.05 Folic acid 0.01 Carnitine 0.50 Creatine 0.10 Alpha-Glucosylrutin 0.01 Taurine 0.10 Mulberry root extract 0.20 Sodium metabisulfite 0.10 Diethylhexyl 0.13 0.13 syringylidenemalonate Sodium hydroxide q.s. q.s. q.s. q.s. 3-Methyl-5-phenyl-1-pentanol 0.10 Coumarin 0.05 Ethyllinalool 0.10 Ascorbyl palmitate 0.10 Perfume q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 17 18 19 20 % by % by % by % by Chemical name wt. wt. wt. wt. Glyceryl Stearate Citrate 2.00 2.00 2.00 2.00 Isopropyl Palmitate 3.00 2.00 3.00 1.00 Cetylstearyl alcohol 4.00 3.00 3.00 Cetyl alcohol 4.00 Caprylic/capric triglyceride 3.00 2.50 2.00 3.00 C12-15 Alkyl benzoate 3.00 2.50 2.00 2.00 Cyclomethicone 1.00 1.00 Dicaprylyl carbonate 2.50 Dimethicone 0.50 Octyldodecyl myristate 1.00 Glycerol 4.00 6.00 5.00 6.00 Methylparaben 0.20 0.10 Phenoxyethanol 0.40 0.40 0.40 0.40 Piroctone olamine 0.10 Ethylhexylglycerol 0.30 Glyceryl Caprylate 0.30 2-Methyl-1,3-propanediol 2.00 2.00 Sodium benzoate 0.01 0.20 0.10 Sodium salt of dehydroacetic acid 0.01 0.05 0.10 0.02 Carbomer 0.20 0.10 0.15 Sodium polyacrylate 0.40 Xanthan gum 0.10 0.15 Acrylates/C10-30 Alkyl Acrylate 0.10 0.20 Crosspolymer Acrylonitrile-methacrylonitrile- 0.50 0.50 methyl-methacrylate Copolymer + Isopentane + Magnesium Hydroxide Aluminum starch octenylsuccinate 1.00 1.00 Methyl Methacrylate Crosspolymer 1.00 1.00 Glycyrrhiza Inflata root extract 0.03 Vitamin C/Ascorbic acid 3.00 Glycine soya germ extract 0.50 Arctium Lappa root extract 0.30 Pimpinella Anisum fruit extract 4.00 Glycyrrhitic acid 0.10 N-Acetylhydroxyproline 0.10 Niacinamide 0.20 Magnesium ascorbylphosphate 0.10 Ellagic acid 0.01 Liquorice root extract 0.10 Seasalt 0.05 Isoserinol 1.00 Dihydroxypropyltrimonium 0.80 chloride N-(4-(2,4-Dihydroxy- 0.25 0.30 0.01 0.05 phenyl)thiazol-2- yl)isobutyramide Titanium dioxide 1.00 1.00 Bis-Ethylhexyloxyphenol 1.00 2.00 1.00 1.00 Methoxyphenyl Triazine Octocrylene 1.00 1.00 2.00 2.00 Butyl Methoxydibenzoylmethane 2.00 2.00 1.00 2.00 Ethylhexyl Salicylate 1.00 1.00 2.00 1.00 Citronellol 0.05 0.05 Coumarin 0.05 0.05 0.05 Triethyl citrate 0.05 0.05 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 21 22 23 24 % by % by % by % by Chemical name wt. wt. wt. wt. Sucrose Polystearate + 1.00 1.00 2.00 2.00 Hydrogenated Polyisobutene Sodium stearoyl glutamate 0.20 0.20 0.30 0.30 C12-15 Alkyl benzoate 1.50 1.50 Cetyl alcohol 0.50 0.50 Cyclomethicone 10.00 10.00 5.00 5.00 Dimethicone 3.00 3.00 2.50 2.50 Glycerol 7.50 7.50 5.00 5.00 Isopropyl stearate 1.00 1.00 2.00 2.00 Paraffinum Liquidum (mineral oil) 3.00 3.00 1.00 1.00 Methylparaben 0.10 0.10 Ethylhexylglycerol 0.30 0.10 Propylparaben 0.10 Methylisothiazolinone 0.05 Phenoxyethanol 0.40 0.50 0.40 0.40 Potassium sorbate 0.10 0.05 0.20 0.01 Ascorbyl glucoside 0.10 Undecenoylphenylalanine 0.50 Kojic acid 0.10 Arbutin 0.01 Betaine 0.20 N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.10 0.25 0.15 0.10 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.15 0.15 0.01 0.06 phenyl)thiazol-2- yl)butyramide Ethylhexyl methoxycinnamate 1.00 2.00 1.00 1.00 Butylmethoxydibenzoylmethane 1.00 1.00 2.00 2.00 Phenylbenzimidazolesulfonic acid 2.00 2.00 1.00 2.00 Acrylates/octylacrylamide 1.00 copolymer Butylene glycol 3.00 Polymethylsilsesquioxane 1.00 1.00 Prunus Amygdalus Dulcis Oil 1.00 Nylon-12 (1,8-Diazacyclo- 1.00 1.00 tetradecane-2,7-dione Homopolymer) Distarch phosphate 1.00 1.00 Methyl methacrylate crosspolymer 1.00 Aluminum starch octenylsuccinate 1.00 Ammonium Acryloyldimethyl- 0.25 0.25 taurate/VP Copolymer Xanthan gum 0.10 0.10 Acrylates/C10-30 Alkyl Acrylate 0.25 0.10 Crosspolymer Carbomer 0.10 0.10 Hexylcinnamal 0.05 0.10 0.10 1-(1,2,3,4,5,6,7,8-octahydro- 0.10 0.10 2,3,8,8,-tetramethyl-2- naphthyl)ethan-1-one Linalool 0.05 0.05 Perfume 0.20 0.20 0.20 0.20 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 25 26 27 28 % by % by % by % by Chemical name wt. wt. wt. wt. Sodium cetearyl sulfate 0.15 0.15 0.15 Glyceryl Stearate SE 2.00 2.00 1.50 Sodium Stearoyl Glutamate 0.30 C12-15 Alkyl benzoate 2.50 2.50 2.50 2.50 Octyldodecanol 1.00 1.00 Caprylic/capric triglyceride 2.00 2.00 2.00 2.00 Cetylstearyl alcohol 2.00 2.00 3.00 1.00 Cyclomethicone 1.50 1.50 2.50 2.50 Glyceryl Stearate 2.00 Dimethicone 0.50 0.50 0.50 0.50 Glycerol 5.00 5.00 7.50 7.50 Cetearyl alcohol 1.00 1.50 1.00 1.00 Isopropyl stearate 3.00 3.00 2.00 2.00 Paraffinum Liquidum (mineral oil) 2.00 2.00 1.00 1.00 Methylisothiazolinone 0.05 Phenoxyethanol 0.40 0.50 0.40 0.30 Methylparaben 0.15 Propylparaben 0.10 Piroctone olamine 0.15 Benzethonium chloride 0.10 Octanehydroxamic acid 0.10 0.10 0.50 Sodium benzoate 0.05 0.20 0.10 N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.25 0.30 0.01 0.05 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.10 0.25 0.15 0.10 phenyl)thiazol-2- yl)butyramide N-(4-(2,4-Dihydroxy- 0.15 0.15 0.01 0.06 phenyl)thiazol-2- yl)cyclohexanecarboxamide Ethylhexylmethoxycinnamate 1.00 2.00 1.00 1.00 Butylmethoxydibenzoylmethane 1.00 1.00 2.00 2.00 Pentylene glycol 1.00 1.00 Butylene glycol 1.00 1.50 3.00 3.00 Dipropylene glycol 0.50 1.00 0.80 0.10 2-Methyl-1,3-propanediol 1,2-Hexanediol 1.00 Nylon-12 (1,8-Diazacyclo- 1.00 1.00 1.00 1.00 tetradecane-2,7-dione Homopolymer) Carbomer 0.10 0.15 Ammonium Acryloyldimethyl- 0.20 taurate/VP Copolymer Chondrus Crispus 0.10 0.10 Xanthan gum 0.10 Acrylates/C10-30 Alkyl 0.20 0.10 0.10 Acrylate Crosspolymer Coumarin 0.10 0.05 0.05 Hydroxyisohexyl 3-Cyclo- 0.05 0.05 0.05 0.10 hexenecarboxaldehyde 1-(1,2,3,4,5,6,7,8- 0.05 0.10 octahydro-2,3,8,8,- tetramethyl-2- naphthyl)ethan-1-one Perfume 0.20 0.30 0.40 0.20 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 29 30 31 32 % by % by % by % by Chemical/INCI name wt. wt. wt. wt. Sodium cetearylsulfate 0.15 0.15 0.20 0.20 Glyceryl stearate, self- 2.00 2.00 1.50 1.50 emulsifying C12-15 Alkyl benzoate 2.00 2.00 2.00 2.00 Octyldodecanol 1.00 1.00 Caprylic/capric triglyceride 2.00 2.00 2.00 2.00 Cetylstearyl alcohol 2.00 2.00 1.00 1.00 Cyclomethicone 1.00 1.00 2.00 2.00 Dimethicone 0.50 0.50 1.00 1.00 Glycerol 5.00 5.00 7.50 7.50 Isopropyl palmitate 2.50 2.50 2.00 2.00 DMDM Hydantoin 0.05 0.05 0.05 0.05 Phenoxyethanol 0.35 0.25 0.30 0.30 Ethanol 3.00 2.00 Pentylene glycol 1.00 1.00 1.50 Potassium sorbate 0.10 0.30 0.05 Zingerone 0.10 Dihydromyricetin 0.03 White tea extract 1.00 4-Hexylresorcinol 0.30 Phenylethylresorcinol 0.50 Ubiquinone 0.10 Cyanomethylphenylmenthane- 0.10 carboxamide Menthoxypropanediol 0.10 Menthanecarboxamide 0.10 ethylpyridine Hydroxyethylurea 0.50 Urea 1.00 N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide Carbomer 0.20 0.20 0.20 0.20 Carrageenan 0.10 0.10 Xanthan gum 0.20 0.20 Acrylates/C10-30 Alkyl Acrylate 0.15 Crosspolymer Sodium Polyacrylate 0.20 Diethylhexyl 2,6-naphthalate 1.00 Phenylbenzimidazolesulfonic acid 1.00 2.00 1.00 1.00 Titanium dioxide 1.00 1.00 2.00 2.00 Diethylamino Hydroxybenzoyl 2.00 2.00 1.00 2.00 Hexyl Benzoate Octocrylene 1.00 1.00 2.00 1.00 3,3,5-Trimethylcyclohexyl 1.00 salicylate Distarch phosphate 1.00 1.00 Methyl methacrylate crosspolymer 1.00 1.00 Polymethylsilsesquioxane 1.00 1.00 Acrylonitrile-methacrylonitrile- 1.00 1.00 methyl-methacrylate Copolymer + Isopentane + Magnesium Hydroxide 1-(1,2,3,4,5,6,7,8-octahydro- 0.10 0.10 0.05 2,3,8,8,-tetramethyl-2- naphthyl)ethan-1-one Hydroxyisohexyl 3-cyclo- 0.05 0.05 0.10 hexenecarboxaldehyde Linalyl acetate 0.10 0.05 0.05 Perfume 0.15 0.15 0.30 0.30 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 33 34 35 36 % by % by % by % by Chemical/INCI name wt. wt. wt. wt. Sodium cetearylsulfate 0.15 0.15 0.15 0.15 Glyceryl stearate, self- 1.00 1.00 1.00 1.00 emulsifying C12-15 Alkyl benzoate 2.00 2.50 2.00 2.00 Isopropyl palmitate 3.50 3.00 2.50 3.50 Dimethicone 1.00 1.00 1.00 1.0 Cetylstearyl alcohol 1.00 1.00 1.00 1.00 Octyldodecyl Myristate 1.00 Butyrospermum Parkii Butter 1.00 Glycerol 7.00 3.00 9.00 5.00 Carbomer 0.10 0.15 0.10 0.10 Acrylates/C10-30 Alkyl Acrylate 0.15 0.10 0.10 0.15 Crosspolymer Xanthan gum 0.15 0.15 0.15 0.15 Phenylbenzimidazolesulfonic acid 1.00 1.00 0.50 1.00 Butylmethoxydibenzoylmethane 1.50 1.50 1.50 1.50 Ethylhexyl salicylate 2.00 2.50 2.50 2.50 Octocrylene 1.50 1.50 2.50 1.50 Titanium dioxide + 1.00 1.00 trimethoxycaprylylsilane Aluminum starch octenylsuccinate 1.00 0.50 Methyl methacrylate crosspolymer 0.50 0.50 Nylon-12 (1,8-Diazacyclo- 0.50 1.00 tetradecane-2,7-dione Homopolymer) Tapioca starch 0.50 0.50 1.00 Phenoxyethanol 0.50 0.50 0.50 0.40 Ethylhexylglycerol 0.25 0.25 1,2-Hexanediol 1.00 3.00 Caprylyl glycol 0.30 0.30 2-Methyl-1,2-propanediol 2.00 2.00 2.00 1,3- Butanediol 0.01 0.20 Sodium benzoate 0.10 0.20 N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.25 0.30 0.01 0.05 phenyl)thiazol-2- yl)pivalamide Ethyllinalool 0.05 0.05 3-Methyl-5-phenyl-1-pentanol 0.05 0.05 Geraniol 0.05 0.05 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 37 38 39 40 % by % by % by % by Chemical/INCI name wt. wt. wt. wt. Polyglyceryl-10 stearate 0.20 0.20 0.20 0.20 Glyceryl stearate 3.00 0.50 0.50 0.50 C12-15 Alkyl benzoate 4.00 2.00 1.50 2.50 Isopropylpalmitate 4.00 1.00 2.00 2.50 Caprylic/capric triglyceride 4.00 3.00 2.00 2.50 Hydrogenated cocoglycerides 3.00 2.00 Butyrospermum Parkii Butter 3.00 2.50 Cetylstearyl alcohol 5.00 3.50 4.00 3.00 Paraffinum Liquidum (mineral oil) 1.00 Glycerol 5.00 3.00 7.00 9.00 Acrylates/C10-30 Alkyl Acrylate 0.30 0.20 0.15 0.20 Crosspolymer Methylisothiazolinone 0.05 0.05 Phenoxyethanol 0.50 0.40 0.40 0.40 Carbomer 0.10 0.15 0.10 0.10 Methylparaben 0.10 0.10 Propylparaben 0.10 Benzyl alcohol 0.10 0.10 0.05 0.15 Sodium benzoate 0.50 0.40 0.40 0.40 Nylon-12 (1,8-Diazacyclo- 1.00 0.50 tetradecane-2,7-dione Homopolymer) Polymethylsilsesquioxane 1.00 0.50 Methyl Methacrylate Crosspolymer 1.00 0.50 Tapioca starch 0.50 0.50 N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.25 0.30 0.01 0.05 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.10 0.25 0.15 0.10 phenyl)thiazol-2- yl)butyramide N-(4-(2,4-Dihydroxy- 0.01 0.60 1.00 0.20 phenyl)thiazol-2- yl)cyclohexanecarboxamide Benzophenone-4 1.00 2.00 1.50 0.50 Ethylhexyl Triazone 2.00 0.50 1.00 2.00 Ethanol 3.00 2.00 Geraniol 0.05 0.05 Benzyl salicylate 0.05 0.05 Ethyllinalool 0.05 0.05 Perfume 0.20 0.15 0.30 0.30 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 41 42 43 44 % by % by % by % by Chemical/INCI name wt. wt. wt. wt. Polyglyceryl-10 stearate 0.20 0.20 0.15 0.15 C12-15 Alkyl benzoate 2.50 2.50 2.00 3.00 Isopropyl palmitate 2.50 2.50 2.00 2.00 Caprylic/capric triglyceride 2.00 2.50 1.00 2.00 Glyceryl stearate 1.00 1.00 0.50 0.50 Octyldodecanol 0.50 1.00 Cyclomethicone 0.50 0.50 Butyl Methoxydibenzoylmethane 1.00 2.00 2.00 1.00 Octocrylene 0.50 2.00 3.00 2.00 Ethylhexyl salicylate 2.00 1.00 1.00 1.50 Phenylbenzimidazolesulfonic acid 1.00 1.00 0.50 1.50 Titanium dioxide 1.00 1.00 3,3,5-Trimethylcyclohexyl 1.00 1.00 salicylate Glycerol 9.00 5.00 7.00 7.00 Tapioca starch 1.00 1.00 Acrylonitrile-methacrylonitrile- 1.00 0.50 methyl-methacrylate Copolymer + Isopentane + Magnesium Hydroxide Aluminum starch octenylsuccinate 1.00 1.00 Distarch phosphate 1.00 Methylisothiazolinone 0.05 0.05 Phenoxyethanol 0.50 0.50 0.40 0.40 Benzethonium chloride 0.10 Ethylhexylglycerol 0.10 Methylparaben 0.20 Salicylic acid 0.01 0.05 0.10 0.02 Potassium sorbate 0.10 0.05 0.20 0.30 Carbomer 0.25 0.20 0.20 0.20 Acrylates/C10-30 Alkyl Acrylate 0.20 0.15 Crosspolymer Ammonium Acryloyldimethyl- 0.25 taurate/VP Copolymer Sodium polyacrylate 0.30 Xanthan gum 0.15 N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide Ethanol 3.00 3.00 Butylene glycol 2.00 2.00 Coumarin 0.05 0.05 Hexylcinnamal 0.05 0.05 0.05 Hexyl salicylate 0.05 0.05 Perfume 0.15 0.20 0.25 0.30 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 45 46 47 48 % by % by % by % by Chemical/INCI name wt. wt. wt. wt. Potassium cetylphosphate 0.20 0.20 0.20 0.20 Dicaprylyl carbonate 1.00 C12-15 Alkyl benzoate 2.50 2.00 1.00 3.00 Isopropyl palmitate 2.50 2.00 3.00 1.00 Caprylic/capric triglyceride 2.50 2.00 1.50 2.00 Cera Microcristallina 0.50 Cyclomethicone 0.25 0.50 0.50 Diethylhexyl 2,6-naphthalate 0.50 1.00 Diethylamino Hydroxybenzoyl 1.00 1.00 Hexyl Benzoate Ethylhexyl Salicylate 1.00 0.50 2.00 1.00 Octocrylene 2.00 1.00 3.00 2.00 Glycerol 5.00 7.00 9.00 7.00 Acrylates/C10-30 Alkyl Acrylate 0.10 0.30 0.10 Crosspolymer Sodium polyacrylate 0.30 Carbomer 0.10 0.15 0.15 Ammonium Acryloyldimethyl- 0.25 taurate/VP Copolymer Chondrus Crispus Extract 0.10 (Carrageenan) Methylisothiazolinone 0.05 0.05 Phenoxyethanol 0.50 0.50 0.40 0.40 Piroctone Olamine 0.20 Salicylic acid 0.05 0.10 0.01 0.20 Benzoic acid 0.20 0.05 0.10 0.01 Nylon-12 (1,8-Diazacyclo- 0.50 0.50 0.50 tetradecane-2,7-dione Homopolymer) Distarch phosphate 1.00 0.50 Methyl Methacrylate Crosspolymer 0.50 0.50 Caprylyl glycol 0.30 1,2-Hexanediol 0.50 Butylene glycol 2.00 2.00 DMDM Hydantoin 0.15 Glycyrrhiza Inflata Root Extract 0.05 (liquorice root) N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.25 0.30 0.01 0.05 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.10 0.25 0.15 0.10 phenyl)thiazol-2- yl)butyramide N-(4-(2,4-Dihydroxy- 0.01 0.60 1.00 0.20 phenyl)thiazol-2- yl)cyclohexanecarboxamide Hydroxyisohexyl 3-cyclo- 0.05 0.05 0.05 hexenecarboxaldehyde Citronellol 0.05 0.05 Benzyl salicylate 0.05 0.05 Perfume 0.20 0.20 0.20 0.20 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100 Formulation examples 49 50 51 52 % by % by % by % by Chemical/INCI name wt. wt. wt. wt. Potassium cetylphosphate 0.20 0.20 0.25 0.20 C12-15 Alkyl benzoate 2.50 2.50 2.00 2.00 Isopropyl palmitate 2.50 2.50 3.00 Isopropyl stearate 2.00 Caprylic/capric triglyceride 2.50 2.50 1.50 2.00 Glyceryl stearate 1.00 1.00 1.25 1.50 Octyldodecanol 1.50 Paraffinum Liquidum (mineral oil) 1.00 Glycerol 5.00 7.00 9.00 6.00 Bis-Ethylhexyloxyphenol 1.00 1.00 Methoxyphenyl Triazines Titanium dioxide + 1.00 1.00 trimethoxycaprylylsilane Phenylbenzimidazolesulfonic acid 1.00 2.00 1.00 1.00 Butylmethoxydibenzoylmethane 1.00 1.00 2.00 2.00 Disodiumphenyldibenzimidazole- 2.00 2.00 1.00 2.00 tetrasulfonate Ethylhexyltriazone 1.00 1.00 2.00 1.00 Ethylhexylmethoxycinnamate + 0.50 1.00 0.50 1.00 BHT Carbomer 0.15 0.20 0.30 Acrylates/C10-30 Alkyl Acrylate 0.30 0.10 0.15 Crosspolymer Xanthan gum 0.15 0.10 Methylisothiazolinone 0.05 Phenoxyethanol 0.50 0.50 0.40 0.40 Methylparaben 0.10 Ethylhexyl salicylate 0.30 Butylene glycol 3.00 3.00 Benzethonium chloride 0.10 Sodium benzoate 0.20 0.05 0.10 Propionic acid 0.10 0.20 0.05 0.02 Octanehydroxamic acid 0.20 0.05 0.01 0.30 N-(4-(2,4-Dihydroxy- 0.10 0.10 0.05 0.05 phenyl)thiazol-2- yl)isobutyramide N-(4-(2,4-Dihydroxy- 0.30 0.05 phenyl)thiazol-2- yl)pivalamide N-(4-(2,4-Dihydroxy- 0.15 0.10 phenyl)thiazol-2- yl)butyramide N-(4-(2,4-Dihydroxy- 0.60 1.00 0.20 phenyl)thiazol-2- yl)cyclohexanecarboxamide Coumarin 0.05 0.05 Linalool 0.05 0.05 Hexylcinnamal 0.05 0.05 1-(1,2,3,4,5,6,7,8-octahydro- 0.10 2,3,8,8,-tetramethyl-2- naphthyl)ethan-1-one Perfume 0.10 0.30 0.20 0.30 BHT (tert-butylhydroxytoluene) 0.05 Tocopheryl acetate 0.10 Sodium hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100
W/O Emulsion

(3) TABLE-US-00003 Formulation examples 53 54 Chemical/INCI name % by wt. % by wt. Polyglyceryl-3 diisostearate 1.50 1.50 PEG-40 Sorbitan Perisostearate 2.50 2.50 Lanolin alcohol 0.50 0.50 Paraffinum Liquidum (mineral oil) 8.00 8.00 Cera Microcrystallina 2.50 2.50 Cyclomethicone 4.00 4.00 Isohexadecane 2.00 2.00 Isopropyl palmitate 5.00 5.00 Iodopropynyl butylcarbamate 0.10 Magnesium sulfate 0.5 0.50 Potassium sorbate 0.10 0.05 Benzyl salicylate 0.10 0.01 1,2-Octanediol 0.01 0.05 Sodium benzoate 0.10 0.01 Homosalate 0.50 1.00 Benzophenone-4 2.00 0.50 N-(4-(2,4-Dihydroxyphenyl)thiazol- 0.10 0.10 2-yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 0.05 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.15 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 0.02 yl)cyclohexanecarboxamide Glycerol 7 7 Perfume q.s. q.s. Water ad 100 ad 100
Deodorant/Antiperspirant Example Formulations

(4) TABLE-US-00004 Formulation examples 55 56 57 58 Chemical/INCI name % by wt. % by wt. % by wt. % by wt. Polyethylene glycol(21) stearyl ether 2.50 2.50 1.50 1.50 Polyethylene glycol(2) stearyl ether 1.50 1.50 2.50 2.50 Polypropylene glycol(15) stearyl ether 3.00 3.00 4.00 4.00 Trisodium salt of ethylenediaminetetraacetic 1.50 1.50 1.50 1.50 acid (20% aqueous solution) Persea Gratissima oil (avocado oil) 0.10 0.10 0.15 0.15 Perfume q.s. q.s. q.s. q.s. 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8,- 0.10 0.05 0.05 tetramethyl-2-naphthyl)ethan-1-one Linayl acetate 0.05 0.05 Citronellol 0.05 Triethyl citrate 0.05 Sodium benzoate 0.10 0.02 Potassium sorbate 0.10 0.01 Silver citrate 0.10 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 0.05 0.05 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 0.05 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.15 0.10 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 yl)cyclohexanecarboxamide Water, ad ad 100 ad 100 ad 100 ad 100 Formulation examples 59 60 61 62 Chemical/INCI name % by wt. % by wt. % by wt. % by wt. Isoceteth-20 3.50 3.00 4.00 4.00 Glyceryl isostearate 2.00 2.00 2.00 2.50 Dicaprylyl ether 0.50 2.00 2.50 Caprylic/capric acid ester 2.00 1.50 Aluminum chlorohydrate 5.00 5.00 3.00 Persea Gratissima oil (avocado oil) 0.20 Polyethylene glycol(150) distearate 0.50 0.50 1.00 1.00 Glycerol 4.00 2.00 2.00 Butylene glycol 3.00 1.00 2.00 Propylene glycol 3.00 3.00 4-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1- 0.05 0.10 dimethylpiperidinium bromide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 0.05 0.05 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.05 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.15 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 1.00 0.20 yl)cyclohexanecarboxamide Sodium benzoate 0.10 0.02 Potassium sorbate 0.10 0.01 Geraniol 0.05 Ethyllinalool 0.05 Linalool 0.10 Perfume 0.25 0.50 0.50 0.75 Water, ad ad 100 ad 100 ad 100 ad 100 Formulation examples 63 64 65 66 Chemical/INCI name % by wt. % by wt. % by wt. % by wt. Polyoxyethylene(20) cetylstearyl ether 3.00 3.00 4.00 4.00 Polyoxyethylene(12) cetylstearyl ether 0.50 0.50 Glycerol stearate 3.00 3.00 3.00 3.00 Cetylstearyl alcohol 0.50 0.50 Cetyl palmitate 0.50 0.50 Caprylic/capric acid ester 4.00 4.00 3.50 3.50 Di-n-octyl ether 5.00 5.00 5.00 5.00 Polyethylene glycol(150) distearate 1.00 1.00 Glycerol 4.00 4.00 2.00 2.00 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 0.05 0.05 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 0.30 0.01 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.25 0.15 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 0.60 1.00 yl)cyclohexanecarboxamide 1,3-Butanediol 0.10 0.10 Sorbic acid 0.20 0.01 0.02 0.02 Hexylcinnamal 0.05 0.10 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8,- 0.05 0.10 tetramethyl-2-naphthyl)ethan-1-one 3-Methyl-5-phenyl-1-pentanol 0.05 0.05 Perfume 0.30 0.30 0.50 0.50 Water, ad ad 100.00 ad 100.00 ad 100.00 ad 100.00 Formulation examples 67 68 69 70 Chemical/INCI name % by wt. % by wt. % by wt. % by wt. Steareth-100 1.00 1.00 1.00 1.00 Polyglyceryl-3 diisostearate 1.60 1.60 1.60 1.60 PEG-45/Dodecyl glycol copolymer 0.80 0.80 0.80 0.80 C20-40 alkyl stearate 10.00 10.00 10.00 10.00 Caprylic/capric triglyceride 3.00 3.00 3.00 3.00 Octyldodecanol 3.00 3.00 3.00 3.00 Dicaprylyl ether 4.00 4.00 4.00 4.00 Potassium sorbate 0.10 0.10 0.10 0.10 Ethylhexylglycerol 0.10 0.10 0.10 0.10 Butylene glycol 4.00 4.00 4.00 4.00 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 0.05 0.05 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 0.30 0.05 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.25 0.10 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 0.60 0.20 yl)cyclohexanecarboxamide Hydroxyisohexyl 3-cyclohexenecarboxaldehyde 0.05 0.05 0.05 0.05 Perfume 0.35 0.30 0.25 0.15 Water, ad ad 100.00 ad 100.00 ad 100.00 ad 100.00
Example Formulations

(5) TABLE-US-00005 Formulation examples 71 72 73 74 Chemical/INCI name % by wt. % by wt. % by wt. % by wt. Alcohol denat. 20.0 20.0 30.0 30.0 Hydroxyethylcellulose 0.40 0.40 0.30 0.30 Polyethylene glycol 400 3.00 3.00 2.00 2.00 Polyethylene glycol (2000) hydrogenated castor 2.00 2.00 3.00 3.00 oil Persea Gratissima oil (avocado oil) 0.50 0.50 0.10 0.10 4-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1- 0.10 0.30 dimethylpiperidinium bromide Sodium benzoate 0.01 0.02 0.01 0.02 DMDM Hydantoin 0.02 0.01 0.02 0.01 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 0.05 0.01 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 0.01 0.05 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.15 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 1.00 0.20 yl)cyclohexanecarboxamide Coumarin 0.05 Benzyl salicylate 0.05 Butylphenylmethylpropional 0.05 Perfume 0.25 0.30 0.50 0.30 Water, ad ad 100 ad 100 ad 100 ad 100 Formulation examples 75 76 77 78 Chemical/INCI name % by wt. % by wt. % by wt. % by wt. 2-Octyldodecanol 0.50 0.50 0.50 0.50 1,2-Propylene glycol 1.00 1.00 1.00 1.00 2-Butyloctanoic acid 0.25 0.25 Aluminum chlorohydrate 2.00 3.00 3.00 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 0.05 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 0.30 0.01 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.25 0.15 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 0.60 1.00 yl)cyclohexanecarboxamide Sorbic acid 0.10 0.10 0.10 0.10 Sodium benzoate 0.10 0.10 0.10 0.10 Linalool 0.05 0.05 0.05 Coumarin 0.05 Benzyl salicylate 0.05 0.05 0.05 Perfume 0.10 0.20 0.40 0.20 Ethanol ad 100 ad 100 ad 100 ad 100

(6) The liquid phase obtained by mixing together the respective constituents is poured into aerosol containers with a propane/butane mixture (2.7) in the ratio 39:61.

(7) TABLE-US-00006 Formulation examples 79 80 81 Chemical name % by wt. % by wt. % by wt. Alcohol denat. 20.0 30.0 20.0 Hydroxyethylcellulose 0.40 0.30 0.40 Polyethylene glycol 400 3.00 2.00 3.00 Polyethylene glycol (2000) hydrogenated castor oil 2.00 3.00 2.00 Persea Gratissima oil (avocado oil) 0.50 0.10 0.50 4-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl- 0.05 piperidinium bromide N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)isobutyramide 0.10 0.10 0.05 N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)pivalamide 0.30 0.01 N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)butyramide 0.25 0.15 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.60 1.00 yl)cyclohexanecarboxamide Potassium sorbate 0.20 0.10 0.01 Octanehydroxamic acid 0.01 0.20 0.10 2-Butyloctanoic acid 0.10 Geraniol 0.05 Citronellol 0.05 Ethyllinalool 0.05 Perfume 0.30 0.40 0.20 Water, ad ad 100 ad 100 ad 100 Formulation examples 82 83 84 Chemical name % by wt. % by wt. % by wt. Glycerol monostearate 5.00 5.00 5.00 Polyethylene glycol (2000) monostearate 2.00 2.00 2.00 Stearyl alcohol 3.00 3.00 3.00 Cyclomethicone 4.00 4.00 4.00 Paraffin oil 6.00 6.00 6.00 Trisodium EDTA 0.20 0.20 0.20 Aluminum chlorohydrate 2.50 2.50 2.50 N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)isobutyramide 0.10 0.10 0.05 N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)pivalamide 0.25 0.01 N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)butyramide 0.10 0.15 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 1.00 yl)cyclohexanecarboxamide Sodium benzoate 0.20 0.10 0.10 Methylpropanediol 0.01 0.50 0.60 2-Methylpropanediol 3.00 3.00 3.00 2-Ethylhexyl glycerol ether 0.50 0.50 0.50 Benzyl salicylate 0.05 Triethyl citrate 0.05 Hexylcinnamal 0.05 Perfume 0.40 0.30 0.20 Water, ad 100 100 100
Hair Shampoo

(8) TABLE-US-00007 Example formulation 85 86 Chemical name % by wt. % by wt. Cocamidopropylbetaine 2.50 2.50 Sodium laureth sulfate 9.00 9.00 PEG-40 hydrogenated castor oil 0.50 0.50 Polyquaternium-10 0.20 0.20 PEG-8 0.50 0.10 Sodium benzoate 0.45 0.45 Laureth-9 2.20 2.20 Sodium salicylate 0.20 0.20 Epsilon-poly-L-lysine 0.25 Climbazole 0.45 0.45 Pearlescence 1.50 1.50 Butyl Acrylate/ethyltrimonium chloride 2.50 1.00 methacrylate/styrene copolymer N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol- 0.10 2-yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 yl)cyclohexanecarboxamide Sodium benzoate 0.10 0.15 Perfume 0.30 0.30 Citric acid q.s. q.s. Sodium chloride q.s. q.s. Water ad 100 ad 100
Antidandruff Shampoo

(9) TABLE-US-00008 Example formulation 87 88 Chemical name % by wt. % by wt. Sodium lauryl ether sulfate 9.00 10.00 Cocamidopropylbetaine 4.00 3.00 Disodium PEG-5 lauryl citrate sulfosuccinate 1.00 Thickener 0.20 0.40 Polyquaternium-10 0.30 0.10 Guar hydroxypropyltrimonium chloride 0.20 Potassium sorbate 0.10 0.20 Climbazole 0.50 Epsilon-poly-L-lysine 1.00 0.20 Laureth-9 2.00 Piroctone olamine 1.00 0.50 Selenium sulfide 0.20 Zinc pyrithione 1.00 1.00 Pearlescence 2.50 Opacifier 0.50 PEG-40 hydrogenated castor oil 0.50 0.20 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 yl)cyclohexanecarboxamide Sodium salicylate 0.30 0.20 Sodium benzoate 0.25 0.30 Sodium chloride q.s. q.s. Citric acid q.s. q.s. Perfume q.s. q.s. Water ad 100 ad 100
Hair Tonic

(10) TABLE-US-00009 Example formulation 89 90 Chemical name % by wt. % by wt. Ethanol 30.00 40.00 Panthenol 0.20 0.10 Tocopheryl acetate 0.20 Pentylene glycol 0.10 0.15 C12-13 Alkyl lactate 0.20 0.10 N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 0.10 yl)isobutyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.25 yl)pivalamide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.10 yl)butyramide N-(4-(2,4-Dihydroxyphenyl)thiazol-2- 0.01 yl)cyclohexanecarboxamide Climbazole 0.1 0.1 PEG-40 hydrogenated castor oil 0.3 Perfume, preservative q.s. q.s. Water ad 100 ad 100