NEW PESTICIDAL COMPOUNDS AND USES

Abstract

The invention relates to the use of known and novel phenalkyl carboxamide derivatives of the formula (I)

##STR00001##

wherein the structural elements have the meaning as indicated in the description, for the control of nematodes and/or other helminths, particularly in agriculture and in the animal health field, formulations containing such compounds, particularly agrochemical formulations, and methods for the control of nematodes and helminths. The invention further relates to novel phenalkyl carboxamide derivatives, processes for their preparation, formulations containing such compounds, methods for the control of nematodes and helminths and their use as pest controlling agents, particularly their use as nematicides and their use as anthelmintics against endoparasites in animals and humans.

Claims

1. A compound of formula (I) ##STR00301## wherein n is 0, 1, 2, 3 or 4, limited by the number of available positions in the ring to which a substituent X can be connected, each X is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxy, amino, SH, SF.sub.5, CHO, OCHO, NHCHO, COOH, CONH.sub.2, CONH(OH), OCONH.sub.2, (hydroxyimino)-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, C.sub.2-C.sub.8-alkenyl, C.sub.2-C.sub.8-alkynyl, C.sub.1-C.sub.8-alkylamino, di-(C.sub.1-C.sub.8-alkyl)amino, C.sub.1-C.sub.8-alkoxy, C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms, C.sub.2-C.sub.8-alkenyloxy, C.sub.2-C.sub.8-halogenoalkenyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.8-alkynyloxy, C.sub.3-C.sub.8-halogenoalkynyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.8-cycloalkyl, C.sub.3-C.sub.8-halogenocycloalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylcarbonyl, C.sub.1-C.sub.8-halogenoalkylcarbonyl having 1 to 5 halogen atoms, CONH(C.sub.1-C.sub.8-alkyl), CON(C.sub.1-C.sub.8-alkyl).sub.2, CONH(OC.sub.1-C.sub.8-alkyl), CON(OC.sub.1-C.sub.8-alkyl)(C.sub.1-C.sub.8-alkyl), C.sub.1-C.sub.8-alkoxycarbonyl, C.sub.1-C.sub.8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylcarbonyloxy, C.sub.1-C.sub.8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkyl carbonyl amino, C.sub.1-C.sub.8-halogenoalkylcarbonylamino having 1 to 5 halogen atoms, OCONH(C.sub.1-C.sub.8-alkyl), OCON(C.sub.1-C.sub.8-alkyl).sub.2, OCONH(OC.sub.1-C.sub.8-alkyl), OCO(OC.sub.1-C.sub.8-alkyl), SC.sub.1-C.sub.8-alkyl, SC.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.8-alkyl, S(O)C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, S(O).sub.2C.sub.1-C.sub.8-alkyl, S(O).sub.2C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, (C.sub.1-C.sub.6-alkoxyimino)-C.sub.1-C.sub.6-alkyl, (C.sub.2-C.sub.6-alkenyloxyimino)-C.sub.1-C.sub.6-alkyl, (C.sub.3-C.sub.6-alkynyloxyimino)-C.sub.1-C.sub.6-alkyl, (benzyloxyimino)-C.sub.1-C.sub.6-alkyl, benzyloxy, S-benzyl, benzylamino, phenoxy, S-phenyl and phenylamino, Q represents an aromatic or partially saturated or saturated, 5- or 6-membered heterocyclic ring containing one to four heteroatoms chosen from N, S, and O bearing the substituent Ym with m is 0, 1, 2, 3 or 4, limited by the number of available positions in Q to which a substituent Y can be connected, and each Y is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxy, amino, SH, SF.sub.5, CHO, OCHO, NHCHO, COOH, CONH.sub.2, CONH(OH), OCONH.sub.2, (hydroxyimino)-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, C.sub.2-C.sub.8-alkenyl, C.sub.2-C.sub.8-alkynyl, C.sub.1-C.sub.8-alkylamino, di-(C.sub.1-C.sub.8-alkyl)amino, C.sub.1-C.sub.8-alkoxy, C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms C.sub.2-C.sub.8-alkenyloxy, C.sub.2-C.sub.8-halogenoalkenyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.8-alkynyloxy, C.sub.3-C.sub.8-halogenoalkynyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.8-cycloalkyl, C.sub.3-C.sub.8-halogenocycloalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylcarbonyl, C.sub.1-C.sub.8-halogenoalkylcarbonyl having 1 to 5 halogen atoms, CONH(C.sub.1-C.sub.8-alkyl), CON(C.sub.1-C.sub.8-alkyl).sub.2, CONH(OC.sub.1-C.sub.8-alkyl), CON(OC.sub.1-C.sub.8-alkyl)(C.sub.1-C.sub.8-alkyl), NH(C.sub.1-C.sub.8-alkylcarbonyl), C.sub.1-C.sub.8-alkoxycarbonyl, C.sub.1-C.sub.8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylcarbonyloxy, C.sub.1-C.sub.8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylcarbonylamino, C.sub.1-C.sub.8-halogenoalkylcarbonylamino having 1 to 5 halogen atoms, OCONH(C.sub.1-C.sub.8-alkyl), OCON(C.sub.1-C.sub.8-alkyl).sub.2, OCONH(OC.sub.1-C.sub.8-alkyl), OCO(OC.sub.1-C.sub.8-alkyl), SC.sub.1-C.sub.8-alkyl, SC.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.8-alkyl, S(O)C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, S(O).sub.2C.sub.1-C.sub.8-alkyl, S(O).sub.2C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, CH.sub.2SC.sub.1-C.sub.8-alkyl, CH.sub.2S(O)C.sub.1-C.sub.8-alkyl, CH.sub.2S(O).sub.2C.sub.1-C.sub.8-alkyl, (C.sub.1-C.sub.6-alkoxyimino)-C.sub.1-C.sub.6-alkyl, (C.sub.2-C.sub.6-alkenyloxyimino)-C.sub.1-C.sub.6-alkyl, (C.sub.3-C.sub.6-alkynyloxyimino)-C.sub.1-C.sub.6-alkyl, (benzyloxyimino)-C.sub.1-C.sub.6-alkyl, benzyloxy, S-benzyl, benzylamino, phenoxy, S-phenyl and phenylamino, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and are selected from the group consisting of hydrogen, halogen, cyano, hydroxy, amino, SH, CHO, OCHO, NHCHO, COOH, CONH.sub.2, CONH(OH), OCONH.sub.2, a (hydroxyimino)-C.sub.1-C.sub.6-alkyl group, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.1-C.sub.6-alkylamino, di-(C.sub.1-C.sub.6-alkyl)amino, C.sub.1-C.sub.6-alkoxy, hydroxy-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.3-alkyl, C.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.6-halogenoalkoxy having 1 to 5 halogen atoms, C.sub.2-C.sub.6-alkenyloxy, C.sub.2-C.sub.6-halogenoalkenyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.6-alkynyloxy, C.sub.3-C.sub.6-halogenoalkynyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halogenocycloalkyl having 1 to 5 halogen atoms, C.sub.3-C.sub.6-cycloalkyl-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-halogenocycloalkyl-C.sub.1-C.sub.6-alkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.6-alkylcarbonyl, C.sub.1-C.sub.6-halogenoalkylcarbonyl having 1 to 5 halogen atoms, CONH(C.sub.1-C.sub.6-alkyl), CON(C.sub.1-C.sub.6-alkyl).sub.2, CONH(OC.sub.1-C.sub.6-alkyl), CON(OC.sub.1-C.sub.6-alkyl)(C.sub.1-C.sub.6-alkyl), C.sub.1-C.sub.6-alkoxycarbonyl, a C.sub.1-C.sub.6-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, OC(O)C.sub.1-C.sub.6-alkyl, OC(O)C.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, NHC(O)C.sub.1-C.sub.6-alkyl, NHC(O)C.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, OCONH(C.sub.1-C.sub.6-alkyl), OCON(C.sub.1-C.sub.6-alkyl).sub.2, OCONH(OC.sub.1-C.sub.6-alkyl), OCO(OC.sub.1-C.sub.6-alkyl), SC.sub.1-C.sub.6-alkyl, SC.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.6-alkyl, S(O)C.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, S(O).sub.2C.sub.1-C.sub.6-alkyl, S(O).sub.2C.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, benzyl, benzyloxy, S-benzyl, S(O)-benzyl, S(O).sub.2-benzyl, benzyl amino, phenoxy, S-phenyl, S(O)-phenyl, S(O).sub.2-phenyl, phenylamino, phenylcarbonylamino, 2,6-dichlorophenyl-carbonylamino, 2-chlorophenyl-carbonylamino and phenyl, with the proviso that R.sup.1 is fluorine and/or R.sup.2 is fluorine, R.sup.5 is selected from the group consisting of hydrogen, cyano, CHO, OH, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-halogenoalkoxy having 1 to 5 halogen atoms, C.sub.3-C.sub.7-cycloalkyl, C.sub.3-C.sub.7-halogenocycloalkyl having 1 to 5 halogen atoms, C.sub.3-C.sub.7-cycloalkyl-C.sub.1-C.sub.6-alkyl, CONH(C.sub.1-C.sub.6-alkyl), C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.7-cycloalkyl-C.sub.1-C.sub.6-alkyl, cyano-C.sub.1-C.sub.6-alkyl, amino-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkylamino-C.sub.1-C.sub.6-alkyl, di-(C.sub.1-C.sub.6-alkyl)amino-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkylcarbonyl, C.sub.1-C.sub.6-halogenoalkylcarbonyl having 1 to 5 halogen atoms, C.sub.1-C.sub.6-alkoxycarbonyl, C.sub.1-C.sub.6-benzyloxycarbonyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkylcarbonyl, SC.sub.1-C.sub.6-alkyl, SC.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, S(O).sub.2C.sub.1-C.sub.6-alkyl, and S(O).sub.2C.sub.1-C.sub.6-halogenoalkyl having 1 to 5 halogen atoms, A represents a phenyl group of the formula (A1) ##STR00302## wherein o is 0, 1, 2, 3, 4 or 5, and each R is independently selected from the group consisting of halogen, nitro, OH, NH.sub.2, SH, SF.sub.5, CHO, OCHO, NHCHO, COOH, cyano, C.sub.1-C.sub.8-alkyl, C.sub.1-C.sub.8-halogenoalkyl having 1 to 9 halogen atoms, C.sub.2-C.sub.8-alkenyl, C.sub.2-C.sub.8-alkynyl, C.sub.3-C.sub.6-cycloalkyl, SC.sub.1-C.sub.8-alkyl, SC.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkoxy, C.sub.1-C.sub.8-halogenoalkoxy having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkoxy-C.sub.2-C.sub.8-alkenyl, C.sub.1-C.sub.8-alkoxycarbonyl, C.sub.1-C.sub.8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylcarbonyloxy, C.sub.1-C.sub.8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.8-alkyl, S(O)C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, S(O).sub.2C.sub.1-C.sub.8-alkyl, S(O).sub.2C.sub.1-C.sub.8-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.8-alkylsulfonamide, NH(C.sub.1-C.sub.8-alkyl), N(C.sub.1-C.sub.8-alkyl).sub.2, phenyl (optionally substituted by C.sub.1-C.sub.6-alkoxy) and phenoxy, or two R bonded to adjacent carbon atoms together represent O(CH.sub.2).sub.pO, wherein p represents 1 or 2, or A represents a heterocycle of the formula (Het-1) ##STR00303## in which R.sup.6 and R.sup.7 may be the same or different and are selected from the group consisting of hydrogen, halogen, amino, nitro, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.8 is selected from the group consisting of hydrogen, halogen, nitro, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-2) ##STR00304## in which R.sup.9 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.10 and R.sup.11 may be the same or different and are selected from the group consisting of hydrogen, halogen, amino, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-31 ##STR00305## in which R.sup.12 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.13 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-4) ##STR00306## in which R.sup.14 and R.sup.15 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, SC.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl) and pyridyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), and R.sup.16 is selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-5) ##STR00307## in which R.sup.17 and R.sup.18 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyloxy and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.19 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 atoms, or A represents a heterocycle of the formula (Het-6) ##STR00308## in which R.sup.20 is selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.21 and R.sup.23 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalky having 1 to 5 halogen atoms, and R.sup.22 is selected from the group consisting of hydrogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl, hydroxyl-C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, S(O).sub.2N(C.sub.1-C.sub.4-alkyl).sub.2, C.sub.1-C.sub.6-alkylcarbonyl, S(O).sub.2-phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl) and benzoyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-7) ##STR00309## in which R.sup.24 is selected from the group consisting of hydrogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl, hydroxy-C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, S(O).sub.2N(C.sub.1-C.sub.4-alkyl).sub.2, C.sub.1-C.sub.6-alkylcarbonyl, S(O).sub.2-phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl) and benzoyl (optionally substituted by halogen or a C.sub.1-C.sub.4-alkyl), and R.sup.25, R.sup.26 and R.sup.27 may be the same or different and are selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenalkyl having 1 to 5 halogen atoms and C.sub.1-C.sub.4-alkylcarbonyl, or A represents a heterocycle of the formula (Het-8) ##STR00310## in which R.sup.28 is selected from the group consisting of hydrogen and C.sub.1-C.sub.4-alkyl, and R.sup.29 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-9) ##STR00311## in which R.sup.30 is selected from the group consisting of hydrogen and C.sub.1-C.sub.4-alkyl, and R.sup.31 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-10) ##STR00312## in which R.sup.32 is selected from the group consisting of hydrogen, halogen, amino, cyano, C.sub.1-C.sub.4-alkylamino, di-(C.sub.1-C.sub.4-alkyl)amino, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), and R.sup.33 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.5-halogenoalkoxy having 1 to 9 halogen atoms, amino, substituted or unsubstituted C.sub.1-C.sub.5-alkylamino or substituted or unsubstituted di-(C.sub.1-C.sub.5-alkyl)-amino, or A represents a heterocycle of the formula (Het-11) ##STR00313## in which R.sup.34 is selected from the group consisting of hydrogen, halogen, amino, cyano, C.sub.1-C.sub.4-alkylamino, di-(C.sub.1-C.sub.4-alkyl)amino, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.35 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-12) ##STR00314## in which R.sup.36 is selected from the group consisting of hydrogen, halogen, cyano, nitro, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, SC.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, aminocarbonyl and aminocarbonyl-C.sub.1-C.sub.4-alkyl, and R.sup.37 is selected from the group consisting of hydrogen, halogen, cyano, nitro, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-alkyl, and S(O).sub.2C.sub.1-C.sub.4-alkyl, and R.sup.38 is selected from the group consisting of hydrogen, phenyl, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, hydroxy-C.sub.1-C.sub.4-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkylthio-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyl-S(O)C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyl-S(O).sub.2C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkylthio-C.sub.1-C.sub.4-alkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkoxy-C.sub.1-C.sub.4-alkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-13) ##STR00315## in which R.sup.39 is selected from the group consisting of hydrogen, halogen, cyano, nitro, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, SC.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 atoms, aminocarbonyl and aminocarbonyl-C.sub.1-C.sub.4-alkyl, and R.sup.40 is selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, SC.sub.1-C.sub.4-alkylS(O)C.sub.1-C.sub.4-alkyl, and S(O).sub.2C.sub.1-C.sub.4-alkyl, and R.sup.41 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, hydroxy-C.sub.1-C.sub.4-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkylthio-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyl-S(O)C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyl-S(O).sub.2C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkylthio-C.sub.1-C.sub.4-alkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkoxy-C.sub.1-C.sub.4-alkyl having 1 to 5 halogen atoms and phenyl (optionally substituted by halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl or nitro), or A represents a heterocycle of the formula (Het-14) ##STR00316## in which R.sup.42 is selected from the group consisting of hydrogen, halogen, cyano, nitro, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, SC.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, aminocarbonyl and aminocarbonyl-C.sub.1-C.sub.4-alkyl, and R.sup.43 is selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.44 is selected from the group consisting of hydrogen, phenyl, benzyl, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, hydroxy-C.sub.1-C.sub.4-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkylthio-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyl-S(O)C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyl-S(O).sub.2C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkylthio-C.sub.1-C.sub.4-alkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkoxy-C.sub.1-C.sub.4-alkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-15) ##STR00317## in which R.sup.45 and R.sup.46 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-16) ##STR00318## in which R.sup.47 and R.sup.48 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, phenyl (optionally substituted by halogen or a C.sub.1-C.sub.4-alkyl), and heterocyclyl like pyridyl, pyrimidinyl and thiadiazolyl (each optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-17) ##STR00319## in which R.sup.49 and R.sup.50 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-18) ##STR00320## in which R.sup.51 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-19) ##STR00321## in which R.sup.52 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.53 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-20) ##STR00322## in which R.sup.54 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-21) ##STR00323## in which R.sup.55 is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, with the proviso that for Het-21, R.sup.55 is not CF.sub.3, and R.sup.56, R.sup.57 and R.sup.58, which may be the same or different, are selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.4-alkyl and S(O).sub.2C.sub.1-C.sub.4-alkyl, or A represents a heterocycle of the formula (Het-22) ##STR00324## in which R.sup.59 is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4 alkoxy, SC.sub.1-C.sub.5-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, SC.sub.2-C.sub.5-alkenyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, phenyloxy (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl) and S-phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), and R.sup.60, R.sup.61 and R.sup.62, which may the same or different, are selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, N-morpholine optionally substituted by halogen or C.sub.1-C.sub.4-alkyl, and thienyl (optionally substituted by halogen or a C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-23) ##STR00325## in which R.sup.63, R.sup.64, R.sup.65 and R.sup.66, which may be the same or different, are selected from the group consisting of hydrogen, halogen, hydroxy, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.4-alkyl and S(O).sub.2C.sub.1-C.sub.4-alkyl, or A represents a heterocycle of the formula (Het-24) ##STR00326## in which R.sup.67 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.68 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.6-alkoxycarbonyl, benzyl (optionally substituted by 1 to 3 halogen atoms), benzyloxycarbonyl (optionally substituted by 1 to 3 halogen atoms), and heterocyclyl like pyridyl and pyrimidinyl (each optionally substituted by halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms), or A represents a heterocycle of the formula (Het-25) ##STR00327## in which R.sup.69 is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, and R.sup.70 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and benzyl, or A represents a heterocycle of the formula (Het-26) ##STR00328## in which X.sup.1 is selected from the group consisting of sulphur, SO, SO.sub.2 and CH.sub.2, and R.sup.71 is selected from the group consisting of C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.72 and R.sup.73 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1-C.sub.4-alkyl, or A represents a heterocycle of the formula (Het-27) ##STR00329## in which R.sup.74 is selected from the group consisting of C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-28) ##STR00330## in which R.sup.75 is selected from the group consisting of C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-29) ##STR00331## in which R.sup.76 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, for controlling nematodes and/or other helminths.

2. The compound of claim 1, wherein X, n, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A have the meanings as defined in claim 1; Q represents an optionally mono- or polysubstituted heteroaromatic ring from the group consisting of Q-1 to Q-64: ##STR00332## ##STR00333## ##STR00334## with m is 0, 1 or 2, limited by the number of available positions in Q to which a substituent Y can be connected, and each Y is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.2-C.sub.4-alkenyl, C.sub.2-C.sub.4-alkynyl, C.sub.1-C.sub.4-alkylamino, di-(C.sub.1-C.sub.4-alkyl)amino, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, C.sub.2-C.sub.4-alkenyloxy, C.sub.2-C.sub.4-halogenoalkenyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.4-alkynyloxy, C.sub.3-C.sub.4-halogenoalkynyloxy having 1 to 5 halogen atoms, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halogenocycloalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkylcarbonyl, C.sub.1-C.sub.4-halogenoalkylcarbonyl having 1 to 5 halogen atoms, CONH(C.sub.1-C.sub.4-alkyl), CON(C.sub.1-C.sub.4-alkyl).sub.2, CONH(OC.sub.1-C.sub.4-alkyl), CON(OC.sub.1-C.sub.4-alkyl)(C.sub.1-C.sub.4-alkyl), NH(C.sub.1-C.sub.4-alkylcarbonyl), C.sub.1-C.sub.4-alkoxycarbonyl, C.sub.1-C.sub.4-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkylcarbonyloxy, C.sub.1-C.sub.4-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkylcarbonylamino, C.sub.1-C.sub.4-halogenoalkylcarbonylamino having 1 to 5 halogen atoms, OCONH(C.sub.1-C.sub.4-alkyl), OCON(C.sub.1-C.sub.4-alkyl).sub.2, OCONH(OC.sub.1-C.sub.4-alkyl), OCO(OC.sub.1-C.sub.4-alkyl), SC.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, S(O).sub.2C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, CH.sub.2SC.sub.1-C.sub.4-alkyl, CH.sub.2S(O)C.sub.1-C.sub.4-alkyl, CH.sub.2S(O).sub.2C.sub.1-C.sub.4-alkyl, (C.sub.1-C.sub.4-alkoxyimino)-C.sub.1-C.sub.4-alkyl, (C.sub.2-C.sub.6-alkenyl oxyimino)-C.sub.1-C.sub.4-alkyl, (C.sub.3-C.sub.6-alkynyloxyimino)-C.sub.1-C.sub.4-alkyl, (benzyloxyimino)-C.sub.1-C.sub.6-alkyl, benzyloxy, S-benzyl, benzylamino, phenoxy, S-phenyl and phenylamino.

3. The compound of claim 1, wherein n is 1 or 2, each X is selected from the group consisting of hydrogen, halogen, nitro, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, Q represents an optionally mono- or polysubstituted heteroaromatic ring from the group consisting of Q-4, Q-11, Q-21, Q-22, Q-25, Q-36, Q-37, Q-38, Q-40, Q-41, Q-42, Q-45, Q-53, Q-58, Q-62, Q-63 and Q-64, with m is 0, 1 or 2, limited by the number of available positions in Q to which a substituent Y can be connected, and each Y is independently selected from the group consisting of hydrogen, CF.sub.3, CH.sub.2CF.sub.3, methyl, ethyl, fluorine, chlorine, bromine, iodine, cyano, OCH.sub.3, OCH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, OCH.sub.2CF.sub.3, S(O).sub.2CH.sub.3, NHC(O)CH.sub.3, NHCH.sub.3 and N(CH.sub.3).sub.2, R.sup.1 and R.sup.2 are the same or different and are selected from the group consisting of hydrogen, halogen, cyano, hydroxy, C.sub.1-C.sub.4-alkyl, C.sub.2-C.sub.4-alkenyl, C.sub.2-C.sub.4-alkynyl, C.sub.1-C.sub.4-alkoxy, C.sub.3-C.sub.6-cycloalkyl-C.sub.1-C.sub.3-alkyl, C.sub.1-C.sub.4-alkoxycarbonyl, OC(O)C.sub.1-C.sub.4-alkyl, NHC(O)C.sub.1-C.sub.4-alkyl, and phenyl, with the proviso that R.sup.1 is fluorine and/or R.sup.2 is fluorine, R.sup.3 and R.sup.4 are the same or different and are selected from the group consisting of hydrogen, COOH, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl C.sub.1-C.sub.4-alkoxy, hydroxy-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.3-alkyl, CONH(C.sub.1-C.sub.4-alkyl), C.sub.1-C.sub.4-alkoxycarbonyl, OC(O)C.sub.1-C.sub.4-alkyl, and phenyl, R.sup.5 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4-alkyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkylcarbonyl, C.sub.1-C.sub.4-alkoxycarbonyl, A represents a phenyl group of formula (A1) ##STR00335## wherein o is 0, 1 or 2, and each R is independently selected from the group consisting of halogen, nitro, OH, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.3-C.sub.6-cycloalkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1C.sub.1-C.sub.4-alkoxycarbonyl, NH(C.sub.1-C.sub.4-alkyl), phenyl (optionally substituted by C.sub.1-C.sub.4-alkoxy) and phenoxy, or A represents a heterocycle of the formula (Het-1) ##STR00336## in which R.sup.6 and R.sup.7 may be the same or different and are selected from the group consisting of hydrogen, halogen, nitro, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.8 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-2) ##STR00337## in which R.sup.9 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.10 and R.sup.11 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, phenyl optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-4) ##STR00338## in which R.sup.14 and R.sup.15 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, SC.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl) and pyridyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), and R.sup.16 is selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, or A represents a heterocycle of the formula (Het-5) ##STR00339## in which R.sup.17 and R.sup.18 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkyloxy and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.19 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 atoms, or A represents a heterocycle of the formula (Het-6) ##STR00340## in which R.sup.20 is selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, and R.sup.21 and R.sup.23 may be the same or different and are selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalky having 1 to 5 halogen atoms, and R.sup.22 is selected from the group consisting of hydrogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy-C.sub.1-C.sub.4-alkyl, or A represents a heterocycle of the formula (Het-10) ##STR00341## in which R.sup.32 is selected from the group consisting of hydrogen, halogen, amino, cyano, C.sub.1-C.sub.4-alkylamino, di-(C.sub.1-C.sub.4-alkyl)amino, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), and R.sup.33 is selected from the group consisting of halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.5-halogenoalkoxy comprising 1 to 9 halogen atoms, amino, substituted or unsubstituted C.sub.1-C.sub.5-alkylamino or substituted or unsubstituted di-(C.sub.1-C.sub.5-alkyl)-amino, or A represents a heterocycle of the formula (Het-21) ##STR00342## in which R.sup.55 is selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms and C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, with the proviso that for Het-21, R.sup.55 is not CF.sub.3, and R.sup.56, R.sup.57 and R.sup.58, which may be the same or different, are selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.4-alkyl and S(O).sub.2C.sub.1-C.sub.4-alkyl, or A represents a heterocycle of the formula (Het-22) ##STR00343## in which R.sup.59 is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4 alkoxy, SC.sub.1-C.sub.5-alkyl, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, SC.sub.2-C.sub.5-alkenyl, SC.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, phenyloxy (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl) and S-phenyl (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl), and R.sup.60, R.sup.61 and R.sup.62, which may the same or different, are selected from the group consisting of hydrogen, halogen, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, SC.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, S(O)C.sub.1-C.sub.4-alkyl, S(O).sub.2C.sub.1-C.sub.4-alkyl, N-morpholine (optionally substituted by halogen or C.sub.1-C.sub.4-alkyl) and thienyl (optionally substituted by halogen or a C.sub.1-C.sub.4-alkyl), or A represents a heterocycle of the formula (Het-29) ##STR00344## in which R.sup.76 is selected from the group consisting of hydrogen, halogen, C.sub.1-C.sub.4-alkyl and C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms.

4. The compound of claim 1, wherein n is 1 or 2, each X is selected from the group consisting of hydrogen, halogen, nitro, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-halogenoalkyl having 1 to 5 halogen atoms, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-halogenoalkoxy having 1 to 5 halogen atoms, Q is selected from: ##STR00345## ##STR00346## R.sup.1 and R.sup.2 are the same or different and are selected from the group consisting of hydrogen, methyl, ethyl, methoxy, ethoxy or fluorine, with the proviso that R.sup.1 is fluorine and/or R.sup.2 is fluorine, R.sup.3 and R.sup.4 are the same or different and are selected from the group consisting of hydrogen, methyl or ethyl, R.sup.5 is hydrogen, and A is selected from: ##STR00347## or A is selected from: ##STR00348##

5. A method of protecting crops comprising administering an effective amount of the compound of claim 1.

6. A method of protecting animals comprising administering an effective amount of the compound of claim 1.

7. A compound of formula (Ia) ##STR00349## wherein n, X, Q, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined in claim 1, and R.sup.1a is fluorine.

8. A compound of formula (Ib) ##STR00350## wherein n, X, Q, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and A are as defined in claim 1, and R.sup.2a is fluorine.

9. A compound of formula (Ic) ##STR00351## wherein n, X, Q, R.sup.3, R.sup.4, R.sup.5 and A are as defined in claim 1, and both R.sup.1a and R.sup.2a are fluorine.

10. An agrochemical formulation, comprising the compound of claim 1.

11. An agrochemical formulation comprising the compound of claim 7.

12. The agrochemical formulation of claim 10, further comprising at least one extender and/or at least one surfactant.

13. The agrochemical formulation of claim 10, wherein the compound of the formula (I), (Ia), (Ib) or (Ic) is present in a mixture with at least one other active compound.

14. A method for controlling an animal pest, comprising applying an effective amount of the compound of formula (I) as defined in claim 1 to an animal pest and/or a habitat of the animal pest.

15. The method of claim 14, wherein the animal pest comprises a nematode or is a nematode.

16. A method for protecting a seed and/or a germinating plant from attack by a pest comprising the step of contacting the seed with a compound of formula (I) as defined in claim 1.

17. A seed obtained by the method of claim 16.

18. A method for controlling an animal pest comprising administering an effective amount of the compound of claim 7.

19. The method of claim 18, wherein the animal pest comprises a nematode or is a nematode.

20. A method of protecting crops or animals comprising administering an effective amount of the compound of claim 7.

21. A compound of formula (INT) ##STR00352## wherein R.sup.1, R.sup.2, Q, X and n are as defined in claim 1.

Description

PREPARATION EXAMPLES

.SUP.1.H-NMR Data

[0706] Method M1: .sup.1H-NMR-data were determined with a Bruker Avance 400 equipped with a flow cell (60 l volume) or with a Bruker AVIII 400 equipped with 1.7 mm cryo CPTCI probe head or with a Bruker AVII 600 (600.13 MHz) equipped with a 5 mm cryo TCI probe head or with a Bruker AVIII 600 (601.6 MHz) equipped with a 5 mm cryo CPMNP probe head with tetramethylsilane as reference (0.0) and the solvents CD.sub.3CN, CDCl.sub.3 or D.sub.6-DMSO.

[0707] Method M2: Alternatively .sup.1H-NMR-data were determined with a Bruker DMX300 (.sup.1H-NMR: 300 MHz) using tetramethylsilane as reference standard.

[0708] NMR-data of selected examples are listed in classic format (chemical shift 6, multiplicity, number of hydrogen atoms) or as NMR-peak-lists.

Preparation Example 1

Synthesis of N-{2-[2-chloro-4-(5-chloropyridin-3-yl)phenyl]ethyl}-2-(trifluoromethyl)benzamide (corresponds to product expl. 1-45)

Step 1: Synthesis of N-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(trifluoromethyl)benzamide

[0709] ##STR00104##

[0710] 5.6 g (55.3 mmol) of triethylamine were added to a solution of 6 g (22.1 mmol) of 2-(4-bromo-2-chlorophenyl)ethanamine hydrochlorid in 25 mL dichloromethane at room temperature. 4.6 g (22.1 mmol) of 2-(trifluoromethyl)benzoyl chloride in 25 mL dichloromethane were slowly added to the reaction mixture at room temperature. After completion of reaction, the reaction mixture was diluted with dichloromethane and washed with water. The combined organic layers were evaporated under reduced pressure to yield 9.07 g (quantitative yield). The product has been used in step 2 without prior purification.

[0711] LCMS (M+H): 405.8, 407.8

[0712] .sup.1H-NMR (400 MHz, d.sub.6-DMSO, Method M1); 8.61 (t, 1H, NH), 7.77-7.62 (m, 3H), 7.53-7.51 (dd, 1H), 7.46 (d, 1H), 7.35 (d, 1H), 3.50-3.45 (qu, 2H), 2.91 (t, 2H).

Step 2: Synthesis of N-{2-[2-chloro-4-(5-chloropyridin-3-yl)phenyl]ethyl}-2-(trifluoromethyl)benzamide (corresponds to product expl. 1-45)

[0713] ##STR00105##

[0714] 110.9 mg (0.27 mmol) of N-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(trifluoromethyl)benzamide (from step 1) and 47.2 mg (0.30 mmol) of (5-chloropyridin-3-yl)boronic acid were dissolved in 3 mL dioxane. Thereafter, 22 mg (0.03 mmol) of 1,1-bis-(diphenylphosphino)-ferrocen)-palladium-dichloromethane complex and 286.2 mg (2.7 mmol) of sodium carbonate in 2 mL water were added and treated in a sealed microwave vial in a Biotage microwave oven (Initiator) at 100 C. for 20 minutes. The reaction mixture was filtered over a silica gel sodium sulfate cartridge, the solvents were evaporated and the crude product was purified by preparative HPLC to afford 60.6 mg (46%) of the title compound as off-white solid.

[0715] .sup.1H-NMR (400 MHz, d6-DMSO, Method M1); 8.91 (s, 1H), 8.68 (t, 1H, NH), 8.64 (s, 1H), 8.33 (s, 1H), 7.94 (s, 1H), 7.83-7.46 (m, 6H), 3.55-3.50 (qu, 2H), 3.00 (t, 2H).

Preparation Example 2

Synthesis of N-[2-[2-chloro-4-[4-(trifluoromethyl)pyrazol-1-yl]phenyl]-2,2-difluoro-ethyl]-2-(trifluoromethyl)benzamide (corresponds to product expl. 1-69)

Step 1: Synthesis of 2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethanamine

[0716] ##STR00106##

[0717] Synthesis of 2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethanamine was performed in analogy to WO 2013/064460 A1 (referred as intermediates IIa-14 and IIa-15).

[0718] .sup.1H-NMR (400 MHz, d6-DMSO, Method M1); 7.91 (s, 1H), 7.74 (d, 1H), 7.57 (d, 1H), 4.68 (bs, 2H, NH.sub.2), 3.46 (t, 2H).

Step 2: Synthesis of N-[2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethyl]-2-(trifluoromethyl)benzamide

[0719] ##STR00107##

[0720] 1.395 g (13.7 mmol) of triethylamine were added to a solution of 1.49 g (5.51 mmol) of 2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethanamine (from step 1) in 30 mL dichloromethane at room temperature. 1.15 g (5.51 mmol) of 2-(trifluoromethyl)benzoyl chloride in 10 mL dichloromethane were slowly added to the reaction mixture at room temperature. After completion of reaction, the reaction mixture was diluted with dichloromethane and washed with water. The combined organic layers were evaporated under reduced pressure. The remaining residue was purified by flash silica gel chromatography resulting in 1.08 gas white solid (yield: 43.8%).

[0721] .sup.1H-NMR (400 MHz, d6-DMSO, Method M1); 8.98 (t, 1H, NH), 7.91 (s, 1H), 7.77-7.56 (m, 5H), 7.36 (d, 1H), 4.17 (dt, 2H).

Step 3: Synthesis of N-[2-[2-chloro-4-[4-(trifluoromethyl)pyrazol-1-yl]phenyl]-2,2-difluoro-ethyl]-2-(trifluoromethyl)benzamide (corresponds to product expl. 1-69)

[0722] ##STR00108##

[0723] 149.7 mg (0.33 mmol) of N-[2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethyl]-2-(trifluoromethyl) benzamide (from step 3) were dissolved in 4.4 mL acetonitrile. Subsequently, 55.2 mg (0.4 mmol) of 4-trifluoropyrazole, 4.8 mg (0.03 mmol) of copper(I) oxide, 9.3 mg (0.06 mmol) of salicylaldoxime and 165.3 mg (0.5 mmol) of cesium carbonate were added at room temperature. The reaction mixture was kept and stirred in a sealed vial at 100 C. for 18 hours. The reaction mixture was allowed to cool to ambient temperature and was diluted with ethyl acetate followed by filtration. The filtrate was evaporated under reduced pressure and the remaining residue was purified by flash silica gel chromatography resulting in 39 mg as white solid (yield: 21.3%).

[0724] .sup.1H-NMR (400 MHz, d6-DMSO, Method M1); 9.38 (s, 1H), 9.03 (t, 1H, NH), 8.31 (s, 1H), 8.20 (d, 1H), 8.06 (dd, 1H), 7.83-7.49 (m, 4H), 7.39 (d, 1H), 4.22 (dt, 2H).

Preparation Example 3

Synthesis of N-[2-[2-chloro-4-(6-fluoro-3-pyridyl)phenyl]-2,2-difluoro-ethyl]-2-(trifluoromethyl)benzamide (corresponds to product expl. 1-93)

[0725] ##STR00109##

[0726] 138.7 mg (0.31 mmol) N N-[2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethyl]-2-(trifluoromethyl) benzamide (from preparation example 2, step 2) and 44.2 mg (0.31 mmol) (6-fluoro-3-pyridyl)boronic acid were dissolved in 5 mL dioxane. Thereafter, 23.1 mg (0.03 mmol) dichloro-bis(tricyclohexylphosphine) palladium(II) and 204.2 mg (0.63 mmol) cesium carbonate in 0.61 mL water were added and treated in a sealed microwave vial in a Biotage microwave oven (Initiator) at 100 C. for 30 minutes. The reaction mixture was filtered over a silica gel sodium sulfate cartridge, the solvents were evaporated and the crude product was purified by preparative HPLC to afford 120 mg (84.3%) of the title compound as off-white solid.

[0727] .sup.1H-NMR (400 MHz, d6-DMSO, Method M1); 9.03 (t, 1H, NH), 8.67 (s, 1H), 8.42-8.38 (dt, 1H), 8.02 (s, 1H), 7.88 (d, 1H), 7.77-7.62 (m, 4H), 7.39-7.32 (d+d, 2H), 4.26-4.18 (dt, 1H).

Preparation Example 4

Synthesis of N-{2-[2-chloro-4-(6-chloropyridin-3-yl)phenyl]-2-fluoroethyl}-2-(trifluoromethyl) benzamide (corresponds to product expl. 1-73)

Step 1: Synthesis of 2-(4-bromo-2-chlorophenyl)-2-trimethylsilyloxyacetonitrile

[0728] ##STR00110##

[0729] To vacuum dried potassium cyanide (22.2 g, 342 mmol) in acetonitrile (150 mL), 4-bromo-2-chlorobenzaldehyde (25 g, 114 mmol) and zinc iodide were added. Then trimethylsilylchloride (20 g, 182 mmol) was added dropwise and the mixture was refluxed for 40 hours. The reaction mixture was filtered and concentrated in vacuo to afford the title compound as a brown oil which was used in the next step without additional purification.

Step 2: Synthesis of 2-(4-bromo-2-chlorophenyl)-2-fluoroacetonitrile

[0730] ##STR00111##

[0731] To a solution of 2-(4-bromo-2-chlorophenyl)-2-trimethylsilyloxyacetonitrile (36.3 g, 114 mmol) in dichloromethane (150 mL), DAST (22.2 g, 125 mmol) was added dropwise maintaining the temperature between 3 and 0 C. Then the reaction mixture was allowed to warm to room temperature and stirred over weekend. The reaction mixture was quenched with a saturated aqueous solution of sodium bicarbonate solution. The phases were separated. The organic layer was washed with a saturated sodium bicarbonate solution and some water. The organic layer was dried with sodium sulfate. The solvent was removed in vacuo to afford the title compound as a yellow oil which was used in the next step without additional purification.

Step 3: Synthesis of 2-(4-bromo-2-chlorophenyl)-2-fluoroethylamine hydrochloride

[0732] ##STR00112##

[0733] To a solution of 2-(4-bromo-2-chlorophenyl)-2-fluoroacetonitrile (27.7 g, 111 mmol) in tetrahydrofurane (300 mL), diborane in tetrahydrofurane (444 mmol) was added dropwise maintaining the temperature between 10 C. and 5 C. The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was quenched with methanol (100 mL), acidified with a dry solution of HO/ether and evaporated to dryness. Recrystallization of the residue from isopropyl alcohol-ether afforded the title compound as a white solid (19.4 g).

[0734] .sup.1H-NMR (400 MHz, d.sub.6-DMSO Method M1); 8.60 (sb, 3H), 7.87 (s, 1H), 7.73 (dd, 1H), 7.56 (d, 1H), 6.22 (m, 1H), 3.44-3.21 (m, 2H).

[0735] LCMS (M-HCl+H).sup.+: 252.0, 254.0

Step 4: Synthesis of N-[2-(4-bromo-2-chlorophenyl)-2-fluoroethyl]-2-(trifluoromethyl)benzamide

[0736] ##STR00113##

[0737] To a solution of 2-(4-bromo-2-chlorophenyl)-2-fluoroethylamine hydrochloride (5 g, 17.3 mmol) in 75 mL of dichloromethane was added at 0 C. triethylamine (7.235 mL, 51.9 mmol) and dropwise 2-(trifluoromethyl)benzoyl chloride (4.3 g, 20.8 mmol). The reaction mixture was stirred at room temperature overnight. Then 30 mL of dichloromethane were added. The reaction mixture was washed with a solution of 1N HCl and then a saturated solution of NaHCO3. Evaporation led to a residue wish was purified by flash chromatography affording 5.5 g of the title compound.

[0738] .sup.1H-NMR (400 MHz, d.sub.6-DMSO Method M1); 8.91 (t, 1H), 7.82-7.63 (m, 5H), 7.54-7.45 (m, 2H), 6.00 (dt, 1H), 3.81-3.69 (m, 2H)

Step 5: Synthesis of N-{2-[2-chloro-4-(6-chloropyridin-3-yl)phenyl]-2-fluoroethyl}-2-(trifluoromethyl) benzamide (corresponds to product expl. 1-73)

[0739] ##STR00114##

[0740] To a solution of 200 mg of N-[2-(4-bromo-2-chlorophenyl)-2-fluoroethyl]-2-(trifluoromethyl)benzamide (0.47 mmol) in degased dioxane (5 mL) was added under argon (6-chloropyridin-3-yl)boronic acid (82 mg, 0.52 mmol), 1,1,-bis-(diphenylphosphino)-(ferrocen)-palladium(II)-dichlormethane (19 mg, 0.024 mmol) and 0.283 mL of an aqueous solution of sodium carbonate (60 mg, 0.57 mmol). The reaction was stirred at 80 C. for 2 hours. The reaction mixture was cooled down and some water and ethyl acetate were added. The two phases were separated and the organic phase was dried and evaporated. The residue obtained was purified by flash chromatography. This afforded 93 mg of the title compound.

[0741] .sup.1H-NMR: see NMR peak list in the table, example 1-73

[0742] LCMS (M+H).sup.+: 257.0, 459.0

Preparation Example 5

Synthesis of N-{2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-fluoropropyl}-2-(trifluoromethyl) benzamide (corresponds to product Example 1-101)

Step 1: Synthesis of 4-bromo-2-chloro-N-methoxy-N-methylbenzamide

[0743] ##STR00115##

[0744] To a solution of 4-bromo-2-chlorobenzoic acid (15 g, 63.69 mmol) in N-,N-dimethylformamide (150 mL) was added diisopropylethylamine (17.3 g, 133.7 mmol) followed by HBTU (26.6 g, 70.06 mmol) followed by MeNHOMe.HCl (6.2 g, 63.69 mmol). The reaction mixture was stirred at 70 C. for 10 hours, and then extracted with ethyl acetate ethyl acetate (250 mL). The organic layer was washed with water (50 mL), 1N HCl (50 mL), a saturated aqueous solution of sodium hyrogenocarbonate (50 mL), brine, was dried with sodium sulfate and filtrated. The organic phase was then concentrated in vacuo leading to a residue, which was purified by flash column chromatography (PE:EA=5:1). This afforded the title compound (13.3 g) as oil.

[0745] LCMS (M+H): 278.0, 280.0

Step 2: Synthesis of 1-(4-bromo-2-chlorophenyl)ethanone

[0746] ##STR00116##

[0747] To a solution of 4-bromo-2-chloro-N-methoxy-N-methylbenzamide (13.3 g, 47.76 mmol) in tetrahydrofurane (100 mL) was added methylmagnesiumbromide (71.63 mmol) at 60 C. under nitrogen. The reaction mixture was stirred at 60 C. for 1 hour, then stirred at 25 C. for 3 hours. A saturated aqueous solution of ammonium chloride was added. The reaction mixture was extracted with ethylacetate (100 mL) twice. The organic layer was washed by brine, dried with sodium sulfate and concentrated in vacuo. This afforded the title compound (9.7 g) as brown solid.

[0748] LCMS (M+H).sup.+: 233.1, 234.9

Step 3: Synthesis of 1-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]ethanone

[0749] ##STR00117##

[0750] To a solution of 1-(4-bromo-2-chlorophenyl)ethanone (9.7 g, 41.54 mmol) in toluene/dioxane/water (60 mL/20 mL/2 mL) was added (5-fluoropyridin-3-yl)boronic acid (7.6 g, 54.00 mmol), cesium carbonate (27 g, 83.08 mmol) and Pd(PPh.sub.3).sub.4 (4.8 g, 4.154 mmol) under nitrogen. The reaction mixture was heated at 100 C. for 8 hours, filtrated. The reaction mixture was then extracted with EtOAc (50 mL) twice, washed with brine and dried with sodium sulfate and concentrated under vacuo. After purification by flash column chromatography (PE:EA=10:1) this afforded the title compound (2.5 g) as white solid.

[0751] .sup.1H-NMR (400 MHz, d.sub.6-DMSO, Method M1); 8.90 (s, 1H), 8.65 (d, 1H), 8.22 (d, 1H), 8.02 (d, 1H), 7.82-7.93 (m, 2H), 2.63 (s, 3H)

[0752] LCMS (M+H).sup.+: 250.0

Step 4: Synthesis of 2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-hydroxypropanenitrile

[0753] ##STR00118##

[0754] Anhydrous zinc diodide (2.88 mg, 0.009 mmol) was placed in a three-necked round-bottomed flask fitted with an addition funnel under argon atmosphere. A solution of 1-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]ethanone (1.5 g, 6.01 mmol) in anhydrous dichloromethane (5 mL) was added and the contents were stirred at room temperature. The mixture was cooled to 0 C. and trimethylsilylcyanide (596.04 mL, 6.01 m mol) was added dropwise to the vigorously stirred reaction mixture. After addition, the reaction mixture returned to room temperature and was allowed to stir at that temperature overnight. Then the reaction was cooled down to 0 C. and additional dichloromethane (5 mL), anhydrous zinc diodide (2.88 mg, 0.009 mmol) and trimethylsilylcyanide (596.04 mL, 6.01 mmol) were added. After stirring an additional night at room temperature, another addition of dichloromethane (5 mL), anhydrous zinc diodide (2.88 mg, 0.009 mmol) and trimethylsilylcyanide (596.04 mL, 6.01 mmol) was performed at 0 C. and reaction mixture was stirred a third night at room temperature. 7.4 mL of dichloromethane as well as a solution of Diethylaminosulfur trifluoride (DAST) in dichloromethane (1.07 g, 6.61 mmol in 3.1 ml of dichloromethane) were added at 0 C. After overnight stirring at room temperature, 35 ml of cold water were added. The reaction mixture was extracted with dichloromethane. The phases were separated. The organic phase was washed with an aqueous solution of HCl (0.5N), then water, then a saturated solution of NaHCO3 and again water. After drying with sodium sulfate and evaporation, the residue obtained was purified by flash chromatography. This afforded 883 mg of the title compound.

[0755] .sup.1H-NMR (400 MHz, d.sub.6-DMSO, Method M1); 8.87 (s, 1H), 8.64 (d, 1H), 8.18 (m, 1H), 8.01 (d, 1H), 8.85 (m, 2H), 7.66 (s, 1H), 1.90 (s, 3H)

[0756] LCMS (M+H).sup.+: 277.1

Step 4: Synthesis of 2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-fluoropropanenitrile

[0757] ##STR00119##

[0758] To a solution of 2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-hydroxypropanenitrile in dichloromethane was added dropwise at 0 C., DAST in dichloromethane (463.5 mg, 2.88 mmol in 3.1 ml of dichloromethane). The reaction mixture was stirred overnight at room temperature. 35 mL of cold water were then added. The reaction mixture was extracted with dichloromethane. The phases were separated. The organic phase was washed with an aqueous solution of HCl (0.5N), then water, then a saturated solution of NaHCO3 and again water. After drying with sodium sulfate and evaporation, the residue obtained was purified by flash chromatography. This afforded 484 mg of the title compound.

[0759] .sup.1H-NMR (400 MHz, CD.sub.3CN, Method M1); 8.75 (t, 1H), 8.54 (d, 1H), 7.92 (d, 1H), 7.87 (m, 1H)

[0760] LCMS (M+H).sup.+: 279.1

Step 5: Synthesis of 2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-fluoropropan-1-amine hydrochloride

[0761] ##STR00120##

[0762] To a solution of 2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-fluoropropanenitrile (437 mg, 1.54 mmol) in dry tetrahydrofurane (20 mL) was added dropwise at 0 C. a solution of BH3.THF (1M, 4.610 mmol). The reaction mixture was brought to room temperature and stirred overnight at room temperature. Some ethanol was added. Some 1M HCL in diethylether was added and the reaction mixture was evaporated. To the residue obtained, was added 10 mL of acetone and MtBE. The solid obtained was separated by decantation leading to the title compound (562 mg).

[0763] .sup.1H-NMR (400 MHz, d.sub.6-DMSO, Method M1); 8.89 (s, 1H), 8.66 (d, 1H), 8.33 (s, 2H), 8.22 (dd, 1H), 8.04 (m, 1H), 7.93 (dd, 1H), 7.73 (d, 1H), 4.2 (bs, 2H), 1.97 (d, 3H)

[0764] LCMS (M+H-HCl).sup.+: 283.0

Step 6: Synthesis of N-{2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-fluoropropyl}-2-(trifluoromethyl)benzamide (corresponds to product expl. 1-101)

[0765] ##STR00121##

[0766] To a solution 2-[2-chloro-4-(5-fluoropyridin-3-yl)phenyl]-2-fluoropropan-1-amine hydrochloride (90 mg, 0.262 mmol) and triethyalmine (0.110 mL, 0.787 mmol) in dichloromethane (5 mL) was added dropwise 2-(trifluoromethyl)benzoyl chloride (0.046 mL, 0.315 mmol). The reaction was stirred at room temperature. After control by thin layer chromatography some water was added. The reaction mixture was extracted with ethyl acetate. The organic phase was washed with brine and dried with sodium sulfate. Evaporation led to a residue which was purified by flash chromatography. This afforded 68 mg of the title compound.

[0767] .sup.1H-NMR: see NMR peak list in the table, example 1-101.

[0768] LCMS (M+H).sup.+: 455.0

Preparation Example 6

Synthesis of N-{2-[2-chloro-4-(6-fluoropyridin-3-yl)phenyl]-2-fluoropropyl}-2-(trifluoromethyl) benzamide (corresponds to product expl. 1-130)

Step 1: Synthesis of 2-(2,4-dichlorophenyl)-2-fluoropropanenitrile

[0769] ##STR00122##

[0770] Trimethylsilylcyanide (5.3 mL, 39.7 mmol) was added dropwise to a stirred suspension of ZnI.sub.2 (19.036 mg, 0.06 mmol), 1-(2,4-dichlorophenyl)ethanone (7.516 g, 39.7 mmol) and dichloromethane (3.8 ml) under nitrogen atmosphere at 0 C. The reaction mixture was stirred at room temperature overnight. It was then diluted with dry dichloromethane (49 mL), cooled again to 0 C., and a solution of DAST (5.78 mL, 43.7 mmol) in dichloromethane (20.4 mL) was added dropwise. The reaction mixture was stirred overnight at room temperature. The reaction mixture is poured in 61 mL of iced water and extracted with dichloromethane. The organic layer was washed sequentially with a 0.5N aqueous HCl solution, water, a saturated aqueous solution of NaHCO3, and water again. The organic layer was dried over sodium sulfate, filtered, and concentrated. The residue obtained was further purified by flash chromatography on silicagel (eluent: cyclohexane/ethylacetate). This afforded 8.576 g of the title compound.

[0771] .sup.1H-NMR (400 MHz, CD.sub.3CN, Method M1); , 7.63 (m, 2H), 7.50 (dd, 1H), 2.20 (d, 3H);

Step 2: Synthesis of 2-(2,4-dichlorophenyl)-2-fluoropropan-1-amine hydrochloride

[0772] ##STR00123##

[0773] 9.79 g of 2-(2,4-dichlorophenyl)-2-fluoropropanenitrile (44.8 mmol) in anhydrous tetrahydrofurane (614 mL) were cooled to 0 C. 1 M borane-THF (134.6 mL, 134 mmol) was added dropwise. The reaction mixture returned to room temperature and was stirred at room temperature for 4 hours. It was then quenched with ethanol and was acidified with 1M HCl in diethyl ether and concentrated in vacuo. The residue was triturated with acetone and filtrated. This led to the 5.176 g of the title compound.

[0774] .sup.1H-NMR (400 MHz, d.sub.6-DMSO, Method M1); , 8.10 (s, 3H), 7.73 (s, 1H), 7.59 (m, 2H), 3.67-3.50 (m, 2H), 1.87 (d, 3H);

[0775] LCMS (M+H-HCl).sup.+: 220.0

Step 3: Synthesis N-[2-(2,4-dichlorophenyl)-2-fluoropropyl]-2-(trifluoromethyl)benzamide

[0776] ##STR00124##

[0777] 155 mg of 2-(2,4-dichlorophenyl)-2-fluoropropan-1-amine hydrochloride (0.56 mmol) were placed in dichloromethane (5 mL). Triethylamine (0.236 mL, 1.69 mmol) and 2-(trifluoromethyl)benzoyl chloride (141 mg, 0.67 mmol) were added. The reaction mixture was left under stirring at room temperature overnight. Some ethyl acetate was added. The organic phase was washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue obtained was purified by flash chromatography on silicagel (eluent: cyclohexane/ethylacetate). This afforded 174 mg (78%) of the title compound.

[0778] .sup.1H-NMR (400 MHz, CDCl.sub.3, Method M1); , 7.69 (m, 1H), 7.57-7.50 (m, 3H), 7.44 (d, 1H), 7.33 (m, 2H), 5.92 (s, 1H), 4.28-4.16 (m, 2H), 1.91 (d, 3H);

[0779] LC-MS: (M+H).sup.+: 395.0

Step 3: Synthesis of N-{2-[2-chloro-4-(6-fluoropyridin-3-yl)phenyl]-2-fluoropropyl}-2-(trifluoromethyl)benzamide (corresponds to product expl. 1-130)

[0780] ##STR00125##

[0781] To a solution of N-[2-(2,4-dichlorophenyl)-2-fluoropropyl]-2-(trifluoromethyl)benzamide (141 mg, 0.358 mmol) in degassed toluene (2.4 mL) was added under argon (6-fluoropyridin-3-yl)boronic acid (50 mg, 0.358 mmol), palladium acetate (12.0 mg, 0.054 mmol), an aqueous solution of potassium phosphate (276.4 mg, 1.302 mmol in 2.4 mL of water) and dicyclohexyl(2-6-dimethoxy-2-yl)phosphine (39.6 mg, 0.097 mmol). The reaction mixture was heated 30 minutes at reflux. The reaction mixture was cooled down and some methyl tertiary butyl ether was added. After filtration on celite, the reaction mixture was dried with sodium sulfate. After evaporation, the residue obtained was purified by flash chromatography on silicagel (eluent: cyclohexane/ethylacetate). This afforded 10.6 mg of the title compound.

[0782] .sup.1H-NMR: see NMR peak list in the table, example 1-130.

[0783] LC-MS: (M+H).sup.+: 455.1

Preparation of Intermediates

[0784] ##STR00126##

[0785] A mixture of 2-(4-bromo-2-chlorophenyl)-2,2-difluoro-1-ethanamine (preparation example 2, step 1) (35.2 g, 0.13 mol), 6-fluoropyridin-3-ylboronic acid (23 g, 0.163 mol) and potassium carbonate (19.8 g, 0.143 mol) in toluene (360 ml) and ethanol (125 ml) was de gassed with nitrogen. Tetrakis(triphenylphosphine)palladium(O) (15 g, 13 mmol) and a solution of potassium fluoride (22.6 g, 0.39 mol) in water (57 ml) were added and the mixture was degassed with nitrogen. Then the mixture was stirred at 70 C. for 19 hours and at r.t. for 40 hours.

[0786] The reaction mixture was diluted with water (300 ml) and the organic layer was separated. The water layer was extracted with diethyl ether (2*100 ml). The combined organic layers were mixed with 10% hydrochloric acid (500 ml) and the mixture was filtered. The filtercake was washed with ether and toluene. The filtrate was separated.

[0787] The water layer was combined with the solid material and the mixture was neutralized with sodium hydrogencarbonate then with sodium carbonate. Crude amine was extracted with ether (3150 ml). The extract was washed with water (150 ml), brine (150 ml), dried (Na.sub.2SO.sub.4) and treated with an ether-hydrogenchlorid solution.

[0788] The crude 2-[2-chloro-4-(6-fluoro-3-pyridyl)phenyl]-2,2-difluoro-1-ethanamine hydrochloride (32 g, 76% yield) was filtered off, washed with ether and dried in vacuo.

[0789] .sup.1H-NMR (400.0 MHz, DMSO, Method M1): =8.79 (bs, 3H, NH.sub.3), 8.69 (d, 1H), 8.45-8.40 (dt, 1H), 8.08 (s, 1H), 7.93-7.91 (d, 1H), 7.80-7.78 (d, 1H), 7.38-7.35 (dd, 1H), 3.92-3.81 (bt, 2H).

[0790] According to the methods described above, the following compounds of general formula (I) and intermediates (INT) have been prepared.

TABLE-US-00001 TABLE 1 Compounds of formula (I-1) [00127] R.sup.1, R.sup.2, Q, X, n, A are as defined by each individual structure. Example no. Formula 1-1 [00128] 1-2 [00129] 1-3 [00130] 1-4 [00131] 1-5 [00132] 1-6 [00133] 1-7 [00134] 1-8 [00135] 1-9 [00136] 1-10 [00137] 1-11 [00138] 1-12 [00139] 1-13 [00140] 1-14 [00141] 1-15 [00142] 1-16 [00143] 1-17 [00144] 1-18 [00145] 1-19 [00146] 1-20 [00147] 1-21 [00148] 1-22 [00149] 1-23 [00150] 1-24 [00151] 1-25 [00152] 1-26 [00153] 1-27 [00154] 1-28 [00155] 1-29 [00156] 1-30 [00157] 1-31 [00158] 1-32 [00159] 1-33 [00160] 1-34 [00161] 1-35 [00162] 1-36 [00163] 1-37 [00164] 1-38 [00165] 1-39 [00166] 1-40 [00167] 1-41 [00168] 1-42 [00169] 1-43 [00170] 1-44 [00171] 1-45 [00172] 1-46 [00173] 1-47 [00174] 1-48 [00175] 1-49 [00176] 1-50 [00177] 1-51 [00178] 1-52 [00179] 1-53 [00180] 1-54 [00181] 1-55 [00182] 1-56 [00183] 1-57 [00184] 1-58 [00185] 1-59 [00186] 1-60 [00187] 1-61 [00188] 1-62 [00189] 1-63 [00190] 1-64 [00191] 1-65 [00192] 1-66 [00193] 1-67 [00194] 1-68 [00195] 1-69 [00196] 1-70 [00197] 1-71 [00198] 1-72 [00199] 1-73 [00200] 1-74 [00201] 1-75 [00202] 1-76 [00203] 1-77 [00204] 1-78 [00205] 1-79 [00206] 1-80 [00207] 1-81 [00208] 1-82 [00209] 1-83 [00210] 1-84 [00211] 1-85 [00212] 1-86 [00213] 1-87 [00214] 1-88 [00215] 1-89 [00216] 1-90 [00217] 1-91 [00218] 1-92 [00219] 1-93 [00220] 1-94 [00221] 1-95 [00222] 1-96 [00223] 1-97 [00224] 1-98 [00225] 1-99 [00226] 1-100 [00227] 1-101 [00228] 1-102 [00229] 1-103 [00230] 1-104 [00231] 1-105 [00232] 1-106 [00233] 1-107 [00234] 1-108 [00235] 1-109 [00236] 1-110 [00237] 1-111 [00238] 1-112 [00239] 1-113 [00240] 1-114 [00241] 1-115 [00242] 1-116 [00243] 1-117 [00244] 1-118 [00245] 1-119 [00246] 1-120 [00247] 1-121 [00248] 1-122 [00249] 1-123 [00250] 1-124 [00251] 1-125 [00252] 1-126 [00253] 1-127 [00254] 1-128 [00255] 1-129 [00256] 130 [00257] 1-131 [00258] 1-132 [00259] 1-133 [00260] 1-134 [00261] 1-135 [00262] 1-136 [00263] 1-137 [00264] 1-138 [00265] 1-139 [00266] 1-140 [00267] 1-141 [00268] 1-142 [00269] 1-143 [00270] 1-144 [00271] 1-145 [00272] 1-146 [00273] 1-147 [00274] 1-148 [00275] 1-149 [00276] 1-150 [00277] 1-151 [00278] 1-152 [00279] 1-153 [00280] 1-154 [00281] 1-155 [00282] 1-156 [00283] Known from WO 2014004064 A1 (Cpd 150) [00284]

TABLE-US-00002 TABLE 2 Compounds of formula (INT) (INT) [00285] R.sup.1, R.sup.2, Q, X, n are as defined by each individual structure and might occur as salts like hydrochlorides. Example no. Formula NMR data INT-1 [00286] .sup.1H-NMR (400 MHz, d.sub.6-DMSO); 8.89 (s, 1 H), 8.66 (d, 1 H), 8.33 (s, 2 H), 8.22 (dd, 1 H), 8.04 (m, 1 H), 7.93 (dd, 1H), 7.73 (d, 1H), 4.2 (bs, 2H), 1.97 (d, 3H) INT-2 [00287] .sup.1H-NMR (400.0 MHz, DMSO): = 8.79 (bs, 3H, NH.sub.3.sup.+), 8.69 (d, 1H), 8.45-8.40 (dt, 1H), 8.08 (s, 1H), 7.93-7.91 (d, 1H), 7.80- 7.78 (d, 1H), 7.38-7.35 (dd, 1H), 3.92-3.81 (bt, 2H).

NMR Peak Lists

[0791] .sup.1H-NMR data of selected examples are written in form of .sup.1H-NMR-peak lists. The -value in ppm and the signal intensity are listed to each signal peak in round brackets. Between the -value-signal intensity pairs are semicolons as delimiters.

[0792] The peak list of an example has therefore the form:

.sub.1 (intensity.sub.1); .sub.2 (intensity.sub.2); . . . ; .sub.i (intensity.sub.i); . . . ; .sub.n (intensity.sub.n)

[0793] Intensity of sharp signals correlates with the height of the signals in a printed example of a NMR spectrum in cm and shows the real relations of signal intensities. From broad signals several peaks or the middle of the signal and their relative intensity in comparison to the most intensive signal in the spectrum can be shown.

[0794] Tetramethylsilane and/or the chemical shift of the used solvent, especially in the case of spectra measured in DMSO, have been used for calibrating. Therefore, tetramethylsilane peak can occur but not necessarily in NMR peak lists.

[0795] The .sup.1H-NMR peak lists are similar to classical .sup.1H-NMR prints and contain therefore usually all peaks, which are listed at classical NMR-interpretation.

[0796] Additionally they can show like classical .sup.1H-NMR prints signals of solvents, stereoisomers of the target compounds, which are also object of the invention, and/or peaks of impurities.

[0797] The usual peaks of solvents, for example peaks of DMSO in DMSO-D6 and the peak of water, are given in the .sup.1H-NMR peak lists to show compound signals in the delta-range of solvents and/or water. They have usually on average a high intensity.

[0798] The peaks of stereoisomers of the target compounds and/or peaks of impurities have usually on average a lower intensity than the peaks of target compounds (for example with a purity>90%).

[0799] Such stereoisomers and/or impurities can be typical for the specific preparation process. Therefore, their peaks can help to recognize the reproduction of our preparation process via side-products-fingerprints.

[0800] An expert, who calculates the peaks of the target compounds with known methods (MestreC, ACD-simulation, but also with empirically evaluated expectation values) can isolate the peaks of the target compounds as needed optionally using additional intensity filters. This isolation would be similar to relevant peak picking at classical .sup.1H-NMR interpretation.

[0801] Further details of NMR-data description with peak lists you find in the publication Citation of NMR Peaklist Data within Patent Applications of the Research Disclosure Database Number 564025.

TABLE-US-00003 TABLE 3 NMR Peaklists (Method M1) Example 1-1: .sup.1H-NMR(400.0 MHz, DMSO): = 8.622(2.1); 8.609(4.3); 8.595(2.1); 8.544(0.4); 8.539(0.4); 8.520(8.1); 8.519(8.4); 8.514(8.6); 8.513(8.1); 8.160(0.3); 8.153(0.4); 8.136(6.6); 8.129(6.3); 8.114(6.8); 8.108(6.7); 7.769(4.1); 7.751(5.7); 7.747(5.1); 7.676(1.5); 7.660(4.4); 7.658(4.2); 7.643(5.2); 7.639(6.2); 7.635(4.6); 7.618(4.0); 7.616(4.0); 7.599(1.4); 7.577(8.4); 7.551(3.1); 7.548(3.9); 7.544(2.5); 7.531(4.2); 7.528(5.0); 7.450(0.4); 7.442(4.8); 7.431(0.8); 7.423(9.1); 7.412(0.5); 7.404(4.7); 7.388(5.0); 7.371(4.3); 7.327(0.4); 7.320(0.4); 7.294(5.2); 7.284(0.9); 7.275(4.0); 7.178(0.4); 7.157(0.4); 7.095(8.9); 7.094(8.6); 7.074(8.6); 7.072(8.3); 5.080(4.5); 5.058(14.8); 5.035(15.7); 5.012(5.4); 3.558(2.7); 3.541(5.9); 3.526(5.8); 3.508(2.9); 3.325(81.2); 2.919(5.0); 2.901(8.8); 2.883(4.4); 2.676(0.5); 2.671(0.7); 2.666(0.5); 2.524(2.2); 2.520(3.4); 2.511(40.2); 2.507(81.1); 2.502(107.9); 2.497(77.7); 2.493(36.1); 2.333(0.5); 2.329(0.7); 2.324(0.5); 1.989(0.8); 1.398(16.0); 1.175(0.4); 1.121(0.5); 0.982(0.5); 0.000(3.0) Example 1-2: .sup.1H-NMR(400.0 MHz, DMSO): = 8.903(3.6); 8.899(3.4); 8.635(1.0); 8.622(1.9); 8.608(1.1); 8.581(2.5); 8.578(2.6); 8.569(2.7); 8.566(2.5); 8.095(1.6); 8.091(1.9); 8.090(2.0); 8.085(1.5); 8.075(1.8); 8.071(2.1); 8.070(2.2); 8.065(1.5); 7.771(1.9); 7.753(2.5); 7.749(2.3); 7.670(0.7); 7.654(2.1); 7.638(4.3); 7.632(5.0); 7.626(4.7); 7.622(4.0); 7.595(2.4); 7.576(2.5); 7.503(1.8); 7.501(1.9); 7.491(2.0); 7.489(2.0); 7.483(2.0); 7.481(2.1); 7.473(2.7); 7.472(2.7); 7.455(3.9); 7.436(2.0); 7.393(2.1); 7.390(2.3); 7.374(2.0); 7.337(2.6); 7.318(2.0); 3.571(1.3); 3.554(3.1); 3.538(3.2); 3.521(1.5); 3.338(5.8); 2.938(2.5); 2.921(4.6); 2.903(2.3); 2.508(9.4); 2.503(11.8); 2.499(8.8); 2.495(4.6); 2.087(16.0) Example 1-3: .sup.1H-NMR(400.0 MHz, DMSO): = 8.938(0.4); 8.817(7.4); 8.813(13.3); 8.809(7.6); 8.682(0.4); 8.676(0.4); 8.628(2.8); 8.614(5.5); 8.601(2.9); 8.580(12.1); 8.573(12.4); 8.092(3.9); 8.086(5.3); 8.081(3.9); 8.066(4.0); 8.061(5.1); 8.059(5.2); 8.055(3.9); 7.770(5.5); 7.752(7.4); 7.749(7.0); 7.693(11.8); 7.676(2.3); 7.659(11.7); 7.639(16.0); 7.619(5.7); 7.601(1.8); 7.482(5.5); 7.463(11.5); 7.444(6.5); 7.392(6.9); 7.375(6.1); 7.363(7.8); 7.344(5.5); 7.260(1.7); 4.056(0.7); 4.038(2.2); 4.020(2.3); 4.002(0.8); 3.572(3.8); 3.555(8.9); 3.539(9.0); 3.522(4.3); 3.324(82.7); 2.935(7.4); 2.917(13.4); 2.899(6.7); 2.675(0.9); 2.671(1.3); 2.666(0.9); 2.524(4.1); 2.506(139.6); 2.502(181.3); 2.497(135.1); 2.333(0.9); 2.329(1.2); 2.324(0.9); 1.989(9.6); 1.397(0.6); 1.279(0.6); 1.262(0.6); 1.192(2.6); 1.175(5.1); 1.157(2.5); 1.138(0.3); 1.120(0.6); 0.982(0.6); 0.879(1.1); 0.870(3.0); 0.858(0.3); 0.000(1.3) Example 1-4: .sup.1H-NMR(400.0 MHz, DMSO): = 8.598(0.6); 8.585(1.2); 8.571(0.6); 8.466(1.8); 8.461(1.9); 8.453(1.8); 8.449(1.8); 7.767(1.3); 7.749(1.8); 7.745(1.6); 7.677(0.5); 7.661(1.4); 7.659(1.3); 7.644(1.7); 7.640(1.9); 7.636(1.5); 7.619(1.3); 7.617(1.3); 7.611(1.8); 7.606(1.8); 7.600(0.6); 7.591(2.0); 7.587(1.9); 7.436(1.0); 7.417(2.5); 7.398(1.7); 7.376(1.6); 7.359(1.3); 7.311(2.9); 7.297(2.0); 7.292(2.5); 7.278(2.7); 7.274(2.9); 7.267(2.2); 7.264(1.9); 7.248(1.1); 7.245(1.4); 4.038(0.6); 4.020(0.6); 3.544(0.9); 3.527(2.0); 3.512(2.0); 3.494(1.0); 3.326(14.7); 2.908(1.7); 2.890(3.1); 2.872(1.5); 2.524(0.6); 2.511(10.5); 2.506(20.7); 2.502(26.8); 2.497(19.2); 2.493(9.0); 2.427(16.0); 1.989(2.4); 1.192(0.7); 1.175(1.3); 1.157(0.7); 0.000(4.3) Example 1-5: .sup.1H-NMR(400.0 MHz, DMSO): = 8.595(0.7); 8.582(1.3); 8.568(0.7); 7.766(1.4); 7.748(1.8); 7.700(0.3); 7.692(3.5); 7.671(5.1); 7.653(1.4); 7.650(1.2); 7.638(1.4); 7.620(1.4); 7.603(0.5); 7.473(0.4); 7.445(1.0); 7.425(4.2); 7.404(3.0); 7.378(1.7); 7.360(1.4); 7.329(1.7); 7.310(1.3); 7.287(2.8); 7.276(1.7); 7.273(2.0); 7.257(1.1); 7.254(1.3); 4.055(0.4); 4.038(1.1); 4.020(1.1); 4.002(0.4); 3.542(0.9); 3.525(2.0); 3.510(2.0); 3.492(1.0); 3.471(0.4); 3.457(0.4); 3.323(56.8); 2.905(1.6); 2.887(3.0); 2.869(1.5); 2.821(0.5); 2.675(0.6); 2.670(0.7); 2.666(0.6); 2.524(2.2); 2.519(3.5); 2.510(40.4); 2.506(80.9); 2.501(106.2); 2.497(76.5); 2.492(36.2); 2.408(16.0); 2.333(0.5); 2.328(0.7); 2.324(0.5); 2.086(0.4); 1.989(4.8); 1.249(0.4); 1.192(1.3); 1.174(2.7); 1.157(1.3); 0.008(0.5); 0.000(16.4); 0.009(0.5) Example 1-6: .sup.1H-NMR(400.0 MHz, DMSO): = 10.565(2.3); 8.625(0.8); 8.612(1.5); 8.598(0.8); 8.386(2.2); 8.365(2.8); 8.352(2.9); 7.765(1.4); 7.747(1.9); 7.744(1.8); 7.671(0.5); 7.654(1.5); 7.637(2.2); 7.633(2.4); 7.613(1.4); 7.591(3.2); 7.572(1.4); 7.553(2.0); 7.498(1.5); 7.479(2.8); 7.460(1.4); 7.408(2.1); 7.404(2.2); 7.395(3.8); 7.391(5.1); 7.372(2.5); 3.545(0.9); 3.528(2.1); 3.512(2.2); 3.495(1.0); 3.323(36.4); 2.936(1.8); 2.918(3.2); 2.900(1.6); 2.675(0.4); 2.671(0.6); 2.666(0.4); 2.510(34.7); 2.506(65.6); 2.501(84.2); 2.497(61.4); 2.493(30.4); 2.333(0.4); 2.328(0.6); 2.324(0.4); 2.121(16.0); 1.069(1.2); 0.000(0.6) Example 1-7: .sup.1H-NMR(400.0 MHz, DMSO): = 8.641(13.9); 8.638(9.5); 8.630(11.1); 8.626(16.0); 8.614(4.5); 8.600(2.2); 7.769(4.3); 7.751(5.7); 7.747(5.3); 7.724(15.3); 7.720(9.9); 7.713(10.0); 7.709(15.1); 7.698(9.5); 7.670(6.1); 7.651(9.6); 7.638(8.7); 7.633(8.3); 7.617(4.2); 7.598(1.3); 7.493(4.2); 7.474(9.0); 7.454(5.0); 7.384(11.1); 7.366(8.1); 3.564(3.0); 3.547(7.1); 3.532(7.1); 3.514(3.3); 3.327(24.0); 2.940(5.9); 2.922(10.6); 2.905(5.2); 2.675(0.4); 2.671(0.5); 2.666(0.4); 2.540(0.4); 2.506(59.5); 2.502(75.8); 2.497(55.6); 2.333(0.4); 2.329(0.5); 2.324(0.4); 0.000(0.6) Example 1-8: .sup.1H-NMR(400.0 MHz, DMSO): = 9.149(0.6); 8.882(14.8); 8.878(14.8); 8.626(16.0); 8.621(15.5); 8.612(5.8); 8.599(2.8); 8.261(9.5); 8.256(15.9); 8.250(8.9); 7.771(5.5); 7.753(7.5); 7.749(6.8); 7.693(11.7); 7.681(2.3); 7.678(2.3); 7.659(11.1); 7.639(15.0); 7.621(5.3); 7.602(1.7); 7.489(0.4); 7.479(5.8); 7.470(0.7); 7.460(12.1); 7.441(6.7); 7.392(6.8); 7.375(6.0); 7.363(7.7); 7.344(5.3); 4.038(0.4); 4.020(0.4); 3.573(3.8); 3.556(8.7); 3.541(8.7); 3.523(4.1); 3.326(44.9); 2.934(7.2); 2.916(13.1); 2.898(6.4); 2.695(0.6); 2.676(0.6); 2.671(0.8); 2.667(0.6); 2.525(2.9); 2.511(43.4); 2.507(84.7); 2.502(109.9); 2.498(79.0); 2.493(37.6); 2.334(0.5); 2.329(0.7); 2.324(0.5); 1.989(1.6); 1.337(0.5); 1.259(0.3); 1.249(0.6); 1.193(0.5); 1.175(0.9); 1.157(0.4); 0.008(1.3); 0.000(32.9); 0.009(1.1) Example 1-9: .sup.1H-NMR(400.0 MHz, DMSO): = 8.745(4.1); 8.740(4.2); 8.628(1.1); 8.614(2.1); 8.600(1.1); 8.185(2.6); 8.179(2.5); 8.164(2.8); 8.158(2.8); 8.142(2.4); 7.954(2.3); 7.770(2.2); 7.752(2.9); 7.683(0.8); 7.666(2.4); 7.642(6.8); 7.621(6.4); 7.600(5.2); 7.587(2.8); 7.476(2.0); 7.457(4.0); 7.438(2.2); 7.392(2.7); 7.374(2.3); 7.351(2.9); 7.332(2.1); 3.756(0.4); 3.744(0.4); 3.732(0.4); 3.564(1.5); 3.547(3.3); 3.531(3.4); 3.514(1.6); 3.329(1.8); 3.088(0.5); 3.079(0.7); 3.062(0.7); 3.025(0.5); 3.011(0.8); 2.997(0.6); 2.930(2.7); 2.912(4.9); 2.891(16.0); 2.732(12.5); 2.547(1.3); 2.507(31.5); 2.503(39.4); 2.498(29.2); 2.409(0.3); 2.087(0.5); 1.646(0.5); 1.633(0.4); 1.255(0.9); 1.239(0.9); 1.188(0.4); 1.170(0.8); 1.152(0.4); 0.000(9.0); 0.008(0.4) Example 1-10: .sup.1H-NMR(400.0 MHz, DMSO): = 9.245(0.7); 9.103(12.8); 8.636(3.8); 8.623(7.0); 8.609(3.7); 8.568(0.6); 8.550(0.6); 8.391(6.5); 8.371(7.1); 8.366(6.8); 8.316(1.1); 8.154(0.3); 8.117(0.8); 8.096(0.7); 8.003(12.8); 7.983(11.5); 7.807(0.4); 7.769(7.6); 7.750(10.1); 7.723(14.7); 7.692(7.6); 7.673(9.7); 7.666(9.6); 7.647(8.4); 7.642(8.9); 7.620(7.3); 7.601(2.6); 7.578(0.4); 7.564(0.4); 7.520(6.1); 7.501(12.7); 7.482(7.2); 7.454(0.4); 7.444(0.4); 7.404(11.1); 7.401(11.2); 7.382(9.6); 5.757(1.9); 3.649(0.3); 3.632(0.4); 3.578(4.7); 3.561(11.1); 3.546(11.2); 3.528(5.2); 3.511(0.6); 3.499(0.4); 3.480(0.4); 3.437(0.4); 3.323(347.0); 3.258(0.6); 3.228(0.5); 3.215(0.4); 3.179(0.4); 3.113(0.3); 3.091(0.7); 3.074(0.4); 3.043(0.4); 3.033(0.3); 2.990(0.4); 2.975(0.6); 2.952(9.0); 2.934(16.0); 2.916(8.2); 2.891(0.9); 2.792(0.3); 2.773(0.5); 2.756(0.5); 2.746(0.4); 2.732(0.8); 2.714(0.5); 2.671(5.0); 2.633(1.0); 2.616(1.0); 2.613(1.0); 2.506(593.5); 2.502(697.3); 2.497(502.8); 2.406(1.2); 2.390(0.8); 2.368(0.6); 2.357(0.6); 2.328(4.8); 2.294(0.4); 2.249(0.4); 2.238(0.4); 1.803(1.2); 1.785(1.9); 1.750(1.9); 1.680(0.5); 1.665(1.0); 1.398(0.7); 1.322(0.5); 1.300(1.0); 1.273(1.5); 1.242(2.0); 1.215(2.0); 1.167(0.6); 1.149(0.7); 1.121(0.6); 1.102(0.4); 0.981(0.4); 0.146(0.6); 0.043(0.3); 0.034(0.5); 0.008(7.3); 0.000(116.6); 0.150(0.6) Example 1-11: .sup.1H-NMR(601.6 MHz, DMSO): = 8.632(1.9); 8.623(3.7); 8.614(1.9); 8.497(5.5); 8.489(5.7); 7.777(4.2); 7.764(16.0); 7.754(4.2); 7.751(12.6); 7.718(1.8); 7.707(4.4); 7.694(2.9); 7.646(2.7); 7.633(4.1); 7.614(6.3); 7.529(3.4); 7.527(3.3); 7.521(3.4); 7.518(3.2); 7.443(4.5); 7.431(4.2); 7.417(10.9); 7.403(10.2); 3.517(2.6); 3.506(5.0); 3.496(5.0); 3.483(2.9); 3.327(19.1); 2.898(4.6); 2.885(7.9); 2.873(4.4); 2.617(0.4); 2.613(0.6); 2.610(0.4); 2.541(26.0); 2.535(42.3); 2.523(1.3); 2.520(1.3); 2.517(1.1); 2.508(28.8); 2.505(64.7); 2.502(91.5); 2.499(65.6); 2.496(30.9); 2.389(0.4); 2.386(0.6); 2.383(0.4); 1.234(0.4); 0.000(1.8) Example 1-12: .sup.1H-NMR(601.6 MHz, DMSO): = 9.099(7.5); 9.096(7.5); 8.644(2.4); 8.635(4.8); 8.625(2.4); 8.372(3.8); 8.369(3.9); 8.359(4.3); 8.355(4.3); 7.984(8.2); 7.970(7.8); 7.799(14.1); 7.785(16.0); 7.780(6.0); 7.766(6.4); 7.722(2.4); 7.710(5.6); 7.697(3.6); 7.648(3.5); 7.636(5.1); 7.623(2.2); 7.456(13.9); 7.453(8.8); 7.443(13.6); 3.528(3.1); 3.516(6.2); 3.507(6.3); 3.494(3.6); 3.331(420.6); 2.997(0.5); 2.915(5.8); 2.902(9.9); 2.890(5.5); 2.615(0.6); 2.542(37.2); 2.524(1.0); 2.521(1.2); 2.518(1.1); 2.509(33.1); 2.506(72.4); 2.503(101.6); 2.500(73.3); 2.497(34.5); 2.387(0.6); 1.234(0.4); 0.000(1.6) Example 1-13: .sup.1H-NMR(400.0 MHz, DMSO): = 8.894(4.7); 8.889(4.6); 8.647(1.6); 8.634(3.1); 8.620(1.6); 8.566(3.2); 8.562(3.4); 8.554(3.3); 8.551(3.2); 8.081(2.3); 8.076(3.0); 8.071(2.3); 8.061(2.5); 8.056(3.3); 8.052(2.3); 7.783(3.4); 7.763(4.5); 7.729(1.5); 7.710(4.1); 7.699(9.3); 7.694(5.6); 7.678(10.5); 7.652(2.7); 7.633(3.5); 7.614(1.4); 7.492(3.0); 7.481(3.0); 7.473(3.0); 7.460(5.9); 7.439(3.6); 7.412(9.5); 7.391(8.2); 3.529(2.1); 3.512(4.5); 3.497(4.4); 3.479(2.3); 3.333(9.2); 2.903(4.0); 2.884(6.7); 2.866(3.6); 2.525(0.5); 2.512(8.2); 2.508(15.9); 2.503(20.5); 2.499(14.8); 2.494(7.1); 2.087(16.0); 1.990(0.4); 0.000(1.9) Example 1-14: .sup.1H-NMR(400.0 MHz, DMSO): = 8.811(1.3); 8.807(2.4); 8.802(1.3); 8.646(0.5); 8.632(1.0); 8.618(0.5); 8.562(2.2); 8.555(2.3); 8.080(0.7); 8.075(0.9); 8.069(0.7); 8.054(0.7); 8.049(0.9); 8.043(0.7); 7.782(1.1); 7.767(3.6); 7.747(3.5); 7.729(0.5); 7.711(1.2); 7.692(0.9); 7.653(0.9); 7.634(1.1); 7.615(0.4); 7.453(1.3); 7.434(1.2); 7.422(3.1); 7.402(2.7); 3.932(2.5); 3.528(0.7); 3.511(1.4); 3.496(1.4); 3.478(0.7); 3.328(6.7); 2.907(1.3); 2.888(2.2); 2.870(1.1); 2.512(4.4); 2.508(8.9); 2.503(11.9); 2.498(8.6); 2.494(4.2); 1.160(0.5); 1.071(16.0); 0.000(6.6) Example 1-15: .sup.1H-NMR(400.0 MHz, DMSO): = 9.099(1.0); 8.737(8.1); 8.731(7.7); 8.637(2.8); 8.624(4.5); 8.610(2.1); 8.375(0.6); 8.356(0.6); 8.316(1.4); 8.169(5.1); 8.163(4.8); 8.148(5.3); 8.142(5.0); 7.986(1.0); 7.966(0.9); 7.802(1.8); 7.781(7.0); 7.761(6.8); 7.726(3.2); 7.713(14.6); 7.692(16.0); 7.651(4.4); 7.632(5.4); 7.606(8.5); 7.585(7.5); 7.450(6.4); 7.432(5.9); 7.414(12.4); 7.394(10.4); 3.519(3.7); 3.502(7.0); 3.487(6.6); 3.469(2.9); 3.322(42.8); 2.919(1.0); 2.897(6.3); 2.879(9.5); 2.861(4.6); 2.675(0.9); 2.671(1.1); 2.667(0.8); 2.506(140.5); 2.502(166.6); 2.498(119.4); 2.333(0.9); 2.329(1.1); 2.324(0.8); 1.989(1.2); 1.398(1.0); 1.193(0.3); 1.175(0.6); 1.157(0.3); 0.146(0.6); 0.000(112.1); 0.150(0.5) Example 1-16: .sup.1H-NMR(400.0 MHz, DMSO): = 8.876(10.3); 8.872(10.2); 8.811(2.3); 8.796(8.3); 8.784(7.0); 8.612(9.6); 8.607(9.8); 8.250(6.4); 8.244(10.7); 8.239(5.9); 7.931(4.2); 7.914(5.5); 7.790(4.7); 7.778(5.5); 7.770(16.0); 7.758(4.8); 7.749(14.0); 7.426(12.9); 7.405(11.3); 3.548(2.8); 3.531(6.3); 3.516(6.3); 3.498(3.2); 3.460(0.3); 3.402(0.6); 3.392(0.7); 3.377(1.3); 3.372(1.5); 3.341(835.2); 3.294(0.8); 3.285(0.5); 2.907(5.3); 2.889(9.5); 2.871(4.8); 2.676(1.1); 2.672(1.6); 2.667(1.2); 2.564(0.4); 2.542(71.1); 2.512(99.0); 2.507(195.3); 2.503(251.6); 2.498(179.2); 2.334(1.1); 2.330(1.6); 2.325(1.1); 1.258(0.4); 1.234(1.2); 0.008(0.5); 0.000(14.3) Example 1-17: .sup.1H-NMR(400.0 MHz, DMSO): = 8.789(1.9); 8.782(1.6); 8.449(2.0); 8.443(2.0); 7.981(1.4); 7.975(1.3); 7.960(1.4); 7.953(1.4); 7.932(1.0); 7.914(1.3); 7.787(1.1); 7.775(1.1); 7.767(0.9); 7.756(0.9); 7.610(2.9); 7.590(3.5); 7.362(3.1); 7.341(2.7); 6.827(2.0); 6.806(2.0); 5.314(0.4); 5.298(1.1); 5.283(1.5); 5.267(1.1); 5.252(0.4); 3.530(0.7); 3.513(1.5); 3.497(1.5); 3.480(0.8); 3.375(0.8); 3.342(269.1); 2.875(1.3); 2.857(2.2); 2.839(1.1); 2.676(0.4); 2.672(0.5); 2.667(0.4); 2.542(3.1); 2.512(30.9); 2.507(61.9); 2.503(80.6); 2.498(58.2); 2.494(28.1); 2.334(0.4); 2.329(0.5); 2.325(0.3); 1.320(16.0); 1.304(15.9); 0.000(6.5) Example 1-18: .sup.1H-NMR(400.0 MHz, DMSO): = 8.805(2.9); 8.792(10.5); 8.780(7.3); 8.511(9.3); 8.505(9.4); 8.123(6.3); 8.116(5.8); 8.101(6.5); 8.095(6.3); 7.933(4.8); 7.916(6.1); 7.788(5.1); 7.776(5.1); 7.768(4.2); 7.756(4.0); 7.653(13.6); 7.633(16.0); 7.386(14.5); 7.366(12.3); 7.089(9.4); 7.068(9.1); 5.075(4.7); 5.053(15.2); 5.030(15.8); 5.007(5.4); 3.537(3.0); 3.520(6.8); 3.504(6.8); 3.486(3.3); 3.468(0.5); 3.457(0.5); 3.438(0.4); 3.425(0.7); 3.403(1.2); 3.386(2.4); 3.350(1189.1); 3.291(1.0); 3.284(0.9); 3.269(0.8); 3.256(0.6); 3.217(0.4); 2.886(5.7); 2.868(10.0); 2.850(5.1); 2.677(1.3); 2.672(1.7); 2.668(1.2); 2.543(35.9); 2.512(110.6); 2.508(215.7); 2.503(275.5); 2.499(194.3); 2.494(90.6); 2.441(0.4); 2.334(1.3); 2.330(1.6); 2.326(1.2); 1.235(1.1); 0.000(4.9) Example 1-19: .sup.1H-NMR(400.0 MHz, DMSO): = 9.241(0.4); 9.101(8.0); 9.096(7.9); 8.816(2.4); 8.803(5.2); 8.793(6.9); 8.785(6.4); 8.378(3.9); 8.372(4.0); 8.357(4.3); 8.352(4.4); 8.120(0.5); 8.099(0.4); 7.991(8.6); 7.970(7.8); 7.936(4.6); 7.919(5.8); 7.805(13.6); 7.789(10.2); 7.785(16.0); 7.778(6.9); 7.770(4.2); 7.758(4.0); 7.466(13.9); 7.445(12.2); 3.560(2.9); 3.542(6.6); 3.527(6.7); 3.509(3.2); 3.337(402.3); 3.305(0.7); 2.997(0.7); 2.923(5.6); 2.905(10.1); 2.887(5.1); 2.676(1.0); 2.672(1.3); 2.668(1.0); 2.558(0.4); 2.542(56.5); 2.525(3.8); 2.512(81.2); 2.507(163.7); 2.503(212.9); 2.498(152.6); 2.494(73.1); 2.334(1.0); 2.329(1.3); 2.325(0.9); 1.807(0.4); 1.785(0.6); 1.755(0.5); 1.299(0.4); 1.267(0.5); 1.259(0.5); 1.234(1.3); 1.214(0.6); 1.192(0.4); 0.008(1.3); 0.000(36.3); 0.009(1.4) Example 1-20: .sup.1H-NMR(400.0 MHz, DMSO): = 20.011(0.4); 15.549(0.4); 14.283(0.4); 8.804(2.7); 8.791(9.8); 8.779(7.3); 8.739(9.1); 8.732(9.4); 8.171(6.1); 8.164(6.0); 8.150(6.8); 8.143(6.4); 7.931(4.8); 7.911(5.8); 7.787(5.2); 7.775(5.1); 7.768(4.2); 7.756(4.1); 7.716(13.9); 7.695(16.0); 7.610(9.8); 7.589(9.1); 7.420(14.4); 7.400(12.6); 3.722(0.5); 3.700(0.4); 3.672(0.4); 3.639(0.5); 3.603(0.4); 3.542(3.3); 3.525(7.1); 3.509(7.0); 3.491(3.8); 3.446(1.0); 3.433(1.1); 3.419(1.2); 3.406(1.6); 3.392(1.7); 3.337(2062.5); 3.289(1.8); 3.277(1.1); 3.094(0.4); 3.058(0.4); 2.996(0.5); 2.899(5.8); 2.881(10.4); 2.863(5.1); 2.712(0.5); 2.676(4.3); 2.671(5.8); 2.667(4.4); 2.636(0.5); 2.602(0.6); 2.578(0.8); 2.542(49.2); 2.525(14.1); 2.511(354.2); 2.507(724.5); 2.502(947.1); 2.498(672.4); 2.493(317.1); 2.464(1.5); 2.334(4.4); 2.329(5.9); 2.324(4.2); 2.289(0.4); 1.297(0.6); 1.258(0.8); 1.235(3.6); 0.853(0.5); 0.008(1.9); 0.000(68.1); 0.009(2.1); 1.700(0.5); 3.167(0.4) Example 1-21: .sup.1H-NMR(400.0 MHz, DMSO): = 8.811(7.8); 8.807(11.5); 8.803(7.4); 8.796(8.7); 8.783(7.1); 8.566(9.1); 8.559(9.2); 8.084(2.8); 8.079(4.0); 8.073(2.6); 8.058(2.9); 8.053(4.0); 8.047(2.6); 7.931(4.2); 7.914(5.5); 7.789(4.6); 7.777(5.6); 7.770(16.0); 7.757(5.1); 7.749(14.0); 7.427(12.8); 7.407(11.3); 3.549(2.8); 3.532(6.4); 3.516(6.4); 3.499(3.1); 3.390(0.5); 3.372(1.2); 3.336(511.2); 2.907(5.4); 2.889(9.6); 2.871(4.8); 2.712(0.4); 2.676(1.2); 2.672(1.5); 2.667(1.2); 2.542(86.1); 2.507(187.1); 2.503(241.3); 2.498(171.9); 2.368(0.3); 2.334(1.0); 2.329(1.5); 2.325(1.0); 1.259(0.3); 1.235(1.1); 0.008(1.5); 0.000(40.4); 0.009(1.4) Example 1-22: .sup.1H-NMR(400.0 MHz, DMSO): = 8.809(0.7); 8.793(2.9); 8.780(2.3); 8.473(1.4); 8.469(1.6); 8.461(1.5); 8.457(1.5); 7.927(1.4); 7.910(1.8); 7.786(1.6); 7.775(1.6); 7.767(1.3); 7.755(1.2); 7.625(0.9); 7.605(1.0); 7.388(1.3); 7.367(8.4); 7.359(8.9); 7.338(2.1); 7.325(0.9); 7.319(0.9); 7.305(0.8); 3.568(1.0); 3.551(2.2); 3.535(2.2); 3.518(1.1); 3.498(0.4); 3.491(0.4); 3.466(0.5); 3.445(0.6); 3.430(0.8); 3.410(0.9); 3.341(851.2); 3.283(1.3); 3.260(0.5); 3.243(0.3); 2.909(1.9); 2.890(3.2); 2.872(1.8); 2.712(0.5); 2.676(1.6); 2.672(2.2); 2.667(1.6); 2.542(116.9); 2.525(5.4); 2.520(7.8); 2.512(126.1); 2.507(263.0); 2.503(348.3); 2.498(247.5); 2.494(116.0); 2.468(0.7); 2.464(0.7); 2.444(16.0); 2.367(0.4); 2.338(0.7); 2.334(1.5); 2.329(2.1); 2.325(1.5); 2.290(0.5); 1.258(0.5); 1.235(1.4); 0.008(0.6); 0.000(21.5); 0.009(0.7) Example 1-23: .sup.1H-NMR(400.0 MHz, DMSO): = 8.894(8.3); 8.889(8.0); 8.811(2.3); 8.795(8.9); 8.782(7.2); 8.568(6.0); 8.564(6.3); 8.556(6.2); 8.552(6.1); 8.089(3.2); 8.083(4.2); 8.079(3.2); 8.069(3.5); 8.063(4.6); 8.059(3.2); 7.935(4.5); 7.918(5.8); 7.789(5.0); 7.777(4.9); 7.770(4.0); 7.758(3.8); 7.702(13.6); 7.682(16.0); 7.500(4.4); 7.488(4.3); 7.480(4.2); 7.469(3.9); 7.416(14.2); 7.396(12.2); 3.571(0.4); 3.548(3.2); 3.530(6.7); 3.515(6.8); 3.497(3.7); 3.474(0.5); 3.460(0.6); 3.444(1.0); 3.417(1.3); 3.378(4.6); 3.345(1223.4); 3.292(1.8); 3.262(0.8); 3.239(0.8); 3.225(0.5); 3.162(0.4); 3.015(0.6); 2.901(5.8); 2.883(10.1); 2.865(5.2); 2.753(0.5); 2.712(0.9); 2.677(1.9); 2.672(2.7); 2.667(2.0); 2.577(0.3); 2.542(220.5); 2.525(6.4); 2.512(163.1); 2.507(330.0); 2.503(430.1); 2.498(306.5); 2.494(144.3); 2.419(0.4); 2.415(0.4); 2.368(0.9); 2.334(2.0); 2.330(2.7); 2.325(2.0); 2.291(0.6); 1.298(0.4); 1.258(0.7); 1.234(1.9); 0.854(0.3); 0.000(9.9); 0.009(0.3) Example 1-24: .sup.1H-NMR(400.0 MHz, DMSO): = 8.787(4.8); 8.776(4.8); 8.748(1.9); 8.734(3.6); 8.720(1.9); 7.910(4.1); 7.891(5.3); 7.785(4.6); 7.773(4.6); 7.765(3.6); 7.753(3.4); 7.509(13.6); 7.488(16.0); 7.245(14.1); 7.224(12.1); 3.494(3.2); 3.476(7.4); 3.461(7.3); 3.444(3.4); 3.406(0.6); 3.398(0.5); 3.391(1.0); 3.338(825.0); 3.307(1.0); 3.293(0.6); 3.281(0.4); 2.811(5.9); 2.793(11.1); 2.775(5.3); 2.675(1.4); 2.672(1.9); 2.667(1.4); 2.542(22.5); 2.525(5.0); 2.511(114.0); 2.507(230.2); 2.502(300.7); 2.498(215.0); 2.494(102.6); 2.333(1.3); 2.329(1.8); 2.325(1.3); 2.320(0.6); 1.258(0.4); 1.236(1.2); 0.000(14.7); 0.009(0.4) Example 1-25: .sup.1H-NMR(400.0 MHz, DMSO): = 8.790(2.1); 8.778(2.3); 8.761(0.6); 7.930(1.2); 7.913(1.6); 7.785(1.4); 7.773(1.4); 7.765(1.1); 7.754(1.1); 7.564(3.0); 7.560(3.0); 7.401(3.0); 7.381(4.9); 7.316(4.5); 7.296(2.8); 6.688(2.9); 6.683(2.9); 3.520(0.8); 3.503(1.8); 3.487(1.8); 3.469(1.0); 3.366(0.9); 3.340(197.6); 3.307(0.3); 2.853(1.6); 2.835(2.7); 2.816(1.5); 2.676(0.3); 2.672(0.4); 2.542(9.3); 2.525(1.1); 2.511(26.5); 2.507(53.2); 2.503(68.9); 2.498(48.8); 2.494(23.0); 2.422(16.0); 2.334(0.3); 2.329(0.4); 1.236(0.4); 0.008(0.5); 0.000(14.6); 0.009(0.5) Example 1-26: .sup.1H-NMR(400.0 MHz, DMSO): = 8.789(6.3); 8.780(7.2); 8.778(7.0); 8.770(4.8); 8.755(2.3); 8.155(11.1); 7.921(4.6); 7.904(6.0); 7.902(5.9); 7.783(5.1); 7.771(5.1); 7.764(4.2); 7.752(4.0); 7.731(7.8); 7.727(12.9); 7.723(7.5); 7.567(13.6); 7.547(16.0); 7.288(14.4); 7.267(12.4); 6.949(9.2); 6.947(10.0); 6.945(9.9); 6.943(8.7); 3.571(0.4); 3.536(0.5); 3.512(3.5); 3.495(7.5); 3.479(7.3); 3.462(4.2); 3.380(1085.1); 3.312(1.2); 3.300(1.1); 3.289(1.0); 3.270(0.6); 3.259(0.4); 3.248(0.4); 3.232(0.4); 2.840(6.0); 2.822(10.2); 2.804(5.3); 2.679(0.7); 2.674(0.9); 2.670(0.7); 2.544(40.0); 2.527(2.3); 2.514(52.0); 2.510(103.6); 2.505(133.7); 2.501(95.3); 2.496(45.0); 2.336(0.6); 2.332(0.8); 2.327(0.6); 1.234(0.8); 0.008(1.2); 0.000(29.7); 0.009(1.0) Example 1-27: .sup.1H-NMR(400.0 MHz, DMSO): = 8.805(2.7); 8.792(10.7); 8.780(8.0); 8.461(9.8); 8.447(10.3); 7.926(4.9); 7.908(6.4); 7.895(0.6); 7.857(11.5); 7.854(12.1); 7.840(14.5); 7.819(16.0); 7.787(5.6); 7.775(6.0); 7.769(10.5); 7.766(9.5); 7.756(11.2); 7.752(7.5); 7.509(0.8); 7.488(0.9); 7.443(14.6); 7.423(13.1); 7.245(0.9); 7.224(0.7); 3.551(3.2); 3.534(7.3); 3.519(7.4); 3.501(3.5); 3.476(0.6); 3.462(0.6); 3.444(0.4); 3.439(0.4); 3.414(0.4); 3.406(0.5); 3.377(1.6); 3.340(941.1); 3.307(1.5); 3.281(0.6); 3.258(0.5); 3.251(0.4); 2.914(6.1); 2.896(11.1); 2.878(5.5); 2.812(0.4); 2.793(0.7); 2.774(0.4); 2.676(1.4); 2.672(1.9); 2.668(1.4); 2.542(46.6); 2.525(5.0); 2.512(117.2); 2.507(236.9); 2.503(309.7); 2.498(223.4); 2.494(108.4); 2.419(0.4); 2.334(1.4); 2.330(2.0); 2.325(1.4); 1.298(0.3); 1.258(0.5); 1.234(1.3); 0.008(1.4); 0.000(35.7); 0.008(1.3) Example 1-28: .sup.1H-NMR(400.0 MHz, DMSO): = 8.807(2.5); 8.792(10.1); 8.780(7.8); 8.297(9.3); 8.284(9.8); 7.927(4.9); 7.910(6.3); 7.847(14.3); 7.827(16.0); 7.787(5.3); 7.775(5.2); 7.768(4.3); 7.756(4.1); 7.720(3.6); 7.716(5.6); 7.712(3.9); 7.707(3.8); 7.703(5.4); 7.699(3.4); 7.533(11.6); 7.448(14.6); 7.428(13.2); 3.555(3.2); 3.537(7.4); 3.522(7.4); 3.504(3.5); 3.375(0.9); 3.339(418.0); 3.300(0.3); 2.917(6.2); 2.899(11.2); 2.882(5.6); 2.676(0.8); 2.672(1.1); 2.668(0.8); 2.542(11.0); 2.525(2.6); 2.512(65.9); 2.508(131.5); 2.503(170.5); 2.499(121.4); 2.494(57.5); 2.334(0.7); 2.330(1.0); 2.325(0.8); 1.234(0.8); 0.008(1.2); 0.000(33.1); 0.009(1.1) Example 1-29: .sup.1H-NMR(400.0 MHz, DMSO): = 8.805(2.6); 8.791(10.2); 8.778(7.7); 8.033(14.8); 8.012(16.0); 7.998(4.7); 7.996(5.1); 7.978(11.5); 7.976(10.1); 7.955(9.3); 7.936(16.0); 7.917(9.9); 7.788(5.2); 7.776(5.3); 7.769(4.3); 7.757(4.0); 7.465(9.0); 7.463(8.7); 7.446(8.4); 7.444(8.1); 7.424(14.5); 7.403(13.4); 3.628(0.4); 3.614(0.4); 3.596(0.4); 3.551(3.3); 3.534(7.2); 3.518(7.5); 3.501(3.7); 3.462(0.7); 3.438(1.0); 3.414(1.5); 3.401(1.8); 3.396(2.1); 3.386(2.9); 3.343(1848.6); 3.314(3.3); 3.294(1.5); 3.279(0.9); 3.264(0.7); 3.253(0.4); 3.241(0.5); 3.218(0.5); 2.910(6.0); 2.892(10.8); 2.874(5.4); 2.676(2.8); 2.672(3.6); 2.667(2.8); 2.582(0.4); 2.542(24.0); 2.525(10.1); 2.512(227.9); 2.507(455.1); 2.503(586.9); 2.498(414.0); 2.494(191.7); 2.452(0.6); 2.443(0.3); 2.334(2.4); 2.330(3.4); 2.325(2.5); 2.291(0.4); 1.297(0.4); 1.258(0.6); 1.234(1.6); 0.008(1.5); 0.000(37.6); 0.009(1.2) Example 1-30: .sup.1H-NMR(400.0 MHz, DMSO): = 8.804(0.9); 8.791(3.2); 8.780(2.3); 7.943(16.0); 7.922(1.4); 7.900(5.9); 7.879(4.4); 7.787(1.7); 7.774(1.6); 7.767(1.3); 7.755(1.2); 7.462(0.4); 7.447(4.2); 7.427(3.9); 7.250(0.3); 3.708(0.4); 3.649(0.3); 3.639(0.4); 3.570(0.4); 3.552(1.2); 3.533(2.4); 3.517(2.4); 3.501(1.2); 3.485(0.8); 3.474(0.6); 3.454(0.7); 3.432(1.3); 3.408(1.3); 3.399(1.4); 3.391(1.9); 3.384(2.5); 3.339(2092.8); 3.309(3.3); 3.303(2.4); 3.293(1.2); 3.283(1.1); 3.275(0.7); 3.269(0.5); 3.258(0.8); 3.233(0.4); 3.211(0.3); 3.199(0.3); 3.160(0.3); 2.918(1.9); 2.900(3.3); 2.882(1.6); 2.676(3.3); 2.672(4.4); 2.667(3.1); 2.598(0.6); 2.542(21.9); 2.511(266.6); 2.507(531.5); 2.502(689.2); 2.498(488.3); 2.494(229.2); 2.465(1.3); 2.456(0.8); 2.334(3.0); 2.329(4.2); 2.325(3.1); 2.290(0.5); 1.298(0.5); 1.258(0.7); 1.254(0.3); 1.233(1.3); 0.146(0.4); 0.008(3.0); 0.000(76.3); 0.009(2.6); 0.149(0.3) Example 1-31: .sup.1H-NMR(400.0 MHz, DMSO): = 8.700(1.9); 8.686(3.9); 8.672(1.9); 8.600(16.0); 8.570(9.0); 8.556(9.4); 7.787(4.0); 7.767(5.4); 7.732(1.7); 7.714(4.5); 7.701(9.5); 7.687(8.7); 7.658(3.3); 7.639(4.2); 7.627(8.9); 7.623(10.2); 7.532(4.9); 7.512(9.2); 7.480(5.1); 7.471(6.6); 7.467(6.7); 7.462(4.8); 7.452(3.6); 7.447(3.4); 3.574(2.2); 3.557(5.3); 3.541(5.4); 3.524(2.6); 3.384(0.6); 3.331(847.6); 3.274(0.5); 3.042(4.7); 3.023(8.2); 3.006(4.2); 2.995(2.0); 2.711(0.5); 2.675(1.7); 2.671(2.4); 2.667(1.7); 2.541(102.6); 2.506(274.3); 2.502(356.9); 2.497(258.9); 2.367(0.5); 2.333(1.7); 2.329(2.3); 2.324(1.7); 2.075(0.4); 1.298(0.4); 1.258(0.6); 1.235(2.5); 0.008(0.5); 0.000(11.4) Example 1-32: .sup.1H-NMR(400.0 MHz, DMSO): = 8.678(2.6); 8.664(5.4); 8.650(2.6); 8.565(9.3); 8.559(9.5); 8.179(6.1); 8.173(5.8); 8.157(6.3); 8.151(6.2); 8.142(0.4); 7.809(11.6); 7.804(12.0); 7.785(5.3); 7.766(6.9); 7.736(2.3); 7.717(5.8); 7.699(4.2); 7.665(5.6); 7.660(7.4); 7.645(7.1); 7.640(10.0); 7.619(2.1); 7.485(14.1); 7.465(12.7); 7.119(0.4); 7.099(9.9); 7.077(9.4); 5.083(4.8); 5.061(15.3); 5.038(16.0); 5.015(5.4); 3.541(2.8); 3.524(6.6); 3.508(6.7); 3.491(3.2); 3.331(423.8); 3.007(5.9); 2.989(10.1); 2.971(5.1); 2.712(0.5); 2.676(1.0); 2.671(1.4); 2.667(1.0); 2.663(0.5); 2.542(125.6); 2.525(4.0); 2.511(80.9); 2.507(161.8); 2.502(211.6); 2.498(151.9); 2.493(73.2); 2.368(0.5); 2.334(1.0); 2.329(1.4); 2.325(1.0); 1.235(1.4); 0.000(7.6) Example 1-33: .sup.1H-NMR(400.0 MHz, DMSO): = 8.931(11.5); 8.925(11.3); 8.684(3.2); 8.670(6.5); 8.656(3.2); 8.598(7.6); 8.594(8.1); 8.586(7.9); 8.582(8.0); 8.139(4.3); 8.134(6.0); 8.129(4.4); 8.119(4.7); 8.114(6.4); 8.109(4.5); 7.852(14.3); 7.848(15.1); 7.785(7.1); 7.766(9.3); 7.737(3.2); 7.718(8.3); 7.712(8.3); 7.707(7.2); 7.700(6.4); 7.692(8.8); 7.688(8.2); 7.657(5.6); 7.638(7.3); 7.619(2.7); 7.516(13.4); 7.510(7.3); 7.497(16.0); 7.489(8.9); 7.484(9.4); 7.480(8.3); 7.465(7.2); 3.553(4.0); 3.536(9.5); 3.520(9.6); 3.503(4.5); 3.407(0.3); 3.333(561.6); 3.022(8.3); 3.004(14.4); 2.986(7.2); 2.711(0.7); 2.676(1.2); 2.671(1.6); 2.667(1.2); 2.542(152.0); 2.507(189.6); 2.502(245.8); 2.498(180.4); 2.368(0.7); 2.333(1.1); 2.329(1.5); 2.325(1.1); 1.258(0.4); 1.234(1.6); 0.000(6.1) Example 1-34: .sup.1H-NMR(400.0 MHz, DMSO): = 8.680(3.1); 8.666(6.1); 8.652(3.1); 8.319(11.2); 8.305(11.7); 8.005(13.9); 8.000(14.2); 7.849(6.7); 7.844(6.4); 7.829(7.7); 7.824(7.4); 7.783(6.8); 7.764(13.2); 7.756(7.2); 7.752(4.4); 7.734(2.9); 7.716(7.2); 7.698(5.2); 7.656(5.2); 7.637(6.8); 7.616(16.0); 7.550(12.1); 7.530(10.6); 7.475(7.7); 7.457(6.6); 3.559(3.9); 3.541(9.1); 3.526(9.3); 3.509(4.5); 3.477(0.5); 3.457(0.5); 3.448(0.5); 3.429(0.7); 3.419(0.9); 3.408(1.0); 3.392(1.8); 3.333(1813.8); 3.282(0.7); 3.265(0.5); 3.035(7.6); 3.017(13.7); 2.999(6.7); 2.676(3.4); 2.671(4.6); 2.667(3.4); 2.541(56.3); 2.524(13.2); 2.511(271.9); 2.507(541.2); 2.502(706.5); 2.498(508.5); 2.493(244.9); 2.440(0.4); 2.333(3.3); 2.329(4.4); 2.324(3.3); 2.289(0.5); 2.075(0.5); 1.298(0.7); 1.258(1.1); 1.235(4.9); 0.853(0.5); 0.008(0.6); 0.000(16.8); 0.008(0.6) Example 1-35: .sup.1H-NMR(400.0 MHz, DMSO): = 8.652(2.9); 8.638(5.8); 8.624(2.9); 8.271(13.6); 7.782(6.3); 7.763(8.5); 7.752(8.8); 7.748(14.8); 7.744(8.8); 7.732(15.9); 7.728(16.0); 7.712(7.0); 7.694(5.0); 7.653(4.9); 7.634(6.3); 7.616(2.4); 7.572(6.3); 7.568(5.9); 7.552(7.6); 7.548(7.4); 7.470(7.4); 7.451(6.4); 7.388(11.8); 7.368(9.7); 7.025(11.9); 7.022(11.7); 3.518(3.6); 3.501(8.4); 3.485(8.5); 3.468(4.1); 3.393(0.4); 3.333(492.1); 3.287(0.4); 2.996(0.9); 2.963(7.3); 2.945(12.7); 2.927(6.4); 2.711(0.5); 2.676(1.1); 2.671(1.5); 2.667(1.1); 2.541(131.2); 2.524(4.0); 2.511(90.8); 2.507(179.2); 2.502(232.5); 2.498(168.1); 2.494(81.9); 2.368(0.6); 2.333(1.1); 2.329(1.5); 2.324(1.1); 1.258(0.4); 1.235(1.5); 0.000(6.2) Example 1-36: .sup.1H-NMR(400.0 MHz, DMSO): = 8.680(1.6); 8.666(3.3); 8.653(10.6); 8.649(6.9); 8.641(6.2); 8.637(9.7); 7.923(7.2); 7.918(7.5); 7.787(5.0); 7.783(6.7); 7.767(16.0); 7.763(14.1); 7.756(6.4); 7.752(9.7); 7.735(1.6); 7.716(3.8); 7.698(2.6); 7.656(2.6); 7.637(3.4); 7.618(1.3); 7.539(6.5); 7.519(5.6); 7.479(4.0); 7.460(3.4); 3.557(2.0); 3.540(4.6); 3.525(4.6); 3.507(2.2); 3.365(0.6); 3.334(254.1); 3.030(4.0); 3.012(7.1); 2.994(3.5); 2.676(0.6); 2.672(0.8); 2.667(0.6); 2.542(21.0); 2.525(2.1); 2.511(47.6); 2.507(96.0); 2.503(125.7); 2.498(90.0); 2.494(42.8); 2.334(0.6); 2.329(0.8); 2.325(0.6); 1.234(1.6); 0.000(4.2) Example 1-37: .sup.1H-NMR(400.0 MHz, DMSO): = 8.849(14.5); 8.685(3.8); 8.671(7.4); 8.657(3.7); 8.602(13.1); 8.595(13.2); 8.167(4.7); 8.162(6.6); 8.157(4.3); 8.141(4.8); 8.136(6.7); 8.131(4.2); 7.938(15.9); 7.933(15.9); 7.820(0.4); 7.785(9.2); 7.781(9.9); 7.776(8.5); 7.766(11.9); 7.761(11.1); 7.756(8.9); 7.737(3.6); 7.719(8.8); 7.700(6.3); 7.658(6.3); 7.639(8.1); 7.620(3.2); 7.576(0.4); 7.527(13.6); 7.507(11.9); 7.482(9.5); 7.463(8.1); 7.436(0.5); 3.554(4.5); 3.537(10.7); 3.521(11.0); 3.504(5.1); 3.475(0.5); 3.457(0.4); 3.333(476.2); 3.027(9.1); 3.009(16.0); 2.991(8.1); 2.948(0.4); 2.712(0.9); 2.676(1.7); 2.671(2.2); 2.542(181.3); 2.507(273.2); 2.503(339.2); 2.498(249.8); 2.368(0.9); 2.333(1.6); 2.329(2.1); 2.325(1.5); 2.075(0.4); 2.031(0.4); 1.867(0.4); 1.298(0.4); 1.258(0.6); 1.235(2.1); 0.000(8.7) Example 1-38: .sup.1H-NMR(400.0 MHz, DMSO): = 9.140(12.2); 9.136(12.2); 8.690(3.9); 8.676(7.5); 8.663(3.7); 8.438(6.2); 8.433(6.2); 8.417(6.6); 8.413(6.7); 8.316(0.4); 8.006(12.7); 7.986(12.4); 7.977(15.7); 7.972(15.8); 7.831(0.3); 7.810(7.5); 7.806(7.1); 7.786(16.0); 7.767(10.5); 7.737(3.6); 7.718(8.7); 7.700(6.3); 7.659(6.1); 7.639(8.0); 7.620(3.0); 7.565(13.1); 7.545(11.2); 7.484(9.4); 7.466(7.9); 3.687(0.3); 3.631(0.4); 3.596(0.4); 3.563(4.5); 3.546(10.7); 3.530(11.0); 3.513(5.1); 3.459(0.7); 3.437(1.0); 3.398(1.9); 3.330(2223.4); 3.254(0.5); 3.230(0.4); 3.041(8.8); 3.023(15.6); 3.005(7.7); 2.995(4.3); 2.859(0.4); 2.712(0.7); 2.675(6.8); 2.671(8.9); 2.667(6.8); 2.602(0.5); 2.541(114.6); 2.506(1101.2); 2.502(1388.2); 2.498(1042.5); 2.420(0.9); 2.368(0.7); 2.333(6.8); 2.329(8.8); 2.325(6.8); 2.288(0.8); 2.282(0.6); 2.263(0.5); 2.075(0.9); 1.518(0.4); 1.502(0.3); 1.496(0.3); 1.298(1.6); 1.258(2.4); 1.235(9.6); 0.889(0.3); 0.871(0.4); 0.854(1.0); 0.837(0.5); 0.000(42.0) Example 1-39: .sup.1H-NMR(400.0 MHz, DMSO): = 8.622(2.2); 8.608(4.2); 8.594(2.1); 7.777(5.2); 7.758(6.8); 7.732(2.3); 7.717(13.8); 7.712(16.0); 7.695(4.0); 7.653(4.0); 7.634(5.2); 7.615(2.0); 7.534(5.4); 7.529(5.2); 7.513(6.6); 7.508(6.4); 7.454(6.0); 7.435(5.2); 7.346(10.6); 7.325(8.6); 3.502(3.3); 3.485(8.2); 3.469(8.3); 3.452(3.8); 3.426(0.5); 3.341(328.7); 3.336(427.1); 2.932(6.5); 2.914(12.4); 2.897(5.7); 2.676(0.9); 2.671(1.3); 2.667(0.9); 2.542(70.7); 2.525(3.2); 2.511(72.6); 2.507(146.7); 2.502(193.3); 2.498(139.9); 2.494(68.0); 2.334(0.9); 2.329(1.2); 2.325(0.9); 1.235(1.2); 0.000(4.4) Example 1-40: .sup.1H-NMR(400.0 MHz, DMSO): = 8.661(0.7); 8.647(1.3); 8.633(0.7); 7.783(1.5); 7.763(1.9); 7.731(0.6); 7.713(1.6); 7.695(1.2); 7.655(1.2); 7.635(1.5); 7.616(0.6); 7.588(3.1); 7.583(3.1); 7.499(2.9); 7.496(2.9); 7.476(1.7); 7.457(1.5); 7.425(0.8); 7.405(4.1); 7.398(3.0); 7.394(2.6); 7.378(0.6); 7.374(0.6); 6.762(2.9); 6.757(2.9); 3.526(0.9); 3.509(1.9); 3.493(1.9); 3.476(1.0); 3.331(246.2); 2.995(0.5); 2.977(1.7); 2.959(2.8); 2.941(1.5); 2.675(0.6); 2.671(0.8); 2.666(0.6); 2.541(43.5); 2.524(2.2); 2.511(47.2); 2.506(96.2); 2.502(126.7); 2.497(91.6); 2.493(44.3); 2.468(0.5); 2.436(16.0); 2.333(0.6); 2.329(0.8); 2.324(0.6); 1.235(0.6); 0.000(4.3) Example 1-41: .sup.1H-NMR(400.0 MHz, DMSO): = 8.678(2.2); 8.664(4.5); 8.650(2.1); 8.133(9.7); 8.128(10.1); 8.078(6.1); 8.059(8.7); 8.028(5.0); 8.023(4.6); 8.008(5.3); 8.003(4.9); 7.987(6.2); 7.967(10.3); 7.948(4.8); 7.809(0.6); 7.805(0.7); 7.783(4.8); 7.763(6.2); 7.737(2.2); 7.718(5.3); 7.699(3.8); 7.680(0.4); 7.655(4.0); 7.636(4.9); 7.617(1.9); 7.537(8.2); 7.517(16.0); 7.498(7.9); 7.481(5.7); 7.463(4.8); 3.560(2.6); 3.543(6.3); 3.527(6.6); 3.510(3.4); 3.480(0.3); 3.470(0.3); 3.458(0.4); 3.424(0.6); 3.340(726.6); 3.336(727.4); 3.030(5.1); 3.013(9.3); 2.995(6.2); 2.971(0.4); 2.712(0.4); 2.676(1.6); 2.671(2.1); 2.667(1.5); 2.663(0.7); 2.542(85.1); 2.525(5.2); 2.511(127.2); 2.507(255.3); 2.502(333.6); 2.498(238.4); 2.493(113.1); 2.368(0.4); 2.338(0.8); 2.334(1.6); 2.329(2.1); 2.325(1.6); 1.258(0.4); 1.234(2.1); 0.000(9.2) Example 1-42: .sup.1H-NMR(400.0 MHz, DMSO): = 8.665(1.7); 8.481(1.9); 8.473(2.0); 7.785(1.8); 7.764(2.5); 7.731(0.9); 7.712(2.1); 7.694(1.6); 7.656(1.7); 7.636(3.6); 7.617(2.8); 7.498(3.8); 7.494(3.9); 7.481(3.3); 7.462(4.1); 7.364(2.3); 7.345(1.8); 7.326(1.6); 7.314(1.8); 7.295(1.4); 3.572(1.1); 3.555(2.6); 3.539(2.8); 3.523(1.3); 3.330(758.3); 3.027(2.3); 3.008(3.9); 2.995(2.5); 2.711(0.4); 2.671(3.3); 2.541(51.4); 2.502(511.1); 2.440(16.0); 2.367(0.4); 2.329(3.1); 2.289(0.4); 1.298(0.5); 1.258(0.8); 1.235(3.1); 0.854(0.3); 0.000(8.7) Example 1-43: .sup.1H-NMR(400.0 MHz, DMSO): = 8.674(0.7); 8.660(1.4); 8.646(0.7); 8.500(2.4); 8.493(2.4); 8.035(1.4); 8.029(1.3); 8.014(1.4); 8.007(1.4); 7.785(1.5); 7.765(2.0); 7.755(2.9); 7.750(2.9); 7.735(0.6); 7.717(1.6); 7.698(1.1); 7.656(1.2); 7.637(1.5); 7.622(1.6); 7.618(1.7); 7.602(1.6); 7.598(1.5); 7.480(1.7); 7.461(3.8); 7.441(1.9); 6.835(2.4); 6.814(2.3); 5.322(0.4); 5.307(1.1); 5.291(1.5); 5.276(1.2); 5.261(0.5); 3.535(0.8); 3.518(1.8); 3.502(1.9); 3.485(0.9); 3.333(259.8); 2.997(1.7); 2.979(2.7); 2.961(1.3); 2.671(0.7); 2.542(24.4); 2.507(85.8); 2.502(107.2); 2.498(79.5); 2.333(0.5); 2.329(0.7); 1.322(16.0); 1.306(15.9); 1.235(0.8); 0.000(2.1) Example 1-44: .sup.1H-NMR(400.0 MHz, DMSO): = 20.005(0.5); 8.680(3.4); 8.666(7.1); 8.652(3.6); 8.603(10.8); 8.597(11.3); 8.364(3.5); 8.358(3.5); 8.344(6.5); 8.337(6.3); 8.323(4.0); 8.317(4.0); 7.858(15.0); 7.854(15.9); 7.785(7.5); 7.765(10.1); 7.736(3.3); 7.717(8.5); 7.697(12.7); 7.682(8.9); 7.677(8.6); 7.657(6.2); 7.637(8.0); 7.618(3.2); 7.510(13.6); 7.490(11.9); 7.481(9.6); 7.462(8.1); 7.309(6.8); 7.302(6.8); 7.288(6.8); 7.281(6.6); 3.546(4.4); 3.530(10.3); 3.514(10.5); 3.496(4.9); 3.333(1943.2); 3.017(9.0); 2.998(16.0); 2.981(7.9); 2.711(1.6); 2.671(5.6); 2.541(321.8); 2.506(675.4); 2.502(850.6); 2.498(620.0); 2.368(1.5); 2.329(5.4); 2.289(0.4); 2.075(0.6); 1.298(0.8); 1.258(1.1); 1.235(4.3); 0.855(0.5); 0.000(20.4) Example 1-45: .sup.1H-NMR(400.0 MHz, DMSO): = 9.016(0.3); 8.916(15.8); 8.911(14.9); 8.711(0.4); 8.684(4.0); 8.671(7.5); 8.657(4.2); 8.644(14.3); 8.639(13.8); 8.332(9.9); 8.327(15.5); 8.322(8.5); 7.946(16.0); 7.941(15.3); 7.830(0.4); 7.786(9.1); 7.780(9.5); 7.775(8.5); 7.767(11.9); 7.760(10.5); 7.756(8.6); 7.738(3.6); 7.719(8.9); 7.700(6.3); 7.658(6.2); 7.639(8.0); 7.620(3.1); 7.523(12.8); 7.503(11.1); 7.481(9.3); 7.463(7.9); 3.551(4.5); 3.534(10.9); 3.519(11.3); 3.502(5.2); 3.472(0.5); 3.449(0.6); 3.430(0.7); 3.406(0.9); 3.332(1259.4); 3.265(1.0); 3.231(0.4); 3.025(9.0); 3.007(15.9); 2.995(6.5); 2.990(8.0); 2.711(0.7); 2.671(4.2); 2.541(157.2); 2.506(549.1); 2.502(657.8); 2.498(486.9); 2.400(0.4); 2.367(0.9); 2.329(4.2); 2.289(0.5); 2.282(0.3); 2.075(0.5); 1.298(0.7); 1.259(1.0); 1.235(4.3); 0.853(0.5); 0.000(15.0) Example 1-46: .sup.1H-NMR(400.0 MHz, DMSO): = 8.680(0.9); 8.666(1.7); 8.652(0.9); 8.083(3.5); 8.078(3.7); 8.021(16.0); 7.902(1.7); 7.897(1.6); 7.882(1.9); 7.877(1.8); 7.809(0.4); 7.805(0.4); 7.784(1.9); 7.765(2.5); 7.734(0.8); 7.716(2.1); 7.698(1.5); 7.657(1.6); 7.638(1.9); 7.619(0.7); 7.546(3.0); 7.525(2.7); 7.471(2.1); 7.453(1.8); 3.554(1.0); 3.537(2.3); 3.522(2.5); 3.505(1.2); 3.397(0.4); 3.334(534.8); 3.278(0.4); 3.034(1.9); 3.016(3.5); 2.998(1.8); 2.676(1.0); 2.671(1.4); 2.667(1.0); 2.541(14.4); 2.524(3.1); 2.511(78.2); 2.507(158.8); 2.502(210.2); 2.498(153.5); 2.493(75.5); 2.333(1.0); 2.329(1.3); 2.324(1.0); 1.258(0.4); 1.234(1.5); 0.000(5.3) Example 1-47: .sup.1H-NMR(400.0 MHz, DMSO): = 8.648(0.7); 8.634(1.4); 8.620(0.7); 8.202(4.6); 7.912(4.9); 7.781(1.5); 7.762(1.9); 7.729(0.6); 7.710(1.6); 7.692(1.2); 7.659(3.4); 7.654(4.2); 7.633(1.5); 7.615(0.6); 7.508(1.4); 7.504(1.4); 7.488(1.8); 7.484(1.8); 7.470(1.7); 7.451(1.5); 7.348(2.8); 7.328(2.2); 3.852(16.0); 3.505(0.8); 3.488(1.9); 3.472(1.9); 3.455(0.9); 3.332(115.8); 3.311(0.5); 2.995(0.4); 2.941(1.7); 2.923(2.9); 2.906(1.5); 2.671(0.4); 2.667(0.3); 2.541(39.4); 2.524(1.0); 2.511(26.1); 2.506(51.7); 2.502(67.0); 2.497(48.0); 2.493(23.1); 2.329(0.4); 1.235(0.5); 0.000(2.2) Example 1-48: .sup.1H-NMR(400.0 MHz, DMSO): = 8.697(2.9); 8.683(6.0); 8.669(2.9); 8.465(7.6); 8.460(8.2); 8.453(8.1); 8.448(7.9); 8.317(0.5); 7.924(7.7); 7.920(7.9); 7.905(8.9); 7.901(8.3); 7.787(6.2); 7.767(8.1); 7.730(2.7); 7.712(6.9); 7.693(5.2); 7.658(5.0); 7.639(6.2); 7.620(2.5); 7.601(13.6); 7.596(13.8); 7.556(8.4); 7.544(8.3); 7.537(7.8); 7.525(7.8); 7.514(7.7); 7.494(14.6); 7.476(7.4); 7.457(16.0); 7.453(12.3); 7.438(5.0); 7.433(4.9); 7.391(0.3); 4.852(0.4); 4.011(0.3); 3.626(0.4); 3.596(0.5); 3.569(3.7); 3.552(8.2); 3.536(8.4); 3.519(4.3); 3.489(0.6); 3.485(0.7); 3.478(0.7); 3.460(0.9); 3.437(0.9); 3.331(2964.6); 3.330(2877.3); 3.298(3.4); 3.264(0.7); 3.232(0.5); 3.035(7.3); 3.016(12.4); 2.999(6.5); 2.995(6.0); 2.711(0.9); 2.675(6.8); 2.671(9.2); 2.666(6.7); 2.662(3.2); 2.607(0.4); 2.541(197.1); 2.524(22.8); 2.511(533.8); 2.506(1080.9); 2.502(1420.4); 2.497(1020.4); 2.493(488.2); 2.420(0.6); 2.403(0.5); 2.380(0.4); 2.367(1.0); 2.333(6.5); 2.328(9.1); 2.324(6.5); 2.289(1.0); 2.282(0.7); 2.266(0.5); 2.180(0.3); 2.075(1.2); 1.298(1.8); 1.258(2.5); 1.235(9.9); 0.889(0.4); 0.870(0.4); 0.854(1.1); 0.836(0.5); 0.008(1.4); 0.000(45.5); 0.008(1.6) Example 1-49: .sup.1H-NMR(400.0 MHz, DMSO): = 20.013(1.8); 8.680(5.9); 7.991(8.9); 7.971(10.4); 7.785(5.9); 7.766(7.9); 7.729(2.5); 7.710(6.7); 7.695(13.6); 7.676(9.3); 7.657(5.2); 7.638(6.4); 7.619(14.4); 7.522(5.8); 7.502(11.1); 7.465(10.2); 3.548(8.3); 3.533(8.8); 3.334(5269.3); 3.032(7.5); 3.014(12.7); 2.995(8.3); 2.670(16.0); 2.541(153.4); 2.502(2412.8); 2.329(15.3); 2.074(1.2); 1.298(2.6); 1.258(3.4); 1.235(15.9); 0.854(1.5); 0.000(40.5) Example 1-50: .sup.1H-NMR(400.0 MHz, DMSO): = 8.657(0.6); 8.644(1.2); 8.629(0.6); 7.780(1.2); 7.760(1.6); 7.728(0.5); 7.710(1.3); 7.692(1.0); 7.654(1.0); 7.634(1.2); 7.615(0.5); 7.498(2.6); 7.493(2.8); 7.470(1.5); 7.464(2.0); 7.451(1.4); 7.444(2.9); 7.391(1.9); 7.387(1.7); 7.371(1.1); 7.367(1.1); 3.544(0.7); 3.527(1.7); 3.511(1.7); 3.494(0.8); 3.384(0.4); 3.341(182.0); 3.337(196.2); 2.995(1.7); 2.977(2.6); 2.959(1.3); 2.676(0.4); 2.671(0.5); 2.667(0.4); 2.624(14.1); 2.542(24.2); 2.525(1.2); 2.511(29.9); 2.507(61.8); 2.502(82.0); 2.498(59.1); 2.493(28.3); 2.380(16.0); 2.334(0.4); 2.329(0.5); 2.324(0.4); 1.235(0.5); 0.000(2.0) Example 1-51: .sup.1H-NMR(400.0 MHz, DMSO): = 8.644(2.2); 8.631(4.2); 8.617(2.2); 8.296(7.2); 8.283(7.6); 7.846(11.2); 7.825(12.4); 7.781(4.7); 7.762(6.1); 7.726(2.5); 7.716(5.4); 7.708(8.1); 7.690(3.9); 7.652(3.7); 7.633(4.7); 7.614(1.8); 7.533(9.9); 7.443(16.0); 7.423(13.1); 3.531(2.7); 3.514(6.3); 3.499(6.3); 3.481(3.0); 3.374(0.3); 3.335(122.0); 2.998(0.9); 2.915(5.2); 2.897(9.3); 2.879(4.7); 2.672(0.5); 2.542(31.7); 2.507(55.2); 2.503(69.6); 2.499(52.5); 2.329(0.4); 0.000(1.1) Example 1-52: .sup.1H-NMR(400.0 MHz, DMSO): = 8.617(2.6); 8.604(4.9); 8.590(2.8); 8.179(0.3); 8.152(10.7); 8.137(1.3); 8.117(0.4); 7.783(5.1); 7.764(7.1); 7.753(1.3); 7.750(1.3); 7.747(1.3); 7.730(8.1); 7.726(14.0); 7.722(8.5); 7.708(6.8); 7.689(4.9); 7.653(4.3); 7.635(5.5); 7.616(2.5); 7.566(13.2); 7.546(16.0); 7.471(0.4); 7.442(6.0); 7.424(5.6); 7.285(13.9); 7.265(12.8); 6.976(0.4); 6.948(9.6); 6.945(9.5); 6.932(1.3); 3.876(0.3); 3.833(0.4); 3.818(0.5); 3.806(0.5); 3.792(0.5); 3.771(0.6); 3.763(0.6); 3.747(0.5); 3.737(0.5); 3.724(0.5); 3.707(0.7); 3.699(0.6); 3.662(0.8); 3.637(1.3); 3.627(1.2); 3.605(1.1); 3.589(1.6); 3.584(1.4); 3.561(2.2); 3.489(15.5); 3.411(3110.0); 3.392(392.5); 3.280(3.4); 3.249(2.0); 3.239(1.9); 3.224(2.0); 3.202(1.5); 3.176(1.0); 3.143(0.9); 3.122(0.8); 3.102(0.8); 3.084(0.7); 3.045(0.6); 3.023(0.5); 3.010(0.4); 2.998(3.6); 2.985(0.6); 2.914(0.4); 2.892(0.4); 2.839(6.4); 2.821(10.6); 2.803(6.5); 2.756(0.3); 2.718(0.6); 2.683(1.3); 2.678(1.7); 2.674(1.4); 2.623(0.4); 2.548(105.1); 2.531(19.0); 2.518(104.2); 2.514(187.9); 2.509(239.4); 2.505(178.8); 2.500(99.3); 2.418(0.4); 2.374(0.7); 2.361(0.3); 2.340(1.3); 2.336(1.6); 2.331(1.3); 2.312(0.4); 1.261(0.3); 1.237(0.8); 0.002(0.4) Example 1-53: .sup.1H-NMR(400.0 MHz, DMSO): = 8.875(8.9); 8.871(9.5); 8.645(2.2); 8.632(4.5); 8.610(8.4); 8.604(8.8); 8.243(9.1); 7.783(4.7); 7.766(16.0); 7.746(13.6); 7.730(2.6); 7.711(5.8); 7.692(4.2); 7.653(4.1); 7.634(5.3); 7.615(2.2); 7.505(0.5); 7.485(0.5); 7.450(5.8); 7.431(5.5); 7.420(13.0); 7.399(11.7); 7.239(0.6); 7.218(0.6); 3.523(2.9); 3.506(6.8); 3.491(6.9); 3.473(3.5); 3.339(1435.4); 2.995(3.2); 2.903(5.8); 2.885(10.0); 2.867(5.2); 2.789(0.6); 2.712(0.7); 2.671(2.8); 2.542(99.7); 2.502(401.4); 2.368(0.4); 2.329(2.5); 1.235(1.4); 0.000(1.4) Example 1-54: .sup.1H-NMR(400.0 MHz, DMSO): = 8.635(0.9); 8.622(1.7); 8.608(0.9); 8.449(2.7); 8.443(2.8); 7.982(1.5); 7.976(1.5); 7.960(1.5); 7.954(1.6); 7.782(1.7); 7.762(2.2); 7.727(0.8); 7.708(1.9); 7.689(1.4); 7.651(1.4); 7.632(1.8); 7.608(4.0); 7.588(4.4); 7.451(2.0); 7.433(1.8); 7.356(4.1); 7.336(3.6); 6.826(2.6); 6.805(2.5); 5.315(0.5); 5.299(1.2); 5.284(1.6); 5.268(1.2); 5.253(0.5); 3.506(1.0); 3.490(2.3); 3.473(2.3); 3.456(1.1); 3.341(233.6); 2.872(1.9); 2.854(3.2); 2.836(1.7); 2.672(0.5); 2.542(0.9); 2.503(66.4); 2.329(0.4); 1.320(16.0); 1.305(15.8) Example 1-55: .sup.1H-NMR(400.0 MHz, DMSO): = 8.641(2.4); 8.627(4.9); 8.613(2.5); 8.588(0.4); 8.573(0.6); 8.029(14.1); 8.008(16.0); 7.995(4.2); 7.993(5.5); 7.976(10.5); 7.974(11.1); 7.954(9.8); 7.945(0.6); 7.934(12.5); 7.915(5.3); 7.781(5.4); 7.761(7.0); 7.727(2.5); 7.709(6.3); 7.691(4.5); 7.651(4.6); 7.632(5.9); 7.614(2.2); 7.506(2.0); 7.490(0.7); 7.485(2.4); 7.479(0.4); 7.463(8.5); 7.461(9.7); 7.448(6.7); 7.444(10.1); 7.442(9.5); 7.430(6.0); 7.420(15.7); 7.399(14.3); 7.240(2.1); 7.219(1.9); 3.855(0.3); 3.839(0.3); 3.776(0.4); 3.711(0.5); 3.681(0.6); 3.665(0.7); 3.605(1.0); 3.589(1.1); 3.529(5.2); 3.512(9.3); 3.496(9.5); 3.478(7.5); 3.391(1226.2); 3.388(1172.8); 3.382(1096.2); 3.376(1340.9); 3.138(0.6); 3.098(0.5); 3.092(0.5); 3.049(0.5); 3.032(0.4); 2.996(8.1); 2.959(0.3); 2.907(6.1); 2.889(10.6); 2.871(5.5); 2.809(1.0); 2.790(1.7); 2.772(0.9); 2.714(2.0); 2.679(2.1); 2.674(2.8); 2.670(2.1); 2.665(1.0); 2.596(0.4); 2.592(0.5); 2.582(0.6); 2.579(0.6); 2.573(0.6); 2.564(1.6); 2.561(2.0); 2.544(540.2); 2.5342(2.9); 2.5335(2.8); 2.533(2.8); 2.532(2.8); 2.528(6.7); 2.523(10.7); 2.514(151.1); 2.510(305.9); 2.505(403.7); 2.500(291.2); 2.496(136.5); 2.442(0.5); 2.370(2.0); 2.341(1.0); 2.336(2.0); 2.332(2.7); 2.327(2.0); 2.323(1.0); 2.073(0.3); 1.234(0.9); 0.000(9.0) Example 1-56: .sup.1H-NMR(400.0 MHz, DMSO): = 20.012(0.9); 8.639(3.3); 8.435(3.7); 8.430(4.1); 8.423(4.1); 8.418(4.1); 7.880(3.6); 7.876(3.8); 7.861(4.4); 7.857(4.3); 7.782(3.5); 7.763(4.6); 7.721(1.5); 7.702(3.9); 7.684(2.9); 7.652(2.9); 7.633(3.6); 7.615(1.4); 7.540(4.1); 7.528(4.0); 7.521(4.0); 7.509(3.6); 7.455(6.4); 7.435(16.0); 7.420(4.2); 7.397(12.5); 7.377(6.4); 3.541(2.4); 3.524(4.9); 3.509(4.8); 3.491(2.7); 3.338(4723.8); 2.995(1.7); 2.913(4.6); 2.894(7.5); 2.876(4.1); 2.671(9.2); 2.541(23.6); 2.507(1043.0); 2.502(1330.7); 2.498(995.1); 2.329(8.5); 2.290(0.7); 1.298(1.0); 1.236(7.9); 0.854(1.1); 0.000(6.6) Example 1-57: .sup.1H-NMR(400.0 MHz, DMSO): = 8.896(9.6); 8.892(9.3); 8.651(2.9); 8.637(5.6); 8.624(3.0); 8.568(6.8); 8.557(7.0); 8.083(5.2); 8.063(5.6); 7.789(6.3); 7.769(8.3); 7.735(2.7); 7.716(7.7); 7.704(15.4); 7.684(16.0); 7.658(5.1); 7.639(6.6); 7.620(2.6); 7.500(4.9); 7.488(5.2); 7.481(5.0); 7.468(5.4); 7.460(7.8); 7.441(6.6); 7.416(15.6); 7.396(13.4); 3.529(3.8); 3.512(8.8); 3.496(8.9); 3.479(4.2); 3.445(0.6); 3.350(782.1); 3.001(1.4); 2.904(7.1); 2.885(12.5); 2.867(6.4); 2.718(0.6); 2.677(1.5); 2.547(84.8); 2.511(202.3); 2.508(213.2); 2.374(0.5); 2.335(1.4); 1.240(0.6); 1.075(0.4) Example 1-58: .sup.1H-NMR(400.0 MHz, DMSO): = 8.639(2.2); 8.625(4.4); 8.611(2.2); 8.510(7.3); 8.504(7.5); 8.123(4.1); 8.117(4.0); 8.101(4.3); 8.095(4.3); 7.782(4.4); 7.762(5.8); 7.727(1.9); 7.709(4.9); 7.690(3.5); 7.651(13.5); 7.631(16.0); 7.614(1.9); 7.452(5.2); 7.433(4.6); 7.380(11.1); 7.360(9.8); 7.087(7.1); 7.065(7.0); 5.075(3.3); 5.052(10.3); 5.029(10.6); 5.007(3.7); 3.512(2.5); 3.495(5.7); 3.478(5.8); 3.462(2.8); 3.385(0.5); 3.334(412.2); 2.996(2.3); 2.882(4.8); 2.864(8.2); 2.846(4.4); 2.711(0.6); 2.671(1.1); 2.541(107.5); 2.502(163.0); 2.368(0.6); 2.329(1.1); 1.234(0.5); 0.000(2.3) Example 1-59: .sup.1H-NMR(400.0 MHz, DMSO): = 8.621(0.8); 8.608(1.5); 8.594(0.8); 7.780(1.6); 7.760(2.1); 7.723(0.7); 7.705(1.8); 7.687(1.3); 7.650(1.3); 7.631(1.7); 7.612(0.6); 7.562(3.1); 7.557(3.3); 7.446(1.9); 7.427(1.7); 7.399(3.2); 7.378(5.2); 7.310(4.8); 7.290(3.2); 6.687(3.2); 6.683(3.3); 3.496(1.1); 3.479(2.3); 3.461(2.3); 3.445(1.3); 3.429(0.5); 3.356(426.6); 3.352(221.4); 3.270(0.3); 2.995(1.0); 2.849(1.9); 2.830(3.2); 2.812(1.7); 2.672(0.5); 2.668(0.4); 2.542(46.5); 2.507(58.1); 2.503(74.9); 2.499(59.0); 2.422(16.0); 2.400(0.3); 2.330(0.5); 2.326(0.4); 0.000(0.4) Example 1-60: .sup.1H-NMR(400.0 MHz, DMSO): = 8.608(0.8); 8.595(1.5); 8.581(0.8); 8.093(4.8); 7.823(4.9); 7.779(1.7); 7.759(2.2); 7.722(0.7); 7.702(1.9); 7.684(1.4); 7.648(1.4); 7.629(1.7); 7.610(0.7); 7.504(3.9); 7.484(4.6); 7.441(2.0); 7.422(1.8); 7.243(4.3); 7.223(3.7); 3.852(16.0); 3.475(1.0); 3.458(2.3); 3.441(2.3); 3.424(1.2); 3.394(0.5); 3.339(362.8); 2.995(1.8); 2.814(1.9); 2.795(3.2); 2.777(1.7); 2.712(0.5); 2.671(0.7); 2.542(103.1); 2.506(80.0); 2.502(100.7); 2.498(78.5); 2.368(0.5); 2.329(0.7); 0.000(0.8) Example 1-61: .sup.1H-NMR(400.0 MHz, DMSO): = 20.011(0.4); 8.622(1.5); 8.452(1.8); 8.445(1.8); 8.440(1.8); 7.780(1.5); 7.760(2.1); 7.720(0.7); 7.703(1.8); 7.686(1.2); 7.651(1.3); 7.632(1.7); 7.614(0.7); 7.592(1.7); 7.577(1.8); 7.573(1.9); 7.438(1.9); 7.419(1.6); 7.378(1.1); 7.357(8.3); 7.350(9.4); 7.329(1.4); 7.308(1.4); 7.298(1.5); 7.290(1.5); 7.278(1.3); 3.545(1.1); 3.527(2.3); 3.510(2.3); 3.494(1.2); 3.458(0.7); 3.337(2730.0); 2.995(1.2); 2.904(2.1); 2.886(3.5); 2.867(1.9); 2.671(5.6); 2.667(4.4); 2.541(25.2); 2.537(8.6); 2.506(638.8); 2.502(833.1); 2.498(660.0); 2.437(16.0); 2.329(5.4); 2.324(4.3); 2.290(0.5); 1.297(0.4); 1.235(2.3); 0.000(4.3) Example 1-62: .sup.1H-NMR(400.0 MHz, DMSO): = 8.647(2.6); 8.634(5.1); 8.620(2.7); 8.551(7.9); 8.547(8.0); 8.308(2.4); 8.302(2.4); 8.288(4.7); 8.282(4.5); 8.267(2.7); 8.261(2.5); 7.788(5.4); 7.769(7.2); 7.734(2.3); 7.716(6.2); 7.694(16.0); 7.674(14.8); 7.659(4.8); 7.639(5.7); 7.620(2.2); 7.457(6.4); 7.439(5.7); 7.410(14.0); 7.390(12.2); 7.296(4.7); 7.289(4.8); 7.275(4.6); 7.268(4.5); 3.524(3.2); 3.507(7.5); 3.491(7.7); 3.474(3.7); 3.414(1.1); 3.346(1160.7); 3.270(1.0); 3.201(0.3); 3.001(1.9); 2.899(6.2); 2.881(10.9); 2.863(5.6); 2.718(0.5); 2.677(2.3); 2.547(84.3); 2.512(298.0); 2.508(351.2); 2.374(0.5); 2.335(2.3); 1.813(2.3); 1.793(3.9); 1.760(3.5); 1.669(1.6); 1.304(1.6); 1.275(3.0); 1.245(3.8); 1.221(3.7); 1.198(2.1); 0.005(0.6) Example 1-63: .sup.1H-NMR(400.0 MHz, DMSO): = 8.618(0.7); 8.605(1.5); 8.591(0.8); 7.776(1.6); 7.757(2.1); 7.718(0.7); 7.700(1.8); 7.682(1.3); 7.648(1.3); 7.629(1.6); 7.611(0.7); 7.434(1.9); 7.415(1.7); 7.396(2.2); 7.375(5.9); 7.351(5.6); 7.330(2.4); 3.512(0.9); 3.495(2.2); 3.479(2.3); 3.462(1.1); 3.335(442.3); 2.995(2.0); 2.870(1.9); 2.852(3.3); 2.834(1.7); 2.671(1.2); 2.612(14.6); 2.541(39.3); 2.502(166.3); 2.371(16.0); 2.329(1.1); 1.235(0.5); 0.000(1.8) Example 1-64: .sup.1H-NMR(400.0 MHz, DMSO): = 8.795(0.6); 8.782(0.6); 8.640(2.9); 8.627(5.1); 8.613(2.7); 8.583(0.7); 8.569(1.2); 8.555(1.0); 8.489(0.8); 8.458(8.9); 8.445(9.3); 8.345(0.9); 8.253(0.5); 8.238(0.5); 7.979(0.9); 7.969(0.4); 7.959(1.0); 7.854(12.5); 7.837(13.1); 7.817(14.5); 7.780(6.1); 7.764(10.2); 7.757(10.1); 7.726(2.9); 7.707(7.1); 7.688(5.1); 7.650(5.0); 7.632(6.5); 7.613(2.5); 7.505(2.3); 7.485(2.7); 7.470(1.1); 7.437(16.0); 7.417(13.7); 7.238(2.6); 7.217(2.3); 3.526(3.7); 3.509(8.0); 3.494(7.8); 3.476(3.7); 3.453(1.7); 3.437(1.7); 3.420(0.9); 3.330(716.8); 3.254(0.4); 2.995(0.4); 2.933(0.6); 2.911(6.6); 2.892(11.2); 2.875(5.5); 2.807(1.2); 2.789(2.2); 2.771(1.1); 2.671(2.7); 2.541(26.7); 2.502(405.0); 2.328(2.6); 1.299(0.3); 1.258(0.5); 1.235(1.4); 0.000(6.1) Example 1-65: .sup.1H-NMR(400.0 MHz, DMSO): = 8.724(0.3); 8.679(3.5); 8.665(6.9); 8.651(3.4); 8.618(0.4); 8.605(0.4); 8.480(13.0); 8.467(13.6); 8.317(1.0); 8.055(0.4); 8.051(0.5); 8.004(15.5); 7.999(16.0); 7.936(15.2); 7.933(15.6); 7.882(0.3); 7.842(7.5); 7.838(7.1); 7.820(14.6); 7.817(14.6); 7.807(9.4); 7.803(8.8); 7.783(7.5); 7.764(9.7); 7.734(3.2); 7.716(8.2); 7.697(5.8); 7.656(5.8); 7.637(7.5); 7.618(3.0); 7.590(0.4); 7.570(0.4); 7.543(13.1); 7.523(11.6); 7.475(8.5); 7.457(7.4); 6.896(0.4); 5.757(15.7); 3.556(4.1); 3.539(9.9); 3.524(10.2); 3.507(4.6); 3.326(311.2); 3.285(0.4); 3.032(8.3); 3.014(14.9); 2.997(7.2); 2.676(1.7); 2.671(2.3); 2.667(1.7); 2.524(7.0); 2.511(127.9); 2.507(249.7); 2.502(325.9); 2.498(238.1); 2.493(116.4); 2.333(1.5); 2.329(2.1); 2.325(1.5); 1.989(0.4); 1.422(1.3); 1.414(1.6); 1.407(1.9); 1.398(0.6); 1.351(3.4); 1.336(2.0); 1.313(0.4); 1.298(2.0); 1.259(3.2); 1.250(3.6); 1.234(7.7); 1.193(0.6); 1.187(0.7); 1.175(0.7); 1.157(0.5); 1.105(0.4); 0.868(0.8); 0.853(1.4); 0.834(1.0); 0.812(0.7); 0.755(0.3); 0.008(1.9); 0.000(48.0); 0.008(1.7) Example 1-66: .sup.1H-NMR(400.0 MHz, DMSO): = 8.785(12.6); 8.779(12.9); 8.681(3.5); 8.667(7.1); 8.653(3.5); 8.313(0.6); 8.226(8.4); 8.219(8.1); 8.205(9.0); 8.198(8.9); 7.882(15.5); 7.877(16.0); 7.784(7.3); 7.765(9.7); 7.735(3.3); 7.723(8.6); 7.718(14.1); 7.703(10.4); 7.698(14.2); 7.658(5.8); 7.638(7.6); 7.624(14.5); 7.603(12.5); 7.521(13.5); 7.501(11.3); 7.480(8.6); 7.462(7.4); 5.754(2.7); 3.549(4.5); 3.532(10.0); 3.516(10.1); 3.499(5.0); 3.468(0.9); 3.451(1.1); 3.357(1210.0); 3.269(0.8); 3.259(0.6); 3.021(8.3); 3.003(14.4); 2.985(7.2); 2.944(0.3); 2.678(1.0); 2.674(1.3); 2.669(0.9); 2.527(4.2); 2.513(72.8); 2.509(140.2); 2.505(181.5); 2.500(132.9); 2.496(65.3); 2.336(0.9); 2.331(1.2); 2.327(0.8); 1.352(0.6); 1.299(0.4); 1.259(0.7); 1.250(0.5); 1.233(1.9); 0.008(0.9); 0.000(21.0); 0.008(0.8) Example 1-67: 1H-NMR(400.0 MHz, DMSO): = 9.208(2.6); 9.192(5.7); 9.177(2.6); 8.844(9.6); 8.838(9.6); 8.795(5.5); 8.783(5.4); 8.317(3.1); 8.289(6.5); 8.283(6.3); 8.268(6.9); 8.262(7.0); 8.058(9.2); 8.054(10.1); 7.902(4.3); 7.898(4.2); 7.881(5.9); 7.877(6.2); 7.871(4.5); 7.868(4.6); 7.851(6.4); 7.848(6.5); 7.786(6.0); 7.774(16.0); 7.766(4.5); 7.754(11.2); 7.673(10.3); 7.652(9.7); 4.288(2.2); 4.272(2.3); 4.252(5.1); 4.236(5.0); 4.215(2.6); 4.200(2.5); 4.038(0.9); 4.020(0.9); 3.374(0.4); 3.327(896.8); 3.304(2.4); 3.290(0.6); 2.680(1.2); 2.676(2.7); 2.671(3.8); 2.667(2.8); 2.525(7.6); 2.520(11.6); 2.511(197.0); 2.507(417.4); 2.502(564.0); 2.498(413.1); 2.493(201.7); 2.333(2.6); 2.329(3.7); 2.324(2.8); 2.320(1.3); 1.989(3.8); 1.259(0.4); 1.234(0.7); 1.193(1.1); 1.175(2.1); 1.157(1.0); 0.000(2.4) Example 1-68: 1H-NMR(400.0 MHz, DMSO): = 9.045(2.7); 9.029(6.0); 9.014(2.8); 8.842(10.2); 8.836(10.2); 8.317(0.4); 8.287(6.9); 8.280(6.7); 8.266(7.4); 8.259(7.5); 8.049(10.0); 8.045(10.8); 7.900(4.5); 7.896(4.5); 7.879(6.3); 7.875(6.4); 7.771(16.0); 7.750(15.6); 7.726(2.4); 7.709(6.2); 7.690(4.6); 7.668(10.9); 7.657(5.0); 7.647(10.7); 7.638(5.8); 7.619(2.0); 7.388(6.5); 7.370(5.9); 4.264(2.4); 4.248(2.5); 4.228(5.5); 4.212(5.3); 4.192(2.8); 4.176(2.6); 4.056(0.4); 4.038(1.2); 4.020(1.2); 4.003(0.4); 3.330(170.1); 2.676(0.6); 2.672(0.8); 2.668(0.6); 2.525(1.9); 2.520(2.9); 2.512(43.4); 2.507(89.9); 2.503(119.7); 2.498(87.4); 2.494(42.5); 2.334(0.5); 2.330(0.7); 2.325(0.6); 1.990(5.4); 1.397(3.7); 1.234(1.0); 1.193(1.5); 1.175(2.9); 1.158(1.4); 0.000(0.6) Example 1-69: 1H-NMR(400.0 MHz, DMSO): = 9.381(13.2); 9.039(3.0); 9.024(6.1); 9.008(2.9); 8.316(1.3); 8.306(16.0); 8.207(9.7); 8.203(10.2); 8.059(4.9); 8.054(4.6); 8.037(5.9); 8.032(5.6); 7.832(10.0); 7.810(8.4); 7.764(5.9); 7.745(8.0); 7.722(2.6); 7.703(6.7); 7.685(4.9); 7.653(5.0); 7.634(5.9); 7.616(2.1); 7.598(0.4); 7.582(0.4); 7.578(0.4); 7.488(0.5); 7.389(6.9); 7.370(6.1); 7.016(0.5); 6.995(0.5); 6.919(0.5); 5.757(1.5); 4.255(2.6); 4.240(2.8); 4.220(5.8); 4.204(5.6); 4.184(3.0); 4.169(2.7); 3.329(217.7); 2.676(1.0); 2.672(1.4); 2.507(152.3); 2.503(195.0); 2.499(147.9); 2.329(1.2); 1.989(0.5); 1.234(0.5); 0.000(15.4) Example 1-70: 1H-NMR (400.0 MHz, CD3CN): = 9.027 (8.8); 9.022 (8.9); 8.263 (4.8); 8.258 (4.9); 8.243 (5.3); 8.238 (5.5); 7.895 (10.5); 7.875 (9.6); 7.861 (12.4); 7.790 (4.5); 7.786 (3.9); 7.770 (10.2); 7.766 (13.5); 7.744 (8.3); 7.736 (16.0); 7.716 (7.1); 7.692 (2.4); 7.674 (6.7); 7.656 (5.4); 7.630 (5.0); 7.612 (6.0); 7.593 (2.3); 7.487 (7.3); 7.468 (6.0); 7.211 (2.9); 6.146 (2.5); 6.138 (2.7); 6.129 (2.8); 6.121 (2.6); 6.029 (2.5); 6.021 (2.7); 6.012 (2.9); 6.004 (2.6); 5.447 (0.3); 4.031 (1.2); 4.022 (1.3); 4.015 (1.3); 4.007 (1.3); 3.994 (2.0); 3.986 (2.1); 3.979 (2.0); 3.971 (2.0); 3.962 (1.4); 3.954 (1.2); 3.947 (1.4); 3.938 (1.3); 3.925 (2.1); 3.917 (2.1); 3.910 (2.2); 3.902 (2.0); 3.885 (1.9); 3.869 (2.9); 3.851 (2.3); 3.830 (3.5); 3.814 (4.0); 3.796 (2.2); 3.777 (1.8); 3.760 (1.2); 2.473 (0.5); 2.468 (1.0); 2.463 (1.3); 2.458 (1.0); 2.453 (0.5); 2.156 (318.6); 2.120 (1.6); 2.114 (1.9); 2.107 (2.4); 2.101 (1.6); 2.095 (0.9); 1.964 (10.5); 1.958 (26.6); 1.952 (141.2); 1.946 (254.9); 1.940 (341.3); 1.934 (238.2); 1.928 (125.4); 1.781 (0.9); 1.775 (1.5); 1.768 (2.0); 1.762 (1.4); 1.756 (0.8); 1.437 (0.5); 1.372 (0.4); 1.340 (0.6); 1.285 (1.0); 1.270 (3.0); 0.900 (0.4); 0.881 (0.6); 0.858 (0.5); 0.842 (0.4); 0.146 (2.7); 0.008 (22.3); 0.000 (585.7); 0.009 (27.3); 0.150 (2.7) Example 1-76: 1H-NMR (400.0 MHz, d6-DMSO): = 10.327 (0.5); 9.028 (0.4); 9.011 (0.5); 8.505 (0.4); 8.488 (0.4); 4.056 (1.3); 4.038 (3.7); 4.020 (3.8); 4.002 (1.3); 3.888 (0.3); 3.869 (0.4); 3.851 (0.4); 3.531 (0.3); 3.503 (0.3); 3.449 (0.3); 3.432 (0.3); 3.173 (0.5); 2.515 (5.2); 2.511 (10.7); 2.506 (14.5); 2.502 (11.1); 2.498 (5.7); 1.989 (16.0); 1.910 (7.9); 1.212 (0.6); 1.200 (0.4); 1.193 (4.9); 1.183 (0.7); 1.175 (8.9); 1.165 (0.4); 1.158 (4.3); 1.073 (0.3); 1.056 (0.7); 1.038 (0.3); 0.000 (5.8) Example 1-71: 1H-NMR (400.0 MHz, CD3CN): = 9.029 (10.1); 9.024 (10.2); 8.759 (7.1); 8.747 (7.2); 8.279 (0.5); 8.265 (5.6); 8.260 (5.7); 8.244 (6.2); 8.240 (6.1); 7.897 (11.5); 7.876 (13.6); 7.868 (12.1); 7.864 (14.5); 7.854 (8.8); 7.793 (5.2); 7.789 (4.7); 7.773 (9.8); 7.769 (9.4); 7.730 (16.0); 7.710 (8.2); 7.673 (6.5); 7.662 (6.6); 7.654 (5.7); 7.642 (5.4); 7.589 (0.7); 7.492 (0.4); 7.480 (0.4); 7.461 (0.3); 7.331 (3.4); 6.149 (2.7); 6.140 (3.1); 6.131 (3.1); 6.123 (3.0); 6.032 (2.8); 6.023 (3.0); 6.014 (3.1); 6.006 (2.9); 5.823 (1.0); 5.706 (1.0); 5.417 (0.4); 4.067 (0.4); 4.049 (1.6); 4.041 (1.4); 4.034 (1.5); 4.025 (1.4); 4.012 (2.2); 4.004 (2.3); 3.997 (2.4); 3.989 (2.2); 3.980 (1.4); 3.972 (1.4); 3.965 (1.5); 3.957 (1.4); 3.943 (2.3); 3.935 (2.4); 3.928 (2.4); 3.920 (2.2); 3.897 (5.2); 3.881 (3.3); 3.865 (2.4); 3.843 (3.4); 3.826 (4.0); 3.809 (2.3); 3.789 (2.0); 3.772 (1.3); 3.361 (0.9); 3.170 (1.9); 2.711 (0.8); 2.693 (1.3); 2.675 (0.9); 2.467 (3.1); 2.463 (4.2); 2.458 (3.1); 2.158 (746.2); 2.120 (3.2); 2.114 (4.4); 2.107 (5.5); 2.101 (4.0); 2.095 (2.3); 2.071 (0.6); 2.049 (0.4); 1.964 (24.7); 1.958 (63.7); 1.952 (335.0); 1.946 (611.8); 1.940 (827.6); 1.934 (583.6); 1.928 (310.5); 1.806 (0.4); 1.781 (2.1); 1.775 (3.5); 1.768 (4.9); 1.762 (3.5); 1.756 (2.0); 1.705 (0.4); 1.687 (0.4); 1.669 (0.5); 1.652 (0.8); 1.634 (0.7); 1.615 (0.4); 1.559 (0.4); 1.539 (0.4); 1.372 (0.6); 1.359 (0.6); 1.339 (0.7); 1.277 (11.9); 1.229 (0.3); 1.222 (0.5); 1.204 (0.8); 1.186 (0.5); 0.899 (1.0); 0.882 (2.8); 0.864 (1.4); 0.841 (0.4); 0.146 (5.8); 0.008 (45.5); 0.000 (1261.0); 0.008 (66.5); 0.083 (0.4); 0.112 (0.3); 0.150 (5.9) Example 1-72: 1H-NMR (400.0 MHz, CD3CN): = 9.014 (6.8); 9.010 (6.8); 8.840 (16.0); 8.838 (15.9); 8.831 (4.0); 8.252 (3.7); 8.247 (3.7); 8.231 (4.1); 8.227 (4.1); 7.927 (2.3); 7.894 (7.8); 7.873 (6.9); 7.854 (9.3); 7.759 (2.6); 7.755 (2.2); 7.739 (7.7); 7.735 (7.5); 7.719 (11.9); 7.699 (3.7); 6.172 (1.8); 6.164 (2.0); 6.154 (2.1); 6.146 (1.9); 6.055 (1.9); 6.047 (2.0); 6.037 (2.1); 6.028 (1.9); 5.448 (1.4); 4.084 (0.9); 4.075 (0.9); 4.068 (1.0); 4.060 (1.0); 4.047 (1.5); 4.039 (1.5); 4.032 (1.5); 4.023 (1.4); 4.014 (0.9); 4.006 (0.9); 3.999 (0.9); 3.990 (0.9); 3.977 (1.5); 3.969 (1.5); 3.962 (1.6); 3.954 (1.4); 3.938 (1.4); 3.921 (2.0); 3.904 (1.8); 3.886 (2.6); 3.868 (2.8); 3.851 (1.8); 3.832 (1.3); 3.815 (0.8); 2.469 (0.6); 2.464 (0.9); 2.459 (0.7); 2.455 (0.4); 2.159 (498.2); 2.120 (1.2); 2.114 (1.5); 2.108 (1.8); 2.102 (1.2); 2.095 (0.7); 1.964 (8.6); 1.958 (22.7); 1.953 (104.3); 1.947 (185.7); 1.940 (245.6); 1.934 (171.7); 1.928 (90.2); 1.781 (0.6); 1.775 (1.1); 1.769 (1.5); 1.763 (1.1); 1.756 (0.6); 1.673 (0.3); 1.437 (1.4); 1.299 (0.3); 1.271 (1.7); 1.204 (0.3); 0.881 (0.5); 0.146 (1.6); 0.000 (346.7); 0.008 (18.6); 0.150 (1.7) Example 1-75: 1H-NMR (400.0 MHz, d6-DMSO): = 9.007 (3.5); 8.992 (7.0); 8.978 (3.5); 8.489 (7.2); 8.485 (7.9); 8.478 (7.8); 8.473 (7.8); 8.316 (0.3); 7.955 (7.2); 7.951 (7.6); 7.936 (8.2); 7.932 (8.1); 7.797 (7.1); 7.778 (9.4); 7.748 (3.1); 7.730 (8.2); 7.719 (10.5); 7.712 (6.8); 7.699 (14.2); 7.688 (14.7); 7.675 (6.2); 7.656 (7.2); 7.637 (2.7); 7.610 (8.5); 7.606 (8.1); 7.590 (6.2); 7.586 (6.2); 7.576 (7.8); 7.564 (7.6); 7.557 (7.4); 7.545 (6.9); 7.497 (8.4); 7.478 (7.2); 6.097 (2.2); 6.087 (2.5); 6.079 (2.9); 6.069 (2.3); 5.979 (2.3); 5.963 (3.4); 5.951 (2.3); 5.756 (8.9); 4.056 (1.3); 4.038 (3.8); 4.020 (3.9); 4.003 (1.3); 3.886 (0.4); 3.875 (0.7); 3.862 (0.7); 3.850 (2.2); 3.836 (4.2); 3.827 (2.7); 3.819 (3.4); 3.802 (2.3); 3.782 (4.8); 3.767 (6.3); 3.751 (2.5); 3.730 (0.4); 3.568 (2.5); 3.324 (66.3); 2.675 (0.6); 2.671 (0.8); 2.506 (103.6); 2.502 (135.1); 2.498 (104.9); 2.329 (0.9); 2.325 (0.7); 1.989 (16.0); 1.397 (4.4); 1.299 (0.6); 1.259 (1.0); 1.235 (4.0); 1.193 (4.4); 1.175 (8.5); 1.158 (4.3); 0.868 (0.3); 0.853 (0.6); 0.836 (0.4); 0.000 (33.9) Example 1-74: 1H-NMR (400.0 MHz, d6-DMSO): = 9.920 (0.5); 8.985 (3.8); 8.971 (7.9); 8.957 (4.0); 8.646 (11.1); 8.640 (11.8); 8.406 (3.8); 8.400 (3.8); 8.386 (6.5); 8.379 (6.4); 8.365 (4.1); 8.359 (4.0); 8.316 (0.5); 7.943 (15.3); 7.848 (6.8); 7.844 (6.5); 7.828 (9.1); 7.824 (9.0); 7.795 (7.9); 7.776 (10.5); 7.753 (3.5); 7.734 (8.8); 7.709 (16.0); 7.689 (11.7); 7.674 (6.6); 7.654 (8.0); 7.635 (3.1); 7.502 (9.3); 7.483 (8.1); 7.336 (7.0); 7.329 (7.2); 7.315 (7.0); 7.308 (6.9); 6.082 (2.5); 6.073 (2.8); 6.064 (3.2); 6.055 (2.7); 5.964 (2.5); 5.953 (2.9); 5.948 (3.6); 5.937 (2.6); 4.038 (0.7); 4.020 (0.8); 3.868 (0.6); 3.858 (0.8); 3.855 (0.8); 3.844 (0.9); 3.832 (2.3); 3.819 (3.1); 3.811 (3.4); 3.796 (3.4); 3.778 (2.7); 3.760 (4.4); 3.752 (4.7); 3.744 (5.8); 3.728 (2.5); 3.708 (0.6); 3.692 (0.5); 3.325 (125.0); 2.676 (0.9); 2.672 (1.2); 2.667 (0.9); 2.507 (147.4); 2.502 (193.9); 2.498 (148.1); 2.334 (0.9); 2.329 (1.3); 2.325 (1.0); 1.989 (3.2); 1.398 (2.3); 1.234 (0.9); 1.193 (0.9); 1.175 (1.7); 1.157 (0.8); 0.008 (1.9); 0.000 (47.2) Example 1-73: 1H-NMR (400.0 MHz, d6-DMSO): = 10.221 (0.4); 8.985 (1.7); 8.971 (3.5); 8.956 (1.7); 8.824 (6.0); 8.818 (6.1); 8.267 (4.0); 8.261 (3.9); 8.246 (4.3); 8.240 (4.4); 7.968 (6.6); 7.923 (0.4); 7.917 (0.4); 7.869 (3.1); 7.865 (2.9); 7.849 (4.0); 7.845 (3.9); 7.820 (0.3); 7.795 (3.4); 7.775 (4.5); 7.751 (1.5); 7.734 (3.8); 7.717 (8.9); 7.696 (5.3); 7.673 (2.8); 7.654 (9.7); 7.633 (7.1); 7.535 (0.3); 7.514 (0.4); 7.500 (4.0); 7.481 (3.5); 7.287 (0.5); 7.250 (0.4); 7.242 (0.4); 6.083 (1.1); 6.074 (1.2); 6.065 (1.4); 6.056 (1.1); 5.965 (1.1); 5.955 (1.2); 5.949 (1.5); 5.938 (1.1); 4.056 (1.2); 4.038 (3.6); 4.020 (3.6); 4.003 (1.2); 3.858 (0.4); 3.855 (0.4); 3.845 (0.4); 3.832 (1.0); 3.822 (1.3); 3.810 (1.6); 3.795 (1.5); 3.777 (1.3); 3.764 (1.5); 3.758 (2.0); 3.754 (2.0); 3.742 (2.5); 3.727 (1.0); 3.707 (0.4); 3.569 (1.8); 3.326 (42.7); 2.676 (0.4); 2.672 (0.6); 2.667 (0.5); 2.525 (1.5); 2.511 (33.5); 2.507 (69.2); 2.503 (92.7); 2.498 (69.3); 2.494 (35.3); 2.334 (0.4); 2.329 (0.6); 2.325 (0.5); 1.989 (16.0); 1.397 (0.4); 1.234 (0.8); 1.193 (4.3); 1.175 (8.5); 1.158 (4.2); 0.008 (1.1); 0.000 (33.3); 0.008 (1.4) Example 1-77: 1H-NMR (400.0 MHz, d6-DMSO): = 10.453 (1.6); 8.990 (2.9); 8.975 (5.8); 8.961 (3.0); 8.948 (13.8); 8.943 (14.0); 8.797 (0.7); 8.794 (0.8); 8.678 (12.8); 8.672 (13.3); 8.637 (0.6); 8.631 (0.6); 8.548 (2.0); 8.377 (8.8); 8.371 (15.2); 8.366 (8.5); 8.316 (0.7); 8.141 (0.4); 8.138 (0.4); 8.135 (0.4); 8.131 (0.4); 8.102 (0.9); 8.096 (0.9); 8.072 (0.9); 8.067 (0.9); 8.027 (11.3); 7.922 (5.6); 7.918 (5.2); 7.902 (6.8); 7.897 (6.6); 7.795 (5.8); 7.776 (7.7); 7.753 (2.5); 7.735 (6.5); 7.717 (16.0); 7.697 (9.8); 7.674 (4.6); 7.655 (5.8); 7.636 (2.2); 7.501 (6.9); 7.483 (5.9); 7.333 (1.0); 7.270 (0.7); 7.264 (1.1); 7.258 (0.6); 6.529 (0.5); 6.087 (1.9); 6.078 (2.1); 6.069 (2.4); 6.060 (1.9); 5.969 (1.9); 5.958 (2.1); 5.953 (2.6); 5.942 (1.9); 5.756 (5.9); 3.872 (0.5); 3.862 (0.6); 3.858 (0.6); 3.848 (0.6); 3.836 (1.8); 3.826 (2.2); 3.822 (2.1); 3.814 (2.5); 3.799 (2.4); 3.781 (2.0); 3.768 (2.5); 3.762 (3.2); 3.757 (3.2); 3.746 (4.3); 3.731 (1.8); 3.710 (0.4); 3.324 (116.6); 2.680 (0.4); 2.676 (0.9); 2.671 (1.3); 2.667 (1.0); 2.662 (0.5); 2.525 (3.0); 2.520 (4.8); 2.511 (71.5); 2.507 (148.6); 2.502 (199.1); 2.498 (144.4); 2.493 (69.6); 2.338 (0.4); 2.334 (0.9); 2.329 (1.3); 2.325 (0.9); 1.989 (0.5); 1.259 (0.4); 1.234 (0.8); 0.857 (0.5); 0.839 (0.8); 0.000 (0.7) Example 1-78: 1H-NMR (400.0 MHz, d6-DMSO): = 8.984 (2.4); 8.969 (4.8); 8.955 (2.4); 8.350 (8.5); 8.336 (9.1); 8.316 (0.5); 8.074 (9.4); 7.982 (4.7); 7.977 (4.4); 7.961 (5.5); 7.957 (5.4); 7.930 (1.8); 7.915 (1.8); 7.803 (3.4); 7.798 (6.2); 7.794 (7.9); 7.791 (7.0); 7.786 (5.8); 7.781 (3.8); 7.773 (6.7); 7.750 (2.4); 7.742 (9.8); 7.733 (5.9); 7.722 (8.7); 7.714 (4.3); 7.672 (4.0); 7.654 (14.8); 7.634 (1.9); 7.495 (5.8); 7.477 (5.0); 6.733 (0.6); 6.728 (1.0); 6.724 (0.7); 6.718 (0.6); 6.714 (1.0); 6.709 (0.6); 6.405 (1.7); 6.400 (1.8); 6.094 (1.6); 6.085 (1.7); 6.077 (2.0); 6.067 (1.6); 5.976 (1.6); 5.966 (1.8); 5.960 (2.2); 5.949 (1.6); 5.756 (16.0); 4.331 (0.8); 4.038 (0.4); 4.020 (0.4); 3.877 (0.4); 3.868 (0.5); 3.864 (0.5); 3.854 (0.5); 3.841 (1.5); 3.831 (2.0); 3.828 (1.9); 3.821 (2.2); 3.805 (2.2); 3.788 (1.7); 3.774 (2.0); 3.768 (2.8); 3.764 (2.7); 3.752 (3.8); 3.737 (1.5); 3.716 (0.4); 3.701 (0.3); 3.325 (66.2); 2.676 (0.7); 2.672 (0.9); 2.667 (0.7); 2.525 (2.0); 2.520 (3.2); 2.511 (51.4); 2.507 (106.9); 2.503 (143.7); 2.498 (105.5); 2.494 (52.0); 2.334 (0.7); 2.329 (0.9); 2.325 (0.7); 1.989 (1.6); 1.398 (0.5); 1.259 (0.5); 1.234 (1.3); 1.193 (0.5); 1.175 (0.9); 1.158 (0.5); 0.000 (0.4) Example 1-80: 1H-NMR (400.0 MHz, d6-DMSO): = 9.180 (2.7); 9.165 (5.5); 9.151 (2.7); 8.813 (5.9); 8.803 (5.7); 8.801 (5.9); 8.491 (7.1); 8.486 (7.7); 8.479 (7.6); 8.474 (7.7); 8.316 (0.9); 7.973 (5.3); 7.955 (13.1); 7.950 (9.9); 7.936 (8.3); 7.931 (7.9); 7.806 (5.5); 7.795 (5.4); 7.787 (4.7); 7.775 (4.5); 7.721 (8.5); 7.701 (12.6); 7.696 (8.8); 7.693 (11.7); 7.612 (7.3); 7.608 (6.8); 7.592 (5.3); 7.588 (5.3); 7.578 (8.0); 7.566 (7.6); 7.559 (7.4); 7.547 (7.3); 6.097 (1.8); 6.089 (2.0); 6.079 (2.2); 6.070 (1.9); 5.979 (1.9); 5.970 (2.0); 5.962 (2.4); 5.952 (1.9); 5.756 (16.0); 4.056 (0.6); 4.038 (1.7); 4.020 (1.7); 4.002 (0.6); 3.923 (0.5); 3.915 (0.7); 3.910 (0.7); 3.900 (0.7); 3.887 (1.5); 3.878 (1.8); 3.874 (1.7); 3.865 (1.5); 3.855 (1.6); 3.839 (2.5); 3.830 (1.0); 3.817 (2.5); 3.803 (4.1); 3.793 (2.1); 3.786 (3.1); 3.769 (1.6); 3.750 (0.6); 3.733 (0.4); 3.323 (108.6); 2.680 (0.8); 2.676 (1.7); 2.671 (2.4); 2.667 (1.8); 2.662 (0.9); 2.525 (6.4); 2.520 (9.8); 2.511 (133.9); 2.507 (274.4); 2.502 (363.5); 2.498 (266.6); 2.493 (131.8); 2.338 (0.7); 2.333 (1.6); 2.329 (2.3); 2.324 (1.7); 2.086 (0.5); 1.989 (7.6); 1.398 (0.4); 1.298 (1.0); 1.259 (1.6); 1.235 (3.0); 1.193 (2.1); 1.175 (4.1); 1.157 (2.0); 0.854 (0.4); 0.146 (1.6); 0.008 (11.9); 0.000 (369.5); 0.008 (14.2); 0.150 (1.6) Example 1-79: 1H-NMR (400.0 MHz, d6-DMSO): = 9.353 (3.6); 9.339 (7.3); 9.324 (3.6); 9.044 (11.7); 9.038 (14.4); 8.986 (14.4); 8.980 (12.3); 8.491 (9.4); 8.486 (10.2); 8.479 (10.2); 8.474 (10.2); 8.316 (0.6); 7.952 (9.1); 7.947 (9.7); 7.933 (10.7); 7.928 (10.3); 7.728 (11.6); 7.708 (15.7); 7.695 (15.2); 7.599 (9.5); 7.595 (9.0); 7.578 (16.0); 7.566 (10.2); 7.559 (9.7); 7.547 (9.5); 7.524 (0.5); 6.109 (2.5); 6.101 (2.8); 6.089 (3.0); 6.081 (2.6); 5.990 (2.5); 5.981 (2.7); 5.971 (3.2); 5.962 (2.6); 4.056 (0.6); 4.038 (1.8); 4.020 (1.9); 4.003 (0.6); 3.965 (0.9); 3.956 (1.0); 3.950 (1.0); 3.942 (1.1); 3.928 (2.0); 3.920 (2.3); 3.915 (2.2); 3.906 (2.0); 3.890 (0.9); 3.883 (2.3); 3.876 (1.2); 3.868 (3.0); 3.854 (2.9); 3.847 (4.1); 3.840 (3.4); 3.832 (3.9); 3.819 (3.2); 3.800 (2.4); 3.783 (0.8); 3.780 (0.8); 3.764 (0.7); 3.324 (103.0); 2.681 (0.6); 2.676 (1.2); 2.672 (1.7); 2.667 (1.2); 2.525 (4.6); 2.520 (7.1); 2.512 (93.7); 2.507 (191.6); 2.503 (254.7); 2.498 (188.2); 2.494 (94.5); 2.339 (0.5); 2.334 (1.2); 2.329 (1.6); 2.325 (1.2); 1.989 (8.0); 1.398 (1.4); 1.299 (0.9); 1.259 (1.4); 1.235 (2.4); 1.193 (2.2); 1.175 (4.3); 1.158 (2.2); 0.854 (0.4); 0.146 (1.3); 0.008 (9.8); 0.000 (287.4); 0.008 (12.6); 0.150 (1.3) Example 1-88: 1H-NMR (400.0 MHz, CD3CN): = 8.758 (4.3); 8.748 (4.3); 8.746 (4.3); 8.499 (5.5); 8.492 (5.8); 8.195 (2.9); 8.188 (2.8); 8.174 (3.9); 8.168 (3.7); 8.167 (3.8); 8.154 (3.0); 8.147 (2.9); 7.873 (3.9); 7.871 (4.1); 7.854 (4.8); 7.852 (4.8); 7.773 (9.0); 7.708 (1.5); 7.704 (1.1); 7.687 (10.2); 7.683 (12.0); 7.680 (16.0); 7.673 (4.9); 7.661 (6.0); 7.653 (3.9); 7.641 (3.7); 7.301 (1.8); 7.151 (4.4); 7.144 (4.4); 7.130 (4.3); 7.123 (4.3); 6.131 (2.1); 6.123 (2.3); 6.113 (2.3); 6.105 (2.2); 6.014 (2.1); 6.006 (2.3); 5.996 (2.4); 5.988 (2.2); 5.448 (3.0); 4.038 (1.1); 4.029 (1.1); 4.022 (1.1); 4.014 (1.1); 4.001 (1.7); 3.993 (1.7); 3.986 (1.6); 3.978 (1.7); 3.969 (1.1); 3.960 (1.0); 3.953 (1.1); 3.945 (1.0); 3.932 (1.7); 3.924 (1.6); 3.917 (1.7); 3.908 (1.6); 3.882 (1.6); 3.866 (2.0); 3.864 (2.0); 3.849 (1.7); 3.845 (1.3); 3.827 (2.8); 3.812 (3.0); 3.794 (1.7); 3.790 (1.3); 3.775 (1.3); 3.773 (1.3); 3.757 (1.0); 2.467 (0.3); 2.462 (0.5); 2.458 (0.3); 2.153 (127.6); 2.120 (0.8); 2.114 (1.0); 2.108 (1.2); 2.102 (0.9); 2.096 (0.5); 1.972 (1.1); 1.965 (4.6); 1.959 (11.9); 1.953 (71.9); 1.947 (131.0); 1.940 (176.9); 1.934 (120.6); 1.928 (62.2); 1.915 (1.3); 1.781 (0.5); 1.775 (0.8); 1.769 (1.1); 1.763 (0.8); 1.756 (0.4); 1.340 (0.5); 1.285 (0.9); 1.269 (1.8); 1.222 (0.3); 1.204 (0.6); 1.186 (0.3); 0.881 (0.4); 0.000 (8.1) Example 1-87: 1H-NMR (400.0 MHz, CD3CN): = 8.846 (2.4); 8.837 (11.1); 8.830 (2.4); 8.485 (3.9); 8.480 (4.0); 8.183 (1.7); 8.176 (1.6); 8.162 (2.7); 8.156 (2.5); 8.142 (1.8); 8.136 (1.7); 7.926 (1.3); 7.764 (6.1); 7.683 (0.7); 7.663 (16.0); 7.640 (0.5); 7.148 (2.9); 7.141 (2.9); 7.126 (2.8); 7.119 (2.8); 6.155 (1.4); 6.147 (1.4); 6.136 (1.5); 6.128 (1.4); 6.037 (1.4); 6.029 (1.4); 6.019 (1.5); 6.011 (1.4); 5.448 (1.4); 4.071 (0.7); 4.063 (0.6); 4.055 (0.6); 4.048 (0.8); 4.034 (1.0); 4.026 (1.0); 4.019 (0.9); 4.011 (1.0); 4.001 (0.6); 3.993 (0.6); 3.986 (0.6); 3.977 (0.6); 3.964 (1.0); 3.956 (1.0); 3.949 (1.0); 3.941 (0.9); 3.923 (0.9); 3.905 (1.3); 3.888 (1.2); 3.870 (1.6); 3.853 (1.8); 3.836 (1.2); 3.817 (0.8); 3.800 (0.5); 2.469 (0.3); 2.465 (0.5); 2.460 (0.3); 2.167 (252.6); 2.121 (0.6); 2.114 (0.7); 2.108 (0.8); 2.102 (0.6); 2.096 (0.4); 1.972 (2.0); 1.965 (3.1); 1.959 (7.9); 1.953 (45.2); 1.947 (81.9); 1.941 (110.9); 1.935 (76.2); 1.929 (39.5); 1.776 (0.5); 1.769 (0.7); 1.763 (0.5); 1.340 (0.3); 1.285 (0.8); 1.270 (2.7); 1.222 (0.6); 1.204 (1.0); 1.186 (0.5); 0.881 (0.5); 0.858 (0.5); 0.000 (8.0) Example 1-86: 1H-NMR (400.0 MHz, CD3CN): = 8.757 (5.0); 8.747 (5.0); 8.745 (5.0); 8.678 (8.5); 8.672 (8.7); 8.050 (6.7); 8.043 (6.6); 8.029 (7.2); 8.022 (7.1); 7.870 (4.6); 7.867 (4.7); 7.850 (5.6); 7.848 (5.6); 7.786 (10.6); 7.721 (2.5); 7.717 (1.9); 7.700 (10.1); 7.696 (10.2); 7.688 (16.0); 7.671 (5.5); 7.660 (5.1); 7.652 (4.4); 7.640 (4.1); 7.521 (10.1); 7.500 (9.3); 7.306 (2.2); 6.130 (2.3); 6.122 (2.4); 6.113 (2.5); 6.105 (2.3); 6.013 (2.3); 6.005 (2.4); 5.996 (2.5); 5.988 (2.3); 5.448 (1.3); 4.068 (0.9); 4.050 (0.9); 4.036 (1.2); 4.028 (1.2); 4.021 (1.2); 4.013 (1.2); 4.000 (1.8); 3.992 (1.9); 3.985 (1.8); 3.976 (1.8); 3.968 (1.2); 3.960 (1.1); 3.952 (1.2); 3.944 (1.1); 3.931 (1.9); 3.923 (1.8); 3.916 (1.9); 3.908 (1.8); 3.882 (1.7); 3.866 (2.3); 3.849 (1.9); 3.845 (1.4); 3.827 (2.9); 3.811 (3.2); 3.793 (1.8); 3.790 (1.4); 3.774 (1.5); 3.757 (1.1); 2.467 (0.5); 2.462 (0.7); 2.458 (0.5); 2.157 (163.6); 2.120 (0.7); 2.114 (1.0); 2.108 (1.2); 2.102 (0.9); 2.096 (0.5); 1.972 (4.4); 1.965 (5.7); 1.959 (14.2); 1.953 (80.4); 1.947 (145.3); 1.941 (194.9); 1.934 (132.8); 1.928 (67.6); 1.781 (0.5); 1.775 (0.8); 1.769 (1.1); 1.763 (0.8); 1.757 (0.4); 1.285 (0.5); 1.270 (0.9); 1.222 (1.1); 1.204 (2.1); 1.186 (1.1); 0.000 (8.5) Example 1-85: 1H-NMR (400.0 MHz, CD3CN): = 8.844 (2.2); 8.836 (12.7); 8.829 (2.1); 8.665 (4.6); 8.659 (4.7); 8.038 (3.9); 8.031 (3.8); 8.017 (4.2); 8.010 (4.1); 7.897 (1.2); 7.779 (5.8); 7.776 (6.1); 7.674 (16.0); 7.671 (15.1); 7.517 (5.4); 7.516 (5.3); 7.497 (5.0); 7.495 (4.9); 6.154 (1.5); 6.146 (1.6); 6.136 (1.7); 6.128 (1.5); 6.037 (1.5); 6.029 (1.6); 6.019 (1.7); 6.011 (1.5); 5.447 (0.5); 4.072 (0.7); 4.064 (0.7); 4.056 (0.7); 4.048 (0.7); 4.035 (1.0); 4.027 (1.1); 4.020 (1.0); 4.012 (1.0); 4.002 (0.7); 3.994 (0.6); 3.987 (0.6); 3.978 (0.6); 3.966 (1.1); 3.957 (1.0); 3.950 (1.1); 3.942 (1.0); 3.922 (1.0); 3.906 (1.3); 3.904 (1.2); 3.888 (1.2); 3.870 (1.8); 3.852 (1.8); 3.836 (1.2); 3.816 (0.8); 3.799 (0.6); 2.591 (0.4); 2.138 (150.4); 2.120 (1.0); 2.114 (1.5); 2.108 (1.9); 2.101 (1.3); 2.095 (0.7); 1.964 (8.8); 1.958 (22.0); 1.952 (123.8); 1.946 (224.6); 1.940 (301.7); 1.934 (206.4); 1.928 (106.4); 1.915 (1.5); 1.781 (0.7); 1.775 (1.3); 1.769 (1.8); 1.762 (1.2); 1.756 (0.6); 1.269 (0.6); 0.008 (0.4); 0.000 (14.0); 0.009 (0.5) Example 1-84: 1H-NMR (400.0 MHz, CD3CN): = 8.844 (3.6); 8.837 (15.9); 8.835 (16.0); 8.828 (2.9); 8.661 (6.5); 8.647 (6.4); 7.898 (1.8); 7.856 (0.9); 7.838 (7.7); 7.816 (0.7); 7.811 (0.8); 7.799 (0.6); 7.789 (0.6); 7.771 (0.7); 7.767 (0.7); 7.757 (2.7); 7.737 (4.8); 7.733 (4.6); 7.691 (9.7); 7.671 (5.5); 7.629 (8.2); 7.614 (7.9); 7.599 (0.9); 7.584 (1.4); 7.580 (1.3); 7.562 (1.4); 7.552 (1.1); 7.529 (1.3); 7.521 (1.3); 7.511 (1.3); 7.502 (1.4); 7.481 (1.5); 7.461 (1.9); 7.450 (1.9); 7.436 (0.4); 7.417 (0.8); 7.398 (0.8); 7.392 (0.7); 7.380 (0.4); 7.373 (0.3); 6.293 (0.3); 6.288 (0.3); 6.226 (0.4); 6.160 (1.7); 6.152 (1.8); 6.142 (1.8); 6.134 (1.7); 6.043 (1.7); 6.035 (1.7); 6.025 (1.8); 6.017 (1.7); 4.086 (0.7); 4.077 (1.0); 4.068 (2.8); 4.061 (1.0); 4.050 (2.3); 4.040 (1.4); 4.032 (2.2); 4.025 (1.4); 4.016 (1.4); 4.007 (0.9); 3.999 (0.9); 3.992 (0.9); 3.984 (0.9); 3.971 (1.5); 3.963 (1.4); 3.955 (1.4); 3.947 (1.3); 3.927 (1.4); 3.911 (1.8); 3.893 (1.7); 3.874 (2.5); 3.856 (2.6); 3.840 (1.6); 3.821 (1.2); 3.804 (1.0); 3.051 (0.4); 2.138 (349.8); 2.120 (3.8); 2.114 (3.9); 2.108 (4.4); 2.101 (3.0); 2.095 (1.7); 1.972 (10.1); 1.964 (16.6); 1.958 (44.1); 1.952 (247.5); 1.946 (451.2); 1.940 (606.9); 1.934 (417.4); 1.928 (215.6); 1.869 (0.8); 1.844 (0.6); 1.809 (0.6); 1.781 (1.8); 1.775 (3.0); 1.769 (4.0); 1.762 (3.0); 1.756 (1.9); 1.733 (0.4); 1.707 (0.4); 1.655 (0.4); 1.619 (0.6); 1.597 (0.6); 1.564 (0.4); 1.469 (1.1); 1.386 (0.9); 1.372 (0.5); 1.348 (1.0); 1.340 (2.9); 1.285 (4.2); 1.270 (5.6); 1.222 (2.9); 1.204 (5.3); 1.186 (2.7); 0.882 (1.2); 0.857 (1.0); 0.841 (0.7); 0.008 (0.8); 0.000 (25.7); 0.008 (1.0) Example 1-83: 1H-NMR (400.0 MHz, CD3CN): = 8.801 (12.1); 8.796 (12.4); 8.759 (5.9); 8.747 (5.9); 8.605 (11.6); 8.599 (12.0); 8.103 (7.9); 8.097 (14.2); 8.092 (7.8); 7.868 (5.5); 7.848 (6.6); 7.819 (12.2); 7.749 (4.2); 7.744 (3.6); 7.728 (9.6); 7.724 (9.3); 7.710 (0.6); 7.698 (16.0); 7.678 (7.8); 7.662 (5.9); 7.655 (5.1); 7.643 (4.9); 7.584 (0.5); 7.395 (0.3); 7.277 (2.8); 6.135 (2.5); 6.127 (2.7); 6.118 (2.8); 6.110 (2.6); 6.018 (2.6); 6.010 (2.7); 6.001 (2.8); 5.993 (2.6); 4.086 (0.4); 4.068 (1.2); 4.050 (1.3); 4.041 (1.3); 4.033 (1.6); 4.026 (1.3); 4.018 (1.4); 4.005 (2.1); 3.997 (2.2); 3.989 (2.0); 3.981 (2.0); 3.973 (1.4); 3.965 (1.3); 3.957 (1.4); 3.949 (1.3); 3.936 (2.2); 3.928 (2.0); 3.921 (2.2); 3.913 (2.0); 3.886 (2.0); 3.870 (2.8); 3.853 (2.2); 3.832 (3.3); 3.816 (3.7); 3.798 (2.1); 3.795 (1.7); 3.778 (1.7); 3.761 (1.3); 2.140 (257.9); 2.120 (1.8); 2.114 (2.3); 2.108 (2.7); 2.101 (2.0); 2.095 (1.1); 1.972 (6.5); 1.964 (12.0); 1.958 (30.0); 1.952 (168.1); 1.946 (304.3); 1.940 (408.7); 1.934 (279.9); 1.928 (143.7); 1.781 (0.9); 1.775 (1.7); 1.769 (2.4); 1.762 (1.6); 1.756 (0.8); 1.437 (1.3); 1.340 (0.7); 1.285 (1.2); 1.269 (2.0); 1.222 (1.5); 1.204 (2.9); 1.186 (1.5); 0.881 (0.4); 0.858 (0.3); 0.008 (0.6); 0.000 (17.7); 0.009 (0.6) Example 1-82: 1H-NMR (400.0 MHz, CD3CN): = 8.846 (3.3); 8.838 (16.0); 8.831 (2.8); 8.787 (8.2); 8.782 (8.0); 8.602 (7.7); 8.596 (7.7); 8.088 (5.4); 8.083 (9.5); 8.077 (5.0); 7.913 (1.3); 7.900 (1.7); 7.809 (8.1); 7.717 (1.5); 7.713 (1.1); 7.696 (8.7); 7.692 (9.7); 7.688 (12.8); 7.668 (1.7); 6.159 (1.8); 6.151 (1.9); 6.141 (2.0); 6.133 (1.8); 6.042 (1.8); 6.034 (1.9); 6.024 (2.0); 6.016 (1.8); 5.447 (1.8); 4.076 (0.9); 4.068 (1.1); 4.061 (0.9); 4.053 (0.9); 4.040 (1.4); 4.032 (1.5); 4.024 (1.4); 4.016 (1.4); 4.007 (0.9); 3.998 (0.8); 3.991 (0.9); 3.983 (0.8); 3.970 (1.5); 3.962 (1.4); 3.954 (1.4); 3.946 (1.3); 3.926 (1.3); 3.908 (1.7); 3.891 (1.6); 3.873 (2.3); 3.855 (2.4); 3.839 (1.6); 3.820 (1.1); 3.803 (0.8); 2.136 (141.1); 2.120 (1.3); 2.114 (1.6); 2.107 (1.9); 2.101 (1.4); 2.095 (0.7); 1.972 (1.8); 1.964 (8.8); 1.958 (22.4); 1.952 (123.3); 1.946 (223.2); 1.940 (299.6); 1.934 (203.7); 1.928 (104.4); 1.781 (0.7); 1.775 (1.3); 1.769 (1.7); 1.762 (1.2); 1.756 (0.6); 1.340 (0.5); 1.285 (0.8); 1.270 (2.2); 1.222 (0.3); 1.204 (0.5); 0.881 (0.4); 0.008 (0.4); 0.000 (12.8); 0.008 (0.4) Example 1-81: 1H-NMR (400.0 MHz, CD3CN): = 8.759 (5.1); 8.757 (5.4); 8.747 (5.4); 8.745 (5.4); 8.296 (9.7); 8.282 (10.1); 7.872 (7.6); 7.869 (16.0); 7.865 (13.0); 7.848 (6.2); 7.845 (6.1); 7.804 (5.3); 7.799 (4.7); 7.784 (8.2); 7.779 (7.7); 7.714 (13.2); 7.694 (8.4); 7.672 (5.7); 7.660 (5.7); 7.653 (4.8); 7.641 (4.6); 7.593 (4.3); 7.588 (6.9); 7.584 (5.0); 7.580 (4.5); 7.575 (6.7); 7.571 (4.4); 7.340 (12.4); 7.268 (2.5); 6.138 (2.3); 6.130 (2.5); 6.121 (2.6); 6.113 (2.4); 6.021 (2.4); 6.013 (2.5); 6.004 (2.6); 5.996 (2.4); 5.447 (1.2); 4.068 (0.4); 4.050 (0.5); 4.044 (1.3); 4.036 (1.4); 4.029 (1.4); 4.021 (1.4); 4.008 (2.1); 4.000 (2.1); 3.992 (2.1); 3.984 (2.1); 3.976 (1.4); 3.968 (1.3); 3.961 (1.4); 3.953 (1.3); 3.940 (2.2); 3.932 (2.1); 3.924 (2.2); 3.916 (2.0); 3.890 (2.0); 3.874 (2.8); 3.857 (2.2); 3.853 (1.5); 3.834 (2.5); 3.818 (3.2); 3.800 (2.1); 3.797 (1.5); 3.781 (1.8); 3.764 (1.2); 2.141 (385.5); 2.120 (1.7); 2.114 (2.1); 2.108 (2.6); 2.101 (1.8); 2.095 (1.0); 1.972 (2.8); 1.964 (10.7); 1.958 (27.0); 1.953 (154.1); 1.946 (279.6); 1.940 (375.2); 1.934 (256.8); 1.928 (131.5); 1.915 (1.9); 1.781 (0.8); 1.775 (1.6); 1.769 (2.2); 1.763 (1.5); 1.756 (0.8); 1.285 (0.5); 1.269 (0.9); 1.222 (0.5); 1.204 (1.1); 1.186 (0.6); 0.008 (0.4); 0.000 (15.2); 0.009 (0.4) Example 1-98: 1H-NMR (400.0 MHz, CD3CN): = 8.741 (5.2); 8.707 (3.0); 8.696 (2.9); 8.509 (4.4); 8.502 (4.6); 7.930 (1.2); 7.909 (1.3); 7.855 (1.9); 7.849 (2.5); 7.844 (1.9); 7.830 (1.9); 7.824 (2.8); 7.812 (5.6); 7.776 (3.7); 7.755 (7.2); 7.717 (4.6); 7.712 (4.4); 7.696 (2.6); 7.691 (2.9); 7.668 (3.6); 7.650 (3.7); 7.602 (3.1); 7.591 (3.1); 7.583 (2.1); 7.571 (1.8); 7.553 (0.9); 7.535 (1.4); 7.515 (0.9); 7.451 (0.9); 7.432 (1.3); 7.413 (0.6); 7.061 (1.5); 4.338 (1.0); 4.322 (1.0); 4.302 (1.5); 4.285 (1.4); 4.267 (1.0); 4.250 (1.0); 4.230 (1.5); 4.214 (1.5); 4.146 (1.5); 4.131 (1.6); 4.110 (1.1); 4.093 (2.2); 4.078 (1.6); 4.068 (0.6); 4.056 (1.1); 4.050 (0.7); 4.041 (1.1); 2.769 (0.3); 2.143 (45.2); 2.114 (2.4); 2.108 (2.1); 2.101 (1.5); 1.972 (2.8); 1.964 (5.7); 1.958 (15.1); 1.952 (67.2); 1.946 (119.9); 1.940 (170.7); 1.934 (111.8); 1.928 (58.8); 1.879 (16.0); 1.781 (0.5); 1.775 (0.8); 1.769 (0.9); 1.762 (0.7); 1.756 (0.4); 1.285 (0.4); 1.269 (0.8); 1.222 (0.6); 1.204 (1.1); 1.186 (0.6); 0.000 (25.5) Example 1-99: 1H-NMR (400.0 MHz, CD3CN): = 8.740 (2.9); 8.736 (5.0); 8.732 (2.8); 8.506 (4.6); 8.499 (4.6); 7.851 (1.7); 7.846 (2.2); 7.845 (2.1); 7.840 (1.8); 7.833 (0.4); 7.826 (1.8); 7.821 (2.2); 7.820 (2.2); 7.815 (2.1); 7.810 (3.7); 7.806 (4.3); 7.781 (4.1); 7.760 (6.8); 7.703 (4.2); 7.698 (3.8); 7.683 (2.4); 7.678 (2.3); 7.504 (0.4); 7.400 (0.4); 7.394 (1.0); 7.381 (5.6); 7.376 (5.3); 7.366 (3.4); 7.361 (3.3); 7.346 (0.8); 7.341 (1.1); 7.324 (1.6); 7.318 (1.2); 7.308 (0.9); 7.305 (3.0); 7.300 (2.6); 7.289 (2.0); 7.284 (1.9); 7.272 (3.2); 7.270 (3.9); 7.267 (2.9); 7.253 (1.6); 7.249 (1.3); 6.963 (1.0); 5.448 (0.9); 4.349 (1.0); 4.332 (1.0); 4.313 (1.4); 4.296 (1.3); 4.278 (1.0); 4.261 (1.0); 4.241 (1.4); 4.224 (1.4); 4.129 (1.6); 4.115 (1.6); 4.093 (1.2); 4.078 (1.6); 4.076 (1.9); 4.061 (1.6); 4.039 (1.1); 4.025 (1.1); 2.468 (0.4); 2.463 (0.5); 2.458 (0.3); 2.152 (116.7); 2.120 (1.3); 2.114 (1.4); 2.108 (1.5); 2.102 (1.1); 2.095 (0.7); 1.965 (5.1); 1.958 (13.6); 1.953 (78.7); 1.946 (134.6); 1.940 (178.2); 1.934 (122.4); 1.928 (63.4); 1.890 (16.0); 1.858 (0.5); 1.781 (0.6); 1.775 (0.8); 1.769 (1.1); 1.763 (0.8); 1.757 (0.4); 1.437 (1.7); 1.270 (1.1); 0.008 (1.1); 0.000 (36.3); 0.009 (1.3) Example 1-100: 1H-NMR (400.0 MHz, CD3CN): = 8.731 (4.7); 8.503 (4.1); 8.496 (4.1); 7.848 (1.9); 7.843 (2.4); 7.842 (2.5); 7.837 (2.0); 7.823 (2.0); 7.818 (2.5); 7.816 (2.5); 7.812 (2.2); 7.802 (5.3); 7.783 (4.5); 7.763 (6.8); 7.711 (0.6); 7.702 (4.4); 7.697 (4.2); 7.681 (2.7); 7.677 (2.6); 7.568 (3.1); 7.566 (3.3); 7.548 (3.6); 7.546 (3.8); 7.445 (0.4); 7.442 (0.4); 7.426 (0.6); 7.423 (0.5); 7.420 (0.5); 7.407 (0.4); 7.401 (0.4); 7.365 (1.3); 7.362 (1.4); 7.346 (3.6); 7.343 (3.8); 7.328 (2.9); 7.325 (2.8); 7.298 (2.2); 7.293 (2.8); 7.278 (2.7); 7.274 (3.1); 7.259 (1.3); 7.255 (1.3); 7.220 (3.5); 7.216 (3.3); 7.201 (2.6); 7.197 (2.5); 6.924 (1.2); 4.356 (1.1); 4.339 (1.1); 4.320 (1.5); 4.303 (1.4); 4.284 (1.1); 4.267 (1.0); 4.248 (1.5); 4.231 (1.4); 4.114 (1.5); 4.099 (1.5); 4.077 (1.2); 4.067 (0.9); 4.061 (2.1); 4.049 (1.1); 4.046 (1.7); 4.024 (1.2); 4.010 (1.1); 2.251 (0.4); 2.153 (4.6); 2.114 (1.8); 2.108 (1.6); 2.102 (1.2); 2.054 (0.4); 1.972 (3.4); 1.965 (2.0); 1.953 (29.2); 1.947 (41.5); 1.940 (55.2); 1.934 (38.5); 1.928 (20.2); 1.916 (1.0); 1.895 (16.0); 1.858 (0.5); 1.775 (0.4); 1.769 (0.4); 1.436 (5.7); 1.285 (0.3); 1.268 (1.2); 1.221 (0.9); 1.204 (1.7); 1.186 (0.9); 0.000 (8.8); 0.009 (0.4) Example 1-101: 1H-NMR (400.0 MHz, CD3CN): = 8.742 (3.8); 8.509 (3.3); 8.502 (3.3); 7.855 (1.7); 7.850 (2.0); 7.848 (2.1); 7.843 (1.7); 7.829 (1.8); 7.825 (2.1); 7.823 (2.2); 7.818 (2.0); 7.814 (3.4); 7.810 (4.2); 7.807 (3.8); 7.785 (4.0); 7.764 (7.1); 7.717 (5.3); 7.712 (6.0); 7.696 (4.9); 7.691 (4.7); 7.621 (0.8); 7.604 (2.1); 7.602 (2.2); 7.587 (2.7); 7.582 (3.1); 7.563 (1.9); 7.561 (1.9); 7.544 (0.6); 7.291 (2.4); 7.274 (2.1); 7.003 (1.0); 5.448 (2.1); 4.296 (0.9); 4.279 (0.9); 4.259 (1.5); 4.243 (1.4); 4.226 (0.8); 4.210 (0.8); 4.190 (1.5); 4.173 (1.5); 4.156 (1.7); 4.141 (1.7); 4.119 (1.1); 4.104 (1.2); 4.101 (1.9); 4.086 (1.7); 4.065 (1.0); 4.049 (1.0); 2.469 (0.5); 2.464 (0.8); 2.459 (0.5); 2.164 (179.3); 2.120 (0.5); 2.114 (0.8); 2.108 (1.0); 2.102 (0.7); 2.096 (0.4); 1.965 (4.4); 1.959 (11.2); 1.953 (65.2); 1.947 (118.6); 1.941 (162.5); 1.934 (111.1); 1.928 (56.6); 1.916 (1.1); 1.878 (16.0); 1.781 (0.5); 1.775 (0.9); 1.769 (1.0); 1.763 (0.7); 1.757 (0.4); 1.285 (0.4); 1.269 (1.1); 0.008 (0.7); 0.000 (25.0); 0.009 (0.8) Example 1-102: 1H-NMR (400.0 MHz, CD3CN): = 8.798 (1.1); 8.792 (16.0); 8.785 (0.9); 8.730 (2.3); 8.725 (4.2); 8.721 (2.3); 8.505 (4.0); 8.498 (4.0); 7.840 (1.5); 7.835 (1.8); 7.834 (1.8); 7.829 (1.4); 7.815 (4.4); 7.811 (5.0); 7.804 (1.6); 7.758 (3.5); 7.737 (5.9); 7.683 (3.6); 7.678 (3.3); 7.662 (2.2); 7.657 (2.1); 7.619 (0.8); 5.448 (1.0); 4.306 (0.4); 4.290 (0.4); 4.269 (2.0); 4.254 (3.1); 4.247 (0.6); 4.239 (1.7); 4.231 (0.5); 4.218 (0.4); 4.211 (1.9); 4.202 (0.4); 4.194 (2.1); 4.191 (1.9); 4.175 (1.6); 4.154 (0.4); 4.138 (0.4); 4.068 (0.3); 4.050 (0.4); 3.078 (0.4); 2.815 (0.4); 2.469 (0.4); 2.465 (0.6); 2.460 (0.5); 2.166 (181.5); 2.121 (0.5); 2.114 (0.7); 2.108 (0.8); 2.102 (0.6); 2.096 (0.3); 1.972 (1.9); 1.965 (3.6); 1.959 (9.1); 1.953 (51.1); 1.947 (92.3); 1.941 (123.9); 1.935 (90.1); 1.928 (44.9); 1.916 (0.7); 1.872 (13.5); 1.775 (0.5); 1.769 (0.8); 1.763 (0.5); 1.437 (1.0); 1.270 (1.1); 1.222 (0.4); 1.204 (0.8); 1.186 (0.4); 0.008 (0.8); 0.000 (24.1); 0.009 (0.8) Example 1-103: 1H-NMR (400.0 MHz, CD3CN): = 8.745 (2.7); 8.741 (4.8); 8.736 (2.8); 8.508 (4.5); 8.501 (4.6); 7.855 (1.7); 7.850 (2.0); 7.848 (2.1); 7.843 (1.8); 7.830 (1.8); 7.825 (2.1); 7.823 (2.1); 7.818 (1.9); 7.809 (4.1); 7.763 (3.6); 7.742 (6.9); 7.702 (4.4); 7.697 (4.2); 7.681 (2.2); 7.676 (2.2); 7.587 (0.4); 7.459 (0.7); 7.443 (1.5); 7.438 (1.4); 7.426 (0.8); 7.421 (2.9); 7.417 (1.1); 7.405 (1.4); 7.400 (1.6); 7.384 (0.8); 7.167 (1.0); 7.017 (0.7); 7.014 (0.8); 7.007 (4.7); 6.996 (0.7); 6.993 (0.9); 6.987 (6.0); 6.978 (0.7); 6.967 (4.0); 6.959 (0.7); 6.957 (0.5); 5.448 (1.8); 4.264 (0.5); 4.248 (0.5); 4.228 (2.1); 4.212 (2.4); 4.209 (2.3); 4.193 (1.9); 4.169 (2.1); 4.153 (2.1); 4.143 (1.8); 4.128 (1.8); 4.107 (0.5); 4.092 (0.5); 3.169 (1.0); 2.471 (0.4); 2.466 (0.5); 2.461 (0.4); 2.160 (749.4); 2.121 (1.9); 2.114 (2.5); 2.108 (3.0); 2.102 (2.2); 2.096 (1.2); 1.965 (12.4); 1.959 (30.8); 1.953 (180.0); 1.947 (326.7); 1.941 (441.8); 1.934 (304.0); 1.928 (171.5); 1.868 (16.0); 1.781 (1.2); 1.775 (2.0); 1.769 (2.7); 1.763 (1.8); 1.757 (0.9); 1.270 (1.5); 0.008 (1.6); 0.000 (55.9); 0.009(1.8) Example 1-130: 1H-NMR (400.0 MHz, CDCl3): = 8.425 (4.3); 8.420 (4.4); 7.990 (1.6); 7.984 (1.6); 7.970 (2.6); 7.964 (2.5); 7.950 (1.7); 7.944 (1.7); 7.749 (5.2); 7.729 (6.2); 7.682 (2.5); 7.665 (3.1); 7.660 (3.1); 7.599 (5.9); 7.562 (0.9); 7.544 (3.1); 7.531 (6.2); 7.515 (2.9); 7.503 (4.1); 7.499 (4.3); 7.483 (3.3); 7.478 (3.1); 7.361 (2.9); 7.356 (3.1); 7.340 (2.6); 7.264 (98.3); 7.056 (2.9); 7.049 (2.9); 7.035 (2.7); 7.027 (2.7); 6.999 (0.6); 5.983 (2.0); 5.970 (1.2); 5.302 (9.7); 4.342 (4.7); 4.326 (4.5); 4.279 (4.9); 4.264 (4.7); 3.683 (0.5); 1.973 (15.9); 1.913 (16.0); 1.754 (0.3); 1.588 (127.4); 1.427 (0.7); 1.333 (1.0); 1.284 (1.6); 1.254 (6.9); 1.220 (0.6); 0.895 (0.5); 0.880 (1.0); 0.869 (0.7); 0.853 (0.9); 0.844 (0.8); 0.835 (0.8); 0.146 (0.4); 0.000 (89.5); 0.150 (0.5) Example 1-129: 1H-NMR (400.0 MHz, CDCl3): = 8.750 (3.4); 8.739 (3.4); 8.427 (4.5); 8.421 (4.7); 7.991 (1.7); 7.985 (1.7); 7.970 (2.8); 7.964 (2.6); 7.951 (1.8); 7.945 (1.7); 7.746 (7.4); 7.726 (9.5); 7.607 (6.0); 7.532 (3.1); 7.521 (4.1); 7.511 (5.7); 7.506 (4.3); 7.490 (3.3); 7.486 (3.2); 7.263 (194.9); 7.060 (2.9); 7.053 (3.0); 7.039 (2.8); 7.032 (2.8); 6.999 (1.1); 6.000 (2.0); 5.302 (7.6); 4.422 (0.7); 4.407 (0.8); 4.386 (1.7); 4.371 (1.7); 4.354 (0.7); 4.336 (2.1); 4.319 (3.0); 4.302 (2.0); 4.281 (2.2); 4.265 (1.9); 4.244 (0.7); 4.228 (0.7); 4.131 (0.4); 4.112 (0.4); 2.582 (0.3); 2.086 (0.8); 2.047 (1.9); 1.978 (15.9); 1.917 (16.0); 1.586 (239.3); 1.332 (0.4); 1.278 (1.0); 1.254 (3.2); 1.243 (1.0); 1.218 (0.4); 0.880 (0.5); 0.852 (0.5); 0.840 (0.5); 0.146 (0.9); 0.000 (178.7); 0.150 (0.9) Example 1-89: 1H-NMR (400.0 MHz, d6-DMSO): = 9.385 (11.9); 9.204 (2.5); 9.188 (5.5); 9.172 (2.6); 8.795 (5.1); 8.792 (5.6); 8.783 (5.4); 8.781 (5.5); 8.313 (16.0); 8.218 (8.7); 8.212 (9.5); 8.064 (4.5); 8.058 (4.3); 8.042 (5.6); 8.036 (5.4); 7.873 (4.1); 7.871 (4.5); 7.854 (6.5); 7.851 (6.5); 7.836 (10.1); 7.815 (8.5); 7.782 (5.8); 7.771 (5.6); 7.763 (4.0); 7.751 (3.9); 4.283 (2.2); 4.267 (2.3); 4.247 (5.1); 4.231 (4.9); 4.211 (2.6); 4.195 (2.4); 3.330 (217.0); 2.712 (1.3); 2.681 (0.4); 2.677 (0.7); 2.672 (1.0); 2.668 (0.8); 2.663 (0.4); 2.542 (342.1); 2.526 (2.3); 2.521 (3.2); 2.512 (55.7); 2.508 (117.7); 2.503 (158.5); 2.498 (114.8); 2.494 (55.0); 2.368 (1.3); 2.339 (0.3); 2.334 (0.7); 2.330 (1.0); 2.325 (0.7); 0.008 (0.9); 0.000 (31.5); 0.009 (1.0) Example 1-90: 1H-NMR (400.0 MHz, d6-DMSO): = 9.041 (0.5); 9.026 (1.2); 9.010 (0.6); 8.606 (2.0); 8.600 (2.0); 8.145 (1.3); 8.139 (1.3); 8.124 (1.3); 8.117 (1.3); 7.939 (2.2); 7.823 (0.9); 7.819 (0.8); 7.803 (1.3); 7.799 (1.3); 7.777 (1.2); 7.758 (1.7); 7.729 (2.5); 7.716 (1.5); 7.708 (1.9); 7.697 (1.1); 7.664 (1.0); 7.645 (1.2); 7.626 (0.4); 7.393 (1.3); 7.374 (1.3); 6.963 (2.1); 6.942 (2.0); 4.260 (0.5); 4.244 (0.5); 4.224 (1.1); 4.208 (1.1); 4.188 (0.6); 4.172 (0.6); 3.917 (16.0); 3.904 (0.4); 3.885 (0.6); 3.351 (397.5); 2.683 (0.4); 2.679 (0.5); 2.674 (0.4); 2.549 (57.3); 2.532 (1.2); 2.518 (32.2); 2.514 (66.3); 2.510 (88.4); 2.505 (64.7); 2.501 (32.0); 2.341 (0.4); 2.336 (0.6); 2.332 (0.4) Example 1-91: 1H-NMR (400.0 MHz, d6-DMSO): = 9.041 (0.5); 9.026 (1.1); 9.010 (0.5); 8.579 (1.9); 8.574 (2.0); 8.110 (1.3); 8.103 (1.3); 8.088 (1.4); 8.081 (1.3); 7.929 (1.9); 7.926 (2.1); 7.813 (0.8); 7.809 (0.8); 7.792 (1.3); 7.788 (1.3); 7.777 (1.1); 7.757 (1.4); 7.733 (0.5); 7.721 (2.4); 7.700 (1.8); 7.663 (0.9); 7.644 (1.1); 7.625 (0.4); 7.391 (1.2); 7.372 (1.1); 6.873 (2.0); 6.852 (2.0); 5.343 (0.4); 5.327 (1.1); 5.312 (1.5); 5.296 (1.1); 5.281 (0.4); 4.258 (0.5); 4.242 (0.5); 4.221 (1.0); 4.206 (1.0); 4.185 (0.5); 4.170 (0.5); 3.350 (277.8); 3.301 (0.3); 2.679 (0.4); 2.549 (44.0); 2.532 (0.9); 2.527 (1.3); 2.519 (23.8); 2.514 (50.4); 2.510 (67.8); 2.505 (49.3); 2.501 (23.8); 2.336 (0.4); 1.333 (16.0); 1.317 (15.9) Example 1-96: 1H-NMR (400.0 MHz, d6-DMSO): = 9.053 (2.9); 9.037 (6.3); 9.021 (3.0); 8.901 (7.4); 8.897 (13.8); 8.893 (7.5); 8.659 (13.5); 8.652 (13.9); 8.241 (4.2); 8.236 (5.1); 8.234 (5.3); 8.229 (4.1); 8.215 (4.3); 8.210 (5.4); 8.209 (5.1); 8.204 (4.0); 8.099 (10.8); 8.095 (11.8); 7.955 (5.3); 7.951 (5.3); 7.934 (6.6); 7.930 (6.6); 7.776 (14.7); 7.755 (16.0); 7.730 (2.7); 7.712 (6.8); 7.694 (4.9); 7.659 (5.0); 7.640 (6.1); 7.621 (2.2); 7.390 (7.1); 7.371 (6.4); 4.270 (2.6); 4.254 (2.7); 4.234 (6.1); 4.218 (5.9); 4.198 (3.1); 4.182 (2.9); 3.341 (545.8); 3.307 (0.9); 3.288 (0.4); 3.282 (0.4); 2.712 (1.9); 2.681 (0.3); 2.677 (0.7); 2.672 (1.0); 2.668 (0.7); 2.663 (0.4); 2.572 (0.4); 2.543 (467.7); 2.526 (2.6); 2.521 (3.2); 2.512 (54.3); 2.508 (115.3); 2.503 (155.6); 2.499 (112.8); 2.494 (54.5); 2.369 (2.0); 2.339 (0.4); 2.335 (0.8); 2.330 (1.0); 2.325 (0.8); 1.785 (0.6); 1.755 (0.5); 1.752 (0.5); 1.739 (0.4); 1.298 (0.3); 1.268 (0.4); 1.259 (0.5); 1.234 (0.8); 1.214 (0.5); 0.000 (0.6) Example 1-97: 1H-NMR (400.0 MHz, d6-DMSO): = 9.051 (1.0); 9.035 (2.2); 9.019 (1.1); 8.964 (4.9); 8.959 (5.1); 8.699 (4.7); 8.693 (4.9); 8.403 (3.0); 8.398 (5.3); 8.392 (3.0); 8.110 (3.9); 8.107 (4.3); 7.954 (1.9); 7.950 (1.9); 7.934 (2.4); 7.930 (2.4); 7.770 (6.2); 7.750 (5.8); 7.729 (1.0); 7.711 (2.5); 7.693 (1.8); 7.658 (1.8); 7.639 (2.2); 7.620 (0.8); 7.390 (2.6); 7.371 (2.3); 4.268 (1.0); 4.252 (1.0); 4.232 (2.2); 4.216 (2.1); 4.195 (1.1); 4.179 (1.0); 3.326 (32.6); 2.676 (0.4); 2.671 (0.5); 2.667 (0.4); 2.525 (1.2); 2.511 (28.6); 2.507 (59.2); 2.502 (79.1); 2.498 (58.2); 2.493 (28.7); 2.333 (0.4); 2.329 (0.5); 2.325 (0.4); 1.989 (1.4); 1.398 (16.0); 1.193 (0.4); 1.175 (0.7); 1.157 (0.4); 0.000 (5.0) Example 1-92: 1H-NMR (400.0 MHz, d6-DMSO): = 9.052 (0.7); 9.036 (1.5); 9.020 (0.8); 8.220 (2.8); 8.075 (16.0); 8.050 (1.4); 8.034 (1.5); 8.030 (1.6); 7.907 (0.3); 7.787 (2.7); 7.766 (3.0); 7.751 (2.3); 7.725 (0.9); 7.708 (1.9); 7.690 (1.4); 7.658 (1.4); 7.639 (1.7); 7.620 (0.6); 7.585 (0.5); 7.565 (0.4); 7.381 (1.7); 7.363 (1.8); 4.265 (0.6); 4.250 (0.6); 4.230 (1.5); 4.214 (1.5); 4.194 (0.8); 4.178 (0.8); 3.334 (1643.1); 2.711 (0.7); 2.676 (2.7); 2.671 (3.8); 2.667 (2.8); 2.541 (180.1); 2.524 (8.6); 2.520 (13.1); 2.511 (209.8); 2.507 (435.9); 2.502 (582.2); 2.497 (418.5); 2.493 (199.4); 2.368 (0.7); 2.333 (2.6); 2.329 (3.7); 2.324 (2.6); 1.298 (0.5); 1.258 (0.7); 1.235 (1.1); 0.000 (3.5) Example 1-95: 1H-NMR (400.0 MHz, d6-DMSO): = 10.656 (2.1); 9.035 (0.7); 9.019 (1.5); 9.003 (0.7); 8.420 (2.6); 8.407 (3.1); 8.398 (2.1); 7.912 (3.2); 7.811 (7.2); 7.766 (1.4); 7.747 (1.9); 7.725 (0.6); 7.708 (1.6); 7.690 (1.2); 7.654 (1.2); 7.635 (1.4); 7.617 (0.5); 7.486 (1.9); 7.482 (1.8); 7.473 (1.8); 7.468 (1.9); 7.384 (1.7); 7.365 (1.5); 4.266 (0.6); 4.251 (0.6); 4.230 (1.3); 4.215 (1.3); 4.195 (0.7); 4.179 (0.6); 3.337 (126.0); 2.712 (0.6); 2.542 (149.0); 2.526 (0.7); 2.521 (1.1); 2.512 (16.8); 2.507 (35.8); 2.503 (48.4); 2.498 (35.2); 2.494 (17.0); 2.368 (0.6); 2.127 (16.0); 0.000 (0.4) Example 1-93: 1H-NMR (400.0 MHz, d6-DMSO): = 9.046 (4.0); 9.030 (8.2); 9.015 (4.0); 8.984 (0.9); 8.969 (0.5); 8.669 (12.2); 8.663 (11.8); 8.429 (3.9); 8.422 (3.8); 8.409 (6.8); 8.402 (6.5); 8.388 (4.1); 8.382 (3.7); 8.317 (0.4); 8.026 (15.0); 8.024 (15.0); 7.912 (1.6); 7.881 (6.6); 7.861 (9.2); 7.858 (8.6); 7.818 (0.5); 7.796 (0.6); 7.771 (10.0); 7.763 (16.0); 7.752 (13.0); 7.743 (11.5); 7.728 (4.6); 7.710 (10.4); 7.692 (7.3); 7.658 (7.4); 7.639 (8.9); 7.620 (3.2); 7.587 (1.6); 7.565 (1.2); 7.389 (9.4); 7.370 (9.1); 7.353 (7.8); 7.346 (8.0); 7.331 (7.3); 7.324 (7.1); 4.264 (3.6); 4.248 (3.8); 4.228 (8.1); 4.212 (8.2); 4.192 (4.5); 4.176 (4.7); 4.160 (1.2); 4.141 (0.6); 4.124 (0.5); 3.520 (0.4); 3.504 (0.3); 3.492 (0.3); 3.471 (0.5); 3.458 (0.5); 3.335 (1503.3); 3.277 (1.1); 3.247 (0.4); 2.996 (0.4); 2.712 (3.5); 2.672 (3.3); 2.667 (2.5); 2.608 (0.6); 2.593 (1.0); 2.542 (741.1); 2.525 (17.8); 2.507 (414.3); 2.503 (507.8); 2.499 (372.9); 2.404 (0.4); 2.368 (3.6); 2.329 (3.2); 1.299 (0.4); 1.258 (0.6); 1.235 (1.2); 0.000 (2.3) Example 1-94: 1H-NMR (400.0 MHz, d6-DMSO): = 9.211 (0.4); 9.183 (12.5); 9.178 (12.6); 9.057 (4.0); 9.042 (8.6); 9.026 (4.1); 9.000 (0.3); 8.983 (0.6); 8.886 (0.6); 8.873 (0.7); 8.495 (6.3); 8.490 (6.2); 8.474 (6.9); 8.469 (7.0); 8.316 (0.9); 8.240 (0.8); 8.162 (0.5); 8.134 (14.2); 8.131 (15.2); 8.072 (0.4); 8.068 (0.5); 8.050 (14.1); 8.030 (12.6); 7.978 (6.7); 7.974 (6.6); 7.957 (8.6); 7.953 (8.6); 7.912 (1.0); 7.908 (1.1); 7.894 (0.3); 7.815 (16.0); 7.794 (12.8); 7.771 (8.5); 7.752 (11.6); 7.728 (3.9); 7.710 (9.4); 7.692 (6.8); 7.659 (7.2); 7.640 (8.8); 7.621 (3.1); 7.586 (1.2); 7.565 (1.0); 7.394 (9.6); 7.376 (8.6); 7.347 (0.7); 4.278 (3.5); 4.263 (3.7); 4.242 (8.0); 4.227 (7.8); 4.206 (4.2); 4.191 (3.9); 4.176 (0.9); 4.159 (0.7); 4.140 (0.4); 4.124 (0.4); 3.483 (0.3); 3.455 (0.5); 3.441 (0.5); 3.428 (0.6); 3.338 (1455.9); 3.299 (1.0); 3.282 (0.4); 3.274 (0.4); 2.996 (0.5); 2.712 (3.7); 2.681 (1.0); 2.676 (2.0); 2.672 (2.9); 2.667 (2.2); 2.663 (1.2); 2.617 (0.4); 2.589 (0.6); 2.573 (1.1); 2.542 (905.4); 2.525 (6.7); 2.520 (9.1); 2.512 (158.0); 2.507 (333.2); 2.503 (449.2); 2.498 (326.9); 2.494 (158.7); 2.445 (0.4); 2.368 (3.7); 2.338 (0.9); 2.334 (2.0); 2.329 (2.8); 2.325 (2.1); 1.298 (0.4); 1.258 (0.6); 1.234 (1.0); 0.000 (2.1) Example 1-104: 1H-NMR (400.0 MHz, d6-DMSO): = 9.215 (3.0); 9.200 (6.5); 9.184 (3.1); 8.798 (6.5); 8.789 (6.3); 8.786 (6.5); 8.673 (8.8); 8.667 (9.3); 8.432 (3.2); 8.425 (3.2); 8.411 (5.1); 8.405 (5.0); 8.391 (3.4); 8.384 (3.3); 8.035 (10.9); 8.032 (11.7); 7.884 (5.1); 7.880 (5.5); 7.875 (5.7); 7.872 (5.8); 7.864 (7.6); 7.859 (8.8); 7.856 (9.3); 7.790 (6.7); 7.778 (6.9); 7.769 (16.0); 7.758 (5.0); 7.748 (8.9); 7.356 (5.7); 7.349 (5.8); 7.334 (5.6); 7.327 (5.6); 4.293 (2.7); 4.277 (2.8); 4.256 (6.1); 4.240 (5.9); 4.220 (3.1); 4.204 (2.9); 3.334 (39.3); 2.678 (0.4); 2.673 (0.5); 2.669 (0.4); 2.527 (1.8); 2.513 (30.2); 2.509 (60.8); 2.505 (80.1); 2.500 (59.1); 2.496 (29.3); 2.336 (0.3); 2.331 (0.5); 2.327 (0.3); 1.991 (1.1); 1.260 (0.4); 1.232 (0.7); 1.194 (0.4); 1.176 (0.6); 1.158 (0.3); 0.146 (0.6); 0.008 (4.8); 0.000 (122.4); 0.009 (4.8); 0.150 (0.5) Example 1-136: 1H-NMR (400.0 MHz, d6-DMSO): = 9.087 (1.7); 9.072 (3.5); 9.056 (1.7); 8.610 (4.9); 8.605 (5.2); 8.366 (1.7); 8.359 (1.7); 8.345 (3.0); 8.339 (3.0); 8.325 (1.8); 8.318 (1.9); 7.787 (3.4); 7.767 (4.6); 7.740 (1.6); 7.720 (8.4); 7.704 (3.4); 7.671 (5.3); 7.649 (3.6); 7.630 (1.4); 7.610 (6.3); 7.589 (4.1); 7.389 (4.0); 7.370 (3.6); 7.330 (3.1); 7.323 (3.2); 7.309 (3.1); 7.302 (3.1); 4.109 (1.5); 4.093 (1.6); 4.071 (3.4); 4.056 (3.4); 4.033 (1.8); 4.018 (1.7); 3.334 (154.4); 2.676 (0.5); 2.672 (0.7); 2.668 (0.5); 2.569 (16.0); 2.507 (82.7); 2.503 (107.7); 2.499 (82.1); 2.334 (0.6); 2.330 (0.7); 2.325 (0.6); 1.989 (0.7); 1.397 (7.2); 1.175 (0.4); 0.008 (0.6); 0.000 (12.6) Example 1-141: 1H-NMR (400.0 MHz, d6-DMSO): = 8.897 (0.9); 8.881 (1.8); 8.866 (0.9); 8.654 (2.7); 8.649 (2.8); 8.406 (0.8); 8.400 (0.8); 8.386 (1.5); 8.379 (1.5); 8.366 (0.9); 8.359 (0.8); 7.757 (1.8); 7.737 (2.4); 7.706 (0.8); 7.688 (2.0); 7.669 (1.5); 7.639 (1.5); 7.620 (1.8); 7.601 (0.7); 7.581 (2.3); 7.561 (2.9); 7.473 (3.6); 7.412 (2.1); 7.392 (1.7); 7.340 (1.6); 7.334 (1.7); 7.318 (3.5); 7.299 (1.9); 4.205 (0.8); 4.190 (0.9); 4.169 (1.8); 4.153 (1.7); 4.132 (0.9); 4.117 (0.9); 3.979 (16.0); 3.335 (76.2); 2.672 (0.4); 2.507 (45.7); 2.503 (56.3); 2.329 (0.4); 1.990 (0.4); 0.000 (7.0) Example 1-135: 1H-NMR (400.0 MHz, d6-DMSO): = 9.167 (3.5); 9.152 (7.4); 9.136 (3.5); 8.726 (10.8); 8.720 (11.3); 8.471 (3.7); 8.465 (3.7); 8.450 (5.9); 8.445 (5.6); 8.431 (3.9); 8.424 (3.8); 8.317 (0.8); 7.774 (16.0); 7.760 (11.4); 7.746 (15.1); 7.735 (10.6); 7.716 (5.9); 7.671 (6.0); 7.652 (7.5); 7.633 (2.8); 7.581 (0.4); 7.416 (8.8); 7.398 (7.9); 7.369 (6.7); 7.362 (6.9); 7.347 (6.7); 7.340 (6.6); 4.162 (3.1); 4.146 (3.3); 4.127 (7.1); 4.111 (6.9); 4.092 (3.7); 4.076 (3.4); 4.038 (0.4); 4.020 (0.4); 3.331 (351.1); 2.676 (1.5); 2.672 (2.1); 2.667 (1.6); 2.525 (5.6); 2.512 (119.4); 2.507 (241.2); 2.503 (318.2); 2.498 (236.1); 2.494 (119.3); 2.334 (1.5); 2.330 (2.1); 2.325 (1.5); 1.989 (1.5); 1.398 (9.2); 1.193 (0.4); 1.175 (0.8); 1.157 (0.4); 0.008 (1.0); 0.000 (28.8); 0.008 (1.3)

TABLE-US-00004 TABLE 4 LC-MS and NMR spectra of selected compounds Example no. LC-MS NMR (Method M2) 1-105 (Method L2): R.sub.t = 3.92 1H NMR (300 MHz, DMSO-d6) 9.20-9.15 min; m/z = 493 (M + H).sup.+ (m, 1H), 9.05 (t, J = 6.2 Hz, 1H), 8.50-8.43 (m, 1H), 8.04 (d, J = 8.3 Hz, 1H), 7.95 (d, J = 12.5 Hz, 1H), 7.87-7.59 (m, 5H), 7.39 (d, J = 7.0 Hz, 1H), 4.20-4.07 (m, 2H). 1-106 (Method L2): R.sub.t = 3.27 1H NMR (300 MHz, DMSO-d6) 9.04 (t, J = min; m/z = 443 (M + H).sup.+ 6.3 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.45-8.31 (m, 1H), 7.90-7.54 (m, 6H), 7.42-7.29 (m, 2H), 4.20-4.02 (m, 2H). 1-107 (Method L1): R.sub.t = 3.41 1H NMR (300 MHz, DMSO-d6) 9.09-8.99 min; m/z = 459 (M + H).sup.+ (m, 1H), 8.96 (s, 1H), 8.69 (s, 1H), 8.38 (s, 1H), 7.92 (d, J = 12.4 Hz, 1H), 7.72 (ddt, J = 32.8, 14.9, 7.7 Hz, 5H), 7.38 (d, J = 6.9 Hz, 1H), 4.22-4.00 (m, 2H). 1-108 (Method L1): R.sub.t = 3.07 1H NMR (300 MHz, DMSO-d6) 9.04 (t, J = min; m/z = 455 (M + H).sup.+ 5.4 Hz, 1H), 8.57 (s, 1H), 8.35 (s, 1H), 7.87 (d, J = 12.6 Hz, 1H), 7.81-7.57 (m, 6H), 7.38 (d, J = 7.4 Hz, 1H), 4.22-4.02 (m, 2H), 3.92 (s, 3H). 1-109 (Method L1): R.sub.t = 2.47 1H NMR (300 MHz, DMSO-d6) 9.01 (t, J = min; m/z = 468 (M + H).sup.+ 6.2 Hz, 1H), 8.54 (d, J = 2.6 Hz, 1H), 7.93 (d, J = 8.9, 2.7 Hz, 1H), 7.80-7.52 (m, 6H), 7.38 (d, J = 7.2 Hz, 1H), 6.73 (d, J = 9.1 Hz, 1H), 4.18-3.99 (m, 2H), 3.08 (s, 6H). 1-110 (Method L1): R.sub.t = 3.44 1H NMR (300 MHz, DMSO-d6) 9.03 (t, J = min; m/z = 455 (M + H).sup.+ 5.9 Hz, 1H), 8.60 (s, 1H), 8.12 (d, J = 8.7, 2.6 Hz, 1H), 7.83-7.56 (m, 6H), 7.38 (d, J = 7.8 Hz, 1H), 6.94 (d, J = 8.7 Hz, 1H), 4.20-4.02 (m, 2H), 3.91 (s, 3H). 1-111 (Method L1): R.sub.t = 4.51 1H NMR (300 MHz, DMSO-d6) 9.04 (t, J = min; m/z = 443 (M + H).sup.+ 6.2 Hz, 1H), 8.90 (d, J = 1.7 Hz, 1H), 8.65 (d, J = 2.7 Hz, 1H), 8.20 (d, J = 10.3, 2.3 Hz, 1H), 7.92 (d, J = 12.7 Hz, 1H), 7.86-7.57 (m, 5H), 7.38 (d, J = 7.4 Hz, 1H), 4.23-4.02 (m, 2H). 1-112 (Method L1): R.sub.t = 2.99 1H NMR (300 MHz, DMSO-d6) 9.32 (s, 1H), min; m/z = 503 (M + H).sup.+ 9.13-9.00 (m, 2H), 8.64 (t, J = 2.2 Hz, 1H), 8.02 (d, J = 12.4 Hz, 1H), 7.93-7.59 (m, 5H), 7.39 (d, J = 7.1 Hz, 1H), 4.28-4.03 (m, 2H), 3.42 (s, 3H). 1-113 (Method L1): R.sub.t = 2.98 1H NMR (300 MHz, DMSO-d6) 10.67 (s, min; m/z = 482 (M + H).sup.+ 1H), 9.03 (t, J = 6.2 Hz, 1H), 8.74 (s, 1H), 8.18 (s, 2H), 7.85-7.57 (m, 6H), 7.38 (d, J = 7.0 Hz, 1H), 4.20-4.01 (m, 2H), 2.12 (s, 3H). 1-114 (Method L1): R.sub.t = 3.38 1H NMR (300 MHz, DMSO-d6) 9.04 (t, J = min; m/z = 459 (M + H).sup.+ 6.1 Hz, 1H), 8.84 (d, J = 2.6 Hz, 1H), 8.27 (dd, J = 8.4, 2.6 Hz, 1H), 7.87 (d, J = 12.5 Hz, 1H), 7.79-7.60 (m, 6H), 7.38 (d, J = 7.0 Hz, 1H), 4.20-4.04 (m, 2H). 1-115 (Method L1): R.sub.t = 3.23 1H NMR (300 MHz, DMSO-d6) 9.00 (t, J = min; m/z = 496 (M + H).sup.+ 6.2 Hz, 1H), 8.45 (s, 1H), 8.18 (s, 1H), 7.80-7.50 (m, 6H), 7.37 (d, J = 7.3 Hz, 1H), 5.17 (q, J = 9.1 Hz, 2H), 4.17-3.99 (m, 2H). 1-116 (Method L1): R.sub.t = 3.01 1H NMR (300 MHz, DMSO-d6) 9.00 (t, J = min; m/z = 428 (M + H).sup.+ 6.0 Hz, 1H), 8.29 (s, 1H), 7.99 (s, 1H), 7.79-7.47 (m, 6H), 7.36 (d, J = 7.3 Hz, 1H), 4.16-3.96 (m, 2H), 3.87 (s, 3H). 1-117 (Method L1): R.sub.t = 2.87 1H NMR (300 MHz, DMSO-d6) 13.09 (s, min; m/z = 414 (M + H).sup.+ 1H), 9.00 (t, J = 6.2 Hz, 1H), 8.36 (s, 1H), 8.06 (s, 1H), 7.83-7.49 (m, 6H), 7.37 (d, J = 7.7 Hz, 1H), 4.19-3.96 (m, 2H). 1-118 (Method L1): R.sub.t = 3.13 1H NMR (300 MHz, DMSO-d6) 9.28 (s, 1H), min; m/z = 450 (M + H).sup.+ 9.10-9.01 (m, 2H), 8.77 (s, 1H), 7.96 (d, J = 12.5 Hz, 1H), 7.85 (d, J = 8.2 Hz, 1H), 7.78-7.60 (m, 4H), 7.38 (d, J = 7.4 Hz, 1H), 4.20-4.05 (m, 2H). 1-119 (Method L1): R.sub.t = 3.49 1H NMR (300 MHz, DMSO-d6) 9.35 (d, J = min; m/z = 551 (M H).sup. 2.2 Hz, 1H), 9.18-9.06 (m, 2H), 8.70 (t, J = 2.1 Hz, 1H), 8.35 (d, J = 10.5 Hz, 2H), 7.95 (d, J = 8.2 Hz, 1H), 7.81-7.62 (m, 3H), 7.46 (d, J = 7.0 Hz, 1H), 4.21-4.04 (m, 2H), 3.42 (s, 3H). 1-120 (Method L1): R.sub.t = 3.50 1H NMR (300 MHz, DMSO-d6) 9.09 (t, J = min; m/z = 509 (M + H).sup.+ 6.2 Hz, 1H), 8.97 (d, J = 1.9 Hz, 1H), 8.70 (d, J = 2.2 Hz, 1H), 8.47-8.41 (m, 1H), 8.26 (d, J = 7.4 Hz, 2H), 7.88 (d, J = 8.7 Hz, 1H), 7.79-7.59 (m, 3H), 7.43 (d, J = 7.0 Hz, 1H), 4.20-3.96 (m, 2H). 1-121 (Method L1): R.sub.t = 3.22 1H NMR (300 MHz, DMSO-d6) 9.11 (t, J = min; m/z = 505 (M + H).sup.+ 6.2 Hz, 1H), 8.59 (d, J = 1.8 Hz, 1H), 8.38 (d, J = 2.7 Hz, 1H), 8.24 (d, J = 6.7 Hz, 2H), 7.89 (d, J = 8.9 Hz, 1H), 7.81-7.61 (m, 4H), 7.45 (d, J = 7.4 Hz, 1H), 4.11 (td, J = 14.6, 6.3 Hz, 2H), 3.94 (s, 3H). 1-122 (Method L1): R.sub.t = 3.37 1H NMR (300 MHz, DMSO-d6) 9.11 (t, J = min; m/z = 493 (M + H)+ 6.1 Hz, 1H), 8.71 (d, J = 2.5 Hz, 1H), 8.51-8.41 (m, 1H), 8.21 (d, J = 4.8 Hz, 2H), 7.89 (d, J = 8.8 Hz, 1H), 7.81-7.61 (m, 3H), 7.45 (d, J = 7.0 Hz, 1H), 7.36 (d, J = 8.6, 2.9 Hz, 1H), 4.19-4.02 (m, 2H). 1-123 (Method L1): R.sub.t = 3.18 1H NMR (300 MHz, DMSO-d6) 10.70 (s, min; m/z = 532 (M + H)+ 1H), 9.10 (t, J = 6.2 Hz, 1H), 8.78 (d, J = 1.5 Hz, 1H), 8.29-8.13 (m, 4H), 7.86 (d, J = 9.0 Hz, 1H), 7.81-7.60 (m, 3H), 7.45 (d, J = 7.2 Hz, 1H), 4.19-3.99 (m, 2H), 2.13 (s, 3H). 1-124 (Method L1): R.sub.t = 3.61 1H NMR (300 MHz, DMSO-d6) 9.22 (s, 1H), min; m/z = 543 (M + H).sup.+ 9.12 (t, J = 6.2 Hz, 1H), 8.53 (d, J = 8.2, 2.1 Hz, 1H), 8.31 (d, J = 6.7 Hz, 2H), 8.06 (d, J = 8.2 Hz, 1H), 7.94 (d, J = 8.9 Hz, 1H), 7.81-7.61 (m, 3H), 7.46 (d, J = 7.4 Hz, 1H), 4.22-4.01 (m, 2H). 1-125 (Method L1): R.sub.t = 2.68 1H NMR (300 MHz, DMSO-d6) 9.08 (t, J = min; m/z = 518 (M + H).sup.+ 6.1 Hz, 1H), 8.57 (d, J = 2.6 Hz, 1H), 8.07 (d, J = 10.9 Hz, 2H), 7.98 (dd, J = 8.8, 2.3 Hz, 1H), 7.82-7.61 (m, 4H), 7.44 (d, J = 7.7 Hz, 1H), 6.76 (d, J = 9.0 Hz, 1H), 4.15-3.99 (m, 2H), 3.09 (s, 6H). 1-126 (Method L1): R.sub.t = 3.55 1H NMR (300 MHz, DMSO-d6) 9.08 (t, J = min; m/z = 509 (M + H).sup.+ 6.3 Hz, 1H), 8.86 (d, J = 2.2 Hz, 1H), 8.30 (dd, J = 8.4, 2.7 Hz, 1H), 8.21 (d, J = 5.0 Hz, 2H), 7.88 (d, J = 8.8 Hz, 1H), 7.78-7.59 (m, 4H), 7.43 (d, J = 7.6 Hz, 1H), 4.17-3.98 (m, 2H). 1-127 (Method L1): R.sub.t = 3.55 1H NMR (300 MHz, DMSO-d6) 9.10 (t, J = min; m/z = 505 (M + H).sup.+ 6.1 Hz, 1H), 8.64 (d, J = 2.2 Hz, 1H), 8.21-8.11 (m, 3H), 7.85 (d, J = 8.1 Hz, 1H), 7.81-7.61 (m, 3H), 7.45 (d, J = 7.4 Hz, 1H), 6.97 (d, J = 8.6 Hz, 1H), 4.17-4.01 (m, 2H), 3.92 (s, 3H). 1-128 (Method L1): R.sub.t = 3.44 1H NMR (300 MHz, DMSO-d6) 9.11 (t, J = min; m/z = 493 (M + H).sup.+ 6.1 Hz, 1H), 8.71 (d, J = 2.5 Hz, 1H), 8.51-8.41 (m, 1H), 8.21 (d, J = 4.8 Hz, 2H), 7.89 (d, J = 8.8 Hz, 1H), 7.81-7.61 (m, 3H), 7.45 (d, J = 7.0 Hz, 1H), 7.36 (d, J = 8.6, 2.9 Hz, 1H), 4.19-4.02 (m, 2H). 1-131 (Method L1): R.sub.t = 3.30 1H NMR (300 MHz, DMSO-d6) 9.06 (t, J = min; m/z = 544 (M H).sup. 6.2 Hz, 1H), 8.58 (s, 1H), 8.27 (s, 1H), 8.13-8.03 (m, 2H), 7.85-7.60 (m, 4H), 7.44 (d, J = 7.4 Hz, 1H), 5.28-5.10 (m, 2H), 4.18-3.96 (m, 2H). 1-132 (Method L1): R.sub.t = 3.09 1H NMR (300 MHz, DMSO-d6) 9.06 (t, J = min; m/z = 478 (M + H).sup.+ 6.3 Hz, 1H), 8.41 (s, 1H), 8.07 (d, J = 0.7 Hz, 1H), 8.05-7.96 (m, 2H), 7.80-7.61 (m, 4H), 7.43 (d, J = 7.3 Hz, 1H), 4.15-3.96 (m, 2H), 3.88 (s, 3H). 1-133 (Method L1): R.sub.t = 3.45 1H NMR (300 MHz, DMSO-d6) 13.17 (s, min; m/z = 462 (M H).sup. 1H), 9.06 (t, J = 6.3 Hz, 1H), 8.62-8.01 (m, 4H), 7.81-7.61 (m, 4H), 7.44 (d, J = 7.2 Hz, 1H), 4.14-3.98 (m, 2H). 1-134 (Method L1): R.sub.t = 3.70 1H NMR (300 MHz, DMSO-d6) 9.32 (d, J = min; m/z = 498 (M H).sup. 2.3 Hz, 1H), 9.15-9.07 (m, 2H), 8.86 (t, J = 2.1 Hz, 1H), 8.37-8.28 (m, 2H), 7.92 (d, J = 8.2 Hz, 1H), 7.81-7.61 (m, 3H), 7.45 (d, J = 7.3 Hz, 1H), 4.22-7.00 (m, 2H). 1-137 (Method L1): R.sub.t = 3.20 1H NMR (300 MHz, DMSO-d6) 9.29 (t, J = min; m/z = 510 (M + H).sup.+ 6.0 Hz, 1H), 9.00 (d, J = 2.0 Hz, 1H), 8.81 (d, J = 4.0 Hz, 1H), 8.73 (d, J = 2.2 Hz, 1H), 8.46 (t, J = 2.1 Hz, 1H), 8.28 (d, J = 8.5 Hz, 2H), 7.91 (d, J = 7.3, 3.6 Hz, 2H), 7.79 (d, J = 7.8, 4.7 Hz, 1H), 4.23-4.02 (m, 2H). 1-138 (Method L1): R.sub.t = 3.07 1H NMR (300 MHz, DMSO-d6) 9.28 (t, J = min; m/z = 494 (M + H).sup.+ 6.1 Hz, 1H), 8.93 (d, J = 1.6 Hz, 1H), 8.81 (d, J = 4.0 Hz, 1H), 8.69 (d, J = 2.6 Hz, 1H), 8.34-8.22 (m, 3H), 7.92 (d, J = 7.3 Hz, 2H), 7.79 (d, J = 7.8, 4.7 Hz, 1H), 4.24-4.01 (m, 2H). 1-139 (Method L1): R.sub.t = 3.23 1H NMR (300 MHz, DMSO-d6) 9.29 (t, J = min; m/z = 510 (M + H).sup.+ 6.2 Hz, 1H), 8.89 (d, J = 2.6 Hz, 1H), 8.82 (d, J = 4.0 Hz, 1H), 8.34 (d, J = 8.4, 2.6 Hz, 1H), 8.24 (d, J = 6.9 Hz, 2H), 7.98-7.87 (m, 2H), 7.80 (d, J = 7.8, 4.7 Hz, 1H), 7.69 (d, J = 8.4 Hz, 1H), 4.25-4.03 (m, 2H). 1-140 (Method L1): R.sub.t = 3.14 1H NMR (300 MHz, DMSO-d6) 9.27 (t, J = min; m/z = 494 (M + H).sup.+ 6.2 Hz, 1H), 8.79 (d, J = 3.7 Hz, 1H), 8.70 (d, J = 2.5 Hz, 1H), 8.45 (t, J = 8.3, 2.7 Hz, 1H), 8.20 (d, J = 6.7 Hz, 2H), 7.90 (t, J = 7.0 Hz, 2H), 7.78 (d, J = 7.8, 4.7 Hz, 1H), 7.35 (d, J = 8.6, 2.8 Hz, 1H), 4.22-4.03 (m, 2H). 1-142 (Method L1): R.sub.t = 3.09 1H NMR (300 MHz, DMSO-d6) 9.21 (t, J = min; m/z = 460 (M + H).sup.+ 5.9 Hz, 1H), 8.83 (d, J = 15.1, 3.6 Hz, 2H), 8.28 (d, J = 8.4, 2.7 Hz, 1H), 7.93-7.83 (m, 2H), 7.82-7.64 (m, 4H), 4.23-4.08 (m, 2H). 1-143 (Method L1): R.sub.t = 2.99 1H NMR (300 MHz, DMSO-d6) 9.21 (s, 1H), min; m/z = 444 (M + H)+ 8.79 (d, J = 4.6 Hz, 1H), 8.66 (s, 1H), 8.40 (td, J = 8.2, 2.6 Hz, 1H), 7.89-7.64 (m, 5H), 7.34 (d, J = 8.6, 2.8 Hz, 1H), 4.24-4.03 (m, 2H). 1-146 (Method L1): R.sub.t = 3.27 1H NMR (300 MHz, DMSO-d6) 9.02 (t, J = min; m/z = 469 (M + H).sup.+ 6.3 Hz, 1H), 8.80 (s, 2H), 7.80-7.56 (m, 6H), 7.38 (d, J = 7.3 Hz, 1H), 4.18-4.01 (m, 2H), 3.18 (s, 6H). 1-147 (Method L1): R.sub.t = 3.33 1H NMR (300 MHz, DMSO-d6) 9.22 (s, 2H), min; m/z = 460 (M + H).sup.+ 9.05 (t, J = 6.3 Hz, 1H), 7.97 (d, J = 12.4 Hz, 1H), 7.87-7.60 (m, 5H), 7.38 (d, J = 7.4 Hz, 1H), 4.19-4.04 (m, 2H). 1-148 (Method L1): R.sub.t = 2.99 1H NMR (300 MHz, DMSO-d6) 9.29-9.14 min; m/z = 426 (M + H).sup.+ (m, 3H), 9.05 (t, J = 6.1 Hz, 1H), 7.96 (d, J = 12.4 Hz, 1H), 7.87-7.60 (m, 5H), 7.39 (d, J = 7.3 Hz, 1H), 4.21-4.04 (m, 2H). 1-149 (Method L1): R.sub.t = 3.48 1H NMR (300 MHz, DMSO-d6) 9.08 (t, J = min; m/z = 519 (M + H).sup.+ 6.1 Hz, 1H), 8.83 (s, 2H), 8.11 (d, J = 6.8 Hz, 2H), 7.72 (dq, J = 32.2, 8.3, 7.7 Hz, 4H), 7.44 (d, J = 7.5 Hz, 1H), 4.15-4.00 (m, 2H), 3.19 (s, 6H). 1-150 (Method L1): R.sub.t = 3.40 1H NMR (300 MHz, DMSO-d6) 9.26 (s, 2H), min; m/z = 510 (M + H).sup.+ 9.11 (t, J = 6.3 Hz, 1H), 8.34 (s, 1H), 8.30 (d, J = 8.4 Hz, 1H), 7.93 (d, J = 8.2 Hz, 1H), 7.81-7.62 (m, 3H), 7.44 (d, J = 7.4 Hz, 1H), 4.20-4.00 (m, 2H). 1-151 (Method L1): R.sub.t = 3.10 1H NMR (300 MHz, DMSO-d6) 9.28 (s, 3H), min; m/z = 476 (M + H).sup.+ 9.12 (t, J = 6.2 Hz, 1H), 8.37-8.25 (m, 2H), 7.93 (d, J = 8.2 Hz, 1H), 7.81-7.61 (m, 3H), 7.45 (d, J = 7.3 Hz, 1H), 4.11 (td, J = 14.5, 6.1 Hz, 2H). 1-152 (Method L1): R.sub.t = 2.76 1H NMR (300 MHz, DMSO-d6) 9.34-9.24 min; m/z = 477 (M + H).sup.+ (m, 4H), 8.81 (d, J = 3.9 Hz, 1H), 8.37-8.26 (m, 2H), 7.98-7.87 (m, 2H), 7.79 (d, J = 7.8, 4.7 Hz, 1H), 4.24-4.03 (m, 2H). 1-153 (Method L1): R.sub.t = 3.10 1H NMR (300 MHz, DMSO-d6) 9.32-9.22 min; m/z = 511 (M + H).sup.+ (m, 3H), 8.84-8.77 (m, 1H), 8.37-8.26 (m, 2H), 7.97-7.88 (m, 2H), 7.79 (d, J = 7.8, 4.5 Hz, 1H), 4.24-4.03 (m, 2H). 1-154 (Method L1): R.sub.t = 2.94 1H NMR (300 MHz, DMSO-d6) 9.27-9.15 min; m/z = 461 (M + H).sup.+ (m, 3H), 8.79 (d, J = 4.7 Hz, 1H), 7.97 (d, J = 12.4 Hz, 1H), 7.89-7.70 (m, 4H), 4.15 (td, J = 14.9, 6.6 Hz, 2H). 1-155 (Method L1): R.sub.t = 3.06 1H NMR (300 MHz, DMSO-d6) 9.21 (t, J = min; m/z = 460 (M + H).sup.+ 6.3 Hz, 1H), 8.97 (d, J = 1.9 Hz, 1H), 8.79 (d, J = 4.7 Hz, 1H), 8.70 (d, J = 2.2 Hz, 1H), 8.38 (t, J = 2.1 Hz, 1H), 7.98 7.65 (m, 5H), 4.15 (td, J = 14.4, 6.0 Hz, 2H). 1-156 (Method L1): R.sub.t = 2.92 1H NMR (300 MHz, DMSO-d6) 9.22 (t, J = min; m/z = 444 (M + H).sup.+ 6.1 Hz, 1H), 8.91 (d, J = 1.4 Hz, 1H), 8.80 (d, J = 4.7 Hz, 1H), 8.67 (d, J = 2.6 Hz, 1H), 8.26-8.17 (m, 1H), 7.98-7.67 (m, 5H), 4.16 (td, J = 14.6, 6.4 Hz, 2H). LC-MS Methods Method L1: MS instrument type: Agilent Technologies 6130 Quadrupole LC-MS; HPLC instrument type: Agilent Technologies 1260 Infinity; column: Waters XSelect (C18, 50 2.1 mm, 3.5); flow: 0.8 mL/min; column temp: 35 C.; eluent A: 0.1% formic acid in acetonitrile; eluent B: 0.1% formic acid in water; lin. gradient: t = 0 min 5% A, t = 3.5 min 98% A, t = 6 min 98% A; detection: DAD (220-320 nm); detection: MSD (ESI pos/neg) mass range: 100-800; detection: ELSD (PL-ELS 2100): gas flow 1.2 mL/min, gas temp: 70 C., neb: 50 C. Method L2: MS instrument type: Agilent Technologies LC/MSD SL; HPLC instrument type: Agilent Technologies 1100 Series; column: Waters XSelect (C18, 50 2.1 mm, 3.5; flow: 0.8 mL/min; column temp: 25 C.; eluent A: 95% acetonitrile + 5% ammoniumbicarbonate in water; eluent B: 10 mmM ammoniumbicarbonate in water pH = 9.0; lin. gradient: t = 0 min 5% A, t = 3.5 min 98% A, t = 6 min 98% A; detection: DAD (220-320 nm); detection: MSD (ESI pos/neg) mass range: 100-800. NMR spektra (Method M2) .sup.1H-instrument type: Bruker DMX300 (.sup.1H-NMR: 300 MHz); internal standard: tetramethylsilane; chemical shifts () are displayed in parts per million [ppm]; the following abbreviations are used: s = singlet, d = doublet, t = triplet, q = quartet, m = multiplet, br. = broad; coupling constants are displayed in Hertz [Hz].

BIOLOGICAL EXAMPLES

Haemonchus contortus (HAEMCO)

Assay

[0802] Solvent: dimethyl sulfoxide

[0803] To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with Ringer's solution to the desired concentration.

[0804] Approximately 40 larvae of the red stomach worm (Haemonchus contortus) are transferred into a test tube containing compound solution.

[0805] After 5 days percentage of larval mortality are recorded. 100% efficacy means all larvae are killed, 0% efficacy means no larvae are killed.

[0806] In this test for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 20 ppm: 1-33, 1-35, 1-37, 1-38, 1-39, 1-40, 1-42, 1-43, 1-44, 1-45, 1-47, 1-48, 1-53, 1-62, 1-66, 1-68, 1-69, 1-72, 1-73, 1-74, 1-75, 1-77, 1-78, 1-79, 1-80, 1-81, 1-82, 1-83, 1-84, 1-85, 1-86, 1-87, 1-88, 1-89, 1-90, 1-92, 1-93, 1-94, 1-96, 1-97, 1-98, 1-99, 1-100, 1-101, 1-102, 1-103, 1-106, 1-107, 1-111, 1-120, 1-122, 1-126, 1-127, 1-128.

[0807] In this test for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 20 ppm: 1-3, 1-5, 1-12, 1-14, 1-32, 1-41, 1-49, 1-67, 1-70, 1-71, 1-104, 1-110.

[0808] In this test for example, the following compounds from the preparation examples showed good activity of 80% at an application rate of 20 ppm: 1-1, 1-11, 1-16, 1-20, 1-27, 1-28, 1-56, 1-57, 1-58, 1-60, 1-64, 1-114, 1-121.

[0809] In this test for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 4 ppm: 1-15, 1-124.

Cooperia curticei (COOPCU)

Assay

[0810] Solvent: dimethyl sulfoxide

[0811] To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with Ringer's solution to the desired concentration.

[0812] Approximately 40 nematode larvae (Cooperia curticei) are transferred into a test tube containing the compound solution.

[0813] After 5 days percentage of larval mortality is recorded. 100% efficacy means all larvae are killed; 0% efficacy means no larvae are killed.

[0814] In this test for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 20 ppm: 1-9, 1-12, 1-14, 1-15, 1-16, 1-18, 1-19, 1-20, 1-21, 1-31, 1-32, 1-33, 1-34, 1-35, 1-37, 1-38, 1-39, 1-40, 1-41, 1-42, 1-43, 1-44, 1-45, 1-46, 1-47, 1-48, 1-49, 1-51, 1-52, 1-53, 1-55, 1-57, 1-58, 1-59, 1-60, 1-62, 1-64, 1-66, 1-68, 1-69, 1-70, 1-71, 1-72, 1-73, 1-74, 1-75, 1-77, 1-78, 1-79, 1-80, 1-81, 1-82, 1-83, 1-84, 1-85, 1-86, 1-87, 1-88, 1-89, 1-90, 1-91, 1-92, 1-93, 1-94, 1-96, 1-97, 1-98, 1-99, 1-100, 1-101, 1-102, 1-106, 1-146, 1-107, 1-110, 1-111, 1-114, 1-120, 1-122, 1-126, 1-127, 1-128.

[0815] In this test for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 20 ppm: 1-24, 1-26, 1-50, 1-65, 1-105, 1-124.

[0816] In this test for example, the following compounds from the preparation examples showed good activity of 80% at an application rate of 20 ppm: 1-1, 1-13, 1-23, 1-27, 1-28, 1-36, 1-56, 1-121, 1-125.

[0817] In this test for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 4 ppm: 1-104.

[0818] In this test for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 4 ppm: 1-67, 1-149

Nippostrongylus brasiliensis (NIPOBR)

Assay

[0819] Adult Nippostrongylus brasiliensis were washed with saline buffer containing 100 U/ml penicillin, 0.1 mg/ml streptomycin and 2.5 g/ml amphotericin B. Test compounds were dissolved in DMSO and worms were incubated in medium in a final concentration of 10 g/ml (10 ppm). An aliquot of the medium was used to determine the acetylcholine esterase activity in comparison to a negative control. The principle of measuring acetylcholine esterase as readout for anthelmintic activity was described in Rapson et al (1986) and Rapson et al (1987).

[0820] For the following examples, activity (reduction of AChE compared to negative control) was 60% or higher at 10 ppm:

1-1; 1-9; 1-33; 1-37; 1-44; 1-45; 1-48; 1-49; 1-53; 1-68; 1-69; 1-70; 1-73; 1-74; 1-75; 1-77; 1-78; 1-82; 1-87; 1-88; 1-89; 1-90; 1-92; 1-93; 1-96; 1-97; 1-98; 1-99; 1-100; 1-101; 1-106; 1-107; 1-111

[0821] For the following examples, activity (reduction of AChE compared to negative control) was higher than 80% at 10 ppm: 1-1, 1-33, 1-37, 1-45, 1-53, 1-68, 1-69, 1-70, 1-73, 1-74, 1-77, 1-82, 1-93, 1-96, 1-97, 1-99, 1-100, 1-106, 1-107, 1-111.

Meloidogyne incognita (MELGIN)

Assay

[0822] Solvent: 125.0 parts by weight of acetone

[0823] To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent, and the concentrate is diluted with water to the desired concentration.

[0824] Vessels are filled with sand, a solution of the active ingredient, a suspension containing eggs and larvae of the southern root-knot nematode (Meloidogyne incognita) and salad seeds. The salad seeds germinate and the seedlings grow. Galls develop in the roots.

[0825] After 14 days the nematicidal activity is determined on the basis of the percentage of gall formation. 100% means no galls were found and 0% means the number of galls found on the roots of the treated plants was equal to that in untreated control plants.

[0826] In this test, for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 20 ppm: 1-39, 1-47, 1-69, 1-70, 1-73, 1-81, 1-82, 1-85, 1-86, 1-87, 1-88, 1-89, 1-93, 1-94, 1-104, 1-120, 1-128, 1-129, 1-130.

[0827] In this test, for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 20 ppm: 1-16, 1-19, 1-20, 1-24, 1-37, 1-42, 1-44, 1-48, 1-66, 1-68, 1-74, 1-80, 1-106, 1-126, 1-136, 1-140.

In Vivo Efficacy Test

[0828] Haemonchus contortus/Trichostrongylus colubriformis/gerbil

[0829] Gerbils, experimentally infected with Haemonchus and/or Trichostrongylus, were treated once during late prepatency. Test compounds were formulated as solutions or suspensions and applied intraperitoneally or subcutaneously.

[0830] Efficacy was determined per group as reduction of worm count in stomach and small intestine, respectively, after necropsy compared to worm count in an infected and placebo-treated control group.

[0831] The following examples were tested and had an activity of 90% or higher after intraperitoneal treatment at the given dosage:

TABLE-US-00005 Treatment Haemonchus Trichostrongylus 20 mg/kg 1-69; 1-78; 1-96 1-69 intraperitoneally 20 mg/kg 1-93 1-93 subcutaneously

In Vitro Efficacy Test

[0832] In vitro assay targeting Dirofilaria immitis microfilariae

[0833] 250 Dirofilaria immitis microfilariae, which were freshly purified from blood, were added to wells of a microtitre plate containing a nutrient medium and the test compound in DMSO. Compounds were tested in a five point concentration-response assay in duplicate. Larvae exposed to DMSO and no test compounds were used as negative controls. Larvae were evaluated after 72 h of incubation with the compound. Efficacy was determined as the reduction of motility in comparison to the negative control. Based on the evaluation of five concentrations, concentration-response curves as well as EC.sub.50-values were calculated.

[0834] For the following examples, the EC50 was <5 ppm: 1-70; 1-73; 1-74; 1-77; 1-78; 1-89; 1-93; 1-99; 1-100; 1-101

[0835] For the following examples, the EC.sub.50 was <2.5 ppm: 1-93

COMPARATIVE EXAMPLES

Haemonchus contortus-Test (HAEMCO)

[0836] Solvent: dimethyl sulfoxide

[0837] To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with Ringer's solution to the desired concentration.

[0838] Approximately 40 larvae of the red stomach worm (Haemonchus contortus) are transferred into a test tube containing compound solution.

[0839] After 5 days percentage of larval mortality are recorded. 100% efficacy means all larvae are killed, 0% efficacy means no larvae are killed.

[0840] In this test, for example, the following compounds from the preparation examples show a superior level of activity compared to the prior state of the art: see following table 4.

TABLE-US-00006 TABLE 4 % Substance Structure Object Concentration Efficacy dat Ex.-No. 1-49 Known from WO2012/118139 [00288] HAEMCO 20 ppm 4 ppm 0.8 ppm 80 60 60 5 dat 5 dat 5 dat Ex.-No. 1-37 According to the invention [00289] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat Ex.-No. 1-38 According to the invention [00290] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat Ex.-No. 1-43 According to the invention [00291] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat Ex.-No. 1-44 According to the invention [00292] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat Ex.-No. 1-45 According to the invention [00293] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat Ex.-No. 1-47 According to the invention [00294] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 80 5 dat 5 dat 5 dat Ex.-No. 1-48 According to the invention [00295] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 80 5 dat 5 dat 5 dat Ex.-No. 1-35 According to the invention [00296] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 90 80 5 dat 5 dat 5 dat Ex.-No. 1-62 According to the invention [00297] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 90 80 5 dat 5 dat 5 dat Ex.-No. 1-69 According to the invention [00298] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat Ex.-No. 1-74 According to the invention [00299] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat Ex.-No. 1-93 According to the invention [00300] HAEMCO 20 ppm 4 ppm 0.8 ppm 100 100 100 5 dat 5 dat 5 dat