Composition in form of a gel for the virucidal disinfection of mammalian skin

Abstract

The present invention describes a composition in form of a gel for the virucidal disinfection of mammalian skin comprising 71 to 95 weight percent of a C1 to C3 monoalcohol, 0.01 to 1 weight percent thickener and wherein the composition has a viscosity range of from 3000 to 19000 mPas measured at 20 C. with spindle LV3 at a speed of 2.5 rpm. Furthermore, the invention describes a method for virucidal disinfection of skin.

Claims

1. Composition in form of a gel for the virucidal disinfection of mammalian skin comprising: 85 to 95 wt-% of a C1 to C3 monoalcohol, 0.01 to 0.4 wt-% of thickener comprising an acrylate, wherein the thickener results in the composition having a viscosity in the range from 3000 to 9000 mPas measured at 20 C. with spindle LV3 at a speed of 2.5 rpm, and a neutralizer comprising tetrahydroxypropylethylendiamine in an amount that results in a pH of 6 to 8, wherein the composition is free of virucidal enhancers selected from percarboxylic acid, inorganic acid, aldehydes, organic C1 to C10 acid, and aminoxides; and wherein the composition is capable of inactivation of one or more non-enveloped viruses by at least 4 log.sub.10 within two minutes or less.

2. Composition according to claim 1, wherein the composition is formulated for use for the virucidal disinfection of hands.

3. Composition according to claim 1, wherein the composition is capable of inactivation of poliovirus (type 1, strain LSc-2ab) and adenovirus (type 5, strain Adenoid 75).

4. Composition according to claim 1, wherein the composition is capable of inactivating poliovirus and adenovirus by greater than or equal to 4 log.sub.10 units in less than or equal to 2 min contact time.

5. Composition according to claim 1, wherein the C1 to C3 monoalcohol is selected from the group consisting of methanol, ethanol and 2-propanol or mixtures thereof.

6. Composition according to claim 1, wherein the C1 to C3 monoalcohol comprises ethanol, and wherein the composition can contain up to 30 wt-% of other C1 to C3 alcohols.

7. Composition according to claim 1, wherein the concentration of the thickener is 0.1 to 0.4 wt-%.

8. Composition according to claim 1, wherein the viscosity is in a range of from 5000 to 9000 mPas.

9. Composition according to claim 1, wherein the thickener is selected from the group consisting of a polyacrylic acid, a polyacrylate, a copolymer of a polyacrylic acid and a polyacrylic acid alkylester, a copolymer of a polyacrylate and a polyacrylic acid alkyl ester.

10. Composition according to claim 1, wherein the composition has a pH of 5 to 8.

11. Method for virucidal disinfection of mammalian skin comprising: contacting the skin with the composition of claim 1 for at most 2 min to inactivate the virus titre for at least 4 log.sub.10 units.

12. The composition of claim 1, wherein the thickener comprises polyacrylic acid or copolymer of polyacrylic acid and the composition further comprises an alkanolamine, alkylamine, or combination thereof.

Description

(1) The following examples further illustrate the invention.

EXAMPLES

Example 1

Preparation of the Composition

(2) 0.230 gram of the thickener was added to 6.0445 gram of water and thoroughly mixed to obtain a homogenous dispersion. Then, 86.575 gram of ethanol (96 percent V/V Ph.Eur.grade) was added to the mixture and stirred until homogenous. To the solution 2.9475 gram of skin care ingredients and emollients were added and mixed for further 10 minutes. To reach the final viscosity 0.378 gram of tetrahydroxypropylethylendiamine as neutralizer dissolved in 3.825 gram ethanol (96 percent V/V Ph. Eur. grade) was added and the solution stirred until the system became homogenous. The viscosity of the composition was measured acc DIN 53019 with a Brookfield Digital Viscometer LVDV-II+ at 20 C., spindle LV3, speed 2.5 rpm at 8200 mPas.

(3) In the same way further virucidal compositions according to the invention were prepared. The viscosity of the examples was measured as described above. The inactivation of the test viruses poliovirus and adenovirus was measured according to the procedure described in European standard EN14476 (2005). The following table 1 shows the results.

(4) In table 1 examples 1, 2 and 3 are examples according to the invention all with an ethanol concentration of 85% w/w and with different viscosities. Comparative example 4 is an example having a higher viscosity of 20252 mPas measured as described before. Comparative example 5 is an example only with ethanol without any thickener.

(5) TABLE-US-00001 TABLE 1 Comparative Comparative Example 1 Example 2 Example 3 Example 4 Example 5 Description Quantity in % w/w Quantity in % w/w Quantity in % w/w Quantity in % w/w Quantity in % w/w Water, deionized 11.4445 11.3285 11.4735 11.0875 12.0525 Thickener system 0.230 0.2740 0.2190 0.3650 Ethanol, denatured 85.0000 85.0000 85.0000 85.0000 85.0000 Skin Care ingredients and Emollients 2.9475 2.9475 2.9475 2.9475 2.9475 Neutralizer 0.378 0.4500 0.3600 0.6000 (Tetrahydroxypropylethylendiamine) pH measured at 20 C. 10% solution in 7.6 7.6 7.5 7.5 7.6 water Brookfield Digital Viscometer 8200 9900 5900 20250 0 LVDV-II + [mPas]; spindle LV3, speed 2.5 rpm, T = 20 C. Reduction of Adeno* acc to pass pass pass failed pass EN 14476, contact time 2 min >log.sub.10 4.86 >log.sub.10 4.43 >log.sub.10 5.43 log.sub.10 1.57 >log.sub.10 4.43 Reduction of Polio** acc to EN 14476, pass pass pass failed pass contact time 2 min >log.sub.10 4 >log.sub.10 4 >log.sub.10 4 <log.sub.10 1.71 >log.sub.10 4 Virucidal acc to EN 14476, contact time pass pass pass failed pass 2 min *Adeno virus type 5, strain adenoid 75, ATCC VR-5 **Polio virus type 1, LSc-2ab

(6) From the tables can be seen that the compositions according to the invention which are shown in examples 1, 2, 3 having a viscosity in the range of 5900 to 9900 all show a virus inactivation of at least 4 log.sub.10 units after 2 minutes contact time. The pH of the examples was measured in a 10% water solution. It can be seen that the composition according to the invention is neutral which means that it is very skin friendly even if used frequently.

(7) In contrast the comparative example 4 which is an alcoholic gel of the state of the art having a higher viscosity of 20250 mPas showed a virus titer reduction of adenovirus of only 1.57 log.sub.10 units and of poliovirus of only 1.71 log.sub.10 and therefore failed the virucidal test according to EN 14476 after a contact time of two minutes. Comparative example 5 is an example only comprising ethanol and water with skin care agents without a thickener system. It can be seen that if the viscosity is zero the adenovirus and poliovirus are also inactivated and the virucidal composition passes.