MEDICAL CONTACT SHOCK FREEZER

Abstract

A medical contact shock freezer adapted for fast freezing a plurality of individual bags containing a medical liquid has the contact surface of its upper freezing plate arranged at an angle of at least 2° to the horizontal.

Claims

1-15. (canceled)

16. A medical contact shock freezer adapted for fast freezing a plurality of individual bags containing a medical liquid, the individual bags being arranged side by side, adjacent to each other, in which the contact shock freezer comprises a pair of freezing plates comprising an upper freezing plate and a lower freezing plate; in which one of the upper and lower freezing plates of the pair of freezing plates is a fixed freezing plate which is fixed and does not move; in which the other one of the upper and lower freezing plates of the pair is a moveable freezing plate which is moveable to define i) a loading position in which sufficient separation is provided between the freezing plates to load or unload the individual bags between the freezing plates and ii) a freezing position in which each individual bag is in contact with and is clamped between a contact surface of the upper freezing plate and a contact surface of the lower freezing plate; in which the contact surfaces of the upper and lower freezing plates of the pair of freezing plates are parallel in their freezing position and remain parallel during movement between the loading and the freezing position; in which, in its freezing position, the contact surface of the upper freezing plate is arranged at an angle which is ≥2° and ≤30° with respect to the horizontal; wherein movement between the loading and freezing position of the pair of freezing plates consists of a linear, vertical displacement of the movable freezing plate.

17. A medical contact shock freezer in accordance with claim 16, in which the shock freezer comprises a first pair of upper and lower freezing plates and a second pair of upper and lower freezing plates, the first pair being arranged above the second pair; in which the first pair of upper and lower freezing plates comprises an immobile lower freezing plate and a moveable upper freezing plate; in which the second pair of upper and lower freezing plates comprises an immobile upper freezing plate and a moveable lower freezing plate; and in which, in its freezing position, the contact surface of each of the upper freezing plates is arranged at an angle which is ≥2° and ≤30° with respect to the horizontal.

18. A medical contact shock freezer in accordance with claim 17, in which the lower freezing plate of the first pair of freezing plates and the upper freezing plate of the second pair of freezing plates are provided by a single, integrated freezing plate.

19. A medical contact shock freezer in accordance with claim 16, in which in its freezing position, the contact surface of the upper freezing plate is arranged at an angle of between 3° and 10° to the horizontal.

20. A medical contact shock freezer in accordance with claim 16, in which the contact surface of the upper freezing plate and the contact surface of the lower freezing plate are each planar contact surfaces.

21. A medical contact shock freezer in accordance with claim 16, in which the pair of freezing plates defines an operating surface which has: a width that is ≥0.4 m and ≤1.6 m; and a depth that is ≥0.5 m and ≤1.1 m.

22. A medical contact shock freezer in accordance with claim 16, in which each freezing plate is configured to operate at a temperature which is ≤−50° C.

23. A medical contact shock freezer in accordance with claim 16, in which, in their freezing position, the contact surface of the upper freezing plate and the contact surface of the lower freezing plate are each arranged at an angle of about 5° to the horizontal.

24. A method of shock freezing a plurality of individual bags containing a medical liquid, wherein the method comprises: arranging the individual bags side by side, adjacent to each other between the upper freezing plate and the lower freezing plate of a contact shock freezer in accordance with claim 1 with the plates arranged in a bag loading position; subsequently closing the freezing plates to the freezing position by moving the moveable freezing plate to clamp each individual bag in contact with the contact surface of the upper freezing plate and the contact surface of the lower freezing plate with each individual bag being held in an angled bag configuration at an angle which is ≥2° and ≤30° with respect to the horizontal, and in which closing the freezing plates to the freezing position by moving the moveable freezing plate to clamp each individual bag in contact with the contact surface of the upper freezing plate and the contact surface of the lower freezing plate consists of displacing the moveable freezing plate linearly and vertically; subsequently freezing the medical liquid in each individual bag to a temperature of −20° C. or below through heat exchange between the medical liquid and the upper and lower freezing plates; subsequently moving the moveable freezing plate to its loading position and removing the frozen bags from the shock freezer.

25. A method in accordance with claim 24, in which each individual bag is held in an angled bag configuration at an angle of between 3° and 10° to the horizontal.

26. A method in accordance with claim 25, in which each individual bag is held in its angled bag configuration due to angling of the contact surfaces of its upper and lower freezing plates.

27. A method in accordance with claim 24, in which each bag holds a medical liquid selected from blood plasma, a biological preparation and a pharmaceutical preparation.

28. A method in accordance with claim 24, in which freezing the medical liquid in each individual bag comprises freezing each bag from a temperature of between 15° C. and 25° C. to a temperature of −25° C. or below.

29. A method in accordance with claim 28, in which the freezing is accomplished in a freezing time of 60 minutes or less.

30. A method in accordance with claim 24, in which the individual bags are selected from i) bags containing between about 150 ml and 450 ml of blood plasma and ii) bags containing between about 750 ml and 950 ml of blood plasma.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0023] An embodiment of the invention will now be described, by way of example only, with reference to the accompanying drawings, of which:

[0024] FIG. 1 is schematic front view of a shock freezer with its freezing plates in their loading position;

[0025] FIG. 2 is a schematic front view of the shock freezer with its freezing plates in their freezing position; and

[0026] FIG. 3 is a schematic side view of the freezing plates in their freezing position.

DETAILED DESCRIPTION

[0027] The illustrated contact shock freezer 10 comprises: a first pair 11 of upper 21 and lower 22 freezing plates; and a second pair 12 of upper 31 and lower 32 freezing plates; the first pair 11 being arranged above the second pair 12. The lower freezing plate 22 of the first pair of freezing plates 11 and the upper freezing plate 31 of the second pair of freezing plates 12 are provided by a single, immobile, integrated freezing plate 13.

[0028] In use, with each pair 11, 12 of freezing plates in its loading position (FIG. 1), a first series of plasma bags to be frozen is arranged in rows (the front bag 41, 42, 43 of each row being illustrated in FIG. 1) between the upper 21 and lower 22 freezing plates of the first pair of freezing plates 11 by being placed on an operating surface provided by the lower freezing plate 22 by an operator standing in front of the freezer 10. A second series of plasma bags to be frozen is similarly arranged in rows (the front bag 51, 52, 53 of each row being illustrated in FIG. 1) between the upper 31 and lower 32 freezing plates of the second pair of freezing plates 12 by being placed on an operating surface provided the lower freezing plate 32 by an operator standing in front of the freezer 10. Each pair 11, 12 of freezing plates is then moved from its loading position (FIG. 1) to its freezing position (FIG. 2) in the following way: the upper freezing plate 21 of the first pair of freezing plates 11 is moved vertically downwards by a pair of vertically arranged hydraulic cylinders 61, 62 arranged at the left side 61 and right side 62 of the upper freezing plate to clamp the first series of plasma bags to be frozen between a contact surface 23 of the upper freezing plate 21 and a contact surface 24 of the lower freezing plate 22; and the lower freezing plate 32 of the second pair 12 of freezing plates is moved vertically upwards by a pair of vertically arranged hydraulic cylinders 63, 64 arranged at the left side 63 and right side 64 of the lower freezing plate 32 to clamp the second series of plasma bags to be frozen between a contact surface 33 of the upper freezing plate 31 and a contact surface 34 of the lower freezing plate 32. In the freezing position (FIG. 2), with the plasma bags 41, 42, 43, 51, 52, 53 clamped between their respective freezing plates, the plasma in the bags is frozen from a temperature of about 20° C. to a temperature of −30° C. in a time of about 40 minutes. Once the plasma bags have been frozen, each pair of freezing plates 11, 12 is moved from its freezing position (FIG. 2) to its loading position (FIG. 1) and the plasma bags are removed by an operator standing at the front of the shock freezer 10 and placed in cold storage.

[0029] The illustrated contact shock freezer 10 is shown schematically with nine plasma bags arranged between each pair 11, 12 of freezing plates. The first pair 11 of freezing plates 11 has three lines of plasma bags arranged across its width (of which the front bag 41, 42, 43 of each line is illustrated in FIG. 1 and FIG. 2) and three lines of plasma bags arranged across its depth (of which the left side bag 41, 44, 47 of each row is illustrated in FIG. 3). The illustrated arrangement for the second pair 12 of freezing plates is similar. Flattening and compression of the plasma bags in the freezing position is schematically illustrated in FIG. 2.

[0030] Contact surfaces 23, 24 of the first pair 11 of freezing plates 21, 22 are each planar and parallel to each other and are arranged to slope upwardly from the front 71 to the rear 72 of the shock freezer 10 at an angle α to the horizontal. Similarly, contact surfaces 33, 34 of the second pair 12 of freezing plates 31, 32 are each planar and parallel to each other and are arranged to slope upwardly from the front 71 to the rear 72 of the shock freezer 10 at an angle α to the horizontal. The angle α is preferably between about 2° and about 10°, for example about 5° but has been shown in an exaggerated fashion in FIG. 3 for illustrative purposes.

[0031] As shown in FIG. 3, each bag is held in an angled bag configuration at an angle α to the horizontal, that is to say, a plane passing centrally through each bag with respect to its upper and lower walls has an angle α to the horizontal.