INTEGRAL SYSTEM OF ORTHOVOLTAGE SOURCES THAT INDUCE IONISING RADIATION

Abstract

The invention relates to a system for detecting, obtaining images and treating or eliminating tumours, diseases or other anomalies, which is excited by means of X-rays biomarked with metallic nanoparticles and which comprises an external support structure (600) with a shield, which comprises: a confocal system (1000) comprising a shielded external structure (67, 75) that contains a convergent scan X-ray device (100), a detection system (200) for X-ray photons with collimators that are solidly connected to and confocal with the first device, a second convergent treatment device (300) solidly connected to the confocal structure (100 and 200), and a supporting structure (400) that contains the convergent scan X-ray device (100), the detection system (200) and the second convergent treatment device (300), which project to a single focal point, and which ensures that same are confocal; a controlled 3D scanning structure (500) that moves a bed and/or focal point onto which ionising radiation is concentrated; an electronic control system comprising programmable electronics (700) that allow the operation of the convergent beam device, the operation of the sensors (2) and the movements of the 3D scanning system; and a computed tomography (CT) device (2000) comprising collimators, an X-ray tube and sensors and which is incorporated into the structure (600). The invention further relates to an associated method.

Claims

1. System for detecting, obtaining images and treating or eliminating neoplasms, pathologies or other anomalies, which is excited through X-rays biomarked with metallic nanoparticles, characterized in that the system comprises: an external support structure 600 with shielding comprising: A. a confocal system (1000) comprising a shielded external structure (67, 75), which inside comprises: a scanning X-ray convergent device (100), a detection system (200) for X photons with collimators solidary and confocal to the first device, a second convergent processing device (300) solidary to the same confocal structure (100 and 200) and a supporting structure (400) containing the scanning X-ray convergent device (100), the detection system (200) and the second convergent processing device (300), which project to a single focal point and which ensures that they are confocal; B. a controlled 3D scanning structure (500) moving a stretcher and/or focal point where the ionizing radiation is concentrated; C. an electronic control system comprising; a programmable electronics (700) allowing the operation of the convergent beam device, the operation of the detectors (2) and the movements of the 3D scanning system; and D. a computerized tomography CT (2000) comprising collimators, X-ray tube and detectors is incorporated in the same structure (600).

2. The system for detecting, imaging and treating neoplasms according to claim 1, characterized in that it has a large confocal system (1000) of at least 100 cm.sup.3 or more disposed of three essential elements. (100, 200, 300) (FIG. 1).

3. The system for detecting, imaging and treating neoplasm according to claims 1 and 2 characterized in that it has a vacuum static cylindrical convergent ionizing radiation scanning device (100), consisting of an electron gun (1), a beam braker (2), a white metallic cylinder 3 of high Z (>50) covered by a cylinder of a conductive material (Al or Cu) (4), a spherical cap (5) as a collimator with separate collimation holes 6 pointing to a focal point and confocal laser guides (7) (FIG. 2).

4. The system for detecting, imaging and treating neoplasm according to claims 1 and 2 characterized in that it has a dynamic convergent ionizing radiation scanning device (150), consisting of a rotating support arc (8) with shaft (9), bearings (10), bar (11) with confocal laser guides (7), X-ray tube (12), collimator (13) and counterweight (14) at one of its ends, rotating by means of a reduction and connection system (53) and an electric motor (52), the X-ray output is collimated by means of a collimator 13 that points to the focal point of the system 150 (FIG. 3).

5. The system for detecting, imaging and treating neoplasm according to claims 1 and 3 characterized in that the device consists of a curved anode cylinder (110) (FIG. 4) or a curved anode ring (120) (FIG. 5) or by a long curved anode cylinder (130) (FIG. 6).

6. The system for detecting, imaging and treating neoplasm according to claims 1 and 4 characterized in that it has a support structure (8, 24) with position adjustment means (19, 20, 22, 27) that allow fixing the X-ray tube (12) with the direction of its collimated output pointing towards the focal point and its projection is perpendicular to the tangent line of the arc intersecting it, the angle of the convergent cone is generated in preset positions without changing the position of the focal point (FIGS. 7 a 13).

7. The system for detecting, imaging and treating neoplasm according to claims 1, 4 and 6 characterized in that the support structure is selected from a supporting arch (8) or a straight arm (24) with center at the focal point.

8. The system for detecting, imaging and treating neoplasm according to claims 1, 4 and 6 characterized in that the position adjustment means are selected from positional holes (19), a long curved slot (20), a curved toothed slot (22) or a straight toothed slot (27) allowing the angle of the convergent cone to be varied.

9. The system for detecting, imaging and treating neoplasm according to claim 6, 7 or 8 characterized in that it further comprises an electric motor (23) allowing the angle of the convergent cone to be varied in a continuous mode, and two other motors (23) moving the X-ray tube 12 together with the counterweight 14 in opposite directions along the C-arc respectively (FIG. 9).

10. The system for detecting, imaging and treating neoplasm according to claim 6 or 7 characterized in that the support structure comprises an angular fixation (25) and an angular electric motor (26) for varying the angle of the convergent cone (FIG. 10, 12).

11. The system for detecting, imaging and treating neoplasm according to claim 6 or 7, characterized in that the support structure is attached to the system by means of the shaft (9), the straight arm 24 has a straight toothed slot (27) along the arm with shaft (9) and an electric motor allowing to vary the angle of the convergent cone (28) in a continuous way, and two other motors (23) moving the X-ray tube together and the compensator in opposite directions along the arm respectively (FIG. 13).

12. The system for detecting, imaging and treating neoplasm according to claim 1, characterized in that it has a confocal detection system (200), comprising a collimator with one or more confocal septa (29) attached to the input of the X-ray detector (30) with energy resolution at, followed by an amplification system (31) and MCA multichannel pulse processing (32) (FIG. 14).

13. The system for detecting, imaging and treating neoplasm according to claims 1 and 11, characterized in that the detector collimator (30) has one or more straight cylindrical (33) or conical (34) septa or conical honeycombed hexagonal septa (35) (FIG. 17), (FIG. 16) (FIG. 15).

14. The system for detecting, imaging and treating neoplasm according to claims 1 and 11, characterized in that the detector system comprises one or more solid state detectors, which are chosen from cadmium telluride (CdTe) (37) on support (36) or hyper pure Germanium (Ge) or NaI(Tl) sodium iodide scintillator. (FIG. 18).

15. The system for detecting, imaging and treating neoplasm according to claims 1, 11 and 13, characterized in that the detector system (30) is formed by at least one or more confocal detectors with an area greater than 0.25.sup.2 cm.sup.2) (38). (FIG. 18).

16. The system for detecting, imaging and treating neoplasm according to claims 1 and 15, characterized in that the detector system (30) is formed by at least two confocal detectors of area (greater than 0.25 cm.sup.2) (38), configured concentrically, until covering the entire visible area of radiation output of the object to be analyzed in an isotropic manner (FIG. 20).

17. The system for detecting, imaging and treating neoplasm according to claims 1 and 2, characterized in that the second convergent treatment device (300) has higher power than the convergent scanning X-ray device (100).

18. The system for detecting, imaging and treating neoplasm according to claims 1, 11 and 16, characterized in that it comprises second convergent treatment device (300) comprising direct electrical contacts and including cooling systems.

19. The system for detecting, imaging and treating neoplasm according to claims 1, 2 and 16, characterized in that it has a fast gate (310) comprising at least one metallic foil (41) attached to a bidirectional solenoid (42) which moves the foil to output the beam only when there is fluorescent signal recorded by the detection system, wherein the at least one metallic foil (41) is permanently interrupting the beam to completely attenuate the beam (<1%) when no fluorescent signal is recorded (FIGS. 21 and 22).

20. The system for detecting, imaging and treating neoplasm according to claim 1 or 2, characterized in that the static convergent scanning device (100) or fixed convergent treatment device (300) comprises a spherical circular gate with holes (45) comprising the same plurality of holes and with the same hole pattern as the spherical poly collimator (5), wherein the circular spherical gate with holes (45) rotates angularly and concentrically to the axis of the static convergent scanning device (100) or fixed convergent treatment device (300), to open the passage of the radiation beams, through a stepper motor (46), as it is permanently closed when the unit (200) does not detect fluorescent signal. (FIG. 23).

21. The system for detecting, imaging and treating neoplasm according to claim 1 or 2, characterized in that the support structure for Cartesian scanning (410), is formed by a flat base with grip holes (36) for support of detectors (30b) and the structure (51) comprising the support arch (8) rotating, which on its opposite sides has the supports for the X-ray device (12) to generate the convergent scanning beam 150 and the supports for the X-ray tube (47) to generate the beam of the dynamic convergent treatment X-ray device (47), wherein the collimator at the exit of the X-ray tube of the rotating device is mounted on a base that allows micro displacements in the X, Y plane.

22. The system for detecting, imaging and treating neoplasm according to claims 1, 2, and 20, characterized in that the Cartesian support structure (410) further houses convergent scanning device (100), and treatment device (300) in a combination of static and/or dynamic devices.

23. The system for detecting, imaging and treating neoplasm according to claim 1 or 2, characterized in that the 3D, Cartesian displacement structure (550) of the stretcher (62), comprises a set of rails (61) for linear displacement (X, Y) and another set of rails (61) for vertical displacement, through driving means (59, 60), to perform the Cartesian movement (X, Y, Z).

24. The system for detecting, imaging and treating neoplasm according to claim 1 or 2, characterized in that the 3D Cartesian polar displacement structure (570) of the stretcher (62), comprises a set of rails (61) for linear displacement (X) and another set of rails (61) for vertical displacement (Z), through driving means (59, 60), and means for angular displacements of the stretcher (62). (FIG. 30).

25. The system for detecting, imaging and treating neoplasm according to claim 28, characterized in that the supporting structure (400) further comprises sliding guides along the arc for moving the fixed convergent treatment device (200) the fixed convergent treatment device (300) and/or the static convergent scanning device (100) (FIG. 31).

26. The system for detecting, imaging and treating neoplasm according to claim 1, characterized in that it comprises an external shielded structure (67) which is mounted above the Cartesian support structure (410), wherein the external shielded structure (67) comprises shielded door (68).

27. The system for detecting, imaging and treating neoplasm according to claim 25, characterized in that the external shielded structure (67) comprises, a shielded observation window 71 and/or a set of cameras, some electronic control elements 70. (FIG. 35).

28. The system for detecting, imaging and treating neoplasm according to claim 1, characterized in that its cylindrical polar version comprises a double ring structural rail (66) with connecting plates (73), which supports a curved structure (65) with carriages (65b), which is joined by means of parallel guides with screws (64) to the supporting structure (400) by means of two parallel joints with thread (57) and motors (63), in turn the double ring structural rail (66) is joined to an external cylindrical structure with shielding (75) and central hollow, which in its external part houses external boxes for electronic control elements (70), on a support base (76); a stretcher (62) is located along the axis of the structure (75); this whole assembly (75, 62) allows movements of the supporting structure 400 in radial (ρ), angular (φ), and longitudinal (z) directions.

29. The system for detecting, imaging, and treating neoplasm according to claims 1, 2, 18, 22 and 23, characterized in that it comprises a general control unit interfacing with: a circuit of detectors that control the detectors (200), where the detectors are mounted on a base that allows angular and Cartesian micro displacements; a trigger control circuit, to control the at least one bidirectional solenoid (42) and let the treatment beam pass; convergent device control circuits, for controlling the convergent devices (100, 150); and 3D motion circuit, to control the motors (59, 60) wherein said circuits are controlled by a central processing and communication unit (FIG. 38).

30. The system for detecting, imaging and treating neoplasm according to claim 1 or 28, characterized in that it further comprises a computed tomograph (2000) comprising: a conventional X-ray tube (77), a system of collimators (78) and detectors (79) within the fluorescent confocal system (1000), wherein the fluorescent confocal (1000) and the computed tomograph (2000) are within the shielding (75) which are connected by means of a ring guide support (83) to the double ring structural rail (66), wherein the shielding (75) is solidly attached to a base (76) (FIG. 39).

31. The system for detecting, imaging and treating neoplasm according to claim 29, characterized in that the guide ring support (83) jointly joins the shielding (75) with the double ring structural rail (66).

32. The system for detecting, imaging and treating neoplasm according to claim 29, characterized in that the ring guide support (83) movably joins the shielding (75) with respect to the double ring structural rail (66), allowing the latter to rotate 360°, in a controlled manner, the fluorescent confocal (1000) and the computerized tomography (2000).

33. The system for detecting, imaging and treating neoplasm according to claim 1, characterized in that the X-ray devices (100) use energies in the orthovoltage range (100-750 keV).

34. The system for detecting, imaging and treating neoplasm according to claim 1, characterized in that the X-ray devices (100) use energies in the soft X-ray range, less than 100 keV, for superficial applications.

35. The system for detecting, imaging and treating neoplasm according to claim 1, characterized in that the convergent device (100, 150) has a dual function, first it operates in scan mode marking the area with a power of at most 50 W and second it operates in therapy mode by increasing the operating current with a power of at least 100 W.

36. The system for detecting, imaging and treating neoplasm according to claim 1, characterized in that the focal point of the convergent scanning device (100) is advanced in its scanning path, with respect to the path of the second treatment device (300), where the second treatment device (300) have the same scanning path as the convergent scanning device (100) allowing the theranostic mode. (Simultaneous Diagnosis and Treatment).

37. The system for detecting, imaging and treating neoplasm according claim 36, wherein the offset between the focal point of the convergent scanning device (100) is at least 1 millimeter with respect to the second treatment device (300), allowing the theranostic mode. (Simultaneous Diagnosis and Treatment).

38. A method of detecting, obtaining images and treating or eliminating of neoplasms, pathologies or other anomalies, which is excited through X-rays biomarked with metallic nanoparticles, characterized in that it includes the steps of: A. capturing anatomical images of the individual (“fantoma”, animal, person) to detect any anomaly, by means of a CT scanner (2000) which is inside an external support structure 600; B. if any anomaly is detected, then: mark an area of the individual and analyze the area with biomarker means through a confocal system (1000) by means of a three-dimensional scanning of the marked area, wherein the confocal system (1000) comprising an external shielded structure (67, 75), which inside comprises: an X-ray scanning convergent device (100), a detection system (200) for X photons with solidary collimators and confocal to the first device, a second convergent processing device (300) solidary to the same confocal structure (100 and 200) and a supporting structure (400) containing the X-ray scanning convergent device (100), the detection system (200) and the second convergent processing device (300), which project to a single focal point and which ensures that they are confocal; and C. if biomarker X-ray fluorescence signal is detected by detection system (200), then apply convergent treatment device (300), wherein convergent treatment device (300) applies radiation at the three-dimensional coordinates that the scanning X-ray convergent device (100) generated X-ray fluorescence detected by detection system (200).

39. The method for detecting, obtaining images and treating or eliminating of neoplasms according to claim 37, characterized in that it comprises repeating step C, until the sweep is completed over the entirety of the marked area.

40. The method for detecting, imaging and treating or eliminating neoplasms according to claim 37 or 38, wherein advancing the scanning path of the focal point of the convergent scanning device (100), relative to the path of the second treatment device (300), wherein the second treatment device (300) have the same scanning path as the convergent scanning device (100) enabling the theranostic mode. (Simultaneous Diagnosis and Treatment)

41. The method for detecting, imaging and treating or eliminating neoplasms according to claim 37 or 38 or 39, characterized in that the three-dimensional scan in the marked area comprises: a. performing helical paths (r, φ) or helix (r, φ) or concentric (r, φ) or zig-zag arcs (r, φ) or Cartesian (x, y) with the focal point of the devices (100 and 300) increasing or decreasing; b. longitudinally displacing the focal point of the devices (100 and 300), in the coordinate in (z or −z); and c. repeating steps a. and b. until the demarcated area is covered. (FIGS. 32 and 33 with 3D cylindrical radial scanning device)

42. The method of detecting, imaging and treating or eliminating neoplasms according to claims 37 to 40, wherein: i. defining the scan paths through a computer 800 in a marked area and coordinating the reading of the fluorescent signals coming from the detection system with the position of the scanning, wherein the marked area comprises the volume of the anomalies and the variability of the displacement of these anomalies (neoplastic cells), wherein a first reading is associated with a spatial point of the scan area; ii. defining the pixel of the 3D image that is built as the scanning path evolves; iii. constructing a 3D matrix of fluorescent intensities and a 3D image of the tumor inside the scanning zone; iv. maintaining the scanning in the scanning zone with the convergent scanning device (100), to ensure the correct location of each spatial point of the anomalies (neoplastic cells) through a second reading associated with a spatial point of the scanning zone; v. immediately applying the convergent beam of the convergent device 300 in the volume detected with the biomarker following the paths in the volumes with fluorescent signal and annihilate or treat the anomalies (neoplastic cells) at the same biomarker points and excited by the first beam, where the focal point of the second beam of the convergent device (300) is out of phase/offset with respect to the point already scanned by the convergent scanning device (100); vi. interrupting the convergent beam of the convergent device 300 when the detection system does not detect fluorescent signal through a fast triggering metal plate 41, to immediately apply the convergent beam of the convergent device (300) only when the detection system 200 detects fluorescent signal due to excitation of the biomarked cells, induced by the scanning convergent device (100); vii. repeating steps iv to vi, until covering the entire treatment scan volume of the marked area defined by the spatial position of the volume comprising the anomalies and the variability of the displacement of said anomalies (neoplastic cells).

Description

DESCRIPTION OF THE DRAWINGS

[0147] FIG. 1 basic device on support structure.

[0148] FIG. 2 large convergent beam cylindrical X-ray tube formed by a curved cylinder as the anode.

[0149] FIG. 3 shows elementary dynamic convergent device with support arm and rotation shaft/axis.

[0150] FIG. 4 shows a convergent beam device formed by a curved cylinder.

[0151] FIG. 5 shows a convergent beam device formed by a curved ring as the anode.

[0152] FIG. 6 shows convergent beam device formed by long curved cylinder as anode.

[0153] FIG. 7 shows dynamic convergent device with curved support arm, with shaft of rotation and fixed holes in different positions.

[0154] FIG. 8 shows a dynamic convergent device with a curved support arm C, shaft of rotation and slots that allow the angle of the convergent cone to be set.

[0155] FIG. 9 shows a dynamic convergent device with a curved supporting arm, with a shaft of rotation, with slots along it, with racks and motors.

[0156] FIG. 10 shows a straight arm dynamic convergent device with a rotation shaft, with a fixed radius and angle.

[0157] FIG. 11 shows dynamic convergent device with straight arm with rotation shaft, with holes fixed in different positions, same focal point.

[0158] FIG. 12 shows dynamic convergent device with straight arm with rotation shaft, with motors to vary the angle of the X-ray tube and counterweight.

[0159] FIG. 13 shows a dynamic convergent device with a straight arm with a rotation shaft, with a long slot with a rack and electric motors.

[0160] FIG. 14 shows a schematic of the confocal detection system.

[0161] FIG. 15 shows a large-area confocal collimator with straight confocal septa.

[0162] FIG. 16 shows a large-area confocal collimator with conical confocal septa.

[0163] FIG. 17 shows large-area confocal collimator hexagonal honeycomb confocal septa.

[0164] FIG. 18 shows a detection system formed by a set of solid state detectors of the CdTe type.

[0165] FIG. 19 shows detection system with two confocal detectors with larger detection area ˜100 cm.sup.2 each.

[0166] FIG. 20 shows a detection system with a greater number of confocal detectors with a larger area.

[0167] FIG. 21 shows a fast beam attenuator gate formed by a metal foil driven by a solenoid.

[0168] FIG. 22 shows a fast double gate for complete attenuation (<1%) of the static convergent beam formed by metal foils driven by a solenoid.

[0169] FIG. 23 shows a spherical circular gate for full attenuation (<1%) with holes following the same hole pattern as the collimator, with axis on the optical axis of the static convergent device.

[0170] FIG. 24 shows a fast gate for complete attenuation (<1%) of the dynamic convergent beam formed by a metal foil driven by a solenoid, mounted on the collimator output.

[0171] FIG. 25 shows the supporting structure for the Cartesian movement option, it is formed by an arch where the convergent sources are supported and the base for the support of the detectors.

[0172] FIG. 26 shows Cartesian support structure with two convergent dynamic scanning and processing devices.

[0173] FIG. 27 shows a supporting structure with cylindrical movement, formed by a C-shaped arch on which the three basic devices are supported.

[0174] FIG. 28 shows the supporting structure of cylindrical movement, formed by a longer C-shaped arch with an additional detector.

[0175] FIG. 29 shows the supporting structure of cylindrical movement, formed by a C-shaped arch with a combination of static dynamic convergent elements.

[0176] FIG. 30 shows the 3D Cartesian motion device, formed by the synchronized adaptation of two commercial 3D bridge-type printers in a mirror configuration that gives the system more robustness.

[0177] FIG. 31 shows a cylindrical 3D motion device, formed by the synchronized movement of the stretcher in the Z axis plus the radial and angular movement of the movement of the C-shaped supporting structure.

[0178] FIG. 32 shows cylindrical scanning/sweep scheme.

[0179] FIG. 33 shows zig-zag scanning/sweep scheme.

[0180] FIG. 34 shows an external Cartesian support structure that allows the installation of all the pieces and parts of this invention and the shielding.

[0181] FIG. 35 shows closed, complete Cartesian external support structure.

[0182] FIG. 36 shows a cylindrical external support structure that allows the installation of all the pieces and essential parts of this invention and the shielding.

[0183] FIG. 37 shows closed, complete Cartesian cylindrical external support structure.

[0184] FIG. 38 shows the overall schematic of the electronic circuit with electronic circuit box associated with the five electronic circuit units that make up the complete system.

[0185] FIG. 39 shows global structure with incorporated CT (Scanner or Computerized Tomography)

[0186] FIG. 40 shows: complete view device closed.

DETAILED DESCRIPTION OF THE INVENTION

[0187] According to what is shown in at least FIGS. 1, 2, 3, 16, 19, 21, 26, 31, 32, 38 and 39, the present invention discloses a system for detecting, obtaining images and treating or eliminating neoplasms, pathologies or other anomalies, which is excited through X-rays biomarked with metallic nanoparticles comprising:

[0188] An external shielded support structure 600 comprising: [0189] A. a confocal system (1000) comprising a shielded external structure (67, 75), which inside comprises: a scanning X-ray convergent device (100), a detection system (200) for X photons with collimators solidary and confocal to the first device, a second convergent processing device (300) solidary to the same confocal structure (100 and 200) and a supporting structure (400) containing the scanning X-ray convergent device (100), the detection system (200) and the second convergent processing device (300), which project to a single focal point and which ensures that they are confocal; [0190] B. a controlled 3D scanning structure (500) moving a stretcher and/or focal point where the ionizing radiation is concentrated; [0191] C. an electronic control system comprising: [0192] a programmable electronics (700) allowing the operation of the convergent beam device, the operation of the detectors (2) and the movements of the 3D scanning system; and [0193] D. a computerized tomography CT (2000) comprising collimators, X-ray tube and detectors is incorporated in the same structure (600).

[0194] Which also includes a large confocal system (1000) of at least 100 cm.sup.3 or more disposed of three essential elements (100, 200, 300) (FIG. 1).

[0195] In a preferred configuration, it has a static cylindrical convergent ionizing radiation scanning device (100) in vacuum, consisting of an electron gun (1), a beam braker (2), a white metallic cylinder 3 of high Z (>50) covered by a cylinder of a conductive material (Al or Cu) (4), a spherical cap (5) as collimator with separate collimation holes 6 pointing to a focal point and confocal laser guides (7) (FIG. 2).

[0196] In another preferred configuration it has a dynamic convergent ionizing radiation scanning device (150), formed by a rotating arc support (8) with shaft/axis (9), bearings (10), bar (11) with confocal laser guides (7), X-ray tube (12), collimator (13) and counterweight (14) at one end, rotating by means of a reduction and connection system (53) and an electric motor (52), collimator (13) and counterweight (14) at one end, rotating by means of a reduction and connection system (53) and an electric motor (52), the X-ray output is collimated by means of a collimator 13 that points to the focal point of the system 150 (FIG. 3).

[0197] Where, the device is formed by a curved anode cylinder (110) (FIG. 4) or a curved anode ring (120) (FIG. 5) or by a long curved anode cylinder (130) (FIG. 6).

[0198] In another preferred configuration, it has a support structure (8, 24) with position adjustment means (19, 20, 22, 27) that allow the X-ray tube (12) to be fixed with the direction of its collimated output pointing towards the focal point and its projection is perpendicular to the tangent line of the arc that intersects it, the convergent cone angle is generated at preset positions without changing the position of the focal point (FIGS. 7 a 13).

[0199] In another preferred configuration, the support structure is selected from a supporting arch (8) or a straight arm (24) centered at the focal point.

[0200] In another preferred configuration, the position adjustment means are selected from among position holes (19), a long curved slot (20), a curved toothed slot (22) or a straight toothed slot (27) that allows varying the convergent cone angle.

[0201] The system also comprises an electric motor (23) that allows the angle of the convergent cone to be varied continuously, and two other motors (23) moving the X-ray tube 12 together with the counterweight 14 in opposite directions along the C-arc respectively (FIG. 9).

[0202] Wherein, the support structure comprises an angular fixing (25) and an angular electric motor (26) to vary the angle of the convergent cone (FIG. 10, 12).

[0203] In another preferred configuration, the support structure is attached to the system by means of the shaft (9), straight arm 24 and has straight toothed slot (27) along the arm with shaft 9 and an electric motor that allows to vary the angle of the convergent cone (28) in a continuous way, and two other motors (23) move the X-ray tube together and the compensator in opposite directions along the arm respectively (FIG. 13).

[0204] Wherein, a confocal detection system (200), formed by a collimator with one or more confocal septa (29) attached to the input of the X-ray detector (30) with energy resolution in, followed by an amplification system (31) and MCA multichannel pulse processing (32) (FIG. 14).

[0205] In another preferred configuration, the detector collimator (30) has one or more straight cylindrical (33) or conical (34) septa or hexagonal conical honeycomb-shaped septa (35) (FIG. 17), (FIG. 16) (FIG. 15).

[0206] Wherein, the detector system consists of one or more solid state detectors, which are chosen from cadmium telluride (CdTe) (37) on support (36) or hyper pure Germanium (Ge) or NaI(Tl) sodium iodide scintillator. (FIG. 18).

[0207] In another preferred configuration, the detector system (30) is made up of at least one or more confocal detectors with an area greater than 0.25.sup.2 cm.sup.2) (38). (FIG. 18).

[0208] The detector system (30) is made up of at least two area confocal detectors (greater than 0.25 cm.sup.2) (38), configured concentrically, until covering the entire visible radiation output area of the object to be analyzed isotropically (FIG. 20).

[0209] The second convergent treatment device (300) has higher power than the convergent X-ray scanning device (100), wherein the second convergent treatment device (300) comprises direct electrical contacts and included cooling systems.

[0210] In another preferred configuration, a fast gate (310) comprising at least one metal foil (41) attached to a bidirectional solenoid (42) which moves the foil to output the beam only when there is a fluorescent signal recorded by the detection system, wherein at least one metal foil (41) is permanently interrupting the beam, to completely attenuate the beam (<1%), when no fluorescent signal is recorded (FIGS. 21 and 22).

[0211] The static convergent scanning convergent device (100) or fixed convergent treatment device (300) comprises a circular spherical hole gate (45) comprising the same plurality of holes and with the same hole pattern as the spherical poly collimator (5), wherein the circular spherical gate with holes (45) rotates angularly and concentrically to the axis of the static scanning convergent device (100) or fixed treatment convergent device (300), to open the passage of the radiation beams, through a stepper motor (46), as it is permanently closed when the unit (200) does not detect fluorescent signal. (FIG. 23).

[0212] Wherein, the support structure for Cartesian scanning (410), is formed by a flat base with grip holes (36) for support of detectors (30b) and the structure (51) comprising the rotating arc support (8), which on its opposite sides has the supports for the X-ray device (12) to generate the convergent scanning beam 150 and the supports for the X-ray tube (47) to generate the beam of the dynamic convergent treatment X-ray device (47), wherein the collimator at the exit of the X-ray tube of the rotating device is mounted on a base that allows micro displacements in the X, Y plane.

[0213] In another preferred configuration, the Cartesian support structure (410) further houses Convergent Scanning Device (100) and Convergent Treatment Device (300) in a combination of static and/or dynamic devices.

[0214] Wherein, the 3D Cartesian displacement structure (550) of the stretcher (62), comprises a set of rails (61) for linear displacement (X, Y) and another set of rails (61) for vertical displacement, through driving means (59, 60), to perform the Cartesian movement (X, Y, Z)

[0215] Wherein, the 3D Cartesian polar Cartesian displacement structure (570) of the stretcher (62), comprises a set of rails (61) for linear displacement (X) and another set of rails (61) for vertical displacement (Z), through driving means (59, 60), and a means for angular displacements of the stretcher (62). (FIG. 30).

[0216] Wherein, the supporting structure (400) further comprises sliding guides along the arc (not shown in the figures) for moving the fixed convergent treatment device (200) the fixed convergent treatment device (300) and/or the static convergent scanning device (100) (FIG. 31).

[0217] In another preferred configuration, a shielded external structure (67) that is mounted above the Cartesian support structure (410), wherein the shielded external structure (67) comprises shielded door (68).

[0218] Wherein, the external shielded structure (67) comprises, a shielded observation window 71 and/or a set of cameras, some electronic control elements 70. (FIG. 35).

[0219] In another preferred configuration, its cylindrical polar version comprises a double ring structural rail (66) with connecting plates (73), which supports a curved structure (65) with carriages (65b), which is joined by means of parallel guides with screws (64) to the supporting structure (400) by means of two parallel joints with wire (57) and motors (63), in turn, the double ring structural rail (66) is joined to an external cylindrical structure with shielding (75) and central hollow, which in its external part houses external boxes for electronic control elements (70), on a support base (76); a stretcher (62) is located along the axis of the structure (75); this whole assembly (75, 62) allows movements of the supporting structure 400 in radial (p) angular ((p) and longitudinal (z) direction.

[0220] The detection system, comprising a general control unit which is connected to: a detector circuit controlling the detectors (200), wherein the detectors are mounted on a base allowing angular and Cartesian micro displacements; a trigger control circuit, for controlling the at least one bidirectional solenoid (42) and letting the processing beam through; convergent device control circuits, for controlling the convergent devices (100, 150); and 3D motion circuitry, for controlling the motors (59, 60), wherein said circuits are controlled by a central processing and communication unit (FIG. 38).

[0221] In another preferred configuration, it further comprises a computed tomograph (2000) comprising: a conventional X-ray tube (77), a system of collimators (78) and detectors (79) within the fluorescent confocal system (1000), wherein the fluorescent confocal (1000) and the computed tomograph (2000) are within the shielding (75) which are connected by means of a ring guide support (83) to the double ring structural rail (66), wherein the shielding (75) is solidly attached to a base (76) (FIG. 39).

[0222] In another preferred configuration, the ring guide support (83) joins the shield (75) solidly with the double rail structural ring (66).

[0223] In another preferred configuration, the ring guide support (83) movably joins the shielding (75) with respect to the double ring structural rail (66), allowing the latter to rotate by 360°, in a controlled manner, the fluorescent confocal (1000) and the computed tomograph (2000).

[0224] In another preferred configuration, the X-ray devices (100) use energies in the orthovoltage range (100-750 keV).

[0225] Wherein, X-ray devices (100) use energies in the soft X-ray range, less than 100 keV, for surface applications.

[0226] In another preferred configuration, the convergent device (100, 150) has a dual function, first it operates in scan mode by marking the zone with a power of at least 50 W and second it operates in therapy mode by increasing the operating current with a power of at least 100 W.

[0227] Wherein, the focal point of the convergent scanning device (100) is advanced in its scanning path, with respect to the path of the second treatment device (300), wherein the second treatment device (300) have the same scanning path as the convergent scanning device (100) enabling the theranostic mode. (Simultaneous Diagnosis and Treatment).

[0228] In another preferred configuration, the offset between the focal point of the convergent scanning device (100) is at least 1 millimeter with respect to the second treatment device (300), enabling the theranostic mode. (Simultaneous Diagnosis and Treatment).

[0229] A method for detecting, imaging, and treating or eliminating neoplasms, pathologies, or other abnormalities, which is excited through X-rays biomarked with metallic nanoparticles comprising the steps of: [0230] A. capturing anatomical images of the individual (“fantoma”, animal, person) to detect any anomaly, by means of a CT scanner (2000) which is inside an external support structure 600; [0231] B. if any anomaly is detected, then: mark an area of the individual and analyze the area with biomarker means through a confocal system (1000) by means of a three-dimensional scanning of the marked area, wherein the confocal system (1000) comprising an external shielded structure (67, 75), which inside comprises: an X-ray scanning convergent device (100), a detection system (200) for X photons with solidary collimators and confocal to the first device, a second convergent processing device (300) solidary to the same confocal structure (100 and 200) and a supporting structure (400) containing the X-ray scanning convergent device (100), the detection system (200) and the second convergent processing device (300), which project to a single focal point and which ensures that they are confocal; and [0232] C. if biomarker X-ray fluorescence signal is detected by detection system (200), then apply convergent treatment device (300), wherein convergent treatment device (300) applies radiation at the three-dimensional coordinates that the scanning X-ray convergent device (100) generated X-ray fluorescence detected by detection system (200).

[0233] In addition, it includes repeating step C, until completing the scan in the entire marked area.

[0234] It further comprises advancing the scanning path of the focal point of the convergent scanning device (100), with respect to the path of the second treatment device (300), wherein the second treatment device (300) have the same scanning path as the convergent scanning device (100) enabling the theranostic mode. (Simultaneous Diagnosis and Treatment)

[0235] Wherein, the three-dimensional sweep in the marked area comprises: [0236] a. performing helical paths (r, φ) or helix (r, φ) or concentric (r, φ) or zig-zag arcs (r, φ) or Cartesian (x, y) with the focal point of the devices (100 and 300) increasing or decreasing; [0237] b. longitudinally displacing the focal point of the devices (100 and 300), in the coordinate in (z or −z); and [0238] c. repeating steps a. and b. until the demarcated area is covered. [0239] (FIGS. 32 and 33 with 3D cylindrical radial scanning device)

[0240] The method of detecting, imaging, and treating or eliminating neoplasms further comprises: [0241] i. defining the scan paths through a computer 800 in a marked area and coordinating the reading of the fluorescent signals coming from the detection system with the position of the scanning, wherein the marked area comprises the volume of the anomalies and the variability of the displacement of these anomalies (neoplastic cells), wherein a first reading is associated with a spatial point of the scan area; [0242] ii. defining the pixel of the 3D image that is built as the scanning path evolves; [0243] iii. constructing a 3D matrix of fluorescent intensities and a 3D image of the tumor inside the scanning zone; [0244] iv. maintaining the scanning in the scanning zone with the convergent scanning device (100), to ensure the correct location of each spatial point of the anomalies (neoplastic cells) through a second reading associated with a spatial point of the scanning zone; [0245] v. immediately applying the convergent beam of the convergent device 300 in the volume detected with the biomarker following the paths in the volumes with fluorescent signal and annihilate or treat the anomalies (neoplastic cells) at the same biomarker points and excited by the first beam, where the focal point of the second beam of the convergent device (300) is out of phase/offset with respect to the point already scanned by the convergent scanning device (100); [0246] vi. interrupting the convergent beam of the convergent device 300 when the detection system does not detect fluorescent signal through a fast triggering metal plate 41, to immediately apply the convergent beam of the convergent device (300) only when the detection system 200 detects fluorescent signal due to excitation of the biomarked cells, induced by the scanning convergent device (100); [0247] vii. repeating steps iv to vi, until covering the entire treatment scan volume of the marked area defined by the spatial position of the volume comprising the anomalies and the variability of the displacement of said anomalies (neoplastic cells).

COMPONENT LIST

[0248] 1. Electron gun. [0249] 2. Beam brake. [0250] 3. Conductive external cylinder. [0251] 4. White metallic inner cylinder. [0252] 5. Spherical poly-collimator. [0253] 6. Septa holes. [0254] 7. Confocal laser guides. [0255] 8. Supporting arch. [0256] 9. Shaft/Axis. [0257] 10. Bearings [0258] 11. Laser guide bar. [0259] 12. X-ray tube. [0260] 13. X-ray tube collimator [0261] 14. Counterweight [0262] 15. Clamp support [0263] 16. White curved cylinder [0264] 17. White conical ring [0265] 18. Long White Curved Conical Cylinder [0266] 19. Position holes [0267] 20. Long curved slot [0268] 21. Fixing bolt [0269] 22. Curved toothed slot [0270] 23. Electric motor tube position in the arc [0271] 24. Supportive straight arm [0272] 25. Angular fixing. [0273] 26. Angular electric motor. [0274] 27. Toothed straight slot. [0275] 28. Counterweight displacement electric motor/treatment tube. [0276] 29. Septa collimator detector. [0277] 30. X-ray detector. [0278] 30b. Detector support. [0279] 31. Pulse amplifier. [0280] 32. MCA pulse processor. [0281] 33. Confocal detector collimator with cylindrical septa [0282] 34. Confocal detector collimator with conical septa. [0283] 35. Collimator with honeycomb detector septa. [0284] 36. Flat base with grip holes [0285] 37. Confocal cadmium telluride detector with collimators [0286] 38. Large area detector (from 50 cm.sup.2 or more). [0287] 39. Support base for multiple detectors [0288] 40. Convergent static treatment device [0289] 41. Metallic foil/sheet [0290] 42. Bidirectional solenoid. [0291] 43. Solenoid shaft [0292] 44. Shaft gate fixings [0293] 45. Spherical circular gate with holes. [0294] 46. Stepper motor opening/closing [0295] 47. Dynamic convergent treatment X-ray device [0296] 48. Collimator solenoid fixing [0297] 49. Supportive legs. [0298] 50. Structural flat base. [0299] 51. Arch support structure. [0300] 52. Driving electric motor [0301] 53. Reducer [0302] 54. Treatment X-ray tube support [0303] 55. Arch of essential supporting structure. [0304] 56. Fixing elements devices [0305] 57. Parallel joint with thread. [0306] 58. Base structure of commercial 3D printer [0307] 59. Encoder [0308] 60. Stepper motor 3D Cartesian system. [0309] 61. Rails [0310] 62. Stretcher. [0311] 63. Parallel motors for radial movement [0312] 64. Parallel guides with screw. [0313] 65. Curved structure [0314] 65B. Double ring sliding carriages [0315] 66. Double ring structural rail [0316] 67. Shielded external structure for ionizing radiation. [0317] 68. Reinforced door. [0318] 69. Braked wheels. [0319] 70. External boxes electronic control elements. [0320] 71. Shielded observation window. [0321] 72. Reducer motor box. [0322] 73. Union plate. [0323] 74. Fixings to plate and double ring to external structure. [0324] 75. Shielded cylindrical external structure. [0325] 76. Support base. [0326] 77. Conventional X-ray tube of the CAT (Computed Tomograph/Scanner) [0327] 78. TAC collimator system [0328] 79. X-ray detectors [0329] 80. Electronics associated with the TAC [0330] 81. Carriages for TAC movement [0331] 82. C structure of 180° TAC [0332] 83. Ring guide support [0333] 84. Toothed circular rail [0334] 85. Electric motor [0335] 100. Convergent scanning device [0336] 110. Static curved convergent device [0337] 120. Static ring convergent device [0338] 130. Static long curved convergent device [0339] 150. Dynamic convergent scanning device [0340] 200. Detection system [0341] 300. Fixed convergent treatment device [0342] 310. Fast gate [0343] 400. Supporting structure [0344] 410. Cartesian support structure [0345] 500. 3D motion structure [0346] 550. Cartesian 3D motion structure [0347] 570. Cylindrical 3D Motion Structure [0348] 600. Overall assembly [0349] 650. General assembly cylindrical version [0350] 700. Programmable Electronic System and Control Method [0351] 800. Computer [0352] 1000. Fluorescent confocal system [0353] 2000. Computerized tomography CT [0354] 3000. Device System for detecting, obtaining images and treating or removing neoplasms