Fungicidal penflufen mixtures

Abstract

Fungicidal mixtures having synergistic fungicidal activity may include penflufen and at least one further fungicidal material. The mixtures may be used for protecting industrial materials, and methods for treating industrial materials with the penflufen mixtures are provided.

Claims

1. A synergistic mixture comprising a fungicidal composition for the inhibition of growth of basidiomycetes fungi, the composition comprising: a) penflufen, salts of penflufen, acid addition compounds of penflufen, or any combination thereof; and b) at least one fungicidal compound selected from the group consisting of: o-phenylphenol and its alkali metal and alkaline earth metal salts sodium borate, boric acid, boron oxide, benzalkonium chloride, didecyldimethylammonium chloride, didecylmethylpoly(oxyethyl)ammonium propionate, didecyldimethylammonium carbonate, didecyldimethylammonium bicarbonate or a mixture of didecyldimethylammonium carbonate and didecyldimethylammonium bicarbonate, 4,5-dichloro-N-octylisothiazolin-3-one, 3-iodo-2-propynyl N-butylcarbamate, and N-(3-aminopropyl)-N-dodecyl-1,3-propanediamine, wherein components a) and b) are present in the composition at a weight ratio a):b) effective for providing fungicidal synergy against at least basidiomycetes fungi.

2. The composition according to claim 1, wherein the weight ratio effective for providing fungicidal synergy is a weight ratio of a) to b) of 1:50 to 50:1.

3. The composition according to claim 1, wherein the basidiomycetes fungi comprise Gloeophyllum trabeum, Poria placenta, Coriolus versicolor, Stereum sanguinolentum, and Coniophora puteana.

4. The composition according to claim 3, wherein the weight ratio effective for fungicidal synergy is a weight ratio of 1:20 to 20:1.

5. The fungicide according to claim 1, wherein the weight ratio of a) to b) is 10:1 to 1:10.

6. The composition according to claim 5, wherein the components a) and b) are present in at least the following weight ratios of a) to b): 9:1 to 1:9 with 3-iodo-2-propynyl N-butylcarbamate, 4,5-dichloro-N-octylisothiazolin-3-one, or sodium borate; 9:1 to 2:3 with N-(3-aminopropyl)-N-dodecyl-1,3-propanediamine; 7:3 to 1:9 with didecyldimethylammonium chloride, or o-phenylphenol; 8:2 to 1:9 with didecylmethylpoly(oxyethyl)ammonium propionate; 1:1 to 1:9 with benzalkonium chloride; 7:3 to 2:8 with the mixture of didecyldimethylammonium carbonate and didecyldimethylammonium bicarbonate; 7:3 to 4:6 with boron oxide; and 7:3 to 1:9 with boric acid.

7. A process for protecting industrial materials against attack and/or destruction by wood-destroying basidiomycetes wherein the wood-destroying basidiomycetes are species of the genera Gloeophyllum, Coniophora, Coriolus, Sternum, or Poria, the process comprising contacting the industrial materials with the composition according to claim 1.

8. The process according to claim 7, wherein the industrial materials are wood, timber products or wood-plastic composites.

9. An industrial material comprising wood and the composition according to claim 1.

Description

EXAMPLES

Synergism Tests

(1) Mycelium pieces were punched out of a colony of the wood-destroying fungus in question and incubated on a malt extract/peptone-containing nutrient agar at 26 C. The growth of the hyphae with and without active compound was compared. The minimum inhibitory concentration (MIC) stated was the concentration at which the radial hyphae growth was suppressed completely.

(2) The synergism was determined using the method described by Kull et al. (F. C. Kull, P. C. Eismann, H. D. Sylvestrowicz, R. L. Mayer, Applied Microbiology 1961, 9, 538-541). The following relationships apply:

(3) $\frac{Q_A}{Q_a}+\frac{Q_B}{Q_b}=\mathrm{SI}$

(4) SI=1 means additivity

(5) SI>1 means antagonism

(6) SI<1 means synergism

(7) Q.sub.a=concentration of substance A which is the MIC

(8) Q.sub.b=concentration of substance B which is the MIC

(9) Q.sub.A=concentration of substance A in the concentration of A/B at which microbial growth is suppressed

(10) Q.sub.B=concentration of substance B in the concentration of A/B at which microbial growth is suppressed

Example 1

Combinations of Penflufen and 3-Iodo-2-propynyl N-butylcarbamate (IPBC) Against the Wood-Destroying Organism Gloeophyllum Trabeum

(11) TABLE-US-00002 MIC against Gloeophyllum trabeum (ppm) SI penflufen 0.3 penflufen:IPBC 9:1 0.3 0.90 penflufen:IPBC 4:1 0.1 0.27 penflufen:IPBC 7:3 0.3 0.71 penflufen:IPBC 3:2 0.1 0.61 penflufen:IPBC 1:1 0.3 0.52 penflufen:IPBC 2:3 0.3 0.42 penflufen:IPBC 3:7 0.3 0.32 penflufen:IPBC 1:4 0.5 0.37 penflufen:IPBC 1:9 0.7 0.30 IPBC 10.0

Example 2

Combinations of Penflufen and 4,5-dichloro-N-octylisothiazolin-3-one (DCOIT) Against the Wood-Destroying Organism Poria placenta

(12) TABLE-US-00003 MIC against Poria placenta (ppm) SI penflufen 0.3 penflufen:DCOIT 9:1 0.1 0.30 penflufen:DCOIT 4:1 0.1 0.27 penflufen:DCOIT 7:3 0.1 0.23 penflufen:DCOIT 3:2 0.1 0.20 penflufen:DCOIT 1:1 0.3 0.51 penflufen:DCOIT 2:3 0.3 0.41 penflufen:DCOIT 3:7 0.3 0.31 penflufen:DCOIT 1:4 0.5 0.35 penflufen:DCOIT 1:9 1.0 0.38 DCOIT 20.0

Example 3

Combinations of Penflufen and N-(3-aminopropyl)-N-dodecyl-1,3-propanediamine (Lonzabac) Against the Wood-Destroying Organism Coriolus versicolor

(13) TABLE-US-00004 MIC against Coriolus versicolor (ppm) SI penflufen 0.5 penflufen:Lonzabac 9:1 0.3 0.54 penflufen:Lonzabac 4:1 0.3 0.48 penflufen:Lonzabac 7:3 0.3 0.42 penflufen:Lonzabac 3:2 0.5 0.60 penflufen:Lonzabac 1:1 0.1 0.10 penflufen:Lonzabac 2:3 0.1 0.08 Lonzabac 30.0

Example 4

Combinations of Penflufen and Didecyldimethylammonium Chloride (DDAC) Against the Wood-Destroying Organisms Coriolus versicolor and Poria placenta

(14) TABLE-US-00005 MIC (ppm) SI Coriolus Poria Coriolus Poria versicolor placenta versicolor placenta penflufen 0.1 0.1 penflufen:DDAC 7:3 0.1 0.1 0.70 0.70 penflufen:DDAC 6:4 0.1 0.1 0.60 0.60 penflufen:DDAC 1:1 0.1 0.1 0.50 0.50 penflufen:DDAC 4:6 0.1 0.1 0.40 0.40 penflufen:DDAC 3:7 0.1 0.1 0.30 0.30 penflufen:DDAC 2:8 0.1 0.1 0.20 0.20 penflufen:DDAC 1:9 0.3 0.3 0.30 0.69 DDAC 60.0 100.0

Example 5

Combinations of penflufen and didecylmethylpoly(oxyethyl)ammonium Propionate (DDA Propionate) Against the Wood-Destroying Organisms Stereum sanguinolentum and Poria placenta

(15) TABLE-US-00006 MIC (ppm) SI Stereum Poria Stereum Poria sanguinolentum placenta sanguinolentum placenta penflufen 3.0 0.3 penflufen:DDA propionate 8:2 0.7 0.1 0.19 0.27 penflufen:DDA propionate 7:3 0.7 0.3 0.17 0.70 penflufen:DDA propionate 6:4 3.0 0.1 0.64 0.20 penflufen:DDA propionate 1:1 3.0 0.1 0.55 0.17 penflufen:DDA propionate 4:6 3.0 0.3 0.46 0.40 penflufen:DDA propionate 3:7 1.0 0.5 0.12 0.50 penflufen:DDA propionate 2:8 3.0 0.7 0.28 0.47 penflufen:DDA propionate 1:9 3.0 0.7 0.19 0.24 DDA propionate 30.0 100.0

Example 6

Combinations of Penflufen and Benzalkonium Chloride Against the Wood-Destroying Organism Poria Placenta

(16) TABLE-US-00007 MIC against Poria placenta (ppm) SI penflufen 0.3 penflufen:benzalkonium chloride 1:1 0.3 0.50 penflufen:benzalkonium chloride 4:6 0.3 0.40 penflufen:benzalkonium chloride 3:7 0.5 0.50 penflufen:benzalkonium chloride 2:8 0.5 0.34 penflufen:benzalkonium chloride 1:9 1.0 0.34 benzalkonium chloride 100.0

Example 7

Combinations of Penflufen and a Mixture of Didecyldimethylammonium Carbonate and Didecyldimethyl Bicarbonate (Carboquat) Against the Wood-Destroying Organisms Stereum sanguinolentum and Poria placenta

(17) TABLE-US-00008 MIC (ppm) SI Stereum Poria Stereum Poria sanguinolentum placenta sanguinolentum placenta penflufen 3.0 0.3 penflufen:Carboquat 7:3 3.0 0.3 0.7 0.7 penflufen:Carboquat 6:4 1.0 0.3 0.2 0.6 penflufen:Carboquat 1:1 3.0 0.3 0.6 0.5 penflufen:Carboquat 4:6 3.0 0.3 0.5 0.4 penflufen:Carboquat 3:7 3.0 0.5 0.4 0.5 penflufen:Carboquat 2:8 3.0 1.0 0.3 0.7 Carboquat 7:3 30.0 30.0

Example 8

Combinations of Penflufen and Boron Oxide (B2O3) Against the Wood-Destroying Organism Coniophora putcana

(18) TABLE-US-00009 MIC against Coniophora puteana (ppm) SI penflufen 0.7 penflufen:boron oxide 7:3 0.3 0.30 penflufen:boron oxide 6:4 0.5 0.43 penflufen:boron oxide 1:1 1.0 0.72 penflufen:boron oxide 4:6 0.7 0.40 boron oxide 100

Example 9

Combinations of Penflufen and Boric Acid Against the Wood-Destroying Organisms Coriolus versicolor and Gloeophyllum trabeum

(19) TABLE-US-00010 MIC (ppm) SI Coriolus Gloeophyllum Coriolus Gloeophyllum versicolor trabeum versicolor trabeum penflufen 0.1 0.3 penflufen:boric acid 7:3 0.1 0.3 0.70 0.70 penflufen:boric acid 6:4 0.1 0.3 0.60 0.60 penflufen:boric acid 1:1 0.1 0.3 0.50 0.50 penflufen:boric acid 4:6 0.1 0.5 0.40 0.67 penflufen:boric acid 3:7 0.1 0.7 0.30 0.70 penflufen:boric acid 2:8 0.1 0.7 0.20 0.47 penflufen:boric acid 1:9 0.3 0.30 boric acid 100.0 100.0

Example 10

Combinations of Penflufen and Sodium Borate Against the Wood-Destroying Organism Poria placenta

(20) TABLE-US-00011 MIC against Poria placenta (ppm) SI penflufen 0.3 penflufen:sodium borate 9:1 0.1 0.30 penflufen:sodium borate 8:2 0.1 0.27 penflufen:sodium borate 7:3 0.1 0.23 penflufen:sodium borate 6:4 0.1 0.20 penflufen:sodium borate 1:1 0.1 0.17 penflufen:sodium borate 4:6 0.1 0.13 penflufen:sodium borate 3:7 0.1 0.10 penflufen:sodium borate 2:8 0.1 0.07 penflufen:sodium borate 1:9 0.5 0.17 sodium borate 100.0

Example 11

Combinations of penflufen and o-phenylphenol Against the Wood-Destroying Organism Gloeophyllum trabeum

(21) TABLE-US-00012 MIC against Gloeophyllum trabeum (ppm) SI penflufen 0.7 penflufen:o-phenylphenol 7:3 0.7 0.70 penflufen:o-phenylphenol 6:4 0.5 0.43 penflufen:o-phenylphenol 1:1 1.0 0.72 penflufen:o-phenylphenol 4:6 0.7 0.41 penflufen:o-phenylphenol 3:7 0.7 0.31 penflufen:o-phenylphenol 2:8 1.0 0.30 penflufen:o-phenylphenol 1:9 3.0 0.47 o-phenylphenol 60.0