System and method for incorporating CBD/THC cannabinoid nanoparticle carrier compositions into particulate foods and food additives

Abstract

A method of producing a cannabinoid nanoparticle carrier composition for administration to a human and thereafter producing a consumable food product including the cannabinoid nanoparticle emulsification. The cannabinoid nanoparticle carrier composition is combined with a particulate food product, herb or spice, sugar, salt, or particulate preservative, mixed into a slurry or suspension, dried, and then ground to a size suitable for human consumption.

Claims

1. A method of incorporating a cannabinoid nanoparticle carrier composition in particular foods and food additives, comprising: (a) mixing non-ionic surfactants with cannabinoid oils and lipids in a mixing vessel wherein the non-ionic surfactants, cannabinoid oils, and lipids, respectively, are mixed in proportions of 5.9:9 by weight of a total formula weight of the cannabinoid nanoparticle carrier composition; (b) processing the mixture made in step (a) using sonication for a predetermined time at a predetermined amplification until completely processed and substantially all of the cannabinoid oils are reduced to nanoparticle size in a cannabinoid oil complex (COC); (c) dissolving ascorbic acid in a carrier fluid to make an acidic carrier fluid solution, wherein the ascorbic acid is in a relative amount of 0.01-3% by weight of the total formula weight of the cannabinoid nanoparticle carrier composition; (d) mixing the COC made in steps (a) and (b) with the acidic carrier fluid solution made in step (c); (e) sonicating the mixture made in step (d) using an ultrasonic liquid processor operated at a predetermined amplitude for a predetermined time at a controlled temperature until substantially all of the cannabinoid oils in step (d) are returned to nanoparticle size to complete the process of making the cannabinoid nanoparticle carrier composition; (f) combining the cannabinoid nanoparticle carrier composition with a consumable particulate food product or food additive selected from the group consisting of herbs and spices, flavorings, seasonings, salts, sugars, and particular food preservatives, or any combination thereof; (g) blending the combination made in step (f) to make a slurry or suspension; (h) drying the slurry or suspension is evaporated or dried to a solid state; and (i) reducing the dried product to a nominal particle mass size suitable for human consumption.

2. The method of claim 1, wherein approximately 5 grams of a particulate herb, spice, flavoring, salt, sugar, preservative, or the like, are combined with 1 gram of a stable cannabinoid nanoparticle carrier composition.

3. The method of claim 1, wherein the drying step (h) is completed using an industrial food production drying process, spray drying, drum drying, vacuum band drying, tray drying, or tunnel drying.

4. The method of claim 1, wherein step (i) includes grinding pulverizing the dried product from step (h).

5. The method of claim 1, wherein step (i) includes using salt or sugar particle size as a datum reference.

6. The method of claim 1, wherein said step (a) mixing step comprises mixing approximately 5000 mg of non-ionic surfactants with approximately 9000 mg of cannabinoid oils, and approximately 9000 mg lipids.

7. The method of claim 1, wherein said step (b) processing step comprises inducing sonication for approximately 90 seconds at 60% amplification.

8. The method of claim 7, wherein said step (b) processing step involves using an ultrasonic liquid processor.

9. The method of claim 1, wherein said step (c) comprises dissolving approximately 1000 mg of ascorbic acid into a carrier fluid to make an acidic carrier fluid solution.

10. The method of claim 9, wherein said carrier fluid is selected from the group consisting of distilled water, glycerides, and lipids, and mixtures thereof.

11. The method of claim 10, wherein the acidic carrier fluid solution comprises approximately 76 g distilled water and 1 g (1000 mg) ascorbic acid.

12. The method of claim 11, wherein step (e) involves sonicating at 60% using ultrasonic liquid processor.

13. The method of claim 12, wherein the sonication of step (e) is conducted at 60% amplitude.

14. The method of claim 13, wherein the sonication of step (e) is continued for approximately 5 minutes.

15. The method of claim 14, wherein the sonication is carried out at a constant 24 C. temperature.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) The inventive is first directed to a method of producing a cannabinoid nanoparticle carrier composition for therapeutic use, wherein the cannabinoid carrier composition improves bioavailabilty of the cannabinoids in the composition, as well as improves accurate dosing, due to the more precise measure. Various means of administration may be employed, including intraoral administration, peroral administration, transdermal administration, or intranasal administration. An exemplary composition produced by the inventive method may contain: (1) firstly, 1-15% Cannabinoids: Comprising of at least one of the Phytocannabinoids found in cannabis that include delta-9-Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinol (CBN) Cannabigerol (CBG}, Cannabigerol {CBG), Cannabichromene (CBC), Cannabicyclol (CBL), Canabivarol (CBV), Tetrahydrocannabiverin (THCV), Cannabidivarin (CBDV), Cannabichromevarin (CBCV, Cannabigerol Monoethyi ether (CBGM); (2) secondly, 1-20% Lipids (medium chain triglycerides, glycerides, hemps seed oil, safflower oil, sunflower oil, olive oil, etc.); and (3) thirdly, 1-10% pharmaceutical food grade surfactants (SpanLipophilic), (Tween-hydrophilic, e.g, as Tween 80, E433), to function as emulsifiers. They may be used independently or in any combination of the following: 20, sorbitan monopalmitate; Span 40, sorbitan monopalmitate; Span 60, sorbitan monostearate; and Span 80, sorbitan monooleate). Tween are hydrophilic, Span are lipophilic. [TWEEN is a registered trademark of Croda Americas LLC of Bridgewater, New Jersey; SPAN is a registered trademark of Merck KGaA of Darmstadt, Germany.]

(2) An exemplary non-limiting method of making the inventive composition entails the following steps, wherein the steps are non-limiting in the relative proportions of the composition components and recited amounts are understood to be close approximations:

(3) (1) Mixing 5000 mg of non-ionic surfactants with 9000 mg of cannabinoid oils, and 9000 mg lipids in a mixing vessel, e.g., a 200 ml beaker.

(4) (2) Inducing sonication for 90 seconds at 60% amplification with a ultrasonic liquid processor until completely integrated.

(5) (3) Dissolving 1000 mg of ascorbic acid into a carrier fluid selected from the group consisting of distilled water, glycerides, lipids, or a mixture thereof.

(6) (4) Combining in sequence the non-ionic surfactants, lipids, and cannabanoid oil complex (COC) with the carrier fluid/ascorbic acid solution, which may consist of 76 g distilled water and 1000 mg ascorbic acid.

(7) (5) Sonicating at 60% using ultrasonic liquid processor at 60% amplitude for 5 minutes, at a constant 24c temperature. The final weight of this exemplary nanoemulsion is 11.0 g at 100 ml.

(8) The following protocol applies: The ingredients are processed using a single or dual phase process utilizing sonication or ultrasonic processes for a determined period of time to produce a water-soluble nanoemulsion.

(9) The formula consists of: (a) non-ionic TWEEN or SPAN pharmaceutical food grade surfactants in specific combination or percentages to acquire 1-10% total surfactants; (b) refined olive oil 1 to 20%; (c) ascorbic acid 0.01-3%; (d) THC or CBD cannabinoids in any form of hemp or any classification form in any combination, whether concentration quantity or potency, 1-15%, in specific combinations; and (e) to achieve 100% of total formula weight or volume, the remaining ingredient is distilled water alone.

(10) Importantly, the inventive composition does not include lecithin or lecithin-based essential phospholipids. Rather, it involves the use of sonication or ultrasonic processing of the water-immiscible mixture to achieve the nanoemulsion.

(11) Next, the inventive process includes means of combining the cannabinoid nanoparticle carrier composition with any of a number of particulate food products, food additives, herbs and spices, flavorings, seasonings, salts, sugars, and monosodium glutamate.

(12) Approximately 50 grams of a particulate herb, spice, flavoring, salt, sugar, preservative, or the like, are combined with 10 grams of a stable CBD/THC concentrate/emulsification made by the process set out, above. The ingredients are combined and blended to make a slurry or suspension, and the slurry or suspension is evaporated or dried to a solid state using an industrial food production drying process, spray drying, drum drying, vacuum band drying, tray drying, tunnel drying, and so on. The preferred process is spray or drum drying.

(13) The dried product is then ground or pulverized to a nominal particle mass size using salt or sugar particle size as a datum reference. The resulting product is a CBD/THC particulate food product, food additive, herb, spice, salt, sugar, or preservative.

(14) The above disclosure is sufficient to enable one of ordinary skill in the art to practice the invention, and provides the best mode of practicing the invention presently contemplated by the inventor. While there is provided herein a full and complete disclosure of the preferred embodiments of this invention, it is not desired to limit the invention to the exact construction, dimensional relationships, and operation shown and described. Various modifications, alternative constructions, changes and equivalents will readily occur to those skilled in the art and may be employed, as suitable, without departing from the true spirit and scope of the invention. Such changes might involve alternative materials, components, structural arrangements, sizes, shapes, forms, functions, operational features or the like.

(15) Therefore, the above description and illustrations should not be construed as limiting the scope of the invention, which is defined by the claims included herein.