Pharmaceutical composition for application to nail

Abstract

Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

Claims

1. A pharmaceutical composition for nail consisting of an antifungal drug, alkylpyrrolidone or a derivative thereof, and a single crosslinking hydrogel, wherein the antifungal drug is one or more selected from the group consisting of lanoconazole, clotrimazole, and bifonazole, and a content of the antifungal drug in the pharmaceutical composition is 1 to 5%, the alkylpyrrolidone is N-methyl-2-pyrrolidone and a content of the alkylpyrrolidone in the pharmaceutical composition is 1 to 20%, the single crosslinking hydrogel consists of 1 to 30% of a water-soluble crosslinking polymer, 1 to 50% of a polyvalent alcohol, 1 to 10% of an adhesion enhancer, 0.1 to 1% of a crosslinking agent, and 20 to 80% of water, and the pharmaceutical composition further comprises one or more ingredients selected from the group consisting of a pH adjusting agent, a thickener, a moisture adjuster, an absorption enhancer, and a surfactant.

2. The pharmaceutical composition for nail according to claim 1, wherein the water-soluble crosslinking polymer is one or more selected from the group consisting of partially neutralized polyacrylate, polyacrylic acid, and carboxymcthyl cellulose sodium, the polyvalent alcohol is one or more selected from the group consisting of glycols such as polyethyleneglycol and propyleneglycol, and glycerin, the adhesion enhancer is one or more selected from the group consisting of polyvinyl alcohol, a carboxyvinyl polymer, and hydroxypropyl cellulose, and the crosslinking agent is one or more selected from the group consisting of salts of a polyvalent aluminum, magnesium, or calcium compound, dried aluminum hydroxide gel, and glycinal.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 A diagram showing a relationship between an elapsed time and an accumulated amount of an antifungal drug permeated into the nail plate.

(2) FIG. 2 One example of a plan view of an adhesive patch for nail of this invention with a cover sheet.

(3) FIG. 3 One example of a sectional view of the adhesive patch for nail of this invention with a cover sheet.

(4) FIG. 4 One example of a plan view of the adhesive patch for nail in the form of a sheet of this invention with a cover sheet.

DESCRIPTION OF REFERENCES AND SIGNS

(5) 1: support

(6) 2: adhesive layer

(7) 3: cover sheet

(8) 4: liner

(9) 5: pharmaceutical composition for nail